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[From Alma-Ata to the digital citizen: towards a digital primary health care in Peru]. | The countries of the Region of the Americas Numerous have experienced many changes since the Declaration of AlmaAta in 1978, such as globalization, new epidemiologic and demographic profiles, and the information and communication technology revolution. Nevertheless, the primary health care models in many countries of t... | ['Congresses as Topic', 'Forecasting', 'Global Health', 'International Cooperation', 'Kazakhstan', 'Medical Informatics', 'Peru', 'Primary Health Care'] | 30,726,422 | [['N03.540.199'], ['I01.320'], ['H02.403.371', 'N01.400.337'], ['I01.615.500'], ['Z01.252.100.420', 'Z01.542.931.440', 'Z01.586.950.440'], ['L01.313.500'], ['Z01.107.757.702'], ['N04.590.233.727']] | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Inhibitors of protein synthesis inhibit both La Crosse virus S-mRNA and S genome syntheses in vivo. | The effect of drugs such as puromycin and cycloheximide, which inhibit protein synthesis, on the accumulation of La Crosse virus S genome RNAs in vivo has been examined. We have found that if these drugs are added to the cultures before infection, minuscule amounts of S-mRNA can be detected late in infection. Genome re... | ['Anisomycin', 'Bunyaviridae', 'Cycloheximide', 'Encephalitis Virus, California', 'Genes, Viral', 'Pactamycin', 'Protein Biosynthesis', 'Puromycin', 'RNA, Messenger', 'RNA, Viral', 'Trichodermin'] | 3,751,285 | [['D03.383.773.050'], ['B04.820.480.750'], ['D03.383.621.808.240'], ['B04.820.230.100', 'B04.820.480.750.640.300'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['D02.241.223.100.300.450', 'D02.241.511.390.450', 'D02.455.426.559.389.127.281.450', 'D02.455.426.559.389.657.410.45... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Idiotypic analysis of hybridoma antibodies to branched synthetic polymer (Tyr, Glu)-Ala-Lys: idiotypic relationship with antibodies to linear random polymer (Glu60, Ala30, Tyr10). | The expression of three anti-GAT idiotypes, CGAT, Gte, and GA-1, on 17 C57BL/10 and four C3H.SW hybridoma anti-(T,G)-A--L antibodies was analyzed. These hybridoma anti-(T,G)-A--L antibodies exhibited two patterns of fine antigen binding specificity. The majority of the hybridoma antibodies bound the (T,G)-A--L, GT, and... | ['Animals', 'Binding Sites, Antibody', 'Epitopes', 'Guinea Pigs', 'Hybridomas', 'Immune Sera', 'Immunoglobulin Idiotypes', 'Mice', 'Mice, Inbred C3H', 'Mice, Inbred DBA', 'Mice, Inbred Strains', 'Peptides', 'Polymers', 'Rabbits'] | 6,172,496 | [['B01.050'], ['G02.111.570.060.425.079', 'G02.111.570.120.408', 'G12.122.232', 'G12.125'], ['D23.050.550'], ['B01.050.150.900.649.313.992.550'], ['A11.251.353.485', 'A11.251.600.485'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.573', 'D12.776.377.715.548.114.573', 'D20.215.401'], [... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor. | Previously, we showed that the expression of potassium channel tetramerization domain-containing 12 (KCTD12), which was discovered by a proteomics approach, is associated with high-risk behavior of gastrointestinal stromal tumors (GISTs). Here, we examined the distribution and expression of this protein by immunostaini... | ['Aged', 'Biomarkers, Tumor', 'Endothelium, Vascular', 'Female', 'Gastrointestinal Neoplasms', 'Gastrointestinal Stromal Tumors', 'Humans', 'Interstitial Cells of Cajal', 'Japan', 'Male', 'Neoplasm Recurrence, Local', 'Neurons', 'Prognosis', 'Proteins', 'Purkinje Cells', 'Soft Tissue Neoplasms', 'Survival Rate'] | 23,290,008 | [['M01.060.116.100'], ['D23.101.140'], ['A07.015.700.500', 'A10.272.491.355'], ['C04.588.274.476', 'C06.301.371', 'C06.405.249'], ['C04.557.450.565.370', 'C06.301.371.308', 'C06.405.249.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.620.124'], ['Z01.252.474.463', 'Z01.639.595'], ['C04.697.655', 'C23.550.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Endothelial nitric oxide synthase gene intron 4 polymorphism in type 2 diabetes mellitus. | INTRODUCTION: Endothelial nitric oxide synthase (ecNOS) is a key regulator of vascular nitric oxide production. Polymorphism in intron 4 of the ecNOS gene is implicated in cardiovascular and renal diseases. We investigated a potential involvement of this polymorphism in the development of type 2 diabetes mellitus and i... | ['Adult', 'Aged', 'Alleles', 'Base Sequence', 'Case-Control Studies', 'DNA, Complementary', 'Diabetes Mellitus, Type 2', 'Diabetic Angiopathies', 'Female', 'Gene Frequency', 'Humans', 'Introns', 'Male', 'Middle Aged', 'Nitric Oxide Synthase', 'Nitric Oxide Synthase Type III', 'Polymorphism, Genetic'] | 14,580,231 | [['M01.060.116'], ['M01.060.116.100'], ['G05.360.340.024.340.030'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['C18.452.394.750.149', 'C19.246.30... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Relationship of genotype rather than race to hepatitis B virus pathogenicity: a study of Japanese and Solomon Islanders. | The aim of this study was to determine the predominant hepatitis B virus (HBV) genotype in the Solomon Islands and determine if there is any racial correlation between genotype and hepatitis B e antigen (HBeAg) production in Japanese and Melanesian individuals. A total of 403 serum samples from 206 Melanesian HBV carri... | ['Adolescent', 'Adult', 'Age Factors', 'Amino Acid Sequence', 'Asian Continental Ancestry Group', 'Female', 'Genotype', 'Hepatitis B', 'Hepatitis B Surface Antigens', 'Hepatitis B virus', 'Humans', 'Male', 'Melanesia', 'Molecular Sequence Data', 'Protein Precursors'] | 15,155,994 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['G02.111.570.060', 'L01.453.245.667.060'], ['M01.686.508.200'], ['G05.380'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D23.050.327.495.500.475'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['B0... | ['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Effect of thyroxine administration to the mother on postnatal radioiodine uptake by the thyroid of partially thyroidectomized rats. | The experiment was carried out on 35 litters of infant rats aged 4-17 days. The animals in each litter were always divided into two groups: control (sham operation) and experimental (hemithyroidectomy). Starting with the day on which the young were operated on, the mothers received daily subcutaneous injections of eith... | ['Animals', 'Animals, Newborn', 'Female', 'Iodine Radioisotopes', 'Maternal-Fetal Exchange', 'Pregnancy', 'Rats', 'Thyroid Gland', 'Thyroidectomy', 'Thyroxine'] | 128,011 | [['B01.050'], ['B01.050.050.282'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['G08.686.784.769.455'], ['G08.686.784.769'], ['B01.050.150.900.649.313.992.635.505.700'], ['A06.300.900'], ['E04.270.856'], ['D06.472.931.812', 'D12.125.072.050.767']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of amide replacements in CCR5 antagonists as a means to increase intrinsic permeability. Part 2: SAR optimization and pharmacokinetic profile of a homologous azacyle series. | Replacement of a secondary amide with a piperidine or azetidine moiety in a series of CCR5 antagonists led to the discovery of compounds with increased intrinsic permeability. This effort led to the identification of a potent CCR5 antagonist which exhibited an improved in vivo pharmacokinetic profile. | ['Amides', 'Aza Compounds', 'CCR5 Receptor Antagonists', 'Structure-Activity Relationship'] | 20,855,212 | [['D02.065'], ['D02.145'], ['D27.505.519.275', 'D27.505.954.122.388.077.088.104'], ['G02.111.830', 'G07.690.773.997']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Streptozotocin diabetes: a glucoreceptor dysfunction affecting D cells as well as B and A cells. | Somatostatin release from the isolated pancreas of 3 normal and 6 streptozotocin diabetic dogs has been measured in response to various stimuli to determine whether abnormalities in somatostatin release are present in the diabetic pancreas. Simultaneous measurement of glucagon secretion was also made. In the pancreas f... | ['Animals', 'Arginine', 'Calcium', 'Diabetes Mellitus, Experimental', 'Dogs', 'Glucagon', 'Glucose', 'Insulin', 'Isoproterenol', 'Male', 'Pancreas', 'Somatostatin'] | 395,006 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid recovery of in vivo prostacyclin formation after inhibition by aspirin. Evidence from measurements of the major urinary metabolite of prostacyclin by GC-MS. | The effect of aspirin on the in vivo formation of prostacyclin and thromboxane A2 in normal healthy individuals was studied by measuring the urinary excretion of 2,3-dinor-6-keto-PGF1 alpha and 2,3-dinor-TxB2 by gas chromatography-mass spectrometry. Administration of 500 mg aspirin twice daily caused a sustained reduct... | ['6-Ketoprostaglandin F1 alpha', 'Adult', 'Aspirin', 'Epoprostenol', 'Female', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Male', 'Prostaglandin Antagonists', 'Thromboxane B2', 'Time Factors'] | 3,519,239 | [['D10.251.355.255.550.400.350', 'D10.251.355.325.450', 'D23.469.050.175.725.400.350'], ['M01.060.116'], ['D02.455.426.559.389.657.410.595.176'], ['D10.251.355.255.550.550.500', 'D23.469.050.175.725.550.500'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.347.710', '... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Educating tomorrow's doctors. | Universities and medical schools must leave their cloistered environment. The time has come for them to venture out into the world and grapple with the problems of society, taking actual responsibility for the health of their local populations. And medical students should be educated in the ideals and practicalities of... | ['Academic Medical Centers', 'Clinical Competence', 'Curriculum', 'Education, Medical', 'Ethics, Medical', 'Forecasting', 'Health Services Needs and Demand', 'Humans', "Physician's Role", 'Social Change', 'Social Values', 'Teaching'] | 8,397,729 | [['N02.278.020'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.158'], ['I02.358.399'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['I01.320'], ['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.316.616.625.600'], ['I01.076.201.450.776', 'I01.880.853.4... | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Chemoprophylaxis of Dirofilaria immitis (Leidy 1856) infection at a high challenge environment. | BACKGROUND: The frequency of canine heartworm infection in the state of Rio de Janeiro, Brazil was high before chemoprophylactic treatment was available, with one of the highest rates of infection (52.5 %) found among dogs living on the eastern shore of the state. Following the launch of a chemoprophylactic product, th... | ['Administration, Topical', 'Animals', 'Anthelmintics', 'Brazil', 'Chemoprevention', 'Dirofilaria immitis', 'Dirofilariasis', 'Dog Diseases', 'Dogs', 'Drug Therapy, Combination', 'Environment', 'Female', 'Imidazoles', 'Ivermectin', 'Lactones', 'Macrolides', 'Male', 'Microfilariae', 'Neonicotinoids', 'Nitro Compounds'] | 26,459,036 | [['E02.319.267.120'], ['B01.050'], ['D27.505.954.122.250.075'], ['Z01.107.757.176'], ['E02.319.162'], ['B01.050.500.500.294.400.937.463.230.300'], ['C01.610.335.349.320', 'C01.610.335.508.700.750.361.290', 'C01.610.701.377.320', 'C22.674.377.320'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['E02.319.310... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The Relation Between Endothelial Nitric Oxide Synthase Polymorphisms and Normal Tension Glaucoma. | PURPOSE: We investigated whether polymorphisms of the endothelial NO synthase (eNOS) gene are associated with normal tension glaucoma (NTG). We also investigated whether the eNOS polymorphisms are associated with NTG subgroups [NTG with and without optic disc hemorrhage (DH)].METHODS: A total of 251 patients with NTG a... | ['Adult', 'Aged', 'Alleles', 'Female', 'Genotype', 'Healthy Volunteers', 'Humans', 'Intraocular Pressure', 'Low Tension Glaucoma', 'Male', 'Middle Aged', 'Nitric Oxide Synthase Type III', 'Optic Disk', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length', 'Polymorphism, Single Nucleotide', 'Retinal ... | 28,777,225 | [['M01.060.116'], ['M01.060.116.100'], ['G05.360.340.024.340.030'], ['G05.380'], ['M01.774.500', 'M01.955.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['C11.525.381.703', 'C11.640.225'], ['M01.060.116.630'], ['D08.811.682.664.500.772.750'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['E05.3... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. | In vertebrates, primary sex determination refers to the decision within a bipotential organ precursor to differentiate as a testis or ovary. Bifurcation of organ fate begins between embryonic day (E) 11.0-E12.0 in mice and likely involves a dynamic transcription network that is poorly understood. To elucidate the first... | ['Adaptor Proteins, Signal Transducing', 'Animals', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation, Developmental', 'Gene Regulatory Networks', 'Gonads', 'LIM Domain Proteins', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Ovary', 'RNA, Small Interfering', 'Sex Determination Processes', 'Testis'] | 23,874,228 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['E05.393.332'], ['G05.308.310'], ['G05.360.080.689.360'], ['A05.360.576', 'A06.300.312'], ['D12.776.512'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['A05.360.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus. | FKBP, an 11.8 kD intracellular protein that binds the immunosuppressants FK506 (Kd = 0.4 nM) and rapamycin (Kd = 0.2 nM) with high affinity, was purified to homogeneity from calf thymus. The complete amino acid sequence has been determined by automated Edman degradation of the intact molecule and overlapping fragments ... | ['Amino Acid Sequence', 'Animals', 'Carrier Proteins', 'Cattle', 'Cyanogen Bromide', 'Immunosuppressive Agents', 'Molecular Sequence Data', 'Molecular Structure', 'Peptide Fragments', 'Polyenes', 'Sirolimus', 'Tacrolimus', 'Tacrolimus Binding Proteins', 'Thymus Gland', 'Trypsin'] | 1,718,307 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.157'], ['B01.050.150.900.649.313.500.380.271'], ['D01.139.300.050.100', 'D01.625.175'], ['D27.505.696.477.656'], ['L01.453.245.667'], ['G02.111.570', 'G02.466'], ['D12.644.541'], ['D02.455.326.271.665'], ['D02.540.505.760'], ['D02.540.505.810'], ['D08.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Endothelin-1 in hypertension in the baroreflex-intact SHR: a role independent from vasopressin release. | This study sought to identify whether central endothelin (ET) receptor activation contributes to the elevated pressure in spontaneously hypertensive rats (SHR) and whether an ET-stimulated vasopressin (AVP) release mediates the increased pressure. In Wistar Kyoto (WKY) rats, intracerebroventricular ET-1 induced a dose-... | ['Animals', 'Arginine Vasopressin', 'Baroreflex', 'Blood Pressure', 'Denervation', 'Endothelin-1', 'Heart Rate', 'Hypertension', 'Male', 'Rats', 'Rats, Inbred SHR', 'Rats, Inbred WKY', 'Receptors, Vasopressin', 'Sinus of Valsalva'] | 10,893,318 | [['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['G09.330.380.057', 'G11.561.731.063'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E04.525.210'], ['D12.644.276.400.225', 'D12.776.467.400.225', 'D23.529.400.225'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early childhood lead exposure and the persistence of educational consequences into adolescence. | BACKGROUND: There is consensus that early childhood lead exposure causes adverse cognitive and behavioral effects, even at blood lead levels (BLL) below 5 ìg/dL. What has not been established is to what extent the effects of childhood lead exposure persist across grades.OBJECTIVE: To measure the effects of early childh... | ['Academic Performance', 'Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Environmental Exposure', 'Female', 'Humans', 'Lead', 'Lead Poisoning', 'Male', 'North Carolina', 'Schools', 'Young Adult'] | 31,473,504 | [['I02.399.136'], ['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['N06.850.460.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.435', 'D01.552.544.435'], ['C25.723.522.750'], ['Z01.107.567.875.075.475', 'Z01.107.567.875.750.530'], ['I02.783', 'J03.832'], ['M01.060.116.815']... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus. | AIM: Staphylococcus aureus evades host defense through releasing several virulence proteins, such as chemotaxis inhibitory protein of staphylococcus aureus (CHIPS). It has been shown that extracellular N terminus of C5a receptor (C5aR) forms the binding domain for CHIPS, and tyrosine sulfation is emerging as a key fact... | ['Bacterial Proteins', 'Cell Line, Transformed', 'HEK293 Cells', 'Humans', 'Protein Binding', 'Protein Structure, Tertiary', 'Receptor, Anaphylatoxin C5a', 'Receptors, Complement', 'Staphylococcus aureus', 'Tyrosine'] | 21,706,042 | [['D12.776.097'], ['A11.251.210.172'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709.610'], ['D12.776.543.750.695.024', 'D12.776.543.750.705.833.550'], ['D12.776.543.750.705.833'], ['B03.300.390.400.800.750.100', 'B03.353.500.7... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Expression of Bcl-2 and Fas and apoptosis of T lymphocyte in the peripheral blood of patients with end-stage renal diseases]. | OBJECTIVE: To investigate the expression of Bcl-2 and Fas and the apoptosis of T lymphocyte in the peripheral blood of patients with end-stage renal diseases; and to test the impact of various dialysis membranes on the apoptosis of T lymphocyte.METHODS: T lymphocyte was cultured with the stimulation of Phytohemagglutin... | ['Aged', 'Apoptosis', 'Fas Ligand Protein', 'Female', 'Humans', 'Immunohistochemistry', 'Kidney Failure, Chronic', 'Male', 'Middle Aged', 'Proto-Oncogene Proteins c-bcl-2', 'Renal Dialysis', 'T-Lymphocytes'] | 18,575,326 | [['M01.060.116.100'], ['G04.146.954.035'], ['D12.644.276.374.750.249', 'D12.776.395.550.312', 'D12.776.467.374.750.249', 'D12.776.543.550.312', 'D23.529.374.750.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Inhibition of EZH2 induces NK cell-mediated differentiation and death in muscle-invasive bladder cancer. | Lysine-specific demethylase 6A (KDM6A) and members of the Switch/Sucrose Non-Fermentable (SWI/SNF) family are known to counteract the activity of Enhancer of Zeste Homolog 2 (EZH2), which is often overexpressed and is associated with poor prognosis in muscle-invasive bladder cancer. Here we provide evidence that altera... | ['Animals', 'Cell Death', 'Cell Differentiation', 'Cell Line, Tumor', 'Cisplatin', 'Enhancer of Zeste Homolog 2 Protein', 'Humans', 'Killer Cells, Natural', 'Mice', 'Mice, Nude', 'Urinary Bladder Neoplasms', 'Xenograft Model Antitumor Assays'] | 30,692,641 | [['B01.050'], ['G04.146'], ['G04.152'], ['A11.251.210.190', 'A11.251.860.180'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D05.500.781.750.250', 'D08.811.913.555.500.800.200.500.500.500', 'D12.776.660.235.600.200.250', 'D12.776.664.235.800.200.250', 'D12.776.930.780.890.200.250'], ['B01.050.150.900.649.313.988.40... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Polysaccharide fractions from Fortunella margarita affect proliferation of Bifidobacterium adolescentis ATCC 15703 and undergo structural changes following fermentation. | In this study, the relationships between the proliferation effect of polysaccharide fractions from the citrus shrub Fortunella margarita on Bifidobacterium adolescentis ATCC 15703 and their resulting structural changes were investigated. Four polysaccharide fractions, FP20, FP40, FP60, and FP80, were obtained by graded... | ['Bifidobacterium adolescentis', 'Fatty Acids', 'Fermentation', 'Hydrogen-Ion Concentration', 'Lactic Acid', 'Molecular Conformation', 'Molecular Weight', 'Polysaccharides', 'Rutaceae'] | 30,465,831 | [['B03.510.024.100.125', 'B03.510.460.400.400.049.100.125'], ['D10.251'], ['G02.111.158.249', 'G03.191.249'], ['G02.300'], ['D02.241.511.459.450'], ['G02.111.570.820'], ['G02.494'], ['D09.698'], ['B01.650.940.800.575.912.250.875']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preparation of Xenopus laevis retinal cryosections for electron microscopy. | Transmission electron microscopy is the gold standard for examination of photoreceptor outer segment morphology and photoreceptor outer segment abnormalities in transgenic animal models of retinal disease. Small vertebrates such as zebrafish and Xenopus laevis tadpoles have been used to generate retinal disease models ... | ['Animals', 'Cryoultramicrotomy', 'Histocytological Preparation Techniques', 'Microscopy, Electron, Transmission', 'Retina', 'Tissue Embedding', 'Tissue Fixation', 'Xenopus laevis'] | 26,008,144 | [['B01.050'], ['E01.370.225.500.620.530.160', 'E01.370.225.750.600.530.160', 'E05.200.500.620.530.160', 'E05.200.750.600.530.160'], ['E01.370.225.500.620', 'E01.370.225.750.600', 'E05.200.500.620', 'E05.200.750.600'], ['E01.370.350.515.402.580', 'E05.595.402.580'], ['A09.371.729'], ['E01.370.225.500.620.760.440', 'E01.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Automatic craniofacial structure detection on cephalometric images. | Anatomical structure tracing on cephalograms is a significant way to obtain cephalometric analysis. Cephalometric analysis is divided in two categories, manual and automatic approaches. The manual approach is limited in accuracy and repeatability due to differences in inter- and intra-personal marking. In this paper, w... | ['Algorithms', 'Cephalometry', 'Databases, Factual', 'Face', 'Head', 'Humans', 'Image Processing, Computer-Assisted', 'Radiography', 'Reproducibility of Results', 'Skull'] | 21,435,982 | [['G17.035', 'L01.224.050'], ['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['A01.456.505'], ['A01.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.700'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Lemierre's syndrome complicating pregnancy. | Lemierre's syndrome is an anaerobic suppurative thrombophlebitis involving the internal jugular vein secondary to oropharyngeal infection. There is only one previous case report in pregnancy which was complicated by premature delivery of an infant that suffered significant neurological damage. We present an atypical ca... | ['Acute Disease', 'Adult', 'Anti-Bacterial Agents', 'Female', 'Humans', 'Infant, Newborn', 'Jugular Veins', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Pregnancy Outcome', 'Sepsis', 'Thrombophlebitis'] | 17,710,241 | [['C23.550.291.125'], ['M01.060.116'], ['D27.505.954.122.085'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['A07.015.908.498'], ['G08.686.784.769'], ['C01.674', 'C13.703.700'], ['E01.789.700', 'G08.686.784.769.496'], ['C01.757', 'C23.550.470.790.500'], ['C14.907.355.830.925.770', 'C14.907.617... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes. | OBJECTIVE: To determine the in-vitro effects of several non-steroidal antiinflammatory drugs and the glucocorticoid dexamethasone on the IL-1 altered expression and activity of MMP-1, MMP-3 and TIMP-1 by bovine articular chondrocytes.DESIGN: Bovine chondrocytes were cultured in alginate gel beads. Cells were treated wi... | ['Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Cartilage, Articular', 'Cattle', 'Cells, Cultured', 'Chondrocytes', 'Collagenases', 'Dexamethasone', 'Glucocorticoids', 'Indomethacin', 'Interleukin-1', 'Male', 'Matrix Metalloproteinase 1', 'Matrix Metalloproteinase 3', 'Matrix Metalloproteinases', 'Meloxicam', '... | 11,467,888 | [['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['A02.165.407.150', 'A02.835.583.192'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['A11.329.171'], ['D08.811.277.656.300.480.205', 'D08.811.277.656.675.374.205'], ['D04.210.500.745.432.769.344', 'D04.210.500.908... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metal complexes derived from hydrazoneoxime ligands: V. Spectral and structural studies on diacetylmonoxime n-alkanoylhydrazones and their nickel(II) and copper(II) complexes. | A series of diacetylmonoxime n-alkanoylhydrazones (H₂L(n), n=4, 5, 6, 12 and 16) were prepared by the condensation of diacetylmonoxime with the corresponding n-alkanoylhydrazine in ethanol. The X-ray crystal structure of diacetylmonoxime octadecanoyl hydrazone has been solved and its molecular and supramolecular struct... | ['Chemistry Techniques, Synthetic', 'Coordination Complexes', 'Copper', 'Crystallography, X-Ray', 'Diacetyl', 'Dimerization', 'Magnetic Resonance Spectroscopy', 'Magnetics', 'Molecular Structure', 'Nickel', 'Spectrophotometry, Infrared', 'Spectrophotometry, Ultraviolet'] | 25,022,497 | [['E05.197', 'J01.897.836.249'], ['D01.234', 'D02.257'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E05.196.309.742.225'], ['D02.522.296.400'], ['G02.206', 'G03.230'], ['E05.196.867.519'], ['H01.671.493'], ['G02.111.570', 'G02.466'], ['D01.268.556.607', 'D01.268.956.625', 'D01.552.544.607'], ['E05.196... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
[Training in health education in child welfare nursing schools: a survey of teachers and students]. | The emergence of new nurses' profile, stemming from study program of 1992, has urged nursery-nurse schools to think about their current training program. We have hold an inquiry in these schools to know how this new profile could be a factor to make easier the training in health education. We have also asked nursery-nu... | ['Adolescent', 'Adult', 'Age Factors', 'Child', 'Child, Preschool', 'Clinical Competence', 'Communication', 'Curriculum', 'Educational Technology', 'Faculty, Nursing', 'Female', 'Health Education', 'Health Services Needs and Demand', 'Humans', 'Male', 'Middle Aged', 'Nurse-Patient Relations', 'Patient Education as Topi... | 11,142,197 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['M01.060.406.448'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['F01.145.209', 'L01.143'], ['I02.158'], ['J01.897.280'], ['M01.526.485.390', 'M01.526.702.250.473', 'N02.360.390'], ['I02.233.332', 'N02.421.726.407'], ['N... | ['Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equ... | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
Reoperation for metalwork complications following the use of volar locking plates for distal radius fractures: a United Kingdom experience. | Volar locking plates are increasingly used in the management of distal radius fractures. As with any new implant, understanding the rate and type of potential metalwork related complications is important. In this study, we reviewed 114 distal radius fractures treated with volar locking plating. Our aim was to determine... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Bone Plates', 'Bone Screws', 'Female', 'Follow-Up Studies', 'Fracture Fixation, Internal', 'Fracture Healing', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Postoperative Complications', 'Radiography', 'Radius Fractures', 'Reoperation', 'Retrospective Studies', 'Un... | 21,548,144 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.695.370.374', 'E07.858.442.660.460.374', 'E07.858.690.725.460.374'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effect of smoking on failure of H. pylori therapy and gastric histology in a high gastric cancer risk area of Colombia. | It has been proposed that eradication of Helicobacter pylori infection is a sound strategy for gastric cancer prevention. Several factors including smoking have been associated to treatment failure rates. This study aimed to evaluate the smoking effect on the efficacy of H. pylori therapy, as well as on the histologica... | ['Amoxicillin', 'Anti-Infective Agents', 'Bismuth', 'Colombia', 'Drug Therapy, Combination', 'Female', 'Follow-Up Studies', 'Gastric Mucosa', 'Gastritis, Atrophic', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Male', 'Metaplasia', 'Metronidazole', 'Organometallic Compounds', 'Precancerous Conditions', '... | 18,254,262 | [['D02.065.589.099.750.750.050.050', 'D02.886.108.750.750.050.050', 'D03.633.100.300.750.750.050.050'], ['D27.505.954.122'], ['D01.268.271.245', 'D01.268.556.100', 'D01.496.749.305.245', 'D01.552.544.100'], ['Z01.107.757.284'], ['E02.319.310'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450... | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Global transcriptome profiling of Salicornia europaea L. shoots under NaCl treatment. | BACKGROUND: Soil salinity is a major abiotic stress that limits agriculture productivity worldwide. Salicornia europaea is well adapted to extreme saline environments with more than 1,000 mM NaCl in the soil, so it could serve as an important model species for studying halophilic mechanisms in euhalophytes. To obtain i... | ['Chenopodiaceae', 'Gene Expression Profiling', 'Genes, Plant', 'Molecular Sequence Annotation', 'Sodium Chloride'] | 23,825,526 | [['B01.650.940.800.575.912.250.200'], ['E05.393.332'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['E05.393.760.479', 'L01.453.245.667.580'], ['D01.210.450.150.875', 'D01.857.650']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Picocyanobacteria containing a novel pigment gene cluster dominate the brackish water Baltic Sea. | Photoautotrophic picocyanobacteria harvest light via phycobilisomes (PBS) consisting of the pigments phycocyanin (PC) and phycoerythrin (PE), encoded by genes in conserved gene clusters. The presence and arrangement of these gene clusters give picocyanobacteria characteristic light absorption properties and allow the c... | ['Cyanobacteria', 'Genes, Bacterial', 'Multigene Family', 'Oceans and Seas', 'Phycocyanin', 'Phycoerythrin', 'Phylogeny', 'Seawater'] | 24,621,524 | [['B03.280', 'B03.440.475.100'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G05.360.340.024.340.645'], ['G01.311.625', 'G16.500.275.725.500.650', 'Z01.756'], ['D05.500.562.488.490.500.500.755', 'D08.811.600.710.490.500.500.755', 'D12.776.765.650', 'D23.767.690'], ['D05.500.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Cardiovascular outcomes among sildenafil users: results of the International Men's Health Study. | AIM: To assess the incidence of serious cardiovascular disease (CVD) events [i.e. myocardial infarction (MI) and stroke] and all-cause mortality in men with erectile dysfunction (ED) who received prescriptions for sildenafil.METHODS: The International Men's Health Study (IMHS) was a prospective, observational cohort st... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Cardiovascular Diseases', 'Cohort Studies', 'Erectile Dysfunction', 'Humans', 'Male', "Men's Health", 'Middle Aged', 'Phosphodiesterase Inhibitors', 'Piperazines', 'Prospective Studies', 'Purines', 'Risk Factors', 'Sildenafil Citrate', 'Sulfones'] | 18,261,073 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C12.294.644.486', 'F03.835.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.400.425'], ['M01.060.116.630'], ['D27.505.519.389.735'], ['D... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Signature neural networks: definition and application to multidimensional sorting problems. | In this paper we present a self-organizing neural network paradigm that is able to discriminate information locally using a strategy for information coding and processing inspired in recent findings in living neural systems. The proposed neural network uses: 1) neural signatures to identify each unit in the network; 2)... | ['Algorithms', 'Artificial Intelligence', 'Electronic Data Processing', 'Neural Networks, Computer', 'Neurons', 'Pattern Recognition, Automated'] | 21,095,867 | [['G17.035', 'L01.224.050'], ['G17.035.250', 'L01.224.050.375'], ['L01.224.085'], ['G17.485', 'L01.224.050.375.605'], ['A08.675', 'A11.671'], ['L01.399.750']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The short extracellular domain of the T cell receptor zeta chain is involved in assembly and signal transduction. | The zeta chain is required in the TCR complex to guarantee its surface expression and function. However, an understanding of the interaction(s) between the zeta chain and the other proteins in the TCR/CD3 has not yet been achieved. In this report, we attempt to assign a functional role to the short extracellular (EC) d... | ['Amino Acid Sequence', 'Binding Sites', 'CD3 Complex', 'Extracellular Matrix', 'Humans', 'Membrane Proteins', 'Molecular Sequence Data', 'Phosphorylation', 'Protein Binding', 'Receptors, Antigen, T-Cell', 'Receptors, Antigen, T-Cell, alpha-beta', 'Signal Transduction', 'Surface Properties', 'Tumor Cells, Cultured'] | 9,464,517 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.120'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['A11.284.295.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543'], ['L01.453.245.667'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['G02.111.679', 'G03.808'], ['D12.776.543.750.705.8... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Hyperlipoproteinemia, hyperinsulinism, and Meniere's disease. | Since first reporting the association of hyperlipoproteinemia with inner ear disease in a study of 300 patients in 1973, I have continued to focus attention on the presence of lipid abnormalities in patients with inner ear dysfunction. With over 1,400 patients now identified with both abnormal lipids and inner ear symp... | ['Humans', 'Hyperinsulinism', 'Hyperlipoproteinemias', 'Meniere Disease'] | 7,292,056 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968'], ['C18.452.584.500.500.644'], ['C09.218.568.217.500']] | ['Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Relationship of serum haloperidol levels to clinical response in schizophrenic patients. | The authors treated 16 outpatients and 1 inpatient who had diagnoses of schizophrenia in exacerbation with haloperidol as the sole neuroleptic agent and obtained ratings of psychopathology and serum levels of haloperidol. Improvement in schizophrenic symptoms measured by the Brief Psychiatric Rating Scale was significa... | ['Acute Disease', 'Adolescent', 'Adult', 'Female', 'Haloperidol', 'Humans', 'Male', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Schizophrenia', 'Schizophrenic Psychology'] | 7,468,835 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['D02.522.352.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.711.513.653'], ['F03.700.750'], ['F04.824']] | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nucleotide sequence, expression and transcriptional analysis of the Bifidobacterium longum MB 219 lacZ gene. | The gene encoding beta-galactosidase was isolated by functional complementation of Escherichia coli from Bifidobacterium longum MB219, which exhibited the highest activity among ten Bifidobacterium strains tested of the species B. longum, B. breve, B. adolescentis, B. indicum, B. animalis and B. cuniculi. The nucleotid... | ['Base Sequence', 'Bifidobacterium', 'Cloning, Molecular', 'DNA Primers', 'DNA, Bacterial', 'Escherichia coli', 'Gene Expression', 'Genes, Bacterial', 'Lac Operon', 'Species Specificity', 'Transcription, Genetic', 'beta-Galactosidase'] | 10,985,745 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B03.510.024.100', 'B03.510.460.400.400.049.100'], ['E05.393.220'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.212'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.297'], ['G05.360.340.024.340.364.249', 'G05.360.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Haemodynamic factors influencing myocardial ischaemia in a canine model of coronary artery stenosis: the effects of nitroglycerine. | At a critical degree of coronary stenosis (allowing a just adequate blood supply to the poststenotic area only at the expense of maximal hypoxic coronary vasodilatation), an additional loading of the heart induced marked local myocardial ischaemia, as indicated by appropriate biochemical, electrophysiological and haemo... | ['Animals', 'Coronary Circulation', 'Coronary Disease', 'Dogs', 'Female', 'Hemodynamics', 'Male', 'Nitroglycerin'] | 6,418,244 | [['B01.050'], ['G09.330.100.324'], ['C14.280.647.250', 'C14.907.585.250'], ['B01.050.150.900.649.313.750.250.216.200'], ['G09.330.380'], ['D02.640.636']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impediment to symbiosis establishment between giant clams and Symbiodinium algae due to sterilization of seawater. | To survive the juvenile stage, giant clam juveniles need to establish a symbiotic relationship with the microalgae Symbiodinium occurring in the environment. The percentage of giant clam juveniles succeeding in symbiosis establishment ("symbiosis rate") is often low, which is problematic for seed producers. We investig... | ['Animals', 'Bivalvia', 'Dinoflagellida', 'Seawater', 'Sterilization', 'Symbiosis'] | 23,613,802 | [['B01.050'], ['B01.050.500.644.080'], ['B01.043.214'], ['G16.500.275.725.500'], ['N06.850.780.200.450.850'], ['G06.550.800', 'G16.840']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A community-based assessment of heat-related morbidity in North Philadelphia. | A 6-month community-based study designed to (1) determine the perceptions and barriers affecting the overall quality of life of isolated older adults greater than 65 years of age, (2) assess their risk factors, health attitudes, and beliefs concerning their susceptibility to heat-related conditions, and (3) evaluate th... | ['Aged', 'Aged, 80 and over', 'Aging', 'Attitude to Health', 'Education', 'Female', 'Geriatrics', 'Health Surveys', 'Heat Stroke', 'Hot Temperature', 'Humans', 'Male', 'Mortality', 'Philadelphia', 'Quality of Life', 'Risk Assessment', 'Urban Population'] | 10,944,078 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['F01.100.150', 'N05.300.150'], ['I02'], ['H02.403.355'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['C26.522.500'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Geographica... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Slit-surface electrospinning: a novel process developed for high-throughput fabrication of core-sheath fibers. | In this work, we report on the development of slit-surface electrospinning--a process that co-localizes two solutions along a slit surface to spontaneously emit multiple core-sheath cone-jets at rates of up to 1 L/h. To the best of our knowledge, this is the first time that production of electrospun core-sheath fibers ... | ['Nanofibers'] | 25,938,411 | [['J01.637.512.300']] | ['Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Psychotropic medication and nonfatal cafe coronary. | Obstructive asphyxia, also known as cafe coronary, has been linked to both medicated and nonmedicated psychiatric patients. An 18-month prospective audit of choking patients was conducted in a psychiatric hospital. Based upon all medications received in the 5 days preceding the event, mean daily chlorpromazine and atro... | ['Age Factors', 'Airway Obstruction', 'Atropine', 'Chlorpromazine', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Middle Aged', 'Parasympatholytics', 'Psychotropic Drugs', 'Regression Analysis', 'Risk'] | 3,700,693 | [['N05.715.350.075', 'N06.850.490.250'], ['C08.618.846.185'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['D02.886.369.198', 'D03.633.300.783.198'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['M01.060.116.630']... | ['Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pulmonary function in progressive systemic sclerosis. Comparison of CREST syndrome variant with diffuse scleroderma. | The pulmonary function and chest roentgenograms were evaluated in 88 patients with the CREST syndrome variant of progressive systemic sclerosis (PSS or scleroderma). Seventy-two percent of the patients had abnormal pulmonary function. An isolated decrease in diffusing capacity was the most common abnormality noted, fol... | ['Adult', 'Calcinosis', 'Female', 'Humans', 'Lung', 'Lung Diseases', 'Male', 'Middle Aged', 'Radiography', 'Respiratory Function Tests', 'Retrospective Studies', 'Ribs', 'Scleroderma, Systemic', 'Syndrome'] | 6,628,005 | [['M01.060.116'], ['C18.452.174.130'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C08.381'], ['M01.060.116.630'], ['E01.370.350.700'], ['E01.370.386.700'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.5... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Presence of lipids in urinary stones: results of preliminary studies. | The presence of lipids in urinary stones was determined by histochemical and biochemical methods. When crystals of calcium oxalate, made by mixing calcium chloride and potassium oxalate solutions and sections of human calcium oxalate urinary stones, were exposed to osmium vapors, there was no staining of the pure cryst... | ['Calcium Oxalate', 'Histocytochemistry', 'Humans', 'Magnesium', 'Magnesium Compounds', 'Microscopy, Electron, Scanning', 'Phosphates', 'Phospholipids', 'Struvite', 'Uric Acid', 'Urinary Calculi'] | 3,127,030 | [['D02.241.081.337.593.750.500'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['D01.524'], ['E01.370.350.515.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cryopreservation of apple using non-desiccated sections from winter-collected scions. | Winter vegetative buds of Malus species are cryopreserved at USDA-ARS NCGRP to backup genetic resources maintained by field collections. The method uses desiccation of nodal sections prior to cooling but is time and labor intensive, and can damage materials if excessive. Here we tested cooling sections without prior de... | ['Cell Survival', 'Cryopreservation', 'Desiccation', 'Malus', 'Nitrogen', 'Plant Stems', 'Temperature'] | 19,827,248 | [['G04.346'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['E05.196.335', 'G02.176'], ['B01.650.940.800.575.912.250.859.937.500.444'], ['D01.268.604', 'D01.362.625'], ['A18.024.937'], ['G01.906.595', 'G16.500.275.063... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Estrous cycle synchronization in the Persian onager (Equus hemionus onager). | The endangered Persian onager (Equus hemionus onager) has experienced significant population declines over the past century due to poaching, habitat destruction, and resource competition. Remaining animals in zoos and the wild are regionally isolated. Artificial insemination (AI) may be particularly useful as a means o... | ['Animals', 'Animals, Zoo', 'Endangered Species', 'Equidae', 'Estrus Synchronization', 'Female', 'Insemination, Artificial', 'Ultrasonography'] | 26,849,100 | [['B01.050'], ['B01.050.050.448'], ['B01.050.050.565', 'G16.500.275.157.049.250', 'N06.230.080.200', 'N06.230.124.049.250'], ['B01.050.150.900.649.313.984.235'], ['E05.820.150.370', 'G08.686.195.500.500'], ['E02.875.800.937', 'E05.820.800.937', 'G08.686.784.363.492'], ['E01.370.350.850']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Partial immunologic reconstitution and hyperimmunoglobulinemia-E in neonatally-acquired graft-versus-host disease. | A three-month-old girl with congenital immune deficiency developed graft-versus-host disease following engraftment of maternal immunocompetent cells. T and B lymphocyte numbers increased and lymphocyte responsiveness to phytohemagglutinin normalized during the patient's hospitalization. However, these cells failed to r... | ['B-Lymphocytes', 'Erythrocytes', 'Female', 'Graft vs Host Reaction', 'HLA Antigens', 'Humans', 'Hypergammaglobulinemia', 'Immunoglobulin E', 'Immunologic Deficiency Syndromes', 'Infant', 'Infant, Newborn', 'Infant, Newborn, Diseases', 'Leukocyte Count', 'Lymphocyte Activation', 'Phytohemagglutinins', 'Pokeweed Mitogen... | 6,966,144 | [['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G12.875.402'], ['D23.050.301.500.450', 'D23.050.705.552.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.378.147.542', 'C20.683.460'... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Influence of hydrostatic pressure and sound amplitude on the ultrasound induced dispersion and de-agglomeration of nanoparticles. | In most applications, nanoparticles are required to be in a well-dispersed state prior to commercialisation. Conventional technology for dispersing particles into liquids, however, usually is not sufficient, since the nanoparticles tend to form very strong agglomerates requiring extremely high specific energy inputs in... | ['Algorithms', 'Gases', 'Hydrostatic Pressure', 'Nanoparticles', 'Particle Size', 'Ultrasonics'] | 17,977,777 | [['G17.035', 'L01.224.050'], ['D01.362'], ['G01.374.715.352'], ['J01.637.512.600'], ['G02.712'], ['H01.671.031.849']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Perioperative Management of a Patient with Severe Factor V Deficiency Presenting with Chronic Subdural Hematoma: A Clinical Report. | BACKGROUND: Severe factor V deficiency is an extremely rare coagulation disorder. Patients with factor V activity <5% usually become symptomatic in early childhood.CASE DESCRIPTION: We report the case of an 82-year-old woman with incidentally diagnosed severe factor V deficiency, who developed a symptomatic chronic sub... | ['Aged, 80 and over', 'Disease Management', 'Factor V Deficiency', 'Female', 'Hematoma, Subdural, Chronic', 'Humans', 'Perioperative Care', 'Severity of Illness Index', 'Treatment Outcome'] | 30,999,086 | [['M01.060.116.100.080'], ['N04.590.607'], ['C15.378.100.100.300', 'C15.378.100.141.300', 'C15.378.463.300', 'C16.320.099.300'], ['C10.228.140.300.535.450.400.120', 'C10.900.300.837.600.120', 'C14.907.253.573.400.450.120', 'C23.550.414.838.700.200', 'C23.550.414.913.700.200', 'C26.915.300.490.450.120'], ['B01.050.150.9... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nutrition and pancreatic enzyme intake in patients with cystic fibrosis with distal intestinal obstruction syndrome. | BACKGROUND: The etiology of distal intestinal obstruction syndrome (DIOS) remains unclear. Food intake and pancreatic enzyme replacement therapy (PERT) are often blamed for its occurrence. This study evaluates the nutrition intake and PERT of patients with cystic fibrosis (CF) at a first episode of DIOS.METHODS: All pa... | ['Adolescent', 'Adult', 'Case-Control Studies', 'Child', 'Child, Preschool', 'Cystic Fibrosis', 'Dietary Fats', 'Eating', 'Enzyme Replacement Therapy', 'Female', 'Follow-Up Studies', 'Humans', 'Intestinal Obstruction', 'Lipase', 'Male', 'Nutritional Status', 'Pancreas', 'Time Factors', 'Treatment Outcome', 'Young Adult... | 25,288,253 | [['M01.060.057'], ['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['M01.060.406.448'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['G07.203.650.283', 'G10.261.330'], ['E02.319.353.500']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Effect of age on red cell membrane sodium -potassium dependent adenosine triphosphatase (Na+-K+ ATPase) activity in healthy men. | Decreased cellular thermogenesis may represent a normal aspect of the aging process. Whereas Na+-K+ ATPase appears to be involved directly in body metabolism, enzyme activity on the erythrocyte membrane Na+-K+ ATPase was significantly lower in aged men. In a separate series of experiments, each with representation from... | ['Adult', 'Aged', 'Aging', 'Erythrocyte Membrane', 'Erythrocytes', 'Humans', 'Male', 'Middle Aged', 'Sodium-Potassium-Exchanging ATPase'] | 6,294,172 | [['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D08.811.277.040.025.314.750', 'D12.776.157.530.450.162.780', 'D12.776.157.530.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Action-dependent perceptual invariants: from ecological to sensorimotor approaches. | Ecological and sensorimotor theories of perception build on the notion of action-dependent invariants as the basic structures underlying perceptual capacities. In this paper we contrast the assumptions these theories make on the nature of perceptual information modulated by action. By focusing on the question, how move... | ['Attention', 'Awareness', 'Humans', 'Kinesthesis', 'Orientation', 'Psychological Theory', 'Psychomotor Performance', 'Social Environment', 'Touch', 'Visual Perception'] | 18,226,924 | [['F02.830.104.214'], ['F02.463.188.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.830.816.541.504', 'G11.561.790.541.587'], ['F01.058.577', 'F02.830.606'], ['F02.739'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['I01.880.853.500'], ['F02.830.816.850', 'G11.561.790.850'], ['F02.463.593.932']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Exacerbated pressor and sympathoexcitatory effects of central Elabela in spontaneously hypertensive rats. | Elabela (ELA) is a newly discovered peptide that acts as a novel endogenous ligand of angiotensin receptor-like 1 (APJ) receptor. This study was designed to evaluate the effects of ELA-21 in paraventricular nucleus (PVN) on blood pressure and sympathetic nerve activity in spontaneously hypertensive rats (SHR). Experime... | ['Animals', 'Arginine Vasopressin', 'Arterial Pressure', 'Class Ia Phosphatidylinositol 3-Kinase', 'Disease Models, Animal', 'Heart Rate', 'Hypertension', 'Injections, Intravenous', 'Male', 'Microinjections', 'Norepinephrine', 'Paraventricular Hypothalamic Nucleus', 'Peptide Hormones', 'Phosphorylation', 'Proto-Oncogen... | 31,834,836 | [['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['G09.330.380.076.347'], ['D08.811.913.696.620.500.100.100.100', 'D08.811.913.696.620.500.200.100.100', 'D12.776.476.162.100'], ['C22.232', 'E05.598.500', 'E05.599.395.0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prophylactic ureteric catheters in laparoscopic colorectal surgery. | BACKGROUND: The purpose of this study was to evaluate the use of ureteric catheter placement in laparoscopic colorectal surgery and to assess the morbidity related to this procedure.METHODS: Between 1994 and 2001, 313 elective laparoscopic colorectal surgeries were performed. Patients with and without ureteric catheter... | ['Antibiotic Prophylaxis', 'Colorectal Surgery', 'Female', 'Humans', 'Laparoscopy', 'Male', 'Middle Aged', 'Retrospective Studies', 'Statistics, Nonparametric', 'Treatment Outcome', 'Ureter', 'Urinary Catheterization', 'Urinary Tract Infections'] | 18,512,012 | [['E02.319.162.150', 'E02.319.703.150'], ['H02.403.810.208'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.50... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn. | As part of a search for novel inhibitors of HIV-1 reverse transcriptase, the acetone extract of the giant African snail, Achatina fulica, was shown to be active. Fractionation of the extract yielded inophyllums A, B, C, and E and calophyllolide (1a, 2a, 3a, 3b, and 6), previously isolated from Calophyllum inophyllum Li... | ['Acetylation', 'Animals', 'Chromans', 'Crystallization', 'Crystallography, X-Ray', 'HIV Reverse Transcriptase', 'HIV-1', 'Magnetic Resonance Spectroscopy', 'Molecular Conformation', 'Molecular Structure', 'Reverse Transcriptase Inhibitors', 'Snails', 'Structure-Activity Relationship', 'Trees'] | 7,506,311 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['B01.050'], ['D03.383.663.283.240', 'D03.633.100.150.240'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D08.811.913.696.445.308.300.750.187', 'D12.776.964.775.375.545.875', 'D12.776.964.775.375.750.187', 'D12.776.964.775.562.764.875', 'D12.776.964.900.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel Medical Achievement Self-efficacy Scale (MASS): a valid and reliable tool. | In search for an instrument to measure overall curriculum impact, we developed a Medical Achievement Self-efficacy Scale (MASS) and presented it to medical students enrolled in the different years of the integrated Ghent curriculum. The research aim was to study the validity and reliability of this new scale. MASS item... | ['Achievement', 'Attitude of Health Personnel', 'Clinical Competence', 'Curriculum', 'Education, Medical', 'Educational Measurement', 'Humans', 'Pilot Projects', 'Reproducibility of Results', 'Self Efficacy'] | 23,701,248 | [['F01.658.059', 'F02.784.629.054'], ['F01.100.050', 'N05.300.100'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.158'], ['I02.358.399'], ['I02.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['E05.318.370.725', 'E05.3... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Does multiple-dose charcoal therapy enhance salicylate excretion? | Multiple-dose charcoal therapy has been shown to increase the excretion of some drugs. This study assesses the effects of this intervention on salicylate excretion in the postabsorptive phase. Ten human volunteers participated in this randomized, controlled, crossover, two-limbed protocol. On two occasions each volunte... | ['Adult', 'Aspirin', 'Charcoal', 'Drug Administration Schedule', 'Female', 'Humans', 'Male', 'Randomized Controlled Trials as Topic', 'Reference Values'] | 2,191,636 | [['M01.060.116'], ['D02.455.426.559.389.657.410.595.176'], ['D01.268.150.150'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.500', 'N06.850.520.450.250.250.365.500'], ['E05.978.810']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mannitol and renal dysfunction after endovascular aortic aneurysm repair procedures: a randomized trial. | OBJECTIVE: Endovascular aortic aneurysm repair (EVAR) may result in deterioration of renal function. Mannitol has renovascular and antioxidant properties that could prove beneficial in this respect.DESIGN: A randomized prospective study.SETTING: Attikon University Hospital, single institution.PARTICIPANTS: Eighty-six p... | ['Aged', 'Aortic Aneurysm, Abdominal', 'Blood Vessel Prosthesis', 'Creatinine', 'Cystatin C', 'Diuretics, Osmotic', 'Elective Surgical Procedures', 'Endovascular Procedures', 'Female', 'Follow-Up Studies', 'Glomerular Filtration Rate', 'Humans', 'Infusions, Intravenous', 'Kidney', 'Kidney Function Tests', 'Male', 'Mann... | 24,332,919 | [['M01.060.116.100'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['E07.695.110'], ['D03.383.129.308.207'], ['D12.776.215.300'], ['D27.505.696.560.500.453'], ['E04.249'], ['E04.100.814.529', 'E04.502.382'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E01.370.390.400.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity. | Embryo implantation requires a healthy embryo and a receptive uterus. In women, the inner lining of the uterus, the endometrium, remains in a hostile state and becomes receptive for embryo implantation for only a short period during each menstrual cycle. Determining endometrial receptivity is vital in in vitro fertiliz... | ['Animals', 'Antibodies, Monoclonal, Murine-Derived', 'Embryo Implantation', 'Endometrium', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Mice', 'Proprotein Convertase 5'] | 25,554,488 | [['B01.050'], ['D12.776.124.486.485.114.224.075', 'D12.776.124.790.651.114.224.075', 'D12.776.377.715.548.114.224.284'], ['G08.686.784.170.104.500'], ['A05.360.319.679.490'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.98... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Xanthogranulomatous pyelonephritis in childhood: ultrasound and CT diagnosis. | Four cases of diffuse xanthogranulomatous pyelonephritis (XPN) in young children are presented. In three patients the clinical picture was one of weight loss, anaemia and neutrophilia with a large renal mass. The fourth presented with haematuria. Ultrasound (US) and CT findings were almost identical in all four patient... | ['Child, Preschool', 'Humans', 'Infant', 'Pyelonephritis, Xanthogranulomatous', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 7,936,802 | [['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C12.777.419.570.643.790.810', 'C12.777.419.570.821.717.810', 'C13.351.968.419.570.643.790.810', 'C13.351.968.419.570.821.717.810'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Expression of human anti-HBsAg-interferon fusion protein in CHO cells]. | OBJECTIVE: To study the possibility of expressing human anti-HBsAg-interferon fusion protein in CHO cells as a putative targeting drug for hepatitis B.METHODS: Both the heavy and light chain genes of human anti-HBsAg antibody derived from a phage display library were fused with alpha-2b interferon (IFN-alpha-2b) gene i... | ['Animals', 'CHO Cells', 'Cricetinae', 'Enzyme-Linked Immunosorbent Assay', 'Hepatitis B', 'Hepatitis B Antibodies', 'Hepatitis B Surface Antigens', 'Humans', 'Interferons', 'Recombinant Fusion Proteins'] | 11,350,695 | [['B01.050'], ['A11.251.210.200', 'A11.436.155'], ['B01.050.150.900.649.313.992.635.075.250'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D12.776.124.486.485.... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gas chromatographic-mass spectrometric determination of myo-inositol in human cerebrospinal fluid. | The concentration of free myo-inositol in CSF was determined with a gas chromatographic-mass spectrometric method using deuterated myo-inositol as an internal standard after conversion to the hexa-O-acetyl derivative with acetic anhydride and pyridine. Twenty microliters of CSF is sufficient for the analysis which has ... | ['Adult', 'Arthritis, Rheumatoid', 'Chlorpromazine', 'Female', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Inositol', 'Male', 'Middle Aged', 'Nervous System Diseases', 'Schizophrenia', 'Subarachnoid Hemorrhage', 'Sulpiride'] | 4,009,166 | [['M01.060.116'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D02.886.369.198', 'D03.633.300.783.198'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.800.519', 'D09.853.519'], ['M01.060.116.630'], ['C10'], ['F03.700.750'], ['C10.228.14... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Breast diseases (fibroadenomas, mastopathies, breast cancers) in hormonal contraception]. | 282 female patients with histologically confirmed fibroadenomas (71), mastopathies (187) and breast carcinomas (24) were questioned for hormonal contraception. 144 women had taken oral steroid contraceptive pills, 138 denied such treatment. Statistically significant differences could not be observed in the occurrence o... | ['Adult', 'Breast', 'Breast Neoplasms', 'Contraceptives, Oral', 'Female', 'Fibrocystic Breast Disease', 'Fibroma', 'Humans', 'Middle Aged', 'Risk Factors'] | 3,239,299 | [['M01.060.116'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['D27.505.696.875.360.276.210', 'D27.505.954.705.360.276.210'], ['C17.800.090.750'], ['C04.557.450.565.590.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.6... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A normal rate of cellular cholesterol removal can be mediated by plasma from a patient with familial lecithin-cholesterol acyltransferase (LCAT) deficiency. | Lecithin-cholesterol acyltransferase (LCAT) is the major enzyme involved in the esterification of cholesterol in circulating plasma lipoproteins. In the present study, we describe the molecular defects in the LCAT gene and in lipoprotein metabolism of a 34-year-old patient presenting with features of classic familial L... | ['Adult', 'Apolipoproteins', 'Arginine', 'Cells, Cultured', 'Cholesterol', 'Cystine', 'DNA, Complementary', 'Fibroblasts', 'Humans', 'Kinetics', 'Lecithin Cholesterol Acyltransferase Deficiency', 'Lipids', 'Lipoproteins', 'Male', 'Phenotype', 'Point Mutation', 'Reverse Transcriptase Polymerase Chain Reaction'] | 11,718,688 | [['M01.060.116'], ['D10.532.091', 'D12.776.070.400', 'D12.776.521.120'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['A11.251'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D01.248.497.158.874.390.369', 'D01.875.350.850.150.369', 'D02.886.030.230.369', 'D02.886.520.150.0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The quality of obstetric care in family practice: are family physicians as safe as obstetricians? | A literature review on the quality of obstetric care in family practice was conducted to determine whether family physicians are as competent in providing obstetric care as obstetricians. Three types of studies were reviewed: case series, historical cohorts, and population-based studies. No conclusion on the quality of... | ['Clinical Competence', 'Family Practice', 'Female', 'Humans', 'Infant Mortality', 'Infant, Newborn', 'New Zealand', 'Obstetrics', 'Ontario', 'Outcome and Process Assessment, Health Care', 'Pregnancy', 'Quality of Health Care', 'Referral and Consultation', 'Research Design', 'United Kingdom', 'United States'] | 3,806,027 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.550.475', 'N01.224.935.698.489', 'N06.850.505.400.975.550.475', 'N06.850.520.308.985.550.475'], ['M01.060.703.520'], ['Z01.639.760.747', 'Z01.678.100.747'], ['H02.403.810.450'], ['... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
High complete remission rate and durable remissions achieved with rational use of autologous stem-cell transplantation, thalidomide maintenance, and non-myeloablative allogeneic transplantation in patients with multiple myeloma. | Autologous stem-cell transplantation (ASCT) has emerged as the standard approach in patients with multiple myeloma, although it is unlikely to achieve cure. Thalidomide maintenance and non-myeloablative allogeneic transplantation (NST) may increase complete remission (CR) rate and increase overall survival. In this stu... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Boronic Acids', 'Bortezomib', 'Disease-Free Survival', 'Dose-Response Relationship, Drug', 'Female', 'Follow-Up Studies', 'Humans', 'Immunosuppressive Agents', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Pyrazines', 'Remission Induction', 'Stem Cell Transplantation', 'Surviva... | 20,447,186 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['D01.029.260.110', 'D01.132.285', 'D02.203.200'], ['D01.029.260.110.500', 'D01.132.285.500', 'D02.203.200.500', 'D03.383.679.450'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment. | To develop efficient synergistic or additive combinations of chemopreventive and nutritional agents to reduce the risk of colon cancer, experiments were designed to test the application of a selective cyclooxygenase-2 (COX-2) inhibitor together with dietary omega-3 polyunsaturated fatty acids (PUFAs), such as decosahex... | ['Apoptosis', 'Celecoxib', 'Cell Division', 'Cell Line, Tumor', 'Colonic Neoplasms', 'Cyclooxygenase 2', 'Cyclooxygenase 2 Inhibitors', 'Cyclooxygenase Inhibitors', 'Docosahexaenoic Acids', 'Humans', 'Isoenzymes', 'Membrane Proteins', 'Prostaglandin-Endoperoxide Synthases', 'Pyrazoles', 'Sulfonamides'] | 14,985,462 | [['G04.146.954.035'], ['D02.065.884.247', 'D02.886.590.700.247', 'D03.383.129.539.160'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210.190', 'A11.251.860.180'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biophysical characterization of the influence of salt on tetrameric SecB. | SecB is a tetrameric chaperone, with a monomeric molecular mass of 17 kDa, that is involved in protein translocation in Escherichia coli. It has been hypothesized that SecB undergoes a conformational change as a function of the salt concentration. To gain more insight into the salt-dependent behavior of SecB, we studie... | ['Bacterial Proteins', 'Chromatography, Gel', 'Escherichia coli', 'Light', 'Models, Chemical', 'Molecular Weight', 'Protein Structure, Quaternary', 'Salts', 'Scattering, Radiation', 'Ultracentrifugation'] | 11,423,428 | [['D12.776.097'], ['E05.196.181.400.250'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.599.495'], ['G02.494'], ['G02.111.570.820.709.550'], ['D01.786'], ['E05.196.822', 'G01.867'], ['E05.181.724', 'E05.196.941']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Organization of excitatory and inhibitory local networks in the caudal nucleus of tractus solitarius of rats revealed in in vitro slice preparation. | Morphological and physiological properties of neurons in the caudal nucleus of tractus solitarius (NTS) of rats were studied in vitro by whole-cell recording and intracellular staining with biocytin. Synaptic responses following the solitary tract stimulation were also investigated to elucidate anatomical substrates of... | ['Afferent Pathways', 'Animals', 'Cell Membrane', 'Central Nervous System', 'Electric Stimulation', 'In Vitro Techniques', 'Male', 'Nerve Net', 'Neural Inhibition', 'Neurons', 'Patch-Clamp Techniques', 'Peripheral Nervous System', 'Rats', 'Rats, Sprague-Dawley', 'Solitary Nucleus', 'Synaptic Transmission'] | 8,889,930 | [['A08.612.220'], ['B01.050'], ['A11.284.149'], ['A08.186'], ['E05.723.402'], ['E05.481'], ['A08.511'], ['G07.265.755', 'G11.561.616'], ['A08.675', 'A11.671'], ['E05.200.500.905', 'E05.242.800'], ['A08.800'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['A08.186.211.132... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors Influencing California Dental Hygienists' Involvement in School-Based Oral Health Programs. | PURPOSE: To assess the influence of community oral health experiences during entry-level dental hygiene education on participation in community oral health events after graduation and the facilitators and barriers experienced by dental hygienists in participating in these programs.METHODS: A 27-item survey, consisting ... | ['Attitude of Health Personnel', 'California', 'Dental Hygienists', 'Education, Dental', 'Educational Status', 'Female', 'Health Education, Dental', 'Humans', 'Male', 'Oral Health', 'Residence Characteristics', 'Schools, Dental', 'Students, Dental', 'Surveys and Questionnaires'] | 27,551,144 | [['F01.100.050', 'N05.300.100'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['M01.526.485.067.105.376', 'N02.360.067.105.376'], ['I02.358.274'], ['N01.824.196'], ['I02.233.332.374', 'N02.421.726.407.457', 'N06.890.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.400.535'], ['N01.224.791', 'N06... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Prevalence and risk factors of chronic kidney disease in the Thai adult population: Thai SEEK study. | BACKGROUND: Previous reports of chronic kidney disease (CKD) prevalence in Thailand varied from 4.3% to 13.8%. However, there were methodological concerns with these reports in terms of generalization and the accuracy of estimation. This study was, therefore, conducted to determine CKD prevalence and its risk factors i... | ['Adult', 'Age Factors', 'Chronic Disease', 'Creatinine', 'Cross-Sectional Studies', 'Female', 'Humans', 'Kidney Diseases', 'Male', 'Middle Aged', 'Prevalence', 'Risk Factors', 'Sex Factors', 'Thailand'] | 20,037,182 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C23.550.291.500'], ['D03.383.129.308.207'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419', 'C13.351.968.419'], ['M01.060.116.630'], ['E05.318.308.985.525.750', 'N0... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Stronger responses to darks along the ventral pathway of the cat visual cortex. | Light increments (brights) and decrements (darks) are differently processed throughout the early visual system. It is well known that a bias towards faster and stronger responses to darks is present in the retina, lateral geniculate nucleus and primary visual cortex. In humans, psychophysical and neurophysiological dat... | ['Animals', 'Cats', 'Photic Stimulation', 'Visual Cortex', 'Visual Pathways', 'Visual Perception'] | 30,549,336 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.723.729'], ['A08.186.211.200.885.287.500.571.735', 'A08.186.211.200.885.287.500.814.953'], ['A08.612.220.860'], ['F02.463.593.932']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phospholipid scramblase 1 expression is enhanced in patients with antiphospholipid syndrome. | OBJECTIVE: Thrombus formation is the key event of vascular manifestations in antiphospholipid syndrome (APS). Phosphatidylserine (PS) is normally sequestered in the inner leaflet of cell membranes. Externalization of PS occurs during cell activation and is essential for promoting blood coagulation and for the binding o... | ['Adult', 'Aged', 'Antibodies, Anticardiolipin', 'Antibodies, Antiphospholipid', 'Antiphospholipid Syndrome', 'Cell Line', 'Drug Synergism', 'Female', 'Flow Cytometry', 'Gene Expression Regulation, Enzymologic', 'Humans', 'Immunophenotyping', 'Interferon-alpha', 'Lipopolysaccharide Receptors', 'Male', 'Middle Aged', 'M... | 22,526,829 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.323.210.100', 'D12.776.124.790.651.114.323.210.100', 'D12.776.377.715.548.114.323.210.100'], ['D12.776.124.486.485.114.323.210', 'D12.776.124.790.651.114.323.210', 'D12.776.377.715.548.114.323.210'], ['C20.111.197'], ['A11.251.210'], ['G07.690.773.968.477... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Gene expression profile reveals deregulation of genes with relevant functions in the different subclasses of acute myeloid leukemia. | Bone marrow samples from 43 adult patients with de novo diagnosed acute myeloid leukemia (AML)--10 acute promyelocytic leukemias (APL) with t(15;17), four AML with inv(16), seven monocytic leukemias and 22 nonmonocytic leukemias--were analyzed using high-density oligonucleotide microarrays. Hierarchical clustering anal... | ['Adolescent', 'Adult', 'Aged', 'Cluster Analysis', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation, Leukemic', 'Humans', 'Leukemia, Monocytic, Acute', 'Leukemia, Myeloid, Acute', 'Leukemia, Promyelocytic, Acute', 'Male', 'Middle Aged', 'Phylogeny', 'Retrospective Studies'] | 15,674,361 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.393.332'], ['G05.308.370.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.275.484'], ['C04.557.337.539.275'], ['C04.557.337.539.275.700'], ['M01.060.116.630'], ['G05.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Effects of specific fatty acid acylation of phospholipase A2 on its interfacial binding and catalysis. | Monomeric phospholipase A2 (PLA2) from the venom of Agkistrodon piscivorus piscivorus (App-D49) was treated with 3-acyloxy-4-nitrobenzoic acids to acylate the epsilon-amino groups of two lysines (Lys-7 and Lys-10) in the amino terminal region. Resulting 7,10-diacylated-App-D49s, with acyl groups ranging from lauroyl to... | ['Acylation', 'Agkistrodon', 'Animals', 'Catalysis', 'Crotalid Venoms', 'Enzyme Activation', 'Fatty Acids', 'Liposomes', 'Phospholipases A', 'Phospholipases A2', 'Protein Binding', 'Protein Processing, Post-Translational', 'Substrate Specificity', 'Surface Properties', 'Thermodynamics'] | 7,918,373 | [['G02.111.012', 'G02.607.063', 'G03.040'], ['B01.050.150.900.833.672.125.937.240.250'], ['B01.050'], ['G02.130'], ['D20.888.850.960.200', 'D23.946.833.850.960.200'], ['G02.111.263', 'G03.328'], ['D10.251'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['D08.811.277.352.100.680.750'... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Volatile anesthetics and NMDA receptors. Enflurane inhibition of glutamate-stimulated [3H]MK-801 binding and reversal by glycine. | The influence of enflurane, a volatile general anesthetic, on [3H]MK-801 binding to a site in the ion channel of the N-methyl-D-aspartate (NMDA) receptor was determined in membranes from rat cerebral cortex. Enflurane disrupted glutamate stimulation of [3H]MK-801 (1 nM) binding with an IC50 of 0.4 mM. This inhibition w... | ['Animals', 'Cerebral Cortex', 'Dizocilpine Maleate', 'Enflurane', 'Excitatory Amino Acid Antagonists', 'Glutamates', 'Glutamic Acid', 'Glycine', 'Kinetics', 'Male', 'Rats', 'Rats, Inbred Strains', 'Receptors, N-Methyl-D-Aspartate'] | 1,686,307 | [['B01.050'], ['A08.186.211.200.885.287.500'], ['D02.455.426.559.847.181.384.380', 'D04.615.181.384.380'], ['D02.355.601.400'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['D12.125.067.625', 'D12.125.119.409'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['D12.125.481'], ['G01.374.66... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effects of cisapride on lower esophageal sphincter pressure and gastroduodenal motor activity in man]. | Manometric study was performed to investigate the effects of cisapride, a new non-antidopaminergic gastrointestinal prokinetic compound, on interdigestive lower esophageal sphincter pressure (LESP) and gastroduodenal motility using infused catheter technique. The subjects consisted of 9 healthy volunteers and 29 patien... | ['Adolescent', 'Adult', 'Aged', 'Cisapride', 'Duodenum', 'Electromyography', 'Esophagitis, Peptic', 'Esophagogastric Junction', 'Gastrointestinal Motility', 'Humans', 'Manometry', 'Middle Aged', 'Piperidines', 'Scleroderma, Systemic'] | 3,795,673 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D02.065.277.135', 'D02.241.223.100.050.500.644', 'D02.241.223.100.100.135', 'D02.241.223.100.200.374', 'D02.455.426.559.389.127.020.937.700', 'D02.455.426.559.389.127.085.135', 'D02.455.426.559.389.127.250.374', 'D03.383.621.135'], ['A03.556.124.684.124', 'A03.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Single-cell analysis of yeast, mammalian cells, and fungal spores with a microfluidic pressure-driven chip-based system. | BACKGROUND: Cytomics aims at understanding the function of cellular systems by analysis of single cells. Recently, there has been a growing interest in single cell measurements being performed in microfluidic systems. These systems promise to integrate staining, measurement, and analysis in a single system. One importa... | ['Cell Line', 'Cell Size', 'Cell Survival', 'Flow Cytometry', 'Fluorescent Dyes', 'Gene Silencing', 'HeLa Cells', 'Humans', 'Jurkat Cells', 'Magnaporthe', 'Microfluidics', 'Pressure', 'RNA', 'Saccharomyces cerevisiae', 'Spores, Fungal'] | 15,170,604 | [['A11.251.210'], ['G04.325'], ['G04.346'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['G05.308.203.374'], ['A11.251.210.190.400', 'A11.251.860... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Admission creatine kinase as a prognostic marker in acute myocardial infarction. | OBJECTIVES: To investigate the prognostic significance of creatine kinase (CK) in Pakistani patients suffering from acute myocardial infarction (AMI) and to find out if CK combined with troponin T (TnT) could be a better predictor for long-term adverse cardiac event.METHODS: One hundred and eighty six consecutive patie... | ['Creatine Kinase', 'Female', 'Fibrinolytic Agents', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Prognosis', 'Prospective Studies', 'Streptokinase', 'Thrombolytic Therapy', 'Troponin T'] | 20,201,171 | [['D08.811.913.696.640.150'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['E01.789'], ['E05.318.372.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Renal artery thrombosis and embolization associated with intravenous cocaine injection. | I have described a young man with unilateral renal artery thrombosis and embolization temporally related to the intravenous injection of cocaine. Patients with underlying vascular disease may be risking cardiovascular complications from recreational or medical use of cocaine. | ['Adult', 'Cocaine', 'Combined Modality Therapy', 'Embolism', 'Humans', 'Injections, Intravenous', 'Male', 'Renal Artery Obstruction', 'Substance-Related Disorders', 'Thrombosis'] | 3,603,118 | [['M01.060.116'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['E02.186'], ['C14.907.355.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['C12.777.419.775', 'C13.351.968.419.775', 'C14.907.137.727'], ['C25.775', 'F03.9... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Medical students' distress--quality, continuity and gender differences during a six-year medical programme. | Research observations suggest an increase in distress during the course of medical education, but it is not known whether this distress is chronic and persistent or episodic because follow-ups covering the whole training programme are lacking. We explored stress symptoms among undergraduate medical students (n = 110) a... | ['Education, Medical', 'Fatigue', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Mood Disorders', 'Prevalence', 'Sex Distribution', 'Sleep Wake Disorders', 'Stress, Psychological', 'Students, Medical', 'Surveys and Questionnaires'] | 16,707,294 | [['I02.358.399'], ['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['F03.600'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['I01.240.800', 'N01.22... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
A Novel Multistandard Compliant Hand Function Assessment Method Using an Infrared Imaging Device. | Many post-stroke patients suffer varying degrees of hand function and fine motor skills impairment. Both passive and active hand rehabilitation training are beneficial in improving the strength and dexterity of the hands. However, hand rehabilitation programs should be prescribed based on an accurate assessment of hand... | ['Disability Evaluation', 'Hand', 'Humans', 'Image Processing, Computer-Assisted', 'Motor Skills', 'Spectrophotometry, Infrared', 'Stroke Rehabilitation'] | 29,994,552 | [['E01.370.400'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['F02.808.260'], ['E05.196.712.726.676', 'E05.196.867.826.676'], ['E02.760.169.063.500.477.500', 'E02.831.477.500', 'H02.403.680.600.750.500', 'N02.421.784.511.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Pilot scale nanofiltration membrane separation for waste management in textile industry. | This paper presents the pilot scale membrane separation studies on dyehouse effluents of textile industry. Nanofiltration (NF) membranes which have 2 m2 of surface area were evaluated for membrane fouling on permeate flux and their suitability in separating COD, color and conductivity in relation to operating pressure ... | ['Coloring Agents', 'Conservation of Natural Resources', 'Industrial Waste', 'Micropore Filters', 'Pilot Projects', 'Textile Industry', 'Ultrafiltration', 'Waste Disposal, Fluid', 'Water Pollution, Chemical', 'Water Supply'] | 11,436,786 | [['D27.720.233'], ['J01.256', 'N06.230.080'], ['D20.944.420', 'N06.850.460.710.420'], ['E05.196.454.403', 'E07.560'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['J01.576.655.937'], ['E04.292.975', 'E05.196.454.807', 'G01.280.807', 'G02.263.807'], ['N06.850.780.200.800.800.890', '... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Malignancy in Solitary Thyroid Nodule. | This prospective study was done to find out the relative frequency of the malignancy in cold solitary thyroid nodules with other solitary thyroid nodules (hot and warm). This study was carried out in the Department of General Surgery and Otolaryngology-Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University (B... | ['Adenoma', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Bangladesh', 'Carcinoma', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Iodine Radioisotopes', 'Male', 'Middle Aged', 'Prospective Studies', 'Sex Factors', 'Thyroid Nodule', 'Thyroidectomy', 'Young Adult'] | 26,931,247 | [['C04.557.470.035'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.252.245.131'], ['C04.557.470.200'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01... | ['Diseases [C]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Sodium 4-Phenylbutyrate Attenuates Myocardial Reperfusion Injury by Reducing the Unfolded Protein Response. | BACKGROUND: The unfolded protein response (UPR) plays a pivotal role in ischemia-reperfusion (I/R) injury in various organs such as heart, brain, and liver. Sodium 4-phenylbutyrate (PBA) reportedly acts as a chemical chaperone that reduces UPR. In the present study, we evaluated the effect of PBA on reducing the UPR an... | ['Animals', 'Apoptosis', 'Disease Models, Animal', 'Gene Expression Regulation', 'Male', 'Mice, Inbred C57BL', 'Myocardial Contraction', 'Myocardial Infarction', 'Myocardial Reperfusion Injury', 'Myocardium', 'Phenylbutyrates', 'RNA, Messenger', 'Recovery of Function', 'Signal Transduction', 'Unfolded Protein Response'... | 27,909,014 | [['B01.050'], ['G04.146.954.035'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.308'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['G09.330.580', 'G11.427.494.570'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['C14.280.238.615',... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular mechanisms governing tumor-necrosis-factor-mediated regulation of plasminogen-activator inhibitor type-2 gene expression. | Plasminogen-activator inhibitor type 2 (PAI-2), a serine protease inhibitor involved in the regulation of urokinase-dependent proteolysis, is also implicated in the inhibition of tumor-necrosis-factor-(TNF)-mediated apoptosis. The PAI-2 gene is one of the most TNF-responsive genes known and is also highly induced by th... | ['Base Sequence', 'Binding Sites', 'DNA Probes', 'DNA-Binding Proteins', 'Gene Expression Regulation', 'Humans', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Nuclear Proteins', 'Plasminogen Activator Inhibitor 2', 'Promoter Regions, Genetic', 'Repressor Proteins', 'Sequence Analysis', 'Sequence Deletion', ... | 8,898,893 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['D12.776.260'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['E05.393.420.601.575'], ['D12.776.660'], ['D12.644.861.695.520'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Combined statistical analyses of peptide intensities and peptide occurrences improves identification of significant peptides from MS-based proteomics data. | Liquid chromatography-mass spectrometry-based (LC-MS) proteomics uses peak intensities of proteolytic peptides to infer the differential abundance of peptides/proteins. However, substantial run-to-run variability in intensities and observations (presence/absence) of peptides makes data analysis quite challenging. The m... | ['Analysis of Variance', 'Data Interpretation, Statistical', 'Mass Spectrometry', 'Peptides', 'Proteomics', 'Sensitivity and Specificity'] | 20,831,241 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['E05.196.566'], ['D12.644'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['E05.318.370.800',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Extracorporeal photochemotherapy in patients with cutaneous T-cell lymphoma: is clinical response predictable? | BACKGROUND: Extracorporeal photochemotherapy (ECP) has been accepted as a standard therapy in cutaneous T-cell lymphomas (CTCL), a category of lymphomas mainly resistant to conventional therapies. Approximately one half of patients demonstrate a reduction in skin affliction by at least 50% within 12 months of therapy a... | ['Aged', 'Aged, 80 and over', 'Female', 'Granzymes', 'Humans', 'L-Lactate Dehydrogenase', 'Lymphoma, T-Cell, Cutaneous', 'Male', 'Middle Aged', 'Neopterin', 'Photopheresis', 'Receptors, Interleukin-2', 'Solubility', 'Time Factors', 'beta 2-Microglobulin'] | 16,987,266 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D08.811.277.656.300.760.397', 'D08.811.277.656.959.350.397'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['C04.557.386.480.750.800', 'C15.604.515.569.480.750.800', 'C20.683.515.761.480.750.800'], ['M01.060.116... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Characterization of an immunoglobin cDNA clone containing the variable and constant regions for the MOPC 21 kappa light chain. | Nucleotide sequence analysis and restriction endonuclease mapping have been used to characterize a cDNA copy of immunoglobulin MOPC 21 Kappa mRNA clones in the bacterial plasmid pMB9. Three regions of the inserted cDNA of plasmid pL21-1 have been sequenced and match the known protein sequence at amino acid residues 1-2... | ['Amino Acid Sequence', 'Base Sequence', 'Binding Sites, Antibody', 'DNA Restriction Enzymes', 'DNA, Recombinant', 'Immunoglobulin Constant Regions', 'Immunoglobulin Light Chains', 'Immunoglobulin Variable Region', 'Immunoglobulin kappa-Chains', 'Immunoglobulins', 'Myeloma Proteins', 'Plasmids', 'RNA, Messenger'] | 100,766 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.060.425.079', 'G02.111.570.120.408', 'G12.122.232', 'G12.125'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['D13.444.308.460'], ['D12.776.124.486.485.538', 'D12.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Development of new anatomy reconstruction software to localize cardiac isochrones to the cardiac surface from the 12 lead ECG. | Non-invasive electrocardiographic imaging (ECGI) of the cardiac muscle can help the pre-procedure planning of the ablation of ventricular arrhythmias by reducing the time to localize the origin. Our non-invasive ECGI system, the cardiac isochrone positioning system (CIPS), requires non-intersecting meshes of the heart,... | ['Adult', 'Aged', 'Algorithms', 'Body Surface Potential Mapping', 'Computer Simulation', 'Diagnosis, Computer-Assisted', 'Female', 'Humans', 'Imaging, Three-Dimensional', 'Male', 'Middle Aged', 'Models, Anatomic', 'Models, Cardiovascular', 'Patient-Specific Modeling', 'Reproducibility of Results', 'Sensitivity and Spec... | 26,381,797 | [['M01.060.116'], ['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['E01.370.370.380.240.850.100', 'E01.370.405.240.850.100'], ['L01.224.160'], ['E01.158', 'L01.313.500.750.100.158'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['M01.060.116.630'], ['J01.897.280.500.545.129'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. | PURPOSE: Various studies have shown the importance of the GAIP interacting protein, COOH-terminus (GIPC, also known as Synectin) as a central adaptor molecule in different signaling pathways and as an important mediator of receptor stability. GIPC/Synectin is associated with different growth-promoting receptors such as... | ['Adaptor Proteins, Signal Transducing', 'Animals', 'Antineoplastic Agents', 'Cell Proliferation', 'Female', 'Gene Knockdown Techniques', 'Humans', 'Integrins', 'Mice', 'Mice, Nude', 'Oligopeptides', 'PDZ Domains', 'Pancreatic Neoplasms', 'Receptor, IGF Type 1', 'Signal Transduction'] | 19,509,165 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['D27.505.954.248'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.393.335.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543.750.705.408'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High incidence of focal segmental glomerulosclerosis in nephrotic syndrome of childhood. | In recent adult literature, there have been reports of an increasing incidence of focal segmental glomerulosclerosis (FSGS) among patients with nephrotic syndrome. To examine whether this observation is also relevant to the pediatric population we utilized our hospital computerized database to analyze the data on child... | ['Adolescent', 'Age Factors', 'Child', 'Child, Preschool', 'Female', 'Glomerulosclerosis, Focal Segmental', 'Humans', 'Incidence', 'Infant', 'Male', 'Nephrotic Syndrome'] | 10,100,283 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['M01.060.406.448'], ['C12.777.419.570.363.660', 'C13.351.968.419.570.363.640'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], [... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Chlamydia trachomatis antigen prevalence among pregnant women in West Virginia. | During 1990, more than 2,100 women who received prenatal care at one of four clinics which serve 11 West Virginia counties, were screened for chlamydial antigen. Overall, 5.6 percent of the women screened had positive antigen tests and 90 percent of these individuals were under the age of 25. The prevalence of chlamydi... | ['Adult', 'Antigens, Bacterial', 'Chlamydia Infections', 'Chlamydia trachomatis', 'Female', 'Humans', 'Mass Screening', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Prevalence', 'Risk Factors', 'Rural Population', 'Urban Population', 'West Virginia'] | 1,492,405 | [['M01.060.116'], ['D23.050.161'], ['C01.150.252.400.210.125', 'C01.150.252.734.301', 'C01.221.812.281.301', 'C01.778.281.301', 'C12.294.668.281.301', 'C13.351.500.711.281.301'], ['B03.440.190.190.190.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Studies on the toxicity of gambogic acid in rats. | AIM: To study the chronic toxicity of gambogic acid (GA), the major active ingredient of gamboges, a brownish to orange resin extracted from the Garcinia hanburyi (family Guttiferae) in Southeast Asia, using Sprague-Dawley rat as an animal model and provide further theoretical support for clinical applications of this ... | ['Animals', 'Antineoplastic Agents, Phytogenic', 'Behavior, Animal', 'Blood Cell Count', 'Body Weight', 'Female', 'Garcinia', 'Kidney', 'Liver', 'Liver Function Tests', 'Male', 'Myocardium', 'Organ Size', 'Rats', 'Rats, Sprague-Dawley', 'Xanthones'] | 18,384,990 | [['B01.050'], ['D27.505.954.248.179'], ['F01.145.113'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['B0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Seizure activity affects neuroglial Kv1 channel immunoreactivities in the gerbil hippocampus. | In order to confirm the species-specific distribution of voltage-gated K(+) (Kv) channels and the definitive relationship between their immunoreactivities and seizure activity, we investigated Kv1 channel immunoreactivities in the hippocampus of seizure resistant (SR) and seizure sensitive (SS) gerbils. There was disti... | ['Animals', 'Cell Count', 'Gerbillinae', 'Glial Fibrillary Acidic Protein', 'Hippocampus', 'Immunohistochemistry', 'Neuroglia', 'Parvalbumins', 'Rats', 'Rats, Sprague-Dawley', 'Seizures', 'Shaker Superfamily of Potassium Channels'] | 17,397,809 | [['B01.050'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['B01.050.150.900.649.313.992.635.300'], ['D05.750.078.593.400', 'D12.776.220.475.400'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The C domain of netrin UNC-6 silences calcium/calmodulin-dependent protein kinase- and diacylglycerol-dependent axon branching in Caenorhabditis elegans. | Second messenger systems mediate neuronal responses to extracellular factors that elicit axon branching, turning, and guidance. We found that mutations in Caenorhabditis elegans that affect components of second messenger systems, a G-protein subunit, phospholipase Cbeta, diacylglycerol (DAG) kinase, and calcium/calmodu... | ['Alleles', 'Animals', 'Animals, Genetically Modified', 'Axons', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Calcium-Calmodulin-Dependent Protein Kinase Type 2', 'Calcium-Calmodulin-Dependent Protein Kinases', 'Diacylglycerol Kinase', 'Diglycerides', 'GTP-Binding Protein alpha Subunits, Gq-G11', 'Helm... | 11,896,167 | [['G05.360.340.024.340.030'], ['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['D08.811.913.696.620.682.700.125.200', 'D12.644.360.100.200', 'D12.776.476.100.200'], ['D08.811.913.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identifying predictors of central nervous system disease in solid organ transplant recipients with cryptococcosis. | BACKGROUND: Cerebrospinal fluid (CSF) analysis is often deferred in patients with cryptococcal disease, particularly in the absence of neurologic manifestations. We sought to determine whether a subset of solid organ transplant (SOT) recipients with high likelihood of central nervous system (CNS) disease could be ident... | ['Adult', 'Antigens, Fungal', 'Central Nervous System Diseases', 'Chi-Square Distribution', 'Cohort Studies', 'Cryptococcosis', 'Drug Therapy, Combination', 'Female', 'Humans', 'Immunosuppressive Agents', 'Likelihood Functions', 'Male', 'Middle Aged', 'Organ Transplantation', 'Postoperative Complications', 'Predictive ... | 20,061,921 | [['M01.060.116'], ['D23.050.202'], ['C10.228'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C01.150.703.248'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.69... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Restriction mapping of a chlorobenzoate degradative plasmid and molecular cloning of the degradative genes. | The genes for the degradation of 3-chlorobenzoic acid ( 3Cba ) are present in a 110-kb plasmid pAC27 . A circular map is established using the restriction endonucleases EcoRI, HindIII and Bg/II. The map is derived from the results obtained by partial restriction digestion, complete single and double restriction digesti... | ['Chlorobenzoates', 'Chromosomes, Bacterial', 'Cloning, Molecular', 'DNA Restriction Enzymes', 'DNA, Bacterial', 'Genes, Bacterial', 'Nucleic Acid Hybridization', 'Plasmids', 'Pseudomonas', 'Recombination, Genetic'] | 6,327,465 | [['D02.241.223.100.200', 'D02.455.426.559.389.127.250'], ['A11.284.187.190', 'A20.812', 'G05.360.162.190'], ['E05.393.220'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['D13.444.308.212'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['E0... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport. | The thick ascending limb (TAL) of Henle's loop drives paracellular Na+, Ca2+, and Mg2+ reabsorption via the tight junction (TJ). The TJ is composed of claudins that consist of four transmembrane segments, two extracellular segments (ECS1 and -2), and one intracellular loop. Claudins interact within the same (cis) and o... | ['Animals', 'Claudins', 'HEK293 Cells', 'Humans', 'Loop of Henle', 'Magnesium', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Rats, Sprague-Dawley', 'Sodium', 'Tight Junctions'] | 28,028,216 | [['B01.050'], ['D12.776.543.940.200'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453.736.560.610'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.136.50... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Crystal arthritis: a clinician's view. | Arthritis, which can be acute, chronic or asymptomatic, is caused by a variety of crystal deposition in joints. The three main types of crystal arthritis are monosodium urate (gout), calcium pyrophosphate dihydrate, and calcium phosphate (usually hydroxyapatite). A clinical approach to diagnosis and management. | ['Adrenal Cortex Hormones', 'Adult', 'Aged', 'Anti-Inflammatory Agents, Non-Steroidal', 'Arthritis', 'Arthritis, Gouty', 'Calcium Pyrophosphate', 'Chondrocalcinosis', 'Colchicine', 'Crystallization', 'Diagnosis, Differential', 'Gout', 'Humans', 'Hydroxyapatites', 'Osteoarthritis', 'Periarthritis', 'Uric Acid'] | 1,805,773 | [['D06.472.040'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['C05.550.114'], ['C05.550.114.423.410', 'C05.550.354.500.500', 'C05.799.414.410', 'C16.320.565.798.368.410', 'C18.452.648.798.368.410'], ['D01.029.260.700.675.374.075.150', 'D01.02... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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