Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Are gonadotropin-releasing hormone agonists losing popularity? Current trends at a large fertility center. | OBJECTIVE: To explore the long- and short-term trends in LH-suppression protocol use and patient profile characteristics.DESIGN: Descriptive study, retrospective cohort.SETTING: Large, university-based IVF center.PATIENT(S): Four thousand five hundred one fresh IVF cycles categorized by use of GnRH antagonist, luteal G... | ['Adult', 'Age Factors', 'Embryo Implantation', 'Female', 'Fertility Agents, Female', 'Fertilization in Vitro', 'Gonadotropin-Releasing Hormone', 'Hormone Antagonists', 'Humans', 'Infertility', 'Live Birth', 'Luteinizing Hormone', 'Male', 'Patient Selection', "Practice Patterns, Physicians'", 'Pregnancy', 'Pregnancy Ra... | 18,973,891 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['G08.686.784.170.104.500'], ['D27.505.696.875.552.344', 'D27.505.954.705.552.344'], ['E02.875.800.750', 'E05.820.800.750'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405.740.320'], ['D0... | ['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain. | The neuropeptides/neurotransmitters neurotensin (NT) and neuromedin (NN) are synthesized by endoproteolytic cleavage of a common inactive precursor, pro-NT/NN. In vitro studies have suggested that the prohormone convertases PC5A and PC2 might both be involved in this process. In the present study, we used dual immunohi... | ['Animals', 'Brain', 'Male', 'Neurons', 'Neurotensin', 'Peptide Fragments', 'Proprotein Convertase 2', 'Proprotein Convertase 5', 'Protein Precursors', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Cell Surface', 'Receptors, Fibroblast Growth Factor', 'Serine Endopeptidases', 'Sialoglycoproteins', 'Subtilisins'] | 10,906,713 | [['B01.050'], ['A08.186.211'], ['A08.675', 'A11.671'], ['D12.644.400.550', 'D12.776.631.650.550'], ['D12.644.541'], ['D08.811.277.656.300.760.646', 'D08.811.277.656.837.562', 'D08.811.277.656.959.350.646'], ['D08.811.277.656.300.760.648', 'D08.811.277.656.837.625', 'D08.811.277.656.959.350.648'], ['D12.776.811'], ['B01... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolated liver granulomas of murine Schistosoma mansoni contain components of the angiotensin system. | Angiotensin I (AI) and angiotensin II/III (AII/III) were detected by radioimmunoassay in homogenates of isolated liver granulomas from mice infected for 8 wk with Schistosoma mansoni. Angiotensin I converting enzyme (ACE) activity, which could be completely inhibited by captopril, a specific ACE inhibitor, was also pre... | ['Angiotensin-Converting Enzyme Inhibitors', 'Angiotensinogen', 'Angiotensins', 'Animals', 'Cell Migration Inhibition', 'Dipeptides', 'Enalapril', 'Endopeptidases', 'Female', 'Granuloma', 'Macrophages', 'Mice', 'Mice, Inbred CBA', 'Oligopeptides', 'Peptidyl-Dipeptidase A', 'Schistosoma mansoni', 'Schistosomiasis', 'Tep... | 6,195,268 | [['D27.505.519.389.745.085'], ['D12.644.456.073.070', 'D12.644.861.020', 'D12.776.811.070', 'D12.776.872.020'], ['D06.472.699.094', 'D12.644.400.070', 'D12.644.456.073', 'D12.644.548.058', 'D12.776.631.650.070', 'D23.469.050.050'], ['B01.050'], ['G04.198.337'], ['D12.644.456.345'], ['D12.644.456.345.360'], ['D08.811.27... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
DNA in psoriatic epidermis. | An electron microscopic technique has been used to visualize crosslinks after total denaturation on DNA isolated from epidermis and dermis in patients with psoriasis treated with 8-methoxypsoralen (8-MOP) and irradiation with ultraviolet light at 360 nm (PUVA treatment). This technique facilitated accurate measurements... | ['DNA', 'Epidermis', 'Furocoumarins', 'Humans', 'Methoxsalen', 'Microscopy, Electron', 'Photochemotherapy', 'Psoriasis', 'Skin', 'Ultraviolet Therapy'] | 294,785 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of styrene as sole carbon source by the fungus Exophiala oligosperma: optimization and modeling of biodegradation, pathway elucidation, and cell membrane composition. | Biodegradation of styrene by Exophiala sp. was tested at different initial concentrations (19.3-170.6 mgl(-1)), pH (2.8-8.7), and temperatures (19.8-45.1 °C), for 120 h according to a 2(3) full-factorial central composite design. The specific growth rate (SGR, per hour) and specific styrene utilization rate (SUR, milli... | ['Biodegradation, Environmental', 'Biotechnology', 'Cell Membrane', 'Exophiala', 'Fungal Proteins', 'Hydrogen-Ion Concentration', 'Kinetics', 'Metabolic Networks and Pathways', 'Styrene', 'Temperature'] | 22,961,395 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['H01.158.550', 'J01.897.120'], ['A11.284.149'], ['B01.300.107.366', 'B01.300.381.355'], ['D12.776.354'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['G03.493'], ['D02.455.426.559.389.150.750.800'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06... | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
3D-Printed Isoniazid Tablets for the Treatment and Prevention of Tuberculosis-Personalized Dosing and Drug Release. | The aim of the present work was to produce 3D-printed oral dosage forms with a sufficient drug dose displaying various release profiles. Hot-melt extrusion was utilized to produce drug-loaded feedstock material that was subsequently 3D-printed into 6, 8, and 10 ? 2.5 mm tablets with 15% and 90% infill levels. The prepa... | ['Antitubercular Agents', 'Drug Compounding', 'Drug Delivery Systems', 'Drug Liberation', 'Isoniazid', 'Printing, Three-Dimensional', 'Tablets', 'Technology, Pharmaceutical', 'Tuberculosis'] | 30,617,660 | [['D27.505.954.122.085.255'], ['E05.916.270'], ['E02.319.300'], ['G02.211', 'G03.787.321', 'G07.690.725.321'], ['D02.442.436', 'D03.066.349.410', 'D03.383.725.394.582'], ['J01.897.564', 'L01.224.108.150.500', 'L01.296.110.150.500'], ['D26.255.830'], ['E05.916', 'J01.897.836'], ['C01.150.252.410.040.552.846']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Diseases [C]'] | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Quantitative evaluation of 2 x 2 arrays of Lucite cone applicators in flat layered phantoms using Gaussian-beam-predicted and thermographically measured SAR distributions. | SAR distributions from four different E-field-orientated 2 x 2 arrays of incoherently driven Lucite cone applicators (LCAs) were investigated. The LCAs operated at 433 MHz with an aperture of 10.5 cm x 10.5 cm each. Two techniques were used to obtain SAR distributions in flat layered phantoms: Gaussian beam (GB) predic... | ['Humans', 'Hyperthermia, Induced', 'Models, Theoretical', 'Muscle, Skeletal', 'Phantoms, Imaging', 'Polymethyl Methacrylate', 'Thermography'] | 9,725,599 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.565'], ['E05.599'], ['A02.633.567', 'A10.690.552.500'], ['E07.671'], ['D02.241.081.069.800.550.500', 'D05.750.716.822.111.650.605.500', 'D25.720.716.822.111.650.605.500', 'J01.637.051.720.716.822.111.650.605.500'], ['E01.370.350.800', 'E05.933.500']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Skin biophysical properties of a population living in Valais, Switzerland. | BACKGROUND/PURPOSE: Switzerland has one of the highest rates of skin diseases and particularly skin cancer, in Europe. Skin elastosis, roughness and atopy are also frequent. High UV exposure and prevalence of light skin individuals could be the cause. Valais, in Southern Switzerland, is a mountain region with elevated ... | ['Adolescent', 'Adult', 'Aged', 'Female', 'Humans', 'Hydrogen-Ion Concentration', 'Life Style', 'Middle Aged', 'Reference Values', 'Sebum', 'Skin', 'Skin Physiological Phenomena', 'Switzerland', 'Ultraviolet Rays'] | 14,641,883 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['F01.829.458'], ['M01.060.116.630'], ['E05.978.810'], ['A12.200.702'], ['A17.815'], ['G13.750'], ['Z01.542.883'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659'... | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Geographicals [Z]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Prevalence and antibiotic resistance pattern of Salmonella serovars in integrated crop-livestock farms and their products sold in local markets. | Major concern in the Mixed Crop-Livestock (MCL) farms, in which livestock and vegetables grown closely in the same facility, is cross-contamination of zoonotic bacterial pathogens especially Salmonella. To investigate the distribution of Salmonella serovars in MCL and their products, a total of 1287 pre-harvest samples... | ['Animals', 'Anti-Bacterial Agents', 'Commerce', 'Crops, Agricultural', 'District of Columbia', 'Farms', 'Food Microbiology', 'Livestock', 'Maryland', 'Salmonella'] | 26,914,740 | [['B01.050'], ['D27.505.954.122.085'], ['J01.219'], ['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['Z01.107.567.875.500.210', 'Z01.433.429'], ['J01.040.372', 'J03.540.150'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.300', 'N06.850.425.200', 'N06.850.460.400.300', 'N06.850.601.500.249.300'], ['B01.05... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
Aging and sex-related changes in the biomechanical properties of the rabbit medial collateral ligament. | The effects of aging and sex on the tensile properties of the rabbit medial collateral ligament (MCL) were examined. The femur-MCL-tibia complex (FMTC) of male and female rabbits, of representative ages before and after epiphyseal closure up to the onset of senescence (i.e., 3.5, 6, 12 and 36 months of age) were examin... | ['Aging', 'Animals', 'Biomechanical Phenomena', 'Female', 'Ligaments', 'Male', 'Rabbits', 'Sex Factors', 'Stress, Mechanical', 'Tensile Strength'] | 2,290,352 | [['G07.345.124'], ['B01.050'], ['G01.154.090', 'G01.374.089'], ['A02.513', 'A10.165.669'], ['B01.050.150.900.649.313.968.700'], ['N05.715.350.675', 'N06.850.490.875'], ['G01.374.835'], ['G01.374.850']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cloning and characterization of the katA gene of Rhizobium meliloti encoding a hydrogen peroxide-inducible catalase. | To investigate the involvement of bacterial catalases of the symbiotic gram-negative bacterium Rhizobium meliloti in the development of Medicago-Rhizobium functional nodules, we cloned a putative kat gene by screening a cosmid library with a catalase-specific DNA probe amplified by PCR from the R. meliloti genome. Nucl... | ['Adaptation, Physiological', 'Amino Acid Sequence', 'Base Sequence', 'Catalase', 'Chromosome Mapping', 'Chromosomes, Bacterial', 'Cloning, Molecular', 'Enzyme Induction', 'Gene Library', 'Genes, Bacterial', 'Hydrogen Peroxide', 'Molecular Sequence Data', 'Mutagenesis, Insertional', 'Nitrogen Fixation', 'Phenotype', 'P... | 8,955,300 | [['G07.025', 'G16.012.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.682.732.332'], ['E05.393.183'], ['A11.284.187.190', 'A20.812', 'G05.360.162.190'], ['E05.393.220'], ['G05.308.320.200'], ['G05.360.325'], ['G05.360.340.024.340.364.249', 'G05.360... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
MEG3 interacted with miR-494 to repress bladder cancer progression through targeting PTEN. | The long noncoding RNA MEG3 is a significant tumor-suppressive gene in various tumors. But its biological role in bladder cancer remains uninvestigated. Herein, the biological mechanism of MEG3 in bladder cancer pathogenesis was explored. First, the expression of MEG3 in bladder cancer cells was examined, and we found ... | ['Animals', 'Cell Line, Tumor', 'Down-Regulation', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Mice', 'Mice, Nude', 'MicroRNAs', 'Neoplasms, Experimental', 'PTEN Phosphohydrolase', 'RNA, Long Noncoding', 'Up-Regulation', 'Urinary Bladder Neoplasms'] | 31,294,463 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association between intraoperative electroencephalographic suppression and postoperative mortality. | BACKGROUND: Low bispectral index values frequently reflect EEG suppression and have been associated with postoperative mortality. This study investigated whether intraoperative EEG suppression was an independent predictor of 90 day postoperative mortality and explored risk factors for EEG suppression.METHODS: This obse... | ['Adult', 'Aged', 'Anesthetics, General', 'Blood Pressure', 'Comorbidity', 'Consciousness', 'Electroencephalography', 'Female', 'Humans', 'Male', 'Manitoba', 'Middle Aged', 'Monitoring, Intraoperative', 'Postoperative Complications', 'Prognosis', 'Risk Assessment', 'United States'] | 24,852,500 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.696.277.100.035', 'D27.505.954.427.210.100.035'], ['E01.370.600.875.249', 'G09.330.380.076'], ['N05.715.350.225', 'N06.850.490.687'], ['F02.463.188.409', 'F02.830.233'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.56... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Congenital muscular dystrophies: muscle-eye-brain disease]. | Three rare autosomal recessive disorders share the combination of congenital muscular dystrophy and brain malformations including a neuronal migration defect: muscle-eye-brain disease (MEB), Walker-Warburg syndrome (WWS), and Fukuyama congenital muscular dystrophy (FCMD). In addition, ocular abnormalities are a constan... | ['Brain', 'Child, Preschool', 'Chromosome Mapping', 'Diagnosis, Differential', 'Electromyography', 'Exons', 'Eye Diseases, Hereditary', 'Genes, Recessive', 'Genetic Carrier Screening', 'Humans', 'Hydrocephalus', 'Infant', 'Infant, Newborn', 'Magnetic Resonance Imaging', 'Male', 'Muscle Hypotonia', 'Muscular Dystrophies... | 15,770,576 | [['A08.186.211'], ['M01.060.406.448'], ['E05.393.183'], ['E01.171'], ['E01.370.405.255', 'E01.370.530.255'], ['G05.360.340.024.340.137.232'], ['C11.270', 'C16.320.290'], ['G05.360.340.024.340.415', 'G05.420.325'], ['E01.370.225.562.250', 'E05.200.562.250', 'E05.393.435.250', 'N02.421.308.200', 'N02.421.726.233.221.250'... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Beyond the classroom, 'pro-active teaching methods--a must for today's CPD movement'. | Non-traditional teaching approaches are not recent innovations in the field of continuing medical and professional development; however, there is a lack of employing such methods in our context. The reasons could include lack of awareness, recognition and overlapping and adoption of these approaches, peculiarly academi... | ['Education, Medical, Continuing', 'Humans', 'Leadership', 'Pakistan'] | 24,864,643 | [['I02.358.212.350', 'I02.358.399.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.609'], ['Z01.252.245.723']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
[Evaluation of integrated control measures for soil-transmitted nematodiasis in Jinhu County, Jiangsu Province]. | OBJECTIVE: To evaluate the effect of integrated control measures on soil-transmitted nematodiasis so as to provide the evidence for formulating the appropriate control strategies and measures in Jinhu County, Jiangsu Province.METHODS: Since 1995, the comprehensive control measures were carried out for soil-transmitted ... | ['China', 'Communicable Disease Control', 'Health Education', 'Humans', 'Nematode Infections', 'Prevalence', 'Soil'] | 24,800,572 | [['Z01.252.474.164'], ['N06.850.780.200'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.335.508'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.60... | ['Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Tomato allergy in children and young adults: cross-reactivity with latex and potato. | BACKGROUND: Several studies have shown that allergy to natural rubber latex is associated with cross-reactivity to certain foods such as tomato and potato. The objective was to investigate the clinical and immunologic differences between a group of patients with clinical allergy to tomato and latex and another which ha... | ['Adolescent', 'Adult', 'Allergens', 'Carboxylic Ester Hydrolases', 'Child', 'Child, Preschool', 'Cross Reactions', 'Female', 'Food Hypersensitivity', 'Humans', 'Immunoblotting', 'Immunoglobulin E', 'Infant', 'Latex', 'Latex Hypersensitivity', 'Lycopersicon esculentum', 'Male', 'Middle Aged', 'Plant Proteins', 'Solanum... | 11,736,750 | [['M01.060.057'], ['M01.060.116'], ['D23.050.063'], ['D08.811.277.352.100'], ['M01.060.406'], ['M01.060.406.448'], ['G12.122.281'], ['C20.543.480.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', 'E05.601.470.320'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D12.77... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Using Cox cluster processes to model latent pulse location patterns in hormone concentration data. | Many hormones, including stress hormones, are intermittently secreted as pulses. The pulsatile location process, describing times when pulses occur, is a regulator of the entire stress system. Characterizing the pulse location process is particularly difficult because the pulse locations are latent; only hormone concen... | ['Adrenocorticotropic Hormone', 'Algorithms', 'Bayes Theorem', 'Humans', 'Hydrocortisone', 'Markov Chains', 'Models, Statistical', 'Monte Carlo Method'] | 26,553,914 | [['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['G17.035', 'L01.224.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['B01.050.15... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Genome-wide DNA methylation analysis in precursor B-cells. | DNA methylation is responsible for regulating gene expression and cellular differentiation and for maintaining genomic stability during normal human development. Furthermore, it plays a significant role in the regulation of hematopoiesis. In order to elucidate the influence of DNA methylation during B-cell development,... | ['Cell Differentiation', 'CpG Islands', 'DNA Methylation', 'Fetal Blood', 'Genome-Wide Association Study', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Infant, Newborn', 'Lymphocyte Subsets', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Precursor Cells, B-Lymphoid'] | 25,484,143 | [['G04.152'], ['G02.111.570.080.380.160', 'G05.360.080.380.160', 'G05.360.340.024.159'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.5... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha. | Two novel membrane disintegrin-metalloproteases, ADAM 20 and ADAM 21 were cloned from a human testis cDNA library. Their predicted translation products share 50% sequence identity with each other. Among previously characterized ADAMs, the best similarity was to sperm cell-specific fertilins-alpha and -beta, and meltrin... | ['ADAM Proteins', 'Amino Acid Sequence', 'Base Sequence', 'Cell Fusion', 'Chromosome Mapping', 'Chromosomes, Human, Pair 14', 'Cloning, Molecular', 'Cytoplasm', 'Disintegrins', 'Fertilins', 'Genetic Markers', 'Humans', 'Male', 'Membrane Glycoproteins', 'Membrane Proteins', 'Metalloendopeptidases', 'Molecular Sequence D... | 9,469,942 | [['D08.811.277.656.675.374.102', 'D09.400.430.500', 'D12.776.395.033'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.242.307', 'G04.155'], ['E05.393.183'], ['A11.284.187.520.300.370.380', 'G05.360.162.520.300.370.380'], ['E05.393.220'], ['A11.284.430.214']... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Isoniazid resistant tuberculosis in a school outbreak: the protective effect of BCG. | An outbreak of isoniazid resistant tuberculosis occurred in a large second level school. A total of 1,160 teenage pupils were at risk. Nineteen cases of tuberculosis were diagnosed, 15 were students, 9 of whom were among 251 non-vaccinated students and 6 among 909 vaccinated students. Two cases of miliary tuberculosis,... | ['Adolescent', 'Adult', 'BCG Vaccine', 'Child, Preschool', 'Disease Outbreaks', 'Drug Resistance, Microbial', 'Female', 'Humans', 'Ireland', 'Isoniazid', 'Male', 'Mycobacterium tuberculosis', 'Public Relations', 'Schools', 'Tuberculin Test', 'Tuberculosis, Pulmonary'] | 1,954,998 | [['M01.060.057'], ['M01.060.116'], ['D20.215.894.135.825.100'], ['M01.060.406.448'], ['N06.850.290'], ['G06.225', 'G07.690.773.984.269'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.467', 'Z01.639.587'], ['D02.442.436', 'D03.066.349.410', 'D03.383.725.394.582'], ['B03.510.024.962.500.702', 'B03.510.460.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Di... | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Increased cyclic AMP in cultured vascular smooth muscle cells and relaxation of aortic strips by parathyroid hormone. | The effects of parathyroid hormone (PTH) were examined in three model systems to determine the mechanism of PTH action in vascular tissue. Bovine parathyroid extract and synthetic bPTH-(1-34) relaxed norepinephrine-contracted rabbit aortic strips in a dose-dependent fashion. The ED50 was 33.1 nM (21.8-50.1 nM). The hyp... | ['1-Methyl-3-isobutylxanthine', 'Adenylyl Cyclases', 'Animals', 'Aorta, Thoracic', 'Cattle', 'Colforsin', 'Cyclic AMP', 'Drug Synergism', 'In Vitro Techniques', 'Male', 'Muscle Relaxation', 'Muscle, Smooth, Vascular', 'Papaverine', 'Parathyroid Hormone', 'Rabbits', 'Sodium Fluoride', 'Time Factors'] | 2,414,115 | [['D03.633.100.759.758.824.751.500'], ['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['A07.015.114.056.372'], ['B01.050.150.900.649.313.500.380.271'], ['D02.455.849.291.300'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['G07.690.773.968... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Five-year follow-up after balloon pulmonary valvuloplasty. | OBJECTIVES: The aim of this study was to assess results 5 years after balloon pulmonary valvuloplasty.BACKGROUND: Since the technique of balloon pulmonary valvuloplasty was first reported in 1982, it has become the treatment of choice for pulmonary valve stenosis. In contrast to surgical valvotomy, the long-term outcom... | ['Blood Pressure', 'Cardiac Catheterization', 'Catheterization', 'Echocardiography', 'Follow-Up Studies', 'Heart Ventricles', 'Humans', 'Infant, Newborn', 'Noonan Syndrome', 'Pulmonary Valve', 'Pulmonary Valve Stenosis', 'Systole', 'Time Factors'] | 8,417,053 | [['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E02.148', 'E05.157'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A07.541.560'], ['B01.050.150.900... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A physiologically based pharmacokinetic computer model for human pregnancy. | A physiologically based pharmacokinetic (PBPK) model for human pregnancy must incorporate many factors that are not usually encountered in PBPK models of mature animals. Models for pregnancy must include the large changes that take place in the mother, the placenta and the embryo/fetus over the period of pregnancy. The... | ['Abnormalities, Drug-Induced', 'Animals', 'Body Fluid Compartments', 'Computer Simulation', 'Drug Interactions', 'Female', 'Fetus', 'Humans', 'Liver', 'Models, Biological', 'Organ Size', 'Pharmacokinetics', 'Placenta', 'Pregnancy', 'Regional Blood Flow', 'Teratogens', 'Tissue Distribution'] | 8,016,750 | [['C16.131.042'], ['B01.050'], ['A10.082', 'A12.207.180'], ['L01.224.160'], ['G07.690.773.968'], ['A16.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['E05.599.395'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['G03.787', 'G07.690.725'], ['A16.710'], ['G0... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Association of polymorphisms in base excision repair genes with the risk of breast cancer: a case-control study in North Indian women. | Inheritance of common genetic variants at one or more base excision repair (BER) genes may result in a reduced DNA repair capacity and in an increased risk of cancers like breast cancer. The present case-control study with 390 north Indian women (155 breast cancer cases and 235 controls) was aimed to investigate the as... | ['Breast Neoplasms', 'Case-Control Studies', 'DNA Repair', 'DNA-(Apurinic or Apyrimidinic Site) Lyase', 'DNA-Binding Proteins', 'European Continental Ancestry Group', 'Female', 'Flap Endonucleases', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'India', 'Polymorphism, Genetic', 'Surveys and Questionnaires'... | 18,669,164 | [['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G02.111.222', 'G05.219'], ['D08.811.074.750', 'D08.811.520.241.225'], ['D12.776.260'], ['M01.686.508.400'], ['D08.811.277.352.355.325.350'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.05... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Sleep Evaluation in the Assessment of Pediatric Attention Deficit Disorders. | INTRODUCTION: Examining the impact of appropriate sleep evaluation on diagnosis of attention deficit disorders can improve the standard of care in pediatrics. This quality improvement project examined current practice and subsequent implementation of a validated standardized sleep evaluation tool in the assessment of c... | ['Adolescent', 'Attention Deficit Disorder with Hyperactivity', 'Child', 'Female', 'Humans', 'Male', 'Mass Screening', 'Practice Guidelines as Topic', 'Quality Improvement', 'Retrospective Studies', 'Sleep Wake Disorders', 'Surveys and Questionnaires', 'United States'] | 30,466,794 | [['M01.060.057'], ['F03.625.094.150'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['N04.761.700.350.650', 'N05.700.350.650'], ['J01.293.754', 'N04.76... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Adult hippocampal neurogenesis in neuropathic pain and alkyl glycerol ethers treatment. | Neuropathic pain manifested by a number of sensory symptoms is often accompanied by disorders of higher nervous activity, such as memory impairment, depression, anxiety, anhedonia, etc. This emphasizes the involvement of supraspinal structures including the hippocampus in neuropathic pain pathogenesis. In the present s... | ['Animals', 'Glyceryl Ethers', 'Hippocampus', 'Male', 'Mice', 'Neuralgia', 'Neurogenesis'] | 29,107,326 | [['B01.050'], ['D02.033.800.875.875', 'D02.355.460'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313.992.635.505.500'], ['C10.668.829.600', 'C23.888.592.612.664'], ['G04.152.912', 'G07.345.500.325.377.687', 'G08.686.784.170.450.500', 'G11.561.620']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Culturally specific dance to reduce obesity in African American women. | This article provides evidence of a culturally specific dance intervention to decrease obesity as measured by body fat and body mass index (BMI) in African American women. A community partnership was formed with two African American churches to develop an intervention to address the issue of obesity. The culturally spe... | ['Adiposity', 'Adult', 'African Americans', 'Aged', 'Aged, 80 and over', 'Body Mass Index', 'Case-Control Studies', 'Community Networks', 'Cultural Competency', 'Dance Therapy', 'Exercise Therapy', 'Female', 'Humans', 'Middle Aged', 'Obesity', 'Protestantism'] | 19,098,267 | [['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.50... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
[Infectious aneurysms of the cavernous carotid artery]. | We describe 3 patients who developed infectious aneurysms of the cavernous carotid artery. The aneurysms were due to sphenoidal sinusitis in two patients and due to endocarditis in one. The acute and septic onset of the cavernous sinus syndrome, suggested thrombophlebitis of the cavernous sinus in all 3 patients. The d... | ['Adult', 'Aged', 'Aneurysm, Infected', 'Carotid Artery Diseases', 'Carotid Artery, Internal', 'Cavernous Sinus', 'Cerebral Angiography', 'Embolization, Therapeutic', 'Female', 'Follow-Up Studies', 'Humans', 'Intracranial Aneurysm', 'Male', 'Sinus Thrombosis, Intracranial', 'Time Factors', 'Tomography, X-Ray Computed'] | 10,916,009 | [['M01.060.116'], ['M01.060.116.100'], ['C01.069', 'C14.907.055.131'], ['C10.228.140.300.200', 'C14.907.253.123'], ['A07.015.114.186.200.230'], ['A07.015.908.224.334'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700.560.180', 'E01.370.370.050.180', 'E01.370.376.537.750.180', 'E05.629.937.180'],... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ethnic and racial differences in the smoking-related risk of lung cancer. | BACKGROUND: There is remarkable variation in the incidence of lung cancer among ethnic and racial groups in the United States.METHODS: We investigated differences in the risk of lung cancer associated with cigarette smoking among 183,813 African-American, Japanese-American, Latino, Native Hawaiian, and white men and wo... | ['African Americans', 'Age Factors', 'Asian Americans', 'Carcinoma', 'European Continental Ancestry Group', 'Female', 'Hawaii', 'Hispanic Americans', 'Humans', 'Incidence', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Oceanic Ancestry Group', 'Risk', 'Smoking', 'United States'] | 16,436,765 | [['M01.686.508.100.100', 'M01.686.754.100'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.686.508.200.100', 'M01.686.754.225'], ['C04.557.470.200'], ['M01.686.508.400'], ['Z01.107.567.875.580.375', 'Z01.639.760.815.482'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375',... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Injury patterns in young, non-professional dancers. | The aim of the present study was to assess the prevalence and types of injuries in 1336 young, non-professional female dancers (age 8-16 years) who participated in a descriptive mixed (cross-sectional/ longitudinal) cohort study. Previous and current injuries were diagnosed and later classified into seven major categor... | ['Adolescent', 'Age Factors', 'Ankle Injuries', 'Athletes', 'Athletic Injuries', 'Child', 'Cross-Sectional Studies', 'Dancing', 'Female', 'Humans', 'Knee Injuries', 'Longitudinal Studies', 'Prevalence', 'Tendinopathy'] | 21,086,212 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['C26.558.100'], ['M01.072'], ['C26.115'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I03.450.642.287'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.558.554'], ['E05.318.372.500.750.500', 'N05.715... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Relationships between physical activity and plasma leptin levels in healthy children: the Fleurbaix-Laventie Ville Sant? II Study. | OBJECTIVE: To study the relationships between physical activity and plasma leptin levels in children from a population-based study, taking into account puberty stages.DESIGN: Subjects were part of the Fleurbaix-Laventie Ville Sant? (FLVS) II Study, a longitudinal study on the determinants of weight gain in children and... | ['Adolescent', 'Aging', 'Anthropometry', 'Child', 'Fasting', 'Female', 'Humans', 'Insulin', 'Leptin', 'Longitudinal Studies', 'Male', 'Motor Activity', 'Puberty', 'Sex Characteristics', 'Skinfold Thickness'] | 15,314,633 | [['M01.060.057'], ['G07.345.124'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['M01.060.406'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['D06.472.699.042.500', 'D12.644.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data. | BACKGROUND: Kallikrein 15 (KLK15)/Prostinogen is a plausible candidate for prostate cancer susceptibility. Elevated KLK15 expression has been reported in prostate cancer and it has been described as an unfavorable prognostic marker for the disease.OBJECTIVES: We performed a comprehensive analysis of association of vari... | ['Adult', 'Aged', 'Aged, 80 and over', 'Base Sequence', 'Chromosome Mapping', 'Computational Biology', 'Databases, Genetic', 'Demography', 'Genetic Predisposition to Disease', 'Genome-Wide Association Study', 'Humans', 'Kallikreins', 'Linkage Disequilibrium', 'Male', 'Middle Aged', 'Polymorphism, Single Nucleotide', 'P... | 22,132,073 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['H01.158.273.180', 'L01.313.124'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['C23.550.291.687.500', 'G05.380.355'], [... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Dru... | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Giant axonal neuropathy caused by a novel compound heterozygous mutation in the gigaxonin gene. | Giant axonal neuropathy is a rare autosomal recessive disorder, which typically involves both central and peripheral nervous system. Yet the phenotypic-genotypic correlation remains obscure. We report a novel compound heterozygous mutation with the c. 805C>T in exon 4(Arg545His missense mutation) and the c. 1634G>A in ... | ['Child', 'Cytoskeletal Proteins', 'Female', 'Giant Axonal Neuropathy', 'Humans', 'Mutation', 'Nerve Fibers, Myelinated'] | 23,248,352 | [['M01.060.406'], ['D12.776.220'], ['C10.500.300.490', 'C10.574.500.495.490', 'C10.668.829.325', 'C10.668.829.800.300.490', 'C16.131.666.300.490', 'C16.320.400.375.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['A08.675.542.512', 'A11.671.501.512', 'A11.671.514']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Stages of primary pupil-block chronic angle-closure glaucoma]. | In China, primary pupil-block chronic angle-closure glaucoma is a blinding eye disease of high incidence in primary glaucoma, with different clinical course and features from acute angle-closure glaucoma. Based on the conditions of the anterior chamber angle, the level of IOP, the defects in optic disc and visual field... | ['Anterior Chamber', 'Chronic Disease', 'Glaucoma, Angle-Closure', 'Humans', 'Intraocular Pressure', 'Optic Disk', 'Pupil', 'Visual Fields'] | 8,404,354 | [['A09.371.060.067'], ['C23.550.291.500'], ['C11.525.381.056'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['A09.371.060.450.780', 'A09.371.894.513.780'], ['F02.463.593.932.934', 'G14.950']] | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MicroRNAs in sputum specimen as noninvasive biomarkers for the diagnosis of nonsmall cell lung cancer: An updated meta-analysis. | BACKGROUND: Nonsmall cell lung cancer (NSCLC) is a serious leading cause of death worldwide. Recently, multiple researches have identified that microRNA (miRNA) in sputum could be a useful tool for NSCLC diagnosis. The objective of this study was to assess whether aberrant miRNA expression could be regarded as a useful... | ['Biomarkers', 'Carcinoma, Non-Small-Cell Lung', 'Humans', 'Lung Neoplasms', 'MicroRNAs', 'Sputum'] | 30,732,158 | [['D23.101'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['A12.200.808']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Incident HIV infection and perinatal transmission rates among HIV negative pregnant women who retested in labor in a tertiary health centre, South East Nigeria. | Background: To reduce the number of new HIV infections among children, retesting of HIV negative pregnant women in labor to identify new infections and instituting appropriate modified obstetrics practices (MOP) has a huge role to play.Aims and Objectives: This study evaluated the HIV sero-positivity in labor among pre... | ['Adult', 'Antibodies, Viral', 'Female', 'HIV Infections', 'HIV Seropositivity', 'Humans', 'Infant', 'Infant, Newborn', 'Infectious Disease Transmission, Vertical', 'Labor, Obstetric', 'Male', 'Mass Screening', 'Nigeria', 'Parturition', 'Polymerase Chain Reaction', 'Pregnancy', 'Pregnancy Complications, Infectious', 'P... | 31,607,722 | [['M01.060.116'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['C01.221.250.875.500', 'C01.221.812.640.400.500', 'C01.778.640.400.500', 'C01.925.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A randomized placebo-controlled study to evaluate the effects of oral albuterol on pulmonary mechanics in ventilator-dependent infants at risk of developing BPD. | Albuterol is a specific beta-2 agonist that has been reported to be effective in treating infants and children with bronchospastic pulmonary disease. The use of oral albuterol has not been investigated in patients with bronchopulmonary dysplasia (BPD). Thirty premature infants were randomized to receive oral albuterol ... | ['Albuterol', 'Bronchopulmonary Dysplasia', 'Caffeine', 'Double-Blind Method', 'Heart Rate', 'Humans', 'Infant, Newborn', 'Prospective Studies', 'Respiration', 'Respiration, Artificial', 'Respiratory Function Tests', 'Respiratory Mechanics'] | 1,852,516 | [['D02.033.100.291.057', 'D02.092.063.291.057', 'D02.092.471.683.061'], ['C08.381.520.750.500', 'C16.614.521.125'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[The effect of many years of hemodialysis therapy on hypophyseal-gonadal axis function in males with chronic renal insufficiency]. | The study aims at evaluating an effect of hemodialyses duration on LH, FSH, and testosterone secretion in males with chronic renal insufficiency. Secretion of these hormones was assessed with LH-RH stimulation test in 41 men with chronic renal insufficiency and 15 healthy controls. Increased LH and FSH and decreased te... | ['Adult', 'Follicle Stimulating Hormone', 'Humans', 'Kidney Failure, Chronic', 'Luteinizing Hormone', 'Male', 'Renal Dialysis', 'Testosterone'] | 8,756,737 | [['M01.060.116'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['D06.472.699.322.576.463', 'D06.472.699.631.525.343.463', 'D12.644.548.691.525.343.463'], ['E02.870.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pain management after total hip arthroplasty at five different Danish hospitals: A prospective, observational cohort study of 501 patients. | BACKGROUND: The available literature does not present a "gold standard" for post-operative pain treatment after total hip arthroplasty (THA). The aim of this prospective observational study was to explore and document post-operative pain treatment, including outcomes, in a large cohort of patients undergoing THA at fiv... | ['Aged', 'Aged, 80 and over', 'Analgesics, Non-Narcotic', 'Analgesics, Opioid', 'Arthroplasty, Replacement, Hip', 'Cohort Studies', 'Denmark', 'Early Ambulation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Morphine', 'Pain Management', 'Pain, Postoperative', 'Prospective Studies', 'Treatment Outcome'] | 30,883,668 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.663.850.014.040', 'D27.505.954.427.040.100'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['E05.318.372.500.75... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Iterative optimal design of PET experiments for estimating beta-adrenergic receptor concentration. | To estimate in vivo myocardial beta-adrenergic receptor concentration with sufficient precision and to reduce the experimental complexities in positron emission tomography (PET), an iterative optimal design method is applied. An initial three-injection protocol, utilising [F-18]-labelled (R)- and (S)-fluorocarazolol an... | ['Adrenergic beta-Antagonists', 'Animals', 'Carbazoles', 'Female', 'Heart', 'Male', 'Models, Chemical', 'Myocardium', 'Propanolamines', 'Receptors, Adrenergic, beta', 'Swine', 'Tomography, Emission-Computed'] | 11,217,875 | [['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['B01.050'], ['D03.633.100.473.144', 'D03.633.300.148'], ['A07.541'], ['E05.599.495'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['D02.033.100.624', 'D02.033.755.624', 'D02.092.063.624'], ['D12.776.543.750.670.300.300.340', 'D12.776.543.750.695.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The unfolding: scenario planning in nursing. | An interdisciplinary consortium organized a group to explore the meaning and the future of nursing in South Dakota using scenario planning. This column provides a general description of the four scenarios that emerged, some observations about how they might evolve, comments on their implications, and first-person stori... | ['Forecasting', 'Human Development', 'Humans', 'Models, Nursing', 'Needs Assessment', 'Nursing', 'Nursing Research', 'Planning Techniques', 'Science', 'South Dakota', 'Technology Assessment, Biomedical', 'Workforce'] | 12,593,311 | [['I01.320'], ['F01.525', 'G07.345.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.645'], ['I02.594', 'N03.349.380.565', 'N05.300.537'], ['H02.478', 'N04.452.758.377'], ['H01.770.644.145.390', 'H02.478.395', 'N04.590.233.508.613'], ['N04.452.718'], ['H01.770'], ['Z01.107.567.875.510.700'], ['N03.880',... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Preparation of a spectral probe derivative of the hemocyanin biopolymer: effects of allosteric interactions on the coupled binuclear copper active site. | A series of derivatives for both the arthropod and mollusc hemocyanin biopolymers has been prepared; the derivatives contain a small fraction of electron paramagnetic resonance-detectable half-met [Cu(II) CU(I)] sites dispersed among the non-detectable oxy binuclear copper active sites. Upon deoxygenation, large change... | ['Allosteric Site', 'Animals', 'Arthropods', 'Binding Sites', 'Copper', 'Electron Spin Resonance Spectroscopy', 'Hemocyanins', 'Horseshoe Crabs', 'Macromolecular Substances', 'Protein Binding'] | 6,283,534 | [['G02.111.570.120.147'], ['B01.050'], ['B01.050.500.131'], ['G02.111.570.120'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E05.196.867.519.274'], ['D12.776.093.375', 'D12.776.556.462', 'D23.767.482'], ['B01.050.500.131.450'], ['D05'], ['G02.111.679', 'G03.808']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Health economic burden that different wound types impose on the UK's National Health Service. | The aim of this study was to estimate the patterns of care and annual levels of health care resource use attributable to the management of different wound types by the UK's National Health Service (NHS) in 2012/2013 and the annual costs incurred by the NHS in managing them. This was a retrospective cohort analysis of t... | ['Cohort Studies', 'Cost-Benefit Analysis', 'Female', 'Health Care Costs', 'Humans', 'Male', 'Retrospective Studies', 'State Medicine', 'United Kingdom', 'Wound Healing', 'Wounds and Injuries'] | 27,229,943 | [['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N03.219.151.125'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Central projections of sensory systems involved in honey bee dance language communication. | Honey bee dance language is a unique and complex form of animal communication used to inform nest mates in the colony about the specific location of food sources or new nest sites. Five different sensory systems have been implicated in acquiring and communicating the information necessary for dance language communicati... | ['Afferent Pathways', 'Animal Communication', 'Animals', 'Appetitive Behavior', 'Bees', 'Behavior, Animal', 'Neurons, Afferent', 'Sense Organs'] | 17,519,525 | [['A08.612.220'], ['F01.145.113.055'], ['B01.050'], ['F01.145.113.111'], ['B01.050.500.131.617.720.500.500.875.387'], ['F01.145.113'], ['A08.675.650', 'A11.671.650'], ['A09']] | ['Anatomy [A]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A budget impact model for paclitaxel-eluting stent in femoropopliteal disease in France. | PURPOSE: The Zilver PTX drug-eluting stent (Cook Ireland Ltd., Limerick, Ireland) represents an advance in endovascular treatments for atherosclerotic superficial femoral artery (SFA) disease. Clinical data demonstrate improved clinical outcomes compared to bare-metal stents (BMS). This analysis assessed the likely imp... | ['Arterial Occlusive Diseases', 'Atherosclerosis', 'Budgets', 'Drug-Eluting Stents', 'Femoral Artery', 'France', 'Health Care Costs', 'Humans', 'Models, Economic', 'Paclitaxel', 'Peripheral Vascular Diseases', 'Popliteal Artery'] | 23,073,560 | [['C14.907.137'], ['C14.907.137.126.307'], ['N03.219.463.060'], ['E07.695.750.500'], ['A07.015.114.351'], ['Z01.542.286'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.600', 'E05.599.835.890', 'N05.715.360.750.530.500', 'N06.850.520.830.500.600'], ['D02.455.426.... | ['Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Core-shell hierarchical mesostructured silica nanoparticles for gene/chemo-synergetic stepwise therapy of multidrug-resistant cancer. | The design and synthesis of hierarchically nanoporous structures for the co-encapsulation and sequential releases of different cargos are still great challenges in biomedical applications. In this work, we report on the elaborate design and controlled synthesis of a unique core-shell hierarchical mesoporous silica/orga... | ['Animals', 'Doxorubicin', 'Drug Carriers', 'Drug Delivery Systems', 'Drug Resistance, Neoplasm', 'Female', 'Humans', 'MCF-7 Cells', 'Mammary Neoplasms, Experimental', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Nanoparticles', 'RNA, Small Interfering', 'Silicon Dioxide'] | 28,441,616 | [['B01.050'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['D26.255.260', 'E02.319.300.380'], ['E02.319.300'], ['G07.690.773.984.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.630'], ['C04.588.531.500', 'C04.619.590', 'E05.598.500.496.843'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Phosphono analogues of glutathione as new inhibitors of glutathione S-transferases. | Phosphono-analogues of glutathione containing the O = P(OR)2 moiety in place of the cysteinyl residue CH2SH 1a-1d were prepared by solution phase peptide synthesis. Benzyl, benzyloxy-carbonyl, and tert-butyl protecting groups were used to mask the individual amino acid functional groups. The formation of peptide bonds ... | ['Enzyme Inhibitors', 'Glutathione', 'Glutathione Transferase', 'Humans'] | 8,997,900 | [['D27.505.519.389'], ['D12.644.456.448'], ['D08.811.913.225.500'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The 33 carboxyl-terminal residues of Spa40 orchestrate the multi-step assembly process of the type III secretion needle complex in Shigella flexneri. | The type III secretion apparatus (T3SA) is a central virulence factor of many Gram-negative bacteria. Its overall morphology consists of a cytoplasmic region, inner- and outer-membrane sections and an extracellular needle. In Shigella, the length of the needle is regulated by Spa32. To understand better the role of Spa... | ['Amino Acid Motifs', 'Amino Acid Sequence', 'Bacterial Proteins', 'Bacterial Secretion Systems', 'Gene Expression Regulation, Bacterial', 'Membrane Proteins', 'Molecular Sequence Data', 'Protein Binding', 'Protein Structure, Tertiary', 'Protein Transport', 'Shigella flexneri', 'Virulence Factors'] | 20,507,885 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['D05.500.890.500'], ['G05.308.300'], ['D12.776.543'], ['L01.453.245.667'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709.610'], ['G03.143.700'], ['B03.440.450.425.850.450', 'B03.660.250.150... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The Effectiveness of the Within Our Reach Relationship Education Program for Couples: Findings from a Federal Randomized Trial. | This study examined the effectiveness of a couple-based relationship education program, Within Our Reach. Secondary data (n = 3,609) were analyzed from the federal Supporting Healthy Marriage project. Couples were randomly assigned to receive Within Our Reach and associated services or to a no-treatment (treatment-as-u... | ['Adult', 'Communication', 'Cooperative Behavior', 'Education, Nonprofessional', 'Emotions', 'Family Characteristics', 'Female', 'Follow-Up Studies', 'Happiness', 'Humans', 'Interpersonal Relations', 'Intimate Partner Violence', 'Male', 'Marital Status', 'Parenting', 'Stress, Psychological'] | 25,787,758 | [['M01.060.116'], ['F01.145.209', 'L01.143'], ['F01.145.813.115'], ['I02.233'], ['F01.470'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.224.361', 'N01.824.308', 'N06.850.505.400.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['F01.470.516'], ['B01.0... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Low dose intrathecal ropivacaine with or without sufentanil provides effective analgesia and does not impair motor strength during labour: a pilot study. | PURPOSE: Although ropivacaine has been used to provide spinal anesthesia in the surgical population, its intrathecal administration for labour analgesia has only recently been described. We evaluated the effects of low dose intrathecal ropivacaine with or without sufentanil for labour analgesia.METHODS: Thirty-six term... | ['Adjuvants, Anesthesia', 'Adult', 'Amides', 'Analgesia, Obstetrical', 'Anesthesia, Spinal', 'Anesthetics, Local', 'Double-Blind Method', 'Female', 'Humans', 'Injections, Spinal', 'Labor, Obstetric', 'Pain Measurement', 'Pilot Projects', 'Pregnancy', 'Ropivacaine', 'Sufentanil'] | 11,495,875 | [['D27.505.954.427.010'], ['M01.060.116'], ['D02.065'], ['E03.091.110'], ['E03.155.086.331'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E0... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Assessment of a blood preservation protocol for use in ferrets before transfusion. | Blood transfusion has been described in ferrets as a treatment for oestrus-associated anaemia and as a life-saving therapy following trauma, iatrogenic (usually surgery-induced) anaemia, autoimmune haemolytic anaemia and pure red cell aplasia. Although blood banking is a common method for storage of feline and canine b... | ['Adenine', 'Animals', 'Anticoagulants', 'Blood Preservation', 'Blood Transfusion', 'Citrates', 'Cold Temperature', 'Erythrocytes', 'Ferrets', 'Glucose', 'In Vitro Techniques', 'Male', 'Phosphates', 'Polyethylene Terephthalates', 'Time Factors'] | 24,523,302 | [['D03.633.100.759.138'], ['B01.050'], ['D27.505.954.502.119'], ['E02.792.833.230', 'E05.760.833.230'], ['E02.095.135'], ['D02.241.081.901.434'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['A11.118.290', 'A11.443.240', 'A15.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Development of immune responsiveness to Ascaris suum antigens in pigs vaccinated with ultraviolet-attenuated eggs. | Pigs fed Ascaris suum eggs attenuated by short wave ultraviolet-radiation developed resistance to challenge infection. Per os inoculation of pigs on three successive weeks with 10,000 eggs irradiated to total exposures of 150,100 and 75 microW-min/cm2, respectively, resulted in an 88% reduction in the number of larvae ... | ['Animals', 'Antigens', 'Ascaris', 'Female', 'Ovum', 'Swine', 'Ultraviolet Rays', 'Vaccination', 'Vaccines, Attenuated'] | 6,889,778 | [['B01.050'], ['D23.050'], ['B01.050.500.500.294.400.500.100.108'], ['A05.360.490.690', 'A11.497.497', 'A16.690'], ['B01.050.150.900.649.313.500.880'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G16.500.275.063.725.525.600', 'G16.500.750.775.525.600'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Synaptophysin immunoreactivity and small clear vesicles in neuroendocrine cells and related tumours. | Synaptophysin (protein p38) immunoreactivity has been detected immunohistochemically in neuroendocrine cells of the human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas and gastrointestinal mucosa as well as in 87 out of 93 neuroendocrine tumours investigated, including pheochromocytomas, chrom... | ['Chromogranin A', 'Chromogranins', 'Cytoplasmic Granules', 'Humans', 'Immunohistochemistry', 'Infant', 'Membrane Proteins', 'Microscopy, Electron', 'Neoplasms', 'Neurosecretory Systems', 'Pancreas', 'Pituitary Gland', 'Synaptophysin'] | 3,134,611 | [['D12.776.631.199.249'], ['D12.776.631.199', 'D12.776.811.185'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512'... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
How college students diagnosed with anxiety disorders and/or depression use everyday technology. | Anxiety disorders and/or depression are the most frequently diagnosed mental health problems (MHP) among American college students. Everyday technology (EDT) is being used with those who have MHP to help them cope with the mental/cognitive disabilities arising from having anxiety and/or depression. Deveau investigated ... | ['Adolescent', 'Anxiety Disorders', 'Depression', 'Female', 'Humans', 'Male', 'Microcomputers', 'Mobile Applications', 'Self-Help Devices', 'Smartphone', 'Students', 'Surveys and Questionnaires', 'Universities', 'Young Adult'] | 30,318,942 | [['M01.060.057'], ['F03.080'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.260.550'], ['L01.224.900.685'], ['E07.796'], ['L01.178.847.698.300.250', 'L01.224.230.260.550.500.750'], ['M01.848'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['I02.783.830', 'J03... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 |
[Virtual endoscopy view of ossicular chain in the congenital aural atresia]. | OBJECTIVE: To investigate the function of virtual endoscopy in assessing ossicular chain deformity in the congenital ear malformation.METHOD: In 23 cases 28 ears with congenital atresia of external auditory meatus. A high resolution spiral CT is used to display the temporal bone by axial and direct coronal planes. Pers... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Ear Canal', 'Ear Diseases', 'Ear Ossicles', 'Ear, External', 'Ear, Middle', 'Endoscopy', 'Female', 'Humans', 'Imaging, Three-Dimensional', 'Infant', 'Software', 'Tomography, Spiral Computed', 'Young Adult'] | 17,580,714 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['A09.246.272.396'], ['C09.218'], ['A09.246.397.247'], ['A09.246.272'], ['A09.246.397'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['M01.060.703'], ['L01.224.900'],... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS). | Tuberculosis is still a leading cause of morbidity and mortality worldwide. Improvements to existing drug regimens and the development of novel therapeutics are urgently required. The ability of dosed TB drugs to reach and sterilize bacteria within poorly-vascularized necrotic regions (caseum) of pulmonary granulomas i... | ['Animals', 'Antitubercular Agents', 'Chromatography, Liquid', 'Ethambutol', 'Female', 'Laser Capture Microdissection', 'Lung', 'Male', 'Rabbits', 'Tandem Mass Spectrometry', 'Tuberculosis, Pulmonary'] | 29,733,325 | [['B01.050'], ['D27.505.954.122.085.255'], ['E05.196.181.400'], ['D02.092.782.258.368.265'], ['E01.370.225.998.221.580.500', 'E05.200.998.221.580.500', 'E05.591.560.500'], ['A04.411'], ['B01.050.150.900.649.313.968.700'], ['E05.196.566.880'], ['C01.150.252.410.040.552.846.899', 'C01.748.939', 'C08.381.922', 'C08.730.93... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Clinical study on the endothelial immune rejection after penetrating keratoplasty]. | OBJECTIVE: To study the relationship between the grafts transparency and the endothelial immune rejection at different periods after penetrating keratoplasty (PKP).METHODS: A following-up was performed on patients received PKP in Shandong Eye Institute and Hospital between January 1994 and December 1998. A total of 648... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Child, Preschool', 'Corneal Diseases', 'Endothelium, Corneal', 'Female', 'Follow-Up Studies', 'Graft Rejection', 'Humans', 'Infant', 'Keratoplasty, Penetrating', 'Male', 'Middle Aged'] | 15,840,342 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['C11.204'], ['A09.371.060.067.318', 'A09.371.060.217.318', 'A10.272.491.318'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G12.875.545.328'], ['B01.050.150.900.649.313.988.400.... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Molecular cloning of the coding sequence of an interleukin-2 receptor alpha subunit cDNA in murine brain. | Interleukin-2 (IL-2) has various trophic and neuromodulatory actions in the mammalian central nervous system (CNS). The interleukin-2 receptor alpha (IL-2R alpha) is an accessory subunit of the IL-2 receptor heterotrimer complex which is essential for 'high' affinity IL-2 binding. Although an IL-2R alpha (or IL-2R alph... | ['Animals', 'Base Sequence', 'Cloning, Molecular', 'DNA, Complementary', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred NOD', 'Mice, SCID', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Prosencephalon', 'RNA, Messenger', 'Receptors, Interleukin-2'] | 7,797,614 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['B01.050.050.199.520.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
High-risk alcohol use and associated socio-demographic, health and psychosocial factors in patients with HIV infection in three primary health care clinics in South Africa. | Alcohol use may have a negative impact on the course of HIV disease and the effectiveness of its treatment. We studied patients with HIV who use alcohol and associated socio-demographic, health and psychosocial factors. Outcomes from this study may help in selecting patients from clinical practice with high-risk alcoho... | ['Adolescent', 'Adult', 'Alcohol Drinking', 'Alcoholism', 'Antiretroviral Therapy, Highly Active', 'Cross-Sectional Studies', 'Female', 'HIV Infections', 'Humans', 'Male', 'Middle Aged', 'Prevalence', 'Primary Health Care', 'Quality of Life', 'Risk Factors', 'South Africa', 'Surveys and Questionnaires'] | 27,448,655 | [['M01.060.057'], ['M01.060.116'], ['F01.145.317.269'], ['C25.775.100.250', 'F03.900.100.350'], ['E02.319.310.075'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Research on the determination method of trace amount of Pb and Cd in animal bone]. | A method for the determination of trace amount of Pb and Cd in animal bone using GFAAS has been established. The samples were determined directly after being diluted by TMAH solution. The method is handy and fast. The recovery is 96.95-103.15%. The RSD is less than 4.81%. | ['Analytic Sample Preparation Methods', 'Animals', 'Bone and Bones', 'Cadmium', 'Calibration', 'Lead', 'Temperature'] | 15,810,285 | [['E05.196.059'], ['B01.050'], ['A02.835.232', 'A10.165.265'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['E05.978.155'], ['D01.268.556.435', 'D01.552.544.435'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Mechanisms in in vivo release of lymphokines. III. Separation of gamma-interferon (IFN gamma) from cytotoxicity in inbred strains of mice. | Inbred strains of mice sensitized with BCG and challenged with old tuberculin (OT) vary in their capacity to release IFN gamma and MIF into circulation. Experiments were performed to correlate the presence of IFN gamma with that of the cytotoxic effect in an attempt to learn whether these two activities in the sera may... | ['Adjuvants, Immunologic', 'Animals', 'Cell Division', 'Cytotoxicity, Immunologic', 'Interferons', 'Lymphokines', 'Macrophage Migration-Inhibitory Factors', 'Mice', 'Mice, Inbred Strains'] | 6,180,068 | [['D27.505.696.477.067'], ['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G12.287'], ['D12.644.276.374.440', 'D12.776.467.374.440', 'D23.529.374.440'], ['D12.644.276.374.480', 'D12.776.467.374.480', 'D23.529.374.480'], ['D12.644.276.374.480.625', 'D12.776.467.374.480.625', 'D23.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Single-channel properties of the sarcoplasmic reticulum calcium-release channel in slow- and fast-twitch muscles of Rhesus monkeys. | RyR1 is the main isoform of ryanodine receptor expressed in fast- and slow-twitch mammalian skeletal muscles although differences in Ca2+-release kinetics and properties have been reported. Single-channel measurements reveal that a large proportion (82%) of Ca2+-release channels measured in slow-twitch muscle preparati... | ['Animals', 'Caffeine', 'Calcium', 'Electrophysiology', 'In Vitro Techniques', 'Macaca mulatta', 'Muscle Fibers, Fast-Twitch', 'Muscle Fibers, Slow-Twitch', 'Muscle, Skeletal', 'Ryanodine Receptor Calcium Release Channel', 'Sarcoplasmic Reticulum'] | 9,644,234 | [['B01.050'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['H01.158.344.528', 'H01.158.782.236'], ['E05.481'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['A10.690.552.500.500.600', 'A11.620.249.400'], ['A10.690.552.500.500.700', 'A11.620.249.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Keratinocyte growth factor causes proliferation of urothelium in vivo. | PURPOSE: To determine the effect of keratinocyte growth factor (KGF), a mesenchymally derived epithelial growth factor that can cause proliferation of pulmonary, gastrointestinal and mammary epithelia, on urothelium.MATERIALS AND METHODS: Recombinant human KGF was systemically administered to rats and Rhesus monkeys, a... | ['Animals', 'Cell Division', 'Epithelial Cells', 'Female', 'Fibroblast Growth Factor 10', 'Fibroblast Growth Factor 7', 'Fibroblast Growth Factors', 'Growth Substances', 'Kidney', 'Macaca mulatta', 'Male', 'Proliferating Cell Nuclear Antigen', 'RNA, Messenger', 'Rats', 'Rats, Inbred Lew', 'Rats, Sprague-Dawley', 'Recep... | 7,658,592 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.436'], ['D12.644.276.624.200', 'D12.776.467.624.200', 'D23.529.624.200'], ['D12.644.276.624.170', 'D12.776.467.624.170', 'D23.529.624.170'], ['D12.644.276.624', 'D12.776.467.624', 'D23.529.624'], ['D27.505.696.377'], ['A05.810... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
LipidBlast templates as flexible tools for creating new in-silico tandem mass spectral libraries. | Tandem mass spectral libraries (MS/MS) are usually built by acquiring experimentally measured mass spectra from chemical reference compounds. We here show the versatility of in-silico or computer generated tandem mass spectra that are directly obtained from compound structures. We use the freely available LipidBlast de... | ['Combinatorial Chemistry Techniques', 'Computer Simulation', 'Glycolipids', 'High-Throughput Screening Assays', 'Molecular Structure', 'Molecular Weight', 'Reference Standards', 'Software', 'Tandem Mass Spectrometry'] | 25,340,521 | [['E05.197.312', 'J01.897.836.249.249'], ['L01.224.160'], ['D09.400.410', 'D10.390'], ['E05.916.680'], ['G02.111.570', 'G02.466'], ['G02.494'], ['E05.978.808'], ['L01.224.900'], ['E05.196.566.880']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Early and late results of surgical correction of pulmonary artery sling. | Since 1976, we have operated on 4 children with pulmonary vascular sling. They were 5, 12, 19, and 54 months old. All patients were seen initially with severe stridor. Diagnosis was made by barium swallow in all 4. Each child was operated on through a left thoracotomy; the left pulmonary artery was dissected deep betwe... | ['Child, Preschool', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Infant, Newborn', 'Infant, Newborn, Diseases', 'Male', 'Methods', 'Pulmonary Artery', 'Replantation', 'Time Factors', 'Tracheal Diseases', 'Ventilation-Perfusion Ratio'] | 485,624 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Consistency in the amount of linear polymerization shrinkage in syringe-type composites. | OBJECTIVES: The purpose of this study was to investigate whether the composite resin in a syringe showed a consistent shrinkage through its content. Additionally, the amount of linear shrinkage was compared between materials.METHODS: Five brands of syringe-type and one brand of carpule-type composite resins were used i... | ['Analysis of Variance', 'Composite Resins', 'Materials Testing', 'Pharmaceutical Vehicles', 'Polymers', 'Syringes'] | 10,863,446 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['E05.570'], ['D26.650.700', 'D27.720.744.770', 'E02.319.300.754'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['E07.877']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Interstitial lung disease (ILD) and severe ITP. | INTRODUCTION: Platelets play an important role in inflammatory and immune responses. We report interstitial lung disease (ILD) developing during the acute phase of severe thrombocytopenia in 3 patients with severe refractory ITP.METHODS AND RESULTS: We identified 3 cases with severe ITP who developed ILD in the course ... | ['Aged', 'Biopsy', 'Blood Platelets', 'Chronic Disease', 'Danazol', 'Diagnosis, Differential', 'Disease Progression', 'Female', 'Humans', 'Immunoglobulins, Intravenous', 'Inflammation', 'Lung Diseases, Interstitial', 'Male', 'Middle Aged', 'Pneumonia', 'Pulmonary Fibrosis', 'Purpura, Thrombocytopenic, Idiopathic', 'Rad... | 17,364,997 | [['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['A11.118.188', 'A15.145.229.188'], ['C23.550.291.500'], ['D04.210.500.745.432.235'], ['E01.171'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Mitigation of heat stress-related complications by a yeast fermentate product. | Heat stress results in a multitude of biological and physiological responses which can become lethal if not properly managed. It has been shown that heat stress causes significant adverse effects in both human and animals. Different approaches have been proposed to mitigate the adverse effects caused by heat stress, am... | ['Animals', 'Body Temperature', 'Dietary Supplements', 'Erythrocytes', 'Fermentation', 'Heat Stress Disorders', 'Heat-Shock Response', 'Humans', 'Intestines', 'Lipopolysaccharides', 'Male', 'Probiotics', 'Rats', 'Rats, Sprague-Dawley', 'Saccharomyces cerevisiae'] | 27,503,713 | [['B01.050'], ['E01.370.600.875.374', 'G07.110'], ['G07.203.300.456', 'J02.500.456'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G02.111.158.249', 'G03.191.249'], ['C26.522'], ['G07.775.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Laminaria use in midtrimester abortions induced by intra-amniotic prostaglandin F2alpha with urea and intravenous oxytocin. | A laminaria tent was used as an adjunct during midtrimester abortion to attempt to shorten the injection-abortion interval without adversely affecting the frequency of infection, hemorrhage, failed abortion, or cervical laceration. Eighty patients, between 14 and 20 weeks' gestation and desiring pregnancy termination, ... | ['Abortifacient Agents', 'Abortion, Induced', 'Adolescent', 'Adult', 'Amnion', 'Female', 'Humans', 'Oxytocin', 'Pregnancy', 'Pregnancy Trimester, Second', 'Prostaglandins F', 'Seaweed', 'Time Factors', 'Urea'] | 453,259 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination of arsenic in air particulates and diesel exhaust particulates by spectrophotometry. | A method was developed for the determination of trace arsenic by spectrophotometry. The proposed method is rapid, simple, and inexpensive. This method can be used for sensitive determination of trace arsenic in environmental samples and especially in air particulates. The results obtained by this method as a proposed m... | ['Air Pollutants', 'Arsenic', 'Cities', 'Environmental Monitoring', 'Iran', 'Spectrophotometry', 'Vehicle Emissions'] | 15,900,780 | [['D27.888.284.101'], ['D01.268.513.249'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['N06.850.460.350.080', 'N06.850.780.375'], ['Z01.252.245.500.350'], ['E05.196.712.726', 'E05.196.867.826'], ['D20.832']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Late-onset and young-onset relapsing-remitting multiple sclerosis: evidence from a retrospective long-term follow-up study. | BACKGROUND AND PURPOSE: Late-onset multiple sclerosis (MS) has a prevalence of about 10-20% in natural history MS studies. Few data have been published about the long-term disease trajectory in the cohort of late-onset relapsing-remitting MS (LORRMS). The aim of this study was to identify the risk factors for reaching ... | ['Adolescent', 'Adult', 'Age of Onset', 'Brain', 'Disability Evaluation', 'Disease Progression', 'Female', 'Follow-Up Studies', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Multiple Sclerosis, Relapsing-Remitting', 'Retrospective Studies', 'Risk Factors', 'Young Adult'] | 29,956,427 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['A08.186.211'], ['E01.370.400'], ['C23.550.291.656'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630... | ['Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Neurotoxic effects of methylene chloride: are they long lasting in humans? | The neurotoxicity of methylene chloride (MC) is of special interest because of its acute effects on the central nervous system (CNS) and its metabolic conversion to carbon monoxide. A cohort study of retired airline mechanics was conducted to examine the hypothesis that long term exposure to MC results in lasting effec... | ['Aged', 'Attention', 'Brain', 'Color Perception', 'Humans', 'Memory, Short-Term', 'Methylene Chloride', 'Motor Activity', 'Muscles', 'Occupational Exposure', 'Reaction Time', 'Smell', 'Space Perception'] | 2,064,980 | [['M01.060.116.100'], ['F02.830.104.214'], ['A08.186.211'], ['F02.463.593.932.217'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.407'], ['D02.455.526.439.642'], ['F01.145.632', 'G11.427.410.698'], ['A02.633', 'A10.690'], ['N06.850.460.350.600'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Modification of the immobilized metal affinity electrophoresis using sodium dodecyl sulfate polyacrylamide gel electrophoresis. | Modification to the original immobilized metal affinity electrophoresis (IMAEP) technique is presented. SDS-PAGE is used instead of native PAGE for improved extraction of phosphoproteins from a mixture of proteins. Protein samples treated with 2% w/v SDS instead of native sample buffer ensure that proteins are negative... | ['Aluminum', 'Amino Acid Sequence', 'Animals', 'Caseins', 'Electrophoresis, Polyacrylamide Gel', 'Humans', 'Iron', 'Manganese', 'Metals', 'Molecular Sequence Data', 'Ovalbumin', 'Phosphopeptides', 'Phosphoproteins', 'Serum Albumin', 'Sodium Dodecyl Sulfate', 'Titanium'] | 18,633,940 | [['D01.268.557.050', 'D01.552.547.050'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D01.268.556.484', 'D01.2... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Intracranial hemorrhagic lesions: evaluation with spin-echo and gradient-refocused MR imaging at 0.5 and 1.5 T. | Twenty patients with intracranial hemorrhage were examined with magnetic resonance (MR) imaging at 0.5 and 1.5 T within 2 hours on the two imagers for lesions less than 30 days old and within 24 hours for lesions older than 30 days. MR studies included T1- and T2-weighted spin-echo (SE) and T2*-weighted gradient-refocu... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Brain', 'Cerebral Hemorrhage', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Time Factors'] | 2,740,502 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A08.186.211'], ['C10.228.140.300.535.200', 'C14.907.253.573.200', 'C23.550.414.913.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['G01.910.857']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Balancing selection on MHC class I in wild brown trout Salmo trutta. | Evidence is reported for balancing selection acting on variation at major histocompatibility complex (MHC) in wild populations of brown trout Salmo trutta. First, variation at an MHC class I (satr-uba)-linked microsatellite locus (mhc1) is retained in small S. trutta populations isolated above waterfalls although varia... | ['Animals', 'Genes, MHC Class I', 'Genetic Variation', 'Genetics, Population', 'Microsatellite Repeats', 'Selection, Genetic', 'Trout'] | 22,957,875 | [['B01.050'], ['G05.360.340.024.340.610.595', 'G05.360.340.024.380.500.595', 'G12.500.500.595'], ['G05.365'], ['H01.158.273.343.335'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['G05.783'], ['B01.050.150.900.493.817.750.825']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Three-dimensional histomorphometry of the normal and early glaucomatous monkey optic nerve head: neural canal and subarachnoid space architecture. | PURPOSE: To delineate three dimensionally the neural canal landmarks-Bruch's membrane opening (BMO), anterior sclera canal opening (ASCO), anterior laminar insertion (ALI), posterior laminar insertion (PLI), and posterior scleral canal opening (PSCO)-and the anterior-most aspect of the subarachnoid space (ASAS), within... | ['Animals', 'Bruch Membrane', 'Glaucoma', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Macaca fascicularis', 'Male', 'Neural Pathways', 'Optic Disk', 'Optic Nerve Diseases', 'Subarachnoid Space'] | 17,591,889 | [['B01.050'], ['A09.371.894.223.250', 'A10.272.220.250', 'A10.615.179.250'], ['C11.525.381'], ['L01.224.308'], ['E01.370.350.400', 'L01.224.308.410'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['A08.612'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['C10.292.700', 'C11.640'], ['A08.186.566.166.686']... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Giant cell fibroblastoma of the vulva at the site of a previous fibroepithelial stromal polyp: a case report. | BACKGROUND: Giant cell fibroblastoma (GCF) is an unusual soft tissue tumor, occurring predominantly in infants and children, and rarely in adults. Giant cell fibroblastoma develops de novo in the dermis or subcutis with a predilection for the extremities, the abdominal and chest walls, umbilical and inguinal regions.CA... | ['Adult', 'Dermatofibrosarcoma', 'Diagnosis, Differential', 'Female', 'Giant Cell Tumors', 'Humans', 'Neoplasms, Fibroepithelial', 'Neoplasms, Second Primary', 'Polyps', 'Stromal Cells', 'Vulvar Neoplasms'] | 17,415,117 | [['M01.060.116'], ['C04.557.450.565.590.350.320', 'C04.557.450.795.350.320'], ['E01.171'], ['C04.557.450.565.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.565.590.595', 'C04.557.470.625'], ['C04.692'], ['C23.300.825'], ['A11.329.830'], ['C04.588.945.418.968', 'C13.351.500.944.819', 'C13.351.937.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A case of primary papillary disseminated adenocarcinoma of canine lung. | Primary lung tumors are rare in dogs, whereas pulmonary metastatic neoplastic involvement is common. We describe a case of a 12-year-old male, mixed-breed dog with a 3-month history of coughing and dyspnea. The investigating protocol, which also includes transcutaneous pulmonary biopsy, allowed a diagnosis of lung aden... | ['Adenocarcinoma, Papillary', 'Animals', 'Dog Diseases', 'Dogs', 'Lung Neoplasms', 'Male'] | 20,461,460 | [['C04.557.470.200.025.085'], ['B01.050'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520']] | ['Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Accuracy of halothane vaporizers with respect to temperature, carrier gas composition and gas flow rate]. | Since the precise measurement of halothane-concentration in the patients gas support during routine anesthesia still requires much effort, the accuracy of the vaporizers halothane output remains important for the safety of anesthesia and the education of younger anesthesiologists. In the present study 30 halothane vapo... | ['Anesthesia', 'Anesthesiology', 'Halothane', 'Humans', 'Mass Spectrometry', 'Oxygen', 'Temperature', 'Time Factors'] | 4,073,446 | [['E03.155'], ['H02.403.066'], ['D02.455.526.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.566'], ['D01.268.185.550', 'D01.362.670'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Oligomycin A induces autophagy in the IPLB-LdFB insect cell line. | Functional and morphological modifications in the IPLB-LdFB insect cell line were examined following a short treatment with a reversible inhibitor of mitochondrial ATP synthase, oligomycin A, and subsequent incubation for various times in oligomycin-A-free medium. Oncosis, apoptosis and autophagy at variable percentage... | ['Animals', 'Anti-Bacterial Agents', 'Autophagy', 'Cell Line', 'Cell Survival', 'Insecta', 'Oligomycins'] | 16,767,407 | [['B01.050'], ['D27.505.954.122.085'], ['G04.011'], ['A11.251.210'], ['G04.346'], ['B01.050.500.131.617'], ['D02.540.505.620']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Does the respiratory distress syndrome in twins and singletons run different risks of persistent ductus arteriosus? | The incidence and evolution of patent ductus arteriosus (PDA) was evaluated in twins and preterm singletons with birth weight less than or equal to 1750 g admitted to our Department in 1987 for respiratory distress syndrome (RDS). Screening by echocardiography and Doppler-flow studies (AT MK 600) was performed on the t... | ['Diseases in Twins', 'Ductus Arteriosus, Patent', 'Echocardiography', 'Humans', 'Indomethacin', 'Infant, Low Birth Weight', 'Infant, Newborn', 'Infant, Premature, Diseases', 'Neonatal Screening', 'Respiratory Distress Syndrome, Newborn', 'Ultrasonography'] | 2,698,575 | [['C23.550.291.750'], ['C14.240.400.340', 'C14.280.400.340', 'C16.131.240.400.340'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473.420'], ['M01.060.703.520.460'], ['M01.060.703.520'], ['C16.614.521'], ['E01.370.225.910', 'E01.37... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
High-performance liquid chromatographic study of codeine, norcodeine, and morphine as indicators of codeine ingestion. | A simple quantitative method for determining codeine, norcodeine, and morphine in urine by high-performance liquid chromatography (HPLC) is described. Urine samples are hydrolyzed and extracted through differential pH extraction. The subsequent use of HPLC allowed separation and quantitation on a reverse phase system w... | ['Chromatography, High Pressure Liquid', 'Codeine', 'Glucuronidase', 'Humans', 'Hydrolysis', 'Morphine', 'Radioimmunoassay', 'Substance-Related Disorders', 'Time Factors'] | 6,716,978 | [['E05.196.181.400.300'], ['D03.132.577.249.562.149', 'D03.605.497.607.204', 'D03.633.400.686.607.204', 'D04.615.723.795.576.149'], ['D08.811.277.450.426'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.380'], ['D03.132.577.249.562.571', 'D03.605.497.607.587', 'D03.633.400.686.607.587', 'D04.615.723.795.576.57... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spatial distribution and ecological risk assessment of phthalic acid esters and phenols in surface sediment from urban rivers in Northeast China. | Concentration and spatial distribution of six phthalic acid esters (PAEs) and eight phenols in sediments of urban rivers, namely the Xi River (XR) and Pu River (PR) in Shenyang city, Northeast China were investigated and the ecological risk of these target pollutants was assessed based on the risk quotient (RQ) approac... | ['Animals', 'China', 'Cities', 'Daphnia', 'Environmental Monitoring', 'Esters', 'Fishes', 'Geologic Sediments', 'Phenols', 'Phthalic Acids', 'Plants', 'Risk Assessment', 'Rivers', 'Water Pollutants, Chemical'] | 27,209,337 | [['B01.050'], ['Z01.252.474.164'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['B01.050.500.131.365.150.200'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D02.241.400'], ['B01.050.150.900.493'], ['G01.311.330', 'G16.500.320'], ['D02.455.426.559.389.657'], ['D02.241.223.805'], ['B01.650'], ['E05.318.740.600.800.71... | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[The DASH questionnaire. French translation of a trans-cultural adaptation]. | The DASH (Disability of Arm-Shoulder-Hand) is a self-administered questionnaire developed in 1994 by representatives of the Institute for Work & Health (IWH) and the American Academy of Orthopaedic Surgeons (AAOS). It measures the physical disability and symptoms for all upper limb disorders in a heterogeneous populati... | ['Arm Injuries', 'Cultural Characteristics', 'Disabled Persons', 'Elbow', 'Humans', 'Language', 'Orthopedics', 'Semantics', 'Shoulder Joint', 'Surveys and Questionnaires'] | 11,582,907 | [['C26.088'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['M01.150'], ['A01.378.800.420'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['H02.403.810.494'], ['L01.559.598.745'], ['A02.835.583.748'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
A method for linking computed image features to histological semantics in neuropathology. | In medical image analysis the image content is often represented by features computed from the pixel matrix in order to support the development of improved clinical diagnosis systems. These features need to be interpreted and understood at a clinical level of understanding Many features are of abstract nature, as for i... | ['Algorithms', 'Artificial Intelligence', 'Brain Neoplasms', 'Humans', 'Image Interpretation, Computer-Assisted', 'Meningioma', 'Pattern Recognition, Automated', 'Reproducibility of Results', 'Semantics', 'Sensitivity and Specificity', 'Subtraction Technique'] | 17,698,418 | [['G17.035', 'L01.224.050'], ['G17.035.250', 'L01.224.050.375'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['C04.557.580.520', 'C04.557.645.520', 'C04.588.614.250.580.500', 'C10.551.2... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Escherichia coli survival in groundwater and effluent measured using a combination of propidium iodide and the green fluorescent protein. | AIMS: The aim of this study was to deterimine the survival of an enteric bacterium in anaerobic groundwater and effluent microcosms using the green fluorescent protein (GFP) marker gene in combination with the viability indicator propidium iodide (PI).METHODS AND RESULTS: The pEGFP vector (Clontech) was transformed int... | ['Anaerobiosis', 'Escherichia coli', 'Green Fluorescent Proteins', 'Indicators and Reagents', 'Luminescent Proteins', 'Plasmids', 'Propidium', 'Water Microbiology', 'Water Supply'] | 12,067,376 | [['G02.111.062', 'G03.078'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.532.265'], ['D27.720.470.410'], ['D12.776.532'], ['G05.360.600'], ['D03.633.300.633.700'], ['H01.158.273.540.274.777', 'N06.850.425.450'], ['J01.293.821.500']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Effects of response preparation on developmental improvements in inhibitory control. | Studies in adults indicate that response preparation is crucial to inhibitory control, but it remains unclear whether preparation contributes to improvements in inhibitory control over the course of childhood and adolescence. In order to assess the role of response preparation in developmental improvements in inhibitor... | ['Adolescent', 'Adolescent Development', 'Adult', 'Age Factors', 'Chi-Square Distribution', 'Child', 'Child Development', 'Cognition', 'Female', 'Humans', 'Inhibition, Psychological', 'Male', 'Reaction Time', 'Regression Analysis', 'Saccades'] | 20,347,061 | [['M01.060.057'], ['F01.525.049', 'G07.345.374.500'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['F02.463.188'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. | Mammary epithelial cells constitutively expressing Id-1 protein are unable to differentiate, acquire the ability to proliferate, and invade the extracellular matrix. In addition, Id-1 is aberrantly over-expressed in aggressive and metastatic breast cancer cells, as well as in human breast tumor biopsies from infiltrati... | ['Animals', 'Blotting, Northern', 'Blotting, Western', 'Breast Neoplasms', 'Cell Line, Tumor', 'Disease Progression', 'Down-Regulation', 'Extracellular Matrix', 'Genetic Therapy', 'Genetic Vectors', 'Humans', 'Immunohistochemistry', 'Inhibitor of Differentiation Protein 1', 'Lung Neoplasms', 'Matrix Metalloproteinase 1... | 14,578,451 | [['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['C23.550.291.656'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds. | Multitargeting compounds comprising activity on more than a single biological target have gained remarkable relevance in drug discovery owing to the complexity of multifactorial diseases such as cancer, inflammation, or the metabolic syndrome. Polypharmacological drug profiles can produce additive or synergistic effect... | ['Animals', 'Chemistry, Pharmaceutical', 'Crystallography, X-Ray', 'Drug Design', 'Humans', 'Ligands', 'Machine Learning', 'Metabolic Networks and Pathways', 'Models, Animal', 'Structure-Activity Relationship'] | 30,035,545 | [['B01.050'], ['H01.158.703.007', 'H01.181.466'], ['E05.196.309.742.225'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.480'], ['G17.035.250.500', 'L01.224.050.375.530'], ['G03.493'], ['E05.598'], ['G02.111.830', 'G07.690.773.997']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
A simple framework for assessing technical skills in a resident observed structured clinical examination (OSCE): vaginal laceration repair. | OBJECTIVES: Educators of trainees in procedure-based specialties need focused assessment tools that are valid, objective, and assess technical skills in a realistic context. A framework for hybrid assessment using standardized patient scenarios and bench skills testing might facilitate evaluation of competency.METHODS:... | ['Clinical Competence', 'Delivery, Obstetric', 'Educational Measurement', 'Episiotomy', 'Female', 'Gynecology', 'Humans', 'Lacerations', 'Manikins', 'Obstetrics', 'Vagina'] | 23,337,664 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E04.520.252'], ['I02.399'], ['E04.520.252.750'], ['H02.403.763.750', 'H02.403.810.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.540'], ['J01.897.280.500.545.129.400', 'L01.178.820.090.545.129.400'], ['H02.403.810.450'], ['A05.360.319.779']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 |
Exosomes from EV71-infected oral epithelial cells can transfer miR-30a to promote EV71 infection. | OBJECTIVE: As an extracellular vesicle, exosomes can release from virus-infected cells containing various viral or host cellular elements and could stimulate recipient's cellular response. Enterovirus 71 (EV71), a single-strand positive-sense RNA virus, is known to cause hand, foot, and mouth disease (HFMD) in children... | ['Cells, Cultured', 'Enterovirus A, Human', 'Epithelial Cells', 'Exosomes', 'Gene Knockout Techniques', 'Humans', 'Interferon Type I', 'Macrophages', 'MicroRNAs', 'Myeloid Differentiation Factor 88', 'RNA-Seq'] | 31,958,204 | [['A11.251'], ['B04.820.578.750.284.180'], ['A11.436'], ['A11.284.295.588.750', 'A11.284.430.214.190.875.190.880.495'], ['E05.393.335.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890', 'D12.776.467.374.440.890', 'D23.529.374.440.890'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Are model parameters linked to processing stages? An empirical investigation for the ex-Gaussian, ex-Wald, and EZ diffusion models. | In previous research, the parameters of the ex-Gaussian distribution have been subject to a wide variety of interpretations. The present study investigated whether the ex-Gaussian model is capable of distinguishing effects on separate processing stages (i.e., pre-motor vs. motor). In order to do so, we used datasets wh... | ['Data Analysis', 'Humans', 'Models, Psychological', 'Normal Distribution', 'Reaction Time'] | 30,949,790 | [['H01.548.338'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.695'], ['E05.318.740.994.500', 'G17.820.500', 'N05.715.360.750.750.565', 'N06.850.520.830.994.500'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677']] | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Antigen-specific early primary humoral responses modulate immunodominance of B cell epitopes. | Accumulation of primary Abs against two distinct epitopes on a designed polypeptide, MEP-1, was examined. The early primary response was predominantly against a C-terminal epitope (MEP 77-100), although subsequent maturation established an epitope within the N-terminal half (MEP 17-31) as the immunodominant one. Invers... | ['Amino Acid Sequence', 'Animals', 'Antibody Formation', 'B-Lymphocytes', 'Base Sequence', 'DNA Primers', 'Epitopes', 'Female', 'Hepatitis B Antibodies', 'Hepatitis B Antigens', 'Immunoglobulin G', 'Lymphocyte Activation', 'Lymphocyte Cooperation', 'Mice', 'Mice, Inbred Strains', 'Molecular Sequence Data', 'Recombinant... | 7,519,207 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G12.450.050.370.250'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Regulation of mitochondrial dynamics and distribution by synapse position and neuronal activity in the axon. | Proper distribution of axonal mitochondria is critical for multiple neuronal functions. To understand the underlying mechanisms for population behavior, quantitative characterisation of elemental dynamics on multiple time scales is required. Here we investigated the stability and transport of axonal mitochondria using ... | ['Animals', 'Axons', 'Cells, Cultured', 'Mice', 'Mitochondria', 'Mitochondrial Dynamics', 'Pyramidal Cells', 'Synapses'] | 23,725,294 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A11.251'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['G04.599.750'], ['A08.675.790', 'A11.671.790'], ['A08.850', 'A11.284.149.165.420.780']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular imaging using hyperpolarized 13C. | MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this modality has limited the clinical use to imaging of water protons. With hyperpolarization techniques, the signal from a given number of nuclear spins can be raised more than 100 000 times. The strong signal enhancement enables imagi... | ['Animals', 'Carbon Isotopes', 'Humans', 'Lung Diseases', 'Magnetic Resonance Imaging', 'Male', 'Models, Chemical', 'Rabbits', 'Thermodynamics'] | 15,572,334 | [['B01.050'], ['D01.268.150.075', 'D01.496.123'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['E01.370.350.825.500'], ['E05.599.495'], ['B01.050.150.900.649.313.968.700'], ['G01.906']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Poor survival but high immunogenicity of IL-2-expressing Salmonella typhimurium in inherently resistant mice. | An IL-2-expressing, attenuated strain of Salmonella typhimurium (strain GIDIL2) was previously shown to survive poorly and to have lower immunogenicity in susceptible mice than its parental, non-cytokine-expressing strain (designated BRD509). In the present study, we compared the immune responses induced by both bacter... | ['Animals', 'Colony Count, Microbial', 'Immunity, Innate', 'Immunization', 'Immunologic Memory', 'Interleukin-2', 'Mice', 'Mice, Inbred C3H', 'Peritoneum', 'Salmonella Infections, Animal', 'Salmonella typhimurium', 'Spleen'] | 15,050,962 | [['B01.050'], ['E01.370.225.875.220', 'E05.200.875.220'], ['G12.450.564'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.680.310'], ['G12.450.050.500'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D12.776.467.374.480.372', 'D23.5... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Epidermoid tumor arising in the anterior interhemispheric fissure. | There have only been 18 cases reported in the literature of an epidermoid tumor arising in the interhemispheric fissure. We report a 45-year-old woman with an epidermoid tumor arising in the interhemispheric fissure. She presented with a focal convulsive seizure. Radiological imaging identified a tumor in the interhemi... | ['Brain Neoplasms', 'Carcinoma, Squamous Cell', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Middle Aged', 'Neurosurgical Procedures', 'Seizures', 'Tomography, X-Ray Computed'] | 16,431,109 | [['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E04.525'], ['C10.597.742', 'C23.888.592.742'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain. | We investigated whether in utero exposure to the Gram(-) bacteriotoxin lipopolysaccharide (LPS) induces dopamine (DA) neuron loss in rats. The proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) kills DA neurons and is elevated in the brains of patients with Parkinson's disease (PD). LPS is a potent induce... | ['Animals', 'Animals, Newborn', 'Corpus Striatum', 'Dopamine', 'Endotoxins', 'Female', 'Fetal Diseases', 'Gestational Age', 'Immunohistochemistry', 'Interleukin-1', 'Mesencephalon', 'Parkinson Disease', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Rats', 'Rats, Sprague-Dawley', 'Risk Factors', 'Tumor Necrosis Fac... | 11,835,448 | [['B01.050'], ['B01.050.050.282'], ['A08.186.211.200.885.287.249.487'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D23.946.123.329'], ['C13.703.277', 'C16.300'], ['G07.345.500.325.235.968', 'G08.686.320'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
In Vitro Model of Coronary Angiogenesis. | Here, we describe an in vitro culture assay to study coronary angiogenesis. Coronary vessels feed the heart muscle and are of clinical importance. Defects in these vessels represent severe health risks such as in atherosclerosis, which can lead to myocardial infarctions and heart failures in patients. Consequently, cor... | ['Animals', 'COUP Transcription Factor II', 'Cellular Reprogramming', 'Coronary Vessels', 'Dissection', 'Embryo, Mammalian', 'Extracellular Matrix', 'Female', 'Heart', 'Heart Ventricles', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Mice', 'Models, Biological', 'Neovascularization, Physiologic', 'Pregnancy... | 32,225,157 | [['B01.050'], ['D12.776.260.643.039.500', 'D12.776.260.703.200', 'D12.776.826.209.039.500', 'D12.776.930.780.750'], ['G04.152.262', 'G05.135'], ['A07.015.114.269', 'A07.015.908.194'], ['E01.370.225.998.221', 'E04.221', 'E05.200.998.221'], ['A16.254'], ['A11.284.295.310'], ['A07.541'], ['A07.541.560'], ['B01.050.150.900... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
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