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Genetic counselling in hereditary osteo-onychodysplasia (HOOD, nail-patella syndrome) with nephropathy. | Hereditary osteo-onychodysplasia (HOOD, nail-patella syndrome) is an autosomal dominant condition characterised by nail dysplasia, patellar hypoplasia or aplasia, and nephropathy. The risk for HOOD patients to have a child with HOOD who will develop renal failure cannot easily be deduced from published pedigrees. We ha... | ['Adult', 'Female', 'Genetic Counseling', 'Humans', 'Kidney Diseases', 'Male', 'Nail-Patella Syndrome', 'Pedigree'] | 3,225,824 | [['M01.060.116'], ['H01.158.273.343.385.500.384', 'N02.421.308.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419', 'C13.351.968.419'], ['C05.550.629', 'C16.131.077.606', 'C16.320.600', 'C17.800.529.400'], ['E05.393.673']] | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Waterborne cadmium impacts immunocytotoxic and cytogenotoxic endpoints in green-lipped mussel, Perna canaliculus. | Mussels are sentinel species that can be used to monitor coastal metal pollution through the application of biomarkers. Among the several important metal toxicants in coastal settings, cadmium (Cd) is of particular concern, being a non-essential metal that is known to cause harmful impacts in aquatic organisms at low c... | ['Animals', 'Cadmium', 'DNA Damage', 'Gills', 'Hemocytes', 'Micronucleus Tests', 'Perna', 'Water Pollutants, Chemical'] | 24,077,184 | [['B01.050'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['G05.200'], ['A13.421'], ['A11.118.480', 'A15.145.229.480'], ['E05.393.560.598'], ['B01.050.500.644.080.537.600'], ['D27.888.284.903.655']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spirometry training courses: Content, delivery and assessment - a position statement from the Australian and New Zealand Society of Respiratory Science. | Spirometry training courses are provided by health services and training organizations to enable widespread use of spirometry testing for patient care or for monitoring health. The primary outcome of spirometry training courses should be to enable participants to perform spirometry to international best practice, inclu... | ['Australia', 'Certification', 'Clinical Competence', 'Education, Medical, Continuing', 'Humans', 'New Zealand', 'Practice Guidelines as Topic', 'Primary Health Care', 'Pulmonary Medicine', 'Quality Assurance, Health Care', 'Reference Values', 'Respiratory Tract Diseases', 'Societies, Medical', 'Spirometry'] | 28,681,980 | [['Z01.639.100', 'Z01.678.100.373'], ['N03.706.110.120', 'N05.700.200.190'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.358.212.350', 'I02.358.399.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.639.760.747', 'Z01.678.100.747'], ['N04.761.700.350.650', 'N05.700.350.650'], ['N04.590.233.727']... | ['Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Complex glycerol kinase deficiency leads to psychomotor and body-growth failure. | Complex glycerol kinase deficiency usually presents with Duchenne muscular dystrophy, glycerol kinase deficiency and adrenal hypoplasia congenital. We describe a follow-up patient with complex glycerol kinase deficiency who had appropriate intrauterine development, but who at 1 month of age manifested severe growth del... | ['Biopsy', 'Child', 'Child, Preschool', 'Fetal Diseases', 'Glycerol Kinase', 'Growth Disorders', 'Humans', 'Male', 'Muscle, Skeletal', 'Muscular Dystrophy, Duchenne', 'Psychomotor Disorders', 'Surveys and Questionnaires'] | 15,009,558 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['M01.060.406'], ['M01.060.406.448'], ['C13.703.277', 'C16.300'], ['D08.811.913.696.620.275'], ['C23.550.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.567',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Polymorphisms in the melatonin receptor gene promoter and their associations with fertility characteristics in buffalo herd in Eastern Amazon. | Buffalo production is spreading globally because of its economic advantage. Then, it has become necessary to improve the reproductive and productive efficiency of these animals, as well as to look for genetic factors that increase this efficiency. The objectives of this study were to characterize the promoter region of... | ['Animals', 'Buffaloes', 'Female', 'Fertility', 'Gene Frequency', 'Polymorphism, Single Nucleotide', 'Promoter Regions, Genetic', 'Receptors, Melatonin'] | 28,549,203 | [['B01.050'], ['B01.050.150.900.649.313.500.380.135'], ['G08.686.210'], ['G05.330'], ['G05.365.795.598'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D12.776.543.750.695.440', 'D12.776.826.590']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The enterohepatic recycling of bile choline in sheep. | 1. Measurement of unesterified choline in blood samples taken from five conscious multi-cannulated sheep indicated a significant production of unesterified choline by the alimentary tract, as judged by the portal venous minus arterial difference and significant uptake by the liver, as judged from the portal venous minu... | ['Animals', 'Bile', 'Choline', 'Enterohepatic Circulation', 'Female', 'Infusions, Intravenous', 'Intubation, Gastrointestinal', 'Male', 'Sheep'] | 2,890,469 | [['B01.050'], ['A12.200.087'], ['D02.033.100.291.211', 'D02.092.063.291.211', 'D02.092.877.883.333', 'D02.675.276.232'], ['G03.312'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['E02.585.412', 'E05.497.412'], ['B01.050.150.900.649.313.500.380.791']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased susceptibility to complement attack due to down-regulation of decay-accelerating factor/CD55 in dysferlin-deficient muscular dystrophy. | Dysferlin is expressed in skeletal and cardiac muscles. However, dysferlin deficiency results in skeletal muscle weakness, but spares the heart. We compared intraindividual mRNA expression profiles of cardiac and skeletal muscle in dysferlin-deficient SJL/J mice and found down-regulation of the complement inhibitor, de... | ['Adult', 'Animals', 'CD55 Antigens', 'Complement System Proteins', 'Down-Regulation', 'Dysferlin', 'Female', 'Humans', 'Male', 'Membrane Proteins', 'Mice', 'Mice, Inbred C57BL', 'Middle Aged', 'Muscle Fibers, Skeletal', 'Muscle, Skeletal', 'Muscular Dystrophies', 'Myostatin', 'Smad3 Protein', 'Transforming Growth Fact... | 16,237,120 | [['M01.060.116'], ['B01.050'], ['D12.776.395.550.448.130', 'D12.776.543.484.500.130', 'D12.776.543.550.418.130'], ['D12.776.124.486.274'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D12.776.210.500.248', 'D12.776.543.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543'], ['B01.050.150.900.64... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Santeria and Palo Mayombe: skulls, mercury, and artifacts. | Santeria and Palo Mayombe are syncretic religions created in the New World based upon African religious beliefs combined with Christianity. The main worship of Palo Mayombe involves religious receptacles that may contain earth, sticks, varied artifacts, and animal and human remains. Due to the use of human and nonhuman... | ['Animals', 'Caribbean Region', 'Ceremonial Behavior', 'Forensic Anthropology', 'Humans', 'Mercury', 'New York City', 'Religion', 'Skull'] | 19,804,524 | [['B01.050'], ['Z01.107.084'], ['F01.145.813.097', 'I01.076.201.450.170'], ['I01.076.368.400', 'I01.198.780.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['Z01.107.567.875.350.530.530', 'Z01.107.567.875.500.530.530', 'Z01.433.741'], ['K01.844'], ['A02... | ['Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Humanities [K]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Erectile dysfunction: a significant health need in patients with coronary heart disease. | BACKGROUND AND AIMS: Erectile dysfunction (ED) is a common condition, which negatively affects quality of life, and shares similar risk factors with Coronary Heart Disease (CHD). Studies from the pre - sildenafil era confirm a higher risk of ED in patients with cardiovascular disease. The high profile and success of si... | ['Coronary Disease', 'Erectile Dysfunction', 'Humans', 'Male', 'Middle Aged', 'Referral and Consultation', 'Surveys and Questionnaires'] | 15,462,224 | [['C14.280.647.250', 'C14.907.585.250'], ['C12.294.644.486', 'F03.835.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N04.452.758.849'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1. | Cholesteryl ester transfer protein (CETP) is expressed in human adipocytes, where it acts to promote selective uptake of HDL-CE (Benoist, F., M. McDonnell, P. Lau, R. Milne, and R. McPherson. 1997. J. Biol. Chem. 272: 23572;-23577). In contrast to other major sterol-responsive genes such as 3-hydroxy-3-methylglutaryl c... | ['Animals', 'CCAAT-Enhancer-Binding Proteins', 'Carrier Proteins', 'Cholesterol', 'Cholesterol Ester Transfer Proteins', 'Cricetinae', 'DNA', 'DNA-Binding Proteins', 'Erythroid-Specific DNA-Binding Factors', 'Glycoproteins', 'Humans', 'Hydroxycholesterols', 'Lipids', 'Nuclear Proteins', 'Promoter Regions, Genetic', 'RN... | 10,393,213 | [['B01.050'], ['D12.776.260.108.124', 'D12.776.660.167', 'D12.776.930.127.124'], ['D12.776.157'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D09.400.430.750', 'D12.776.124.197', 'D12.776.157.165', 'D12.776.395.199'], ['B01.050.150.900.649.313.992.635.075.250'], ['D13.444.308'], ['D12.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A Sustainable Model For Delivering High-Quality, Efficient Cataract Surgery In Southern India. | Cataracts are a leading cause of reversible blindness in India, where millions of people can be effectively treated for this condition with surgery. The Aravind Eye Care System in southern India developed an efficient system for delivering high-quality and low-cost cataract surgery. We provide a detailed accounting of ... | ['Blindness', 'Cataract Extraction', 'Cost-Benefit Analysis', 'Female', 'Health Expenditures', 'Humans', 'India', 'Lens Implantation, Intraocular', 'Male', 'Middle Aged', 'Quality-Adjusted Life Years'] | 27,702,949 | [['C10.597.751.941.162', 'C11.966.075', 'C23.888.592.763.941.162'], ['E04.540.825.249'], ['N03.219.151.125'], ['N03.219.151.450', 'N05.300.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['E04.540.825.600'], ['M01.060.116.630'], ['E05.318.740.100.500.700', 'N01.224.935.530.700']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The nature of the neutral Na+-Cl(-)-coupled entry at the apical membrane of rabbit gallbladder epithelium: II. Na+-Cl- symport is independent of K+. | In the epithelium of rabbit gallbladder, in the nominal absence of bicarbonate, intracellular Cl- activity is about 25 mM, about 4 times higher than intracellular Cl- activity at the electrochemical equilibrium. It is essentially not affected by 10(-4) M acetazolamide and 10(-4) M 4-acetamido-4'-isothiocyanostilbene-2,... | ['Animals', 'Bumetanide', 'Carrier Proteins', 'Cell Membrane', 'Chlorides', 'Epithelium', 'Gallbladder', 'In Vitro Techniques', 'Kinetics', 'Potassium', 'Rabbits', 'Sodium', 'Sodium Chloride Symporters', 'Symporters'] | 3,585,978 | [['B01.050'], ['D02.065.884.150', 'D02.241.223.100.050.300.200', 'D02.455.426.559.389.127.020.452.500', 'D02.886.590.700.150'], ['D12.776.157'], ['A11.284.149'], ['D01.210.450.150', 'D01.248.497.158.215'], ['A10.272'], ['A03.159.439'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['D01.268.549.550', 'D01.268.557.575', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sex differences in spatial and non-spatial Y-maze performance after chronic stress. | Chronic restraint is known to alter hippocampal CA3 dendritic morphology and spatial memory in male rats. The present study examined whether female rats, which exhibit different anatomical adaptations to chronic stress than those of males, would also show spatial memory impairments. Male and female Sprague-Dawley rats ... | ['Animals', 'Behavior, Animal', 'Chronic Disease', 'Female', 'Male', 'Maze Learning', 'Memory', 'Rats', 'Rats, Sprague-Dawley', 'Sex Factors', 'Spatial Behavior', 'Stress, Physiological', 'Time Factors'] | 12,482,677 | [['B01.050'], ['F01.145.113'], ['C23.550.291.500'], ['F02.463.425.874.500'], ['F02.463.425.540'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['N05.715.350.675', 'N06.850.490.875'], ['F01.145.875'], ['G07.775'], ['G01.910.857']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Quetiapine attenuates cognitive impairment and decreases seizure susceptibility possibly through promoting myelin development in a rat model of malformations of cortical development. | Developmental delay, cognitive impairment, and refractory epilepsy are the most frequent consequences found in patients suffering from malformations of cortical development (MCD). However, therapeutic options for these psychiatric and neurological comorbidities are currently limited. The development of white matter und... | ['Animals', 'Animals, Newborn', 'Anticonvulsants', 'Cerebral Cortex', 'Cognition Disorders', 'Corpus Callosum', 'Disease Models, Animal', 'Malformations of Cortical Development', 'Maze Learning', 'Myelin Sheath', 'Nootropic Agents', 'Pentylenetetrazole', 'Quetiapine Fumarate', 'Rats, Sprague-Dawley', 'Recognition, Psyc... | 26,188,240 | [['B01.050'], ['B01.050.050.282'], ['D27.505.954.427.080'], ['A08.186.211.200.885.287.500'], ['F03.615.250'], ['A08.186.211.200.885.800.750'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C10.500.507', 'C16.131.666.507'], ['F02.463.425.874.500'], ['A08.637.600.500', 'A08.637.800.500', 'A08.675.542.512.560', 'A08.80... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Childhood and adolescent psychopathology and subsequent tobacco smoking in young adults: findings from an Australian birth cohort. | AIMS: To examine whether child and adolescent psychopathology predicts subsequent tobacco use at 14 and 21 years of age.DESIGN: Prospective birth cohort study.SETTING: Data are taken from the Mater Misericordiae Hospital and University of Queensland Study of Pregnancy and its outcomes (MUSP), a prospective longitudinal... | ['Adolescent', 'Attention Deficit Disorder with Hyperactivity', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Prospective Studies', 'Smoking', 'Tobacco Use Disorder', 'Young Adult'] | 22,340,634 | [['M01.060.057'], ['F03.625.094.150'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['F01.145.805'], ['C25.775.912', 'F03.900.912'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Thrombosis in systemic lupus erythematosus: a French collaborative study. | A retrospective study was undertaken of 120 children with systemic lupus erythematosus (SLE) seen in Paris and its immediate suburbs who fulfilled at least four of the American College of Rheumatology diagnostic criteria for SLE, and in whom the disease was diagnosed before the age of 16 and between January 1975 and De... | ['Adolescent', 'Blood Coagulation Factors', 'Cerebral Arteries', 'Child', 'Female', 'Humans', 'Lupus Coagulation Inhibitor', 'Lupus Erythematosus, Systemic', 'Male', 'Pulmonary Embolism', 'Retrospective Studies', 'Thrombophlebitis', 'Thrombosis'] | 1,905,123 | [['M01.060.057'], ['D12.776.124.125', 'D23.119'], ['A07.015.114.228'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.323.210.600', 'D12.776.124.790.651.114.323.210.600', 'D12.776.377.715.548.114.323.210.600', 'D23.113.475'], ['C17.300.480', 'C20.111.590'], ['C08.381.746', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Diagnostic yield of continuous video electroencephalography for paroxysmal vital sign changes in pediatric patients. | OBJECTIVE: We aimed to determine the diagnostic yield of continuous monitoring with video electroencephalography (cVEEG) for pediatric inpatients with paroxysmal vital sign changes (PVSCs), and to identify risk factors for the PVSCs being seizures, based on clinical information available before cVEEG initiation. We hyp... | ['Adolescent', 'Apnea', 'Bradycardia', 'Child', 'Child, Preschool', 'Cohort Studies', 'Electroencephalography', 'Female', 'Humans', 'Hypertension', 'Hypotension', 'Infant', 'Infant, Newborn', 'Male', 'Monitoring, Physiologic', 'Retrospective Studies', 'Seizures', 'Tachycardia', 'Video Recording', 'Vital Signs'] | 26,660,005 | [['M01.060.057'], ['C08.618.085', 'C23.888.852.130'], ['C14.280.067.319', 'C23.550.073.300'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['C... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[The effect of urokinase on hepatic fibrogenesis in rats]. | OBJECTIVE: To investigate the effect of urokinase on hepatic fibrogenesis in rats.METHODS: Hepatic fibrosis was induced in rats by complex pathogenic factors including subcutaneous injections of carbon tetrachloride, alcohol and cholesterol feeding. Animals were randomly divided into 3 groups: normal control group, hep... | ['Actins', 'Animals', 'Disease Models, Animal', 'Hydroxyproline', 'Liver', 'Liver Cirrhosis, Experimental', 'Liver Function Tests', 'Male', 'Plasminogen Activator Inhibitor 1', 'RNA, Messenger', 'Random Allocation', 'Rats', 'Rats, Wistar', 'Tissue Inhibitor of Metalloproteinase-1', 'Transforming Growth Factor beta1', '... | 20,038,332 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.125.072.401.623.478'], ['A03.620'], ['C06.552.630.467', 'C23.550.355.412.467', 'E05.598.500.468'], ['E01.370.372.460'], ['D12.644.861.695.500', 'D12.776.124.125.640', 'D12.776.872.69... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Role of Swi6/HP1 self-association-mediated recruitment of Clr4/Suv39 in establishment and maintenance of heterochromatin in fission yeast. | Swi6/HP1, an evolutionarily conserved protein, is critical for heterochromatin assembly in fission yeast and higher eukaryotes. In fission yeast, histone deacetylation by histone deacetylases is thought to be followed by H3-Lys-9 methylation by the histone methyltransferase Clr4/Suv39H1. H3-Lys-9-Me2 interacts with the... | ['Acetylation', 'Cell Cycle Proteins', 'Chromosomal Proteins, Non-Histone', 'Heterochromatin', 'Histone Methyltransferases', 'Histone-Lysine N-Methyltransferase', 'Histones', 'Methylation', 'Methyltransferases', 'Mutation', 'Protein Binding', 'Schizosaccharomyces', 'Schizosaccharomyces pombe Proteins'] | 21,224,386 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['D12.776.167'], ['D12.776.660.235', 'D12.776.664.235'], ['A11.284.430.106.279.345.190.160.180.383', 'D12.776.664.224.466', 'G05.360.160.180.383'], ['D08.811.913.555.500.800.200'], ['D08.811.913.555.500.800.200.500'], ['D12.776.157.687.485', 'D12.776.660.720.485',... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: retrospective diagnosis by PCR using Guthrie cards. | We report on two patients with congenital cytomegalovirus (CMV) infection asymptomatic at birth that was diagnosed retrospectively by polymerase chain reaction (PCR) of CMV DNA using blood stored on Guthrie cards. Neuroimaging studies showed abnormal myelination without any gray matter abnormalities. In the differentia... | ['Blood Specimen Collection', 'Brain', 'Child', 'Child, Preschool', 'Cytomegalovirus', 'Cytomegalovirus Infections', 'DNA, Viral', 'Diagnosis, Differential', 'Female', 'Hearing Loss, Sensorineural', 'Humans', 'Magnetic Resonance Imaging'] | 12,427,519 | [['E01.370.225.998.110', 'E04.665.150', 'E05.200.998.110'], ['A08.186.211'], ['M01.060.406'], ['M01.060.406.448'], ['B04.280.382.150.150'], ['C01.925.256.466.245'], ['D13.444.308.568'], ['E01.171'], ['C09.218.458.341.887', 'C10.597.751.418.341.887', 'C23.888.592.763.393.341.887'], ['B01.050.150.900.649.313.988.400.112.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of stuttering severity and therapy involvement on role entrapment of people who stutter. | The primary purpose of this study was to examine whether a group of university students would report role entrapment of people who stutter (PWS) in the form of occupational stereotyping. The study also examined whether severity of stuttering (mild or severe) and level of therapy involvement (choosing or not choosing to... | ['Adult', 'Career Choice', 'Female', 'Humans', 'Male', 'Middle Aged', 'Role', 'Self Concept', 'Severity of Illness Index', 'Speech Therapy', 'Stuttering'] | 17,931,648 | [['M01.060.116'], ['F02.463.785.373.346.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.829.316.616'], ['F01.752.747.792'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500'], ['E02.760.169.063.500.727.552', 'E02.831.727.5... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Defining the plasmid-borne restriction-modification systems of the Lyme disease spirochete Borrelia burgdorferi. | The restriction-modification (R-M) systems of many bacteria present a barrier to the stable introduction of foreign DNA. The Lyme disease spirochete Borrelia burgdorferi has two plasmid-borne putative R-M genes, bbe02 and bbq67, whose presence limits transformation by shuttle vector DNA from Escherichia coli. We show t... | ['Animals', 'Base Sequence', 'Borrelia burgdorferi', 'DNA Methylation', 'DNA Restriction-Modification Enzymes', 'DNA, Bacterial', 'Gene Expression Regulation, Bacterial', 'Gene Transfer, Horizontal', 'Humans', 'Lyme Disease', 'Mice', 'Mice, Inbred C3H', 'Molecular Sequence Data', 'Mutation', 'Plasmids'] | 21,193,609 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B03.440.425.410.711.193.150.125', 'B03.851.595.193.150.125'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D08.811.150'], ['D13.444.308.212'], ['G05.308.300'], ['G05.728.390'], ['B01.050.150.900.649.313.988.400.112.400... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A Systematic Study on Reproductive Endocrine Function Recovery From Subcutaneous Ovarian Autotransplantation in Mice After 2 Weeks. | BACKGROUND: Heterotopic ovarian transplantation can not only restore the reproductive and endocrine function of animals but can also be studied with a specialized animal model. The aim of the study was to determine whether the reproductive endocrine function of the subcutaneously transplanted ovary was restored after 2... | ['Animals', 'Female', 'Mice', 'Ovary', 'Transplantation, Autologous', 'Transplantation, Heterotopic'] | 31,303,411 | [['B01.050'], ['B01.050.150.900.649.313.992.635.505.500'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['E04.936.664'], ['E04.936.800']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[HL-A D antigens from B-lymphocytes and susceptibility to certain diseases]. | The discovery of many associations between HLA and human diseases has emphasized the biologic importance of the main histocompatibility system in man. The recent findings from specific immune response genes (Ir locus) mapping within the H2 region of the mouse have led to systematic study of the similar D locus mapping ... | ['B-Lymphocytes', 'Chromosome Mapping', 'Diabetes Mellitus, Type 1', 'HLA Antigens', 'Humans', 'Immunogenetics', 'Leukemia, Lymphoid', 'Multiple Sclerosis', 'Rhinitis, Allergic, Seasonal'] | 303,374 | [['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['E05.393.183'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['D23.050.301.500.450', 'D23.050.705.552.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.273.343.420'], ['C0... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Alpha4beta2 nicotinic receptor stimulation contributes to the effects of nicotine in the DBA/2 mouse model of sensory gating. | RATIONALE: Nicotine improves the deficiencies of sensory gating function in schizophrenic patients and in dilute brown non-Agouti (DBA/2) mice. This effect of nicotine has been attributed to activation of the alpha7 nicotinic acetylcholine receptor (nAChR) subtype.OBJECTIVE: The aim of this study was to determine wheth... | ['Animals', 'Dihydro-beta-Erythroidine', 'Dose-Response Relationship, Drug', 'Evoked Potentials, Auditory', 'Hippocampus', 'Mecamylamine', 'Mental Processes', 'Mice', 'Mice, Inbred DBA', 'Nicotine', 'Receptors, Nicotinic', 'Schizophrenia'] | 16,767,415 | [['B01.050'], ['D03.132.285', 'D03.633.400.380'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.265.216.500.370', 'G07.888.250', 'G11.561.200.500.370'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['D02.455.426.100.080.550.500', 'D04.075.080.500.500'], ['F02.463'], ['B01.050.150.900.649.313.992.635.505.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Factors Contributing Successful Ultrasound-guided Radial Artery Cannulation and Its Complications When Using the Short-axis Out-of-plane Procedure]. | Objective To identify the possible factors that may influence the success and the complications of ultrasound-guided out-of-plane radial arterial cannulation. Methods Multivariate Logistic regression analysis was used to analyze the clinical data of 131 patients undergoing elective surgery and ultrasound-guided out-of-... | ['Catheterization, Peripheral', 'Elective Surgical Procedures', 'Humans', 'Logistic Models', 'Multivariate Analysis', 'Radial Artery', 'Ultrasonography, Interventional'] | 32,131,945 | [['E02.148.224', 'E04.100.814.529.937', 'E04.502.382.937', 'E05.157.375'], ['E04.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695.470', 'N06.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Protective Effect of Val129 | Bovine spongiform encephalopathy (BSE) is the only known zoonotic prion that causes variant Creutzfeldt-Jakob disease (vCJD) in humans. The major risk determinant for this disease is the polymorphic codon 129 of the human prion protein (Hu-PrP), where either methionine (Met129) or valine (Val129) can be encoded. To dat... | ['Amino Acid Substitution', 'Animals', 'Brain', 'Cattle', 'Codon', 'Creutzfeldt-Jakob Syndrome', 'Disease Resistance', 'Encephalopathy, Bovine Spongiform', 'Gene Expression', 'Humans', 'Injections, Intraventricular', 'Methionine', 'Mice', 'Mice, Transgenic', 'Peptide Hydrolases', 'Prion Proteins', 'Valine'] | 28,820,136 | [['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['A08.186.211'], ['B01.050.150.900.649.313.500.380.271'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['C01.207.800.230', 'C10.228.140.380.165', 'C10.228.228.800.230', 'F03.615.400.300'], ['C23.550.291.671', 'G12.450.564.250', 'G12.450... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CCND2 polymorphisms associated with clearance of HBV infection. | Cyclin D2s (CCND2s) are members of the D-type cyclin family. They interact and construct complexes with cyclin-dependent kinase (CDK)4 or 6. The cyclin D2/CDK4 or CDK6 complexes have key roles in controlling the progression of cell cycle from the Gap 1 (G1) phase to the synthesis (S) phase. Overexpression of cyclin D2 ... | ['Adult', 'Age of Onset', 'Aged', 'Asian Continental Ancestry Group', 'Carcinoma, Hepatocellular', 'Chromosome Mapping', 'Cyclin D2', 'Female', 'Haplotypes', 'Hepatitis B', 'Hepatitis B virus', 'Humans', 'Liver Neoplasms', 'Logistic Models', 'Male', 'Middle Aged', 'Polymorphism, Single Nucleotide', 'Proportional Hazard... | 20,414,251 | [['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['M01.686.508.200'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E05.393.183'], ['D12.644.360.262.150.200', 'D12.776.167.218.150.200', 'D12.776.476.262.150.200'], ['G05.380.360'], ['C01... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Diffusion of digital breast tomosynthesis among women in primary care: associations with insurance type. | Digital breast tomosynthesis (DBT) has shown potential to improve breast cancer screening and diagnosis compared to digital mammography (DM). The FDA approved DBT use in conjunction with conventional DM in 2011, but coverage was approved by CMS recently in 2015. Given changes in coverage policies, it is important to mo... | ['Adult', 'Aged', 'Aged, 80 and over', 'Breast Neoplasms', 'Early Detection of Cancer', 'Female', 'Humans', 'Insurance, Health', 'Mammography', 'Medicaid', 'Medicare', 'Middle Aged', 'Primary Health Care', 'United States'] | 28,378,409 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.180', 'C17.800.090.500'], ['E01.390.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.343'], ['E01.370.350.700.500'], ['N03.219.521.346.506.564.655', 'N03.706.615.693'], ['N03.219.521.346.506.564.663', 'N03.219.521.576.343... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Ageing: research in Spain and Europe]. | Researchers, stakeholders and policy makers agree about the importance of the population ageing in modern societies, so a broad analysis of current research strategies is in progress, such as FUTURAGE, a network for drawing a map for future research on ageing. This document presents the Spanish contribution to this map... | ['Aging', 'Biomedical Research', 'Europe', 'Humans', 'Spain'] | 22,578,385 | [['G07.345.124'], ['H01.770.644.145'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.846']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Impact of chromatin structure on sequence variability in the human genome. | DNA sequence variations in individual genomes give rise to different phenotypes within the same species. One mechanism in this process is the alteration of chromatin structure due to sequence variation that influences gene regulation. We composed a high-confidence collection of human single-nucleotide polymorphisms and... | ['Chromatin', 'Epigenesis, Genetic', 'Genome, Human', 'Humans', 'Polymorphism, Single Nucleotide'] | 21,399,641 | [['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['G05.308.203'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795.598']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepsy. | PURPOSE: This study examined the hypothesis that neurodegeneration continues after status epilepticus (SE) ends and that the severity of damage at the early phase of the epileptogenic process predicts the outcome of epilepsy in a long-term follow-up.METHODS: SE was induced in rats by electrical stimulation of the amygd... | ['Amygdala', 'Animals', 'Brain', 'Electric Stimulation', 'Electroencephalography', 'Epilepsy, Temporal Lobe', 'Follow-Up Studies', 'Hippocampus', 'Longitudinal Studies', 'Magnetic Resonance Imaging', 'Male', 'Monitoring, Physiologic', 'Nerve Degeneration', 'Rats', 'Rats, Sprague-Dawley', 'Severity of Illness Index', 'S... | 15,329,065 | [['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['B01.050'], ['A08.186.211'], ['E05.723.402'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490.360.290', 'C10.228.140.490.493.375'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A08.186.211.180.405', '... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Molecular characterization of Anaplasma marginale in ticks naturally feeding on buffaloes. | Anaplasma marginale is the most prevalent pathogen transmitted by ticks in cattle in tropical and subtropical regions of the world. However, the tick species involved in the transmission of A. marginale in buffaloes in Brazil have not been identified. The objective of the present study was to determine the presence of ... | ['Anaplasma marginale', 'Anaplasmosis', 'Animals', 'Brazil', 'Buffaloes', 'Cattle', 'Ixodidae', 'Phylogeny', 'Tick Infestations'] | 26,209,411 | [['B03.440.664.750.050.500', 'B03.660.050.783.500.050.500'], ['C01.150.252.400.054.500', 'C01.150.252.400.082', 'C01.920.930.163', 'C22.085'], ['B01.050'], ['Z01.107.757.176'], ['B01.050.150.900.649.313.500.380.135'], ['B01.050.150.900.649.313.500.380.271'], ['B01.050.500.131.166.132.832.400'], ['G05.697', 'G16.075.605... | ['Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
A model system for detection and isolation of a tumor cell surface antigen using antibody phage display. | To establish a screening procedure for tumor cell-surface reactive Fabs, we used a model antigen/antibody system including the epidermal growth factor receptor (EGF-R) and the anti-EGF-R monoclonal antibody 425. The 425 Fab was displayed on the surface of M13 filamentous phage. In a screening assay for 425 phage bindin... | ['Adenocarcinoma', 'Antibodies, Anti-Idiotypic', 'Antibodies, Monoclonal', 'Antigens, Neoplasm', 'Antigens, Surface', 'Bacteriophage M13', 'Binding Sites, Antibody', 'ErbB Receptors', 'Humans', 'Immunoglobulin Fab Fragments', 'Melanoma', 'Models, Immunological', 'Protein Binding', 'Tumor Cells, Cultured'] | 9,134,026 | [['C04.557.470.200.025'], ['D12.776.124.486.485.114.071', 'D12.776.124.790.651.114.071', 'D12.776.377.715.548.114.071'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.285'], ['D23.050.301'], ['B04.123.205.250', 'B04.123.370.400.250', 'B04.280.400.400.250'], ['G... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of genetic variant (rs11887534) in ABCG8 gene in coronary artery disease and response to atorvastatin therapy. | BACKGROUND: ATP-binding cassette transporter ABCG8 plays an important role in excretion of cholesterol from liver. Common genetic polymorphisms in ABCG8 gene may genetically predispose an individual to coronary artery disease (CAD) along with response to atorvastatin therapy. Thus, we aimed to examine the role of ABCG8... | ['ATP Binding Cassette Transporter, Subfamily G, Member 8', 'ATP-Binding Cassette Transporters', 'Anticholesteremic Agents', 'Atorvastatin', 'Case-Control Studies', 'Coronary Artery Disease', 'Female', 'Genetic Predisposition to Disease', 'Genotype', 'Heptanoic Acids', 'Humans', 'Lipids', 'Male', 'Middle Aged', 'Polyme... | 20,592,455 | [['D10.532.160', 'D12.776.157.530.100.228.875', 'D12.776.395.550.020.457.875', 'D12.776.521.212', 'D12.776.543.550.192.457.875', 'D12.776.543.585.100.228.875'], ['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['D27.505.519.186.071.202', 'D27.505.954.557.500.202'], ['D03.383... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An ontology of bacteria to help physicians to compare antibacterial spectra. | General practitioners (GPs) may lack specialist microbiological knowledge, making it difficult for them to use documents concerning antibacterial spectra provided by French health authorities. We have developed a tool to help GPs to compare antibacterial spectra, based on an ontology of bacteria generated using OWL-DL ... | ['Anti-Bacterial Agents', 'Bacteria', 'Family Practice', 'France', 'Humans', 'Microbial Sensitivity Tests', 'Microbiology', 'Vocabulary, Controlled'] | 18,693,825 | [['D27.505.954.122.085'], ['B03'], ['H02.403.340.500'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['H01.158.273.540'], ['L01.453.245.945']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
Periprocedural prophylactic antithrombotic strategies in interventional radiology: current practice in the Netherlands and comparison with the United kingdom. | PURPOSE: The use of prophylactic antithrombotic drugs to prevent arterial thrombosis during the periprocedural period during (percutaneous) peripheral arterial interventions (PAIs) is still a matter of dispute, and clear evidence-based guidelines are lacking. To create those guidelines, a study group was formed in the ... | ['Clopidogrel', 'Fibrinolytic Agents', 'Heparin', 'Humans', 'Netherlands', 'Perioperative Care', "Practice Patterns, Physicians'", 'Radiology, Interventional', 'Stents', 'Surveys and Questionnaires', 'Thrombosis', 'Ticlopidine', 'United Kingdom', 'Vascular Surgical Procedures'] | 23,404,518 | [['D02.886.778.823.500.500', 'D03.383.725.849.500.500', 'D03.383.903.830.500.500', 'D03.633.100.928.500.500'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.651'], ['E02.760.731', 'E04.604', 'N02.421.585.722'], ['N0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
The first subcomponent of complement, C1q, triggers the production of IL-8, IL-6, and monocyte chemoattractant peptide-1 by human umbilical vein endothelial cells. | We and others have demonstrated previously the occurrence of cC1qR/CaR, a receptor for the collagen-like stalks of complement component C1q, on endothelial cells. In the present study we investigated whether binding of C1q to endothelial cells resulted in enhancement of cytokine or chemokine production. HUVEC produced ... | ['Animals', 'Antibodies, Monoclonal', 'Calcium-Binding Proteins', 'Calreticulin', 'Cells, Cultured', 'Chemokine CCL2', 'Complement C1q', 'Complement Factor H', 'Cycloheximide', 'Dose-Response Relationship, Immunologic', 'Endothelium, Vascular', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Immunoglobulin Fab Fragment... | 9,862,726 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.157.125'], ['D12.644.360.372.374', 'D12.776.157.125.412.374', 'D12.776.476.387.374', 'D12.776.503.303'], ['A11.251'], ['D12.644.276.374.200.110.990.600', 'D12.776.467.374.200.110.990.600', 'D23.125.300... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Low-dose immunization with adenovirus expressing the thyroid-stimulating hormone receptor A-subunit deviates the antibody response toward that of autoantibodies in human Graves' disease. | Immunization with adenovirus expressing the TSH receptor (TSHR) induces hyperthyroidism in 25-50% of mice. Even more effective is immunization with a TSHR A-subunit adenovirus (65-84% hyperthyroidism). Nevertheless, TSHR antibody characteristics in these mice do not mimic accurately those of autoantibodies in typical G... | ['Adenoviridae', 'Animals', 'Autoantibodies', 'Disease Models, Animal', 'Female', 'Glycoprotein Hormones, alpha Subunit', 'Graves Disease', 'Humans', 'Immunization', 'Immunoglobulins, Thyroid-Stimulating', 'Mice', 'Mice, Inbred BALB C', 'T-Lymphocytes', 'Virion'] | 14,576,177 | [['B04.280.030'], ['B01.050'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D06.472.699.322.326.562', 'D06.472.699.322.576.288.750', 'D06.472.699.322.576.463.249', 'D06.472.699.631.525.343.288.750', 'D06.472.699.631.525.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Flagellar filament structural protein induces Sj?gren's syndrome-like sialadenitis in mice. | OBJECTIVE: Sj?gren's syndrome (SS) is a systemic autoimmune disease that primarily affects lacrimal and salivary glands. We previously reported that FliC derived from Escherichia coli could induce autoimmune pancreatitis-like lesions. From these results, we speculated that FliC could also induce SS-like exocrinopathy. ... | ['Animals', 'Autoantibodies', 'Escherichia coli Proteins', 'Female', 'Flagellin', 'Immunoglobulin G', 'Interleukins', 'Mice', 'Ribonucleoproteins', 'Sialadenitis', "Sjogren's Syndrome"] | 28,142,222 | [['B01.050'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D12.776.097.275'], ['D12.776.097.380'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['D12.644.276.374.465', 'D12.776.467.374.465', 'D23.529.374.46... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Defining displacement thresholds for surgical intervention for distal radius fractures - A Delphi study. | Distal radius fractures are very common yet controversy exists regarding which require treatment and is reflected by significant variation in surgical intervention rate. Evidence regarding which fractures would benefit from intervention is varied and largely poor quality. This study had three aims; identify which radio... | ['Adult', 'Aged', 'Delphi Technique', 'Female', 'Humans', 'Intra-Articular Fractures', 'Male', 'Middle Aged', 'Radius Fractures', 'Surveys and Questionnaires'] | 30,620,763 | [['M01.060.116'], ['M01.060.116.100'], ['L01.906.197'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.404.505'], ['M01.060.116.630'], ['C26.088.268.556', 'C26.404.562'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Simultaneous quantification of 11 active constituents in Shexiang Baoxin Pill by ultraperformance convergence chromatography combined with tandem mass spectrometry. | On account of the complexity of chemical constituents of Shexiang Baoxin Pill (SBP), a famous traditional Chinese medicine (TCM) formula, a novel and effective UPC2-MS/MS method was developed to simultaneously determine the content of 11 active compounds of SBP with outstanding separation ability. Eleven components in ... | ['Bile Acids and Salts', 'Bufanolides', 'Chromatography, High Pressure Liquid', 'Drugs, Chinese Herbal', 'Ginsenosides', 'Limit of Detection', 'Quality Control', 'Reproducibility of Results', 'Tandem Mass Spectrometry', 'Volatile Organic Compounds'] | 28,384,605 | [['D04.210.500.105'], ['D04.210.500.155.580.064'], ['E05.196.181.400.300'], ['D20.215.784.500.350', 'D26.335'], ['D02.455.849.919.277', 'D09.408.782.300'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['J01.897.608'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.5... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Applying guidance for methane emission estimation for landfills. | Quantification of methane emission from landfills is important to evaluate measures for reduction of greenhouse gas emissions. Both the United Nations and the European Union have adopted protocols to ensure quantification of methane emission from individual landfills. The purpose of these protocols is to disclose emiss... | ['Air Pollutants', 'Environmental Monitoring', 'Europe', 'Guidelines as Topic', 'Methane', 'Models, Theoretical', 'Refuse Disposal', 'United Nations'] | 16,442,791 | [['D27.888.284.101'], ['N06.850.460.350.080', 'N06.850.780.375'], ['Z01.542'], ['N04.761.700.350', 'N05.700.350'], ['D02.455.326.146.571'], ['E05.599'], ['N06.850.780.200.800.800.700', 'N06.850.860.510.900.600'], ['N03.540.514.718']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Estimation of postmortem interval using kinetic analysis of the third component of complement (C3) cleavage. | To estimate postmortem interval (PMI), spontaneous cleavage of the third component of complement (C3) was studied in aged blood and cadaveric blood by crossed immunoelectrophoresis. Using the kinetics of C3 cleavage in vitro described as dC/dt = -kC, where C is the concentration of native C3 at time t and k is a first-... | ['Blood Protein Electrophoresis', 'Cause of Death', 'Complement C3', 'Forensic Medicine', 'Humans', 'Postmortem Changes', 'Temperature', 'Time Factors'] | 2,918,280 | [['E01.370.225.124.100.110', 'E05.196.401.076', 'E05.200.124.100.110', 'E05.301.300.049'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['D12.776.124.050.140', 'D12.776.124.486.274.250'], ['H02.403.330', 'I01.198.780.937'], ['B01.050.150.900.649.313.9... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
[Abundance and morphometry of tuberculosa Anadara and A. similis (Mollusca: Bivalvia) in the Manglar de Purruja, Dulce Gulf, Costa Rica]. | The density, population, length, yield and sex proportion of the mollusks Anadara tuberculosa and A. similis were studied in Bah?a de Golfito, Golfo Dulce, Pacific coast of Costa Rica from February 1998 to February 1999. A. tuberculosa was more abundant (0.9 units m(-2)), than A. similis (0.2 units m(-2)); the highest ... | ['Animals', 'Body Weight', 'Costa Rica', 'Female', 'Male', 'Mollusca', 'Population Density', 'Sex Distribution', 'Trees'] | 15,264,545 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['Z01.107.169.238'], ['B01.050.500.644'], ['N01.224.600', 'N06.850.505.400.600'], ['I01.240.800', 'N01.224.803', 'N06.850.505.400.850'], ['B01.650.915']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
[Preoperative sedation with dexmedetomidine in patients with aneurysmal subarachnoid hemorrhage]. | BACKGROUND: Dexmedetomidine could be beneficial for preoperative sedation of patients with aneurysmal subarachnoid hemorrhage (SAH) because of its sympathetic suppressive effect without respiratory depression.METHODS: Thirteen patients were sedated with continuous intravenous administration of dexmedetomidine (group D)... | ['Adrenergic alpha-Agonists', 'Adult', 'Aged', 'Aged, 80 and over', 'Anesthesia, General', 'Conscious Sedation', 'Dexmedetomidine', 'Diazepam', 'Female', 'Humans', 'Hypnotics and Sedatives', 'Infusions, Intravenous', 'Intracranial Aneurysm', 'Male', 'Middle Aged', 'Pentazocine', 'Preanesthetic Medication', 'Subarachnoi... | 16,440,707 | [['D27.505.519.625.050.100.100', 'D27.505.696.577.050.100.100'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E03.155.197'], ['E03.250'], ['D03.383.129.308.245'], ['D03.633.100.079.080.070.216'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.277.350', 'D27.505.954.427.210.350'], ['E... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
On the use of age-intensity data to detect immunity to parasitic infections, with special reference to Schistosoma mansoni in Kenya. | We consider two phenomena, related to the host age-intensity profiles of parasitic infections, which have been suggested to be indicative of acquired immunity: (i) a lower age of peak intensity among more intensely infected hosts; and (ii) a decline with age in the dispersion of the distribution of parasites between ho... | ['Adolescent', 'Age Factors', 'Animals', 'Child', 'Feces', 'Humans', 'Immunity, Active', 'Kenya', 'Models, Biological', 'Parasite Egg Count', 'Parasitic Diseases', 'Prevalence', 'Regression Analysis', 'Schistosoma mansoni', 'Schistosomiasis mansoni'] | 1,454,421 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['M01.060.406'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.050.370'], ['Z01.058.290.120.400'], ['E05.599.395'], ['E01.370.225.932.600', 'E05.200.932.600'], ['C01.610'], ['E05.318.308.985.525.750', 'N01.224.935.597.750',... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles. | RNA editing at the Q/R site near the apex of the pore loop of AMPA and kainate receptors controls a diverse array of channel properties, including ion selectivity and unitary conductance and susceptibility to inhibition by polyamines and cis-unsaturated fatty acids, as well as subunit assembly into tetramers and regula... | ['Action Potentials', 'Amino Acid Sequence', 'Amino Acid Substitution', 'Binding Sites', 'Fatty Acids', 'HEK293 Cells', 'Humans', 'Ion Channel Gating', 'Molecular Sequence Data', 'Mutation', 'Protein Binding', 'Protein Structure, Tertiary', 'Receptors, Kainic Acid', 'Thermodynamics'] | 23,940,260 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.420.601.035', 'G05.558.109'], ['G02.111.570.120'], ['D10.251'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.820.400', 'G04.835.400', 'G07.265.625'], ['L01.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A randomized assessment of adding the kinase inhibitor lestaurtinib to first-line chemotherapy for FLT3-mutated AML. | The clinical benefit of adding FMS-like tyrosine kinase-3 (FLT3)-directed small molecule therapy to standard first-line treatment of acute myeloid leukemia (AML) has not yet been established. As part of the UK AML15 and AML17 trials, patients with previously untreated AML and confirmed FLT3-activating mutations, mostly... | ['Adolescent', 'Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Carbazoles', 'Child', 'Child, Preschool', 'Consolidation Chemotherapy', 'Disease-Free Survival', 'Female', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Induction Chemotherapy', 'Kaplan-Meier Estimate', 'Leukemia, Myeloid, Acute'... | 27,872,058 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D03.633.100.473.144', 'D03.633.300.148'], ['M01.060.406'], ['M01.060.406.448'], ['E02.319.218'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Progress in endocrine therapy for early breast cancer]. | Breast cancer is a malignant tumor that occurs in the epithelial tissues of the breast gland. The cause of the disease is not fully understood and may be related to genetic, endocrine and other factors. For estrogen or progesterone receptor-positive early breast cancer, endocrine therapy is efficient, simple, and fewer... | ['Breast Neoplasms', 'Humans', 'Receptors, Estrogen'] | 31,919,322 | [['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.826.750.350', 'D12.776.930.778.350']] | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of an otoscopy simulator to teach otoscopy and normative anatomy to first year medical students. | OBJECTIVE/HYPOTHESIS: Our study evaluates the effectiveness of the OtoSim as an educational tool for teaching otoscopy and normal middle ear anatomy to first-year medical students.STUDY DESIGN: Cross-sectional survey design.METHODS: A large group otoscopy simulator teaching session was held in January 2014 for 29 first... | ['Clinical Competence', 'Computer Simulation', 'Cross-Sectional Studies', 'Ear, Middle', 'Education, Medical, Undergraduate', 'Educational Measurement', 'Humans', 'Learning', 'Ontario', 'Otolaryngology', 'Otoscopy', 'Reproducibility of Results', 'Retrospective Studies', 'Students, Medical'] | 25,601,719 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['L01.224.160'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['A09.246.397'], ['I02.358.399.450'], ['I02.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['Z01.107.567.176.639'], ['H02.403.8... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Named Groups [M... | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
The scientific claims of British child guidance, 1918-45. | This article examines the British child guidance movement's claim to scientific status and what it sought to gain by the wider acceptance of such a claim. The period covered is from the movement's origins in the 1920s to the end of the Second World War, by which point it had been incorporated into the welfare state. Th... | ['Child', 'Child Guidance', 'Child Psychiatry', 'Child, Preschool', 'History, 20th Century', 'Humans', 'Mental Health', 'United Kingdom'] | 20,027,910 | [['M01.060.406'], ['F02.784.629.272', 'F04.408.192'], ['F04.096.544.193', 'H02.403.690.130'], ['M01.060.406.448'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.418', 'N01.400.500'], ['Z01.542.363']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Humanities [K]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
[Acute cholecystitis in choledocholithiasis and stricture of the ampulla of Vater]. | The work is based on the examination of 106 patients, operated in the clinic for acute cholecystitis associated with choledocholithiasis and strictures of Vater's papilla. The operation of choice is a removal of pathologically changed gallbladder, elimination of the cause of cholestasis with restoration of bile passage... | ['Acute Disease', 'Cholecystitis', 'Cholelithiasis', 'Constriction', 'Duodenal Diseases', 'Humans', 'Methods'] | 855,107 | [['C23.550.291.125'], ['C06.130.564.263'], ['C06.130.409'], ['E05.225'], ['C06.405.469.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anaesthesia for an adult with Angelman syndrome. | Angelman syndrome is a complex genetic condition involving abnormalities of chromosome 15 in the majority of cases. These defects involve a gene encoding an ubiquitin protein ligase and may be associated with abnormal gamma-aminobutyric acid (GABA)(A) receptor subunits. Angelman syndrome may have profound implications ... | ['Adult', 'Anesthesia, General', 'Angelman Syndrome', 'Dental Care', 'Female', 'Humans', 'Muscle Hypertonia', 'Respiratory Insufficiency'] | 19,825,063 | [['M01.060.116'], ['E03.155.197'], ['C10.228.662.075', 'C16.131.077.095', 'C16.131.260.040', 'C16.320.180.040'], ['E06.170', 'N02.421.240.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.613.550', 'C23.888.592.608.550'], ['C08.618.846']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Combined directed ortho metalation/cross-coupling strategies: synthesis of the tetracyclic A/B/C/D ring core of the antitumor agent camptothecin. | A convergent synthesis of the A/B/C/D ring fragment 5 of camptothecin using a combination of directed ortho metalation and Negishi cross-coupling is described. The key features of the synthetic sequence are an anionic ortho-Fries rearrangement (10 --> 12), a Negishi cross-coupling (7 --> 6), and a terminal modified von... | ['Antineoplastic Agents, Phytogenic', 'Camptothecin', 'Catalysis', 'Molecular Structure', 'Nuclear Magnetic Resonance, Biomolecular'] | 15,527,256 | [['D27.505.954.248.179'], ['D03.132.151'], ['G02.130'], ['G02.111.570', 'G02.466'], ['E05.196.867.519.550']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quadrivalent meningococcal vaccines: hyporesponsiveness as an important consideration when choosing between the use of conjugate vaccine or polysaccharide vaccine. | Regional variations in the incidence and the distribution of serogroups which are responsible of meningococcal disease necessitate multivalent vaccines to ensure broad coverage for travelers. For almost 30 years, this has been provided by quadrivalent polysaccharide vaccine to protect against serogroups A, C, W-135 and... | ['Adolescent', 'Adult', 'Antibodies, Bacterial', 'Child', 'Child, Preschool', 'Humans', 'Immunization, Secondary', 'Infant', 'Meningitis, Meningococcal', 'Meningococcal Vaccines', 'Serotyping', 'Vaccines, Conjugate'] | 20,188,306 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.400.485', 'E05.478.550.550'], ['M01.060.703'], ['C01.150.252.223.500.750', 'C01.150.2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Analysis of transfer RNA during the early embryogenesis of the freshwater teleost, Heteropneustes fossilis. | Total RNA as well as transfer RNA were quantified from mature ova apart from four different embryonic stages namely mid-cleavage, early gastrula, mid-gastrula and organogenesis of the freshwater teleost Heteropneustes fossilis. Total RNA as well as transfer RNA quantity follow a similar variation pattern, being maximum... | ['Animals', 'Catfishes', 'Chromatography, High Pressure Liquid', 'Embryo, Nonmammalian', 'RNA, Transfer'] | 8,531,921 | [['B01.050'], ['B01.050.150.900.493.080'], ['E05.196.181.400.300'], ['A13.350', 'A16.331'], ['D13.444.735.757']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mesalazine-probiotics beads for acetic acid experimental colitis: formulation and characterization of a promising new therapeutic strategy for ulcerative colitis. | BACKGROUND: Acetic acid ulcerative colitis (UC) is an experimental condition created due to intra-rectal administration of acetic acid which causes inflammation and ulceration in the lining of colon and rectum. In such condition, the colon cannot absorb liquid from the stools, resulting in larger volume of watery stool... | ['Acetic Acid', 'Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Cell Survival', 'Colitis, Ulcerative', 'Colon', 'Delayed-Action Preparations', 'Disease Models, Animal', 'Drug Carriers', 'Drug Delivery Systems', 'Drug Liberation', 'Male', 'Mesalamine', 'Particle Size', 'Pectins', 'Probiotics', 'Rats', 'Rats, Wist... | 24,491,122 | [['D02.241.081.018.165', 'D10.251.400.045.500'], ['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['G04.346'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D26.255.210', ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Association between vitamin D receptor poly(A) polymorphism and breast cancer risk: a meta-analysis. | Vitamin D receptor (VDR) poly(A) is a common genetic polymorphism in the VDR gene, and it has been implicated to be associated with breast cancer risk. However, previous studies on the association reported inconclusive results. We performed this meta-analysis to comprehensively assess the association. Eligible studies ... | ['Breast Neoplasms', 'Case-Control Studies', 'Female', 'Genetic Association Studies', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Odds Ratio', 'Poly A', 'Polymorphism, Single Nucleotide', 'Publication Bias', 'Receptors, Calcitriol', 'Risk'] | 24,037,913 | [['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.393.385'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.600', 'G17.680.500', 'N05.715.360.750.625.590', 'N06.850.520.830.60... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. | While memory T cells are maintained by continuous turnover, it is not clear how human regulatory CD4+ CD45RO+ CD25hi Foxp3+ T lymphocyte populations persist throughout life. We therefore used deuterium labeling of cycling cells in vivo to determine whether these cells could be replenished by proliferation. We found tha... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antigens, CD', 'CD4 Antigens', 'Cell Cycle', 'Dipeptidyl Peptidase 4', 'Female', 'Flow Cytometry', 'Humans', 'Immunologic Memory', 'Immunophenotyping', 'Leukocyte Common Antigens', 'Lymphocyte Activation', 'Male', 'Middle Aged', 'Receptors, Antigen, T-Cell', 'T-Lymphocyte Subsets... | 16,955,142 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D12.776.543.750.705.852.420.810.500', 'D12.776.543.750.830.700.025', 'D23.050.301.264.894.100', 'D23.101.100.894.100'], ['G04.144'], ['D08.811.277.656.350.350.126', 'D08.811.277.656.959.250', 'D23.050.301.264.8... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Galactosemia: clinical features, diagnosis and management. A case report. | The case report and discussion presented here were prepared in response to legislation in Louisiana which requires that the Dept of Health and Hospitals establish a program to inform physicians and hospitals of the current medical standards for the diagnosis, clinical management, and recognition of galactosemia. Classi... | ['Diagnosis, Differential', 'Education, Medical, Continuing', 'Galactosemias', 'Humans', 'Infant, Newborn', 'Male'] | 7,642,981 | [['E01.171'], ['I02.358.212.350', 'I02.358.399.250'], ['C10.228.140.163.100.320', 'C16.320.565.189.320', 'C16.320.565.202.355', 'C18.452.132.100.320', 'C18.452.648.189.320', 'C18.452.648.202.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
The Quality of Information on Combined Oral Contraceptives Available on the Internet. | OBJECTIVE: Combined oral contraceptives (COC) are a popular choice among women. The Internet is an accessible and popular source of information on contraception. The objective of this study was to evaluate the quality of online information on COC.METHODS: A quantitative content analysis was completed on websites contai... | ['Benchmarking', 'Canada', 'Consumer Health Information', 'Contraceptives, Oral, Combined', 'Female', 'Humans', 'Internet'] | 31,003,948 | [['N04.452.500.150', 'N04.761.685.150', 'N04.761.700.150', 'N05.700.150', 'N05.715.360.650.150'], ['Z01.107.567.176'], ['I02.233.332.186', 'N02.421.726.407.229'], ['D26.310.360', 'D27.505.696.875.360.276.210.100', 'D27.505.954.705.360.276.210.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500... | ['Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease. | Farber disease is a rare lysosomal storage disease, characterized by the accumulation of ceramide in tissues due to acid ceramidase deficiency. Here we report the identification of three novel mutations in the acid ceramidase gene from two Japanese patients. Patient 1 showed joint problems at around 10 months of age an... | ['Animals', 'Base Sequence', 'COS Cells', 'Child', 'DNA Mutational Analysis', 'DNA, Complementary', 'Exons', 'Female', 'Galactosylgalactosylglucosylceramidase', 'Gene Expression', 'Humans', 'Japan', 'Lysosomal Storage Diseases', 'Male', 'Mutation', 'Mutation, Missense', 'Polymorphism, Genetic', 'Sequence Deletion'] | 12,638,942 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210.172.500', 'A11.329.228.220'], ['M01.060.406'], ['E05.393.760.700.300'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.360.340.024.340.137.232'], ['D08.811.277.450.410.150'], ['G05.297'], ['B01.0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 |
Different methods to estimate total power and its components during lifting. | A more fundamental understanding about the act of manual lifting can be provided by the assessment of the total production of power and the power generated in joints. The present study is concerned with the validity of the estimations of these parameters. Four subjects lifted an 18.8 kg load while they were filmed and ... | ['Adult', 'Biomechanical Phenomena', 'Humans', 'Male', 'Models, Biological', 'Weight Lifting'] | 1,517,270 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['I03.450.642.845.950']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
The significance of oligoclonal bands in multiple sclerosis in Japan: relevance of immunogenetic backgrounds. | We compared clinical and demographic features, MRI findings, and HLA profiles of 57 Japanese patients with multiple sclerosis (MS) between groups with and without oligoclonal IgG bands (OCB) in the cerebrospinal fluid (CSF). Patients with the optic-spinal form of MS (OpS-MS) or acute transverse myelopathy (ATM), which ... | ['Adult', 'Antibodies, Antinuclear', 'Female', 'HLA Antigens', 'HLA-DR2 Antigen', 'HLA-DR4 Antigen', 'Humans', 'Immunogenetics', 'Immunoglobulins', 'Male', 'Middle Aged', 'Multiple Sclerosis', 'Oligoclonal Bands'] | 9,702,693 | [['M01.060.116'], ['D12.776.124.486.485.114.323.204', 'D12.776.124.790.651.114.323.204', 'D12.776.377.715.548.114.323.204'], ['D23.050.301.500.450', 'D23.050.705.552.450'], ['D12.776.395.550.509.400.440.400.020', 'D12.776.543.550.440.400.440.400.020', 'D23.050.301.500.400.400.440.400.020', 'D23.050.301.500.450.400.440.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Quantitative analysis of histidine and cis and trans isomers of urocanic acid by high-performance liquid chromatography: a new assay method and its application. | To elucidate the factors involved in dry skin and the skin damage caused by UV light, it is necessary to analyze small amounts of stratum corneum to determine amino acid contents. A new assay method for this purpose is described. Dabsylated amino acids including histidine and the cis and trans isomers of urocanic acid ... | ['Chromatography, High Pressure Liquid', 'Histidine', 'Humans', 'Indicators and Reagents', 'Skin', 'Stereoisomerism', 'Sunburn', 'Urocanic Acid', 'p-Dimethylaminoazobenzene'] | 9,061,456 | [['E05.196.181.400.300'], ['D12.125.072.329', 'D12.125.142.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.410'], ['A17.815'], ['G02.607.445.682'], ['C17.800.600.725', 'C26.200.855'], ['D02.241.081.069.920', 'D03.383.129.308.960'], ['D02.092.146.325']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Folic acid-functionalized graphene oxide nanosheets via plasma etching as a platform to combine NIR anticancer phototherapy and targeted drug delivery. | PEGylated graphene oxide (GO) has shown potential as NIR converting agent to produce local heat useful in breast cancer therapy, since its suitable photothermal conversion, high stability in physiological fluids, biocompatibility and huge specific surface. GO is an appealing nanomaterial for potential clinical applicat... | ['Antineoplastic Agents', 'Cell Line', 'Cell Movement', 'Cell Survival', 'Doxorubicin', 'Drug Carriers', 'Drug Liberation', 'Folic Acid', 'Graphite', 'Humans', 'Infrared Rays', 'Nanostructures', 'Plasma Gases', 'Polyethylene Glycols'] | 31,761,243 | [['D27.505.954.248'], ['A11.251.210'], ['G04.198', 'G07.568.500.180'], ['G04.346'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['D26.255.260', 'E02.319.300.380'], ['G02.211', 'G03.787.321', 'G07.690.725.321'], ['D03.633.100.733.631.400'], ['D01.268.150.300', 'D01.578.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Chlamydia and gonorrhoea contamination of clinic surfaces. | INTRODUCTION: Nucleic acid amplification tests, with their ability to detect very small amounts of nucleic acid, have become the principle diagnostic tests for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) in many sexual health clinics. The aim of this study was to investigate the extent of surface contamin... | ['Ambulatory Care Facilities', 'Bacteriological Techniques', 'Chlamydia trachomatis', 'Environmental Microbiology', 'Female', 'Humans', 'Male', 'Neisseria gonorrhoeae', 'Nucleic Acid Amplification Techniques'] | 22,535,909 | [['N02.278.035'], ['E01.370.225.875.150', 'E05.200.875.150'], ['B03.440.190.190.190.750'], ['H01.158.273.540.274', 'N06.850.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.440.400.425.550.550.474', 'B03.660.075.525.520.400'], ['E05.393.620']] | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Spring ligament of the ankle: normal MR anatomy. | The plantar calcaneonavicular or spring ligament is visualized inconsistently and incompletely on routine MR images of the foot. This ligament is a vital stabilizer of the longitudinal arch of the foot, providing support for the head of the talus, which rests on the ligament's central portion. Laxity or rupture of the ... | ['Ankle', 'Foot', 'Humans', 'Ligaments', 'Magnetic Resonance Imaging'] | 8,249,733 | [['A01.378.610.050'], ['A01.378.610.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.513', 'A10.165.669'], ['E01.370.350.825.500']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
S. cerevisiae TFIIIB is the transcription initiation factor proper of RNA polymerase III, while TFIIIA and TFIIIC are assembly factors. | The S. cerevisiae RNA polymerase III (pol III) transcription factor TFIIIB binds to DNA upstream of the transcription start site of the SUP4 tRNA(Tyr) gene in a TFIIIC-dependent reaction and to the major 5S rRNA gene in a reaction requiring TFIIIC and TFIIIA. It is shown here that TFIIIB alone correctly positions pol I... | ['Base Sequence', 'DNA, Fungal', 'DNA-Directed RNA Polymerases', 'Deoxyribonuclease I', 'Fungal Proteins', 'Genes, Fungal', 'Molecular Sequence Data', 'Multigene Family', 'Plasmids', 'Potassium Permanganate', 'RNA Polymerase III', 'RNA, Ribosomal, 5S', 'RNA, Transfer, Tyr', 'Saccharomyces cerevisiae', 'Transcription Fa... | 2,404,611 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.300'], ['D08.811.913.696.445.735.270'], ['D08.811.277.352.335.350.250'], ['D12.776.354'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.500'], ['L01.453.245.667'], ['G05.360.340.024.340.645'], ['G05.360.600'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
pH-responsive vesicles based on a hydrolytically self-cross-linkable copolymer. | A new type of shape-persistent, pH-responsive vesicle was prepared by the self-assembly of a novel poly(ethylene oxide)-block-poly[2-(diethylamino)ethyl methacrylate-stat-3-(trimethoxysilyl)propyl methacrylate], PEO-b-P(DEA-stat-TMSPMA), copolymer. Vesicles were formed spontaneously in aqueous THF solution, with the hy... | ['Hydrogen-Ion Concentration', 'Hydrolysis', 'Methacrylates', 'Molecular Conformation', 'Nylons', 'Organosilicon Compounds', 'Polymers', 'Time Factors'] | 16,159,264 | [['G02.300'], ['G02.380'], ['D02.241.081.069.600'], ['G02.111.570.820'], ['D05.750.716.392', 'D25.720.716.392', 'J01.637.051.720.716.392', 'J01.637.548'], ['D02.756'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G01.910.857']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Research Note: Effect of diet with different proportions of ryegrass on breast meat quality of broiler geese. | This study was conducted to determine the effects of diet with different proportions of ryegrass on breast meat quality of geese. In total, 240 healthy male Yangzhou geese (28-day-old) with similar body weight were divided randomly into 4 diet groups (control group: fed commercial diets; treatment groups I, II, and III... | ['Animal Feed', 'Animals', 'Body Weight', 'Diet', 'Dietary Supplements', 'Dose-Response Relationship, Drug', 'Geese', 'Lolium', 'Male', 'Meat', 'Nutrients', 'Pectoralis Muscles', 'Random Allocation'] | 32,359,586 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G07.203.650.240'], ['G07.203.300.456', 'J02.500.456'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.248.050.350', 'B01.050.150.900... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
In vitro differentiation and mineralization of dental pulp stem cells on enamel-like fluorapatite surfaces. | Our previous studies have shown good biocompatibility of fluorapatite (FA) crystal surfaces in providing a favorable environment for functional cell-matrix interactions of human dental pulp stem cells (DPSCs) and also in supporting their long-term growth. The aim of the current study was to further investigate whether ... | ['Alkaline Phosphatase', 'Anthraquinones', 'Apatites', 'Calcification, Physiologic', 'Cell Differentiation', 'Cell Proliferation', 'Dental Enamel', 'Dental Pulp', 'Fluorescence', 'Humans', 'Osteogenesis', 'Polymerase Chain Reaction', 'Signal Transduction', 'Staining and Labeling', 'Stem Cells', 'Tetracycline'] | 22,563,788 | [['D08.811.277.352.650.035'], ['D02.455.426.559.847.117.159', 'D02.806.100', 'D04.615.117.159'], ['D01.029.260.700.675.374.075.025', 'D01.146.360.050', 'D01.578.122', 'D01.695.625.675.650.075.025'], ['G07.345.155.500', 'G07.345.500.325.377.625.050.500.175', 'G11.427.578.050.500.175'], ['G04.152'], ['G04.161.750', 'G07.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Living with hepatitis C: qualitative interviews with hepatitis C-infected veterans. | BACKGROUND: Chronic hepatitis C (HCV) infection affects millions of people in the USA and prevalence rates are higher in US veterans. The consequences of HCV infection include reduced quality of life, liver damage, and reduced longevity.OBJECTIVE: Our objective was to describe the experiences of US veterans living with... | ['Hepatitis C, Chronic', 'Humans', 'Interviews as Topic', 'Male', 'Middle Aged', 'Patient Education as Topic', 'Quality of Life', 'Self Care', 'United States', 'Veterans'] | 18,807,097 | [['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', 'C06.552.380.705.440.120'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['M01.060.116.630'], ['I02.233.332.500', 'N02.421.726.407.6... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Chronotherapy of colorectal cancer. | Chronotherapy consists of chemotherapy delivery according to circadian rhythms. These genetically based rhythms modulate cellular metabolism and cell proliferation in normal tissues. As a result, both the host tolerance and antitumor efficacy of 5-fluorouracil (5-FU) and oxaliplatin (L-OHP), like 30 other anticancer dr... | ['Animals', 'Antineoplastic Agents', 'Antineoplastic Combined Chemotherapy Protocols', 'Camptothecin', 'Carboplatin', 'Chronotherapy', 'Colorectal Neoplasms', 'Fluorouracil', 'Humans', 'Irinotecan', 'Leucovorin', 'Mice', 'Organoplatinum Compounds', 'Oxaliplatin', 'Radiotherapy, Adjuvant', 'Rats'] | 11,962,676 | [['B01.050'], ['D27.505.954.248'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D03.132.151'], ['D02.257.125'], ['E02.168'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['D03.383.742.698.875.404'], ['B01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Clinical Significance of Hepcidin in the Diagnosis of Infant Iron Deficiency Anemia]. | OBJECTIVE: To explore the clinical diagnostic value and significance of hepciden level by detecting the expression of serum hepcidin before and after treatment of infant iron deficiency anemia (IDA) with or without vitamin D deficiency.METHODS: A total of 60 cases of infamt IDA were divided into A and B groups, the gro... | ['Anemia, Iron-Deficiency', 'Case-Control Studies', 'Diagnosis, Differential', 'Enzyme-Linked Immunosorbent Assay', 'Hepcidins', 'Humans', 'Infant', 'Vitamin D Deficiency'] | 27,151,027 | [['C15.378.071.196.300', 'C18.452.565.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.171'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D12.776.494.249', 'D12.776.543.695.054.425'], ['B01.050.150.900.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Leupeptin does not affect the normal signal transduction mechanism in platelets. | Calpains are Ca2+-dependent serine proteases that can regulate protein kinase C-mediated cellular events by cleaving the membrane-bound native enzyme to yield an activated cytosolic fragment. Inhibition of calpain by leupeptin may cause enhancement or inhibition of cellular functions depending on the nature of the prot... | ['Adenosine Triphosphate', 'Blood Platelets', 'Calcium', 'Collagen', 'Humans', 'In Vitro Techniques', 'Kinetics', 'Leupeptins', 'Oligopeptides', 'Reference Values', 'Signal Transduction', 'Tetradecanoylphorbol Acetate', 'Thrombin', 'Thromboxane B2'] | 2,920,837 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['A11.118.188', 'A15.145.229.188'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D05.750.078.280', 'D12.776.860.300.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['D12.644.4... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cerebrovascular Reactivity Impairment in Preclinical Alzheimer's Disease. | BACKGROUND AND PURPOSE: A substantial overlap exists between declines in cerebral vasoreactivity (CVR) and symptomatic Alzheimer's disease (AD). CVR can be quantified using transcranial Doppler (TCD) measurement of cerebral blood flow velocities (CBFV) in the middle cerebral artery (MCA) with CO2 as a vasodilatory stim... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Brain', 'Breath Holding', 'Cerebrovascular Circulation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Middle Cerebral Artery', 'Pilot Projects', 'Positron-Emission Tomography', 'Ultrasonography, Doppler, Transcranial'] | 30,748,053 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['A08.186.211'], ['G09.772.705.349'], ['G09.330.100.159'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.015.114.228.550'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720'... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A case report of visceral leishmaniasis in Singapore. | Visceral leishmaniasis (Indian kala-azar) caused by infection due to the protozoan Leishmania donovani is endemic in the Indian subcontinent and adjoining regions. Prolonged fever, hepatosplenomegaly, anaemia and pancytopenia, in the appropriate setting, are important clinical markers towards the diagnosis. Diagnosis i... | ['Adult', 'Antiprotozoal Agents', 'Humans', 'Leishmaniasis, Visceral', 'Male', 'Pentamidine', 'Singapore'] | 9,494,684 | [['M01.060.116'], ['D27.505.954.122.250.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.752.300.500.510', 'C01.920.813.510'], ['D02.078.100.700'], ['Z01.252.145.774']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Renewal of electrotonic synapses in teleost retinal horizontal cells. | In teleost retinas, the somata of same-type cone horizontal cells are electrically coupled via extensive gap junctions, as are the axon terminals of same-type cells. This coupling persists throughout the animal's life and is modulated by dopamine and conditions of light- vs. dark-adaptation. Gap junction particle densi... | ['Animals', 'Bass', 'Electrophysiology', 'Intercellular Junctions', 'Microscopy, Electron', 'Retina', 'Synapses'] | 2,229,483 | [['B01.050'], ['B01.050.150.900.493.602.105'], ['H01.158.344.528', 'H01.158.782.236'], ['A11.284.149.165.420'], ['E01.370.350.515.402', 'E05.595.402'], ['A09.371.729'], ['A08.850', 'A11.284.149.165.420.780']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Age structure, environmental fluctuations, and hermaphroditic sex allocation. | This paper studies sex allocation in an age-structured population of hermaphrodites living in a temporally fluctuating environment. The general condition for the evolutionary stable state (ESS) of allocation is derived for density-independent dynamics. This condition is used to determine the effect on the deterministic... | ['Biological Evolution', 'Disorders of Sex Development', 'Models, Genetic', 'Sex Determination Analysis', 'Stochastic Processes', 'Time Factors'] | 2,312,342 | [['G05.045', 'G16.075'], ['C12.706.316', 'C13.351.875.253', 'C16.131.939.316', 'C19.391.119'], ['E05.599.395.397'], ['E01.370.225.996', 'E05.200.996', 'E05.393.285.830'], ['E05.318.740.996', 'G17.830', 'N05.715.360.750.770', 'N06.850.520.830.996'], ['G01.910.857']] | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Sudden hearing loss following non-petrous craniotomy. | We present two patients with known otosclerosis undergoing craniotomy for conditions unrelated to the temporal bone who experienced sudden sensorineural hearing loss. In both patients, the hearing loss was noted immediately post-operatively and there was no subsequent recovery. Sudden hearing loss is a rare complicatio... | ['Anesthetics', 'Causality', 'Cochlear Implantation', 'Craniotomy', 'Ear Ossicles', 'Ear, Inner', 'Ear, Middle', 'Female', 'Hearing Loss, Sensorineural', 'Humans', 'Iatrogenic Disease', 'Intracranial Aneurysm', 'Meningeal Neoplasms', 'Meningioma', 'Middle Aged', 'Neurosurgical Procedures', 'Otosclerosis', 'Postoperativ... | 19,889,544 | [['D27.505.696.277.100', 'D27.505.954.427.210.100'], ['N05.715.350.200', 'N06.850.490.625'], ['E04.580.450.220', 'E04.650.220'], ['E04.525.190'], ['A09.246.397.247'], ['A09.246.300'], ['A09.246.397'], ['C09.218.458.341.887', 'C10.597.751.418.341.887', 'C23.888.592.763.393.341.887'], ['B01.050.150.900.649.313.988.400.11... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Brain transcriptome of the violet-eared waxbill Uraeginthus granatina and recent evolution in the songbird genome. | Songbirds are important models for the study of social behaviour and communication. To complement the recent genome sequencing of the domesticated zebra finch, we sequenced the brain transcriptome of a closely related songbird species, the violet-eared waxbill (Uraeginthus granatina). Both the zebra finch and violet-ea... | ['Animals', 'Brain', 'Evolution, Molecular', 'Genetic Variation', 'Genome', 'Male', 'Phylogeny', 'Songbirds', 'Transcriptome'] | 24,004,662 | [['B01.050'], ['A08.186.211'], ['G05.045.250', 'G16.075.250'], ['G05.365'], ['G05.360.340'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B01.050.150.900.248.620.750'], ['G02.111.873.750', 'G05.297.700.750', 'G05.360.920']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Bone marrow aspirate combined with low-level laser therapy: a new therapeutic approach to enhance bone healing. | This study evaluated the influence of bone marrow aspirate (BMA), low-level laser therapy (LLLT) and their combination on bone healing in surgically created critical-size defects (CSDs) in rat calvaria. 40 rats were divided into four groups: C (control), BMA, LLLT and BMA/LLLT. A 5mmdiameter CSD was created in the calv... | ['Animals', 'Drug Therapy, Combination', 'Immunohistochemistry', 'Low-Level Light Therapy', 'Male', 'Mesenchymal Stem Cell Transplantation', 'Rats', 'Skull', 'Wound Healing'] | 23,474,527 | [['B01.050'], ['E02.319.310'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['E02.594.540', 'E02.774.500'], ['E02.095.147.500.500... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. | Foxp3(+) T-regulatory cells (Tregs) are key to immune homeostasis such that their diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3(+) Tregs express multiple histone/protein deacetylases (HDACs) that regulate chromatin remodeling, gene expression, and protein function. Pan-HDAC inhibi... | ['Anilides', 'Animals', 'Autoimmunity', 'Blotting, Western', 'Colitis', 'Disease Progression', 'Flow Cytometry', 'Forkhead Transcription Factors', 'Gene Targeting', 'Graft Rejection', 'HSP90 Heat-Shock Proteins', 'Histone Deacetylase 6', 'Histone Deacetylase Inhibitors', 'Histone Deacetylases', 'Hydroxamic Acids', 'Imm... | 21,444,725 | [['D02.065.199', 'D02.092.146.113'], ['B01.050'], ['G12.450.192'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C06.405.205.265', 'C06.405.469.158.188'], ['C23.550.291.656'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[In vitro activity of arbekacin against clinical isolates of Staphylococcus species and gram-negative bacilli]. | BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) and some gram-negative bacilli are very prevalent nosocomial pathogens, commonly causing mixed infections, and are often resistant to multiple drugs. Arbekacin is an aminoglycoside used for the treatment of MRSA infections, but is also active against some g... | ['Anti-Bacterial Agents', 'Dibekacin', 'Gram-Negative Bacteria', 'Gram-Negative Bacterial Infections', 'Humans', 'Methicillin Resistance', 'Microbial Sensitivity Tests', 'Staphylococcal Infections', 'Staphylococcus aureus'] | 18,094,591 | [['D27.505.954.122.085'], ['D09.408.051.476.200'], ['B03.440'], ['C01.150.252.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G06.099.225.500.600.525', 'G06.225.347.500.600.525', 'G07.690.773.984.269.347.500.600.525'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['C01.150.252.410.868'], ['B... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of azithromycin on ozone-induced airway neutrophilia and cytokine release. | Exposure of humans to ozone causes increased neutrophils and inflammatory cytokines in airway lining fluid. Recent research shows that macrolide antibiotics may reduce interleukin (IL)-8 production by bronchial epithelial cells and inhibit neutrophil chemotaxis. A double-blind, cross-over study was performed in which 1... | ['Adult', 'Anti-Bacterial Agents', 'Azithromycin', 'Cross-Over Studies', 'Double-Blind Method', 'Female', 'Humans', 'Interleukin-6', 'Interleukin-8', 'Lung', 'Male', 'Neutrophils', 'Ozone', 'Peroxidase', 'Spirometry', 'Sputum'] | 10,853,849 | [['M01.060.116'], ['D27.505.954.122.085'], ['D02.540.576.500.992.050'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.224', 'D12.776.467.374.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Diagnostic markers of acute infections in infants aged 1 week to 3 months: a retrospective cohort study. | OBJECTIVE: History and physical examination do not reliably exclude serious bacterial infections (SBIs) in infants. We examined potential markers of SBI in young febrile infants.DESIGN: We reviewed white cell count (WBC), absolute neutrophil count (ANC), neutrophil to lymphocyte count ratio (NLR) and C reactive protein... | ['Acute Disease', 'Area Under Curve', 'Bacterial Infections', 'Biomarkers', 'C-Reactive Protein', 'Female', 'Fever', 'Humans', 'Infant', 'Infant, Newborn', 'Israel', 'Leukocyte Count', 'Logistic Models', 'Lymphocyte Count', 'Male', 'Neutrophils', 'Predictive Value of Tests', 'ROC Curve', 'Retrospective Studies'] | 29,371,270 | [['C23.550.291.125'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['C01.150.252'], ['D23.101'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['C23.888.119.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['Z01.252.245.5... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Relative impact of amyloid-â, lacunes, and downstream imaging markers on cognitive trajectories. | SEE COHEN DOI101093/AWW183 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Amyloid-â and cerebral small vessel disease are the two major causes of cognitive impairment in the elderly. However, the underlying mechanisms responsible for precisely how amyloid-â and cerebral small vessel disease affect cognitive impairment re... | ['Aged', 'Amyloid beta-Peptides', 'Aniline Compounds', 'Cerebral Cortex', 'Cerebral Small Vessel Diseases', 'Cognitive Dysfunction', 'Executive Function', 'Female', 'Humans', 'Longitudinal Studies', 'Magnetic Resonance Imaging', 'Male', 'Memory Disorders', 'Positron-Emission Tomography', 'Stroke, Lacunar', 'Thiazoles'] | 27,329,772 | [['M01.060.116.100'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['D02.092.146'], ['A08.186.211.200.885.287.500'], ['C10.228.140.300.275', 'C14.907.253.329'], ['F03.615.250.700'], ['F02.463.217'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A slow-light laser radar system with two-dimensional scanning. | We propose a multi-aperture slow-light laser radar with two-dimensional scanning. We demonstrate experimentally that we can use two independent slow-light mechanisms, namely dispersive delay and stimulated Brillouin scattering, to dynamically compensate the group delay mismatch among different apertures, while we use o... | ['Lasers', 'Light', 'Radar'] | 22,297,342 | [['E07.632.490', 'E07.710.520'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['L01.178.847.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of SCH 39166, a novel dopamine D1 receptor antagonist, on [3H]acetylcholine release in rat striatal slices. | SCH 39166 is a novel and selective dopamine D1 receptor antagonist. It has been reported to have potential antipsychotic properties and reduced extrapyramidal side-effect liabilities (EPS). The current studies investigated the pharmacological effects of SCH 39166 on striatal cholinergic function in order to further cha... | ['Acetylcholine', 'Animals', 'Apomorphine', 'Benzazepines', 'Choline', 'Corpus Striatum', 'Dopamine Antagonists', 'Electric Stimulation', 'Haloperidol', 'In Vitro Techniques', 'Male', 'Rats', 'Rats, Inbred Strains', 'Receptors, Dopamine', 'Receptors, Dopamine D1', 'Receptors, Dopamine D2', 'Sulpiride'] | 1,535,318 | [['D02.092.211.111'], ['B01.050'], ['D03.132.098.038.290', 'D03.633.100.531.085.030.290', 'D03.633.400.095.290'], ['D03.633.100.079'], ['D02.033.100.291.211', 'D02.092.063.291.211', 'D02.092.877.883.333', 'D02.675.276.232'], ['A08.186.211.200.885.287.249.487'], ['D27.505.519.625.150.175', 'D27.505.696.577.150.175'], ['... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid decline of OspC borreliacidal antibodies following treatment of patients with early Lyme disease. | We determined whether the levels of OspC borreliacidal antibodies declined following treatment of early Lyme disease and whether the OspC7 peptide enzyme-linked immunosorbent assay (ELISA) could be used as an alternative test for detecting the response. Serum samples were collected from 37 subjects at the onset of illn... | ['Adult', 'Anti-Bacterial Agents', 'Antibodies, Bacterial', 'Antigens, Bacterial', 'Bacterial Outer Membrane Proteins', 'Blood Bactericidal Activity', 'Doxycycline', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Immunoglobulin G', 'Immunoglobulin M', 'Lyme Disease', 'Oligopeptides', 'Time Factors'] | 21,508,161 | [['M01.060.116'], ['D27.505.954.122.085'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D23.050.161'], ['D12.776.097.120', 'D12.776.543.100'], ['G09.188.100', 'G12.450.564.204'], ['D02.455.426.559.847.562.900.200', 'D04.615.562.900.200'], ['E05.478.566.350.170', 'E05.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cancer of the male genital tract in Circumpolar Inuit. | In an international collaboration project we combined cancers of the male genital tract among Inuit identified from routine cancer registry systems in the Circumpolar region (Alaska, Canada and Greenland) and compared incidence rates with rates in Denmark, Connecticut (USA) and Canadian non-Inuit. We observed a low ris... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Alaska', 'Arctic Regions', 'Canada', 'Child', 'Child, Preschool', 'Genital Neoplasms, Male', 'Greenland', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Inuits', 'Male', 'Middle Aged', 'Penile Neoplasms', 'Prostatic Neoplasms', 'Registries', 'Testicular Neoplas... | 8,813,066 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['Z01.107.567.875.580.100'], ['Z01.208'], ['Z01.107.567.176'], ['M01.060.406'], ['M01.060.406.448'], ['C04.588.945.440', 'C12.294.260', 'C12.758.409'], ['Z01.107.567.403', 'Z01.542.816.124.500', 'Z01.639.400']... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Reactivity of 6-halopurine analogs with glutathione as a radiotracer for assessing function of multidrug resistance-associated protein 1. | 6-Bromo-7-[(11)C]methylpurine is reported to react with glutathione via glutathione S-transferases in the brain and to be converted into a substrate for multidrug resistance-associated protein 1 (MRP1), an efflux pump. The compound with a rapid conversion rate allows quantitative assessment of MRP1 function, but this r... | ['Animals', 'Brain', 'Drug Design', 'Glutathione', 'Humans', 'Hydrophobic and Hydrophilic Interactions', 'Isomerism', 'Kinetics', 'Male', 'Mice', 'Multidrug Resistance-Associated Proteins', 'Positron-Emission Tomography', 'Protein Binding', 'Purines', 'Radioactive Tracers', 'Rats'] | 19,921,956 | [['B01.050'], ['A08.186.211'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D12.644.456.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.409'], ['G02.111.570.685', 'G02.607.445'], ['G01.374.661', 'G02.111.490'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.157.530.100.304'... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. | The islet in type 2 diabetes is characterized by a deficit in beta-cell mass, increased beta-cell apoptosis, and impaired insulin secretion. Also, islets in type 2 diabetes often contain deposits of islet amyloid derived from islet amyloid polypeptide (IAPP), a 37-amino acid protein cosecreted with insulin by beta-cell... | ['Aging', 'Amyloid', 'Animals', 'Animals, Genetically Modified', 'Apoptosis', 'Blood Glucose', 'Body Weight', 'Cell Division', 'Diabetes Mellitus, Experimental', 'Diabetes Mellitus, Type 2', 'Disease Models, Animal', 'Humans', 'Insulin', 'Islet Amyloid Polypeptide', 'Islets of Langerhans', 'Osmolar Concentration', 'Rat... | 15,161,755 | [['G07.345.124'], ['D05.500.049', 'D12.776.049'], ['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['G04.146.954.035'], ['D09.947.875.359.448.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evolution of ruminant Sarcocystis (Sporozoa) parasites based on small subunit rDNA sequences. | We present an evolutionary analysis of 13 species of Sarcocystis, including 4 newly sequenced species with ruminants as their intermediate host, based on complete small subunit rDNA sequences. Those species with ruminants as their intermediate host form a well-supported clade, and there are at least two major clades wi... | ['Animals', 'DNA, Ribosomal', 'Evolution, Molecular', 'Genetic Variation', 'Host-Parasite Interactions', 'Molecular Sequence Data', 'Phylogeny', 'RNA, Ribosomal', 'Sarcocystis', 'Species Specificity', 'Statistics as Topic'] | 10,082,608 | [['B01.050'], ['D13.444.308.475'], ['G05.045.250', 'G16.075.250'], ['G05.365'], ['G16.527.200.400'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.735.686'], ['B01.043.075.189.250.750.750'], ['G16.824'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.850.520.830']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Rh(I)-catalyzed ring opening of an IMDAF-derived oxabicyclo cycloadduct as the key step in the synthesis of (+/-)-epi-zephyranthine. | [reaction: see text] A new strategy for epi-zephyranthine has been developed that is based in part on an extraordinarily facile intramolecular Diels-Alder reaction of a 2-imido-substituted furan. By using a Rh(I)-catalyzed ring opening of the resulting oxabicyclic adduct, the cis-diol stereochemistry of epi-zephyranthi... | ['Alkaloids', 'Amaryllidaceae Alkaloids', 'Bridged Bicyclo Compounds, Heterocyclic', 'Catalysis', 'Furans', 'Indoles', 'Phenanthridines', 'Rhodium', 'Stereoisomerism'] | 15,200,317 | [['D03.132'], ['D03.132.052'], ['D03.605.084'], ['G02.130'], ['D03.383.312'], ['D03.633.100.473'], ['D03.633.300.633'], ['D01.268.556.793', 'D01.268.956.781', 'D01.552.544.793'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stabilization of granulocyte-macrophage colony-stimulating factor RNA in a human eosinophil-like cell line requires the AUUUA motifs. | Human eosinophils activated by calcium ionophore produce granulocyte-macrophage colony-stimulating factor (GM-CSF). In T lymphocytes GM-CSF messenger RNA (mRNA) stability is regulated by 3' untranslated region (UTR) adenosine-uridine-rich elements (AREs). We show endogenous GM-CSF mRNA is rapidly induced in an eosinoph... | ['Binding Sites', 'Cell Line', 'Dactinomycin', 'Eosinophils', 'Gene Expression Regulation', 'Granulocyte-Macrophage Colony-Stimulating Factor', 'Humans', 'RNA, Messenger'] | 9,824,539 | [['G02.111.570.120'], ['A11.251.210'], ['D03.633.300.200', 'D04.345.566.252', 'D12.644.641.252'], ['A11.118.637.415.345', 'A11.627.340.345', 'A15.145.229.637.415.345', 'A15.382.490.315.251'], ['G05.308'], ['D12.644.276.374.410.240.375', 'D12.776.395.240.300', 'D12.776.467.374.410.240.375', 'D23.529.374.410.240.375'], [... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pre- and post-operative management of dental implant placement. Part 1: management of post-operative pain. | Although dental implant placements have high success rates and a low incidence of morbidity, post-operative pain and complications with the healing process have been reported. There is little guidance available regarding optimal pre- and post-operative management of dental implant placement. This first paper discusses ... | ['Analgesics', 'Dental Implants', 'Female', 'Humans', 'Male', 'Pain, Postoperative'] | 25,104,691 | [['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['D25.339.312', 'E06.780.346.593', 'E07.695.185', 'J01.637.051.339.312'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.767.700', 'C23.888.592.612.832']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cerebral CT findings in male opioid-dependent patients: stereological, planimetric and linear measurements. | Cerebrospinal fluid (CSF) space enlargement has been demonstrated in substance-related disorders like alcohol and cocaine dependence. Experimental animal studies showed a reduction in shape and size of mesolimbic dopaminergic neurons after chronic morphine administration. Other studies indicated a change of neurofilame... | ['Adult', 'Atrophy', 'Brain', 'Cerebral Cortex', 'Cerebral Ventricles', 'Data Interpretation, Statistical', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Opioid-Related Disorders', 'Tomography, X-Ray Computed'] | 9,849,723 | [['M01.060.116'], ['C23.300.070'], ['A08.186.211'], ['A08.186.211.200.885.287.500'], ['A08.186.211.140'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['C25.775.643.500', 'F03.900.647.500'],... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
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