Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Surface replacement of the hip with the Tharies system. Two to five-year results. | The two to five-year clinical results of 200 Tharies surface replacements were comparable to those of conventional total hip replacement. The incidence of systemic complications, dislocations, and sepsis was low. There were ten cases of aseptic and one case of septic loosening. Nine minor secondary procedures were requ... | ['Adolescent', 'Adult', 'Aged', 'Female', 'Follow-Up Studies', 'Gait', 'Hip Joint', 'Hip Prosthesis', 'Humans', 'Joint Diseases', 'Male', 'Middle Aged', 'Movement', 'Postoperative Complications', 'Radiography'] | 7,276,044 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['A02.835.583.411'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550'], ['M01.060.116.630'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The development of future thinking: young children's ability to construct event sequences to achieve future goals. | Previous studies suggest that the ability to think about and act on the future emerges between 3 and 5 years of age. However, it is unclear what underlying processes change during the development of early future-oriented behavior. We report three experiments that tested the emergence of future thinking ability through ... | ['Age Factors', 'Child Development', 'Child, Preschool', 'Female', 'Forecasting', 'Goals', 'Humans', 'Male', 'Memory, Short-Term', 'Thinking'] | 24,786,765 | [['N05.715.350.075', 'N06.850.490.250'], ['F01.525.200', 'G07.345.374.750'], ['M01.060.406.448'], ['I01.320'], ['F01.658.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.407'], ['F02.463.785']] | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Firefly luciferase ATP assay as a screening method for bacteriuria. | A rapid (15 min) test for bacteriuria based on firefly luciferase analysis of bacterial ATP has been evaluated in 2,018 clinical urine specimens. The test procedure involves removal of nonbacterial ATP by treatment of urine with Triton X-100 and apyrase, extraction of bacterial ATP by boiling, and bioluminescent analys... | ['Adenosine Triphosphate', 'Animals', 'Bacteriological Techniques', 'Bacteriuria', 'Coleoptera', 'False Negative Reactions', 'False Positive Reactions', 'Humans', 'Luciferases', 'Luminescent Measurements', 'Mass Screening', 'Nitrites'] | 6,339,544 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['E01.370.225.875.150', 'E05.200.875.150'], ['C01.915.219', 'C12.777.892.219', 'C13.351.968.892.219'], ['B01.050.500.131.617.720.500.500.375'], ['E01.354.340'], ['E01.354.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Adverse events in therapeutic apheresis: a single center survey of various therapies. | The aim of the study was to review the adverse events associated with various treatment modalities performed in a single apheresis facility. A total of 854 sessions with 10 types of apheresis therapies were performed and 154 (18.0%) adverse events were observed over a four-year period. Of the adverse events, 77 were re... | ['Blood Component Removal', 'Humans', 'Japan', 'Leukapheresis', 'Nausea', 'Time Factors'] | 21,118,368 | [['E02.120'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['E02.095.160.570', 'E02.120.285.570', 'E02.120.527.570', 'E05.200.500.363.171.570', 'E05.242.363.171.570'], ['C23.888.821.712'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Counseling: establishing a culture of forgiveness. | Counseling "problem employees" can be a painful experience for everyone involved. The counseling process often fails because forgiveness is not a part of organizational culture in the United States. This author stresses the need for a forgiveness plan that will enable employees to recommit to their jobs | ['Counseling', 'Employee Discipline', 'Humans', 'Interprofessional Relations', 'Organizational Culture', 'Personnel Management'] | 17,822,645 | [['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['N04.452.677.358'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['N04.452.606'], ['N04.452.677']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Miniaturized protein arrays: Model and experiment. | Nanobiolithography techniques have the ability to fabricate structures of biomolecules as small as ?40 nm. However, very few examples of working biosensors of these sizes have been demonstrated. These examples use substrates like Gold and Silicon, that are advantageous for fabrication purposes, but present disadvantage... | ['Binding Sites', 'Biosensing Techniques', 'Fluorescent Dyes', 'Gold', 'Models, Theoretical', 'Protein Array Analysis', 'Silicon'] | 21,411,306 | [['G02.111.570.120'], ['E05.601.043'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['E05.599'], ['E05.588.570.700', 'E05.601.680'], ['D01.268.513.937']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pancreas transplantation: long-term results. | The rationale behind pancreatic transplantation is to provide a self-regulated, endogenous source of insulin and other islet hormones, thus restoring normal metabolism with the ultimate goals of prevention, stabilization or reversal of secondary degenerative complications. We report clinical and metabolic data of 8 pa... | ['Adult', 'Diabetes Mellitus, Type 1', 'Diabetic Neuropathies', 'Diabetic Retinopathy', 'Duodenum', 'Follow-Up Studies', 'Humans', 'Kidney Transplantation', 'Pancreas Transplantation', 'Pancreatic Ducts'] | 10,147,641 | [['M01.060.116'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C10.668.829.300', 'C19.246.099.937'], ['C11.768.257', 'C14.907.320.382', 'C19.246.099.500.382'], ['A03.556.124.684.124', 'A03.556.875.249'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sources of sampling variation in saliva cortisol in dogs. | The main advantage of collecting saliva cortisol as opposed to plasma cortisol is that it is non-invasive and therefore it is now widely used in stress measurement studies on farm animals and dogs. Although a plasma cortisol response to handling associated with blood collection generally occurs at 3 min from the commen... | ['Animals', 'Dogs', 'Female', 'Hydrocortisone', 'Male', 'Observer Variation', 'Reproducibility of Results', 'Saliva', 'Specimen Handling', 'Time Factors'] | 12,893,165 | [['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['A12.200.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
V. Multi-level analysis of cortical neuroanatomy in Williams syndrome. | The purpose of a neuroanatomical analysis of Williams Syndrome (WMS) brains is to help bridge the knowledge of the genetics of this disorder with the knowledge on behavior. Here, we outline findings of cortical neuroanatomy at multiple levels. We describe the gross anatomy with respect to brain shape, cortical folding,... | ['Adult', 'Amygdala', 'Behavior', 'Brain Chemistry', 'Cell Count', 'Cell Size', 'Cerebral Cortex', 'Elastin', 'Functional Laterality', 'Humans', 'Infant', 'Lim Kinases', 'Male', 'Neurons', 'Organ Size', 'Protein Kinases', 'Williams Syndrome'] | 10,953,235 | [['M01.060.116'], ['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['F01.145'], ['G02.111.150', 'G03.185'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.325'], ['A08.186.211.200.885.287.500'], ['D05.750.078.421', 'D12.776.860.300.350'], ['F02.830.297.425', 'G11.561.225.425'], [... | ['Named Groups [M]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[A historical skull specimen in Leipheim with evidence of penetrating injury]. | Report on a skull, which was found in a dredged pit together with 20 incomplete skeletons. There were two sharp-edged lesions without signs of regeneration, probable caused by a sharp object like a sword. Relics found at the scene led to the presumption, that the skull belonged to a victim of peasant's war, which happe... | ['Civil Disorders', 'Germany', 'History, 16th Century', 'Humans', 'Male', 'Occipital Bone', 'Skull Fractures', 'Wounds, Stab'] | 8,546,562 | [['I01.880.735.140'], ['Z01.542.315'], ['K01.400.475.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.572'], ['C10.900.300.918', 'C26.404.750', 'C26.915.300.745'], ['C26.986.950']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
131I-meta-iodobenzylguanidine in diagnosis and treatment of neuroblastoma. | 131I MIBG is taken up and stored by neural crest tumors, essentially pheochromocytoma and neuroblastoma. MIBG diagnosis in neuroblastoma has been attempted with the following results. 205 total body scintigrams were performed in 60 patients with neuroblastoma with doses of MIBG ranging from 0.5 to 1 mCi. 52 were positi... | ['3-Iodobenzylguanidine', 'Adolescent', 'Adrenal Gland Neoplasms', 'Bone Marrow', 'Child', 'Child, Preschool', 'Drug Administration Schedule', 'Follow-Up Studies', 'Humans', 'Infant', 'Iodine Radioisotopes', 'Iodobenzenes', 'Neuroblastoma', 'Pheochromocytoma', 'Radionuclide Imaging', 'Radiotherapy Dosage'] | 3,359,053 | [['D02.078.370.510', 'D02.455.426.559.389.454.300', 'D02.455.526.581.496.300'], ['M01.060.057'], ['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['A15.382.216'], ['M01.060.406'], ['M01.060.406.448'], ['E02.319.283'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The lived experience of peripheral neuropathy after solid organ transplant. | BACKGROUND: The immunosuppressants required after transplant cause peripheral neuropathy with an incidence of 10% to 60%. Peripheral neuropathy adversely affects health-related quality of life in other populations.OBJECTIVE: To describe the lived experience of peripheral neuropathy after solid organ transplant.DESIGN: ... | ['Female', 'Humans', 'Immunosuppressive Agents', 'Interviews as Topic', 'Male', 'Middle Aged', 'Organ Transplantation', 'Peripheral Nervous System Diseases', 'Quality of Life'] | 22,951,505 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['M01.060.116.630'], ['E04.936.450'], ['C10.668.829'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Acetylcholine-induced ex vivo ATP release from the human nasal mucosa. | OBJECTIVE: The present study aimed at investigating ATP release in response to acetylcholine (Ach) and pharmacologically elucidating the intracellular signal transduction pathway of this reaction in an ex vivo experiment.METHODS: The inferior turbinate mucosa was collected from 21 patients with chronic hypertrophic rhi... | ['Acetylcholine', 'Adenosine Triphosphate', 'Adolescent', 'Adult', 'Aged', 'Anti-Ulcer Agents', 'Atropine', 'Calcium', 'Carbenoxolone', 'Cholinergic Agonists', 'Connexins', 'Enzyme Inhibitors', 'Female', 'Humans', 'Macrolides', 'Male', 'Middle Aged', 'Muscarinic Antagonists', 'Nasal Mucosa', 'Nerve Tissue Proteins', 'P... | 27,692,399 | [['D02.092.211.111'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.483.203'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Variable patterned pudendal nerve stimuli improves reflex bladder activation. | We evaluated variable patterns of pudendal nerve (PN) stimuli for reflex bladder excitation. Reflex activation of the bladder has been demonstrated previously with 20-33 Hz continuous stimulation of PN afferents. Neuronal circuits accessed by afferent mediated pathways may respond better to physiological patterned stim... | ['Animals', 'Cats', 'Electric Stimulation', 'Electric Stimulation Therapy', 'Male', 'Muscle Contraction', 'Muscle, Smooth', 'Pressure', 'Reflex', 'Urinary Bladder'] | 18,403,282 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.723.402'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['G11.427.494'], ['A02.633.570', 'A10.690.467'], ['G01.374.715'], ['E01.370.376.550.650', 'E01.370.600.550.650', 'F02.830.702', 'G11.561.731'], ['A05.810.890']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peptic ulcer perforation: a complication of double contrast barium meal examination. | This is a case report of peptic ulcer perforation as a complication of double contrast Barium meal examination in the presence of gastric outlet obstruction. | ['Aged', 'Barium Sulfate', 'Enema', 'Female', 'Humans', 'Peptic Ulcer Perforation', 'Pyloric Stenosis', 'Stomach Ulcer'] | 2,799,373 | [['M01.060.116.100'], ['D01.103.075', 'D01.875.800.800.850.075'], ['E02.319.347'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.275.800.698', 'C06.405.748.586.698'], ['C06.405.748.340.690'], ['C06.405.469.275.800.849', 'C06.405.748.586.849']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein. | The zinc finger antiviral protein (ZAP) is a mammalian host restriction factor that inhibits the replication of a variety of RNA viruses, including retroviruses, alphaviruses and filoviruses, through interaction with the ZAP-responsive elements (ZRE) in viral RNA, and recruiting the exosome to degrade RNA substrate. He... | ['Adolescent', 'Adult', 'Animals', 'Carrier Proteins', 'DNA Replication', 'DNA, Viral', 'Down-Regulation', 'Female', 'Hep G2 Cells', 'Hepatitis B virus', 'Hepatitis B, Chronic', 'Hepatocytes', 'Humans', 'Male', 'Peptide Fragments', 'Protein Interaction Domains and Motifs', 'Protein Isoforms', 'RNA Stability', 'RNA, Vir... | 23,853,601 | [['M01.060.057'], ['M01.060.116'], ['B01.050'], ['D12.776.157'], ['G02.111.225', 'G05.226'], ['D13.444.308.568'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925.440... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A cognitive and physical performance assessment of retirees entering a continuing care retirement community: the Moorings Assessment Protocol. | Moorings Park Continuing Care Retirement Community (CCRC) screened 267 applicants (115 males; 152 females; mean age 80.22 years) using the Mini-Mental State Examination (MMSE), the 7-Minute Screen, the Geriatric Depression Scale (GDS), and the Physical Performance Test (PPT). They compared mean scores across admission/... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Dementia', 'Female', 'Florida', 'Geriatric Assessment', 'Housing for the Elderly', 'Humans', 'Male', 'Neuropsychological Tests', 'Psychiatric Status Rating Scales', 'Psychomotor Performance'] | 12,708,221 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380', 'F03.615.400'], ['Z01.107.567.875.750.350'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['J03.340.260', 'N01.224.791.400.410... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Phenomena a... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Knowledge and involvement of nurses regarding health policy development in Thailand. | The purpose of this descriptive study was to explain the levels of knowledge about and involvement in national health policy development by nurses in Thailand. The study used quantitative and qualitative means to gather data about the topic from two groups of professional nurses: 2121 nurses who worked in hospitals aro... | ['Adult', 'Clinical Competence', 'Female', 'Health Policy', 'Humans', 'Knowledge', 'Leadership', 'Male', "Nurse's Role", 'Public Policy', 'Qualitative Research', 'Reproducibility of Results', 'Surveys and Questionnaires', 'Thailand'] | 20,602,695 | [['M01.060.116'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.468'], ['F01.752.609'], ['F01.829.316.616.625.450', 'N05.300.100.337'], ['I01.655.500.608', 'I01.880.604.825.608', 'N03.6... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Humanities [K]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Membrane structure and interactions of peptide hormones with model lipid bilayers. | In this work, the behavior of the neurohypophyseal hormones and their selected analogs was studied in the presence of membrane models in an attempt to correlate their activities with a distinct behavior at a level of peptide-lipid interactions. The influence of the peptides studied on the lipid acyl chain order was det... | ['Calorimetry, Differential Scanning', 'Cell Membrane', 'Cell Membrane Structures', 'Hydrophobic and Hydrophilic Interactions', 'Lipid Bilayers', 'Liposomes', 'Peptide Hormones', 'Pituitary Hormones, Posterior', 'Protein Binding', 'Protein Conformation', 'Protein Structure, Secondary'] | 22,824,299 | [['E05.196.131.310', 'E05.196.370.310'], ['A11.284.149'], ['A11.284.149.165'], ['G02.409'], ['D10.570.510', 'J01.637.087.500.510'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['D06.472.699', 'D12.644.548'], ['D06.472.699.631.692', 'D12.644.548.691.692'], ['G02.111.679', 'G03.808']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation. | Inhibition of the microtubule (MT) motor protein Eg5 results in a mitotic arrest due to the formation of monopolar spindles, making Eg5 an attractive target for anti-cancer therapies. However, Eg5-independent pathways for bipolar spindle formation exist, which might promote resistance to treatment with Eg5 inhibitors. ... | ['Aurora Kinase A', 'Genome-Wide Association Study', 'HeLa Cells', 'Humans', 'Kinesin', 'Microtubules', 'Mitosis', 'RNA, Small Interfering', 'Spindle Apparatus'] | 27,354,041 | [['D08.811.913.696.620.682.700.103.500', 'D12.776.167.049.500'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N06.850.520.470.500'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Recombinant PBP2a of methicillin-resistant S. aureus formulation in Alum and Montanide ISA266 adjuvants induced cellular and humoral immune responses with protection in Balb/C mice. | Staphylococcus aureus is an important cause of both hospital and community acquired infections worldwide. S.aureus can develop multidrug resistance; thus, immunotherapy can be a rational alternative. High level â-lactam resistance of S. aureus has been attributed to the penicillin binding protein 2a (PBP2a). In this st... | ['Adjuvants, Pharmaceutic', 'Alum Compounds', 'Animals', 'Antibodies, Bacterial', 'Bacterial Proteins', 'Drug Compounding', 'Female', 'Humans', 'Immunity, Cellular', 'Immunity, Humoral', 'Immunoglobulin G', 'Interleukin-17', 'Interleukin-4', 'Mannitol', 'Methicillin-Resistant Staphylococcus aureus', 'Mice', 'Mice, Inbr... | 31,874,228 | [['D26.650.064', 'D27.720.744.064'], ['D01.056.025', 'D01.875.800.800.850.025'], ['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D12.776.097'], ['E05.916.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.050.400'], ['G12.450.050.420'], ['D12.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inducible nitric oxide synthase appears and is co-expressed with the neuronal isoform in interneurons of the rat hippocampus after transient ischemia induced by middle cerebral artery occlusion. | The hippocampus (dentate gyrus DG plus Cornu Ammonis, CA) is vulnerable to neuropathological events such as ischemia. The DG is a region where neurogenesis takes place and it has been demonstrated that ischemia stimulates neurogenesis. Nitric oxide (NO) plays a major role in ischemic damage evolution and increases in r... | ['Animals', 'Gene Expression Regulation, Enzymologic', 'Hippocampus', 'Infarction, Middle Cerebral Artery', 'Interneurons', 'Ischemic Attack, Transient', 'Male', 'Nitric Oxide Synthase Type I', 'Nitric Oxide Synthase Type II', 'Rats', 'Rats, Wistar'] | 18,436,211 | [['B01.050'], ['G05.308.320'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['C10.228.140.300.150.477.200.450', 'C10.228.140.300.510.200.387', 'C10.228.140.300.775.200.200.450', 'C14.907.253.092.477.200.450', 'C14.907.253.560.200.387', 'C14.907.253.855.200.200.450', 'C23.550.513.355.250.200.450', 'C23.55... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Behavioural and social characteristics of subjects with repeated sexually transmitted diseases. | A case-control study was performed in order to assess risk factors for repeated sexually transmitted diseases. The study comprised 101 patients who had had sexually transmitted diseases 3 or more times during their lives and 182 controls who had no history of sexually transmitted disease. The subjects all attended the ... | ['Adult', 'Case-Control Studies', 'Humans', 'Middle Aged', 'Recurrence', 'Risk Factors', 'Sexually Transmitted Diseases', 'Social Behavior'] | 10,721,833 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.291.937'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.72... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cytoplasmic and nuclear input virus RNPs in influenza virus-infected cells. | Chicken fibroblasts and MDCK cells were infected with influenza virus labelled with either 3H-uridine or 14C-amino acids, and the location in infected cells and properties of input virus-labelled structures were studied. Input virus RNA and protein were found in the cytoplasm of nuclei 1 h p.i. A part of the intranucle... | ['Animals', 'Cell Line', 'Cell Nucleus', 'Chick Embryo', 'Cytoplasm', 'Dogs', 'Fibroblasts', 'Influenza A virus', 'Kidney', 'Nucleoproteins', 'Peptides', 'Ribonucleoproteins', 'Viral Proteins', 'Virus Replication'] | 541,671 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sickle Cell Trait, Rhabdomyolysis, and Mortality among U.S. Army Soldiers. | BACKGROUND: Studies have suggested that sickle cell trait elevates the risks of exertional rhabdomyolysis and death. We conducted a study of sickle cell trait in relation to these outcomes, controlling for known risk factors for exertional rhabdomyolysis, in a large population of active persons who had undergone labora... | ['Adolescent', 'Adult', 'African Americans', 'Hemoglobin, Sickle', 'Humans', 'Male', 'Military Personnel', 'Physical Exertion', 'Proportional Hazards Models', 'Retrospective Studies', 'Rhabdomyolysis', 'Risk Assessment', 'Sickle Cell Trait', 'Tobacco Use', 'United States', 'Young Adult'] | 27,518,662 | [['M01.060.057'], ['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['D12.776.124.400.463.588', 'D12.776.422.316.762.426.588'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.625'], ['G11.427.683'], ['E05.318.740.500.700', 'E05.318.740.600.700', 'E05.318.740.750.725', 'E05.318.740.998.825', 'E05.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Diagnostic problems of purulent meningitis in children in general practice]. | Previous investigations have demonstrated that considerable problems may exist in the diagnosis of purulent meningitis (PM) in general practice. Referrals from general practitioners/duty roster doctors concerning 97 children discharged the diagnosis of PM were reviewed retrospectively. The patients were subdivided into... | ['Adolescent', 'Anti-Bacterial Agents', 'Child', 'Child, Preschool', 'Denmark', 'Family Practice', 'Female', 'Humans', 'Infant', 'Male', 'Meningitis', 'Referral and Consultation', 'Suppuration'] | 2,008,759 | [['M01.060.057'], ['D27.505.954.122.085'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.542.816.124'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C10.228.614'], ['N04.452.758.849'], ['C01.830', 'C23.550.470.756']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
MicroRNA-106b overexpression alleviates inflammation injury of cardiac endothelial cells by targeting BLNK via the NF-êB signaling pathway. | We aim to investigate whether microRNA-106b (miR-106b) affects the inflammation injury of cardiac endothelial cells (ECs) by targeting B-cell linker (BLNK) via the NF-êB signaling pathway. Human cardiac microvascular endothelial cells (HCMECs) were assigned into the control, hypoxia/reoxygenation (H/R), negative contro... | ['Adaptor Proteins, Signal Transducing', 'Apoptosis', 'Blotting, Western', 'Cell Proliferation', 'Cells, Cultured', 'Computational Biology', 'Endothelial Cells', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Inflammation', 'MicroRNAs', 'NF-kappa B', 'Signal Transduction'] | 29,144,032 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['H01.158.273.180', 'L01.313.124'], ['A11.436.275'], ['E05.478.566.350.170', 'E05.478... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Clinical trial with an experimental taurine derivative, taltrimide, in epileptic patients. | The antiepileptic effect, effects on EEG, and tolerability of taltrimide, a new taurine derivative, were studied in this open clinical trial in 27 patients with severe epilepsy resistant to conventional drugs. After the 2-week control phase, taltrimide was given in gradually increasing doses up to 4.0 g/day--this dose ... | ['Adult', 'Carbamazepine', 'Clinical Trials as Topic', 'Clonazepam', 'Electroencephalography', 'Epilepsy', 'Humans', 'Indoles', 'Phenobarbital', 'Phenytoin', 'Phthalimides', 'Valproic Acid'] | 3,081,338 | [['M01.060.116'], ['D03.633.300.240.127'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['D03.633.100.079.080.070.150'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473'], ['D03.383.742.698.253.650'], ['D03... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Frequency and clinical characteristics of chronic daily headache in an outpatient clinic setting. | BACKGROUND AND PURPOSE: Chronic daily headache (CDH) is not a diagnosis but a category that includes many disorders representing primary and secondary headaches. According to the International Classification of Headache Disorders, 2nd edition (ICHD-II), CDH is defined as headache which occurs more often than 15 days pe... | ['Adult', 'Analgesics', 'Antidepressive Agents, Tricyclic', 'Female', 'Headache Disorders', 'Headache Disorders, Secondary', 'Health Status', 'Humans', 'Male', 'Middle Aged', 'Migraine Disorders', 'Poland', 'Prevalence', 'Serotonin Uptake Inhibitors', 'Severity of Illness Index', 'Sex Distribution', 'Tension-Type Heada... | 21,384,288 | [['M01.060.116'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['D27.505.954.427.700.122.055'], ['C10.228.140.546'], ['C10.228.140.546.699'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.228.140.546.399.750'], ['Z01.542.248.679... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Electron-microscopic study of sclerodermatous chronic graft-versus-host disease. | BACKGROUND: Sclerodermatous chronic graft-versus-host disease (SC-GVHD) resembles systemic scleroderma (SSD) closely, both clinically and histologically. Our purpose was to try to define the morphologic differences of collagen fibers between SC-GVHD and SSD.MATERIALS AND METHODS: Using electron microscopy, we compared ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Chronic Disease', 'Collagen', 'Diagnosis, Differential', 'Female', 'Graft vs Host Disease', 'Humans', 'Microscopy, Electron', 'Middle Aged', 'Scleroderma, Systemic', 'Skin'] | 8,970,842 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.291.500'], ['D05.750.078.280', 'D12.776.860.300.250'], ['E01.171'], ['C20.452'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402', 'E05.595.402'], ['M01.060.116.630'], ['C17.300.799', 'C17.800.784'], ['A17.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Stimuli-Responsive Pure Protein Organogel Sensors and Biocatalytic Materials. | Utilizing protein chemistry in organic solvents has important biotechnology applications. Typically, organic solvents negatively impact protein structure and function. Immobilizing proteins via cross-links to a support matrix or to other proteins is a common strategy to preserve the native protein function. Recently, w... | ['Biocatalysis', 'Ethylene Glycol', 'Serum Albumin, Bovine'] | 31,820,639 | [['G02.111.086', 'G02.130.500', 'G03.105'], ['D02.033.455.250.268'], ['D12.776.034.841.540', 'D12.776.124.727.875']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Activity of pentamidine-loaded poly (D,L-lactide) nanoparticles against Leishmania infantum in a murine model. | The activity of pentamidine-loaded poly(D,L-lactide) nanoparticles was compared, by determination of median effective doses (ED50), to that of free pentamidine in a murine model of visceral leishmaniasis induced by Leishmania infantum. BALB/c mice were infected intravenously on day O with promastigotes and then treated... | ['Animals', 'Antiprotozoal Agents', 'Delayed-Action Preparations', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Leishmania infantum', 'Leishmaniasis, Visceral', 'Mice', 'Mice, Inbred BALB C', 'Pentamidine', 'Polyesters'] | 9,587,601 | [['B01.050'], ['D27.505.954.122.250.100'], ['D26.255.210', 'E02.319.300.253'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.268.475.868.488.325'], ['C01.610.752.300.500.510', 'C01.920.813.510'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Age related changes in the glycosidases of chick embryo eye tissues]. | Studies have been made on the activity of glycosidases from eye tissues of developing chick embryos and adult hens. The enzymes of carbohydrates metabolism (hyaluronidase, beta-glycosidase and beta-galactosidase) from the sclera, cornea and ciliary body were examined. It was demonstrated that the distribution of glycos... | ['Aging', 'Animals', 'Chick Embryo', 'Chickens', 'Eye', 'Galactosidases', 'Glucosidases', 'Glycoside Hydrolases', 'Hyaluronoglucosaminidase'] | 941,574 | [['G07.345.124'], ['B01.050'], ['A13.350.150', 'A16.331.200'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['A01.456.505.420', 'A09.371'], ['D08.811.277.450.410'], ['D08.811.277.450.420'], ['D08.811.277.450'], ['D08.811.277.450.529', 'D08.811.520.241.700.675']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Negative cross-reactivity of rabbit anti-Malassezia furfur antibodies with other yeasts. | Anti-Malassezia furfur monospecific polyclonal antibodies was produced by repeated immunization of rabbit with Malassezia furfur yeast cells mixed with Freud adjuvant. The antibody titres of respective rabbit's serum samples prior to and after each immunization against M. furfur were assayed by indirect immunofluoresce... | ['Animals', 'Antibodies, Fungal', 'Cross Reactions', 'Fluorescent Antibody Technique', 'Humans', 'Malassezia', 'Rabbits', 'Tinea Versicolor', 'Yeasts'] | 17,191,397 | [['B01.050'], ['D12.776.124.486.485.114.179', 'D12.776.124.790.651.114.179', 'D12.776.377.715.548.114.179'], ['G12.122.281'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.30... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Half-molar sodium-lactate: The osmotic agent we are looking for?]. | Intracranial hypertension (ICH) is the most important modifiable factor with predictive negative value in brain injury patients. Osmotherapy is the most important first level specific measure in the treatment of ICH. Mannitol 20%, and 3, 7.5, 10, and 23% hypertonic sodium chloride are the most commonly used osmotic age... | ['Brain Injuries', 'Humans', 'Intracranial Hypertension', 'Mannitol', 'Sodium', 'Sodium Lactate'] | 26,655,973 | [['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.631'], ['D02.033.800.609', 'D09.853.609'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850', 'D01.552.547.725'], ['D02.241.511.459.800']] | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
First detection of porcine circovirus type 3 on commercial pig farms in Poland. | Porcine circovirus type 3 (PCV3) is a novel circovirus species recently discovered in USA and China in cases of porcine dermatitis and nephropathy syndrome, reproductive failure, respiratory disease and multisystemic inflammation. This study reports on the first identification of PCV3 in Europe, in serum from pigs from... | ['Animals', 'Circoviridae Infections', 'Circovirus', 'Farms', 'Poland', 'Real-Time Polymerase Chain Reaction', 'Swine', 'Swine Diseases'] | 28,649,803 | [['B01.050'], ['C01.925.256.200'], ['B04.280.120.150'], ['J01.040.372', 'J03.540.150'], ['Z01.542.248.679'], ['E05.393.620.500.706'], ['B01.050.150.900.649.313.500.880'], ['C22.905']] | ['Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
An amelogenin mutation leads to disruption of the odontogenic apparatus and aberrant expression of Notch1. | BACKGROUND: Amelogenins are highly conserved proteins secreted by ameloblasts in the dental organ of developing teeth. These proteins regulate dental enamel thickness and structure in humans and mice. Mice that express an amelogenin transgene with a P70T mutation (TgP70T) develop abnormal epithelial proliferation in an... | ['Ameloblasts', 'Amelogenesis', 'Amelogenin', 'Animals', 'Blotting, Western', 'Cell Proliferation', 'Dental Enamel', 'Enamel Organ', 'Epithelial Cells', 'Exons', 'Female', 'Gene Expression Regulation, Developmental', 'Genotype', 'Male', 'Mice', 'Mice, Knockout', 'Mice, Transgenic', 'Molar', 'Point Mutation', 'Proline',... | 20,923,441 | [['A11.436.107'], ['G07.345.500.325.377.750.190'], ['D12.776.231.500'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.161.750', 'G07.345.249.410.750'], ['A14.549.167.900.255'], ['A14.549.167.900.720.265'], ['A11.436'], ['G05.360.340.024.340.137.2... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
AMOTL2 interaction with TAZ causes the inhibition of surfactant proteins expression in lung cells. | BACKGROUND: TAZ (Transcriptional co-Activator with PDZ-binding motif), is a biologically potent transcriptional coactivator and functions by binding to the PPXY motif present in several transcription factors. Notably, TAZ behaves as a transducer linking cytoplasmic signaling events to transcriptional regulation in the ... | ['Active Transport, Cell Nucleus', 'Amino Acid Motifs', 'Carrier Proteins', 'Cell Line, Tumor', 'Cell Nucleus', 'Cytoplasm', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Lung', 'Nuclear Proteins', 'Protein Interaction Domains and Motifs', 'Pulmonary Surfactant-Associated Protein C', 'Thyroid Nuclear Fact... | 23,911,299 | [['G03.143.310.100', 'G03.143.700.100'], ['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['D12.776.157'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ['A0... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adolescent occupational injuries and workplace risks: an analysis of Oregon workers' compensation data 1990-1997. | PURPOSE: Injuries to adolescents from occupational activities has been recognized as a significant public health concern. The objective of this study was to quantify adolescent injury rates, analyze risk factors, and measure the severity of injuries sustained using Oregon workers' compensation data.METHODS: From 1990-1... | ['Accidents, Occupational', 'Adolescent', 'Adolescent Development', 'Adult', 'Age Factors', 'Circadian Rhythm', 'Employment', 'Female', 'Humans', 'Insurance Claim Review', 'Male', 'Occupations', 'Oregon', 'Risk Factors', 'Sex Factors', 'Work Schedule Tolerance', "Workers' Compensation", 'Wounds and Injuries'] | 17,707,294 | [['N06.850.135.240'], ['M01.060.057'], ['F01.525.049', 'G07.345.374.500'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['G07.180.562.190'], ['N01.824.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.215'], ['N01.824.547'], ['Z01.107.567.875.560.550', 'Z01.107.567.875.580.550'], ['E... | ['Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Distribution and health risk assessment to heavy metals near smelting and mining areas of Hezhang, China. | Mining and smelting areas in Hezhang have generated a large amount of heavy metals into the environment. For that cause, an evaluative study on human exposure to heavy metals including Co, Ni, Cu, Zn, Cr, As, Cd, Pb, Sb, Bi, Be, and Hg in hair and urine was conducted for their concentrations and correlations. Daily exp... | ['Agriculture', 'China', 'Environmental Exposure', 'Environmental Monitoring', 'Female', 'Food Contamination', 'Hair', 'Humans', 'Male', 'Mercury', 'Metals, Heavy', 'Mining', 'Risk Assessment', 'Soil', 'Soil Pollutants', 'Vegetables'] | 28,823,066 | [['J01.040'], ['Z01.252.474.164'], ['N06.850.460.350'], ['N06.850.460.350.080', 'N06.850.780.375'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['A17.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['D01.268.556', 'D01.552... | ['Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Gradual delay in glucose-induced first phase insulin secretion by the pancreatic islets of 7 week-, 6 month-, and 1 year-old rats. | The temporal profiles of insulin secretion by isolated pancreatic islets of male Wistar rats with various ages up to 1-year-old were studied using high glucose, potassium (K+) depolarization, and arginine as secretagogues. In the islets of 6-month-old rats, the onset and peak of glucose-induced first phase of insulin r... | ['Aging', 'Animals', 'Arginine', 'Calcium', 'Culture Techniques', 'Cytosol', 'Dose-Response Relationship, Drug', 'Glucose', 'Insulin', 'Insulin Secretion', 'Islets of Langerhans', 'Male', 'Potassium', 'Rats', 'Rats, Inbred Strains', 'Time Factors'] | 1,997,565 | [['G07.345.124'], ['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E05.481.500'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['G07.690.773.875', 'G07.690.936.500'], ['D09.947.875.359.448'], ['D06.472.699.587.200.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gene deletion explains both in vivo and in vitro generated chromosome 2 aberrations associated with murine myeloid leukemia. | Ninety-five percent of radiation-induced murine myeloid leukemias contain chromosome 2 aberrations. A dominant molecular defect has not yet been identified: both deletions and breakpoint-specific events have been postulated. We have generated a model in which chromosome 2 lesions have been generated in vitro in a clona... | ['Animals', 'Base Sequence', 'Chromosome Aberrations', 'Gene Deletion', 'Humans', 'Karyotyping', 'Leukemia, Myeloid', 'Mice', 'Molecular Sequence Data', 'Spleen', 'Tumor Cells, Cultured'] | 8,609,710 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C23.550.210', 'G05.365.590.175'], ['G05.365.590.762.320', 'G05.558.800.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315', 'E05.393.285.475'], ['C04.557.337.539'], ['B01.0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Acute pancreatitis in marrow transplant patients: prevalence at autopsy and risk factor analysis. | Pancreatitis has been described as an infrequent complication of marrow transplantation. This study investigated the prevalence of pancreatitis at autopsy in marrow transplant patients and determined risk factors for its development. We reviewed consecutive autopsy reports from 1991 to 1993. Medical records and laborat... | ['Abdominal Pain', 'Acute Disease', 'Adult', 'Amylases', 'Bile', 'Biomarkers', 'Bone Marrow Transplantation', 'Cause of Death', 'Cohort Studies', 'Cyclosporine', 'Drug Therapy, Combination', 'Female', 'Gallbladder', 'Graft vs Host Disease', 'Humans', 'Immunosuppressive Agents', 'Male', 'Methotrexate', 'Neoplasms', 'Pan... | 9,466,282 | [['C23.888.592.612.054', 'C23.888.821.030'], ['C23.550.291.125'], ['M01.060.116'], ['D08.811.277.450.066'], ['A12.200.087'], ['D23.101'], ['E02.095.147.725.040', 'E04.936.580.040'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['E05.318.372.500.750', ... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Alcohol and fatal injuries: temporal patterns. | Although alcohol use has been established as a risk factor for injuries associated with motor vehicle crashes, the role of alcohol for other unintentional and intentional injuries is less defined. A review of 102,401 deaths investigated by North Carolina medical examiners in the period 1973-1983 characterized the tempo... | ['Accidents', 'Adolescent', 'Adult', 'Alcohol Drinking', 'Cause of Death', 'Ethanol', 'Female', 'Homicide', 'Humans', 'Male', 'Middle Aged', 'North Carolina', 'Suicide', 'Time Factors', 'Wounds and Injuries'] | 2,789,850 | [['N06.850.135'], ['M01.060.057'], ['M01.060.116'], ['F01.145.317.269'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['D02.033.375'], ['I01.198.240.470', 'I01.880.735.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.... | ['Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Treatment of acute myocardial infarction in Switzerland: is emergency PTCA more costly than thrombolysis?]. | Confirming earlier studies with a lower number of patients, the Gusto IIb Angioplasty Substudy has shown that in the treatment of acute myocardial infarction emergency PTCA is superior to thrombolysis in reducing the combined clinical endpoints of death, reinfarction and cerebrovascular infarction. The aim of this stud... | ['Angioplasty, Balloon, Coronary', 'Costs and Cost Analysis', 'Fibrinolytic Agents', 'Follow-Up Studies', 'Hospitalization', 'Humans', 'Myocardial Infarction', 'Recombinant Proteins', 'Switzerland', 'Thrombolytic Therapy', 'Tissue Plasminogen Activator'] | 10,542,996 | [['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['N03.219.151'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['E05.318.372.500.750.249', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice. | We have shown that ornithine decarboxylase (ODC) overexpression in the skin of TG.AC v-Ha-ras transgenic mice induces the formation of spontaneous skin carcinomas. Treatment of ODC/Ras double transgenic mice with alpha-difluoromethylornithine (DFMO), a specific inhibitor of ODC enzyme activity, causes a rapid regressio... | ['Animals', 'Antineoplastic Agents', 'Cell Differentiation', 'Cell Division', 'Crosses, Genetic', 'Eflornithine', 'Enzyme Inhibitors', 'Female', 'Gene Expression', 'Genes, ras', 'In Situ Hybridization', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Neovascularization, Pathologic', 'Ornithine Decarboxylase'... | 11,059,762 | [['B01.050'], ['D27.505.954.248'], ['G04.152'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E05.393.281'], ['D12.125.068.665.340', 'D12.125.095.765.340'], ['D27.505.519.389'], ['G05.297'], ['G05.360.340.024.340.375.500.791.550'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Shigellosis due to occupational contact with non-human primates. | A small cluster of dysenteric illness, due to Shigella flexneri, was identified among technical assistants of a primate research unit. All of the affected individuals had been in regular contact with a colony of cynomolgus macaque monkeys, one of which was known to have suffered from acute haemorrhagic colitis in the p... | ['Animals', 'Dysentery, Bacillary', 'Feces', 'Humans', 'Macaca fascicularis', 'Monkey Diseases', 'Occupational Diseases', 'Shigella flexneri', 'United Kingdom', 'Zoonoses'] | 8,472,767 | [['B01.050'], ['C01.150.252.400.310.229', 'C06.405.205.331.479', 'C06.405.469.300.479'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['C22.735.500'], ['C24'], ['B03.440.450.425.850.450', 'B03.660.250.150.730.210'], ['Z01.542.363'], ['C01.973', '... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Molecular interaction of different chromium species with nucleotides and nucleic acids. | The interaction of chromium(III) and chromium(VI) with the phosphate groups of di- and triphosphate nucleotides were examined by 31P-NMR spectroscopy. Chemical shifts of the phosphate groups, indicating the formation of Cr-nucleotide complexes, could only be detected with Cr(III). When Cr(III) was generated from Cr(VI)... | ['Chromium', 'DNA', 'Magnetic Resonance Spectroscopy', 'Nucleotides', 'Phosphates', 'Poly A', 'Poly C', 'Poly G', 'Poly U'] | 2,702,714 | [['D01.268.556.175', 'D01.268.956.124', 'D01.552.544.175'], ['D13.444.308'], ['E05.196.867.519'], ['D09.408.620', 'D13.695'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650'], ['D13.695.578.550.500'], ['D13.695.578.550.560'], ['D13.695.578.550.600'], ['D13.695.578.550.750']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sequence comparison and predicted structure for the four exon-encoded regions of human insulin-like growth factor binding protein 4. | The IGFBPs bind to and modulate the function of the IGFs in various ways. Human IGFBP-4 inhibits IGF mediated cell proliferation. The IGFBP exon-encoded regions were aligned and secondary structure predictions for hIGFBP-4 were developed yielding predicted 3D co-ordinates for each such region of hIGFBP-4. The exon 1 en... | ['Amino Acid Sequence', 'Animals', 'Cattle', 'Consensus Sequence', 'Conserved Sequence', 'Databases, Factual', 'Exons', 'Humans', 'Insulin-Like Growth Factor Binding Protein 4', 'Models, Molecular', 'Molecular Sequence Data', 'Protein Structure, Secondary', 'Rats', 'Sequence Homology, Amino Acid'] | 8,930,016 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G02.111.570.580.175'], ['G02.111.570.580'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['G05.360.340.024.340.137.232'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.420.280'], ['E05.599.595'],... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Identification of Pancreatic Injury in Patients with Elevated Amylase or Lipase Level Using a Decision Tree Classifier: A Cross-Sectional Retrospective Analysis in a Level I Trauma Center. | BACKGROUND: In trauma patients, pancreatic injury is rare; however, if undiagnosed, it is associated with high morbidity and mortality rates. Few predictive models are available for the identification of pancreatic injury in trauma patients with elevated serum pancreatic enzymes. In this study, we aimed to construct a ... | ['Abdominal Injuries', 'Adolescent', 'Adult', 'Amylases', 'Biomarkers', 'Clinical Decision-Making', 'Cross-Sectional Studies', 'Decision Support Techniques', 'Decision Trees', 'Female', 'Humans', 'Lipase', 'Male', 'Middle Aged', 'Pancreas', 'Retrospective Studies', 'Sensitivity and Specificity', 'Trauma Centers', 'Youn... | 29,415,489 | [['C26.017'], ['M01.060.057'], ['M01.060.116'], ['D08.811.277.450.066'], ['D23.101'], ['E01.055'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.245', 'L01.313.500.750.190'], ['G17.162.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.352.100.400'], ['M01.060.1... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Alcohol consumption and impaired glycoregulation results in a population of 6665 salaried employees. | Alcohol consumption and glycosuria were found to be associated (p less than 0.001) in a population of 6571 salaried employees who underwent a systematic examination. The prevalence of glycosuria was found to range from 1.3% among 2609 non-drinkers to 5% among 816 heavy drinkers (six glasses or more of alcoholic beverag... | ['Adolescent', 'Adult', 'Age Factors', 'Alcohol Drinking', 'Blood Glucose', 'Body Constitution', 'Ethanol', 'Female', 'Glycosuria', 'Humans', 'Male', 'Middle Aged', 'Risk Factors', 'Sex Factors'] | 3,181,390 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.145.317.269'], ['D09.947.875.359.448.500'], ['E01.370.600.115', 'G07.100'], ['D02.033.375'], ['C12.777.934.363', 'C13.351.968.934.363', 'C18.452.394.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Heritability of insulin sensitivity in twins]. | OBJECTIVE: To explore the contribution of genetic and environmental effects to insulin sensitivity.METHODS: The insulin sensitivity of 249 pairs of twins was estimated by use of logarithm transformed homeostasis model assessment (HOMA), of whom 169 pairs were monozygous and 80 pairs dizygous. To formulate a univariate ... | ['Adult', 'Age Factors', 'Female', 'Humans', 'Insulin Resistance', 'Likelihood Functions', 'Male', 'Models, Genetic', 'Sex Factors', 'Twins'] | 14,710,250 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.830.500.475', 'N06.850.520.830.6... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ingestive behavior of pastured crossbred dairy cows offered different supplement types. | The aim of this study was to assess the effect of different supplements on the behavior variables of crossbred dairy cows that were in pasture that comprised two 4 ? 4 Latin squares (four periods, four treatments, and four animals). Each experimental period lasted 15 days (10 days to adapt animals to treatments and 5 d... | ['Animal Feed', 'Animals', 'Brazil', 'Breeding', 'Cattle', 'Dairying', 'Dietary Supplements', 'Digestion', 'Feeding Behavior', 'Female', 'Observation', 'Opuntia', 'Silage', 'Time Factors'] | 22,678,494 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['Z01.107.757.176'], ['E05.820.150', 'G05.090'], ['B01.050.150.900.649.313.500.380.271'], ['J01.040.246'], ['G07.203.300.456', 'J02.500.456'], ['G07.203.650.250', 'G10.261.190'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['E05.581.249'], ['B01.650.9... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
A correlative study between glucocorticoid receptor levels in human mononuclear leukocytes and biochemical data in Cushing's disease. | UNLABELLED: We determined glucocorticoid receptors in human mononuclear leukocytes in 9 patients with Cushing's disease, in order to correlate them with laboratory data. Receptors were measured by a whole-cell assay method, after incubation with [3H]-dexamethasone in the presence or absence of excess unlabelled hormone... | ['17-Ketosteroids', 'Adolescent', 'Adult', 'Calcium', 'Cushing Syndrome', 'Dexamethasone', 'Female', 'Humans', 'Hydrocortisone', 'Leukocytes, Mononuclear', 'Male', 'Middle Aged', 'Receptors, Glucocorticoid', 'Thyrotropin'] | 2,911,941 | [['D04.210.500.578.502', 'D06.472.040.502'], ['M01.060.057'], ['M01.060.116'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['C19.053.800.367'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', '... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Clinical relevance of survivin as a biomarker in neoplasms, especially in adult T-cell leukemias and acute leukemias. | Survivin has been identified as one of the top 4 transcripts among 3.5 million human transcriptomes uniformly up-regulated in cancer tissues but not in normal tissues. Therefore, we quantitatively determined the messenger RNA (mRNA) expression profile for survivin by a real-time reverse transcriptase-polymerase chain r... | ['Acute Disease', 'Adult', 'Biomarkers, Tumor', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Inhibitor of Apoptosis Proteins', 'Leukemia, Lymphocytic, Chronic, B-Cell', 'Leukemia, Lymphoid', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Leukemia, Myeloid', 'Leukemia-Lymphoma, Adult T-Cell', 'Microtubule-Assoc... | 15,293,568 | [['C23.550.291.125'], ['M01.060.116'], ['D23.101.140'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.464.938.750.210', 'D12.644.360.075.437', 'D12.776.476.075.437'], ['C04.557.337.428.080.1... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Application of SCAP to drug design. 1. Prediction of octanol-water partition coefficients using solvent-dependent conformational analyses. | The solvent-dependent conformational analysis procedure (SCAP) has been used to predict the octanol-water partition coefficients of 20 different compounds with an average absolute error of 9%. SCAP predicts partition coefficients almost as well as the Hansch procedure using pi constants where the absolute error for the... | ['Energy Transfer', 'Kinetics', 'Molecular Conformation', 'Octanols', 'Quantum Theory', 'Solvents', 'Structure-Activity Relationship', 'Water'] | 1,271,397 | [['G01.154.240', 'G02.111.255', 'G02.216'], ['G01.374.661', 'G02.111.490'], ['G02.111.570.820'], ['D02.033.415.600', 'D10.289.600'], ['H01.671.579.800'], ['D27.720.844'], ['G02.111.830', 'G07.690.773.997'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Survival in post-infarction heart rupture. A case report. Role of echocardiography in immediate diagnostic approach]. | A case of acute myocardial infarction of the inferior-posterior and lateral wall of the left ventricle, complicated at the onset with cardiogenic shock and myocardial rupture of the free wall, is presented. The precise and immediate echocardiographic diagnosis made it possible, by means of appropriate pharmacologic sup... | ['Echocardiography', 'Electrocardiography', 'Heart Rupture, Post-Infarction', 'Humans', 'Male', 'Middle Aged'] | 1,803,285 | [['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E01.370.370.380.240', 'E01.370.405.240'], ['C14.280.470.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Drug combinations in the therapy of low response to phosphodiesterase 5 inhibitors in patients with erectile dysfunction. | Combinatorial drugs utilising a clinically-proven single agent approach in erectile dysfunction (ED) have led to the search for additional compounds to improve therapy and the safety profile. Selective inhibitors of Phosphodiesterase type 5, such as Sildenafil, demonstrate a defined failure rate in ED. The therapeutic ... | ['Adult', 'Aged', 'Dihydroergotamine', 'Dopamine Agonists', 'Dose-Response Relationship, Drug', 'Drug Therapy, Combination', 'Erectile Dysfunction', 'Humans', 'Male', 'Middle Aged', 'Phosphodiesterase Inhibitors', 'Piperazines', 'Purines', 'Sildenafil Citrate', 'Sulfones'] | 12,494,876 | [['M01.060.116'], ['M01.060.116.100'], ['D03.132.327.412.225', 'D03.633.400.562.300'], ['D27.505.519.625.150.151', 'D27.505.696.577.150.151'], ['G07.690.773.875', 'G07.690.936.500'], ['E02.319.310'], ['C12.294.644.486', 'F03.835.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D27.505.519.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prestorage heat treatment to maintain nutritive and functional properties during postharvest cold storage of pomegranate. | Heat treatments have been used to extend storability of several fruits, although no information is available about their effects on nutritive and functional properties in pomegranates, which was the objective of this research. Thus, pomegranate fruits were heat treated (dips at 45 degrees C for 4 min) and stored at 2 d... | ['Anthocyanins', 'Antioxidants', 'Ascorbic Acid', 'Carbohydrate Metabolism', 'Carbohydrates', 'Cold Temperature', 'Food Preservation', 'Hot Temperature', 'Lythraceae'] | 17,061,826 | [['D03.383.663.283.266.450.087', 'D03.633.100.150.266.450.087', 'D09.408.084', 'D23.767.124'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['G02.111.158', 'G03.191'], ['D09'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.75... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Influences on food choice perceived to be important by nationally-representative samples of adults in the European Union. | OBJECTIVE: The purpose of this baseline survey was to obtain comparable data on perceived influences on food choice from EU member countries as the starting point for EU healthy eating promotion campaigns and programmes.DESIGN: A cross-sectional study in which quota-controlled, nationally-representative samples of appr... | ['Adolescent', 'Adult', 'Attitude to Health', 'Costs and Cost Analysis', 'Cross-Sectional Studies', 'Diet', 'Diet Surveys', 'Europe', 'Female', 'Food Preferences', 'Humans', 'Male', 'Middle Aged', 'Socioeconomic Factors', 'Surveys and Questionnaires', 'Taste'] | 9,222,718 | [['M01.060.057'], ['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['N03.219.151'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.203.650.240'], ['E05.318.308.980.485.350', 'N05.715.360.300.800.469.300', 'N06.850.505.616.300', 'N06.850.520.308.980.469.350'], ['Z01.542'], ['F01.145... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Coexistence of Graves' disease and unilateral functioning Struma ovarii: a case report. | BACKGROUND: Coexisting of Graves' disease and functioning struma ovarii is a rare condition. Although the histology of struma ovarii predominantly composed of thyrocytes, the majority of the patients did not have thyrotoxicosis. The mechanism underlying the functioning status of the tumor is still unclear but the prese... | ['Antithyroid Agents', 'Female', 'Graves Disease', 'Humans', 'Hysterectomy', 'Methimazole', 'Middle Aged', 'Ovarian Neoplasms', 'Ovariectomy', 'Salpingectomy', 'Struma Ovarii', 'Thyroidectomy', 'Thyrotoxicosis', 'Treatment Outcome'] | 26,530,865 | [['D06.347.100', 'D27.505.696.399.450.100'], ['C11.675.349.500', 'C19.874.283.605', 'C19.874.397.370', 'C20.111.555'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['D02.886.489.600', 'D03.383.129.308.535'], ['M01.060.116.630'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.68... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations. | Hox genes regulate axial regional specification during animal embryonic development and are grouped into four clusters. The mouse HoxB cluster contains 10 genes, Hoxb1 to Hoxb9 and Hoxb13, which are transcribed in the same direction. We have generated a mouse strain with a targeted 90-kb deletion within the HoxB cluste... | ['Animals', 'Cranial Nerves', 'Gene Deletion', 'Genes, Homeobox', 'Mice', 'Mice, Mutant Strains', 'Multigene Family', 'Phenotype'] | 10,885,747 | [['B01.050'], ['A08.800.800.120'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.360.340.024.340.230.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550'], ['G05.360.340.024.340.645'], ['G05.695']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High-Intensity Interval Training for Cognitive and Mental Health in Adolescents. | PURPOSE: Emerging literature suggests that physical activity and fitness may have a positive effect on cognitive and mental health in adolescents. The purpose of the current study was to evaluate the efficacy of two high-intensity interval training (HIIT) protocols for improving cognitive and mental health outcomes (ex... | ['Adolescent', 'Cognition', 'Emotions', 'Executive Function', 'Female', 'Heart Rate', 'High-Intensity Interval Training', 'Humans', 'Male', 'Mental Health', 'Psychology, Adolescent', 'Self Concept', 'Stress, Psychological'] | 27,187,097 | [['M01.060.057'], ['F02.463.188'], ['F01.470'], ['F02.463.217'], ['E01.370.600.875.500', 'G09.330.380.500'], ['G11.427.410.698.277.311.250', 'I03.350.311.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.418', 'N01.400.500'], ['F04.096.628.065'], ['F01.752.747.792'], ['F01.145.126.990', 'F02.830.900']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase C á signaling in THP-1 macrophage-derived foam cells. | Apelin has an antiatherogenic function through activating protein kinase C (PKC) to initiate a series of cellular signaling pathways. PKC phosphorylates and stabilizes ATP-binding cassette transporter A1 (ABCA1) through inhibiting its degradation mediated by calpain. Thus, in the present study, we investigated whether ... | ['ATP Binding Cassette Transporter 1', 'ATP-Binding Cassette Transporters', 'Calpain', 'Cell Line', 'Cholesterol', 'Foam Cells', 'Humans', 'Intercellular Signaling Peptides and Proteins', 'Macrophages', 'Protein Kinase C-alpha'] | 23,290,264 | [['D12.776.157.530.100.050.500', 'D12.776.395.550.020.381.500', 'D12.776.543.550.192.381.500', 'D12.776.543.585.100.190.500'], ['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['D08.811.277.656.262.500.120', 'D08.811.277.656.300.200.120'], ['A11.251.210'], ['D04.210.500.247.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Muir-Torre syndrome: clinical features and molecular genetic analysis. | We report a 62-year-old man with rectal cancer, two keratoacanthomas and multiple sebaceous adenomas, epitheliomas and sebaceous hyperplasia. His brother and father died from colorectal cancer. A subgroup of patients with the Muir-Torre syndrome (MTS) is allelic to the cancer family syndrome. This genetic disorder is c... | ['Carcinoma', 'Facial Neoplasms', 'Frameshift Mutation', 'Humans', 'Hyperplasia', 'Keratoacanthoma', 'Male', 'Middle Aged', 'Neoplasms, Multiple Primary', 'Rectal Neoplasms', 'Sebaceous Gland Neoplasms', 'Skin', 'Skin Diseases', 'Syndrome'] | 9,217,825 | [['C04.557.470.200'], ['C04.588.443.392'], ['G05.365.590.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.444'], ['C17.800.417'], ['M01.060.116.630'], ['C04.651'], ['C04.588.274.476.411.307.790', 'C06.301.371.411.307.790', 'C06.405.249.411.307.790', 'C06.405.469.491.307.790', 'C06.405.469.860.180.500']... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Absolute ionization dosimetry of high energy electrons with an energy of more than 15 Mev]. | By means of a graphite double extrapolation chamber, the self consistent dosimetry system already used for an electron energy until 15 MeV also allows an absolute determination of the cavity ion dose until 42 MeV which can be performed under practically ideal Bragg-Gray conditions with the precision of a primary standa... | ['Electrons', 'Ions', 'Mathematics', 'Radiation Dosage'] | 6,612,763 | [['G01.249.335', 'G01.358.500.750'], ['D01.248.497'], ['H01.548'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Vitreous glucose in bacterial and sterile endophthalmitis. | Bacterial or sterile endophthalmitis was induced in rabbits. The vitreous glucose levels were then assayed. Severe intraocular inflammation, whether bacterial or sterile, resulted in marked lowering of vitreous glucose as compared to control levels. Moderate or mild inflammation failed to reduce the vitreous glucose. T... | ['Animals', 'Bacterial Infections', 'Blood Glucose', 'Endophthalmitis', 'Glucose', 'Rabbits', 'Retina', 'Serum Albumin', 'Staphylococcal Infections', 'Vitreous Body'] | 3,489,693 | [['B01.050'], ['C01.150.252'], ['D09.947.875.359.448.500'], ['C01.375.265', 'C11.294.265'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.968.700'], ['A09.371.729'], ['D12.776.034.841', 'D12.776.124.727'], ['C01.150.252.410.868'], ['A09.371.714.500']] | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Epidemiological and immunological characteristics of childhood leukaemia in The Netherlands: population-based data from a nationwide co-operative group of paediatricians. | In this review results are presented from several population-based epidemiological and immunological studies of children with leukaemia in The Netherlands, who were diagnosed between 1973 and 1982 through a nationwide co-operative group of paediatricians. From 1973 till 1980 annual incidence rates appeared to be 3.1 pe... | ['Acute Disease', 'Adolescent', 'Age Factors', 'B-Lymphocytes', 'Child', 'Child, Preschool', 'Data Collection', 'Female', 'Humans', 'Infant', 'Leukemia', 'Leukemia, Lymphoid', 'Leukemia, Myeloid', 'Male', 'Netherlands', 'Phenotype', 'Sex Factors', 'T-Lymphocytes'] | 3,874,331 | [['C23.550.291.125'], ['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['B01.050.15... | ['Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Sacral nerve stimulation for refractory urge symptoms in elderly patients. | OBJECTIVE: The presence of an overactive detrusor (OD) is becoming more prevalent in the elderly and may severely influence the social life and activities of daily living in the senior, otherwise healthy, person. There is a marked age-dependent increase in OD above the age of 65 years, which is mainly attributed to dys... | ['Aged', 'Electric Stimulation Therapy', 'Female', 'Humans', 'Lumbosacral Plexus', 'Male', 'Multicenter Studies as Topic', 'Prospective Studies', 'Quality of Life', 'Randomized Controlled Trials as Topic', 'Treatment Outcome', 'Urinary Bladder, Neurogenic', 'Urinary Incontinence'] | 15,204,397 | [['M01.060.116.100'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.800.800.720.450'], ['E05.318.372.658', 'N05.715.360.330.643', 'N06.850.520.450.643'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['I01.800', 'K01.75... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
A theoretical study of the contrast recovery and variance of MAP reconstructions from PET data. | We examine the spatial resolution and variance properties of PET images reconstructed using maximum a posteriori (MAP) or penalized-likelihood methods. Resolution is characterized by the contrast recovery coefficient (CRC) of the local impulse response. Simplified approximate expressions are derived for the local impul... | ['Analysis of Variance', 'Animals', 'Models, Theoretical', 'Normal Distribution', 'Tomography, Emission-Computed'] | 10,385,287 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['E05.599'], ['E05.318.740.994.500', 'G17.820.500', 'N05.715.360.750.750.565', 'N06.850.520.830.994.500'], ['E01.370.350.350.800', 'E01.370.350.600.350.800', 'E01.370.350.710.800', 'E01.370.350.825.800', 'E01.370.384.730.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The effect of a magnesium deficient diet and cortisone on the growth of the rat incisor. | Incisors of Mg-deficient rats showed a marked inhibition of eruption and a decrease in mitoses of apical tissues. Cortisone administration resulted in some increase in eruption rate and cell division though these remained below the values of Mg-supplemented controls. An improvement in gross condition and a less severe ... | ['Animals', 'Cell Division', 'Cortisone', 'Dental Enamel', 'Dentin', 'Diet', 'Female', 'Incisor', 'Magnesium Deficiency', 'Mice', 'Mitosis', 'Odontogenesis', 'Tooth Eruption'] | 277,480 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D04.210.500.745.745.183', 'D06.472.040.585.478.195'], ['A14.549.167.900.255'], ['A14.549.167.900.280'], ['G07.203.650.240'], ['A14.549.167.860.425'], ['C18.654.521.500.439'], ['B01.050.150.900.649.313.992.635.505.500'], ['G04.144.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
How can additional secondary data analysis of observational data enhance the generalisability of meta-analytic evidence for local public health decision making? | This paper critically explores how survey and routinely collected data could aid in assessing the generalisability of public health evidence. We propose developing approaches that could be employed in understanding the relevance of public health evidence, and investigate ways of producing meta-analytic estimates tailor... | ['Calibration', 'Data Analysis', 'Data Interpretation, Statistical', 'Decision Making', 'England', 'Evidence-Based Medicine', 'Humans', 'Meta-Analysis as Topic', 'Observational Studies as Topic', 'Public Health', 'Statistics as Topic', 'United Kingdom', 'Wales'] | 30,129,995 | [['E05.978.155'], ['H01.548.338'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['F02.463.785.373'], ['Z01.542.363.300'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.500', 'E05.581.500.501', 'N05.715.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Phosphorylation of histone H3 is functionally linked to retinoic acid receptor beta promoter activation. | Ligand-dependent transcriptional activation of retinoic acid receptors (RARs) is a multistep process culminating in the formation of a multimeric co-activator complex on regulated promoters. Several co-activator complexes harbor an acetyl transferase activity, which is required for retinoid-induced transcription of rep... | ['Animals', 'Histones', 'Mice', 'Phosphorylation', 'Precipitin Tests', 'Promoter Regions, Genetic', 'Protamine Kinase', 'Protein Processing, Post-Translational', 'Receptors, Retinoic Acid', 'Tretinoin'] | 11,897,660 | [['B01.050'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['B01.050.150.900.649.313.992.635.505.500'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['E01.370.225.812.735.645', 'E05.196.150.639.500', 'E05.200.812.735.645', 'E05.478.594.760.645', 'E05.478.605.492'], ['G02.111.570.080.689.675', 'G05.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Social regulation of ageing by young workers in the honey bee, Apis mellifera. | Organisms' lifespans are modulated by both genetic and environmental factors. The lifespan of eusocial insects is determined by features of the division of labor, which itself is influenced by social regulatory mechanisms. In the honey bee, Apis mellifera, the presence of brood and of old workers carrying out foraging ... | ['Aging', 'Animals', 'Bees', 'Gene Expression', 'Glycoproteins', 'Insect Proteins', 'Social Behavior', 'Vitellogenins'] | 27,865,886 | [['G07.345.124'], ['B01.050'], ['B01.050.500.131.617.720.500.500.875.387'], ['G05.297'], ['D09.400.430', 'D12.776.395'], ['D12.776.093.500'], ['F01.145.813'], ['D12.776.093.500.925', 'D12.776.290.812.500', 'D12.776.744.925']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bacteriology of the maxillary and ethmoid sinuses in chronic sinusitis. | The bacteriology of chronic sinusitis was studied by using swab and mucosal specimens from both the maxillary and ethmoid sinuses. The specimens of the maxillary sinus were taken through translabial antroscopy. The specimens of the ethmoid sinus were taken after removing the ethmoid bulla during functional endoscopic s... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Chronic Disease', 'Citrobacter', 'Ethmoid Sinus', 'Ethmoid Sinusitis', 'Female', 'Haemophilus influenzae', 'Humans', 'Male', 'Maxillary Sinus', 'Maxillary Sinusitis', 'Middle Aged', 'Mucous Membrane', 'Sinusitis', 'Specimen Handling', 'Staphylococcus epidermidis', 'Streptococcu... | 9,876,374 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['C23.550.291.500'], ['B03.440.450.425.200', 'B03.660.250.150.100'], ['A04.531.621.267'], ['C01.748.749.267', 'C08.460.692.752.267', 'C08.730.749.267', 'C09.603.692.752.267'], ['B03.440.450.600.450.330', 'B03.660.250.550.290.330'], ['B01.050.150.9... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An analysis of corneal transplantation: II--postoperative astigmatism. | An analysis of 153 penetrating keratoplasties was undertaken. The same surgical technique was used in all cases. Three factors had a statistically significant effect on postoperative astigmatism, as measured by keratometry. (1) Astigmatism decreased with increasing follow-up time (P less than 0.05). (2) Vitreous loss a... | ['Astigmatism', 'Corneal Transplantation', 'Female', 'Follow-Up Studies', 'Humans', 'Keratitis, Dendritic', 'Male', 'Postoperative Complications', 'Sex Factors', 'Transplantation, Homologous', 'Vitreous Body'] | 378,088 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of phosphate upon calcium intestinal absorption (author's transl)]. | Adult rats receive 5 to 50 mM CaCl2 solutions in which glycerophosphate or sodium diacid phosphate may be added in variable quantity. These solutions are administered by gavage or in situ ligatured jejunal loop. The inhibition of calcium absorption dependent on simultaneously administered phosphate doses is well charac... | ['Alkaline Phosphatase', 'Animals', 'Biological Transport', 'Calcium', 'Depression, Chemical', 'Intestinal Absorption', 'Phosphates', 'Rats', 'Solubility'] | 796,796 | [['D08.811.277.352.650.035'], ['B01.050'], ['G03.143'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G07.690.773.750'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', 'G10.261.353.500'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anti-inflammatory effect of the compounds from the flowers of Trollius chinensis. | In order to investigate the anti-inflammatory activity of flavonoids, phenolic acids, and alkaloids from the flowers of Trollius chinensis, some representative compounds, namely, orientin, 2"-O-â-L-galactopyranosylorientin, vitexin, quercetin, isoquercetin, luteolin, veratric acid, proglobeflowery acid, trollioside, an... | ['Alkaloids', 'Animals', 'Anti-Inflammatory Agents', 'Apigenin', 'Cell Survival', 'Dose-Response Relationship, Drug', 'Flavonoids', 'Flowers', 'Glucosides', 'Mice', 'Plant Extracts', 'RAW 264.7 Cells', 'Ranunculaceae', 'Vanillic Acid'] | 30,150,194 | [['D03.132'], ['B01.050'], ['D27.505.954.158'], ['D03.383.663.283.266.450.260.110', 'D03.633.100.150.266.450.260.110'], ['G04.346'], ['G07.690.773.875', 'G07.690.936.500'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['A18.024.249.500'], ['D09.408.348'], ['B01.050.150.900.649.313.992.635.505.500'], ['D20.21... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Histological and ultrastructural studies of rats exposed to carbaryl. | The aim of the study was to assess the general toxic effects of dermally applied carbaryl, based on histological and ultrastructural examinations of internal organs and to relate these effects to earlier own studies where 14C carbaryl was used for determining the pesticide penetration. The pesticide was applied in dose... | ['Administration, Cutaneous', 'Animals', 'Carbaryl', 'Carbon Isotopes', 'Environmental Exposure', 'Insecticides', 'Kidney', 'Lethal Dose 50', 'Liver', 'Lung', 'Male', 'Myocardium', 'Rats', 'Rats, Wistar', 'Skin', 'Skin Absorption'] | 11,748,870 | [['E02.319.267.120.060'], ['B01.050'], ['D02.241.081.251.150', 'D02.455.426.559.847.638.162', 'D04.615.638.162'], ['D01.268.150.075', 'D01.496.123'], ['N06.850.460.350'], ['D27.720.031.700.491', 'D27.888.723.491'], ['A05.810.453'], ['E05.940.402', 'G07.225.500', 'G07.690.773.875.750', 'G07.690.936.500.750'], ['A03.620'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Chronic Pulmonary Artery Embolization Models in Large Animals. | A wide range of approaches have been described to develop animal models of pulmonary vascular disease (PVD). Clinical heterogeneity in patients with pulmonary hypertension (PH) has prompted development of different techniques to create PH models in several animal species with the objective to recapitulate specific PH/P... | ['Animals', 'Disease Models, Animal', 'Echocardiography', 'Hemodynamics', 'Hypertension, Pulmonary', 'Pulmonary Embolism', 'Swine', 'Vascular Remodeling'] | 29,987,834 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['G09.330.380'], ['C08.381.423', 'C14.907.489.556'], ['C08.381.746', 'C14.907.355.350.700'], ['B01.050.150.900.649.313.500.880'], ['C23.300.977', 'C23.550.918', 'G09.330.930']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
New bis-catechols 5-lipoxygenase inhibitors. | Three polyhydroxy-2-phenylnaphthalenes (1-3) and the oxy analogue of tetrahydroxypavinan (4) were prepared and evaluated for their antioxidant properties (inhibition of diphenylpycrylhydrazyl radical (DPPH), reduction of iron (III) ion) and inhibition of 5-lipoxygenase (5-LO) activity. Their three-dimensional structure... | ['Animals', 'Antioxidants', 'Arachidonate 5-Lipoxygenase', 'Bepridil', 'Biphenyl Compounds', 'Catechols', 'Indicators and Reagents', 'Iron', 'Kinetics', 'Lipoxygenase Inhibitors', 'Molecular Structure', 'Oxidation-Reduction', 'Picrates', 'Rats', 'Structure-Activity Relationship', 'Tumor Cells, Cultured'] | 11,249,115 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D08.811.682.690.416.583.500.055', 'D12.776.556.579.374.568.500.020'], ['D03.383.773.107'], ['D02.455.426.559.389.185'], ['D02.455.426.559.389.657.166'], ['D27.720.470.410'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['G01.37... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Breastfeeding and vitamin D status in Greece during the first 6 months of life. | UNLABELLED: Since no foods are vitamin D supplemented in Greece, vitamin D status was assessed in mothers at birth and their infants up to the first 6 months of life, while they were exclusively breast-fed. This was a prospective study. Full-terms (n =35) born during the summer-autumn months and their mothers were assi... | ['Adult', 'Breast Feeding', 'Female', 'Greece', 'Humans', 'Infant', 'Infant, Newborn', 'Prospective Studies', 'Reference Values', 'Seasons', 'Vitamin D', 'Vitamin D Deficiency'] | 16,143,866 | [['M01.060.116'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['Z01.542.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.978.810'], ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Comparison of Doppler ultrasonography and high-definition oscillometry for blood pressure measurements in healthy awake dogs. | OBJECTIVE: To determine the intra- and interobserver variability of systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) measurements obtained with 2 indirect methods in awake dogs and percentage of successful measurements.ANIMALS: 6 healthy conscious adult dogs.PROCEDURES: 4 observers with different ... | ['Animals', 'Blood Pressure', 'Blood Pressure Determination', 'Consciousness', 'Dogs', 'Female', 'Humans', 'Observer Variation', 'Oscillometry', 'Reference Values', 'Sensitivity and Specificity', 'Ultrasonography, Doppler'] | 20,594,078 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140', 'E01.370.600.100'], ['F02.463.188.409', 'F02.830.233'], ['B01.050.150.900.649.313.750.250.216.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E05.654'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Final results of randomized trials by the National Surgical Adjuvant Study of Colorectal Cancer (NSAS-CC). | OBJECTIVE: In the latter 1990s, adjuvant chemotherapy for completely resected Stage III colorectal cancer remained controversial in Japan. We conducted two independent randomized controlled trials in patients with Stage III colon and rectal cancer.METHODS: Patients were randomly assigned to receive surgery alone or sur... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Chemotherapy, Adjuvant', 'Colonic Neoplasms', 'Combined Modality Therapy', 'Disease-Free Survival', 'Female', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Rectal Neoplasms', 'Survival Rate', 'Treatment Outcome'] | 20,490,797 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E02.186.170', 'E02.319.170'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['E02.186'], ['E01.789.800.190', 'E05.318.740.998... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Breakfast Consumption, Family Breakfast, and Adiposity Trajectory in Adolescence-The Adolescent Nutritional Assessment Longitudinal Cohort Study. | BACKGROUND: The relationship between breakfast and family breakfast and adiposity gain during adolescence remains inconclusive.OBJECTIVE: This study aimed to investigate the relationship between breakfast and family breakfast frequency and adiposity trajectory in adolescence.DESIGN: Prospective cohort study with middle... | ['Adiposity', 'Adolescent', 'Body Mass Index', 'Breakfast', 'Child', 'Family', 'Feeding Behavior', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Nutrition Assessment', 'Pediatric Obesity', 'Prospective Studies'] | 30,745,069 | [['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.057'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['G07.203.300.590.120', 'J02.500.590.120'], ['M01.060.406'], ['F01.829.263', 'I01.880.853.150'], ['F01.145.113... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Oral bisphosphonate use and risk of postmenopausal endometrial cancer. | PURPOSE: Bisphosphonates are common medications used for the treatment of osteoporosis and are also used to reduce metastases to bone in patients with cancer. Several studies, including the Women's Health Initiative (WHI), have found that use of bisphosphonates is associated with reduced risk of developing breast cance... | ['Administration, Oral', 'Aged', 'Bone Density Conservation Agents', 'Diphosphonates', 'Endometrial Neoplasms', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Middle Aged', 'Postmenopause', 'Prospective Studies', 'Risk Assessment', 'Risk Factors', 'Time Factors', 'United States'] | 25,713,431 | [['E02.319.267.100'], ['M01.060.116.100'], ['D27.505.696.242'], ['D02.705.429.500'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.30... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Clinical and Economic Impact of Time From Admission for CSF Rhinorrhea to Surgical Repair. | BACKGROUND: If conservative management of CSF leak is unsuccessful, surgical repair is indicated for the prevention of severe complications such as meningitis. This study investigated the influence of surgical timing on clinical and economic outcomes.METHODS: Retrospective review of the National Inpatient Sample (2012)... | ['Adult', 'Aged', 'Cerebrospinal Fluid Rhinorrhea', 'Female', 'Humans', 'Male', 'Middle Aged', 'Patient Admission', 'Retrospective Studies', 'Time-to-Treatment', 'Treatment Outcome'] | 30,194,732 | [['M01.060.116'], ['M01.060.116.100'], ['C10.597.114.750', 'C10.900.300.109.750', 'C23.888.592.114.624', 'C23.888.852.834.500', 'C26.915.300.225.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.760.400.600', 'N02.421.585.400.600'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750',... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
H-2 antigenicity of Leydig cells. | Partial absorption of oligospecific reagents by the particulate membrane fraction prepared from isolated interstitial cells grown in culture (the harvested cell population contained about 80% Leydig cells)suggests that membranes of Leydig cells carry antigenic specificities H-2K (11,25) and H-2D (4) but not antigens co... | ['Animals', 'Cytotoxicity Tests, Immunologic', 'Female', 'Fluorescent Antibody Technique', 'H-2 Antigens', 'Immunosorbent Techniques', 'Leydig Cells', 'Male', 'Mice', 'Mice, Inbred Strains'] | 7,021,209 | [['B01.050'], ['E01.370.225.812.160', 'E05.200.812.160', 'E05.478.594.160', 'E05.940.245'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['D23.050.301.500.100.350', 'D23.050.301.500.400.199', 'D23.050.705.552.100.350', 'D23.050.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical relevance of homocysteine levels in patients receiving coronary stenting for unstable angina. | BACKGROUND: We prospectively investigated whether plasma homocysteine (HCY) concentrations are related to target lesion revascularization (TLR) rates in patients with unstable angina undergoing stenting.METHODS: We enrolled 196 consecutive patients with at least one successful coronary stent implantation for unstable a... | ['Aged', 'Aged, 80 and over', 'Angina, Unstable', 'Angioplasty, Balloon, Coronary', 'Biomarkers', 'Blood Vessel Prosthesis Implantation', 'C-Reactive Protein', 'Coronary Angiography', 'Coronary Artery Bypass', 'Coronary Stenosis', 'Female', 'Follow-Up Studies', 'Homocysteine', 'Humans', 'Italy', 'Male', 'Middle Aged', ... | 15,119,501 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.647.187.150', 'C14.907.585.187.150', 'C23.888.592.612.233.500.150'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Arterial vasodilating profile and biological effects of pinacidil in healthy volunteers. | 1. The effects of pinacidil (25 mg, sustained release formulation) a) on systemic (arterial pressure, cardiac output) and regional (brachial and carotid arteries' diameters and flows) haemodynamics (pulsed Doppler techniques), b) on sympathetic (plasma noradrenaline) and renin-angiotensin (plasma renin activity) system... | ['Adult', 'Arteries', 'Guanidines', 'Hemodynamics', 'Hormones', 'Humans', 'Pinacidil', 'Regional Blood Flow', 'Renin-Angiotensin System', 'Sympathetic Nervous System', 'Vasodilation'] | 2,015,168 | [['M01.060.116'], ['A07.015.114'], ['D02.078.370'], ['G09.330.380'], ['D06.472', 'D27.505.696.399.472'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.078.370.729'], ['G09.330.100.780'], ['G03.820', 'G09.330.380.813'], ['A08.800.050.800'], ['G09.330.380.928']] | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Radiation sensitivity of megakaryocyte colony-forming cells in human placental and umbilical cord blood. | The in vitro radiation sensitivity of CFU-Meg isolated from human placental and umbilical cord blood was evaluated in plasma clot cultures stimulated by recombinant human cytokines, including thrombopoietin, the FLT3 ligand (FLT3LG), interleukin-3, interleukin-11 and stem cell factor. The CD34(+) cells were irradiated ... | ['Antigens, CD34', 'Cell Division', 'Cell Survival', 'Cytokines', 'Fetal Blood', 'Humans', 'Megakaryocytes', 'Placenta', 'Radiation Tolerance', 'Recombinant Proteins', 'Thrombopoietin'] | 10,629,613 | [['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.346'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.148.479', 'A15.378.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The matrix protein gene determines amantadine-sensitivity of influenza viruses. | The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, tha... | ['Amantadine', 'Drug Resistance, Microbial', 'Genes, Viral', 'Influenza A virus', 'Recombination, Genetic', 'Viral Proteins'] | 759,556 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Patterns of population subdivision, gene flow and genetic variability in the African wild dog (Lycaon pictus). | African wild dogs are large, highly mobile carnivores that are known to disperse over considerable distances and are rare throughout much of their geographical range. Consequently, genetic variation within and differentiation between geographically separated populations is predicted to be minimal. We determined the gen... | ['Africa', 'Animals', 'Animals, Wild', 'Carnivora', 'DNA, Mitochondrial', 'Ecology', 'Female', 'Gene Frequency', 'Genetic Variation', 'Genetics, Population', 'Locus Control Region', 'Male', 'Microsatellite Repeats', 'Phylogeny'] | 11,472,538 | [['Z01.058'], ['B01.050'], ['B01.050.050.300'], ['B01.050.150.900.649.313.750'], ['D13.444.308.283.225'], ['H01.158.273.248', 'H01.277.249'], ['G05.330'], ['G05.365'], ['H01.158.273.343.335'], ['G02.111.570.080.689.450', 'G05.360.080.689.450', 'G05.360.340.024.380.249'], ['G02.111.570.080.708.800.500', 'G05.360.080.708... | ['Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
Alterations in average spectrum of cochleoneural activity by long-term salicylate treatment in the guinea pig: a plausible index of tinnitus. | Salicylate, one of the most widely used drugs, produces at repetitive high doses reversible tinnitus and hearing loss. Neural correlates of hearing loss have long been established, whereas they remain elusive for tinnitus. The average spectrum of electrophysiological cochleoneural activity (ASECA), a measure of spontan... | ['Acoustic Stimulation', 'Action Potentials', 'Animals', 'Cochlear Nerve', 'Electrophysiology', 'Guinea Pigs', 'Lidocaine', 'Salicylates', 'Time Factors', 'Tinnitus'] | 9,772,265 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['A08.800.800.120.910.120'], ['H01.158.344.528', 'H01.158.782.236'], ['B01.050.150.900.649.313.992.550'], ['D02.065.199.092.500', 'D02.092.146.113.092.500'], ['D02.241.223.100.300.595', 'D02.241.511.390.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of the cytoplasmic tail domains of Bunyamwera orthobunyavirus glycoproteins Gn and Gc in virus assembly and morphogenesis. | The M RNA genome segment of Bunyamwera virus (BUNV), the prototype of the Bunyaviridae family, encodes a precursor polyprotein that is proteolytically cleaved to yield two structural proteins, Gn and Gc, and a nonstructural protein called NSm. Gn and Gc are type I integral transmembrane glycoproteins. The Gn protein co... | ['Amino Acid Substitution', 'Animals', 'Bunyamwera virus', 'Chlorocebus aethiops', 'Cricetinae', 'Giant Cells', 'Glycoproteins', 'Humans', 'Hydrogen-Ion Concentration', 'Protein Precursors', 'Protein Structure, Tertiary', 'Vero Cells', 'Viral Structural Proteins', 'Virus Assembly'] | 17,609,275 | [['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['B04.820.480.750.640.147'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['B01.050.150.900.649.313.992.635.075.250'], ['A11.500'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['D12.776.811'], ['G02.111.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sensitive quantitation of carcinoembryonic antigen in cerebrospinal fluid and its barrier-dependent differentiation. | Modification of an enzyme immunoassay using beads as solid phase allows the detection of 3 pg/ml carcinoembryonic antigen (CEA). The beads are shown to be advantageous for the extraction of proteins in highly diluted antigen solutions thus replacing a need for concentration of the sample. The mean concentration of CEA ... | ['Blood-Brain Barrier', 'Brain Neoplasms', 'Carcinoembryonic Antigen', 'Humans', 'Immunoenzyme Techniques', 'Neoplasms', 'Reference Values'] | 3,521,950 | [['A07.035', 'A08.186.211.035'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'],... | ['Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stimulatory lipids accumulate in the mouse liver within 30 min of contact sensitization to facilitate the activation of Na?ve iNKT cells in a CD1d-dependent fashion. | Natural killer T cells with invariant áâ-T cell receptors (TCRs) (iNKT cells) constitute a lipid-responsive arm of the innate immune system that has been implicated in the regulation or promotion of various immune, infectious and neoplastic processes. Contact sensitivity (CS), also known as contact hypersensitivity or ... | ['Adoptive Transfer', 'Animals', 'Antigens, CD1d', 'Dermatitis, Contact', 'Hepatocytes', 'Lipids', 'Liver', 'Lymphocyte Activation', 'Mice', 'Mice, Knockout', 'Natural Killer T-Cells'] | 21,352,253 | [['E02.095.465.425.400.330.050', 'E05.478.550.520.050'], ['B01.050'], ['D23.050.301.264.035.100.500', 'D23.050.301.264.894.080.500', 'D23.101.100.110.100.500', 'D23.101.100.894.080.500'], ['C17.800.174.255', 'C17.800.815.255'], ['A11.436.348'], ['D10'], ['A03.620'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Surface activity and redox behavior of a non-ionic surfactant containing a phenothiazine group. | A novel non-ionic surfactant, alpha-(phenothiazinylhexyl)-omega-hydroxy-oligo(ethylene oxide) (PCPEG) containing phenothiazine as an electro-active group has been synthesized. Fundamental interfacial behavior of the surfactant at the air/water interface has been investigated by means of surface tensiometry to provide a... | ['Adsorption', 'Electrochemistry', 'Micelles', 'Oxidation-Reduction', 'Phenothiazines', 'Surface Properties', 'Surface-Active Agents'] | 15,542,320 | [['G01.030', 'G02.020'], ['H01.181.529.307'], ['D05.374', 'D26.255.560'], ['G02.700', 'G03.295.531'], ['D02.886.369', 'D03.633.300.783'], ['G02.860'], ['D27.720.877']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Staining of neuroendocrine cells by Linder's argyrophil method. | Linder's argyrophil method, recently developed to stain nervous structures, is useful in the histochemical study of amine- and/or peptide-producing neuroendocrine (APUD) cells. On sections from various organs of four animal species Linder's method worked well and rapidly stained the neuroendocrine cells yellow, red or ... | ['Animals', 'Coturnix', 'Histocytochemistry', 'Microscopy, Electron', 'Neurosecretory Systems', 'Quail', 'Rabbits', 'Sheep', 'Staining and Labeling'] | 2,461,924 | [['B01.050'], ['B01.050.150.900.248.350.650.350'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['E01.370.350.515.402', 'E05.595.402'], ['A06.688', 'A08.713'], ['B01.050.150.900.248.350.650'], ['B01.050.150.900.649.313... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Transformative Two-Dimensional Array Configurations by Geometrical Shape-Shifting Protein Microstructures. | Two-dimensional (2D) geometrical shape-shifting is prevalent in nature, but remains challenging in man-made "smart" materials, which are typically limited to single-direction responses. Here, we fabricate geometrical shape-shifting bovine serum albumin (BSA) microstructures to achieve circle-to-polygon and polygon-to-c... | ['Animals', 'Cattle', 'Cross-Linking Reagents', 'Equipment Design', 'Hydrogen-Ion Concentration', 'Microfluidics', 'Microtechnology', 'Serum Albumin, Bovine'] | 26,372,201 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D27.720.470.410.210'], ['E05.320'], ['G02.300'], ['E05.830.666', 'H01.671.808.500', 'J01.897.520.500.500'], ['H01.570', 'J01.897.520.500'], ['D12.776.034.841.540', 'D12.776.124.727.875']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
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