Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Characterization of the murine cytomegalovirus 38 kDa m137 gene product. | Murine cytomegalovirus (MCMV) m137 null mutants, Deltam137A and Deltam137B, were generated by inserting a gpt cassette into a deleted region of the open reading frame. A polyclonal antiserum produced to an Escherichia coli expressed gst-m137 fusion protein was used to show that a 38 kDa polypeptide corresponding to the... | ['3T3 Cells', 'Animals', 'Herpesviridae Infections', 'Mice', 'Mice, SCID', 'Muromegalovirus', 'Mutagenesis', 'Viral Plaque Assay', 'Viral Proteins', 'Virus Replication'] | 11,900,850 | [['A11.251.210.100', 'A11.329.228.100'], ['B01.050'], ['C01.925.256.466'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.780'], ['B04.280.382.150.500'], ['G05.558'], ['E01.370.225.875.970.790', 'E05.200.875.970.790'], ['D12.776.964'], ['G06.920.925']] | ['Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Pharmacoproteomic approach by quantitative targeted proteomics]. | Omics analyses provided many candidates for drug targets and biomarkers. However, these analyses have not contributed to drug development efficiently because of top-down omics analyses. To solve this problem, we have recently developed quantitative targeted proteomics with multiplexed-multiple reaction monitoring (mult... | ['Amino Acid Sequence', 'Animals', 'Drug Design', 'Drug Discovery', 'Humans', 'Molecular Targeted Therapy', 'Peptides', 'Precision Medicine', 'Proteomics', 'Species Specificity'] | 22,465,926 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.574'], ['D12.644'], ['E02.782', 'H02.403.200.700'], ['H01.158.201.843', 'H01.158.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Susceptibility of microbial cells to the modified PIP2 | BACKGROUND: Magnetic nanoparticles (MNPs) are characterized by unique physicochemical and biological properties that allow their employment as highly biocompatible drug carriers. Gelsolin (GSN) is a multifunctional actin-binding protein involved in cytoskeleton remodeling and free circulating actin sequestering. It was... | ['Anti-Bacterial Agents', 'Antifungal Agents', 'Biofilms', 'Candida', 'Cell Membrane', 'Gelsolin', 'Gold', 'Magnetite Nanoparticles', 'Methicillin-Resistant Staphylococcus aureus', 'Microbial Sensitivity Tests', 'Nanoshells', 'Peptide Fragments', 'Plankton', 'Pseudomonas aeruginosa', 'Rhodamines'] | 31,286,976 | [['D27.505.954.122.085'], ['D27.505.954.122.136'], ['A20.593', 'G06.120'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['A11.284.149'], ['D05.750.078.730.350', 'D12.644.360.372.437', 'D12.776.157.125.412.437', 'D12.776.220.525.350', 'D12.776.476.387.437'], ['D01.268.556.322', 'D01.268.956.186', 'D01.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The questionable utility of mandatory screening for the human immunodeficiency virus. | Trauma patients have been identified as a high-risk group for human immunodeficiency virus (HIV) infection, particularly those patients with penetrating injuries from urban violence. We prospectively evaluated more than 2,000 trauma patients for HIV infection at our ACS-certified trauma center and report the results. B... | ['AIDS Serodiagnosis', 'Cost-Benefit Analysis', 'Diagnostic Tests, Routine', 'Female', 'HIV Infections', 'Humans', 'Kansas', 'Male', 'Prospective Studies', 'Risk', 'Wounds and Injuries'] | 8,273,848 | [['E01.370.225.812.735.060', 'E01.370.225.875.408.500', 'E05.200.812.735.060', 'E05.200.875.408.500', 'E05.478.594.760.060'], ['N03.219.151.125'], ['E01.370.395'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.40... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Remodelling of Ca2+ handling organelles in adult rat ventricular myocytes during long term culture. | It is well known that for cardiomyocytes, isolation and culturing induce largely unknown remodelling processes. We analysed changes in the structure of cell compartments with optical techniques such as confocal microscopy and fluorescence redistribution after photobleaching employing adenoviral-mediated transduction of... | ['Animals', 'Calcium', 'Cell Culture Techniques', 'Cell Membrane Permeability', 'Endoplasmic Reticulum', 'Heart Ventricles', 'Microscopy, Confocal', 'Mitochondria, Heart', 'Myocytes, Cardiac', 'Organelles', 'Rats'] | 20,540,947 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G03.143.335', 'G04.175'], ['A11.284.430.214.190.875.248'], ['A07.541.560'], ['E01.370.350.515.395', 'E05.595.395'], ['A11.284.430.214.190.875.564.627.603', 'A11.284.835.62... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy of 4-methylpyrazole for treatment of ethylene glycol intoxication in dogs. | 4-Methylpyrazole (4-MP), an alcohol dehydrogenase inhibitor, was administered to dogs to treat ethylene glycol (EG) intoxication. Eleven dogs were given 10.6 g of EG/kg of body weight; 5 dogs were treated with 4-MP 5 hours after EG ingestion and 6 dogs were treated with 4-MP 8 hours after EG ingestion. 4-Methylpyrazole... | ['Animals', 'Dog Diseases', 'Dogs', 'Ethylene Glycol', 'Ethylene Glycols', 'Female', 'Fomepizole', 'Male', 'Pyrazoles', 'Time Factors'] | 7,887,524 | [['B01.050'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['D02.033.455.250.268'], ['D02.033.455.250'], ['D03.383.129.539.344'], ['D03.383.129.539'], ['G01.910.857']] | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Establishment of an indocyanine green test using an automatic chemistry analyzer. | The indocyanine green (ICG) clearance test has been used to assess the reserve of hepatic function. This method is based on the spectrometric measurement of its plasma concentration at maximum wavelength of 805 nm, which requires a spectrophotometer and associated maintenance. We established an ICG clearance test using... | ['Autoanalysis', 'Chemistry, Clinical', 'Coloring Agents', 'Humans', 'Indocyanine Green', 'Liver Function Tests', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Spectrophotometry'] | 16,475,907 | [['E05.059'], ['H01.181.341'], ['D27.720.233'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473.400'], ['E01.370.372.460'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Eculizumab effect on the hemostatic state in patients with paroxysmal nocturnal hemoglobinuria. | Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by a hypercoagulable state associated with acute hemolysis. Eculizumab is used to reduce the intensity of intravascular hemolysis in PNH patients. The hemostatic status of three patients with PNH was assessed during eculizumab treatment by D-dimer assay and the... | ['Adult', 'Antibodies, Monoclonal, Humanized', 'Blood Coagulation Tests', 'Drug Monitoring', 'Female', 'Fibrin Fibrinogen Degradation Products', 'Hemoglobinuria, Paroxysmal', 'Hemolysis', 'Hemostatics', 'Humans', 'L-Lactate Dehydrogenase', 'Male', 'Thrombelastography'] | 25,497,169 | [['M01.060.116'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['E01.370.225.625.115', 'E05.200.625.115'], ['E01.370.520.200'], ['D12.776.124.270.300', 'D12.776.811.300.290'], ['C15.378.071.141.560', 'C15.378.190.625.460'], ['C23.550.403', 'G12.122.545'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Crystallization and preliminary X-ray analysis of the CRP-cAMP-DNA (full length) complex. | The Escherichia coli cyclic AMP receptor protein (CRP) is a well known transcription activator protein. In this study, CRP was overexpressed, purified and cocrystallized with cAMP and a 38 bp full-length double-stranded DNA fragment. The full-length segment differed from the half-site fragments used in previous crystal... | ['Crystallization', 'Crystallography, X-Ray', 'Cyclic AMP Receptor Protein', 'Escherichia coli', 'Escherichia coli Proteins'] | 23,695,578 | [['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D12.776.930.165'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Positron Emission Tomography/Computed Tomography in Esophageal Carcinoma: Applications and Limitations. | Squamous cell carcinoma and adenocarcinoma represent approximately 98% of esophageal malignant tumors. During the last 30 years, the incidence of adenocarcinoma has increased in Western countries (including the USA) where adenocarcinoma currently represents more than 60% of esophageal malignancies, although, worldwide,... | ['Esophageal Neoplasms', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Positron Emission Tomography Computed Tomography'] | 29,179,897 | [['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.655', 'C23.550.727.655'], ['E01.370.350.350.800.700.500', 'E01.370.350.350.810.645', 'E01.370.350.567.500', 'E01.370.350.600.350.700.810.4... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD. | Genome-wide association studies identified single nucleotide polymorphisms (SNPs) in the nicotinic acetylcholine receptors (nAChRs) cluster as a risk factor for nicotine dependency and COPD. We investigated whether SNPs in the nAChR cluster are associated with smoking habits and lung function decline, and if these pote... | ['Adult', 'Cohort Studies', 'Female', 'Forced Expiratory Volume', 'Genetic Predisposition to Disease', 'Genetic Variation', 'Genome-Wide Association Study', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Multigene Family', 'Netherlands', 'Polymorphism, Single Nucleotide', 'Pulmonary Disease, Chronic Obstruct... | 22,438,921 | [['M01.060.116'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.386.700.660.230', 'G09.772.650.430'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.365'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[An Experience Providing Hospice Care to a Terminal Cancer Patient]. | This study discusses a case in which corneal-donation care was provided to a 57-year-old patient with terminal salivary gland cancer. Nursing care was provided from June 1 to June 28, 2017. The overall nursing assessment (covering physiological, psychological, social, and spiritual aspects) confirmed that the three mai... | ['Hospice and Palliative Care Nursing', 'Humans', 'Middle Aged', 'Neoplasms', 'Nurse-Patient Relations', 'Terminal Care', 'Tissue and Organ Procurement'] | 30,276,778 | [['H02.478.676.350', 'N02.421.533.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['F01.829.401.650.600', 'N05.300.660.560'], ['E02.760.905', 'N02.421.585.905'], ['N02.421.911']] | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Parallel instabilities of long-term potentiation, place cells, and learning caused by decreased protein kinase A activity. | To further elucidate the links among synaptic plasticity, hippocampal place cells, and spatial memory, place cells were recorded from wild-type mice and transgenic "R(AB)" mice with reduced forebrain protein kinase A (PKA) activity after introduction into a novel environment. Place cells in both strains were similar du... | ['Action Potentials', 'Animals', 'Appetitive Behavior', 'Cyclic AMP-Dependent Protein Kinases', 'Electrodes, Implanted', 'Hippocampus', 'Learning', 'Long-Term Potentiation', 'Memory', 'Mice', 'Neuronal Plasticity', 'Pyramidal Cells', 'Space Perception', 'Spatial Behavior'] | 11,050,131 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['F01.145.113.111'], ['D08.811.913.696.620.682.700.150.125', 'D12.644.360.200.125', 'D12.776.476.200.125'], ['E07.305.250.319', 'E07.695.202'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['F02.463.425', 'F02.784.629.529'], ['G11.561.6... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Robust smoothness estimation in statistical parametric maps using standardized residuals from the general linear model. | The assessment of significant activations in functional imaging using voxel-based methods often relies on results derived from the theory of Gaussian random fields. These results solve the multiple comparison problem and assume that the spatial correlation or smoothness of the data is known or can be estimated. End res... | ['Brain', 'Brain Mapping', 'Computer Simulation', 'Humans', 'Linear Models', 'Magnetic Resonance Imaging', 'Models, Neurological'] | 10,600,421 | [['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.8... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The 5-HT₆ serotonin receptor antagonist SB-271046 attenuates the development and expression of nicotine-induced locomotor sensitisation in Wistar rats. | 5-HT(6) receptors are almost exclusively expressed in the central nervous system, particularly in areas relevant for addictive behaviour. Based on this, together with other data, this receptor may be a viable target for the control of drug abuse. The present study tested the ability of the 5-HT(6) receptor antagonist S... | ['Animals', 'Behavior, Animal', 'Dose-Response Relationship, Drug', 'Male', 'Motor Activity', 'Nicotine', 'Rats', 'Rats, Wistar', 'Receptors, Serotonin', 'Secondary Prevention', 'Serotonin Antagonists', 'Substance Withdrawal Syndrome', 'Substance-Related Disorders', 'Sulfonamides', 'Thiophenes', 'Time Factors'] | 21,329,711 | [['B01.050'], ['F01.145.113'], ['G07.690.773.875', 'G07.690.936.500'], ['F01.145.632', 'G11.427.410.698'], ['D03.132.760.570', 'D03.383.725.518'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D12.776.543.750.670.800', 'D12.776.543.750.695.800', 'D12.776.543.750.720.850... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Pattern of injuries among children and adolescents in Riyadh, Saudi Arabia: a household survey. | OBJECTIVES: To determine the incidence and pattern of injuries among children and adolescents <18 years old in Riyadh city and to identify associated factors.MATERIAL AND METHODS: A cross sectional household survey included children and adolescents <18 years. A two-stage cluster sample was used to recruit the participa... | ['Accidental Falls', 'Accidents, Traffic', 'Adolescent', 'Child', 'Child, Preschool', 'Cross-Sectional Studies', 'Female', 'Foodborne Diseases', 'Humans', 'Male', 'Risk Factors', 'Saudi Arabia', 'Sex Distribution', 'Surveys and Questionnaires', 'Wounds and Injuries'] | 20,724,436 | [['N06.850.135.122'], ['N06.850.135.392'], ['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C25.723.415'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.7... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. | Because betel quid chewing has been linked to the development of oral cancer, pathobiological effects of an aqueous areca nut extract, four areca nut alkaloids (arecoline, guvacoline, guvacine, and arecaidine), and four nitrosated derivatives [N-nitrosoguvacoline, N-nitrosoguvacine, 3-(N-nitrosomethylamino)propionaldeh... | ['Arecoline', 'Colony-Forming Units Assay', 'DNA Damage', 'Epithelium', 'Humans', 'Mouth Mucosa', 'Nitroso Compounds'] | 2,766,297 | [['D03.066.515.292', 'D03.132.080', 'D03.383.725.547.292'], ['E01.370.225.500.383', 'E05.200.500.383', 'E05.242.383'], ['G05.200'], ['A10.272'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.615.550.599', 'A14.549.512'], ['D02.654']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Training simulation for helicopter navigation by characterizing visual scan patterns. | INTRODUCTION: Helicopter overland navigation is a cognitively complex task that requires continuous monitoring of system and environment parameters and years of training. This study investigated potential improvements to training simulation by analyzing the influences of flight expertise on visual scan patterns.METHODS... | ['Adult', 'Aerospace Medicine', 'Aircraft', 'Cognition', 'Decision Making', 'Humans', 'Male', 'Orientation', 'Professional Competence', 'Task Performance and Analysis', 'Vision, Ocular'] | 21,888,270 | [['M01.060.116'], ['H02.403.029'], ['J01.937.285.100'], ['F02.463.188'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.058.577', 'F02.830.606'], ['I02.399.630'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600'], ['F02.830.816.964', 'G02.111.820.480.900', 'G04.835.480.900', 'G11.561.79... | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 |
Adenosine triphosphate-induced oxygen radical production and CD11b up-regulation: Ca(++) mobilization and actin reorganization in human eosinophils. | Eosinophils are major effector cells in cellular inflammatory conditions such as parasitic infections, atopic diseases, bullous dermatoses, and vasculitis. Biological activities of adenosine triphosphate (ATP) were characterized in human eosinophils and compared with those of other eosinophil activators such as complem... | ['Actin Cytoskeleton', 'Actins', 'Adenosine Triphosphate', 'Calcium Signaling', 'Chemokine CCL11', 'Chemokines, CC', 'Complement C5a', 'Cytokines', 'Egtazic Acid', 'Eosinophils', 'Flow Cytometry', 'Free Radicals', 'Fura-2', 'Humans', 'Inflammation', 'Macrophage-1 Antigen', 'Pertussis Toxin', 'Platelet Activating Factor... | 10,648,411 | [['A11.284.430.214.190.750.050'], ['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['D12.644.276.374.200.110.550', 'D12.776.467.374.200.110.550', 'D23.125.3... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Study monitoring: a useful tool for quality health research]. | As well as protecting the rights of participants, a study's ethics must encompass the quality of its execution. As such, international standards have been established for studies involving human subjects. The objective of this review is to evaluate the usefulness of the Guide to Good Clinical Practice and "study monito... | ['Biomedical Research', 'Health', 'Humans', 'Quality Control'] | 19,695,138 | [['H01.770.644.145'], ['N01.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.608']] | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Clinical characteristics and treatment of patients with IgA nephropathy and hepatitis B surface antigen. | BACKGROUND: The aim of this study is to investigate the clinical characteristics and our experience of treating patients with IgA nephropathy (IgAN) and IgA nephropathy with hepatitis B surface antigen (HBs-IgAN).METHODS: From 1996 to 2011, biopsy-proven IgAN was diagnosed in 477 patients and 22 (4.6%) had hepatitis B ... | ['Adult', 'Antiviral Agents', 'DNA, Viral', 'Female', 'Glomerular Filtration Rate', 'Glomerulonephritis, IGA', 'Guanine', 'Hepatitis B', 'Hepatitis B Surface Antigens', 'Humans', 'Male', 'Middle Aged'] | 23,506,536 | [['M01.060.116'], ['D27.505.954.122.388'], ['D13.444.308.568'], ['E01.370.390.400.300', 'G08.852.357'], ['C12.777.419.570.363.608', 'C13.351.968.419.570.363.608', 'C20.111.525'], ['D03.633.100.759.758.399.454'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D23.050.327.495.500.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Activity-dependent variations in conduction velocity of C fibers of rat sciatic nerve. | Changes in the conduction velocity and subsequent conduction block were characterized following impulse activity in single C fibers of rat sciatic nerves. C fibers which had the same resting conduction velocities often exhibited quite different profiles of the activity-dependent latency change and/or conduction block f... | ['Animals', 'Electrophysiology', 'Male', 'Nerve Fibers', 'Neural Conduction', 'Rats', 'Reaction Time', 'Sciatic Nerve'] | 8,090,372 | [['B01.050'], ['H01.158.344.528', 'H01.158.782.236'], ['A08.675.542', 'A11.671.501'], ['G07.265.753', 'G11.561.601'], ['B01.050.150.900.649.313.992.635.505.700'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['A08.800.800.720.450.760']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Renal dysplasia combined with ureter duplex and vesica duplex (author's transl)]. | A case of a 29-year-old man with left renal dysplasia, ureter duplex and vesica duplex is presented. Clinical aspects, therapy and pathogenesis are discussed. | ['Adult', 'Humans', 'Kidney', 'Male', 'Ureter', 'Urinary Bladder', 'Urogenital System'] | 7,404,899 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['A05.810.776'], ['A05.810.890'], ['A05']] | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
MTOC formation during mitotic exit in fission yeast. | Microtubules polymerise from nucleation templates containing gamma tubulin. These templates are generally concentrated in discrete structures called microtubule organising centres (MTOCs). In Schizosaccharomyces pombe, an equatorial MTOC (EMTOC) forms mid-way through anaphase B and then disassembles during the final st... | ['Actins', 'Anaphase', 'Anaphase-Promoting Complex-Cyclosome', 'Cell Cycle', 'Drosophila Proteins', 'Immune Sera', 'Ligases', 'Microscopy, Confocal', 'Microtubule-Organizing Center', 'Microtubules', 'Mitosis', 'Protein-Serine-Threonine Kinases', 'Schizosaccharomyces', 'Spindle Apparatus', 'Tubulin', 'Ubiquitin-Protein ... | 11,792,817 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['G04.144.220.220.687.222', 'G04.144.220.220.781.050', 'G05.113.220.687.250', 'G05.113.220.781.050'], ['D08.811.464.938.750.092', 'D12.776.167.024'], ['G04.144'], ['D12.776.093.500.462'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis and evaluation of novel macrocyclic antifungal peptides. | Echinocandins are a novel class of macrocyclic antifungal peptides that act by inhibiting the â-(1,3)-D-glucan synthase complex, which is not present in mammalian cells. Due to the large number of hydroxyl groups present in these complex macrocyclic lipopeptides, most structure-activity relationship studies have relied... | ['Antifungal Agents', 'Candida albicans', 'Echinocandins', 'Enzyme Inhibitors', 'Glucosyltransferases', 'Magnetic Resonance Spectroscopy', 'Microbial Sensitivity Tests', 'Molecular Structure', 'Solid-Phase Synthesis Techniques', 'Spectrometry, Mass, Electrospray Ionization'] | 21,940,175 | [['D27.505.954.122.136'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['D12.644.641.311'], ['D27.505.519.389'], ['D08.811.913.400.450.460'], ['E05.196.867.519'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['G02.111.570', 'G02.466'], ['E05.197.500', 'J01.897.836.249.500... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Is attachment transmitted across generations? The plot thickens. | Studies have demonstrated a strong relation between adult attachment security, using the Adult Attachment Interview (AAI), and infant security, using the Strange Situation Procedure (SSP). This suggests that a mother's representations of attachment may influence the development of her infant's attachment to her. This s... | ['Adult', 'Child Abuse', 'Child of Impaired Parents', 'Defense Mechanisms', 'Depressive Disorder', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Maternal Behavior', 'Models, Psychological', 'Mother-Child Relations', 'Object Attachment', 'Parenting', 'Personality Assessment', 'Personality Development', 'Pers... | 20,603,421 | [['M01.060.116'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['M01.106'], ['F01.393'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['F01.829.263.370.215'], ['E05.599.695'], ['F01.829.263.370.290.170'], ['F02.739.794.624'], ['F01.829.263.370.310'],... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Do grossly identifiable ganglia lie along the spinal accessory nerve? A gross and histologic study with potential neurosurgical significance. | OBJECTIVE: To elucidate further the anatomy of focal enlargements that have been observed along the spinal accessory nerve (SAN) as it courses within the posterior cranial fossa.METHODS: Dissection of the posterior cranial fossa was performed on 27 adult cadavers with attention to the SAN and any focal enlargements ass... | ['Accessory Nerve', 'Adult', 'Aged', 'Cadaver', 'Cranial Fossa, Posterior', 'Female', 'Foramen Magnum', 'Functional Laterality', 'Ganglia, Spinal', 'Humans', 'Male', 'Meninges', 'Middle Aged', 'Neurosurgical Procedures', 'Tissue Fixation'] | 22,120,387 | [['A08.800.800.120.060'], ['M01.060.116'], ['M01.060.116.100'], ['C23.550.260.224'], ['A01.456.830.200', 'A02.835.232.781.750.400'], ['A02.835.232.781.572.434'], ['F02.830.297.425', 'G11.561.225.425'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inhibition of salivary amylase by black and green teas and their effects on the intraoral hydrolysis of starch. | Tea decoctions prepared from a number of black and green teas inhibited amylase in human saliva. Black teas gave higher levels of inhibition than green teas, and removal of tea tannins with gelatin led to the loss of inhibitory activity from all decoctions. Streptococcal amylase was similarly inhibited by tea decoction... | ['Adult', 'Amylases', 'Carbohydrate Metabolism', 'Carbohydrates', 'Cariostatic Agents', 'Enzyme Inhibitors', 'Female', 'Fermentation', 'Fluorides', 'Humans', 'Hydrolysis', 'Male', 'Maltose', 'Middle Aged', 'Mouth', 'Saliva', 'Salivary Proteins and Peptides', 'Starch', 'Streptococcus mutans', 'Tannins', 'Tea'] | 9,577,990 | [['M01.060.116'], ['D08.811.277.450.066'], ['G02.111.158', 'G03.191'], ['D09'], ['D25.223', 'D27.505.696.706.222', 'D27.720.102.223', 'D27.720.799.113', 'J01.637.051.223'], ['D27.505.519.389'], ['G02.111.158.249', 'G03.191.249'], ['D01.248.497.158.380', 'D01.303.350.300'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
What makes a leader? | Superb leaders have very different ways of directing a team, a division, or a company. Some are subdued and analytical; others are charismatic and go with their gut. And different situations call for different types of leadership. Most mergers need a sensitive negotiator at the helm, whereas many turnarounds require a ... | ['Emotions', 'Health Facility Administrators', 'Humans', 'Intelligence', 'Leadership', 'Motivation', 'Professional Competence', 'United States'] | 10,187,249 | [['F01.470'], ['M01.526.070.490', 'M01.526.485.430', 'N02.360.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.543'], ['F01.752.609'], ['F01.658', 'F01.752.543.500.750'], ['I02.399.630'], ['Z01.107.567.875']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Helicobacter hepaticus NikR controls urease and hydrogenase activities via the NikABDE and HH0418 putative nickel import proteins. | Helicobacter hepaticus open reading frame HH0352 was identified as a nickel-responsive regulator NikR. The gene was disrupted by insertion of an erythromycin resistance cassette. The H. hepaticus nikR mutant had five- to sixfold higher urease activity and at least twofold greater hydrogenase activity than the wild-type... | ['Amino Acid Sequence', 'Base Sequence', 'DNA, Bacterial', 'Electrophoretic Mobility Shift Assay', 'Gene Expression Profiling', 'Gene Expression Regulation, Bacterial', 'Gene Knockout Techniques', 'Helicobacter hepaticus', 'Hydrogenase', 'Membrane Transport Proteins', 'Molecular Sequence Data', 'Mutagenesis, Insertiona... | 23,139,401 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.212'], ['E05.196.401.500'], ['E05.393.332'], ['G05.308.300'], ['E05.393.335.750'], ['B03.440.500.362', 'B03.660.150.235.500.250.410'], ['D08.811.682.400'], ['D12.776.157.530', 'D12.776.543.585'], ['L01.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Clinical and psychological characteristics of the initial cohort of the Dominantly Inherited Alzheimer Network (DIAN). | OBJECTIVE: The purpose was to describe clinical, cognitive, and personality characteristics at baseline assessment of 249 participants, 19 to 60 years of age, in a multinational longitudinal study of autosomal dominant Alzheimer's disease (ADAD).METHOD: Participants (74% cognitively normal) were from ADAD families with... | ['Adult', 'Alzheimer Disease', 'Family Health', 'Female', 'Genes, Dominant', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Mutation', 'Neuropsychological Tests', 'Young Adult'] | 24,219,606 | [['M01.060.116'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['N01.400.300'], ['G05.360.340.024.340.240', 'G05.420.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['M01.060.116.630'], ['G05.365.590'], ... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Composite chromophobe renal cell carcinoma with sarcomatoid differentiation containing osteosarcoma, chondrosarcoma, squamous metaplasia and associated collecting duct carcinoma: a case report. | BACKGROUND: Chromophobe renal cell carcinoma (ChRCC) is a morphologically distinct renal cell carcinoma type which may rarely show composite morphology.CASE: A 61-year-old man presented with a composite ChRCC with sarcomatoid transformation containing osteosarcomatous, chondrosarcomatous and squamous metaplastic differ... | ['Carcinoma, Renal Cell', 'Chondrosarcoma', 'Humans', 'Male', 'Middle Aged', 'Osteosarcoma'] | 25,291,862 | [['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['C04.557.450.565.280', 'C04.557.450.795.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.450.565.575.650', 'C04.557.450.795.... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The Co-Occurrence and Unique Mental Health Effects of Political Violence and Intimate Partner Violence. | The global mental health ramifications of political violence and intimate partner violence (IPV) are well established. There also exists a growing body of evidence about the increased risks for IPV within situations of political violence. Yet, except for a few studies, there is little literature that simultaneously exa... | ['Adult', 'Arabs', 'Depression', 'Exposure to Violence', 'Female', 'Humans', 'Intimate Partner Violence', 'Mental Health', 'Politics', 'Risk Factors', 'Stress Disorders, Post-Traumatic', 'Surveys and Questionnaires', 'Violence', 'Young Adult'] | 26,400,490 | [['M01.060.116'], ['M01.686.754.167'], ['F01.145.126.350'], ['I01.880.735.900.869'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.198.240.856.575', 'I01.880.735.900.688'], ['F02.418', 'N01.400.500'], ['I01.738'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.62... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Size, number and chemical composition of nanosized particles in drinking water determined by analytical microscopy and LIBD. | In this paper we comprehensively characterized particles in drinking water originating from a lake water source. We focused on particles smaller than a few hundred nm. Several analytical techniques were applied to obtain information on number concentration, size distribution, morphology and chemical composition of the ... | ['Lasers', 'Microscopy', 'Microscopy, Atomic Force', 'Microscopy, Electron, Transmission', 'Nanoparticles', 'Particle Size', 'Ultrafiltration', 'Water Purification', 'Water Supply'] | 18,348,895 | [['E07.632.490', 'E07.710.520'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['E01.370.350.515.402.580', 'E05.595.402.580'], ['J01.637.512.600'], ['G02.712'], ['E04.292.975', 'E05.196.454.807', 'G01.280.807', 'G02.263.807'], ['N06.850.780.200.800.800.900.900', 'N06... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
[Non-operative treatment of ureteral calculi using ureterorenoscopy]. | Rigid transurethral ureteroscopy was used in the treatment of 31 patients with 32 ureteral calculi. The stones could be visualized in 90% of cases. The aim of treatment was immediate extraction under visual control for smaller calculi and retrograde advancement into the renal pelvis with subsequent extracorporeal shock... | ['Catheterization', 'Endoscopes', 'Endoscopy', 'Female', 'Humans', 'Male', 'Pressure', 'Risk', 'Ureter', 'Ureteral Calculi'] | 6,489,900 | [['E02.148', 'E05.157'], ['E07.230.220', 'E07.858.240'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.715'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700', 'N06.850.520.830.600.800'], ['A05.810.776'], ['C12.777.725.938.500', 'C12.777.967.374.500', 'C1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Photobiomodulation with 630 plus 810 nm wavelengths induce more in vitro cell viability of human adipose stem cells than human bone marrow-derived stem cells. | The goal of the current experiment is to explore the influence of combined and/or single applications of red and near infrared (NIR) photobiomodulation (PBM) at different wavelengths, energy densities and times on cell viability, population doubling time (PDT), and apoptosis of in vitro cultures of human bone marrow-de... | ['Adipose Tissue', 'Apoptosis', 'Bone Marrow Cells', 'Cell Survival', 'Cells, Cultured', 'Humans', 'Lasers, Gas', 'Low-Level Light Therapy', 'Mesenchymal Stem Cells', 'Stem Cells'] | 31,710,923 | [['A10.165.114'], ['G04.146.954.035'], ['A11.148', 'A15.378.316'], ['G04.346'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.632.490.367', 'E07.710.520.367'], ['E02.594.540', 'E02.774.500'], ['A11.329.830.500', 'A11.872.590.500'], ['A11.872']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of ovarian cyst formation in women using the levonorgestrel-releasing intrauterine system vs. hysterectomy. | OBJECTIVE: To analyze the effect of the levonorgestrel-releasing intrauterine system (LNG-IUS) on ovarian cyst formation, endometrial thickness and the size of uterus and uterine fibroids by ultrasonography.SUBJECTS AND METHODS: This was a prospective, randomized trial comparing the LNG-IUS and hysterectomy in 236 wome... | ['Adult', 'Female', 'Humans', 'Hysterectomy', 'Leiomyoma', 'Levonorgestrel', 'Menorrhagia', 'Middle Aged', 'Ovarian Cysts', 'Ovary', 'Progesterone Congeners', 'Prospective Studies', 'Ultrasonography', 'Uterine Neoplasms', 'Uterus', 'Vagina'] | 12,383,322 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['C04.557.450.590.450'], ['D04.210.500.668.651.693.762.450'], ['C13.351.500.852.691.449', 'C23.550.414.993.350', 'C23.550.568.875'], ['M01.060.116.630'], ['C04.182.612', 'C13.351.500.056.630.580', 'C19.391.630.580'], ['A05.360.319.1... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Improved retroviral vectors for gene transfer and expression. | We describe a set of murine retrovirus-based vectors that include unique cloning sites for insertion of cDNAs such that the cDNA can be driven by either the retroviral long terminal repeat, the immediate early promoter of human cytomegalovirus, or the simian virus 40 early promoter. The vectors carry the neomycin phosp... | ['Animals', 'Biotechnology', 'Cell Line', 'Gene Expression Regulation, Viral', 'Genetic Markers', 'Genetic Vectors', 'Helper Viruses', 'Retroviridae', 'Transfection', 'Viral Proteins', 'Virus Replication'] | 2,631,796 | [['B01.050'], ['H01.158.550', 'J01.897.120'], ['A11.251.210'], ['G05.308.385'], ['D23.101.387', 'G05.695.450'], ['G05.360.337'], ['B04.423'], ['B04.613.807', 'B04.820.650'], ['E05.393.350.810', 'G05.728.860'], ['D12.776.964'], ['G06.920.925']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model. | BACKGROUND: Bone resorption preceding bone formation has been reported following the administration of recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered in an absorbable collagen sponge (ACS) in metaphyseal bone. This study characterizes treatment with rhBMP-2/ACS in metaphyseal bone with use of a nonh... | ['Animals', 'Bone Density', 'Bone Morphogenetic Protein 2', 'Bone Morphogenetic Proteins', 'Bone Resorption', 'Femur Neck', 'Gelatin Sponge, Absorbable', 'Macaca fascicularis', 'Male', 'Osteogenesis', 'Recombinant Proteins', 'Time Factors', 'Tomography, X-Ray Computed', 'Transforming Growth Factor beta'] | 20,124,069 | [['B01.050'], ['G11.427.100'], ['D12.644.276.954.200.200', 'D12.776.467.942.200.200', 'D23.529.942.200.200'], ['D12.644.276.954.200', 'D12.776.467.942.200', 'D23.529.942.200'], ['C05.116.264', 'G11.427.213.150'], ['A02.835.232.043.150.510'], ['E07.858.740.300'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The amyotrophic lateral sclerosis (ALS) patient perspective on misdiagnosis and its repercussions. | We studied the rate of initial "misdiagnosis', along with factors than might distinguish such patients, in 64 patients with amyotrophic lateral sclerosis (ALS) who completed a survey of 34 questions. Announcement of the survey was made by electronic newsletter and users group bulletin board directed at ALS patients. Th... | ['Adult', 'Aged', 'Amyotrophic Lateral Sclerosis', 'Community Health Services', 'Computer Communication Networks', 'Data Collection', 'Diagnostic Errors', 'Female', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Patient Acceptance of Health Care', 'Surveys and Questionnaires'] | 8,899,669 | [['M01.060.116'], ['M01.060.116.100'], ['C10.228.854.139', 'C10.574.562.250', 'C10.574.950.050', 'C10.668.467.250', 'C18.452.845.800.050'], ['N02.421.143'], ['L01.224.230.110'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['E01.354', 'N02.421.450.280'], ['E02.760.400', 'N02.421.585.400'], ['B0... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Effects of the uterus and mid-pregnancy conceptus on luteal lifespan of the rat. | Hysterectomy on or after Day 10 resulted in a quick return of pseudopregnant rats to oestrus but the interval to oestrus in pregnant rats was significantly longer (P less than 0.01), indicating that the gravid uterine horn interfered with uterine-induced luteolysis by Day 10. When pseudopregnant rats were injected with... | ['Animals', 'Corpus Luteum', 'Estrus', 'Female', 'Fetus', 'Hysterectomy', 'Placental Lactogen', 'Pregnancy', 'Progesterone', 'Pseudopregnancy', 'Rats', 'Rats, Inbred Strains', 'Tissue Extracts', 'Uterus'] | 7,054,498 | [['B01.050'], ['A05.360.319.114.630.278', 'A06.300.312.497.278'], ['G08.686.195.500'], ['A16.378'], ['E04.950.300.399'], ['D06.472.699.649.692', 'D12.644.548.726.692', 'D12.776.780.650'], ['G08.686.784.769'], ['D04.210.500.745.745.654.829', 'D06.472.334.734.623', 'D06.472.334.851.687.750'], ['G08.686.784.769.887'], ['B... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High ambient pressure of 41 bar increases the cerebral toxicity of penicillins. | Sodium benzylpenicillin, cloxacillin, and azlocillin were infused intravenously in awake rats at 1 and 41 bar until they convulsed. The doses necessary to elicit convulsions were significantly lower at 41 than at 1 bar, i.e., with a 24% (P less than 0.0005) lower dose of benzylpenicillin and a 23% lower dose of azlocil... | ['Amino Acids', 'Animals', 'Atmospheric Pressure', 'Azlocillin', 'Brain', 'Cloxacillin', 'Hippocampus', 'Male', 'Penicillin G', 'Penicillins', 'Rats', 'Rats, Inbred Strains', 'Seizures'] | 3,363,754 | [['D12.125'], ['B01.050'], ['G16.500.750.274', 'N06.230.300.100.185'], ['D02.065.589.099.750.750.050.075', 'D02.886.108.750.750.050.075', 'D03.633.100.300.750.750.050.075'], ['A08.186.211'], ['D02.065.589.099.750.625.150', 'D02.886.108.750.625.150', 'D03.633.100.300.750.625.150'], ['A08.186.211.180.405', 'A08.186.211.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Chlamydia pneumoniae in a free-ranging giant barred frog (Mixophyes iteratus) from Australia. | The koala biovar of Chlamydia pneumoniae was identified in lung tissue from a sick, free-ranging giant barred frog (Mixophyes iteratus) by using electron microscopy, C. pneumoniae-specific fluorescent-antibody staining, cell culture, and sequencing of the ompA, ompB and 16S rRNA genes. This is the first report of a chl... | ['Animals', 'Anura', 'Bacterial Outer Membrane Proteins', 'Chlamydia Infections', 'Chlamydophila pneumoniae', 'Genes, Bacterial', 'Lung', 'Lung Diseases', 'Male', 'Molecular Sequence Data', 'RNA, Ribosomal, 16S'] | 10,364,623 | [['B01.050'], ['B01.050.150.900.090.180'], ['D12.776.097.120', 'D12.776.543.100'], ['C01.150.252.400.210.125', 'C01.150.252.734.301', 'C01.221.812.281.301', 'C01.778.281.301', 'C12.294.668.281.301', 'C13.351.500.711.281.301'], ['B03.440.190.190.230.249'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Enhanced beetle luciferase for high-resolution bioluminescence imaging. | We developed an enhanced green-emitting luciferase (ELuc) to be used as a bioluminescence imaging (BLI) probe. ELuc exhibits a light signal in mammalian cells that is over 10-fold stronger than that of the firefly luciferase (FLuc), which is the most widely used luciferase reporter gene. We showed that ELuc produces a ... | ['Animals', 'Coleoptera', 'Diagnostic Imaging', 'Humans', 'Karyopherins', 'Luciferases', 'Luminescent Measurements', 'Luminescent Proteins', 'Molecular Probe Techniques', 'Molecular Probes', 'Protein Transport', 'Proteins'] | 20,368,807 | [['B01.050'], ['B01.050.500.131.617.720.500.500.375'], ['E01.370.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.750.500', 'D12.776.543.585.750.500', 'D12.776.660.502'], ['D08.811.682.517', 'D12.776.532.510'], ['E05.196.712.516'], ['D12.776.532'], ['E05.601'], ['D27.505.259.750', 'D27.720.470.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Reproducibility and accuracy in the morphometric and mechanical quantification of trabecular bone from 3 Tesla magnetic resonance images]. | OBJECTIVE: We used an animal model to analyze the reproducibility and accuracy of certain biomarkers of bone image quality in comparison to a gold standard of computed microtomography (ìCT).MATERIAL AND METHODS: We used magnetic resonance (MR) imaging and ìCT to study the metaphyses of 5 sheep tibiae. The MR images (3 ... | ['Animals', 'Bone and Bones', 'Magnetic Resonance Imaging', 'Reproducibility of Results', 'Sheep'] | 24,094,441 | [['B01.050'], ['A02.835.232', 'A10.165.265'], ['E01.370.350.825.500'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['B01.050.150.900.649.313.500.380.791']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Predicting severe acute pancreatitis in children based on serum lipase and calcium: A multicentre retrospective cohort study. | OBJECTIVE: This study aims to identify predictors of severe paediatric AP based on laboratory trends and peak/trough values on day 2 (D2) after presentation. The performance of identified predictors was first assessed and then combined with the previously validated sensitive predictor serum lipase ?7 times the upper li... | ['Adolescent', 'Calcium', 'Child', 'Child, Preschool', 'Cohort Studies', 'Female', 'Humans', 'Infant', 'Lipase', 'Male', 'Models, Statistical', 'Pancreatitis, Acute Necrotizing', 'Predictive Value of Tests', 'Retrospective Studies', 'Treatment Outcome'] | 27,161,174 | [['M01.060.057'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D08.811.277.352.100.400'], ['E05.318.740.500', 'E05.599.835', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparison of melatonin and oxytocin in the prevention of critical illness polyneuropathy in rats with experimentally induced sepsis. | BACKGROUND: Critical illness polyneuropathy is an acute neuromuscular disorder of critically ill patients and is characterized by limb and respiratory muscle weakness. The purpose of the study was to evaluate the neuroprotective effects of melatonin (MEL) and oxytocin (OT) on the early stage of sepsis by recording comp... | ['Animals', 'Antioxidants', 'Drug Evaluation, Preclinical', 'Electromyography', 'Lipid Peroxidation', 'Male', 'Malondialdehyde', 'Melatonin', 'Oxytocin', 'Polyneuropathies', 'Rats', 'Rats, Sprague-Dawley', 'Sepsis', 'Tumor Necrosis Factor-alpha'] | 23,312,812 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['E05.290.750', 'E05.337.550'], ['E01.370.405.255', 'E01.370.530.255'], ['G02.111.515', 'G03.295.531.587'], ['D02.047.700'], ['D03.633.100.473.914.481', 'D06.472.506'], ['D06.472.699.631.692.433', 'D12.644.548.691.692.433'], ['C10.668.829.800'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner. | Mechano-transduction is an emerging but still poorly understood component of T cell activation. Here we investigated the ligand-dependent contribution made by contractile actomyosin arcs populating the peripheral supramolecular activation cluster (pSMAC) region of the immunological synapse (IS) to T cell receptor (TCR)... | ['Actomyosin', 'Animals', 'Humans', 'Jurkat Cells', 'Ligands', 'Lymphocyte Activation', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Phosphorylation', 'Receptors, Antigen, T-Cell', 'T-Lymphocytes'] | 28,817,635 | [['D12.776.210.500.154'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.495', 'A11.251.860.180.495', 'A15.382.490.555.567.569.440'], ['D27.720.470.480'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['B01.050.150.900.649.313.992.635.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metabolic syndrome correlates poorly with cognitive performance in stroke-free community-dwelling older adults: a population-based, cross-sectional study in rural Ecuador. | BACKGROUND: Studies investigating a possible correlation between metabolic syndrome and cognitive decline have been inconsistent.AIMS: To determine whether metabolic syndrome or each of its components correlate with cognitive performance in community-dwelling older adults in rural Ecuador.METHODS: Stroke-free Atahualpa... | ['Aged', 'Cognition', 'Cognitive Dysfunction', 'Cross-Sectional Studies', 'Ecuador', 'Female', 'Humans', 'Independent Living', 'Male', 'Metabolic Syndrome', 'Middle Aged', 'Rural Population', 'Statistics as Topic', 'Surveys and Questionnaires', 'Triglycerides'] | 26,142,624 | [['M01.060.116.100'], ['F02.463.188'], ['F03.615.250.700'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['Z01.107.757.362'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.050.500', 'N01.224.791.550', 'N06.850.505.400.800.550'], ['C18.452.394.968.500.570', 'C18.452.625'], ['M0... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [... | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Interactions at the blood/material interface. | The complex interactions occurring at the blood/material interface of implanted blood-contacting biomaterials largely determine the clinical efficacy of small diameter vascular grafts. Physical characteristics of the material such as chemical composition, electrical charge, surface texture, elastic modulus, and porosit... | ['Adhesiveness', 'Adsorption', 'Blood Cells', 'Blood Physiological Phenomena', 'Blood Proteins', 'Blood Vessel Prosthesis', 'Endothelium, Vascular', 'Growth Substances', 'Humans', 'Hyperplasia', 'Materials Testing', 'Surface Properties', 'Thrombosis', 'Vascular Patency'] | 2,297,480 | [['G02.860.139'], ['G01.030', 'G02.020'], ['A11.118', 'A15.145.229'], ['G09.188'], ['D12.776.124'], ['E07.695.110'], ['A07.015.700.500', 'A10.272.491.355'], ['D27.505.696.377'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.444'], ['E05.570'], ['G02.860'], ['C14.907.355.830'], ['G09.330.920']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mice deficient in surfactant protein A (SP-A) and SP-D or in TLR2 manifest delayed parturition and decreased expression of inflammatory and contractile genes. | Previously we obtained compelling evidence that the fetus provides a critical signal for the initiation of term labor through developmental induction of surfactant protein (SP)-A expression by the fetal lung and secretion into amniotic fluid (AF). We proposed that interactions of AF macrophage (M?) Toll-like receptors ... | ['Amniotic Fluid', 'Animals', 'Cells, Cultured', 'Female', 'Flow Cytometry', 'Lung', 'Mice', 'Mice, Knockout', 'Myometrium', 'Parturition', 'Pregnancy', 'Pulmonary Surfactant-Associated Protein A', 'Pulmonary Surfactant-Associated Protein D', 'Real-Time Polymerase Chain Reaction', 'Toll-Like Receptor 2'] | 23,183,169 | [['A12.098', 'A16.378.149'], ['B01.050'], ['A11.251'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Estimating quantitative genetic parameters in haplodiploid organisms. | Haplodiploid organisms (diploid females and haploid males) are genetically distinct in that they have asymmetrical genetic segregation, gene dosage compensation in the haploid male, maternal effects, and a general propensity to inbreed. Taking these characteristics into account, we demonstrate how conventional experime... | ['Animals', 'Crosses, Genetic', 'Diploidy', 'Epistaxis', 'Female', 'Gene Dosage', 'Genomic Imprinting', 'Haploidy', 'Inbreeding', 'Male', 'Models, Genetic', 'Models, Statistical'] | 11,122,415 | [['B01.050'], ['E05.393.281'], ['G05.700.264'], ['C08.460.261', 'C09.603.261', 'C23.550.414.712', 'C23.888.852.040'], ['G05.380.350'], ['G05.308.203.500'], ['G05.700.456'], ['E05.820.150.520', 'G05.090.403'], ['E05.599.395.397'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Roles of chlorpropamide, alcohol and acetaldehyde in determining the chlorpropamide-alcohol flush. | The value and reproducibility of the chlorpropamide-alcohol flush (CPAF) have been questioned, and objective measures of the test are required. Recording of facial skin temperature, measurement of chlorpropamide, ethanol and acetaldehyde concentrations have been proposed for this purpose. The present study was designed... | ['Acetaldehyde', 'Adult', 'Alcohol Drinking', 'Chlorpropamide', 'Diabetes Mellitus, Type 2', 'Dose-Response Relationship, Drug', 'Drug Interactions', 'Ethanol', 'Female', 'Flushing', 'Humans', 'Male', 'Middle Aged', 'Placebos'] | 6,706,043 | [['D02.047.064'], ['M01.060.116'], ['F01.145.317.269'], ['D02.065.950.828.283', 'D02.886.590.795.283'], ['C18.452.394.750.149', 'C19.246.300'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.690.773.968'], ['D02.033.375'], ['C23.888.885.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D26.6... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Diterpenoids with inhibitory activity of nitrite production from Croton floribundus. | ETHNOPHARMACOLOGICAL RELEVANCE: Croton floribundus Spreng. (Euphorbiaceae), popularly known as Capixingu?, stands out due to its widespread use in traditional medicine to treat wounds, syphilis, hemorrhoids, eye diseases and as a purgative.AIM OF THE STUDY: To characterize clerodanes diterpenes from C. floribundus and ... | ['Animals', 'Cell Line', 'Circular Dichroism', 'Croton', 'Diterpenes', 'Diterpenes, Clerodane', 'Euphorbiaceae', 'Macrophages', 'Medicine, Traditional', 'Mice', 'Nitrites', 'RAW 264.7 Cells'] | 31,639,485 | [['B01.050'], ['A11.251.210'], ['E05.196.867.151'], ['B01.650.940.800.575.912.250.859.797.438.199'], ['D02.455.849.291'], ['D02.455.849.291.228'], ['B01.650.940.800.575.912.250.859.797.438'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['E02.190.488', 'I01.076.201.450.654'], ['B... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Chest X-ray evaluation training: impact of normal and abnormal image ratio and instructional sequence. | CONTEXT: Medical image perception training generally focuses on abnormalities, whereas normal images are more prevalent in medical practice. Furthermore, instructional sequences that let students practice prior to expert instruction (inductive) may lead to improved performance compared with methods that give students e... | ['Adult', 'Clinical Competence', 'Education, Medical, Undergraduate', 'Female', 'Humans', 'Learning', 'Male', 'Radiography, Thoracic', 'Radiology', 'Sensitivity and Specificity', 'Students, Medical', 'Teaching', 'Young Adult'] | 30,474,292 | [['M01.060.116'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.358.399.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['E01.370.350.700.730'], ['H02.403.740'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.85... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase. | The three-dimensional structures of Corynebacterium glutamicum diaminopimelate dehydrogenase as a binary complex with the substrate meso-diaminopimelate (meso-DAP) and a ternary complex with NADP+ and an isoxazoline inhibitor [Abbot, S.D., Lane-Bell, P., Kanwar, P.S.S., and Vederas, J. C. (1994) J. Am. Chem. Soc. 116, ... | ['Amino Acid Oxidoreductases', 'Binding Sites', 'Corynebacterium', 'Crystallography, X-Ray', 'Diaminopimelic Acid', 'Electrochemistry', 'Models, Molecular', 'NADP', 'Protein Conformation', 'Substrate Specificity'] | 9,521,647 | [['D08.811.682.664.500'], ['G02.111.570.120'], ['B03.510.024.250', 'B03.510.460.400.400.200'], ['E05.196.309.742.225'], ['D02.241.081.337.699.250', 'D12.125.095.390'], ['H01.181.529.307'], ['E05.599.595'], ['D03.633.100.759.646.138.749', 'D08.211.625', 'D13.695.667.138.749', 'D13.695.827.068.749'], ['G02.111.570.820.70... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination of microbial carbon sources and cycling during remediation of petroleum hydrocarbon impacted soil using natural abundance (14)C analysis of PLFA. | In a petroleum impacted land-farm soil in Sarnia, Ontario, compound-specific natural abundance radiocarbon analysis identified biodegradation by the soil microbial community as a major pathway for hydrocarbon removal in a novel remediation system. During remediation of contaminated soils by a plant growth promoting rhi... | ['Bacteria', 'Biodegradation, Environmental', 'Carbon', 'Carbon Dioxide', 'Carbon Isotopes', 'Environmental Monitoring', 'Fatty Acids', 'Gases', 'Hydrocarbons', 'Petroleum', 'Phospholipids', 'Soil Pollutants'] | 20,196,610 | [['B03'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['D01.268.150'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D01.268.150.075', 'D01.496.123'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D10.251'], ['D01.362'], ['D02.455'], ['D20.345.630', 'N06.230.132.258.630'], ['D10.570.755'], ['D27.888.284.756'... | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nine days post-thawing red cell conservation in a synthetic medium. Biochemical studies. | The expiration of thawed red cells (RBC) currently is 24 hours. This leads to problems in current transfusion practice, and often wastes rare and costly products. To remedy this situation, we developed a synthetic medium containing 0.085 g per l adenine, 5 g per l glucose, 48.0 g per l sucrose, 0.75 g per l NaH2PO4.H2O... | ['Adenosine Triphosphate', 'Blood Preservation', 'Blood Substitutes', 'Drug Storage', 'Erythrocyte Aging', 'Freezing', 'Humans', 'Hydrogen-Ion Concentration', 'Time Factors'] | 3,765,038 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['E02.792.833.230', 'E05.760.833.230'], ['D27.505.954.502.140', 'J01.637.087.249'], ['E05.916.350'], ['G04.043.260', 'G09.188.230'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Multiparametric discrimination of serous ovarian tumors by analytical morphometry. | In order to enhance the discrimination power in the field of serous ovarian tumors, we applied the software system SAM (Shape Analytical Morphometry) to the analytic studies of biological forms. Besides the usual dimensional evaluations (perimeter, area, maximum diameter and shape index), this procedure permits the des... | ['Cell Nucleus', 'Female', 'Humans', 'Multivariate Analysis', 'Ovarian Neoplasms'] | 1,511,716 | [['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Thyroid gland disorders in primary Sj?gren's syndrome. | OBJECTIVES: To evaluate the frequency of thyroid disorders in primary Sj?gen's syndrome.PATIENTS AND METHODS: 121 consecutive patients meeting Vitali's criteria for primary Sj?gren's syndrome and 74 with rheumatoid arthritis underwent thyroid hormone assays, tests for antimicrosomal and antithyroglobulin antibodies, te... | ['Adult', 'Aged', 'Aged, 80 and over', 'Arthritis, Rheumatoid', 'Autoantibodies', 'Chi-Square Distribution', 'Female', 'HLA-DR3 Antigen', 'Humans', 'Male', 'Middle Aged', 'Prevalence', 'Reference Values', 'Sex Distribution', "Sjogren's Syndrome", 'Thyroid Diseases', 'Thyroid Function Tests'] | 9,010,968 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Characterization of methanol-soluble and methanol-insoluble proteins from developing peanut seed. | The 85% methanol-soluble proteins are known to specifically contribute to the production of flavor of roasted peanut. To determine the nature of the 85% methanol-soluble proteins, they were isolated from the peanut seed, and the 85% methanol-soluble (MS) and 85% methanol-insoluble (MIS) fractions were characterized usi... | ['Amino Acids', 'Arachis', 'Carbohydrates', 'Electrophoresis, Capillary', 'Electrophoresis, Polyacrylamide Gel', 'Fatty Acids', 'Methanol', 'Plant Proteins', 'Seeds', 'Solubility'] | 11,087,512 | [['D12.125'], ['B01.650.940.800.575.912.250.401.077'], ['D09'], ['E05.196.401.190', 'E05.301.300.190'], ['E05.196.401.402', 'E05.301.300.319'], ['D10.251'], ['D02.033.623'], ['D12.776.765'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500.775'], ['G02.805']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia. | The clinical and prognostic relevance of many recently identified driver gene mutations in adult acute myeloid leukemia (AML) is poorly defined. We sequenced the coding regions or hotspot areas of 68 recurrently mutated genes in a cohort of 664 patients aged 18 to 86 years treated on 2 phase 3 trials of the German AML ... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Cytogenetic Analysis', 'DNA Mutational Analysis', 'Female', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Humans', 'Leukemia, Myeloid, Acute', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Mutation', 'Prognosis', 'Risk Factors', 'Survival... | 27,288,520 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.225.500.385', 'E05.200.500.385', 'E05.242.385', 'E05.393.285'], ['E05.393.760.700.300'], ['G05.330'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Impact of PrLZ overexpression on invasion of prostate cancer LNCaP cells in vitro]. | BACKGROUND AND OBJECTIVE: Prostate leucine zipper (PrLZ), a novel gene, is highly associated with the malignant progression of prostate cancer. We previously found that PrLZ overexpression can enhance the survival of prostate cancer LNCaP cells in vitro. This study was to investigate the impact of PrLZ on the invasion ... | ['Cell Line, Tumor', 'Cell Movement', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Male', 'Matrix Metalloproteinase 2', 'Neoplasm Invasiveness', 'Neoplasm Proteins', 'Prostatic Neoplasms', 'Transfection'] | 19,624,875 | [['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.656.300.480.205.352', 'D08.811.277.656.300.480.252.420', 'D08.811.277.656.300.480.525.700.150', 'D08.811.277.656.675.374.205.352', 'D08.811.277.656.675.374.252.420', '... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
astray, a zebrafish roundabout homolog required for retinal axon guidance. | As growing retinotectal axons navigate from the eye to the tectum, they sense guidance molecules distributed along the optic pathway. Mutations in the zebrafish astray gene severely disrupt retinal axon guidance, causing anterior-posterior pathfinding defects, excessive midline crossing, and defasciculation of the reti... | ['Alleles', 'Animals', 'Axons', 'Body Patterning', 'Chromosome Mapping', 'Crosses, Genetic', 'Eye', 'Female', 'Gene Expression Regulation, Developmental', 'Genes', 'In Situ Hybridization', 'Male', 'Mutation', 'Nerve Tissue Proteins', 'Phenotype', 'Receptors, Immunologic', 'Retina', 'Retinal Ganglion Cells', 'Superior C... | 11,313,496 | [['G05.360.340.024.340.030'], ['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['G07.345.500.100'], ['E05.393.183'], ['E05.393.281'], ['A01.456.505.420', 'A09.371'], ['G05.308.310'], ['G05.360.340.024.340'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.50... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subtypes of hepatitis B surface antigen in native-born and immigrant Israelis. | A survey of HBsAg among Jerusalem blood donors revealed a prevalence of 0.89% and a predominance of subtype ay (85%) compared with ad (15%). A simultaneous survey of patients with HBsAg-positive viral hepatitis revealed a similar predominance of ay (85%) compared with ad (15%). The uniform distribution of the dominant ... | ['Blood Donors', 'Carrier State', 'Hepatitis B Surface Antigens', 'Hepatitis, Viral, Human', 'Humans', 'Israel'] | 1,007,166 | [['M01.898.313'], ['N06.850.520.169'], ['D23.050.327.495.500.475'], ['C01.925.440', 'C06.552.380.705'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.375']] | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Cholesterol granuloma of a Haller cell associated with unilateral exophthalmos and diplopia. | Cholesterol granuloma is rare in the paranasal sinuses. We present what is to our knowledge the first case of cholesterol granuloma of a Haller cell associated with unilateral exophthalmos and diplopia in a 55-year-old man. | ['Cholesterol', 'Diplopia', 'Exophthalmos', 'Granuloma', 'Humans', 'Male', 'Maxillary Sinus', 'Middle Aged'] | 26,719,083 | [['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['C10.597.751.941.339', 'C11.966.339', 'C23.888.592.763.941.339'], ['C11.675.349'], ['C15.604.515.292', 'C23.550.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.531.621.578'], ['M01.060.116.630']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Helping older widows rebuild their lives. | Hospice support groups can help older widows rebuild their lives after losing their husbands. To establish new-normal patterns for their lives, grieving widows need to address these questions: (a) What parts do you want your family and friends to play in your new-normal life?; (b) How do you want to spend your time, no... | ['Adaptation, Psychological', 'Family', 'Female', 'Friends', 'Grief', 'Hospice Care', 'Humans', 'Self-Help Groups', 'Widowhood'] | 21,895,432 | [['F01.058'], ['F01.829.263', 'I01.880.853.150'], ['M01.252'], ['F01.470.142.110'], ['E02.760.905.400', 'N02.421.585.905.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.540.782'], ['F01.829.263.315.500.862', 'I01.240.361.500.862', 'I01.880.853.150.423.500.862', 'N01.224.361.500.862', 'N01.824.308.500.862'... | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
When the nurse encounters crying. | 1. Crying has therapeutic value. For the patient and family, crying can facilitate working through grief, promote emotional healing, and release emotions that might otherwise lead to crippling emotional or physical illness. 2. Crying may be precipitated by a variety of emotions and may be related to a variety of situat... | ['Adaptation, Psychological', 'Crying', 'Culture', 'Emotions', 'Empathy', 'Humans', 'Nurse-Patient Relations', 'Nursing Care'] | 1,561,707 | [['F01.058'], ['F01.145.209.530.258', 'F01.525.200.310.300'], ['I01.076.201.450', 'I01.880.853.100'], ['F01.470'], ['F01.752.355', 'F01.752.543.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.650.600', 'N05.300.660.560'], ['E02.760.611', 'N02.421.533']] | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Bottom-up and top-down herbivore regulation mediated by glucosinolates in Brassica oleracea var. acephala. | Quantitative differences in plant defence metabolites, such as glucosinolates, may directly affect herbivore preference and performance, and indirectly affect natural enemy pressure. By assessing insect abundance and leaf damage rate, we studied the responses of insect herbivores to six genotypes of Brassica oleracea v... | ['Animals', 'Aphids', 'Brassica', 'Genotype', 'Glucosinolates', 'Herbivory', 'Indoles', 'Insecta', 'Larva', 'Lepidoptera', 'Plant Leaves', 'Wasps'] | 24,352,843 | [['B01.050'], ['B01.050.500.131.617.412.165'], ['B01.650.940.800.575.912.250.157.200'], ['G05.380'], ['D02.886.740.703.350', 'D09.408.348.820.350', 'D09.408.903.703.350'], ['F01.145.113.547.600', 'F01.145.407.758', 'G07.203.650.353.758'], ['D03.633.100.473'], ['B01.050.500.131.617'], ['B05.500.500', 'G07.345.500.550.50... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Side chain conformational averaging in human dihydrofolate reductase. | The three-dimensional structures of the dihydrofolate reductase enzymes from Escherichia coli (ecDHFR or ecE) and Homo sapiens (hDHFR or hE) are very similar, despite a rather low level of sequence identity. Whereas the active site loops of ecDHFR undergo major conformational rearrangements during progression through t... | ['Crystallography, X-Ray', 'Escherichia coli', 'Humans', 'Models, Molecular', 'Protein Conformation', 'Tetrahydrofolate Dehydrogenase'] | 24,498,949 | [['E05.196.309.742.225'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['G02.111.570.820.709'], ['D08.811.682.662.825']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Small dense low-density lipoprotein cholesterol concentration and carotid atherosclerosis. | Low-density lipoprotein cholesterol (LDL-C) and the small dense LDL (SdLDL) phenotype are both predictors for ischemic heart disease. We examined whether cholesterol of SdLDL (SdLDL-C) is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and ... | ['Aged', 'Biomarkers', 'Carotid Artery Diseases', 'Cholesterol, LDL', 'Female', 'Humans', 'Hypercholesterolemia', 'Lipoproteins, LDL', 'Male', 'Middle Aged', 'Particle Size', 'Risk Assessment', 'Risk Factors', 'Tunica Intima', 'Tunica Media', 'Ultrasonography'] | 18,492,490 | [['M01.060.116.100'], ['D23.101'], ['C10.228.140.300.200', 'C14.907.253.123'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.584.500.500.396'], ['D10.532.515', 'D12.776.521.550'], ['M01.060.116.630'], ['G02.71... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation. | Zolpidem is a hypnotic benzodiazepine site agonist with some gamma-aminobutyric acid (GABA)(A) receptor subtype selectivity. Here, we have tested the effects of zolpidem on the hippocampus of gamma2 subunit (gamma2F77I) point mutant mice. Analysis of forebrain GABA(A) receptor expression with immunocytochemistry, quant... | ['Action Potentials', 'Animals', 'Binding, Competitive', 'Carbachol', 'Cholinergic Agonists', 'Drug Resistance', 'Female', 'GABA Agonists', 'Hippocampus', 'Interneurons', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Neurologic Mutants', 'Neural Inhibition', 'Point Mutation', 'Pyramidal Cells', 'Pyridines', 'Radioligand... | 15,978,011 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D02.092.877.883.333.115', 'D02.675.276.232.115'], ['D27.505.519.625.120.140', 'D27.505.696.577.120.140'], ['G07.690.773.984'], ['D27.505.519.625.240.200', 'D27.505.696.577.240.200'], ['A08.186.2... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity. | A common complication associated with diabetes is painful or painless diabetic peripheral neuropathy (DPN). The mechanisms and determinants responsible for these peripheral neuropathies are poorly understood. Using both streptozotocin (STZ)-induced and transgene-mediated murine models of type 1 diabetes (T1D), we demon... | ['Animals', 'Blood Glucose', 'Body Weight', 'Diabetes Mellitus, Experimental', 'Diterpenes', 'Ganglia, Spinal', 'Hot Temperature', 'Immunohistochemistry', 'Injections, Intraperitoneal', 'Ion Channel Gating', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Neurons', 'Pain', 'Streptozocin', 'TRPV Cation Channels', 'Tr... | 18,312,687 | [['B01.050'], ['D09.947.875.359.448.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['D02.455.849.291'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['G01.906.595... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Adiponectin, leptin and thyroid hormones in patients with chronic renal failure and on renal replacement therapy: are they related? | BACKGROUND: Renal function affects thyroid function and adipocytokines in many ways. We aimed to assess the adipocytokines adiponectin and leptin in relation to thyroid function in patients with chronic renal failure treated conservatively, in haemodialysed patients and in kidney allograft recipients.METHODS: The study... | ['Adiponectin', 'Analysis of Variance', 'Case-Control Studies', 'Cohort Studies', 'Disease Progression', 'Female', 'Humans', 'Kidney Failure, Chronic', 'Kidney Transplantation', 'Leptin', 'Linear Models', 'Male', 'Probability', 'Prognosis', 'Reference Values', 'Renal Dialysis', 'Renal Replacement Therapy', 'Risk Assess... | 16,141,459 | [['D06.472.699.042.249', 'D12.644.276.024.249', 'D12.644.548.011.249', 'D12.776.467.024.249', 'D23.529.024.249'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cystic resolution: a performance metric for ultrasound imaging systems. | This paper describes a metric that can be used to characterize the resolution of arbitrary broadband coherent imaging systems. The metric is particularly suited to medical ultrasound because it characterizes scanner performance using the contrast obtained by imaging anechoic cysts of various sizes that are embedded in ... | ['Algorithms', 'Artifacts', 'Equipment Failure Analysis', 'Image Interpretation, Computer-Assisted', 'Quality Control', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Ultrasonography'] | 17,441,587 | [['G17.035', 'L01.224.050'], ['E05.047'], ['E05.325.192'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['J01.897.608'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725',... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Cancer in the offspring of parents with lung cancer. | Despite several studies on the role of passive smoking in the development of childhood cancer, particularly leukaemia, lymphomas and brain cancer, no definitive answer has yet been provided. The aim of the cohort study reported here was to analyse the incidence of cancer in the offspring of young lung cancer patients o... | ['Adolescent', 'Adult', 'Age of Onset', 'Aged', 'Child', 'Child of Impaired Parents', 'Child, Preschool', 'Cohort Studies', 'Denmark', 'Female', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasms', 'Risk Factors', 'Tobacco Smoke Pollution'] | 9,616,284 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['M01.060.406'], ['M01.106'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['Z01.542.816.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.98... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
GAMETOPHYTE DEFECTIVE 1, a putative subunit of RNases P/MRP, is essential for female gametogenesis and male competence in Arabidopsis. | RNA biogenesis, including biosynthesis and maturation of rRNA, tRNA and mRNA, is a fundamental process that is critical for cell growth, division and differentiation. Previous studies showed that mutations in components involved in RNA biogenesis resulted in abnormalities in gametophyte and leaf development in Arabidop... | ['Amino Acid Sequence', 'Arabidopsis', 'Arabidopsis Proteins', 'Autoantigens', 'Endoribonucleases', 'Gametogenesis, Plant', 'Gene Expression Regulation, Plant', 'Humans', 'Molecular Sequence Data', 'Mutation', 'Pollen', 'Protein Subunits', 'RNA', 'RNA Processing, Post-Transcriptional', 'RNA, Mitochondrial', 'Ribonuclea... | 22,509,260 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['D23.050.422'], ['D08.811.277.352.355.350', 'D08.811.277.352.700.350'], ['G04.152.650.240', 'G08.686.784.310.249', 'G15.300'], ['G05.308.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Variations among rheumatologists in prescribing and monitoring of disease modifying antirheumatoid drugs. | One hundred consultant rheumatologists were sent a questionnaire on their prescribing pattern, and dose and monitoring schedules of four disease modifying antirheumatoid drugs (DMARDs). Seventy-five completed questionnaires were received. Sulphasalazine was the most popular first choice DMARD. There was general agreeme... | ['Antimalarials', 'Arthritis, Rheumatoid', 'Drug Administration Schedule', 'Drug Monitoring', 'Drug Prescriptions', 'Drug Utilization', 'Gold Sodium Thiomalate', 'Humans', 'Penicillamine', "Practice Patterns, Physicians'", 'Rheumatology', 'Sulfasalazine', 'Surveys and Questionnaires', 'United Kingdom'] | 1,352,723 | [['D27.505.954.122.250.100.085'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E02.319.283'], ['E01.370.520.200'], ['E02.319.307', 'N02.421.668.778.500'], ['N04.452.706.477'], ['D02.241.081.337.463.703.451', 'D02.691.675.500', 'D02.886.489.891.451'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Induction of c-fos by prostaglandin F2 alpha in human ciliary smooth muscle cells. | PURPOSE: To evaluate the induction of the proto-oncogene c-fos in cultured human ciliary muscle cells by prostaglandin F2 alpha (PGF2 alpha) by 17-phenyltrinor-PGF 2 alpha.METHOD: Human ciliary muscle cells were grown to confluency in monolayer cell culture, placed in medium containing 1% fetal bovine serum for 5 days,... | ['Cells, Cultured', 'Ciliary Body', 'Dinoprost', 'Dose-Response Relationship, Drug', 'Fluorescent Antibody Technique', 'Gene Expression', 'Humans', 'Middle Aged', 'Muscle, Smooth', 'Proto-Oncogene Proteins c-fos'] | 8,300,352 | [['A11.251'], ['A09.371.060.160', 'A09.371.894.280'], ['D10.251.355.255.550.400.200', 'D23.469.050.175.725.400.200'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['G05.297'], ['B01.050.15... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dominant-negative subunits reveal potassium channel families that contribute to M-like potassium currents. | M-currents are K+ currents generated by members of the KCNQ family of K+ channels (Wang et al., 1998). However, in some cells, M-like currents may be contaminated by members of other K+ channel gene families, such as the erg family (Meves et al., 1999; Selyanko et al., 1999). In the present experiments, we have used th... | ['Animals', 'Cells, Cultured', 'ERG1 Potassium Channel', 'Ether-A-Go-Go Potassium Channels', 'Gene Expression', 'Genes, Dominant', 'Hybrid Cells', 'KCNQ3 Potassium Channel', 'Mice', 'Multigene Family', 'Neuroblastoma', 'Neurons', 'Patch-Clamp Techniques', 'Potassium', 'Potassium Channels', 'Potassium Channels, Voltage-... | 11,880,533 | [['B01.050'], ['A11.251'], ['D12.776.157.530.400.600.900.249.500', 'D12.776.543.550.450.750.900.249.500', 'D12.776.543.585.400.750.900.249.500'], ['D12.776.157.530.400.600.900.249', 'D12.776.543.550.450.750.900.249', 'D12.776.543.585.400.750.900.249'], ['G05.297'], ['G05.360.340.024.340.240', 'G05.420.320'], ['A11.251.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Irreversible inhibitors of nicotinic acetylcholine receptors: isolation and structural characterization of the biologically active solvolysis products of bipinnatin-A and bipinnatin-C. | The lophotoxins irreversibly inhibit nicotinic acetylcholine receptors by covalent modification of Tyr190 in the alpha-subunits of the receptor. Previous studies have shown that the naturally occurring lophotoxin analogs bipinnatin-A, -B, and -C are actually inactive protoxins and that their ability to irreversibly inh... | ['Cell Line', 'Chromatography, High Pressure Liquid', 'Hydrolysis', 'Magnetic Resonance Spectroscopy', 'Molecular Structure', 'Nicotinic Antagonists', 'Sesquiterpenes', 'Solvents', 'Spectrometry, Mass, Fast Atom Bombardment'] | 7,783,154 | [['A11.251.210'], ['E05.196.181.400.300'], ['G02.380'], ['E05.196.867.519'], ['G02.111.570', 'G02.466'], ['D27.505.519.625.120.200.700', 'D27.505.696.577.120.200.700'], ['D02.455.849.765'], ['D27.720.844'], ['E05.196.566.750']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Angiotensin converting enzyme gene polymorphism and activity in Turkish patients with essential hypertension. | Studies in various ethnic groups have shown contradictory evidence on the association of the angiotensin converting enzyme (ACE) insertion/ deletion (I/D) polymorphism with essential hypertension. We conducted a case-control study in Samsun, Turkey, to examine the association between ACE genotype, ACE serum activity, a... | ['Adult', 'Aged', 'Female', 'Genotype', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Peptidyl-Dipeptidase A', 'Polymorphism, Genetic'] | 10,560,791 | [['M01.060.116'], ['M01.060.116.100'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['D08.811.277.656.350.350.687'], ['G05.365.795']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
In-vitro activity of meropenem, a new carbapenem, against imipenem-resistant Pseudomonas aeruginosa and Xanthomonas maltophilia. | The activity of meropenem, a new carbapenem, as well as imipenem, ceftazidime, aztreonam, tobramycin, amikacin and ciprofloxacin against 18 strains of Xanthomonas maltophilia and 23 strains of Pseudomonas aeruginosa resistant to imipenem was tested. All strains of X. maltophilia were resistant to both penems. Ceftazidi... | ['Anti-Bacterial Agents', 'Drug Resistance, Microbial', 'Imipenem', 'Meropenem', 'Microbial Sensitivity Tests', 'Pseudomonas aeruginosa', 'Thienamycins', 'Xanthomonas'] | 1,919,651 | [['D27.505.954.122.085'], ['G06.225', 'G07.690.773.984.269'], ['D02.065.589.099.124.300.500', 'D03.633.100.300.124.300.500'], ['D02.065.589.099.124.300.750', 'D03.633.100.300.124.300.750'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['B03.440.400.425.625.625.100', 'B03.660.250.580.590.050'], ['D02.0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Role of Wheat and Egg Constituents in the Formation of a Covalent and Non-covalent Protein Network in Fresh and Cooked Egg Noodles. | Noodles of constant protein content and flour-to-egg protein ratio were made with whole egg, egg white, or egg yolk. The optimal cooking time, water absorption, and cooking loss of salted whole egg noodles was respectively lower and higher than of egg white and egg yolk noodles. However, cooked whole egg noodles showed... | ['Albumins', 'Animals', 'Calorimetry, Differential Scanning', 'Chickens', 'Cooking', 'Cross-Linking Reagents', 'Egg White', 'Egg Yolk', 'Eggs', 'Flour', 'Food Analysis', 'Globulins', 'Hydrogen Bonding', 'Hydrophobic and Hydrophilic Interactions', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Molecular Weight', 'Sodiu... | 27,875,617 | [['D12.776.034'], ['B01.050'], ['E05.196.131.310', 'E05.196.370.310'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['J01.576.423.200.200'], ['D27.720.470.410.210'], ['G07.203.300.470.700', 'J02.500.470.700'], ['A16.690.325', 'G07.203.300.470.800', 'J02.500.470.800'], ['G07.203.300.470', 'J02.500.470... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Biosorption of lead(II) from aqueous solution by lactic acid bacteria. | The biosorption of Pb(II) from aqueous solutions by lactic acid bacterium, Lactobacillus brevis, was studied. The effects of initial pH, contact time, initial Pb(II) concentration, bacterial concentration, rotation speed and temperature of biosorption of Pb(II) from aqueous solutions were investigated. The optimal cond... | ['Adsorption', 'Biodegradation, Environmental', 'Hydrogen-Ion Concentration', 'Kinetics', 'Lactobacillales', 'Lead', 'Solutions', 'Thermodynamics', 'Water Pollutants, Chemical'] | 30,975,929 | [['G01.030', 'G02.020'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['B03.353.750', 'B03.510.550'], ['D01.268.556.435', 'D01.552.544.435'], ['D26.776'], ['G01.906'], ['D27.888.284.903.655']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Discovery of Biomarker Panels for Neural Dysfunction in Inborn Errors of Amino Acid Metabolism. | Patients with inborn errors of amino acid metabolism frequently show neuropsychiatric symptoms despite accurate metabolic control. This study aimed to gain insight into the underlying mechanisms of neural dysfunction. Here we analyzed the expression of brain-derived neurotrophic factor (BDNF) and 10 genes required for ... | ['Adolescent', 'Amino Acid Metabolism, Inborn Errors', 'Biomarkers', 'Brain', 'Child', 'Child, Preschool', 'Female', 'Gene Expression Regulation', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Synapses'] | 31,235,756 | [['M01.060.057'], ['C16.320.565.100', 'C18.452.648.100'], ['D23.101'], ['A08.186.211'], ['M01.060.406'], ['M01.060.406.448'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['A08.850', 'A11.284.149.165.420.780']] | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Self-nanoemulsifying drug delivery system of persimmon leaf extract: Optimization and bioavailability studies. | In current study, a self-nanoemulsifying drug delivery system (SNEDDS) of persimmon (Diospyros kaki) leaf extract (PLE) was developed and characterized to compare its in vitro dissolution and relative bioavailability with commercially available tablets (Naoxinqing tablets). Pseudo-ternary phase diagrams were constructe... | ['Administration, Oral', 'Animals', 'Biological Availability', 'Chemistry, Pharmaceutical', 'Chromatography, High Pressure Liquid', 'Diospyros', 'Dogs', 'Drug Carriers', 'Drug Compounding', 'Drug Stability', 'Drug Storage', 'Drugs, Chinese Herbal', 'Emulsions', 'Hydrolysis', 'Kaempferols', 'Nanoparticles', 'Nanotechnol... | 21,884,770 | [['E02.319.267.100'], ['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['H01.158.703.007', 'H01.181.466'], ['E05.196.181.400.300'], ['B01.650.940.800.575.912.250.341.875.500'], ['B01.050.150.900.649.313.750.250.216.200'], ['D26.255.260', 'E02.319.300.380'], ['E05.916.270'], ['E05.916.330'], ['E05.916.350'], ['D20.215.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Effect of atropine on vascular adrenergic neuroeffector transmission. | Atropine, homatropine, scopolamine, procaine, lidocaine and phentolamine inhibited the contractile response of rabbit isolated pulmonary artery elicited by electrical-field stimulation. Methylatropine had no effect. The inhibition induced by atropine (2 x 10(-6)-2 x 10(-4) M) had a rapid onset of action and then remain... | ['Amphetamine', 'Anesthetics, Local', 'Animals', 'Aorta, Thoracic', 'Atropine', 'Cocaine', 'Drug Antagonism', 'Electric Stimulation', 'Norepinephrine', 'Phentolamine', 'Pulmonary Artery', 'Rabbits', 'Receptors, Adrenergic', 'Receptors, Adrenergic, alpha', 'Receptors, Cholinergic', 'Receptors, Muscarinic', 'Scopolamine'... | 199,296 | [['D02.092.471.683.152.110'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['B01.050'], ['A07.015.114.056.372'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['D02.145.074.722.388', 'D03... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Studies on the efficient dual performance of Mn1-x | The present work describes the successful synthesize of spinel magnetic ferrite Mn1-xNixFe2O4 (x=0.0, 0.1, 0.2, 0.3, 0.4 & 0.5) nanoparticles via a simple microwave combustion method which was then evaluated for its photocatalytic activity in the degradation of indigo carmine (IC) synthetic dye, a major water pollutant... | ['Anti-Bacterial Agents', 'Bacteria', 'Crystallography, X-Ray', 'Luminescence', 'Magnetics', 'Metal Nanoparticles', 'Microbial Sensitivity Tests', 'Microscopy, Electron, Scanning', 'Photolysis', 'X-Ray Diffraction'] | 27,776,260 | [['D27.505.954.122.085'], ['B03'], ['E05.196.309.742.225'], ['G01.358.500.505.650.665', 'G01.590.540.665', 'G01.750.250.650.665', 'G01.750.770.578.665'], ['H01.671.493'], ['J01.637.512.600.500'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['G02.740.685... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
[Relationship of polymedication in controlling blood pressure: compliance, persistence, costs and incidence of new cardiovascular events]. | BACKGROUND AND OBJECTIVE: To determine the relationship of polypharmacy on blood pressure (BP) control, compliance, persistence, the cost and incidence of cardiovascular events (CVD) in patients with moderate/severe hypertension.PATIENTS AND METHODS: An observational multicenter retrospective study. We evaluated patien... | ['Absenteeism', 'Aged', 'Antihypertensive Agents', 'Blood Pressure', 'Cardiovascular Diseases', 'Comorbidity', 'Diagnostic Tests, Routine', 'Drug Resistance', 'Drug Therapy, Combination', 'Female', 'Health Care Costs', 'Health Resources', 'Humans', 'Hypertension', 'Incidence', 'Male', 'Medication Adherence', 'Middle Ag... | 22,766,057 | [['F02.784.692.107'], ['M01.060.116.100'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C14'], ['N05.715.350.225', 'N06.850.490.687'], ['E01.370.395'], ['G07.690.773.984'], ['E02.319.310'], ['N03.219.151.400', 'N05.300.375'], ['N03.349.340', 'N05.300.420'], ['B01.050.150.900.649.313.988.400.11... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Non-conventional antiphospholipid antibodies in patients with clinical obstetrical APS: Prevalence and treatment efficacy in pregnancies. | OBJECTIVES: To describe the prevalence of non-conventional APL in patients with obstetrical APS without conventional APL and the impact of treatment on pregnancy outcome.METHODS: Patients with clinical obstetrical criteria were tested for anti-phosphatidylethanolamine (aPE) IgG/M, anti-prothrombin/phosphatidylserine (a... | ['Adult', 'Antibodies, Antiphospholipid', 'Anticoagulants', 'Antiphospholipid Syndrome', 'Aspirin', 'Female', 'Heparin, Low-Molecular-Weight', 'Humans', 'Middle Aged', 'Pregnancy', 'Pregnancy Complications', 'Pregnancy Outcome', 'Prevalence', 'Treatment Outcome'] | 27,432,776 | [['M01.060.116'], ['D12.776.124.486.485.114.323.210', 'D12.776.124.790.651.114.323.210', 'D12.776.377.715.548.114.323.210'], ['D27.505.954.502.119'], ['C20.111.197'], ['D02.455.426.559.389.657.410.595.176'], ['D09.698.373.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G08.686.784.769... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Heat damage of cytoskeleton in erythrocytes increases membrane roughness and cell rigidity. | The intensity of erythrocyte membrane fluctuations was studied by laser interference microscopy (LIM), which provide information about mechanical properties of the erythrocyte membrane. Atomic force microscopy (AFM) was used to study erythrocyte surface relief; it is related to the cytoskeleton structure of erythrocyte... | ['Biomechanical Phenomena', 'Cytoskeleton', 'Erythrocyte Membrane', 'Erythrocytes', 'Hot Temperature', 'Mechanical Phenomena'] | 31,758,351 | [['G01.154.090', 'G01.374.089'], ['A11.284.430.214.190.750'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['G01.3... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Our experience in the surgical management of bull horn vascular injuries]. | Vascular trauma caused by bull horn injuries can be regarded as a subgroup of vascular traumatology, due to its particular etiology, mechanism of action, associated injuries and surgical management. In this paper, the authors report their experience in the management of 56 such injuries, for the last 20 years, analysin... | ['Adult', 'Athletic Injuries', 'Blood Vessels', 'Humans', 'Male', 'Vascular Surgical Procedures'] | 19,305,882 | [['M01.060.116'], ['C26.115'], ['A07.015'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.100.814']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
How do people with chronic kidney disease value cancer-related quality of life? | OBJECTIVES: To estimate the utility-based quality of life (QOL) of people with chronic kidney disease (CKD) and to estimate the QOL associated with two hypothetical colorectal cancer health states.METHODS: A cross-sectional study was conducted in people with CKD (stages 3-5, transplant recipients and those on dialysis)... | ['Adult', 'Aged', 'Australia', 'Chronic Disease', 'Colorectal Neoplasms', 'Comorbidity', 'Cross-Sectional Studies', 'Female', 'Humans', 'Kidney Diseases', 'Male', 'Middle Aged', 'Quality of Life', 'Renal Dialysis', 'Sickness Impact Profile', 'Socioeconomic Factors', 'Surveys and Questionnaires', 'Value of Life'] | 22,017,753 | [['M01.060.116'], ['M01.060.116.100'], ['Z01.639.100', 'Z01.678.100.373'], ['C23.550.291.500'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.372.500.875', 'N05.715.360.330... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Alcohol and statistics of causes of death in middle-aged men in Oslo. A forensic study]. | The study comprised male citizens of Oslo, aged 30-64 years, who died outside hospital and were autopsied at the Institute of Forensic Medicine, Rikshopsitalet, from 1984 to 1988. Of the 636 cases, 195 (30.7%) were classified as alcoholics and 441 as non-alcoholics. The cause of death remained unknown after autopsy and... | ['Accidents', 'Adult', 'Alcoholism', 'Cause of Death', 'Forensic Medicine', 'Humans', 'Male', 'Middle Aged', 'Norway', 'Suicide'] | 2,339,381 | [['N06.850.135'], ['M01.060.116'], ['C25.775.100.250', 'F03.900.100.350'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['H02.403.330', 'I01.198.780.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.542.816.374'], ['F0... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. | Embryonic morphogenesis is driven by a suite of cell behaviours, including coordinated shape changes, cellular rearrangements and individual cell migrations, whose molecular determinants are largely unknown. In the zebrafish, Dani rerio, trilobite mutant embryos have defects in gastrulation movements and posterior migr... | ['Animals', 'Cell Movement', 'Gastrula', 'Membrane Proteins', 'Mutation', 'Neurons', 'Signal Transduction', 'Zebrafish', 'Zebrafish Proteins'] | 12,105,418 | [['B01.050'], ['G04.198', 'G07.568.500.180'], ['A16.441'], ['D12.776.543'], ['G05.365.590'], ['A08.675', 'A11.671'], ['G02.111.820', 'G04.835'], ['B01.050.150.900.493.200.244.828'], ['D12.776.325.500']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Algae as an electron donor promoting sulfate reduction for the bioremediation of acid rock drainage. | This study assessed bioremediation of acid rock drainage in simulated permeable reactive barriers (PRB) using algae, Chlorella sorokiniana, as the sole electron donor for sulfate-reducing bacteria. Lipid extracted algae (LEA), the residues of biodiesel production, were compared with whole cell algae (WCA) as an electro... | ['Biodegradation, Environmental', 'Biological Oxygen Demand Analysis', 'Bioreactors', 'Chlorella', 'Copper', 'Electrons', 'Hydrogen-Ion Concentration', 'Models, Theoretical', 'Oxidation-Reduction', 'Sulfates', 'Sulfides', 'Sulfur-Reducing Bacteria', 'Water Pollutants, Chemical', 'Water Purification'] | 27,318,730 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['N06.850.460.350.080.500', 'N06.850.780.375.349'], ['E07.115', 'J01.897.120.115'], ['B01.650.940.150.469'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['G01.249.335', 'G01.358.500.750'], ['G02.300'], ['E05.599'], ['G02.700', 'G03.295.531'], ['D01.248.497... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Relative and absolute changes of activated platelets, microparticles and platelet aggregates after activation in vitro. | Standard flow cytometers provide relative numbers of activated platelets, microparticles, and platelet aggregates. With fluorescent beads it is now possible to determine absolute numbers. Whole blood and platelet-rich plasma were incubated with agonists (ADP, collagen, thrombin). CD62p expression, microparticle and pla... | ['Blood Platelets', 'Flow Cytometry', 'Hemostatics', 'Humans', 'P-Selectin', 'Platelet Activation', 'Platelet Aggregation', 'Thrombin'] | 10,461,010 | [['A11.118.188', 'A15.145.229.188'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['D27.505.954.502.270.463'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550.200.700.775', 'D... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of striatal ÄFosB in l-Dopa-induced dyskinesias of parkinsonian nonhuman primates. | Long-term dopamine (DA) replacement therapy in Parkinson's disease (PD) leads to the development of abnormal involuntary movements known as l-Dopa-induced dyskinesia (LID). The transcription factor ÄFosB that is highly up-regulated in the striatum following chronic l-Dopa exposure may participate in the mechanisms of a... | ['Animals', 'Animals, Genetically Modified', 'Disease Models, Animal', 'Dyskinesia, Drug-Induced', 'Female', 'Humans', 'Levodopa', 'Macaca fascicularis', 'Male', 'Neostriatum', 'Parkinson Disease', 'Protein Isoforms', 'Proto-Oncogene Proteins c-fos', 'Up-Regulation'] | 31,455,727 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C10.228.662.262.500', 'C10.597.350.275', 'C10.720.312', 'C23.888.592.350.275', 'C25.100.750', 'C25.723.705.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.092.311.200.480', 'D02.455.426.559.389.657.166.175.2... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nursing home food services linked with risk of malnutrition. | PURPOSE: Links between food service characteristics and residents' risk of malnutrition were examined.METHODS: Cognitively intact residents meeting inclusion criteria and living in one of 38 participating nursing homes were randomly sampled. The final sample consisted of 132 residents, who were screened for risk of mal... | ['Aged', 'Aged, 80 and over', 'Female', 'Food Service, Hospital', 'Geriatric Assessment', 'Homes for the Aged', 'Humans', 'Male', 'Malnutrition', 'Menu Planning', 'Nursing Homes', 'Nutritional Status', 'Risk Assessment'] | 17,346,371 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['J01.576.423.500.300', 'N02.278.216.500.968.374', 'N02.421.242.472', 'N04.452.442.452.422.374'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['J03.775.462', 'N02.278.825.462'], ['B01.0... | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
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