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Prescription patterns in the elderly population--"new" versus "old" medical card holders. | INTRODUCTION: In July 2001, the GMS Scheme was extended to the whole elderly population aged 70 and over, permitting access to medical care services free of charge. We undertook a study to compare prescribing patterns between those relatively affluent people referred to as "new" over 70s with those relatively deprived ... | ['Aged', 'Databases, Factual', 'Female', 'Health Services for the Aged', 'Humans', 'Ireland', 'Logistic Models', 'Male', 'Pharmaceutical Preparations', 'Social Class'] | 15,532,969 | [['M01.060.116.100'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['N02.421.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.467', 'Z01.639.587'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450... | ['Named Groups [M]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Longstanding traumatic tricuspid regurgitation with severe right ventricular failure. | A very unusual case of traumatic tricuspid regurgitation is reported, with severe symptoms of right ventricular failure, extreme dilatation of the right heart, echocardiographic and angiographic criteria of major tricuspid regurgitation, and severe right ventricular systolic dysfunction. The patient was referred for he... | ['Accidents, Traffic', 'Echocardiography', 'Follow-Up Studies', 'Heart Failure', 'Heart Injuries', 'Heart Valve Prosthesis Implantation', 'Humans', 'Male', 'Middle Aged', 'Tricuspid Valve', 'Tricuspid Valve Insufficiency', 'Ventricular Dysfunction, Right', 'Wounds, Nonpenetrating'] | 9,427,135 | [['N06.850.135.392'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C14.280.434'], ['C26.891.375'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Difference between monoclonal antibodies against the common acute leukemia antigen from two different hybridomas. | Antibodies directed against the common acute lymphoid leukemia antigen (CALLA) were obtained from 2 hybridomas: J5 (Schlossman, mice sensitized with patient ALL cells), and Vil-A1 (Knapp, sensitization with the Reh cell line). The percentage of lymphoid cells reacting with these 2 monoclonal antibodies were compared. A... | ['Adolescent', 'Adult', 'Animals', 'Antibodies, Monoclonal', 'Antigens, Neoplasm', 'Child', 'Child, Preschool', 'Humans', 'Hybridomas', 'Leukemia, Lymphoid', 'Mice', 'Neprilysin'] | 6,230,985 | [['M01.060.057'], ['M01.060.116'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.285'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.353.485', 'A11.251.600.485'], ['C04.557.337.428', 'C15.604.515.... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
PD-L1 expression in small cell neuroendocrine carcinomas. | Small cell lung cancer and extrapulmonary small cell carcinomas are the most aggressive type of neuroendocrine carcinomas. Clinical treatment relies on conventional chemotherapy and radiotherapy; relapses are frequent. The PD-1/PD-L1/PD-L2 pathway is a major target of anti-tumour immunotherapy. Aberrant PD-L1 or PD-L2 ... | ['B7-H1 Antigen', 'Carcinoma, Small Cell', 'Gene Expression Regulation, Neoplastic', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Immunohistochemistry', 'Lung Neoplasms', 'Lymphocytes, Tumor-Infiltrating', 'Macrophages', 'Neoplasm Metastasis', 'Neuroendocrine Tumors', 'Programmed Cell Death 1 Ligand 2 Protein', ... | 25,582,496 | [['D12.776.465.625', 'D12.776.467.150.300', 'D12.776.543.095.300', 'D23.050.301.285.400', 'D23.529.168.300'], ['C04.557.470.200.380'], ['G05.308.370'], ['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Predictive models of eukaryotic transcriptional regulation reveals changes in transcription factor roles and promoter usage between metabolic conditions. | Transcription factors (TF) are central to transcriptional regulation, but they are often studied in relative isolation and without close control of the metabolic state of the cell. Here, we describe genome-wide binding (by ChIP-exo) of 15 yeast TFs in four chemostat conditions that cover a range of metabolic states. We... | ['Basic-Leucine Zipper Transcription Factors', 'Cluster Analysis', 'Eukaryotic Cells', 'Gene Expression Profiling', 'Gene Ontology', 'Models, Genetic', 'Nitrogen', 'Promoter Regions, Genetic', 'Protein Binding', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Transcription Factors'] | 30,976,803 | [['D12.776.260.108', 'D12.776.930.127'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['A11.450'], ['E05.393.332'], ['H01.158.273.343.249.099', 'H01.770.644.145.350.124', 'L01.224.050.375.480.500.500', 'L01.313.500.750.300.550.500.500', 'L01.453.245.945.079.500'], ['E05.599.395.397'], ['D01.268.60... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Quantum of infection of Francisella tularensis tularensis in host-seeking Dermacentor variabilis. | The American dog tick, Dermacentor variabilis, is fundamental to the perpetuation of Francisella tularensis tularensis on Martha's Vineyard, Massachusetts, U.S.A. Although infected ticks are relatively common on the island, human cases deriving from tick bite are rare. It may be that the quantum of bacteria within thes... | ['Animals', 'Arachnid Vectors', 'Dermacentor', 'Feeding Behavior', 'Francisella tularensis', 'Real-Time Polymerase Chain Reaction'] | 20,563,231 | [['B01.050'], ['N06.850.335.188.100.100', 'N06.850.520.203.375.100.100'], ['B01.050.500.131.166.132.832.400.200'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B03.440.400.425.340.590', 'B03.660.250.200.750'], ['E05.393.620.500.706']] | ['Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Unilateral nevoid telangiectasia syndrome. Study of cutaneous estrogen receptors]. | We present four observations of unilateral nevoid telangiectasia syndrome, pointing out its common cervicothoracic distribution and its relation with hyper-estrogenic conditions, both physiological (puberty, pregnancy, use of contraceptive pills), and pathologic (post-alcoholic hepatic cirrhosis). We also comment on it... | ['Adolescent', 'Adult', 'Angiomatosis', 'Diagnosis, Differential', 'Estrogens', 'Female', 'Humans', 'Liver Cirrhosis, Alcoholic', 'Male', 'Middle Aged', 'Pregnancy', 'Pregnancy Complications', 'Receptors, Estrogen', 'Skin Neoplasms', 'Syndrome', 'Telangiectasis'] | 6,397,668 | [['M01.060.057'], ['M01.060.116'], ['C14.907.077'], ['E01.171'], ['D27.505.696.399.472.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.630.380', 'C06.552.645.590', 'C23.550.355.412.380', 'C25.775.100.087.645.550'], ['M01.060.116.630'], ['G08.686.784.769'], ['C13.703'], ['D12.776.826.750.350', 'D12.776... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prevalence of aspirin-exacerbated respiratory disease in patients with asthma in Turkey: a cross-sectional survey. | BACKGROUND: There are no country-based data focused on aspirin (ASA)-exacerbated respiratory disease (AERD) in Turkey.OBJECTIVE: To assess the prevalence of AERD in adult patients with asthma.METHODS: A structured questionnaire was administered via face-to-face interview by a specialist in pulmonology/allergy at seven ... | ['Adult', 'Anti-Inflammatory Agents, Non-Steroidal', 'Aspirin', 'Asthma', 'Asthma, Aspirin-Induced', 'Cross-Sectional Studies', 'Disease Progression', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nasal Polyps', 'Prevalence', 'Prognosis', 'Respiratory Tract Diseases', 'Rhinitis', 'Risk Factors', 'Sinusitis', 'Turkey'] | 21,889,254 | [['M01.060.116'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D02.455.426.559.389.657.410.595.176'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['C08.127.108.054', 'C08.674.095.054', 'C20.543.206.189', 'C20.543.480.149', 'C25.100.468.189'], ['E05.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Exercise Training Attenuates Proinflammatory Cytokines, Oxidative Stress and Modulates Neurotransmitters in the Rostral Ventrolateral Medulla of Salt-Induced Hypertensive Rats. | BACKGROUND/AIMS: Exercise training (ExT) was associated with cardiovascular diseases including hypertension. The rostral ventrolateral medulla (RVLM) is a key region for central control of blood pressure and sympathetic nerve activity. Therefore, this study aimed to investigate the mechanisms within RVLM that can influ... | ['Animals', 'Blood Pressure', 'Cytokines', 'Exercise Therapy', 'Hypertension', 'Kidney', 'Male', 'Medulla Oblongata', 'NADPH Oxidases', 'Neurotransmitter Agents', 'Oxidative Stress', 'Physical Conditioning, Animal', 'Rats, Wistar', 'Sodium Chloride, Dietary', 'Sympathetic Nervous System'] | 30,048,986 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['C14.907.489'], ['A05.810.453'], ['A08.186.211.132.810.591.500'], ['D08.811.682.608.575', 'D12.776.331.894', 'D12.776.543.653'], ['D27.505.519.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Intraoperative hemodynamics of pyrolytic carbon cambered bileaflet valve replacement in animals]. | Pyrolytic carbon cambered bileaflet valve developed by Chengdu University of Technology and Sciences was evaluated for its hemodynamics. The curved surface of the valve leaflet is cylindrical. Under anaesthesia, cardiopulmonary bypass and chemical cardioplegia, a cambered bileaflet valve (i.d. = 16 mm) was replaced at ... | ['Animals', 'Heart', 'Heart Valve Prosthesis', 'Hemodynamics', 'Male', 'Mitral Valve', 'Postoperative Period', 'Sheep'] | 2,591,919 | [['B01.050'], ['A07.541'], ['E07.695.310'], ['G09.330.380'], ['A07.541.510.507'], ['E04.614.750', 'N02.421.585.753.750'], ['B01.050.150.900.649.313.500.380.791']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Apolipoprotein E epsilon 4 allele in association with global cognitive performance and CSF markers in Alzheimer's disease. | To better define the influence of apolipoprotein E (ApoE) epsilon 4 genotype on the cognitive and biochemical features of Alzheimer's disease (AD), cross-sectional analysis of global cognitive measures and cerebrospinal fluid studies gathered on AD subjects at a tertiary care facility between 1986 and 1997 was carried ... | ['Aged', 'Aged, 80 and over', 'Alleles', 'Alzheimer Disease', 'Apolipoprotein E4', 'Apolipoproteins E', 'Cognition Disorders', 'Female', 'Gene Frequency', 'Genetic Markers', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'tau Proteins'] | 9,850,873 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G05.360.340.024.340.030'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D10.532.091.500.750', 'D12.776.070.400.500.750', 'D12.776.521.120.500.750'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['F03.615.250'], ['G05.330'], ['D23... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Simulation fidelity: more than experience and mere repetition? | Our understanding and use of simulation based training has evolved from simply practicing or learning performance in an accurate re-creation of the operating room as first envisaged by anaesthetist simulation pioneers. The efficacy of simulation training has been quantitatively demonstrated in prospective, randomized, ... | ['Clinical Competence', 'Computer Simulation', 'General Surgery', 'Simulation Training', 'User-Computer Interface'] | 24,732,493 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['L01.224.160'], ['H02.403.810.300'], ['I02.903.847'], ['L01.224.900.910']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
Possibility of cellulose-based electro-active paper energy scavenging transducer. | In this paper, a cellulose-based Electro-Active Paper (EAPap) energy scavenging transducer is presented. Cellulose is proven as a smart material, and exhibits piezoelectric effect. Specimens were prepared by coating gold electrodes on both sides of cellulose film. The fabricated specimens were tested by a base excited ... | ['Cellulose', 'Electricity', 'Paper', 'Transducers', 'Vibration'] | 25,942,809 | [['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['G01.358.500.249'], ['J01.637.650'], ['E07.305.812'], ['G01.374.930']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Algorithm for the detection of muscle activation in surface electromyograms during periodic activity. | A simple surface electromyography (EMG) activation detection algorithm was developed for improved numerical definition of initiation and deactivation of muscle activity during periodic motion when maximum voluntary contractions are impractical to obtain. For the encapsulation of activation/ deactivation periods of a si... | ['Algorithms', 'Electromyography', 'Humans', 'Movement', 'Muscle Contraction', 'Muscle, Skeletal', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Signal Processing, Computer-Assisted', 'Skin', 'Wheelchairs'] | 11,874,145 | [['G17.035', 'L01.224.050'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.568', 'G11.427.410'], ['G11.427.494'], ['A02.633.567', 'A10.690.552.500'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Ablation of glutamate receptor GluRä2 in adult Purkinje cells causes multiple innervation of climbing fibers by inducing aberrant invasion to parallel fiber innervation territory. | Glutamate receptor GluRä2 is exclusively expressed in Purkinje cells (PCs) from early development and plays key roles in parallel fiber (PF) synapse formation, elimination of surplus climbing fibers (CFs), long-term depression, motor coordination, and motor learning. To address its role in adulthood, we previously deve... | ['Analysis of Variance', 'Animals', 'Cerebellum', 'Dendrites', 'Electrophysiology', 'Mice', 'Mice, Knockout', 'Motor Skills', 'Nerve Fibers', 'Nerve Net', 'Neuronal Tract-Tracers', 'Purkinje Cells', 'Receptors, AMPA', 'Rotarod Performance Test', 'Statistics, Nonparametric', 'Synapses'] | 21,068,325 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['A08.186.211.132.810.428.200'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['H01.158.344.528', 'H01.158.782.236'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[Cytogenetic study of married couples with recurrent spontaneous abortions]. | A cytogenetic study was carried out in the chromosome set for 202 couples with recurrent spontaneous abortions of unknown genesis. Anomalies in the chromosome set were observed in 2.5% of cases. | ['Abortion, Spontaneous', 'Chromosome Aberrations', 'Chromosome Banding', 'Female', 'Genetic Counseling', 'Humans', 'Male', 'Marriage', 'Pregnancy', 'Recurrence'] | 6,464,193 | [['C13.703.039', 'G08.686.784.769.496.125'], ['C23.550.210', 'G05.365.590.175'], ['E01.370.225.500.385.130', 'E01.370.225.500.620.670.130', 'E01.370.225.750.600.670.130', 'E05.200.500.385.130', 'E05.200.500.620.670.130', 'E05.200.750.600.670.130', 'E05.242.385.130', 'E05.393.285.130'], ['H01.158.273.343.385.500.384', '... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Naturally occurring mucoepidermoid carcinoma in the submandibular salivary gland of two mice. | Mucoepidermoid carcinomas in two mice were investigated histologically, immunohistochemically and ultrastructurally. The neoplastic cells showed divergent differentiation into periodic acid-Schiff-positive mucous cells, keratin-positive squamous cells, and cells with both mucous granules and sheaves of tonofilaments. G... | ['Actins', 'Animals', 'Carcinoma, Mucoepidermoid', 'Female', 'Immunohistochemistry', 'Keratins', 'Mice', 'Mice, Inbred BALB C', 'Microscopy, Electron', 'Rodent Diseases', 'Submandibular Gland Neoplasms'] | 9,573,510 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['C04.557.470.200.025.340', 'C04.557.470.590.340'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Detection of tandem duplications and implications for linkage analysis. | The first demonstration of an autosomal dominant human disease caused by segmental trisomy came in 1991 for Charcot-Marie-Tooth disease type 1A (CMT1A). For this disorder, the segmental trisomy is due to a large tandem duplication of 1.5 Mb of DNA located on chromosome 17p11.2-p12. The search for the CMT1A disease gene... | ['Alleles', 'Charcot-Marie-Tooth Disease', 'Chromosome Mapping', 'Chromosomes, Human, Pair 17', 'Computer Simulation', 'Genes, Dominant', 'Genetic Linkage', 'Genetic Markers', 'Genotype', 'Humans', 'Likelihood Functions', 'Models, Genetic', 'Models, Statistical', 'Multigene Family', 'Pedigree', 'Phenotype'] | 8,198,134 | [['G05.360.340.024.340.030'], ['C10.500.300.200', 'C10.574.500.495.200', 'C10.668.829.800.300.200', 'C16.131.666.300.200', 'C16.320.400.375.200'], ['E05.393.183'], ['A11.284.187.520.300.415.425', 'G05.360.162.520.300.415.425'], ['L01.224.160'], ['G05.360.340.024.340.240', 'G05.420.320'], ['G05.348'], ['D23.101.387', 'G... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
A meta-analysis of six placebo-controlled trials of thiazolidinedione therapy for HIV lipoatrophy. | OBJECTIVE: To determine the impact of thiazolidinediones (TZD) on changes in limb fat mass in HIV-infected individuals, particularly in those not receiving a thymidine analogue.METHODS: Individual patient data from placebo-controlled, randomized trials of rosiglitazone (n = 5) or pioglitazone (n = 1) were combined. Gen... | ['Adult', 'Body Fat Distribution', 'Female', 'HIV', 'HIV Infections', 'Humans', 'Lipodystrophy', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Pioglitazone', 'Rosiglitazone', 'Thiazolidinediones'] | 20,400,410 | [['M01.060.116'], ['E01.370.600.115.100.062', 'G02.111.130.134', 'G03.180.134', 'G07.100.049.134'], ['B04.820.650.589.650.350'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.849.391'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
CYP3A4 active site volume modification by mutagenesis of leucine 211. | The leucine 211 --> phenylalanine (L211F) and leucine 211 --> tyrosine (L211Y) mutant forms of cytochrome P450 3A4 have been generated by site-directed mutagenesis and expressed functionally in Escherichia coli. Substrate binding affinities (S50 values) for testosterone and 7-benzyloxy-4-trifluoromethylcoumarin (BFC) w... | ['Amino Acid Substitution', 'Anti-Anxiety Agents', 'Anti-Bacterial Agents', 'Binding Sites', 'Coumarins', 'Cytochrome P-450 CYP3A', 'Cytochrome P-450 Enzyme System', 'Diazepam', 'Enzyme Activation', 'Enzyme Inhibitors', 'Erythromycin', 'Hydroxylation', 'Kinetics', 'Leucine', 'Mixed Function Oxygenases', 'Mutagenesis, S... | 11,901,100 | [['E05.393.420.601.035', 'G05.558.109'], ['D27.505.696.277.950.015', 'D27.505.954.427.210.950.015', 'D27.505.954.427.700.872.015'], ['D27.505.954.122.085'], ['G02.111.570.120'], ['D03.383.663.283.446', 'D03.633.100.150.446'], ['D08.244.453.860.500', 'D08.811.682.662.582.353', 'D08.811.682.690.708.170.495.500', 'D12.776... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Measuring Burnout Among Psychiatry Clerkship Directors. | OBJECTIVE: The primary purpose of this study was to determine the prevalence of burnout among Psychiatry clerkship directors.METHODS: Psychiatry clerkship directors were solicited via email to complete an electronic version of the Maslach Burnout Inventory-General Survey and the Respondent Information Form.RESULTS: Fif... | ['Burnout, Professional', 'Clinical Clerkship', 'Female', 'Humans', 'Male', 'Middle Aged', 'Physician Executives', 'Physicians', 'Psychiatry', 'Surveys and Questionnaires'] | 28,939,953 | [['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['I02.358.105'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.526.070.700', 'M01.526.485.800', 'N02.360.800'], ['M01.526.485.810', 'N02.360.810'], ['F04.096.544', 'H02.403.690'], ['E05.318.308.980', 'N05.715.360.300.800',... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
MinCD-independent inhibition of cell division by a protein that fuses MalE to the topological specificity factor MinE. | We report that MinE, the topological specificity factor of cell division in Escherichia coli, inhibits septation when fused to the C terminus of the maltose-binding protein MalE. This contrasts with overexpression of MinE alone, which affects growth but has no effect on division. Inhibition by MalE-MinE was minCD indep... | ['ATP-Binding Cassette Transporters', 'Adenosine Triphosphatases', 'Bacterial Proteins', 'Carrier Proteins', 'Cell Cycle Proteins', 'Cell Division', 'Cytoskeletal Proteins', 'Escherichia coli', 'Escherichia coli Proteins', 'Heat-Shock Response', 'Maltose-Binding Proteins', 'Membrane Proteins', 'Monosaccharide Transport... | 9,226,273 | [['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['D08.811.277.040.025'], ['D12.776.097'], ['D12.776.157'], ['D12.776.167'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D12.776.220'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells. | In this report, we demonstrate the sequence-specific suppression of viral expression in T cells chronically infected with human immunodeficiency virus 1 (HIV-1), using antisense phosphorothioate oligodeoxynucleotides. As a target for antisense intervention, we used the HIV-1 gene rev, which is essential for viral repli... | ['Base Sequence', 'Cells, Cultured', 'DNA, Viral', 'Exons', 'Gene Products, rev', 'Genes', 'Genes, Viral', 'HIV-1', 'Humans', 'Kinetics', 'Molecular Sequence Data', 'RNA', 'RNA, Antisense', 'RNA, Messenger', 'T-Lymphocytes', 'Viral Proteins', 'rev Gene Products, Human Immunodeficiency Virus'] | 2,471,199 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251'], ['D13.444.308.568'], ['G05.360.340.024.340.137.232'], ['D12.776.157.725.076', 'D12.776.664.962.186', 'D12.776.964.925.984.385'], ['G05.360.340.024.340'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['B04.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Vocal frequency change reflects different responses to anthropogenic noise in two suboscine tyrant flycatchers. | Anthropogenic noise is prevalent across the globe and can exclude birds from otherwise suitable habitat and negatively influence fitness; however, the mechanisms responsible for species' responses to noise are not always clear. One effect of noise is a reduction in effective acoustic communication through acoustic mask... | ['Acoustic Stimulation', 'Animals', 'Human Activities', 'Humans', 'New Mexico', 'Noise', 'Passeriformes', 'Sound Spectrography', 'Vocalization, Animal'] | 21,123,268 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['B01.050'], ['I03'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.760.560'], ['G01.750.770.776.567', 'G16.500.275.600', 'N06.230.400', 'N06.850.460.610'], ['B01.050.150.900.248.620'], ['E05.855'], ['F01.145.113.055.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
The effects of Spirulina supplementation on metabolic syndrome components, its liver manifestation and related inflammatory markers: A systematic review. | AIMS: The aim of this systematic review was to assess the effects of Spirulina supplementation on metabolic syndrome components, its liver manifestation and related inflammatory markers.METHODS: We searched PubMed and Scopus (up to August 2017) to identify relevant studies. English randomized controlled trials (RCTs) i... | ['Animals', 'Biomarkers', 'Dietary Supplements', 'Humans', 'Inflammation', 'Liver', 'Metabolic Syndrome', 'Nutrition Therapy', 'Randomized Controlled Trials as Topic', 'Spirulina'] | 30,670,232 | [['B01.050'], ['D23.101'], ['G07.203.300.456', 'J02.500.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['A03.620'], ['C18.452.394.968.500.570', 'C18.452.625'], ['E02.642'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.500', 'N06.850.520.450.250.250.365.500'], ['B03.280.697']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Plasma alpha-L-fucosidase: presence of a low activity variant in some normal individuals. | The expression of a variant alpha-L-fucosidase has been determined in both plasma and leukocytes. This variant enzyme is characterized by unusually tow actuvity in plasma, an altered pH activity profile, and increased heat lability. Individuals possessing this low activity variant in plasma have usual levels of alpha-L... | ['Adult', 'Child', 'Chromatography, Gel', 'Disaccharidases', 'Genetic Variation', 'Humans', 'Isoenzymes', 'Leukocytes', 'Molecular Weight', 'alpha-L-Fucosidase'] | 956,698 | [['M01.060.116'], ['M01.060.406'], ['E05.196.181.400.250'], ['D08.811.277.450.329'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['G02.494'], ['D08.811.277.450.050']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[The levels of adenine nucleotides and hypoxanthine in blood of patients on long-term hemodialysis using dialysis fluid containing acetate or bicarbonate]. | Intraerythrocyte adenine nucleotides concentration reflects energy balance of red cells and plays pivotal role in their function. In hemodialysed patients both ATP and ADP concentration in red cells was higher than in controls, p < 0.001 and p < 0.005 respectively. But AMP and hypoxanthine did not differ from control. ... | ['Acetates', 'Adenosine Diphosphate', 'Adenosine Triphosphate', 'Adult', 'Bicarbonates', 'Female', 'Hemodialysis Solutions', 'Humans', 'Hypoxanthine', 'Male', 'Middle Aged', 'Renal Dialysis'] | 9,190,631 | [['D02.241.081.018', 'D10.251.400.045'], ['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['M01.060.116'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['D26.776.708.322.651', 'D27.505.954.578.483.651', '... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Variability of nisin-synthesizing wild strain Lactococcus lactis subsp. lactis 119 under the effect of ultraviolet light]. | To increase the nisin synthesizing activity of the natural strain Lactococcus lactis subsp. lactis 119 isolated from sour milk, UV irradiation in different doses was used followed by isolation of productive clones. The highest mutation effect was observed with the dose of 76,000 erg/mm2, when 11% of the cells increased... | ['Animals', 'Lactococcus lactis', 'Microbial Viability', 'Nisin', 'Ultraviolet Rays'] | 18,318,142 | [['B01.050'], ['B03.353.750.737.500.400', 'B03.510.400.800.500.400', 'B03.510.550.737.500.400'], ['G06.580'], ['D04.345.566.582', 'D12.644.641.582', 'D12.776.097.151.700', 'D12.776.543.695.110.700'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G16.500... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The G60S connexin43 mutant regulates hair growth and hair fiber morphology in a mouse model of human oculodentodigital dysplasia. | Patients expressing mutations in the gene encoding the gap junction protein Cx43 suffer from a disease called oculodentodigital dysplasia (ODDD). Patients with ODDD are often reported to develop hair that is dry, dull, sparse, and slow growing. To evaluate the linkage between Cx43 and hair growth, structure, and follic... | ['Abnormalities, Multiple', 'Animals', 'Cell Proliferation', 'Connexin 43', 'Disease Models, Animal', 'Eye Abnormalities', 'Female', 'Gap Junctions', 'Hair', 'Humans', 'Male', 'Mice', 'Mice, Mutant Strains', 'Microscopy, Electron, Scanning', 'Phenotype', 'Point Mutation', 'Syndactyly', 'Tooth Abnormalities'] | 21,716,323 | [['C16.131.077'], ['B01.050'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.776.543.585.250.200'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C11.250', 'C16.131.384'], ['A11.284.149.165.420.471'], ['A17.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Distal radius: anatomical morphometric gender characteristics. Do anatomical pre-shaped plates pay attention on it? | INTRODUCTION: The purpose of the study was to investigate differences in the osseous structure anatomy of male and female distal radii.METHODS: Morphometric data were obtained of 49 distal human cadaveric radii. An imprint of the distal edge was attained using silicone mass and the palmar cortical angle (PCA) of the la... | ['Aged', 'Aged, 80 and over', 'Body Weights and Measures', 'Bone Plates', 'Cadaver', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prosthesis Design', 'Radius', 'Sex Characteristics'] | 25,388,864 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.600.115.100', 'E05.041.124', 'G07.100.100'], ['E07.695.370.374', 'E07.858.442.660.460.374', 'E07.858.690.725.460.374'], ['C23.550.260.224'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.320.550', 'E07.695.680'], ['A02.835.232.087.09... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Anatomy of the pectoral and forelimb muscles of wildtype and green fluorescent protein-transgenic axolotls and comparison with other tetrapods including humans: a basis for regenerative, evolutionary and developmental studies. | The axolotl Ambystoma mexicanum is one of the most used model organisms in evolutionary, developmental and regenerative studies, particularly because it can reconstitute a fully functional and complete forelimb/hindlimb. Surprisingly, there is no publication that describes all the pectoral and forelimb muscles of this ... | ['Ambystoma mexicanum', 'Animals', 'Animals, Genetically Modified', 'Biological Evolution', 'Dissection', 'Forelimb', 'Green Fluorescent Proteins', 'Humans', 'Muscle, Skeletal', 'Pectoralis Muscles'] | 22,957,800 | [['B01.050.150.900.090.608.080.068.525'], ['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['G05.045', 'G16.075'], ['E01.370.225.998.221', 'E04.221', 'E05.200.998.221'], ['A13.395'], ['D12.776.532.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.567', 'A10.690.552.500'], ['A02.633.567.775']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of the pelvis and posterior part of the vertebral column in the Anura. | The anuran pelvic girdle is unique among all amphibians in that its acetabular portion is located far posterior to the sacrum, lateral to the postsacral (= caudal) vertebral column, which is reduced to a single rod-like element called the urostyle. This situation in the adult is strikingly different not only from that ... | ['Animals', 'Anura', 'Biological Evolution', 'Bufo bufo', 'Embryo, Nonmammalian', 'Life Style', 'Pelvic Bones', 'Spine', 'Xenopus laevis'] | 15,679,868 | [['B01.050'], ['B01.050.150.900.090.180'], ['G05.045', 'G16.075'], ['B01.050.150.900.090.180.210.108'], ['A13.350', 'A16.331'], ['F01.829.458'], ['A02.835.232.043.825'], ['A02.835.232.834'], ['B01.050.150.900.090.180.610.500.562']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early and late complications following laparoscopic adjustable gastric banding. | There is limited U.S. data on short- and long-term complications of laparoscopic adjustable gastric banding (LAGB) as a treatment option for morbid obesity. Hereafter, we present our experience with the first 154 consecutive LAGBs performed at Loyola University Medical Center. Inpatient and outpatient charts were revie... | ['Adolescent', 'Adult', 'Aged', 'Female', 'Gastroplasty', 'Humans', 'Illinois', 'Incidence', 'Laparoscopy', 'Male', 'Middle Aged', 'Postoperative Complications', 'Reoperation', 'Retrospective Studies', 'Statistics, Nonparametric', 'Time Factors', 'Weight Loss'] | 15,011,918 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.650.500.062.750', 'E04.062.750', 'E04.210.485'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.350', 'Z01.107.567.875.510.350'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
How reliable is the morphological diagnosis of penile ulcerations? | Material from 100 consecutive men who presented with penile ulcerations was tested for a variety of microorganisms. Fifty-one patients had microorganisms identified that were considered primary pathogens. The laboratory data were compared with the clinical diagnoses and the diagnostic accuracy and index of suspicion ca... | ['Adolescent', 'Adult', 'Aged', 'Balanitis', 'Candidiasis', 'Chancroid', 'Diagnosis, Differential', 'Gonorrhea', 'Herpes Simplex', 'Humans', 'Male', 'Middle Aged', 'Skin Ulcer', 'Syphilis'] | 594,859 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C12.294.494.136'], ['C01.150.703.160'], ['C01.150.252.400.700.433.308', 'C01.150.252.734.201', 'C01.221.812.281.201', 'C01.778.281.201', 'C12.294.668.281.201', 'C13.351.500.711.281.201'], ['E01.171'], ['C01.150.252.400.625.275', 'C01.150.252.734.401', 'C01.221.8... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
CYFRA 21-1 is not superior to SCC antigen and CEA in head and neck squamous cell cancer. | CYFRA 21-1 was compared to the most reliable tumor markers for squamous cell carcinoma of the head and neck (HNSCC), SCC antigen and CEA. Sera of 163 patients with primary and 40 patients with recurrent HNSCC were examined. 94 patients with non-malignant ENT-diseases served as the control group. To give a specificity o... | ['Antigens, Neoplasm', 'Biomarkers, Tumor', 'Carcinoembryonic Antigen', 'Carcinoma, Squamous Cell', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Keratin-19', 'Keratins', 'Male', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'ROC Curve', 'Sensitivity and Specificity', 'Serpins'] | 8,920,778 | [['D23.050.285'], ['D23.101.140'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D05.750.078.593.450.300.900', 'D12.776.220.475.450.3... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Differential expression of decay-accelerating factor isoforms in the digestive tract of guinea pig. | Decay-accelerating factor (DAF, CD55), one of the membrane-binding regulators of complement activation, prevents host cells from the autologous complement-mediated attack. However, specific localization of DAF in the different layers of the digestive tract has not been defined. Using a crypt isolation procedure, we sep... | ['Animals', 'Blotting, Northern', 'CD55 Antigens', 'Colon', 'DNA Primers', 'Epithelial Cells', 'Gastric Mucosa', 'Guinea Pigs', 'Immunoenzyme Techniques', 'Intestinal Mucosa', 'Intestine, Small', 'Protein Isoforms', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain Reaction'] | 11,853,224 | [['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['D12.776.395.550.448.130', 'D12.776.543.484.500.130', 'D12.776.543.550.418.130'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['A11.436'], ['A03.556.875.875.440', 'A10.615.550.291'], ['B... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Risks of psychiatric disorders and suicide attempts in children and adolescents with type 1 diabetes: a population-based cohort study. | OBJECTIVE: To assess the risk of psychiatric disorders and suicide attempts in children with type 1 diabetes and their healthy siblings.RESEARCH DESIGN AND METHODS: We performed a population-based case-cohort study of individuals born in Sweden between 1973 and 2009. Children with type 1 diabetes (n = 17,122) and their... | ['Adolescent', 'Child', 'Child, Preschool', 'Diabetes Mellitus, Type 1', 'Epidemiologic Methods', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Siblings', 'Suicide, Attempted', 'Sweden'] | 25,650,362 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['E05.318', 'N06.850.520'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F01.829.263.500.490', 'I01.880.853.150.500.505', 'M01.781'], ['F01.145.126.980.875.600', 'I01.880.735.856.600'], ['Z01.54... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Sural nerve pathology in ALS patients: a single-centre experience. | Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease of upper and lower motor neurons. Sensory involvement is thought not to be a feature of ALS. We reviewed 17 cases of sural nerve biopsies performed in a large cohort of ALS patients referred to our centre over a 23-year period. More than two-thir... | ['Adult', 'Aged', 'Amyotrophic Lateral Sclerosis', 'Female', 'Humans', 'Male', 'Middle Aged', 'Peripheral Nervous System Diseases', 'Sural Nerve'] | 22,203,334 | [['M01.060.116'], ['M01.060.116.100'], ['C10.228.854.139', 'C10.574.562.250', 'C10.574.950.050', 'C10.668.467.250', 'C18.452.845.800.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.668.829'], ['A08.800.800.720.450.760.820.820']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Application of crossed assay design in test of drug sensitivity in vitro in combined chemotherapy of liver cancer]. | A cross assay design has been carried out to test the sensitivity of drugs used in combined chemotherapy of liver cancer using human tumor cloning system in vitro. The reductive rate of the tumor clone survival was synthetically compared and statistically analysed according to calculating formula of crossed assay desig... | ['Antineoplastic Combined Chemotherapy Protocols', 'Carcinoma, Hepatocellular', 'Cisplatin', 'Doxorubicin', 'Drug Screening Assays, Antitumor', 'Fluorouracil', 'Humans', 'Liver Neoplasms', 'Mitomycin', 'Podophyllotoxin', 'Tumor Cells, Cultured'] | 8,174,486 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['E01.370.225.500.388', 'E05... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association between preterm delivery and subsequent C-reactive protein: a retrospective cohort study. | OBJECTIVE: We sought to determine whether giving birth preterm is associated with raised maternal C-reactive protein (CRP) in later life and whether the association is specific to indicated or spontaneous delivery.STUDY DESIGN: This was a Scotland-wide retrospective cohort study of 1124 women who had a first pregnancy ... | ['Abortion, Spontaneous', 'Adolescent', 'Adult', 'Aged', 'C-Reactive Protein', 'Cohort Studies', 'Delivery, Obstetric', 'Female', 'Health Surveys', 'Humans', 'Hypertension', 'Inflammation', 'Middle Aged', 'Pre-Eclampsia', 'Pregnancy', 'Premature Birth', 'Prenatal Exposure Delayed Effects', 'Retrospective Studies', 'Ris... | 21,890,096 | [['C13.703.039', 'G08.686.784.769.496.125'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E04.520.252'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.8... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells. | Bradykinin stimulation of inositol polyphosphate production was followed using [3H]inositol-labeled porcine aortic endothelial cells grown in culture. Bradykinin stimulated a significant increase in inositol trisphosphate (IP3) production within 15 s. This increase reached a maximum value of 5-fold above control at 30 ... | ['Animals', 'Aorta', 'Bradykinin', 'Cell Membrane', 'Cells, Cultured', 'Endothelium', 'Glycoproteins', 'Inositol', 'Inositol Phosphates', 'Kinetics', 'Pertussis Toxin', 'Protein Biosynthesis', 'Proteins', 'Saposins', 'Sphingolipid Activator Proteins', 'Sugar Phosphates', 'Swine', 'Virulence Factors, Bordetella'] | 3,771,575 | [['B01.050'], ['A07.015.114.056'], ['D12.644.276.812.169', 'D12.644.400.090', 'D12.644.456.193', 'D12.776.467.812.169', 'D12.776.631.650.090', 'D23.469.050.375.110', 'D23.529.812.169'], ['A11.284.149'], ['A11.251'], ['A10.272.491'], ['D09.400.430', 'D12.776.395'], ['D02.033.800.519', 'D09.853.519'], ['D02.033.800.519.4... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Children's Blood Lead Concentrations from 1988 to 2015 in Mexico City: The Contribution of Lead in Air and Traditional Lead-Glazed Ceramics. | Despite the removal of lead from gasoline in 1997, elevated blood lead levels (BLLs) > 5 µg/dL are still detectable in children living in Mexico City. The use of lead-glazed ceramics may explain these persistent exposure levels. Mexico lacks a national surveillance program for BLL, but temporal trends can be derived fr... | ['Air Pollutants', 'Ceramics', 'Child', 'Child, Preschool', 'Environmental Exposure', 'Female', 'Humans', 'Infant', 'Lead', 'Lead Poisoning', 'Male', 'Mexico', 'Vulnerable Populations'] | 30,274,368 | [['D27.888.284.101'], ['J01.637.153'], ['M01.060.406'], ['M01.060.406.448'], ['N06.850.460.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D01.268.556.435', 'D01.552.544.435'], ['C25.723.522.750'], ['Z01.107.567.589'], ['M01.965']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Urine concentration of nuclear matrix protein 22 for diagnosis of transitional cell carcinoma of bladder. | INTRODUCTION: The aim of this study was to determine the diagnostic value of urine nuclear matrix protein 22 (NMP22) level in detection of transitional cell carcinoma (TCC) of the bladder.MATERIALS AND METHODS: A total of 76 patients with newly-diagnosed or recurrent TCC and 75 controls without urinary tract disorders ... | ['Aged', 'Biomarkers, Tumor', 'Carcinoma, Transitional Cell', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Nuclear Proteins', 'Predictive Value of Tests', 'Reproducibility of Results', 'Urinary Bladder Neoplasms'] | 19,101,898 | [['M01.060.116.100'], ['D23.101.140'], ['C04.557.470.200.430'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.625'], ['D12.776.660'], ['E05.318.370.800.650', 'N05.715.36... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Selection of optimal extraction process for huolisu capsule by orthogonal design]. | OBJECTIVE: To find out the optimal extraction process for Huolisu capsule.METHOD: The extraction process was studied by orthogonal design with yield of the extracted ginsenoside Re and anthraquinone content determined by RP-HPLC as indexes.RESULT: The result showed that the optimal extraction process was 50% alcohol, 8... | ['Analysis of Variance', 'Anthraquinones', 'Capsules', 'Chromatography, High Pressure Liquid', 'Drugs, Chinese Herbal', 'Ginsenosides', 'Plants, Medicinal', 'Technology, Pharmaceutical'] | 14,692,327 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D02.455.426.559.847.117.159', 'D02.806.100', 'D04.615.117.159'], ['D26.255.150'], ['E05.196.181.400.300'], ['D20.215.784.500.350', 'D26.335'], ['D02.455.849.919.277', 'D09.408.782.300'], ['B01.650.560'], ['E05.916', 'J01.897.836']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Enlargement of a Modular System-Synthesis and Characterization of an s | The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-closo-dodecaboran... | ['Boron', 'Boron Compounds', 'Boron Neutron Capture Therapy', 'Carboxylic Acids', 'Drug Delivery Systems', 'Esters', 'Glycine', 'Humans', 'Hydrophobic and Hydrophilic Interactions', 'Molecular Structure', 'Neoplasms', 'Sulfhydryl Compounds', 'Triazines'] | 31,509,949 | [['D01.268.513.500'], ['D01.132', 'D02.203'], ['E02.815.722.500.100'], ['D02.241'], ['E02.319.300'], ['D02.241.400'], ['D12.125.481'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.409'], ['G02.111.570', 'G02.466'], ['C04'], ['D02.886.489'], ['D03.383.931']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ultrastructural localization of LH-RH-immunoreactive synapses in the hamster accessory olfactory bulb. | Electron microscopic immunocytochemistry was used to localize luteinizing hormone-releasing (LH-RH) immunoreactivity within the male golden hamster accessory olfactory bulb. Two LH-RH-immunoreactive fiber populations were identified in the accessory olfactory bulb. A superficial system of immunoreactive axons was local... | ['Animals', 'Cricetinae', 'Gonadotropin-Releasing Hormone', 'Histocytochemistry', 'Immunologic Techniques', 'Male', 'Mesocricetus', 'Nerve Fibers', 'Olfactory Bulb', 'Rabbits', 'Synapses'] | 6,751,468 | [['B01.050'], ['B01.050.150.900.649.313.992.635.075.250'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405.740.320'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Air ambulance tasking: mechanism of injury, telephone interrogation or ambulance crew assessment? | OBJECTIVE: The identification of serious injury is critical to the tasking of air ambulances. London's Air Ambulance (LAA) is dispatched by a flight paramedic based on mechanism of injury (MOI), paramedical interrogation of caller (INT) or land ambulance crew request (REQ).This study aimed to demonstrate which of the d... | ['Air Ambulances', 'Humans', 'London', 'Remote Consultation', 'Retrospective Studies', 'Triage', 'Wounds and Injuries'] | 25,527,473 | [['J01.937.285.100.100', 'N02.421.297.879.100.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.433.553', 'Z01.542.363.300.553'], ['L01.178.847.652.550', 'N04.452.758.849.550', 'N04.590.374.800.550'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.... | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Mechanomyogram amplitude correlates with human gastrocnemius medialis muscle and tendon stiffness both before and after acute passive stretching. | The study aimed to assess the level of correlation between muscle-tendon unit (MTU) stiffness and mechanomyogram (MMG) signal amplitude of the human gastrocnemius medialis muscle, both before and after acute passive stretching. The passive torque (Tpass), electrically evoked peak torque (pT) and myotendinous junction d... | ['Adult', 'Ankle Joint', 'Electromyography', 'Humans', 'Male', 'Muscle Stretching Exercises', 'Muscle, Skeletal', 'Range of Motion, Articular', 'Tendons', 'Young Adult'] | 24,951,499 | [['M01.060.116'], ['A02.835.583.378.062'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.169.063.500.387.750', 'E02.779.483.750', 'E02.831.535.483.750', 'G11.427.410.698.277.249', 'I03.350.249'], ['A02.633.567', 'A10.690.552.500'], ['E01.370.600.700', 'G11.427.760'],... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Distinct cytokine patterns may regulate the severity of neonatal asphyxia-an observational study. | BACKGROUND: Neuroinflammation and a systemic inflammatory reaction are important features of perinatal asphyxia. Neuroinflammation may have dual aspects being a hindrance, but also a significant help in the recovery of the CNS. We aimed to assess intracellular cytokine levels of T-lymphocytes and plasma cytokine levels... | ['Asphyxia Neonatorum', 'Cytokines', 'Female', 'Humans', 'Infant, Newborn', 'Male'] | 29,233,180 | [['C16.614.092'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520']] | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Histopathology of the arachnoid granulations and brain in HIV-associated cryptococcal meningitis: correlation with cerebrospinal fluid pressure. | OBJECTIVE: To investigate the histopathology of the arachnoid granulations in patients with HIV-associated cryptococcal meningitis and correlate the findings with clinical data, in particular cerebrospinal fluid (CSF) opening pressure.DESIGN: Case series.METHODS: Postmortems were requested on patients dying during init... | ['AIDS-Related Opportunistic Infections', 'Adult', 'Arachnoid', 'CD4 Lymphocyte Count', 'Cerebrospinal Fluid Pressure', 'Diagnosis', 'Female', 'HIV Infections', 'Humans', 'Intracranial Hypertension', 'Male', 'Meningitis, Cryptococcal'] | 19,952,714 | [['C01.221.250.875.100', 'C01.597.050', 'C01.610.684.050', 'C01.925.597.050', 'C01.925.782.815.616.400.100', 'C20.673.480.100'], ['M01.060.116'], ['A08.186.566.166'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Interleukin-1beta inhibits a tetraethylammonium-induced synaptic potentiation in the rat dentate gyrus in vitro. | The effect of the pro-inflammatory cytokine, interleukin-1beta on an NMDA receptor-independent form of synaptic plasticity brought about by the application of the K+ channel blocker tetraethylammonium, was examined in the rat dentate gyrus in vitro. Field excitatory postsynaptic potentials (EPSPs) were recorded from th... | ['Animals', 'Dentate Gyrus', 'Enzyme Inhibitors', 'Excitatory Postsynaptic Potentials', 'Humans', 'Imidazoles', 'In Vitro Techniques', 'Interleukin-1', 'Long-Term Potentiation', 'Male', 'N-Methylaspartate', 'Potassium Channel Blockers', 'Pyridines', 'Rats', 'Rats, Wistar', 'Tetraethylammonium', 'Time Factors'] | 10,422,760 | [['B01.050'], ['A08.186.211.180.405.200', 'A08.186.211.200.885.287.500.345.200'], ['D27.505.519.389'], ['G04.580.887.249', 'G07.265.675.887.249', 'G07.265.880.750.199', 'G11.561.570.918.249', 'G11.561.830.750.199'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.308'], ['E05.481'], ['D12.644.276.374.465... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Facing a Second Wave from a Regional View: Spatial Patterns of COVID-19 as a Key Determinant for Public Health and Geoprevention Plans. | Several studies on spatial patterns of COVID-19 show huge differences depending on the country or region under study, although there is some agreement that socioeconomic factors affect these phenomena. The aim of this paper is to increase the knowledge of the socio-spatial behavior of coronavirus and implementing a geo... | ['Betacoronavirus', 'COVID-19', 'Coronavirus Infections', 'Geographic Mapping', 'Geography, Medical', 'Humans', 'Pandemics', 'Pneumonia, Viral', 'Public Health', 'SARS-CoV-2', 'Spain'] | 33,207,598 | [['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['C01.925.782.600.550.200'], ['E05.318.389', 'E05.318.740.933.249', 'N05.715.360.750.746.249', 'N06.850.520.830.933.249'], ['H01.277.50... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Fatal systemic phaeohyphomycosis caused by Ochroconis gallopavum in a dog (Canis familaris). | A 5-year-old Shetland Sheepdog was presented with a history of weakness, ataxia, anemia, thrombocytopenia, and occasional seizures. The dog had been treated for 6 months with prednisone for inflammatory bowel disease. A positive titer for Ehrlichia canis was detected 6 months before referral. The initial physical exami... | ['Animals', 'Ascomycota', 'Dog Diseases', 'Dogs', 'Fatal Outcome', 'Female', 'Liver', 'Mycoses'] | 17,099,156 | [['B01.050'], ['B01.300.107'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['A03.620'], ['C01.150.703']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A palaeoparasitological analysis of rodent coprolites from the Cueva Huenul 1 archaeological site in Patagonia (Argentina). | The aim of the present study was to examine the parasite fauna present in rodent coprolites collected from Cueva Huenul 1 (CH1), northern Neuqu?n (Patagonia, Argentina), an archaeological site that provides stratified sequences of archaeological and palaeontological remains dating from the Late Pleistocene/Early Holoce... | ['Animals', 'Argentina', 'Feces', 'Fossils', 'Paleopathology', 'Rodentia'] | 22,850,950 | [['B01.050'], ['Z01.107.757.077'], ['A12.459'], ['I01.076.368.584.311'], ['I01.076.368.584.709'], ['B01.050.150.900.649.313.992']] | ['Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Impaired intestinal barrier function in a mouse model of hyperuricemia. | Previous studies have demonstrated the effects of hyperuricemia on the damage to target organs, including the kidneys, joints and the heart. However, it is unclear whether hyperuricemia results in damage to the intestines. The aim of the present study was to investigate intestinal barrier dysfunction in a mouse model o... | ['Animals', 'Disease Models, Animal', 'Hyperuricemia', 'Interleukin-6', 'Intestinal Mucosa', 'Mice', 'Mice, Knockout', 'Occludin', 'Permeability', 'Tight Junctions', 'Tumor Necrosis Factor-alpha', 'Urate Oxidase', 'Uric Acid', 'Zonula Occludens-1 Protein'] | 31,432,190 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.449'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.529.374.465.224'], ['A03.556.124.369', 'A10.615.550.444'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500.550.455',... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Recurrent urticaria as a rare manifestation of familial Mediterranean fever. | Familial Mediterranean fever (FMF) is a genetic disorder characterized by acute episodes of fever with some combination of severe abdominal pain, pleurisy, arthritis, and skin rash. The case of a patient with recurrent urticaria referred for study of drug allergy is presented. After allergy had been ruled out, the urti... | ['Adult', 'Familial Mediterranean Fever', 'Female', 'Humans', 'Recurrence', 'Urticaria'] | 12,109,534 | [['M01.060.116'], ['C16.320.382.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.291.937'], ['C17.800.862.945', 'C20.543.480.904']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Loss of cannabinoid receptor binding and messenger RNA levels and cannabinoid agonist-stimulated [35S]guanylyl-5'O-(thio)-triphosphate binding in the basal ganglia of aged rats. | Recent reports have demonstrated that cannabinoid receptor binding decreases in several neurodegenerative diseases related to extrapyramidal function. However, there is little evidence with regard to potential changes of these receptors during senescence. The present study was designed to determine the possible existen... | ['Aging', 'Animals', 'Autoradiography', 'Basal Ganglia', 'Benzoxazines', 'Cannabinoids', "Guanosine 5'-O-(3-Thiotriphosphate)", 'In Situ Hybridization', 'Male', 'Morpholines', 'Naphthalenes', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Cannabinoid', 'Receptors, Drug'] | 9,578,396 | [['G07.345.124'], ['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['A08.186.211.200.885.287.249'], ['D03.383.533.249', 'D03.633.100.209'], ['D02.455.849.090'], ['D02.886.765.380', 'D13.695.667.454.504.380', 'D13.695.827.426.504.380', 'D13.695.900.380'], ['E01.370.225.500.620.670.325', 'E01.370.2... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The safety, effectiveness and concentrations of adjusted lopinavir/ritonavir in HIV-infected adults on rifampicin-based antitubercular therapy. | OBJECTIVE: Rifampicin co-administration dramatically reduces plasma lopinavir concentrations. Studies in healthy volunteers and HIV-infected patients showed that doubling the dose of lopinavir/ritonavir (LPV/r) or adding additional ritonavir offsets this interaction. However, high rates of hepatotoxicity were observed ... | ['Adult', 'Anti-HIV Agents', 'Antitubercular Agents', 'Coinfection', 'Drug Interactions', 'Female', 'HIV Infections', 'Humans', 'Lopinavir', 'Male', 'Middle Aged', 'Rifampin', 'Ritonavir', 'Tuberculosis'] | 22,412,856 | [['M01.060.116'], ['D27.505.954.122.388.077.088'], ['D27.505.954.122.085.255'], ['C01.218'], ['G07.690.773.968'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.742.698.553'], ['M01.06... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Chronic corticosteroid administration causes mitochondrial dysfunction in skeletal muscle. | Corticosteroid myopathy is a major clinical problem in patients undergoing chronic corticosteroid treatment and shows insidious and progressive muscle atrophy in proximal limbs. Although several mechanisms underlying the pathophysiology of muscle injury have been postulated, precise pathogenesis is still not clear. We ... | ["8-Hydroxy-2'-Deoxyguanosine", 'Adrenal Cortex Hormones', 'Case-Control Studies', 'DNA Damage', 'Deoxyguanosine', 'Dose-Response Relationship, Drug', 'Electron Transport Complex I', 'Electron Transport Complex II', 'Electron Transport Complex III', 'Exercise Test', 'Female', 'Humans', 'Lactic Acid', 'Male', 'Middle Ag... | 12,195,445 | [['D03.633.100.759.590.454.240.500', 'D13.570.230.360.500', 'D13.570.583.454.240.500'], ['D06.472.040'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G05.200'], ['D03.633.100.759.590.454.240', 'D13.570.230.360', 'D13.570.583.454.240'], ['G07.690.773.875', 'G07.690.936.500'], ['D05.50... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bronchospasm and cough as adverse reactions to the ACE inhibitors captopril, enalapril and lisinopril. A controlled retrospective cohort study. | 1. We report a controlled retrospective cohort study of respiratory adverse reactions to ACE inhibitors. Bronchospasm and cough occurred at a higher rate in patients treated with ACE inhibitors, no links with sex, past history of bronchospasm, drug type or dose were found. 2. Cohorts of 1013 patients on angiotensin con... | ['Aged', 'Bronchial Spasm', 'Captopril', 'Chi-Square Distribution', 'Cohort Studies', 'Computer Simulation', 'Cough', 'Enalapril', 'Female', 'Humans', 'Hypolipidemic Agents', 'Lisinopril', 'Male', 'Middle Aged', 'Prevalence', 'Retrospective Studies', 'Sex Factors', 'Surveys and Questionnaires'] | 7,619,667 | [['M01.060.116.100'], ['C08.127.321'], ['D12.125.072.401.623.270'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['L01.224.160'], ['C08.618.248', 'C23.888.852.293'], ['D12.644.456.345.360'], [... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Polarity in gene araB of the l-Arabinose operon in Escherichia coli B/r. | A series of mutations are described which map in the araB gene of the l-arabinose operon and exert a polar effect on gene araA, the structural gene for the l-arabinose isomerase. Ten of the 20 araB point mutants examined exhibited absolute polarity and may represent insertions of genetic material into the araB gene. Th... | ['Arabinose', 'Culture Media', 'Escherichia coli', 'Genes', 'Methods', 'Molecular Biology', 'Mutagens', 'Mutation', 'Operon', 'Transduction, Genetic'] | 4,901,356 | [['D09.947.875.627.166'], ['D27.720.470.305', 'E07.206'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.340.024.340'], ['E05.581'], ['H01.158.201.636', 'H01.158.273.343.595', 'H01.181.122.650'], ['D27.888.569.468'], ['G05.365.590'], ['G05.360.340.024.686', 'G05.360.340.358.207.500'], ['E05.393.350.8... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification and chromosome assignment of a human gene encoding a novel phosphatidylinositol-3 kinase. | We identified a novel phosphatidylinositol (PI) 3-kinase by screening human brain cDNA libraries with probes designed from the conserved kinase-domain sequence. Analysis of cDNAs indicated that two different forms of transcripts are present: one is the full-length form composed of 1,044 amino acid residues and the othe... | ['Animals', 'Blotting, Northern', 'Brain', 'Brain Chemistry', 'Chromosome Mapping', 'Chromosomes, Human, Pair 1', 'Cricetinae', 'Gene Library', 'Humans', 'Hybrid Cells', 'In Situ Hybridization, Fluorescence', 'Mice', 'Phosphatidylinositol 3-Kinases', 'Polymerase Chain Reaction', 'RNA, Messenger', 'Tissue Distribution',... | 9,455,486 | [['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['A08.186.211'], ['G02.111.150', 'G03.185'], ['E05.393.183'], ['A11.284.187.520.300.235.240', 'G05.360.162.520.300.235.240'], ['B01.050.150.900.649.313.992.635.075.250'], ['G05.360.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.600'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mass spectrometric determination of tris(1,3-dichloro-2-propyl)-phosphate (TDCP) using NCI-technique. | A number of different products suspected to contain flame retardants were analysed. TDCP was found in 11 out of 104 samples. It was most common in polyurethane products such as sound absorbing materials and liners for cars and buses. To get an integrated picture of TDCP exposure the contents of vacuum cleaner bags from... | ['Electrochemistry', 'Flame Retardants', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Organophosphorus Compounds'] | 3,596,894 | [['H01.181.529.307'], ['D27.720.361'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.705']] | ['Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Anoxic block of GABAergic IPSPs. | In rat hippocampal slices GABAergic IPSPs are very rapidly suppressed by anoxia (in less than 2 min). Both early (GABAA) and late (GABAB) components are affected. After reoxygenation, the IPSPs recover, but only slowly and not always completely. Iontophoretic applications of GABA or baclofen indicated no major depressi... | ['Action Potentials', 'Animals', 'Baclofen', 'Electric Conductivity', 'Hippocampus', 'Kinetics', 'Oxygen', 'Rats', 'Rats, Inbred Strains', 'Synapses', 'gamma-Aminobutyric Acid'] | 1,780,029 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['D02.241.081.114.500.350.100'], ['G01.358.500.249.277'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['G01.374.661', 'G02.111.490'], ['D01.268.185.550', 'D01.362.670'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.52... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Developing a dermatological photodiagnosis system by optical image analyses and in vivo study. | Dermatological photodynamic therapy (DPDT) involves using systematic photosensitizers in combination with light irradiation treatment to eliminate cancer cells. Therefore, a noninvasive fluorescence photodiagnosis system is critical in DPDT for diagnosing target tissues and demarcating the margin of normal tissues. Thi... | ['Animals', 'Cell Line, Tumor', 'Dermoscopy', 'Equipment Design', 'Equipment Failure Analysis', 'Fluorescent Dyes', 'Lighting', 'Melanoma', 'Mice', 'Mice, Nude', 'Microscopy, Fluorescence', 'Photography', 'Porphyrins', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Skin Neoplasms'] | 27,318,114 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['E01.370.350.515.277.250', 'E05.595.185.250'], ['E05.320'], ['E05.325.192'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['N06.230.150.410'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['B01.050.150.900.649.313.992.635.505.500'],... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemia. | Tyrosine kinase inhibitors (TKIs) directed against the Bcr-Abl kinase have revolutionized the treatment of chronic myelogenous leukemia (CML). Relatively little is known regarding the effects of these agents on the kidney. Clinically, there have been a handful of reports associating imatinib with acute renal failure. P... | ['Benzamides', 'Dasatinib', 'Drug Resistance, Neoplasm', 'Female', 'Fusion Proteins, bcr-abl', 'Humans', 'Imatinib Mesylate', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Middle Aged', 'Piperazines', 'Protein Kinase Inhibitors', 'Pyrimidines', 'Renal Dialysis', 'Renal Insufficiency', 'Thiazoles'] | 18,835,038 | [['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['D02.886.675.184', 'D03.383.129.708.198', 'D03.383.742.148'], ['G07.690.773.984.395'], ['D08.811.913.696.620.682.725.500.500', 'D12.776.602.500.500.100', 'D12.776.624.664.500.100', 'D12.776.624.664.700.171.500'], ['B01.050.150.900.649.313.988.400.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Defect-Type-Dependent Near-Infrared-Driven Photocatalytic Bacterial Inactivation by Defective Bi2 | Defect engineering is crucial in tailoring photocatalytic efficiency, but it suffers from uncertainty in determining the vacancy type and in which type of the vacancy can better promote the photocatalytic efficiency. In this study, Bi2 S3 nanorods with bismuth or sulfur vacancies were synthesized to investigate their d... | ['Bacteria', 'Bismuth', 'Catalysis', 'Escherichia coli', 'Infrared Rays', 'Microscopy, Electron, Transmission', 'Nanotubes', 'Photochemical Processes', 'Spectrophotometry, Ultraviolet', 'Spectroscopy, Near-Infrared', 'Sulfides', 'X-Ray Diffraction'] | 30,488,560 | [['B03'], ['D01.268.271.245', 'D01.268.556.100', 'D01.496.749.305.245', 'D01.552.544.100'], ['G02.130'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G01.358.500.505.650.552', 'G01.590.540.552', 'G01.750.250.650.552', 'G01.750.770.578.552', 'G16.500.275.063.725.525.400', 'G16.500.750.775.525.400', 'N06.230... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells. | Urate is produced as the major end product of purine metabolism. In the last decade, the incidence of hyperuricemia increased markedly, and similar trends in the epidemiology of metabolic syndrome have been observed. Hyperuricemia is associated with renal disease, and recent studies have reported that mild hyperuricemi... | ['Animals', 'Blotting, Western', 'Cell Line', 'Disease Models, Animal', 'Epithelial Cells', 'Extracellular Matrix Proteins', 'Fibronectins', 'Fibrosis', 'Fluorescent Antibody Technique', 'Hyperuricemia', 'Kidney Tubules', 'Male', 'Mice', 'Mice, Inbred C57BL', 'NF-kappa B', 'Organic Anion Transporters', 'Probenecid', 'P... | 20,484,295 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.436'], ['D12.776.860.300'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['C23.550.355... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Induction of colony-stimulating activity in mice by injection of liposomes containing lipophilic muramyl peptide derivatives. | Colony-stimulating factor (CSF) activity induction by lipophilic derivatives of three muramyl peptides, glyceryl dipalmitate-MDP derivatives, was studied in vivo and in vitro and compared to the activity of the same compounds incorporated within freeze-dried liposomes. Two lipophilic derivatives (MDP-GDP and MDPGBe-GDP... | ['Acetylmuramyl-Alanyl-Isoglutamine', 'Animals', 'Cells, Cultured', 'Colony-Stimulating Factors', 'Female', 'Liposomes', 'Mice', 'Mice, Inbred DBA', 'Mice, Inbred Strains', 'Reference Values', 'Spleen', 'Structure-Activity Relationship'] | 2,783,556 | [['D09.067.550.050', 'D09.811.522.050', 'D12.644.233.050'], ['B01.050'], ['A11.251'], ['D12.644.276.374.410.240', 'D12.776.395.240', 'D12.776.467.374.410.240', 'D23.529.374.410.240'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Impact of smoking status on outcomes after concomitant aortic valve replacement and coronary artery bypass graft surgery. | BACKGROUND: There is a paucity of data on the impact of smoking status on outcomes after concomitant aortic valve replacement and coronary artery bypass graft (AVR-CABG) surgery.METHODS: Data obtained prospectively between June 2001 and December 2009 by the Australian and New Zealand Society of Cardiac and Thoracic Sur... | ['Aged', 'Aged, 80 and over', 'Aortic Valve', 'Australia', 'Chi-Square Distribution', 'Coronary Artery Bypass', 'Coronary Artery Disease', 'Female', 'Heart Valve Diseases', 'Heart Valve Prosthesis Implantation', 'Humans', 'Incidence', 'Kaplan-Meier Estimate', 'Logistic Models', 'Male', 'Middle Aged', 'Odds Ratio', 'Pos... | 24,163,261 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.541.510.110'], ['Z01.639.100', 'Z01.678.100.373'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14... | ['Named Groups [M]', 'Anatomy [A]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Feeding a polyunsaturated fatty acid diet prevents the age-associated decline in glucose uptake observed in rats fed a saturated diet. | The ability of the intestine to adapt to changes in environmental stimuli may be compromised with aging. Young animals fed saturated fatty acids (SFA) versus polyunsaturated fatty acids (PUFA) have an increased intestinal uptake of glucose. The objectives of this study were to determine (1) the effects of age on glucos... | ['Aging', 'Animals', 'Body Weight', 'Dietary Fats, Unsaturated', 'Fatty Acids', 'Gene Expression', 'Glucose', 'Ileum', 'Jejunum', 'Male', 'Membrane Glycoproteins', 'Monosaccharide Transport Proteins', 'RNA, Messenger', 'Rats', 'Rats, Inbred F344', 'Sodium-Glucose Transporter 1', 'Sodium-Potassium-Exchanging ATPase'] | 12,735,904 | [['G07.345.124'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D10.212.302.380', 'G07.203.300.375.400', 'J02.500.375.400'], ['D10.251'], ['G05.297'], ['D09.947.875.359.448'], ['A03.556.124.684.249', 'A03.556.249.124'], ['A03.556.124.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Mutations and polymorphisms in genes affecting hemostasis proteins and homocysteine metabolism in children with arterial ischemic stroke. | BACKGROUND: The pathogenesis of thrombosis in childhood seems to be multifactorial implicating genetic and environmental factors.AIM: To compare the distributions of mutations/polymorphisms in genes affecting hemostasis (factor V Leiden - FVL, FV H1298R-FVR2, FII 20210A, b-Fib 455G>A, FXIII V34L, PAI-1 4G, HPA-1b) or h... | ['Alleles', 'Brain Ischemia', 'Child, Preschool', 'DNA', 'Factor V', 'Female', 'Genotype', 'Hemostasis', 'Homocysteine', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Mutation', 'Odds Ratio', 'Polymorphism, Genetic', 'Risk Factors', 'Stroke'] | 16,567,932 | [['G05.360.340.024.340.030'], ['C10.228.140.300.150', 'C14.907.253.092'], ['M01.060.406.448'], ['D13.444.308'], ['D12.776.124.125.300', 'D12.776.811.272', 'D23.119.300'], ['G05.380'], ['G09.188.390'], ['D02.886.030.498', 'D12.125.166.498'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. | Social isolation (SI) rearing, a model of early life stress, results in profound behavioral alterations, including increased anxiety-like behavior, impaired sensorimotor gating and increased self-administration of addictive substances. These changes are accompanied by alterations in mesolimbic dopamine function, such a... | ['Age Factors', 'Animals', 'Anxiety', 'Dopamine', 'Dopamine Plasma Membrane Transport Proteins', 'Exocytosis', 'Nucleus Accumbens', 'Rats', 'Rats, Long-Evans', 'Receptors, Dopamine D2', 'Signal Transduction', 'Social Isolation'] | 23,294,165 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['F01.470.132'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D12.776.157.530.450.625.124', 'D12.776.157.530.562.374.500.500', 'D12.776.157.530.937.500', 'D12.776.543.585.450.625.124', 'D12.776.543.585.562.374.500.500', 'D12.7... | ['Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Comparison of adipose stem cells sources from various locations of rat body for their application for seeding on polymer scaffolds. | Adipose tissue yields adult adipose stem cells (ASCs) in large quantities via less-invasive methods. These cells are of interest owing to their modulating properties and paracrine activities, which can be harnessed in regenerative medicine. Many studies on the use of rat fat tissue in an autologous animal model have be... | ['Adipose Tissue', 'Adult Stem Cells', 'Alkaline Phosphatase', 'Animals', 'Biocompatible Materials', 'Cell Proliferation', 'Kinetics', 'Male', 'Osteogenesis', 'Polyesters', 'Rats', 'Tissue Scaffolds'] | 30,686,126 | [['A10.165.114'], ['A11.872.040'], ['D08.811.277.352.650.035'], ['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['G04.161.750', 'G07.345.249.410.750'], ['G01.374.661', 'G02.111.490'], ['G07.345.500.325.377.625.050.500.729', 'G11.427.578.050.500.729'], ['D05.750.728', 'D25.720.728', 'J01.637.051.720.728'... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Chemical, physical, and sensory properties of dairy products enriched with conjugated linoleic acid. | Recent studies have illustrated the effects of cis-9,trans-11 conjugated linoleic acid (CLA) on human health. Ruminant-derived meat, milk and dairy products are the predominant sources of cis-9,trans-11 CLA in the human diet. This study evaluated the processing properties, texture, storage characteristics, and organole... | ['Animals', 'Butter', 'Cattle', 'Cheese', 'Chemical Phenomena', 'Chemistry, Physical', 'Dairy Products', 'Diet', 'Fats', 'Fatty Acids', 'Female', 'Fish Oils', 'Food Handling', 'Food Preservation', 'Food, Fortified', 'Hot Temperature', 'Lactation', 'Linoleic Acids, Conjugated', 'Milk', 'Milk Proteins', 'Plant Oils', 'Se... | 16,027,207 | [['B01.050'], ['D10.212.302.199', 'G07.203.300.350.100', 'G07.203.300.375.200', 'J02.500.350.100', 'J02.500.375.200'], ['B01.050.150.900.649.313.500.380.271'], ['G07.203.200.500.444', 'G07.203.300.350.300.444', 'J02.350.500.444', 'J02.500.350.300.444'], ['G02'], ['H01.181.529'], ['G07.203.300.350', 'J02.500.350'], ['G0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Orientation selectivity in luminance and color vision assessed using 2-d band-pass filtered spatial noise. | We evaluated orientation discrimination in color and luminance vision using an external noise paradigm. Stimuli were spatiotemporal patches of 2D orientation noise isolating the achromatic, red-green and blue-yellow mechanisms, and matched in multiples of contrast detection threshold. We found a monotonic increase of o... | ['Color Perception', 'Contrast Sensitivity', 'Discrimination, Psychological', 'Humans', 'Light', 'Models, Neurological', 'Orientation', 'Pattern Recognition, Visual', 'Photic Stimulation', 'Sensory Thresholds'] | 15,639,495 | [['F02.463.593.932.217'], ['E01.370.380.850.950.500', 'F02.463.593.778.435.110', 'F02.463.593.932.281', 'F02.463.593.932.901.500', 'G14.940.500'], ['F02.463.593.257'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.599.395.642'], ['F0... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Monitoring of mycophenolate acid in serum or plasma using LC tandem mass spectrometry. | Therapeutic drug management of patients receiving mycophenolic mofetil or mycophenolate sodium using mycophenolic acid (MPA) concentrations is controversial. Considered to be less toxic compared to many of the other drugs used in immunosuppression regimens, MPA is not tolerated by all patients. For these patients, moni... | ['Chromatography, Liquid', 'Glucuronides', 'Humans', 'Immunosuppressive Agents', 'Mycophenolic Acid', 'Reproducibility of Results', 'Tandem Mass Spectrometry'] | 20,077,090 | [['E05.196.181.400'], ['D02.241.081.844.915.162.500', 'D02.241.152.811.162.750', 'D02.241.511.902.915.162.750', 'D09.811.922.162.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['D02.241.081.193.678', 'D10.251.618'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Giant haemangioma of the thigh (Kasabach-Merritt syndrome): resection with temporary clamping of the common iliac artery. | A giant haemangioma of the thigh in a 9-month-old infant girl with the Kasabach-Merritt syndrome was operated upon with temporary clamping of the common iliac artery after previous attempts at treatment with external compression, prednisone and radiotherapy had failed. Secondary lymphoedema of the leg and foot appeared... | ['Anemia, Hemolytic', 'Constriction', 'Female', 'Hemangioma', 'Humans', 'Iliac Artery', 'Infant', 'Lymphedema', 'Postoperative Complications', 'Purpura, Thrombocytopenic', 'Syndrome', 'Thigh'] | 4,040,413 | [['C15.378.071.141'], ['E05.225'], ['C04.557.645.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.114.444'], ['M01.060.703'], ['C15.604.496'], ['C23.550.767'], ['C15.378.100.802.687', 'C15.378.140.855.925.750', 'C20.841', 'C23.550.414.950.687', 'C23.888.885.687.687'], ['C23.550.288.500'], ['A01.378.610... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Increased intrahepatic apoptosis but reduced immune activation in HIV-HBV co-infected patients with advanced immunosuppression. | OBJECTIVE: to determine if intrahepatic immune activation is increased in HIV-hepatitis B virus (HBV) co-infected patients compared to HBV mono-infected patients and whether this reduced following HBV-active antiretroviral therapy (ART) in HIV-HBV co-infected patients.DESIGN: : Case-control observational study.METHODS:... | ['AIDS-Related Opportunistic Infections', 'Adult', 'Antiretroviral Therapy, Highly Active', 'Apoptosis', 'DNA, Viral', 'Female', 'HIV Infections', 'HIV-1', 'Hepatitis B, Chronic', 'Humans', 'Immunohistochemistry', 'Immunosuppression', 'Killer Cells, Natural', 'Liver', 'Male', 'Polymerase Chain Reaction', 'Viral Load'] | 21,076,271 | [['C01.221.250.875.100', 'C01.597.050', 'C01.610.684.050', 'C01.925.597.050', 'C01.925.782.815.616.400.100', 'C20.673.480.100'], ['M01.060.116'], ['E02.319.310.075'], ['G04.146.954.035'], ['D13.444.308.568'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C2... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Cesarean plus anoxia at birth induces hyperresponsiveness to locomotor activity by dopamine D2 agonist. | Transient global anoxia after Cesarean birth in rats may produce alterations in the subcortical DA function and related behaviors. The reports only tested the behavioral changes induced by a general DA agonist, such as amphetamine or apomorphine, in adult rats. Here we investigated the role of perinatal anoxia on the l... | ['Animals', 'Autoradiography', 'Birth Injuries', 'Brain', 'Cesarean Section', 'Dopamine', 'Dopamine Agonists', 'Dose-Response Relationship, Drug', 'Female', 'Hypoxia', 'Motor Activity', 'Pregnancy', 'Quinpirole', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Dopamine D1', 'Receptors, Dopamine D2'] | 16,206,184 | [['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['C16.614.131', 'C26.141'], ['A08.186.211'], ['E04.520.252.500'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D27.505.519.625.150.151', 'D27.505.696.577.150.151'], ['G07.690.773.875', 'G07.690.936.500'], ['... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Selective and non-selective cyclooxygenase inhibitors delay stress fracture healing in the rat ulna. | Anti-inflammatory drugs are widely used to manage pain associated with stress fractures (SFxs), but little is known about their effects on healing of those injuries. We hypothesized that selective and non-selective anti-inflammatory treatments would retard the healing of SFx in the rat ulna. SFxs were created by cyclic... | ['Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Bone Remodeling', 'Bone Resorption', 'Complement C5a', 'Cyclooxygenase 2 Inhibitors', 'Fracture Healing', 'Fractures, Bone', 'Fractures, Stress', 'Furans', 'Ibuprofen', 'Osteogenesis', 'Peptides, Cyclic', 'Rats', 'Rats, Wistar', 'Ulna'] | 22,847,634 | [['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['G11.427.213', 'G16.762.150'], ['C05.116.264', 'G11.427.213.150'], ['D12.776.124.486.274.024.270', 'D12.776.124.486.274.450.250'], ['D27.505.519.389.310.500', 'D27.505.696.663.850.014.040.500.500.500', 'D27.505.954.158.030... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessing the impact of fungicide enostroburin application on bacterial community in wheat phyllosphere. | Fungicides have been used extensively for controlling fungal pathogens of plants. However, little is known regarding the effects that fungicides upon the indigenous bacterial communities within the plant phyllosphere. The aims of this study were to assess the impact of fungicide enostroburin upon bacterial communities ... | ['Base Sequence', 'DNA, Bacterial', 'Electrophoresis, Gel, Pulsed-Field', 'Fungicides, Industrial', 'Gammaproteobacteria', 'Molecular Sequence Data', 'Phylogeny', 'Plant Leaves', 'Polymerase Chain Reaction', 'RNA, Ribosomal, 16S', 'Sequence Alignment', 'Triticum'] | 20,397,397 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.212'], ['E05.196.401.220', 'E05.301.300.220'], ['D27.720.031.700.288', 'D27.888.723.288'], ['B03.660.250'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['A18.024.812'], ['E05.393.620.500'], ['D13.444.735.686.670'], ['E05.393.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Real-time conflict-based Bayesian Tobit models for safety evaluation of signalized intersections. | The safety of signalized intersections has traditionally been evaluated at an aggregate level by relating historical collision records for several years to the annual tra?c volume and the geometric characteristics of the intersection. This is a reactive and macroscopic approach that gives little insight into how import... | ['Accidents, Traffic', 'Automobile Driving', 'Bayes Theorem', 'Canada', 'Computer Systems', 'Deceleration', 'Environment Design', 'Humans', 'Models, Statistical', 'Safety Management'] | 32,623,321 | [['N06.850.135.392'], ['I03.125'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['Z01.107.567.176'], ['L01.224.230'], ['G01.482.107.373'], ['I01.283', 'I01.880.709.359', 'N06.230.145'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750... | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Gd-complexes of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs). | We report the synthesis of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H(2)O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R(1) relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a. | ['Animals', 'Contrast Media', 'Coordination Complexes', 'Ferrous Compounds', 'Gadolinium', 'Humans', 'Kinetics', 'Macrocyclic Compounds', 'Magnetic Resonance Imaging', 'Metallocenes', 'Pentetic Acid', 'Rats', 'Serum Albumin', 'Thermodynamics'] | 20,886,175 | [['B01.050'], ['D27.505.259.500', 'D27.720.259'], ['D01.234', 'D02.257'], ['D01.490.200'], ['D01.268.558.362.484', 'D01.552.550.399.484'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D04.345'], ['E01.370.350.825.500'], ['D02.691.657'], ['D02.092.782.590', 'D02.241.081.018.639'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of halothane on ganglionic discharges. | The effects of halothane on ganglionic transmission were studied by recording extracellular potentials from the postganglionic nerve of the isolated hamster stellate ganglion. Halothane, at concentrations greater than 0.1 mM, decreased the potentials evoked by preganglionic stimuli at 0.2 Hz. Halothane also blocked dis... | ['(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride', 'Acetylcholine', 'Action Potentials', 'Animals', 'Cricetinae', 'Depression, Chemical', 'Dimethylphenylpiperazinium Iodide', 'Drug Interactions', 'Electric Stimulation', 'Halothane', 'In Vitro Techniques', 'Parasympatholytics', 'Receptors, Nicotini... | 65,467 | [['D02.092.877.674.033', 'D02.455.326.397.325', 'D02.675.276.210'], ['D02.092.211.111'], ['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['B01.050.150.900.649.313.992.635.075.250'], ['G07.690.773.750'], ['D03.383.606.390'], ['G07.690.773.968'], ['E05.723.402'], ['D02.455.526.340'], ['E05.481'], ['D2... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of Heme Pocket Water in Allosteric Regulation of Ligand Reactivity in Human Hemoglobin. | Water molecules can enter the heme pockets of unliganded myoglobins and hemoglobins, hydrogen bond with the distal histidine, and introduce steric barriers to ligand binding. The spectrokinetics of photodissociated CO complexes of human hemoglobin and its isolated á and â chains were analyzed for the effect of heme hyd... | ['Allosteric Regulation', 'Heme', 'Hemoglobins', 'Humans', 'Ligands', 'Models, Molecular', 'Molecular Dynamics Simulation', 'Photolysis', 'Protein Structure, Quaternary', 'Water', 'alpha-Globins', 'beta-Globins'] | 27,355,904 | [['G02.111.044'], ['D03.383.129.578.840.500.640.587', 'D03.633.400.909.500.640.587', 'D04.345.783.500.640.587', 'D23.767.727.640.587'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.480'], ['E05.599.595'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.5... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Is genetically related macrophage factor (GRF) a soluble immune response (Ir) gene product? | The possibility that the antigen-presenting "macrophages" interacting with helper cells either directly or via the intermediary action of a soluble factor consisting of Ia antigen and a fragment of immunogen, termed GRG (genetically related factor), are a site of Ir gene action was investigated by using the synthetic p... | ['Animals', 'Dinitrobenzenes', 'Dose-Response Relationship, Immunologic', 'Genes, MHC Class II', 'Macrophages', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred CBA', 'Peptides', 'Protein Biosynthesis', 'Solubility', 'T-Lymphocytes'] | 109,518 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Patellar tendon enthesis abnormalities and their association with knee pain and structural abnormalities in older adults. | OBJECTIVE: To describe associations between presence of patellar tendon enthesis (PTE) abnormalities and symptoms, structural abnormalities, and total knee replacement (TKR) in older adult cohort.METHODS: PTE abnormalities (presence of abnormal bone signal and/or bone erosion), were measured on T2-weighted magnetic res... | ['Aged', 'Aged, 80 and over', 'Arthralgia', 'Cross-Sectional Studies', 'Female', 'Humans', 'Knee Joint', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Osteoarthritis, Knee', 'Patellar Ligament', 'Prospective Studies'] | 30,529,466 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C05.550.091', 'C23.888.592.612.094', 'F02.830.816.444.350', 'G11.561.790.444.350'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['E01.370.350.825.500'], ['M01.060.116... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Early detection of risk factors for seclusion and restraint: a prospective study. | AIM: The study aims to examine the predictive power of static and dynamic risk factors assessed at admission to an acute psychiatric ward and to develop a prediction model evaluating the risk of seclusion and restraint.METHODS: Over 20 months, data on demographic and clinical characteristics, psychosocial functioning, ... | ['Adolescent', 'Adult', 'Cooperative Behavior', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Middle Aged', 'Patient Isolation', 'Prospective Studies', 'Psychiatric Department, Hospital', 'Psychiatric Status Rating Scales', 'ROC Curve', 'Restraint, Physical', 'Risk Factors', 'Sensitivity and Specificity'] | 22,277,018 | [['M01.060.057'], ['M01.060.116'], ['F01.145.813.115'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['M01.060.116.630'], ['E02.770', 'N06.850.780.200.450.650'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['N02.278.216.500.968.641', 'N04.452.442.452.422.641']... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Low postseroconversion CD4 count and rapid decrease of CD4 density identify HIV+ fast progressors. | CD4 expression in HIV replication is paradoxical: HIV entry requires high cell-surface CD4 densities, but replication requires CD4 down-modulation. However, is CD4 density in HIV+ patients affected over time? Do changes in CD4 density correlate with disease progression? Here, we examined the role of CD4 density for HIV... | ['Bayes Theorem', 'CD4 Lymphocyte Count', 'Disease Progression', 'HIV', 'HIV Seropositivity', 'Humans', 'Models, Immunological', 'Retrospective Studies'] | 20,715,931 | [['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.500.150'], ['C23.550.291... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Use of alternative medicine among Norwegian hospitalized cancer patients]. | A national multi-centre study was performed to investigate the prevalent use of alternative medicine, or non-proven therapies, among Norwegian cancer patients. Of 911 patients invited to take part in the study 642 were included in the final analysis. Among the 630 assessable patients, 20% had been or were current users... | ['Adult', 'Aged', 'Complementary Therapies', 'Female', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Norway', 'Surveys and Questionnaires'] | 9,265,305 | [['M01.060.116'], ['M01.060.116.100'], ['E02.190'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['Z01.542.816.374'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Distinctions in variability of motor output between learning disabled and normal children. | This study measured the differences in motor output between groups of 8- and 10-yr.-old learning disabled and normal boys. Variability of motor output was investigated by having children learn an alternating tapping task to a criterion of a specified number of taps per minute and then having them transfer to more diffi... | ['Attention', 'Child', 'Humans', 'Learning Disabilities', 'Male', 'Motor Skills', 'Transfer, Psychology'] | 6,664,754 | [['F02.830.104.214'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.150.550', 'C23.888.592.604.150.550', 'F03.625.562'], ['F02.808.260'], ['F02.463.425.910']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Extended duration of vertical position might impair bone metabolism. | Bone-remodelling is markedly influenced by vectors of gravitational forces. Sleep-deprivation, common during military training, involves a change in the normal balance between horizontal and vertical forces enacting on the skeleton. Stress fractures are likewise prevalent among army recruits. In order to investigate th... | ['Adolescent', 'Biomarkers', 'Bone Density', 'Bone Resorption', 'Bone and Bones', 'Calcium', 'Fasting', 'Humans', 'Hydroxyproline', 'Male', 'Phosphorus', 'Posture', 'Sleep', 'Sleep Deprivation', 'Stress, Mechanical', 'Supine Position', 'Time Factors', 'Wakefulness'] | 7,957,496 | [['M01.060.057'], ['D23.101'], ['G11.427.100'], ['C05.116.264', 'G11.427.213.150'], ['A02.835.232', 'A10.165.265'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.072.401.623.478'], ['D0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A comparison of chemotherapy and radiotherapy as adjuvant treatment to surgery for esophageal carcinoma. Japanese Esophageal Oncology Group. | A cooperative, prospective randomized study to compare radiotherapy (50 Gy) or 2 courses of combination chemotherapy consisting of cisplatin (50 mg/m2) and vindesine (3 mg/m2) following curative resection was performed in 258 patients at 9 institutions between August 1985 and August 1987. In the two groups, no differen... | ['Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Chemotherapy, Adjuvant', 'Cisplatin', 'Combined Modality Therapy', 'Esophageal Neoplasms', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Metastasis', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Prospective Studies', 'Radiotherapy Dosage', 'Surviv... | 8,325,071 | [['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E02.186.170', 'E02.319.170'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E02.186'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
MCMI-II diagnosis of borderline personality disorder: base rates versus prototypic items. | The Millon Clinical Multiaxial Inventory-II (MCMI-II) profiles of 26 psychiatric inpatients diagnosed as having borderline personality disorders were compared with profiles of 42 patients with no personality disorders. The borderline group scored significantly higher on the following scales: Disclosure (X), Debasement ... | ['Adult', 'Borderline Personality Disorder', 'Female', 'Hospitalization', 'Hospitals, General', 'Humans', 'Male', 'Mental Disorders', 'Middle Aged', 'Personality Assessment', 'Personality Inventory', 'Psychometrics'] | 1,545,335 | [['M01.060.116'], ['F03.675.100'], ['E02.760.400', 'N02.421.585.400'], ['N02.278.421.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['M01.060.116.630'], ['F04.513'], ['F04.711.647.513'], ['F04.711.780']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Guided self-organization and cortical plate formation in human brain organoids. | Three-dimensional cell culture models have either relied on the self-organizing properties of mammalian cells or used bioengineered constructs to arrange cells in an organ-like configuration. While self-organizing organoids excel at recapitulating early developmental events, bioengineered constructs reproducibly genera... | ['Batch Cell Culture Techniques', 'Cells, Cultured', 'Guided Tissue Regeneration', 'Humans', 'Neural Stem Cells', 'Neurogenesis', 'Organ Culture Techniques', 'Organoids', 'Prosencephalon', 'Tissue Engineering'] | 28,562,594 | [['E05.481.500.249.124'], ['A11.251'], ['E04.680.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.872.653'], ['G04.152.912', 'G07.345.500.325.377.687', 'G08.686.784.170.450.500', 'G11.561.620'], ['E05.481.500.484'], ['A10.802'], ['A08.186.211.200'], ['E05.481.500.311.500', 'J01.293.069.249.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Delay in diagnostic workup and treatment of esophageal cancer. | INTRODUCTION: Esophageal cancer should preferably be detected and treated at an early stage, but this may be prohibited by late onset of symptoms and delays in referral, diagnostic workup, and treatment. The aim of this study was to investigate the impact of these delays on outcome in patients with esophageal cancer.ME... | ['Adult', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Biopsy, Needle', 'Cohort Studies', 'Delayed Diagnosis', 'Esophageal Neoplasms', 'Esophagectomy', 'Esophagoscopy', 'Female', 'Hospital Mortality', 'Humans', 'Kaplan-Meier Estimate', 'Length of Stay', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Probability',... | 20,012,379 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Research funder required research partnerships: a qualitative inquiry. | BACKGROUND: Researchers and funding agencies are increasingly showing interest in the application of research findings and focusing attention on engagement of knowledge-users in the research process as a means of increasing the uptake of research findings. The expectation is that research findings derived from these re... | ['Attitude of Health Personnel', 'Health Services Research', 'Humans', 'Interprofessional Relations', 'Male', 'Qualitative Research', 'Research Personnel', 'Research Support as Topic'] | 25,430,813 | [['F01.100.050', 'N05.300.100'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['H01.770.644.241.850'], ['M01.526.839'], ['N03.219.483.645']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Bilayer thickness in unilamellar extruded 1,2-dimyristoleoyl and 1,2-dierucoyl phosphatidylcholine vesicles: SANS contrast variation study of cholesterol effect. | Small-angle neutron scattering on extruded unilamellar vesicles in water was used to study bilayer thickness when cholesterol (CHOL) was added at 44.4 mol% to 1,2-dimyristoleoylphosphatidylcholine (diC14:1PC) and 1,2-dierucoylphosphatidylcholine (diC22:1PC) bilayers. Using the (1)H(2)O/(2)H(2)O contrast variation and t... | ['Cholesterol', 'Dimyristoylphosphatidylcholine', 'Lipid Bilayers', 'Macromolecular Substances', 'Models, Chemical', 'Neutron Diffraction', 'Phosphatidylcholines', 'Surface Properties', 'Water'] | 15,465,298 | [['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D10.570.755.375.760.400.800.200'], ['D10.570.510', 'J01.637.087.500.510'], ['D05'], ['E05.599.495'], ['E05.196.309.555', 'E05.196.822.650', 'G01.867.650', 'G02.551'], ['D10.570.755.375.760.400.800'], ['G02.860'], ['D01.045.250.875', 'D01.248.... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cloning and sequencing of parafusin, a calcium-dependent exocytosis-related phosphoglycoprotein. | A cDNA for parafusin, an evolutionarily conserved phosphoglycoprotein involved in exocytosis, has been cloned and sequenced from a unicellular eukaryote, Paramecium tetraurelia. A Paramecium cDNA library was screened with an oligonucleotide probe synthesized to an internal amino acid sequence of isolated parafusin. The... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Binding Sites', 'Calcium', 'Cloning, Molecular', 'DNA Primers', 'Exocytosis', 'Gene Library', 'Humans', 'Molecular Sequence Data', 'Oligonucleotide Probes', 'Open Reading Frames', 'Paramecium tetraurelia', 'Phosphoglucomutase', 'Phosphoproteins', 'Polymerase Chain Re... | 7,937,900 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E05.393.220'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G04.468'], ['G05.360.325'], ['B01.050.150.900.64... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
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