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Feasability and safety of transfer from racemic methadone to (R)-methadone in primary care: clinical results from an open study. | Methadone is a proven first-line treatment in opioid dependence but few studies have addressed the efficacy of different isoforms of methadone or the transfer from one form to the other. This was a 4-week open study to examine the feasibility and safety of transfer from racemic methadone to (R)-methadone in primary car... | ['Adult', 'Feasibility Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Methadone', 'Narcotics', 'Opioid-Related Disorders', 'Patient Compliance', 'Primary Health Care', 'Prospective Studies', 'Stereoisomerism', 'Substance Withdrawal Syndrome'] | 19,629,858 | [['M01.060.116'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.522.675'], ['D27.505.696.277.600', 'D27.505.696.663.850.014.760', 'D27.505... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. | BACKGROUND AND AIMS: Hepatic bile acid homeostasis is regulated by negative feedback inhibition of genes involved in the uptake and synthesis of bile acids. Bile acids down-regulate the rate-limiting gene for bile acid synthesis, cholesterol 7alpha-hydroxylase (cyp7a), via bile acid receptor (fxr) activation of an inhi... | ['Animals', 'Bacterial Proteins', 'Bile Acids and Salts', 'Carcinoma, Hepatocellular', 'Carrier Proteins', 'Cytochrome c Group', 'Humans', 'Liver Neoplasms', 'Male', 'Membrane Transport Proteins', 'Organic Anion Transporters, Sodium-Dependent', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Cytoplasmic and Nuclear', 'Symp... | 11,438,503 | [['B01.050'], ['D12.776.097'], ['D04.210.500.105'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['D12.776.157'], ['D08.244.286', 'D12.776.422.220.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['D12.776.157.530', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Involvement of 5-HT2A receptors in the serotonin (5-HT) syndrome caused by excessive 5-HT efflux in rat brain. | Previous studies have demonstrated that serotonin (5-HT) syndromes, particularly for the malignant cases, can be alleviated by ice water mists, cooling blankets and many other external cooling measures. In this study, we tested the hypothesis that external cooling measures reduce the responsivity of 5-HT(2A) receptors ... | ['5-Hydroxytryptophan', 'Animals', 'Body Temperature', 'Brain', 'Clorgyline', 'Hypothermia, Induced', 'Ketanserin', 'Male', 'Microdialysis', 'Monoamine Oxidase Inhibitors', 'Rats', 'Rats, Sprague-Dawley', 'Receptor, Serotonin, 5-HT2A', 'Serotonin', 'Serotonin 5-HT2 Receptor Antagonists', 'Serotonin Syndrome'] | 20,456,331 | [['D12.125.072.050.850.479'], ['B01.050'], ['E01.370.600.875.374', 'G07.110'], ['A08.186.211'], ['D02.092.831.180'], ['E02.258.750'], ['D03.383.621.365', 'D03.633.100.786.830.333'], ['E05.196.353.500'], ['D27.505.519.389.616'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dependency of intraocular pressure elevation and glaucomatous changes in DBA/2J and DBA/2J-Rj mice. | PURPOSE: In this study parameters relevant for glaucoma in DBA/2J (D2J) mice were compared with those in age-matched DBA/2J-Rj (D2Rj) mice, to challenge the postulated role of D2J mice as a model for secondary high-tension glaucoma.METHODS: Genotyping for three known short nucleotide polymorphisms (SNPs) in the Tyrp1 g... | ['Amino Acid Substitution', 'Animals', 'Anterior Eye Segment', 'Axons', 'Disease Progression', 'Exfoliation Syndrome', 'Eye Proteins', 'Fluorescent Antibody Technique, Indirect', 'Genotype', 'Glaucoma, Angle-Closure', 'Intraocular Pressure', 'Membrane Glycoproteins', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'O... | 18,235,006 | [['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['A09.371.060'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['C23.550.291.656'], ['C11.941.375.285'], ['D12.776.306'], ['E01.370.225.500.607.512.240.310', 'E01.370.225.750.551.512.240.310', 'E05.200.500.607.512.240.310', 'E05.200.750.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose. | Feeding and blood glucose responses to local injection of nanoliter volumes of 5-thio-D-glucose (5TG), a potent antimetabolic glucose analogue, were studied at 142 hindbrain and 61 hypothalamic cannula sites. A site was considered positive if 5TG elicited at least 1.5 g more food intake or a hyperglycemic response at l... | ['Animals', 'Antimetabolites', 'Blood Glucose', 'Brain Mapping', 'Chemoreceptor Cells', 'Energy Intake', 'Feeding Behavior', 'Female', 'Glucose', 'Hypothalamus', 'Male', 'Microinjections', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Cell Surface', 'Rhombencephalon'] | 10,677,609 | [['B01.050'], ['D27.505.519.186', 'D27.888.569.042'], ['D09.947.875.359.448.500'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.675.650.915.500', 'A08.800.950.500', 'A11.671.650.915.500'], ['G07.203.650.240.340'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['D09.947.875.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Drug abuse in schizophrenia: comparison of patients who began drug abuse before their first admission with those who began abusing drugs after their first admission. | The relationship between the onset of drug abuse and onset of illness (first hospitalisation) and its correlates were examined in 42 hospitalised schizophrenics identified as drug abusers. 60% of the patients began drug use before their first hospitalisation. No differences on sociodemographic or clinical parameters be... | ['Adult', 'Comorbidity', 'Diagnosis, Dual (Psychiatry)', 'Female', 'Follow-Up Studies', 'Humans', 'Israel', 'Male', 'Middle Aged', 'Patient Admission', 'Patient Compliance', 'Patient Readmission', 'Schizophrenia', 'Schizophrenic Psychology', 'Substance-Related Disorders'] | 7,947,416 | [['M01.060.116'], ['N05.715.350.225', 'N06.850.490.687'], ['E01.190'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.375'], ['M01.060.116.630'], ['E02.760.400.600', 'N02.421.585.400.600'], ['F01.100.150.750.5... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Intestinal bleeding from a caliber-persistent submucosal artery in the ileum. | A 15-year-old boy developed massive intestinal bleeding. The initial mesenteric angiography and ileocolectomy failed to reveal the bleeding site. A repeat mesenteric angiography performed when bleeding recurred showed active bleeding from an ileal branch of the mesenteric artery. Histologically, the lesion proved to be... | ['Adolescent', 'Angiography', 'Gastrointestinal Hemorrhage', 'Humans', 'Ileal Diseases', 'Intestinal Mucosa', 'Male'] | 3,876,366 | [['M01.060.057'], ['E01.370.350.700.060', 'E01.370.370.050'], ['C06.405.227', 'C23.550.414.788'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.420'], ['A03.556.124.369', 'A10.615.550.444']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Flow-dependent arteriolar dilation in normotensive rats fed low- or high-salt diets. | Ingestion of a high-salt diet has previously been shown to suppress the endogenous influence of nitric oxide (NO) on arteriolar tone in hypertension-resistant, salt-resistant Dahl (SR/Jr) rats. Because luminal blood flow can be an important stimulus for endothelial NO release, this study was undertaken to determine whe... | ['Acetylcholine', 'Animals', 'Arachidonic Acid', 'Arginine', 'Arterioles', 'Blood Pressure', 'Diet, Sodium-Restricted', 'Male', 'Meclofenamic Acid', 'Nitric Oxide Synthase', 'Nitroprusside', 'Rats', 'Rats, Inbred Strains', 'Reference Values', 'Regional Blood Flow', 'Sodium Chloride, Dietary', 'Time Factors', 'Vasodilat... | 7,485,574 | [['D02.092.211.111'], ['B01.050'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['A07.015.114.060', 'A07.015.461.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E02.642.249.290', 'G07.203.650.240.290'], ['D02.241.223.100.050.400.200.500', 'D02.4... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pancreatic polypeptide is increased in patients with advanced malignant disease. | BACKGROUND: Augmented secretion of pancreatic polypeptide (PP) has been demonstrated in patients with severe systemic diseases or endocrine tumors. The aim of this study was to evaluate PP and autonomic neuropathy in patients with advanced malignant disease.MATERIALS AND METHODS: Basal PP assessments and five cardiovas... | ['Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Blood Pressure', 'Female', 'Heart Rate', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Pancreatic Polypeptide', 'Vagus Nerve'] | 15,330,207 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.0... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Kidney involvement in a patient affected by placental site trophoblastic tumor. | We report a 42-year-old woman who presents a few days after a spontaneous incomplete abortion at the ninth week of pregnancy with hypertension and nephrotic syndrome. Curettage findings and increased values for the â subunit of human chorionic gonadotrophin were suspicious for a trophoblastic disease. A uterine placent... | ['Abortion, Spontaneous', 'Adult', 'Biopsy', 'Diagnosis, Differential', 'Female', 'Follow-Up Studies', 'Glomerulonephritis', 'Humans', 'Hysterectomy', 'Kidney Glomerulus', 'Microscopy, Electron', 'Pregnancy', 'Thrombotic Microangiopathies', 'Trophoblastic Tumor, Placental Site', 'Uterine Neoplasms'] | 21,257,242 | [['C13.703.039', 'G08.686.784.769.496.125'], ['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E01.171'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C12.777.4... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Percutaneous injection of autologous, culture-expanded mesenchymal stem cells into carpometacarpal hand joints: a case series with an untreated comparison group. | In the present study, we describe six patients who received autologous mesenchymal stem cell (MSC) therapy for symptomatic carpometacarpal (CMC) joint and hand osteoarthritis (OA). Six patients who received injections of adult autologous culture expanded MSCs in their thumb CMC joints were followed for 1 year posttreat... | ['Carpometacarpal Joints', 'Controlled Before-After Studies', 'Humans', 'Injections, Intra-Articular', 'Mesenchymal Stem Cell Transplantation', 'Osteoarthritis'] | 23,949,564 | [['A02.835.583.405.200'], ['E05.318.372.500.812', 'N05.715.360.330.500.812', 'N06.850.520.450.500.812'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.380'], ['E02.095.147.500.500.625', 'E04.936.225.687.625'], ['C05.550.114.606', 'C05.799.613']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Perception of front-of-pack labels according to social characteristics, nutritional knowledge and food purchasing habits. | OBJECTIVE: To identify patterns of perception of front-of-pack (FOP) nutrition labels and to determine social factors, nutritional knowledge and attention to packaging features related to such patterns.DESIGN: Cross-sectional. Perception was measured using indicators of understanding and acceptability of three simple F... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Cohort Studies', 'Commerce', 'Comprehension', 'Consumer Behavior', 'Cross-Sectional Studies', 'Diet', 'Educational Status', 'Feeding Behavior', 'Female', 'Food Labeling', 'Food Preferences', 'France', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged... | 23,174,385 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['J01.219'], ['F02.463.188.357'], ['F01.145.236'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.203.650.2... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Failure to detect an effect of prolactin on pulmonary surfactant and adrenal steroids in fetal sheep and rabbits. | Recent reports have indicated an association between low cord prolactin (PRL) and the occurrence of respiratory distress syndrome in premature infants, and it is reported that PRL administration increases the lecithin content of fetal rabbit lung. We administered 1 mg ovine PRL to 32 rabbit fetuses on day 24 of gestati... | ['Adrenal Cortex Hormones', 'Animals', 'Female', 'Gestational Age', 'Lung', 'Pregnancy', 'Prolactin', 'Pulmonary Surfactants', 'Rabbits', 'Sheep'] | 581,289 | [['D06.472.040'], ['B01.050'], ['G07.345.500.325.235.968', 'G08.686.320'], ['A04.411'], ['G08.686.784.769'], ['D06.472.699.322.576.773', 'D06.472.699.631.525.525', 'D12.644.548.691.525.525'], ['D27.505.954.796.600'], ['B01.050.150.900.649.313.968.700'], ['B01.050.150.900.649.313.500.380.791']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of the delayed mask for improved demonstration of aneurysms on intraarterial DSA. | PURPOSE: We retrospectively explored the use of the delayed mask technique for intraarterial digital subtraction angiography (IADSA) to demonstrate the anatomy of aneurysm necks.METHODS: The delayed mask technique was utilized in 22 patients who had craniotomies for aneurysms demonstrated at angiography. The operative ... | ['Angiography, Digital Subtraction', 'Humans', 'Intracranial Aneurysm', 'Retrospective Studies'] | 1,442,435 | [['E01.370.350.600.350.700.060', 'E01.370.350.700.060.060', 'E01.370.350.700.700.060', 'E01.370.350.760.060', 'E01.370.370.050.060'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.510.600', 'C14.907.055.635', 'C14.907.253.560.300'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.36... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Spatial Transcriptomic and miRNA Analyses Revealed Genes Involved in the Mesometrial-Biased Implantation in Pigs. | Implantation failure is a major cause of early embryonic loss. Normally, the conceptus attachment is initiated at mesometrial side of the uterus and then spread to the anti-mesometrial side in pigs, however, the mechanisms that direct the mesometrial-biased attachment are largely unknown. In this study, the histologica... | ['Animals', 'Embryo Implantation', 'Embryo Transfer', 'Embryo, Mammalian', 'Endometrium', 'Female', 'Gene Expression Profiling', 'MicroRNAs', 'Sequence Analysis, RNA', 'Swine', 'Trophoblasts', 'Uterus'] | 31,615,128 | [['B01.050'], ['G08.686.784.170.104.500'], ['E02.875.800.500', 'E05.820.800.500'], ['A16.254'], ['A05.360.319.679.490'], ['E05.393.332'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['E05.393.760.710'], ['B01.050.150.900.649.313.500.880'], ['A11.382.992', 'A16.254.500.766', 'A16.710.802'], ['... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence of Bartonella henselae antibodies in pet cats throughout regions of North America. | Cat exposure has been directly associated with the development of human Bartonella henselae infections, resulting in cat-scratch disease, bacillary angiomatosis, or bacteremia. The prevalence of serum antibody titers to B. henselae was determined for selected pet cats from 33 geographic locations throughout the United ... | ['Animals', 'Animals, Domestic', 'Antibodies, Bacterial', 'Bartonella Infections', 'Bartonella henselae', 'Cat Diseases', 'Cats', 'Climate', 'Geography', 'Insect Vectors', 'Models, Biological', 'North America', 'Prevalence', 'Siphonaptera'] | 7,561,200 | [['B01.050'], ['B01.050.050.116'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['C01.150.252.400.126.100'], ['B03.440.090.100.350', 'B03.660.050.030.040.350'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['G16.500.275.071', 'N06.230.300.100.250'], ['H... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Histo-clinical variation in multiple sclerosis: Heterogeneous proteolytic immunogenic processing. | Multiple sclerosis (MS) presents an incredible histo-clinical variation. It consists of an unpredictable series of relapses, remissions and stationary phases. The initial symptoms vary considerably. Any hypothesis of the pathology of MS must include an explanation of this oddity. Current theory suggests that MS is a co... | ['Central Nervous System', 'Disease Progression', 'Humans', 'Lipid Metabolism', 'Models, Biological', 'Models, Theoretical', 'Multiple Sclerosis', 'Oligodendroglia'] | 16,236,458 | [['A08.186'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.458'], ['E05.599.395'], ['E05.599'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['A08.637.600', 'A11.650.600']] | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparing the quality of life of school-age children with and without disabilities. | Quality of life of 76 school-age children with identified disabilities receiving special education services in public schools was compared to quality of life of 64 students without disabilities enrolled in Grades K-12. The Quality of Student Life Questionnaire (QSLQ) was used. Results indicated that the scores of stude... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Disabled Children', 'Female', 'Humans', 'Male', 'Persons with Mental Disabilities', 'Quality of Life'] | 12,123,394 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['M01.150.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.150.600'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837']] | ['Named Groups [M]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Time-course analysis of 3-epi-25-hydroxyvitamin D3 shows markedly elevated levels in early life, particularly from vitamin D supplementation in preterm infants. | BACKGROUND: An epimeric form of 25-hydroxyvitamin D3 (25(OH)D3) has recently been detected in clinical samples, with relatively high levels in infants. Little is known on 3-epi-25(OH)D3 formation and physiological function. Our objective was to study dynamics of 3-epi-25(OH)D3 formation during infancy.METHODS: 25(OH)D3... | ['Calcifediol', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Infant, Premature', 'Male', 'Vitamin D'] | 26,709,675 | [['D04.210.500.247.222.159.478.250', 'D04.210.500.247.808.146.478.250', 'D04.210.500.812.768.196.478.250', 'D10.570.938.146.478.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['D04.210.500.812.768']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Growth-plate-chondrocyte profiles and their orientation. | We studied the proximal tibial physes of mice, seven, fifteen, twenty-two, and twenty-eight days old, to define in mathematical terms the changes in cell profile and profile orientation among growth-plate zones and to determine if cell profile and profile orientation change with changes in the rate of growth. Using ele... | ['Aging', 'Animals', 'Cell Division', 'Growth Plate', 'Histological Techniques', 'Male', 'Mice', 'Mice, Inbred C57BL'] | 3,894,369 | [['G07.345.124'], ['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A02.835.232.251.352'], ['E01.370.225.750', 'E05.200.750'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mutagenic Effects of a 2-Deoxyribonolactone-Thymine Glycol Tandem DNA Lesion in Human Cells. | Tandem DNA lesions containing two contiguously damaged nucleotides are commonly formed by ionizing radiation. Their effects on replication in mammalian cells are largely unknown. Replication of isolated 2-deoxyribonolactone (L), thymine glycol (Tg), and tandem lesion 5'-LTg was examined in human cells. Although nearly ... | ['DNA', 'DNA Damage', 'DNA Repair', 'DNA Replication', 'DNA-Directed DNA Polymerase', 'HEK293 Cells', 'Humans', 'Mutagenesis', 'Mutagens', 'Nucleotides', 'Sugar Acids', 'Thymine'] | 31,860,280 | [['D13.444.308'], ['G05.200'], ['G02.111.222', 'G05.219'], ['G02.111.225', 'G05.226'], ['D08.811.913.696.445.308.300'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.558'], ['D27.888.569.468'], ['D09.408.620', 'D13.695'], ['D02.241.081.844', 'D02.241.511.902', 'D09.811']... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Robust encoding of scene anticipation during human spatial navigation. | In a familiar city, people can recall scene views (e.g., a particular street corner scene) they could encounter again in the future. Complex objects with multiple features are represented by multiple neural units (channels) in the brain, but when anticipating a scene view, the kind of feature that is assigned to a spec... | ['Adult', 'Behavior', 'Decision Making', 'Female', 'Humans', 'Male', 'Motion', 'Parietal Lobe', 'Prefrontal Cortex', 'Space Perception', 'Spatial Navigation', 'Task Performance and Analysis', 'Young Adult'] | 27,874,089 | [['M01.060.116'], ['F01.145'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.482'], ['A08.186.211.200.885.287.500.670'], ['A08.186.211.200.885.287.500.270.700'], ['F02.463.593.778'], ['F01.145.875.797', 'F02.463.641'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600'], ['M01.060.116.81... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Electrophysiologic studies of the heart in patients with rheumatoid arthritis. | We investigated the electrophysiological properties of the heart in patients with definite or classical rheumatoid arthritis using programmed electrical stimulation techniques. Twelve patients with rheumatoid arthritis and without evidence of organic heart disease or arrhythmia detectable with serial electrocardiograms... | ['Adult', 'Arthritis, Rheumatoid', 'Electrophysiology', 'Heart', 'Humans', 'Middle Aged'] | 2,298,520 | [['M01.060.116'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['H01.158.344.528', 'H01.158.782.236'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Named Groups [M]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Generation of CFUC suppressor T cells in vitro: VII. T derived colony inhibitory activity (Td/CIA) has no suppressor effect on in vitro immunoglobulin production. | T derived colony inhibitory activity (Td/CIA) was obtained from unstimulated T cells from aplastic anemia patients (SAA), or from PWM primed normal T cells. Td/CIA suppressed CFUC growth of normal allogeneic marrow to less than 30% of expected growth. Td/CIA was then added to normal peripheral blood T and B cells, prim... | ['Anemia, Aplastic', 'Antibody Formation', 'Colony-Forming Units Assay', 'Humans', 'Immunoglobulins', 'T-Lymphocytes, Regulatory'] | 6,225,656 | [['C15.378.071.085', 'C15.378.190.223.250'], ['G12.450.050.370.250'], ['E01.370.225.500.383', 'E05.200.500.383', 'E05.242.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485', 'D12.776.124.790.651', 'D12.776.377.715.548'], ['A11.118.637.555.567.550.500.700', 'A11.118.637.555.567.569.200.700', ... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Experiments with cholera toxin detoxified with glutaraldehyde. | Studies on the production, purification, and detoxification of cholera toxin are reported. The toxin was first partially purified with aluminium hydroxide and further purification was effected with Bio Gel A-5m and Sephadex G-75. The toxins were detoxified with glutaraldehyde; the toxoids so obtained, when injected int... | ['Aldehydes', 'Animals', 'Antibody Formation', 'Antitoxins', 'Cholera', 'Glutaral', 'Rabbits', 'Toxins, Biological'] | 4,219,758 | [['D02.047'], ['B01.050'], ['G12.450.050.370.250'], ['D12.776.124.486.485.114.573.601', 'D12.776.124.790.651.114.573.601', 'D12.776.377.715.548.114.573.601', 'D20.215.401.601'], ['C01.150.252.400.959.347'], ['D02.047.532'], ['B01.050.150.900.649.313.968.700'], ['D23.946']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Setting realistic recovery targets for two interacting endangered species, sea otter and northern abalone. | Failure to account for interactions between endangered species may lead to unexpected population dynamics, inefficient management strategies, waste of scarce resources, and, at worst, increased extinction risk. The importance of species interactions is undisputed, yet recovery targets generally do not account for such ... | ['Animals', 'British Columbia', 'Conservation of Natural Resources', 'Endangered Species', 'Gastropoda', 'Models, Biological', 'Otters', 'Population Dynamics', 'Stochastic Processes'] | 23,083,059 | [['B01.050'], ['Z01.107.567.176.160'], ['J01.256', 'N06.230.080'], ['B01.050.050.565', 'G16.500.275.157.049.250', 'N06.230.080.200', 'N06.230.124.049.250'], ['B01.050.500.644.400'], ['E05.599.395'], ['B01.050.150.900.649.313.750.250.575.600'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['E05.318.740.996', '... | ['Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Age- and feeding-dependent production of carbonyl compounds in hypoxic heart. The role of carbonyls produced in connective tissue modification. | The concentration of reactive lipid metabolites (malondialdehyde, formaldehyde, acetaldehyde and acetone) was assayed in rat heart reperfusates after 30 min ischemia in animals of different age and kept on different feeding regimes. It was revealed that there is no difference in the concentration of reactive carbonyl c... | ['Acetone', 'Aging', 'Aldehydes', 'Amino Acids', 'Animals', 'Connective Tissue', 'Cyanogen Bromide', 'Diet', 'Hypoxia', 'In Vitro Techniques', 'Lipid Peroxidation', 'Male', 'Myocardial Reperfusion Injury', 'Rats', 'Rats, Wistar', 'Solubility'] | 8,028,397 | [['D02.522.064'], ['G07.345.124'], ['D02.047'], ['D12.125'], ['B01.050'], ['A10.165'], ['D01.139.300.050.100', 'D01.625.175'], ['G07.203.650.240'], ['C23.888.852.079'], ['E05.481'], ['G02.111.515', 'G03.295.531.587'], ['C14.280.238.615', 'C14.280.647.625', 'C14.907.585.625', 'C14.907.725.600', 'C23.550.767.877.500'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag. | We introduce a new method for purifying recombinant proteins expressed in bacteria using a highly specific, inducible, self-cleaving protease tag. This tag is comprised of the Vibrio cholerae MARTX toxin cysteine protease domain (CPD), an autoprocessing enzyme that cleaves exclusively after a leucine residue within the... | ['Animals', 'Biochemistry', 'Coenzyme A Ligases', 'Genetic Vectors', 'Histidine', 'Matrix Metalloproteinase 12', 'Mice', 'Oligopeptides', 'Peptide Hydrolases', 'Protein Stability', 'Protein Structure, Tertiary', 'Protozoan Proteins', 'Recombinant Fusion Proteins', 'Solubility'] | 19,956,581 | [['B01.050'], ['H01.158.201', 'H01.181.122'], ['D08.811.464.267.500'], ['G05.360.337'], ['D12.125.072.329', 'D12.125.142.308'], ['D08.811.277.656.300.480.525.700.500', 'D08.811.277.656.675.374.525.700.500', 'D12.644.276.848.500', 'D12.776.467.836.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.644.456'], ['D0... | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Biophysical studies of infectious pancreatic necrosis virus. | The molecular weight of infectious pancreatic necrosis virus (IPNV) has been determined by analytical ultracentrifugation and dynamic light scattering. The sedimentation coefficient of the virus was found to be 435S. The average value for molecular weight is (55 +/- 7) x 106. The virus genome consists of two segments o... | ['Animals', 'Capsid', 'Cell Line', 'Cyprinidae', 'Molecular Weight', 'Peptides', 'RNA, Viral', 'Reoviridae', 'Salmonidae', 'Trout', 'Viral Proteins', 'Water'] | 558,343 | [['B01.050'], ['A21.249.500.250'], ['A11.251.210'], ['B01.050.150.900.493.200.244'], ['G02.494'], ['D12.644'], ['D13.444.735.828'], ['B04.820.223.719'], ['B01.050.150.900.493.817.750'], ['B01.050.150.900.493.817.750.825'], ['D12.776.964'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Medical management of acromegaly with bromocriptine. Effects of continuous treatment for over three years. | Eighty-seven patients with active acromegaly were treated with bromocriptine for periods of up to 42 months. On treatment, 82 of these patients noted a rapid alleviation of one or more symptoms of their disease. In 67 patients, the mean growth hormone level of four values taken through the day fell by 14 mu/L or more, ... | ['Acromegaly', 'Adolescent', 'Adult', 'Aged', 'Bromocriptine', 'Diabetes Complications', 'Growth Hormone', 'Humans', 'Middle Aged', 'Time Factors'] | 745,579 | [['C05.116.132.082', 'C10.228.140.617.738.250.100', 'C19.700.355.179'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D03.132.327.412.100', 'D03.633.400.439.131', 'D03.633.400.562.100'], ['C19.246.099'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[The BAR-Valtrac for the colon]. | The authors present their experience with biofragmentable anastomosis in the area of the colon in 42 patients where they used a biofragmentable ring Valtrac, Davis-Geck Co. to restores continuity after resection. The authors focus their attention on the peroperative technical difficulty of construction of the anastomos... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anastomosis, Surgical', 'Colon', 'Female', 'Humans', 'Male', 'Middle Aged'] | 10,746,079 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.035'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Generation of henipavirus nucleocapsid proteins in yeast Saccharomyces cerevisiae. | Hendra and Nipah viruses are newly emerged, zoonotic viruses and their genomes have nucleotide and predicted amino acid homologies placing them in the family Paramyxoviridae. Currently these viruses are classified in the new genus Henipavirus, within the subfamily Paramyxovirinae, family Paramyxoviridae. The genes enco... | ['Amino Acid Sequence', 'Animals', 'Antibodies, Viral', 'Centrifugation, Density Gradient', 'Chiroptera', 'Cloning, Molecular', 'Gene Expression', 'Genes, Viral', 'Genetic Vectors', 'Henipavirus', 'Henipavirus Infections', 'Horses', 'Humans', 'Mass Spectrometry', 'Microscopy, Electron, Transmission', 'Nucleocapsid Prot... | 17,123,657 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['E05.181.724.336', 'E05.196.941.336'], ['B01.050.150.900.649.313.937'], ['E05.393.220'], ['G05.297'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
The molecular evolution of catalatic hydroperoxidases: evidence for multiple lateral transfer of genes between prokaryota and from bacteria into eukaryota. | The past decade has produced an increasing number of reports on horizontal gene transfer between prokaryotic organisms. Only recently, with the flood of available whole genome sequence data and a renewed intensity of the debate about the universal tree of life, a very few reports on lateral gene transfer (LGT) from pro... | ['Bacteria', 'Catalase', 'Catalysis', 'Eukaryota', 'Eukaryotic Cells', 'Evolution, Molecular', 'Fungi', 'Gene Transfer, Horizontal', 'Genome', 'Heme', 'Phylogeny', 'Plants', 'Proteins'] | 12,777,528 | [['B03'], ['D08.811.682.732.332'], ['G02.130'], ['B01'], ['A11.450'], ['G05.045.250', 'G16.075.250'], ['B01.300'], ['G05.728.390'], ['G05.360.340'], ['D03.383.129.578.840.500.640.587', 'D03.633.400.909.500.640.587', 'D04.345.783.500.640.587', 'D23.767.727.640.587'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B01.650'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Establishment and characterization of two new cell lines derived from squamous cell carcinoma of the tongue in Chinese patients. | Two new cell lines derived from squamous cell carcinoma of the tongue, T1/CUHK and T2/CUHK, have been established in culture. Analysis of the morphology, ultrastructure, chromosome number, spheroid formation and immunohistochemical properties of the two cell lines demonstrated that they are both well characterized. T1/... | ['Animals', 'Biopsy', 'Carcinoma, Squamous Cell', 'Cell Line', 'China', 'Chromosomes, Human', 'Culture Techniques', 'DNA Probes', 'Hong Kong', 'Humans', 'Keratins', 'Mice', 'Mice, Nude', 'Neoplasm Transplantation', 'Papillomaviridae', 'Tongue Neoplasms', 'Transplantation, Heterologous', 'Tumor Cells, Cultured'] | 1,280,031 | [['B01.050'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.251.210'], ['Z01.252.474.164'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['E05.481.500'], ['D13.444.60... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Deoxycholic acid promotes the growth of colonic aberrant crypt foci. | AKR/J mice are resistant to the tumorigenic properties of the colon carcinogen, azoxymethane (AOM). Following AOM exposure, limited numbers of preneoplastic lesions, referred to as aberrant crypt foci (ACF), are formed in the colon, and their progression to tumors rarely occurs. To determine whether genetic resistance ... | ['Animals', 'Azoxymethane', 'Cadherins', 'Carcinogens', 'Cell Nucleus', 'Colon', 'Colonic Neoplasms', 'Deoxycholic Acid', 'Detergents', 'Hyperplasia', 'Male', 'Mice', 'Mice, Inbred AKR', 'Precancerous Conditions', 'Protein Transport', 'beta Catenin'] | 17,091,474 | [['B01.050'], ['D02.172.080'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['D27.888.569.100'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Uptake of silver nanoparticles by DHA-treated cancer cells examined by surface-enhanced Raman spectroscopy in a microfluidic chip. | This paper reports on the synthesis and application of biocompatible and sensitive SERS nanoparticles for the study of uptake of nanoparticles into living cells in a microfluidic chip through surface-enhanced Raman spectroscopy (SERS). The nanoparticles were fabricated as beta-cyclodextrin-coated silver nanoparticles (... | ['Antineoplastic Agents', 'Artemisinins', 'Cell Line, Tumor', 'Cell Survival', 'Folic Acid', 'Humans', 'Lab-On-A-Chip Devices', 'Metal Nanoparticles', 'Microfluidic Analytical Techniques', 'Silver', 'Spectrum Analysis, Raman'] | 28,247,889 | [['D27.505.954.248'], ['D01.248.497.158.685.750.212', 'D01.339.431.374.212', 'D01.650.550.750.200', 'D02.389.338.055', 'D02.455.849.765.211'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D03.633.100.733.631.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.305.343.500'], ['J01.637.512.600.500'], ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[The ethics of ethnography revisited: learning from documentaries]. | This article offers a comparison of the legal suits filed by the interviewees against the director of the documentary ?tre et avoir (to have and to be) with the rights of interviewees in ethnographic investigations, focusing particularly on image copyrights and labor law. To say that interviewees contribute to such inv... | ['Anthropology, Cultural', 'Copyright', 'France', 'Humans', 'Motion Pictures'] | 21,858,620 | [['I01.076.201'], ['I01.880.604.583.458.300', 'L01.737.360', 'N03.706.535.518.300'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.280.500.598', 'K01.093.545', 'L01.178.590.500', 'L01.178.820.090.598']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 |
pymzML v2.0: introducing a highly compressed and seekable gzip format. | Motivation: In the new release of pymzML (v2.0), we have optimized the speed of this established tool for mass spectrometry data analysis to adapt to increasing amounts of data in mass spectrometry. Thus, we integrated faster libraries for numerical calculations, improved data retrieving algorithms and have optimized t... | ['Algorithms', 'Data Compression', 'Mass Spectrometry', 'Proteomics', 'Software'] | 29,394,323 | [['G17.035', 'L01.224.050'], ['L01.224.308.189', 'L01.224.800.500', 'L01.470.500'], ['E05.196.566'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['L01.224.900']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
The lateral pillar classification of Legg-Calv?-Perthes disease. | To determine the predictive value of a new classification system for Legg-Perthes, 93 hips in 86 patients with radiographic follow-up to maturity were reviewed. All patients were treated by bracing at the Texas Scottish Rite Hospital from 1970 to 1980. Hips were classified during the fragmentation stage of disease into... | ['Age Factors', 'Braces', 'Child', 'Femur Head', 'Humans', 'Legg-Calve-Perthes Disease', 'Prognosis', 'Radiography', 'Retrospective Studies'] | 1,552,014 | [['N05.715.350.075', 'N06.850.490.250'], ['E07.858.442.743.319'], ['M01.060.406'], ['A02.835.232.043.150.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.852.175.570'], ['E01.789'], ['E01.370.350.700'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.3... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The time-course of visual categorizations: you spot the animal faster than the bird. | BACKGROUND: Since the pioneering study by Rosch and colleagues in the 70s, it is commonly agreed that basic level perceptual categories (dog, chair...) are accessed faster than superordinate ones (animal, furniture...). Nevertheless, the speed at which objects presented in natural images can be processed in a rapid go/... | ['Adult', 'Animals', 'Attention', 'Birds', 'Cognition', 'Concept Formation', 'Discrimination Learning', 'Dogs', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pattern Recognition, Visual', 'Reaction Time', 'Visual Perception'] | 19,536,292 | [['M01.060.116'], ['B01.050'], ['F02.830.104.214'], ['B01.050.150.900.248'], ['F02.463.188'], ['F02.463.785.233'], ['F02.463.425.280'], ['B01.050.150.900.649.313.750.250.216.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['E05.796.817', 'F02.... | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Barriers to acceptance and adherence of antiretroviral therapy in urban Zambian women: a qualitative study. | Sub-Saharan Africa contains over 60% of the world's HIV infections and Zambia is among the most severely affected countries in the region. As antiretroviral programs have been rapidly expanding, the long-term success of these programs depends on a good understanding of the behavioral determinants of acceptance and adhe... | ['Anti-Retroviral Agents', 'Fear', 'Female', 'HIV Infections', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Medication Adherence', 'Qualitative Research', 'Surveys and Questionnaires', 'Urban Population', 'Zambia'] | 19,085,223 | [['D27.505.954.122.388.077'], ['F01.470.361'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500.600.500', 'F01.145.488.887.500.600.500... | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
All-trans retinoyl beta-glucose: chemical synthesis, growth-promoting activity, and metabolism in the rat. | All-trans retinoyl beta-glucose was chemically synthesized in good yield by reaction of retinoyl fluoride with glucose. Retinoyl glucose, which is soluble in water, shows growth-promoting activity similar to retinyl acetate in vitamin A-deficient rats. In metabolic studies, retinoyl glucose was found to be hydrolyzed t... | ['Animals', 'Body Weight', 'Chromatography, High Pressure Liquid', 'Glucose', 'Male', 'Rats', 'Rats, Inbred Strains', 'Retinoids', 'Tretinoin', 'Vitamin A Deficiency'] | 1,794,956 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E05.196.181.400.300'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['D02.455.326.271.... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antibiotic treatment of experimental endocarditis due to vancomycin- and ampicillin-resistant Enterococcus faecium. | We compared ciprofloxacin, rifampin, and gentamicin treatments, alone and in combination, for 5 days in the therapy of experimental aortic valve endocarditis in rats caused by a clinical isolate of vancomycin-resistant Enterococcus faecium. The MICs and MBCs of vancomycin, ciprofloxacin, rifampin, and gentamicin were 2... | ['Ampicillin Resistance', 'Animals', 'Ciprofloxacin', 'Disease Models, Animal', 'Drug Resistance, Microbial', 'Drug Therapy, Combination', 'Endocarditis, Bacterial', 'Enterococcus faecalis', 'Gentamicins', 'Gram-Positive Bacterial Infections', 'Male', 'Microbial Sensitivity Tests', 'Rats', 'Rats, Sprague-Dawley', 'Rifa... | 8,257,125 | [['G06.099.225.500.600.050', 'G06.225.347.500.600.050', 'G07.690.773.984.269.347.500.600.050'], ['B01.050'], ['D03.633.100.810.835.322.186'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G06.225', 'G07.690.773.984.269'], ['E02.319.310'], ['C01.150.252.245', 'C01.190.249', 'C14.260.249', 'C14.280.282.407'], ['B03.35... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interview with J?rg Zimmermann, global head of oncology & exploratory chemistry at Novartis. | Dr J?rg Zimmermann is the inventor of the drug imatinib (Gleevec(®), Glivec(®)), which entered the market in 2001 and revolutionized the treatment of chronic myelogenous leukemia. He talks to Future Medicinal Chemistry about his career as a medicinal chemist, current issues in pharmaceutical R&D and his experiences of ... | ['Antineoplastic Agents', 'Benzamides', 'Chemistry, Pharmaceutical', 'Combinatorial Chemistry Techniques', 'Drug Discovery', 'Drug Industry', 'Humans', 'Imatinib Mesylate', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Piperazines', 'Pyrimidines', 'Research Personnel', 'Workforce'] | 21,426,055 | [['D27.505.954.248'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['H01.158.703.007', 'H01.181.466'], ['E05.197.312', 'J01.897.836.249.249'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['J01.576.655.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.065.277.456', 'D02.2... | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 |
The investigation of systolic and diastolic leaflet kinematics of bioprostheses with a new in-vitro test method. | OBJECTIVES: We aimed to investigate leaflet kinematics of bioprostheses with a novel high-speed imaging method.MATERIAL AND METHODS: High-speed-imaging (1000 Hz) was used to evaluate leaflet kinematics of the Carpentier-Edwards Perimount Magna (PM) and Magna Ease (PME) aortic bioprostheses. Both prostheses (diameter 23... | ['Aortic Valve', 'Biomechanical Phenomena', 'Bioprosthesis', 'Evaluation Studies as Topic', 'Heart Valve Prosthesis', 'Hemodynamics', 'Humans', 'In Vitro Techniques', 'Prosthesis Design'] | 26,358,833 | [['A07.541.510.110'], ['G01.154.090', 'G01.374.089'], ['E07.695.100'], ['E05.337', 'N05.715.360.335'], ['E07.695.310'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['E05.320.550', 'E07.695.680']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Does insurance against punishment undermine cooperation in the evolution of public goods games? | In a public goods game, cooperation can be a stable outcome if defectors are facing efficient punishment. In some public goods systems, punishment is undermined by an insurance system where speculators buy a policy that sequentially covers all punishment costs. Here, we study a simple model to investigate the question ... | ['Algorithms', 'Biological Evolution', 'Cooperative Behavior', 'Game Theory', 'Humans', 'Interpersonal Relations', 'Models, Statistical', 'Punishment', 'Social Behavior', 'Transportation'] | 23,291,010 | [['G17.035', 'L01.224.050'], ['G05.045', 'G16.075'], ['F01.145.813.115'], ['G17.388'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['F02.463.425.770.571', 'I01.880.630.716'], ['F01.145.813'], ['J01.937']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 |
Properties of Bacteroides fragilis antigens with specificity B. | Five different serologically active preparations were extracted from Bacteroides ovatus ATCC 8483 strain. These substances and sixteen preparations of culture supernatants all giving a positive reaction with antiserum of serotype B were used as inhibitors in haemagglutination inhibition test. The results showed that su... | ['Animals', 'Antigens, Bacterial', 'Bacteroides fragilis', 'Endotoxins', 'Hemagglutination Tests', 'Immunodiffusion', 'Rabbits', 'Serotyping'] | 2,579,527 | [['B01.050'], ['D23.050.161'], ['B03.440.080.094.152.400', 'B03.440.425.410.194.152.400'], ['D23.946.123.329'], ['E01.370.225.812.735.050.375', 'E05.200.812.735.050.375', 'E05.478.594.760.050.375'], ['E01.370.225.812.735.645.350', 'E05.200.812.735.645.350', 'E05.478.594.760.645.350', 'E05.478.605.492.350'], ['B01.050.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Growth of retinal capillary endothelia using pericyte conditioned medium. | Long-term cultures of bovine retinal capillary endothelial cells (BRCEC) have been established using bovine retinal pericyte conditioned medium (PCM). PCM had greater mitogenic activity on BRCEC than unconditioned medium (P less than 0.01). The mitogenic activity of PCM was not cell specific since bovine Tenon's fibrob... | ['Animals', 'Capillaries', 'Cattle', 'Cells, Cultured', 'Culture Media', 'Cytological Techniques', 'Epithelium', 'Retinal Vessels'] | 3,312,077 | [['B01.050'], ['A07.015.461.165'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['D27.720.470.305', 'E07.206'], ['E01.370.225.500', 'E05.200.500', 'E05.242'], ['A10.272'], ['A07.015.611']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phage response to CRISPR-encoded resistance in Streptococcus thermophilus. | Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated genes are linked to a mechanism of acquired resistance against bacteriophages. Bacteria can integrate short stretches of phage-derived sequences (spacers) within CRISPR loci to become phage resistant. In this study, we further chara... | ['Base Sequence', 'DNA, Bacterial', 'DNA, Intergenic', 'DNA, Viral', 'Genome, Bacterial', 'Genome, Viral', 'Host-Pathogen Interactions', 'Models, Genetic', 'Molecular Sequence Data', 'Repetitive Sequences, Nucleic Acid', 'Sequence Homology, Nucleic Acid', 'Streptococcus Phages', 'Streptococcus thermophilus'] | 18,065,545 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.212'], ['D13.444.308.324', 'G05.360.340.024.220'], ['D13.444.308.568'], ['G05.360.340.358.207'], ['G05.360.340.358.840'], ['G06.462', 'G16.527.200'], ['E05.599.395.397'], ['L01.453.245.667'], ['G02.111.570.080.708', 'G05.360.080.708'], ['G02.111.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Severe hemoptysis in a child after the Fontan procedure. | There is an increased incidence of pulmonary hemorrhage and hemoptysis among patients with congenital heart disease (CHD). The pathophysiology of pulmonary hemorrhage in CHD includes pulmonary hypertension, pulmonary venous congestion, aorto-pulmonary collaterals, pulmonary arteriovenous malformations, and dilated bron... | ['Anesthesia, General', 'Bronchoscopy', 'Cardiac Catheterization', 'Child', 'Fontan Procedure', 'Heart Defects, Congenital', 'Hemoptysis', 'Humans', 'Male', 'Postoperative Complications'] | 15,910,355 | [['E03.155.197'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['M01.060.406'], ['E04.035.410.295', 'E04.100.376.410.295', 'E04.100.376.724.500', 'E04.100.814.868.875.295', 'E04.928.220.370.295', 'E04.928.220.560.500'], ['C14.24... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
On the Two-Dimensional Simplification of Three-Dimensional Cementless Hip Stem Numerical Models. | Three-dimensional (3D) finite element (FE) models are commonly used to analyze the mechanical behavior of the bone under different conditions (i.e., before and after arthroplasty). They can provide detailed information but they are numerically expensive and this limits their use in cases where large or numerous simulat... | ['Finite Element Analysis', 'Hip', 'Mechanical Phenomena', 'Prostheses and Implants', 'Shear Strength', 'Stress, Mechanical'] | 27,925,636 | [['E05.355'], ['A01.378.610.400'], ['G01.374'], ['E07.695'], ['G01.374.820'], ['G01.374.835']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Self-test web-based pure-tone audiometry: validity evaluation and measurement error analysis. | BACKGROUND: Potential methods of application of self-administered Web-based pure-tone audiometry conducted at home on a PC with a sound card and ordinary headphones depend on the value of measurement error in such tests.OBJECTIVE: The aim of this research was to determine the measurement error of the hearing threshold ... | ['Adolescent', 'Adult', 'Audiometry, Pure-Tone', 'Auditory Threshold', 'Child', 'Diagnosis, Computer-Assisted', 'Diagnostic Self Evaluation', 'Female', 'Hearing Disorders', 'Humans', 'Internet', 'Male', 'Middle Aged', 'Telemedicine', 'Young Adult'] | 23,583,917 | [['M01.060.057'], ['M01.060.116'], ['E01.370.382.375.060.055'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['M01.060.406'], ['E01.158', 'L01.313.500.750.100.158'], ['E01.370.360', 'F01.752.747.792.220'], ['C09.218.458', 'C10.597.751.418', 'C23.888.592.763.393'], ['B01.050.150.900.649.313.988.400... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Molecularly Imprinted Nanogels Acquire Stealth In Situ by Cloaking Themselves with Native Dysopsonic Proteins. | Protein corona formation was regulated on the surface in vivo by molecular imprinting to enable polymeric nanogels to acquire stealth upon intravenous administration. Albumin, the most abundant protein in blood, was selected as a distinct protein component of protein corona for preparing molecularly imprinted nanogels ... | ['Animals', 'Chromatography, Gel', 'Drug Carriers', 'Fluorescence Resonance Energy Transfer', 'Gels', 'HeLa Cells', 'Humans', 'Mice', 'Molecular Imprinting', 'NIH 3T3 Cells', 'Nanoparticles', 'Opsonin Proteins', 'Protein Corona', 'Serum Albumin, Human', 'Surface Plasmon Resonance'] | 28,455,941 | [['B01.050'], ['E05.196.181.400.250'], ['D26.255.260', 'E02.319.300.380'], ['E05.196.712.516.600.676.500', 'G01.154.240.280', 'G02.111.255.280'], ['D20.280.320', 'D26.255.165.320'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Neurotensin receptor 1 determines the outcome of non-small cell lung cancer. | PURPOSE: This study aimed to investigate the role of the neurotensin/neurotensin receptor I (NTSR1) complex in non-small cell lung cancer (NSCLC) progression.EXPERIMENTAL DESIGN: The expression of neurotensin and NTSR1 was studied by transcriptome analysis and immunohistochemistry in two series of 74 and 139 consecutiv... | ['Adenocarcinoma', 'Aged', 'Animals', 'Carcinoma, Non-Small-Cell Lung', 'Cell Line, Tumor', 'Female', 'Gene Expression Profiling', 'Humans', 'Immunohistochemistry', 'Kaplan-Meier Estimate', 'Lung Neoplasms', 'Lymphatic Metastasis', 'Male', 'Mice', 'Mice, Nude', 'Middle Aged', 'Multivariate Analysis', 'Neoplasms, Experi... | 20,810,387 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['B01.050'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Small bowel adenocarcinoma phenotyping, a clinicobiological prognostic study. | BACKGROUND: Small bowel adenocarcinoma (SBA) is a rare tumour with a poor prognosis. Molecular biology data on SBA carcinogenesis are lacking.METHODS: Expression of HER2, â-catenin, p53 and mismatch repair (MMR) protein was assessed by immunohistochemistry. KRAS, V600E BRAF mutations and microsatellite instability were... | ['Adenocarcinoma', 'Adult', 'Aged', 'Female', 'Humans', 'Immunohistochemistry', 'Intestinal Neoplasms', 'Male', 'Microsatellite Instability', 'Middle Aged', 'Phenotype', 'Prognosis', 'Survival Analysis'] | 24,196,786 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.5... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Filling the gap: Evidence for a spatial differentiation in trace eyeblink conditioning. | Trace eyeblink conditioning is used as a translational model of declarative memory but restricted to the temporal domain. Potential spatial aspects have never been experimentally addressed. We employed a spatiotemporal trace eyeblink conditioning paradigm in which a spatial dimension (application side of the unconditio... | ['Adult', 'Blinking', 'Conditioning, Classical', 'Female', 'Humans', 'Male', 'Memory, Episodic', 'Young Adult'] | 28,610,951 | [['M01.060.116'], ['G11.561.731.127', 'G14.152'], ['F02.463.425.179.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.254'], ['M01.060.116.815']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Human Foramen Magnum Area and Posterior Cranial Fossa Volume Growth in Relation to Cranial Base Synchondrosis Closure in the Course of Child Development. | BACKGROUND: To date, no study has compared the evolution of the foramen magnum area (FMA) and the posterior cranial fossa volume (PCFV) with the degree of cranial base synchondrosis ossification.OBJECTIVE: To illustrate these features in healthy children.METHODS: The FMA, the PCFV, and the ossification of 12 synchondro... | ['Adolescent', 'Child', 'Child Development', 'Child, Preschool', 'Cranial Fossa, Posterior', 'Cranial Sutures', 'Female', 'Foramen Magnum', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Osteogenesis', 'Retrospective Studies', 'Sex Characteristics', 'Skull Base', 'Tomography, X-Ray Computed'] | 27,341,342 | [['M01.060.057'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['M01.060.406.448'], ['A01.456.830.200', 'A02.835.232.781.750.400'], ['A02.835.232.781.200'], ['A02.835.232.781.572.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['G07.345.500.325.377.625.050.500.729',... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Recurrent acute stent thrombosis associated with protein C and S deficiencies. | Protein C and protein S deficiencies may uncommonly be responsible for coronary arterial thrombosis. We report a young woman with recurrent acute stent thrombosis due to the deficiency of protein C and S. After coronary stenting, stent thrombosis occurred two times despite aggressive antiplatelet therapy, including asp... | ['Acute Disease', 'Adult', 'Coronary Angiography', 'Coronary Thrombosis', 'Electrocardiography', 'Female', 'Humans', 'Protein C Deficiency', 'Protein S Deficiency', 'Recurrence', 'Stents'] | 16,502,322 | [['C23.550.291.125'], ['M01.060.116'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250.290', 'C14.907.355.830.220', 'C14.907.585.250.290'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.378.100.100.6... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The primary structure of human liver manganese superoxide dismutase. | The complete amino acid sequence of manganese superoxide dismutase from human liver was determined. The sequence was deduced following characterization of the peptides obtained from tryptic, chymotryptic, and Staphylococcus aureus digests of the apoprotein. Chemical cleavage with dimethyl sulfoxide-hydrobromic acid was... | ['Amino Acid Sequence', 'Endopeptidases', 'Escherichia coli', 'Geobacillus stearothermophilus', 'Humans', 'Liver', 'Macromolecular Substances', 'Peptide Fragments', 'Saccharomyces cerevisiae', 'Species Specificity', 'Superoxide Dismutase'] | 6,386,798 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D08.811.277.656.300'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B03.300.390.400.158.400.400', 'B03.353.500.100.400.400', 'B03.510.100.100.400.400', 'B03.510.415.400.158.400.400', 'B03.510.460.410.158.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Mono- and combination drug therapies in hospitalized patients with bipolar depression. Data from the European drug surveillance program AMSP. | BACKGROUND: For the pharmacological treatment of bipolar depression several guidelines exist. It is largely unknown, to what extent the prescriptions in daily clinical routine correspond to these evidence based recommendations and which combinations of psychotropic drugs are frequently used.METHODS: The prescriptions o... | ['Anticonvulsants', 'Antidepressive Agents', 'Antipsychotic Agents', 'Bipolar Disorder', 'Drug Prescriptions', 'Drug Therapy, Combination', 'Europe', 'Humans', 'Inpatients', 'Lithium', 'Pharmacovigilance', 'Product Surveillance, Postmarketing'] | 22,998,655 | [['D27.505.954.427.080'], ['D27.505.954.427.700.122'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['F03.084.500'], ['E02.319.307', 'N02.421.668.778.500'], ['E02.319.310'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['D01.268.549.450', '... | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Fronto-temporal-lobe atrophy in early-stage Alzheimer's disease identified using an improved detection methodology. | Alzheimer's disease (AD) is associated with widespread brain atrophy including structures subserving memory. We applied an improved structural detection methodology to examine the less well known progression of atrophy in early-stage AD. We sought to i) longitudinally study volumetric differences in patients with early... | ['Aged', 'Alzheimer Disease', 'Atrophy', 'Cognition Disorders', 'Demography', 'Early Diagnosis', 'Female', 'Frontal Lobe', 'Hippocampus', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Neuropsychological Tests', 'Severity of Illness Index', 'Temporal Lobe'] | 17,399,959 | [['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['C23.300.070'], ['F03.615.250'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['E01.390'], ['A08.186.211.200.885.287.500.270'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Use of stapling instruments in surgery for aneurysms of the aorta. | Since their inception, surgical stapling devices have been used almost exclusively in pulmonary and gastrointestinal procedures. We present our experience with surgical staplers in operations for aneurysms of the aorta. Three illustrative case reports are presented that demonstrate the applicability of surgical staplin... | ['Aorta, Thoracic', 'Aortic Aneurysm', 'Female', 'Humans', 'Male', 'Methods', 'Middle Aged', 'Postoperative Complications', 'Surgical Staplers'] | 6,882,074 | [['A07.015.114.056.372'], ['C14.907.055.239', 'C14.907.109.139'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['M01.060.116.630'], ['C23.550.767'], ['E07.858.700.750']] | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Sorption and contact-activating properties of the <<biograft-artery>> anastomosis zone: effect of suture material (communication II)]. | The authors have carried out a comparative analysis of the interaction between two types of suture material with blood components, as well as studied the effect of heparin-mediated modification on the sorption and contact-activating processes in the zone of the anastomosis. The blood-compatible properties of the latter... | ['Adsorption', 'Anastomosis, Surgical', 'Fibrinolytic Agents', 'Heparin', 'Humans', 'Platelet Activating Factor', 'Sutures', 'Tensile Strength'] | 19,156,039 | [['G01.030', 'G02.020'], ['E04.035'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.100.291.211.500', 'D02.092.063.291.211.500', 'D02.092.877.883.333.710', 'D02.675.276.232.710', 'D10.570.755.375.760.400.985.910', '... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Interaction of acetyl-CoA carboxylase from the rat liver with analogs of activated carbon dioxide and ATP]. | The interaction of rat liver Ac-CoA-carboxylase with reactive and stable analogs of carbon dioxide and phosphoric acid mixed anhydrides--hypothetic intermediate of the enzyme reaction--has been studied. Carbamoylphosphate showed substrate properties, whereas phosphonacetic acid and beta-oxopropyl-alpha, alpha-diphospho... | ['Acetate-CoA Ligase', 'Adenosine Triphosphate', 'Animals', 'Carbamyl Phosphate', 'Carbon Dioxide', 'Coenzyme A Ligases', 'Liver', 'Rats'] | 2,897,623 | [['D08.811.464.267.500.200'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D02.241.081.251.145', 'D02.705.400.100'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D08.811.464.267.500'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Theoretical limitations on functional imaging resolution in auditory cortex. | Functional imaging can reveal detailed organizational structure in cerebral cortical areas, but neuronal response features and local neural interconnectivity can influence the resulting images, possibly limiting the inferences that can be drawn about neural function. Discerning the fundamental principles of organizatio... | ['Acoustic Stimulation', 'Action Potentials', 'Algorithms', 'Animals', 'Auditory Cortex', 'Auditory Perception', 'Brain Mapping', 'Cats', 'Cochlea', 'Diagnostic Imaging', 'Humans', 'Models, Neurological', 'Neurons'] | 20,079,343 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['G17.035', 'L01.224.050'], ['B01.050'], ['A08.186.211.200.885.287.500.814.249', 'A08.186.211.200.885.287.500.863.297'], ['F02.463.593.071', 'G07.888.125'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The value of proteomics for the diagnosis of a platelet-related bleeding disorder. | Familial bleeding problems are frequently difficult to diagnose because currently used clinical tests cannot identify intracellular molecular defects of platelets. Using platelet proteomics, a comprehensive analytical tool, we diagnosed a family with severe bleeding problems of unknown origin with Quebec Platelet Disor... | ['Adenosine Diphosphate', 'Bleeding Time', 'Blood Platelets', 'Blood Proteins', 'Collagen', 'Cytoplasmic Granules', 'Enzyme Induction', 'Epinephrine', 'Female', 'Genes, Dominant', 'Hemorrhagic Disorders', 'Humans', 'Male', 'Pedigree', 'Platelet Aggregation', 'Proteomics', 'Quebec', 'Time Factors', 'Urokinase-Type Plasm... | 18,791,940 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['E01.370.225.625.625.100', 'E05.200.625.625.100', 'G09.188.087'], ['A11.118.188', 'A15.145.229.188'], ['D12.776.124'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['G05.308.32... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
A preclinical micro-computed tomography database including 3D whole body organ segmentations. | The gold-standard of preclinical micro-computed tomography (ìCT) data processing is still manual delineation of complete organs or regions by specialists. However, this method is time-consuming, error-prone, has limited reproducibility, and therefore is not suitable for large-scale data analysis. Unfortunately, robust ... | ['Animals', 'Databases, Factual', 'Image Processing, Computer-Assisted', 'Mice', 'Whole Body Imaging', 'X-Ray Microtomography'] | 30,561,432 | [['B01.050'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['L01.224.308'], ['B01.050.150.900.649.313.992.635.505.500'], ['E01.370.350.925', 'E05.979'], ['E01.370.350.700.810.810.900', 'E01.370.350.825.810.810.900']] | ['Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Differential diagnosis between undifferentiated tumor and thymoma by electron microscopy and immunohistochemical labelling. | This study of a particular case of tumor posed and resolved problems of differential diagnosis between an undifferentiated tumor and a thymoma by using electron microscopy in association with immunocytochemical methods. The first step was the distinction between an epithelial and a mesenchymal tumor, which was done by ... | ['Diagnosis, Differential', 'Epithelium', 'Fluorescent Antibody Technique', 'Humans', 'Immunohistochemistry', 'Male', 'Microscopy, Electron', 'Middle Aged', 'Thymic Factor, Circulating', 'Thymoma', 'Thymus Gland', 'Thymus Neoplasms'] | 2,678,036 | [['E01.171'], ['A10.272'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Determinants of ventricular refractory periods in children with congenital heart disease: effects of cycle length and age. | Ventricular effective refractory periods (ERP) and functional refractory periods (FRP) were determined by programmed ventricular extrastimulation in 53 pediatric patients with a spectrum of congenital heart disorders. Of these 63 children (ages 8 months to 18 years), 38 were preoperative, 17 had repair of their cardiac... | ['Action Potentials', 'Adolescent', 'Aging', 'Cardiac Catheterization', 'Child', 'Electrophysiology', 'Heart Defects, Congenital', 'Heart Ventricles', 'Humans', 'Infant'] | 7,246,417 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['M01.060.057'], ['G07.345.124'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['M01.060.406'], ['H01.158.344.528', 'H01.158.782.236'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], [... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
[Hirsutism with partial blockage of 3 beta OL hydroxysteroid dehydrogenase (author's transl)]. | The findings of normal testosterone, high normal delta 4 androstenedione, normal 17 OH progesterone and raised DHAs in a young girl of 16 who had regular periods and hirsutism made us think of block in 3 HSD. The 17 OH pregnenolone was raised. Dexamethasone (0.5 mg/24 h) treatment was effective for the hirsutism. | ['3-Hydroxysteroid Dehydrogenases', 'Adolescent', 'Dexamethasone', 'Female', 'Hirsutism', 'Humans'] | 6,944,379 | [['D08.811.682.047.436.350'], ['M01.060.057'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['C17.800.329.750', 'C23.888.971.468'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Isolation, purification and characterization of an extracellular L-asparaginase produced by a newly isolated Bacillus megaterium strain MG1 from the water bodies of Moraghat forest, Jalpaiguri, India. | An extracellular L-asparaginase was isolated and purified from Bacillus megaterium MG1 to apparent homogeneity. The purification procedure involved a combination of ammonium sulfate precipitation, ion-exchange chromatography, and gel filtration techniques, resulting in a purification factor of 31.52 fold with a specifi... | ['Asparaginase', 'Asparagine', 'Bacillus megaterium', 'Bacterial Proteins', 'Enzyme Activation', 'Enzyme Stability', 'Extracellular Space', 'Forests', 'Hydrogen-Ion Concentration', 'India', 'Kinetics', 'Molecular Weight', 'Phylogeny', 'Substrate Specificity', 'Temperature', 'Water Microbiology'] | 30,568,045 | [['D08.811.277.087.116'], ['D12.125.068.060', 'D12.125.095.165', 'D12.125.154.049'], ['B03.300.390.400.158.218.500', 'B03.353.500.100.218.500', 'B03.510.100.100.218.500', 'B03.510.415.400.158.218.500', 'B03.510.460.410.158.218.500'], ['D12.776.097'], ['G02.111.263', 'G03.328'], ['E05.916.360', 'G02.111.700.500'], ['A10... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Geographicals [Z]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
[Results of experimental animal studies on pervascular influences of indwelling intravasal catheters upon free tissue grafts (author's transl)]. | Free tissue grafting procedures were performed on sixteen experimental animals on the basis of previously described experiments (first communication). The objective of finding a suitable operating method for pervascular perfusion of epidermal grafts in animal experiments has been accomplished. At the same time, several... | ['Acid-Base Equilibrium', 'Animals', 'Body Temperature', 'Catheterization', 'Female', 'Perfusion', 'Skin Transplantation', 'Staining and Labeling', 'Swine'] | 91,280 | [['G02.111.007', 'G02.300.176', 'G03.030', 'G07.410.110', 'G09.188.050'], ['B01.050'], ['E01.370.600.875.374', 'G07.110'], ['E02.148', 'E05.157'], ['E05.680'], ['E02.095.147.725.700', 'E04.680.275.850', 'E04.936.580.700'], ['E01.370.225.500.620.670', 'E01.370.225.750.600.670', 'E05.200.500.620.670', 'E05.200.750.600.67... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metabolic function of grafted liver in rats. | We studied the metabolic variations in grafted livers at different times after transplant by measuring the hepatic energy and redox states. Five groups of rats were studied: control ungrafted Wistar (RT1y) rats (group 1), ungrafted Wistar rats with ligature of the hepatic artery (group 2), isografted Wistar rats (group... | ['Adenine Nucleotides', 'Animals', 'Glycolysis', 'Graft Survival', 'Liver', 'Liver Transplantation', 'Mitochondria, Liver', 'NAD', 'Rats', 'Rats, Inbred ACI', 'Rats, Inbred Strains', 'Transplantation, Homologous', 'Transplantation, Isogeneic'] | 3,061,077 | [['D03.633.100.759.646.138', 'D13.695.667.138', 'D13.695.827.068'], ['B01.050'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['G12.875.545.340'], ['A03.620'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['A11.284.430.214.190.875.564.461', 'A11.284.835.626.461'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Everolimus-treated renal transplant recipients have a more robust CMV-specific CD8+ T-cell response compared with cyclosporine- or mycophenolate-treated patients. | BACKGROUND: In renal transplant recipients, mammalian target of rapamycin (mTOR) inhibitors have been reported to protect against cytomegalovirus (CMV) disease. Here, we questioned whether mTOR inhibitors specifically influence human CMV-induced T-cell responses.METHODS: We studied renal transplant recipients treated w... | ['Adult', 'Aged', 'CD8-Positive T-Lymphocytes', 'Cyclosporine', 'Cytomegalovirus', 'Everolimus', 'Female', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Lymphocyte Activation', 'Male', 'Middle Aged', 'Mycophenolic Acid', 'Prednisolone', 'Sirolimus', 'TOR Serine-Threonine Kinases'] | 23,222,818 | [['M01.060.116'], ['M01.060.116.100'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['B04.280.382.150.150'], ['D02.540.505.760.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E02.870.... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Induction of intracellular superoxide radical formation by arachidonic acid and by polyunsaturated fatty acids in primary astrocytic cultures. | The effects of arachidonic acid and other polyunsaturated fatty acids (PUFAs) on both oxidative and metabolic perturbation were studied in primary cultures of rat cerebral cortical astrocytes. In the presence of 0.1 mM arachidonic acid, the rate of the reduction of nitroblue tetrazolium (NBT) to nitroblue formazan (NBF... | ['Animals', 'Arachidonic Acid', 'Arachidonic Acids', 'Astrocytes', 'Cells, Cultured', 'Fatty Acids, Unsaturated', 'Formazans', 'Lactates', 'Lactic Acid', 'Lipid Peroxides', 'Liposomes', 'Malondialdehyde', 'Nitroblue Tetrazolium', 'Oxidation-Reduction', 'Rats', 'Rats, Inbred Strains', 'Superoxide Dismutase', 'Superoxide... | 2,831,299 | [['B01.050'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['D10.251.355.255.100', 'D10.251.355.310.166'], ['A08.637.200', 'A11.650.200'], ['A11.251'], ['D10.251.355'], ['D02.172.600'], ['D02.241.511.459'], ['D02.241.511.459.450'], ['D01.248.497.158.685.750.637', 'D01.339.431.374.637', 'D01.650.550.750.600',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Costs and benefits of bevacizumab vial sharing for the treatment of retinal diseases. | BACKGROUND: Antiangiogenic therapy has proved to be an important therapeutic tool for many retinal vascular diseases; however, its availability is limited in developing countries. This study sought to describe the bevacizumab vial sharing process and to evaluate the impact of this repackaging system on the costs incurr... | ['Aged', 'Angiogenesis Inhibitors', 'Bevacizumab', 'Brazil', 'Cost-Benefit Analysis', 'Drug Costs', 'Female', 'Health Care Costs', 'Humans', 'Intravitreal Injections', 'Middle Aged', 'Retinal Diseases', 'Retrospective Studies'] | 31,510,981 | [['M01.060.116.100'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['D12.776.124.486.485.114.224.060.375', 'D12.776.124.790.651.114.224.060.438', 'D12.776.377.715.548.114.224.200.438'], ['Z01.107.757.176'], ['N03.219.151.125'], ['N03.219.151.400.350', 'N05.300.375.300'], ['N03.219.151.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The effects of ropivacaine hydrochloride on coagulation and fibrinolysis. An assessment using thromboelastography. | Amide local anaesthetics impair coagulation by inhibition of platelet function and enhanced fibrinolysis. The potential therefore exists that the presence of amide local anaesthetics in the epidural space could contribute to the therapeutic failure of an epidural autologous blood patch. Ropivacaine is an aminoamide loc... | ['Adult', 'Amides', 'Anesthetics, Local', 'Blood Coagulation', 'Dose-Response Relationship, Drug', 'Female', 'Fibrinolysis', 'Humans', 'Male', 'Middle Aged', 'Partial Thromboplastin Time', 'Prothrombin Time', 'Ropivacaine', 'Thrombelastography'] | 10,460,568 | [['M01.060.116'], ['D02.065'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['G09.188.390.150'], ['G07.690.773.875', 'G07.690.936.500'], ['G09.188.390.150.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.225.625.115.600', 'E05.200.625.115.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Incidence, etiology and risk factors associated with mortality of nosocomial candidemia in a tertiary care hospital in Istanbul, Turkey. | OBJECTIVE: The aim of this study was to determine the incidence, etiology and risk factors for mortality of patients with nosocomial candidemia.SUBJECTS AND METHODS: This observational study was performed at Haydarpasa Numune Training and Research Hospital, a tertiary care hospital with 750 beds, between the years 2004... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Candidemia', 'Cross Infection', 'Female', 'Hospital Bed Capacity, 500 and over', 'Hospitals, University', 'Humans', 'Incidence', 'Intensive Care Units', 'Length of Stay', 'Male', 'Middle Aged', 'Risk Factors', 'Sex Distribution', 'Socioeconomic F... | 20,881,414 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C01.150.703.160.175.500', 'C01.150.703.492.500.500', 'C01.757.360.150', 'C23.550.470.790.500.360.150'], ['C01.248', 'C23.550.291.875.500'], ['N02.278.306.472.300'], ['N02.278.020.300... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Phosphorylation of NF-KB1-p50 is involved in NF-kappa B activation and stable DNA binding. | We have previously shown that NF-kappa B/Rel family members are physically associated phosphoproteins, and p105 and p50 are hyperphosphorylated after NF-kappa B activation. In this report, we further studied the phosphorylation involved in NF-kappa B activation in Jurkat T cells responding to phorbol 12-myristate 13-ac... | ['Base Sequence', 'Binding Sites', 'Blotting, Western', 'Cell Line', 'Cell Nucleus', 'Cytoplasm', 'DNA', 'Humans', 'Macromolecular Substances', 'Molecular Sequence Data', 'NF-kappa B', 'NF-kappa B p50 Subunit', 'Oligonucleotide Probes', 'Phosphorylation', 'Phytohemagglutinins', 'Tetradecanoylphorbol Acetate'] | 7,982,908 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.214'], ['D13.444.308'], ['B01.050.150.900.649.313.988.4... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Comparative study of three methods to detect free plasma antiplatelet antibodies. | We have compared three techniques for the detection of plasma circulating antiplatelet antibodies, i.e., the platelet suspension immunofluorescence test (PSIFT), the platelet radioactive antiglobulin test (PRAT), and the monoclonal antibody immobilization of platelet antigens (MAIPA). Frozen plasma samples from patient... | ['Antibodies, Monoclonal', 'Antigens, Surface', 'Autoantibodies', 'Blood Platelets', 'Flow Cytometry', 'Fluorescent Antibody Technique, Indirect', 'Humans', 'Immunologic Techniques', 'Thrombocytopenia'] | 8,876,609 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['A11.118.188', 'A15.145.229.188'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dynamics of evolutionary radiation under ecological neutrality. | The most spectacular phenomenon of evolutionary biota is the explosive radiation that occurs in depauperate environments in which there are fewer competitors and predators, such as oceanic islands and crater lakes. Adaptation to divergent niches has been proposed as a major cause for this accelerated speciation. Here, ... | ['Biodiversity', 'Biological Evolution', 'Computer Simulation', 'Ecosystem', 'Extinction, Biological', 'Genetic Variation', 'Species Specificity', 'Time Factors'] | 27,297,287 | [['G16.500.275.157.049', 'N06.230.124.049'], ['G05.045', 'G16.075'], ['L01.224.160'], ['G16.500.275.157', 'N06.230.124'], ['G16.510'], ['G05.365'], ['G16.824'], ['G01.910.857']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Normal recovery of the stratum corneum barrier function following damage induced by tape stripping in patients with atopic dermatitis. | Patients with atopic dermatitis (AD) constantly inflict mechanical damage to their skin by scratching induced by pruritus. On excoriated lesions of the cheek we found exceedingly high levels of transepidermal water loss (TEWL) as compared to those in the normal skin of healthy subjects. However, it is not clear whether... | ['Adult', 'Cell Membrane Permeability', 'Dermatitis, Atopic', 'Epidermis', 'Face', 'Female', 'Humans', 'Male', 'Water Loss, Insensible', 'Wound Healing'] | 9,217,838 | [['M01.060.116'], ['G03.143.335', 'G04.175'], ['C16.320.850.210', 'C17.800.174.193', 'C17.800.815.193', 'C17.800.827.210', 'C20.543.480.343'], ['A10.272.497', 'A17.815.250'], ['A01.456.505'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.635.500.750', 'G03.615.500.750', 'G07.410.810.500.750'], ['G16.762.89... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Surgical treatment of recurrent parathyroid carcinoma with invasion of the upper aerodigestive tract]. | OBJECTIVE: To evaluate the factors contributed to the recurrence of parathyroid carcinoma with the invasion of the upper aerodigestive tract and the outcomes of reoperation.METHODS: Six cases reviewed, in which the age ranged from 32 to 79 years old. The initial diagnoses and surgical procedures, the sites and surgical... | ['Adult', 'Aged', 'Female', 'Gastrointestinal Tract', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Parathyroid Neoplasms', 'Reoperation', 'Respiratory System', 'Retrospective Studies'] | 22,335,975 | [['M01.060.116'], ['M01.060.116.100'], ['A03.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.655', 'C23.550.727.655'], ['C04.588.322.525', 'C04.588.443.680', 'C19.344.525', 'C19.642.713'], ['E04.690'], ['A04'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.33... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Use of video eyewear to manage distress in children during restorative dental treatment. | PURPOSE: The purpose of this study was to evaluate the effectiveness of video eyewear in reducing disruptive behavior in a typical pediatric dental population during restorative treatment appointments.METHODS: One hundred twenty-eight 4- to 16-year-olds were recruited from a continuous sample of patients seen in an ur... | ['Adolescent', 'Attention', 'Child', 'Child Behavior', 'Child, Preschool', 'Dental Anxiety', 'Dental Restoration, Permanent', 'Eyeglasses', 'Humans', 'Video Recording'] | 23,211,912 | [['M01.060.057'], ['F02.830.104.214'], ['M01.060.406'], ['F01.145.179'], ['M01.060.406.448'], ['F01.470.132.300'], ['E06.323.428', 'E06.780.346.737', 'E07.695.190.190'], ['E07.632.500.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.280.960']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
T cell receptor ligation triggers novel nonapoptotic cell death pathways that are Fas-independent or Fas-dependent. | Short-term culture of activated T cells with IL-2 renders them highly susceptible to apoptotic death triggered by TCR cross-linking. Activation-induced apoptosis is contingent upon caspase activation and this is mediated primarily by Fas/Fas ligand (FasL) interactions that, in turn, are optimized by p38 mitogen-activat... | ['Animals', 'Apoptosis', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Caspases', 'Cell Death', 'Fas Ligand Protein', 'In Vitro Techniques', 'Lymphocyte Activation', 'Membrane Glycoproteins', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C3H', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Mice, Mutant Strains'... | 12,444,127 | [['B01.050'], ['G04.146.954.035'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', '... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Human B cell proliferation is stimulated by interleukin 2. | The proliferation of human B cells was studied for response to interleukin 2 (IL-2) produced in Escherichia coli using recombinant DNA technology. The IL-2 was found to be an homogenous preparation by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting using the anti-IL-2 monoclonal... | ['Antibodies, Anti-Idiotypic', 'B-Lymphocytes', 'Humans', 'Immunoglobulin M', 'In Vitro Techniques', 'Interleukin-2', 'Lymphocyte Activation'] | 3,872,838 | [['D12.776.124.486.485.114.071', 'D12.776.124.790.651.114.071', 'D12.776.377.715.548.114.071'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.574', 'D12.776.124.790.6... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Risk of lung cancer and past use of cannabis in Tunisia. | The association between the use of cannabis and the risk of lung cancer is unclear. A hospital-based case-control study was conducted among men in Tunisia and included 149 incident lung cancer cases and 188 controls. Tobacco smoking was significantly associated with an increased risk of lung cancer with odds ratios inc... | ['Adult', 'Age Distribution', 'Biopsy, Needle', 'Cannabis', 'Case-Control Studies', 'Cohort Studies', 'Confidence Intervals', 'Humans', 'Immunohistochemistry', 'Incidence', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Odds Ratio', 'Probability', 'Risk Assessment', 'Smoking', 'Survival Analysis', 'Time ... | 17,409,920 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['B01.650.940.800.575.912.250.859.937.055.500'], ['E05.318.37... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Geographica... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Discussion on early clinical drug development in the target population with respect to the field of reproductive endocrinology. | The study populations taking part in early clinical drug development of reproductive endocrine treatments are discussed. After having compared subjects in phase I studies with subsequent target populations, the question was posed as to whether the inclusion of the later target population could accelerate the developmen... | ['Adult', 'Clinical Trials, Phase I as Topic', 'Contraceptives, Oral', 'Drug Evaluation', 'Endocrinology', 'Female', 'Hormone Replacement Therapy', 'Humans', 'Middle Aged', 'Patient Selection'] | 9,849,748 | [['M01.060.116'], ['E05.318.372.250.250.200', 'N05.715.360.330.250.250.200', 'N06.850.520.450.250.250.200'], ['D27.505.696.875.360.276.210', 'D27.505.954.705.360.276.210'], ['E05.290.625', 'E05.337.425'], ['H01.158.782.323', 'H02.403.429.323'], ['E02.319.452'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Treatment of Parkinson disease with C17.2 neural stem cells overexpressing NURR1 with a recombined republic-deficit adenovirus containing the NURR1 gene. | To study the potential benefit of the NURR1 gene in Parkinson's disease (PD), we constructed a recombinant republic-deficit adenovirus containing the NURR1 gene (Ad-NURR1) and expressed it in transplanted neural stem cells (NSC). Ad-NURR1 was constructed, and NURR1 mRNA and protein expression were identified by in situ... | ['Adenoviridae', 'Adrenergic Agents', 'Animals', 'Behavior, Animal', 'Cell Differentiation', 'Cell Line, Transformed', 'DNA-Binding Proteins', 'Disease Models, Animal', 'Genetic Therapy', 'Humans', 'Microscopy, Electron, Scanning', 'Neurons', 'Nuclear Receptor Subfamily 4, Group A, Member 2', 'Oxidopamine', 'Parkinson ... | 17,879,263 | [['B04.280.030'], ['D27.505.519.625.050', 'D27.505.696.577.050'], ['B01.050'], ['F01.145.113'], ['G04.152'], ['A11.251.210.172'], ['D12.776.260'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E02.095.301', 'E05.393.420.301'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402.541', 'E05.595.402.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hydrous manganese oxide doped gel probe sampler for measuring in situ reductive dissolution rates. 2. Field deployment. | In situ rates of reductive dissolution in submerged shoreline sediments at Lake Tegel (Berlin, Germany) were measured with a novel hydrous manganese (Mn) oxide-doped gel probe sampler in concert with equilibrium gel probe and sequential extraction measurements. Rates were low in the top 8 cm, then showed a peak from 8 ... | ['Manganese Compounds', 'Oxidation-Reduction', 'Oxides', 'Solubility', 'Water Pollutants, Chemical'] | 20,039,732 | [['D01.530'], ['G02.700', 'G03.295.531'], ['D01.248.497.158.685', 'D01.650.550'], ['G02.805'], ['D27.888.284.903.655']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Purification of the O antigen of Bacteroides fragilis ss. fragilis NCTC 9343 from phenol-water extracts by gel filtration and chromatography on deae-cellulose and hydroxylapatite. | O antigen extracted from whole cells of Bacteroides fragilis ss. fragilis NCTC 9343 with 45 per cent aqueous phenol has been purified by gel filtration and chromatography. First, the water phase was treated with RNase and DNase and passed through a column of agarose. The chromatographic procedures included ion exchange... | ['Antigens, Bacterial', 'Bacteroides fragilis', 'Chromatography, DEAE-Cellulose', 'Chromatography, Gel', 'Deoxyribonucleases', 'Hemagglutination Inhibition Tests', 'Hydroxyapatites', 'Phenols', 'Ribonucleases'] | 961,434 | [['D23.050.161'], ['B03.440.080.094.152.400', 'B03.440.425.410.194.152.400'], ['E05.196.181.400.383.349'], ['E05.196.181.400.250'], ['D08.811.277.352.335'], ['E01.370.225.812.735.370', 'E05.200.812.735.370', 'E05.478.594.760.370'], ['D01.029.260.700.675.374.075.025.300', 'D01.146.360.050.300', 'D01.578.122.477', 'D01.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Risk of ischemic stroke after new-onset atrial fibrillation in patients with hyperthyroidism. | BACKGROUND: Hyperthyroidism is one of the most common reversible causes of atrial fibrillation (AF); nevertheless, the risk of ischemic stroke in patients with hyperthyroidism who present with new-onset AF is unclear.OBJECTIVE: This study sought to investigate the clinical outcome of hyperthyroidism-induced AF with reg... | ['Adult', 'Atrial Fibrillation', 'Brain Ischemia', 'Case-Control Studies', 'Female', 'Humans', 'Hyperthyroidism', 'Incidence', 'Male', 'Middle Aged', 'Proportional Hazards Models', 'Prospective Studies', 'Risk'] | 19,187,905 | [['M01.060.116'], ['C14.280.067.198', 'C23.550.073.198'], ['C10.228.140.300.150', 'C14.907.253.092'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.874.397'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.5... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transformation products of 1,1-dimethylhydrazine and their distribution in soils of fall places of rocket carriers in Central Kazakhstan. | In our research, three fall places of first stages of Proton rockets have been studied for the presence and distribution of transformation products of 1,1-dimethylhydrazine (1,1-DMH). Results of identification of transformation products of 1,1-DMH in real soil samples polluted due to rocket fuel spills allowed to detec... | ['Dimethylhydrazines', 'Environmental Monitoring', 'Gas Chromatography-Mass Spectrometry', 'Kazakhstan', 'Soil Pollutants', 'Solid Phase Microextraction'] | 22,554,529 | [['D02.442.600.400'], ['N06.850.460.350.080', 'N06.850.780.375'], ['E05.196.181.349.500', 'E05.196.566.500'], ['Z01.252.100.420', 'Z01.542.931.440', 'Z01.586.950.440'], ['D27.888.284.756'], ['E05.196.155.800.500']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits. | Sildenafil citrate (Viagra) is the pharmacological agent used to treat erectile dysfunction in men. Because this drug has a vasodilatory effect, we hypothesized that such an action may induce a preconditioning-like cardioprotective effect via opening of mitochondrial ATP-sensitive K (K(ATP)) channels. Rabbits were trea... | ['Administration, Oral', 'Animals', 'Cardiotonic Agents', 'Injections, Intravenous', 'Male', 'Membrane Proteins', 'Myocardial Infarction', 'Myocardial Reperfusion Injury', 'Piperazines', 'Potassium Channels', 'Purines', 'Rabbits', 'Sildenafil Citrate', 'Sulfones', 'Vasodilator Agents'] | 12,181,158 | [['E02.319.267.100'], ['B01.050'], ['D27.505.954.411.222', 'D27.720.799.080'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['D12.776.543'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['C14.280.238.615', 'C14.280.647.625', 'C14.907.585.625', 'C14.907.725.600', 'C23.550.767.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Influence of PP2A activator on proliferation of HL-60 cells and analysis of PP2A activity changes in patients with acute myeloid leukemia]. | In order to investigate the effect of PP2A activator and PP2A inhibitor on proliferation of HL-60 cells and analyze the changes of PP2A activity in patients with acute myeloid leukemia (AML), HL-60 cells were treated with FTY720 alone or in combination with okadaic acid (OA) for 24 hours in culture. Cell proliferation ... | ['Adult', 'Aged', 'Apoptosis', 'Case-Control Studies', 'Cell Proliferation', 'Enzyme Activators', 'Enzyme Inhibitors', 'Female', 'Fingolimod Hydrochloride', 'HL-60 Cells', 'Humans', 'Leukemia, Myeloid, Acute', 'Male', 'Middle Aged', 'Okadaic Acid', 'Propylene Glycols', 'Protein Phosphatase 2', 'Sphingosine', 'Young Adu... | 21,729,530 | [['M01.060.116'], ['M01.060.116.100'], ['G04.146.954.035'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G04.161.750', 'G07.345.249.410.750'], ['D27.505.519.374'], ['D27.505.519.389'], ['D02.033.100.700.350', 'D02.033.455.706.431', 'D02.092.063.700.350'], ['A11.251.210.190.465', 'A11... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Heart rate variability after coronary artery bypass graft surgery: a prospective 3-year follow-up study. | BACKGROUND: Autonomic heart rate control is impaired after CABG. The aim of this study was to establish the temporal pattern of change in the decrease of HRV observed after CABG.METHODS AND RESULTS: Twelve patients with coronary artery disease were assessed with 24-hour Holter recordings 2 days before CABG and 1 week, ... | ['Adult', 'Age Distribution', 'Aged', 'Bradycardia', 'Case-Control Studies', 'Coronary Artery Bypass', 'Coronary Disease', 'Electrocardiography, Ambulatory', 'Female', 'Heart Rate', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Postoperative Period', 'Preoperative Care', 'Prospective Studies', 'Reference Values', 'Ris... | 12,167,187 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['C14.280.067.319', 'C23.550.073.300'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['C14.280.647.250', 'C14.907.585.250... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Post-dilution hemodiafiltration with a heparin-grafted polyacrylonitrile membrane. | The aim of this multicenter, prospective study was to explore the possibility of carrying out routine sessions of post-dilution hemodiafiltration with a polyacrylonitrile membrane grafted with heparin (HeprAN) and reduced anticoagulation. Forty-four patients from eight centers were included in the study and treated by ... | ['Acrylic Resins', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Fibrinolytic Agents', 'Hemodiafiltration', 'Heparin, Low-Molecular-Weight', 'Humans', 'Italy', 'Kidney Failure, Chronic', 'Male', 'Membranes, Artificial', 'Middle Aged', 'Prospective Studies', 'Treatment Outcome', 'Young Adult'] | 25,257,219 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['E02.870.300.200', 'E02.912.800.200', 'E04.292.471.350'], ['D09.698.373.400.300'], ['B01.050.150.900.649.... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Selective Antiproliferative Withanolides from Species in the Genera Eriolarynx and Deprea. | Four new withanolides (2-5), together with 4â,7â,20-trihydroxy-1-oxowitha-2,5,24-trienolide (1), were isolated from the aerial parts of Eriolarynx iochromoides. The antiproliferative activity of all compounds purified from E. iochromoides together with four withaphysalins and four physangulidines isolated previously fr... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Antineoplastic Agents, Phytogenic', 'Cell Line, Tumor', 'Cell Proliferation', 'Drug Screening Assays, Antitumor', 'Humans', 'Molecular Structure', 'Nuclear Magnetic Resonance, Biomolecular', 'Plant Components, Aerial', 'Solanaceae', 'Structure-Activity Relati... | 31,070,367 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['D27.505.954.248.179'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fluorescent sensing of mercury(II) based on formation of catalytic gold nanoparticles. | A fluorescence assay for the highly sensitive and selective detection of Hg(2+) using a gold nanoparticle (AuNP)-based probe was proposed. The assay was based on the formation of Hg-Au alloys, which accelerated the oxidization of o-phenylenediamine by dissolved oxygen to produce 2,3-diaminophenazine, a fluorescent prod... | ['Catalysis', 'Gold', 'Mercury', 'Metal Nanoparticles', 'Spectrometry, Fluorescence'] | 23,722,274 | [['G02.130'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['J01.637.512.600.500'], ['E05.196.712.516.600.676', 'E05.196.867.726']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen. | BACKGROUND: Mycobacterium tuberculosis (Mtb) becomes dormant and phenotypically drug resistant when it encounters multiple stresses within the host. Inability of currently available drugs to kill latent Mtb is a major impediment to curing and possibly eradicating tuberculosis (TB). Most in vitro dormancy models, using ... | ['Cluster Analysis', 'Coloring Agents', 'Down-Regulation', 'Drug Resistance, Multiple, Bacterial', 'Gene Expression Regulation', 'Gene Expression Regulation, Bacterial', 'Genes, Bacterial', 'Hydrogen-Ion Concentration', 'Lipids', 'Microbial Sensitivity Tests', 'Mycobacterium tuberculosis', 'Oxazines', 'Phenotype', 'Rev... | 19,562,030 | [['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['D27.720.233'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['G05.308'], ['G05.308.300'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
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