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Absence of 4,977-bp deletion of blood cell mitochondrial DNA in patients with young-onset Parkinson's disease.
|
Decreased mitochondrial Complex I activities and a 4,977-bp deletion in mitochondrial DNA (mtDNA) have been reported in patients with Parkinson's disease. Based on the assumption of possible links between this 4,977-bp deletion and the etiology of Parkinson's disease, we analyzed mtDNA of blood cells from 15 patients with young-onset Parkinson's disease after the DNA was amplified by polymerase chain reaction. We could not detect the 4,977-bp mtDNA deletion in any of these patients. This result suggests that Parkinson's disease is not a mitochondrial disease due to the 4,977-bp mtDNA deletion. The 4,977-bp deletion in mtDNA appears to be an age-related phenomenon.
|
['Adult', 'Age Factors', 'Base Composition', 'Blood Cells', 'Chromosome Deletion', 'DNA, Mitochondrial', 'Female', 'Humans', 'Male', 'Middle Aged', 'Models, Genetic', 'NAD(P)H Dehydrogenase (Quinone)', 'Parkinson Disease', 'Polymerase Chain Reaction']
| 7,785,427
|
[['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['G02.111.080'], ['A11.118', 'A15.145.229'], ['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G05.558.800.180', 'G05.700.131.500.500'], ['D13.444.308.283.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.599.395.397'], ['D08.811.682.608.800.500'], ['C10.228.140.079.862.500', 'C10.228.662.600.400', 'C10.574.928.750'], ['E05.393.620.500']]
|
['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 1
| 1
| 1
| 1
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Octa-Coordination and the Aqueous Ba(2+) Ion.
|
The hydration structure of Ba(2+) ion is important for understanding blocking mechanisms in potassium ion channels. Here, we combine statistical mechanical theory, ab initio molecular dynamics simulations, and electronic structure methods to calculate the hydration free energy and local hydration structure of Ba(2+)(aq). The predicted hydration free energy (-304 ± 1 kcal/mol) agrees with the experimental value (-303 kcal/mol) when a maximally occupied, unimodal inner solvation shell is treated. In the local environment defined by the first shell of hydrating waters, Ba(2+) is directly and stably coordinated by eight (8) waters. Octa-coordination resembles the crystal structure of Ba(2+) and K(+) bound in potassium ion channels, but differs from the local hydration structure of K(+)(aq) determined earlier.
|
['Barium', 'Cations, Divalent', 'Molecular Dynamics Simulation', 'Thermodynamics', 'Water']
| 26,085,171
|
[['D01.268.552.050', 'D01.268.556.062', 'D01.552.539.124', 'D01.552.544.062'], ['D01.248.497.300.333'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['G01.906'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']]
|
['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]']
| 0
| 0
| 0
| 1
| 1
| 0
| 1
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| 0
| 0
| 1
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| 0
| 0
|
The use of elastic intramedullary nailing in the stabilisation of paediatric fractures.
|
UNLABELLED: The treatment of paediatric long-bone fractures remains controversial. Elastic intramedullary nailing has been proposed as an alternative for the treatment of paediatric long-bone fractures.PATIENTS: We treated 68 children in a time span of 9 years with 32 fractures of the forearm, 27 fractures of the femur and nine fractures of the tibia. The mean age was 8.3 years and the mean admission time 2.6 days.RESULTS: Mean consolidation time was 7.9 weeks for the forearm fractures, 11.9 weeks for the femur fractures and 10.6 weeks for the tibial fractures. Full weight bearing for the latter two fracture types was allowed within the first week. There were no major complications. The complications encountered were three hydrops of the knee, four low-grade infections and one delayed union. Leg length discrepancy was only seen in five patients (18%) and was less than 2 cm.DISCUSSION: In femur fractures, we let the parents decide between skeletal traction and intramedullary rods. When confronted with the possible complications (operation-related complications and infection) compared to the advantages (early weight bearing and short admission time), they almost always choose the operative approach. In our opinion, elastic intramedullary nailing is an excellent treatment option for diaphyseal fractures in children with skeletal immaturity, especially of the femur.
|
['Bone Nails', 'Child', 'Elasticity', 'Female', 'Femoral Fractures', 'Forearm Injuries', 'Fracture Fixation, Intramedullary', 'Fracture Healing', 'Fractures, Bone', 'Humans', 'Leg Length Inequality', 'Male', 'Surgical Wound Infection', 'Tibial Fractures', 'Treatment Outcome']
| 16,214,465
|
[['E07.695.370.249', 'E07.858.442.660.460.249', 'E07.858.690.725.460.249'], ['M01.060.406'], ['G01.374.590'], ['C26.404.061', 'C26.558.276'], ['C26.088.268'], ['E04.555.300.300.300'], ['G16.762.891.500'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.099.655', 'C23.300.808'], ['C01.947.692', 'C23.550.767.925'], ['C26.404.875', 'C26.558.857'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]']
| 0
| 1
| 1
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Using Rasch modeling to re-evaluate three scales related to physical activity: enjoyment, perceived benefits and perceived barriers.
|
Studies suggest that enjoyment, perceived benefits and perceived barriers may be important mediators of physical activity. However, the psychometric properties of these scales have not been assessed using Rasch modeling. The purpose of this study was to use Rasch modeling to evaluate the properties of three scales commonly used in physical activity studies: the Physical Activity Enjoyment Scale, the Benefits of Physical Activity Scale and the Barriers to Physical Activity Scale. The scales were administered to 378 healthy adults, aged 25-75 years (50% women, 62% Whites), at the baseline assessment for a lifestyle physical activity intervention trial. The ConQuest software was used to assess model fit, item difficulty, item functioning and standard error of measurement. For all scales, the partial credit model fit the data. Item content of one scale did not adequately cover all respondents. Response options of each scale were not targeting respondents appropriately, and standard error of measurement varied across the total score continuum of each scale. These findings indicate that each scale's effectiveness at detecting differences among individuals may be limited unless changes in scale content and response format are made.
|
['Evaluation Studies as Topic', 'Exercise', 'Female', 'Health Behavior', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Models, Educational', 'Patient Acceptance of Health Care', 'Psychometrics', 'Surveys and Questionnaires']
| 16,849,389
|
[['E05.337', 'N05.715.360.335'], ['G11.427.410.698.277', 'I03.350'], ['F01.145.488'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695.470', 'N06.850.520.830.500.525', 'N06.850.520.830.600.800.450', 'N06.850.520.830.750.450'], ['M01.060.116.630'], ['E05.599.545', 'I02.903.302'], ['F01.100.150.750.500', 'F01.145.488.887.500', 'N05.300.150.800.500'], ['F04.711.780'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]']
| 0
| 1
| 0
| 0
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 1
| 0
|
Phytosteryl sinapates and vanillates: chemoenzymatic synthesis and antioxidant capacity assessment.
|
Phytosterols and their derivatives have attracted much attention because of their health benefits to humans and are widely used in food, pharmaceuticals, and cosmetics in the past decades. While most of the research has focused on free phytosterols and phytosteryl esters of fatty acids, few researches reported on phytosteryl phenolates, the esters of phytosterols with phenolic acids. Two novel group phytosteryl phenolates, namely phytosteryl sinapates and vanillates, were successfully chemoenzymatically synthesised in this work and their structures confirmed. Fourier transform infrared (FTIR) and high performance chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) using atmospheric pressure chemical ionisation (APCI) under both positive and negative ion modes were employed for this purpose. High antioxidant capacity of phytosteryl sinapates was observed using both oxygen radical absorbance capacity (ORAC) assay and cooked ground meat model system. Although phytosteryl vanillates showed lower antioxidant capacity than phytosteryl sinapates, they were stronger antioxidants than vanillic acid and vinyl vanillate in both assays employed. Conjugation of phytosterols with sinapic or vanillic acid rendered higher antioxidant capacity. Further studies on health benefits of phytosteryl sinapates and vanillates are necessary.
|
['Antioxidants', 'Chromatography, High Pressure Liquid', 'Coumaric Acids', 'Phytosterols', 'Spectroscopy, Fourier Transform Infrared', 'Tandem Mass Spectrometry', 'Vanillic Acid']
| 23,411,265
|
[['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['E05.196.181.400.300'], ['D02.241.223.200.210'], ['D04.210.500.247.808.756', 'D10.570.938.795', 'D23.704.500'], ['E05.196.712.726.676.700', 'E05.196.867.826.676.700'], ['E05.196.566.880'], ['D02.241.223.100.300.350.875', 'D02.241.511.390.350.875', 'D02.455.426.559.389.127.281.350.875', 'D02.455.426.559.389.657.654.638.875']]
|
['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 0
| 0
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Pediatric screening urinalysis: a difference-in-differences analysis of how a 2007 change in guidelines impacted use.
|
BACKGROUND: Practice guidelines can promote higher-quality care, yet they are inconsistently adopted. The purpose of this study is to evaluate the impact of a 2007 American Academy of Pediatrics recommendation to discontinue routine screening urinalysis in children.METHODS: Using data from the National Ambulatory Medical Care Survey, we used a difference-in-differences approach to estimate visit-level screening urinalysis proportions before (2005-2006, n = 1,247) and after (2008-2009, n = 1,772) the 2007 AAP recommendation. We compared visits by children 4-18 years old to visits by young adults aged 19-32. Analyses were adjusted for continuous patient age, patient race/ethnicity, physician specialty, and stratified by patient gender and visit setting.RESULTS: The 2007 recommendation was associated with no significant change in adjusted visit-level screening urinalysis proportions in child visits (20.4% to 22.5%) compared to an increase in young adult visits (20.1% to 27.0%) - a differential impact of -4.8 percentage points (95% Confidence Interval [CI] -9.0, -0.5). In private practices, visit proportions differentially decreased by 7.6 percentage points (95% CI -13.7, -1.5) in female children and by 0.5 percentage points (95% CI -10.6, 9.6) in male children. In community health centers, visit proportions differentially decreased by 17.4 percentage points (95% CI -27.9, -6.8) in female children and by 33.5 percentage points (95% CI -47.4, -19.7) in male children.CONCLUSIONS: A 2007 recommendation to discontinue routine screening urinalysis in children was associated with no change in use in child visits relative to an increase in use in adult visits. Overall, nearly one-quarter of child visits still included screening urinalysis.
|
['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Community Health Centers', 'Female', 'Health Care Surveys', 'Humans', 'Male', 'Mass Screening', 'Office Visits', 'Practice Guidelines as Topic', 'Preventive Health Services', 'Sex Distribution', 'United States', 'Urinalysis', 'Young Adult']
| 25,303,836
|
[['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['N02.278.035.128'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['N04.452.758.635'], ['N04.761.700.350.650', 'N05.700.350.650'], ['N02.421.726'], ['I01.240.800', 'N01.224.803', 'N06.850.505.400.850'], ['Z01.107.567.875'], ['E01.370.225.124.810', 'E01.370.390.810', 'E05.200.124.810'], ['M01.060.116.815']]
|
['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]']
| 0
| 1
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Ritualistic chewing behavior induced by mCPP in the rat is an animal model of obsessive compulsive disorder.
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Obsessive Compulsive Disorder (OCD) is characterized by recurrent, anxiety-producing thoughts accompanied by unwanted, overwhelming urges to perform ritualistic behaviors. Pharmacological treatments for this disorder (serotonin uptake inhibitors) are problematic because there is a 6-8 week delayed onset and half of the patients do not adequately respond. The present study evaluated whether Ritualistic Chewing Behaviors (RCBs) induced by the serotonin agonist mCPP in the rat is a behavioral model for OCD. The effects upon the RCBs induced by mCPP (1 mg/kg) were evaluated following treatments with either the serotonin antagonist mianserin (3 mg/kg), the dopamine antagonist haloperidol (1 mg/kg), the GABA modulator diazepam (10 mg/kg), or the serotonin uptake inhibitors clomipramine and fluvoxamine (15 mg/kg). The response to mCPP was blocked by acute treatment with mianserin, but not with acute haloperidol or diazepam. Further experiments revealed that the effects of mCPP were blocked by chronic, but not acute, treatment with clomipramine and fluvoxamine. A time-course demonstrated that 14 days of chronic treatment were required for blockade of the mCPP-evoked response. The current study demonstrates that mCPP-evoked RCBs may be a rodent model for OCD that can be used to predict the clinical efficacy and time course of novel OCD treatment. Future investigations may be able to use the current model as a tool for bench-marking corresponding changes in other measures of neurological activity that may provide insight into the mechanisms underlying OCD.
|
['Animals', 'Behavior, Animal', 'Clomipramine', 'Diazepam', 'Disease Models, Animal', 'Dopamine Antagonists', 'Fluvoxamine', 'GABA Modulators', 'Haloperidol', 'Male', 'Mastication', 'Mianserin', 'Obsessive-Compulsive Disorder', 'Piperazines', 'Rats', 'Rats, Sprague-Dawley', 'Serotonin Antagonists', 'Serotonin Receptor Agonists', 'Serotonin Uptake Inhibitors']
| 23,333,679
|
[['B01.050'], ['F01.145.113'], ['D03.633.300.240.194'], ['D03.633.100.079.080.070.216'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D27.505.519.625.150.175', 'D27.505.696.577.150.175'], ['D02.092.570.665.250'], ['D27.505.519.625.240.500', 'D27.505.696.577.240.500'], ['D02.522.352.506'], ['G07.203.650.283.500', 'G10.261.330.500'], ['D03.633.300.240.550'], ['F03.080.600'], ['D03.383.606'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D27.505.519.625.850.850', 'D27.505.696.577.850.850'], ['D27.505.519.625.850.800', 'D27.505.696.577.850.800'], ['D27.505.519.562.437.850', 'D27.505.519.625.600.850', 'D27.505.519.625.850.900', 'D27.505.696.577.600.850', 'D27.505.696.577.850.900']]
|
['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]']
| 0
| 1
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
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[Radiologic alternatives of splenectomy].
|
Partial peripheral splenic embolization can be performed in case of incurable thrombocytopenia due to hypersplenism without following splenectomy. A combined proximal and peripheral splenic embolization should only be carried out immediately prior to splenectomy if complications of hemorrhage due to extreme splenomegaly are to be expected. An only proximally performed occlusion can be by-bassed by collaterals. Anatomic blood vessel variations, techniques and complications are discussed in 6 cases.
|
['Combined Modality Therapy', 'Diatrizoate', 'Drug Combinations', 'Embolization, Therapeutic', 'Fatty Acids', 'Humans', 'Propylene Glycols', 'Proteins', 'Splenectomy', 'Splenic Diseases', 'Zein']
| 3,807,550
|
[['E02.186'], ['D02.241.223.100.400.880.270', 'D02.455.426.559.389.127.375.880.270'], ['D26.310'], ['E02.520.360', 'E02.926.500'], ['D10.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.455.706'], ['D12.776'], ['E04.726'], ['C15.604.744'], ['D12.776.765.433.500.750', 'D12.776.765.725.500.750']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]']
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Prediction for small subgroups.
|
Prediction limits are calculated for the number of events likely to occur in a specified time period in an exponentially growing epidemic. The basis for the prediction is the total number of events observed in the past.
|
['Acquired Immunodeficiency Syndrome', 'Humans', 'Mathematics', 'Models, Statistical', 'Probability']
| 2,572,018
|
[['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.548'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['E05.318.740.600', 'G17.680', 'N05.715.360.750.625', 'N06.850.520.830.600']]
|
['Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]']
| 0
| 1
| 1
| 0
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 1
| 0
|
Prophylactic and therapeutic effects of ciclosporin A in murine Schistosomiasis mansoni: studies on bisexual and unisexual infections and the hepatic inflammatory response.
|
Ciclosporin A (CsA), administered subcutaneously as 5 daily injections of 50 mg.kg-1, reduced the numbers of Schistosoma mansoni perfused from MF1 mice at 7 weeks post-infection. The timing of drug administration revealed that the antischistosomal effects were greater when CsA treatment coincided with or was within a few days of infection with the parasite. CsA exerted a clear prophylactic effect, which decreased with time and was virtually abolished by 4 months pre-infection. Adult worms treated in vivo were partially susceptible to CsA. In addition to its antiparasite action, CsA reduced hepatosplenomegaly due to schistosomiasis and diminished the granulomatous inflammatory response of mice to parasite eggs in the liver. The mode of action of CsA is not understood but evidence is presented that supports the proposition that the antiparasite effects are perhaps host-mediated.
|
['Animals', 'Cyclosporins', 'Female', 'Hepatitis', 'Liver', 'Male', 'Mice', 'Schistosomiasis mansoni', 'Sex Ratio']
| 3,123,398
|
[['B01.050'], ['D04.345.566.235', 'D12.644.641.235'], ['C06.552.380'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['C01.610.335.865.859.576', 'C01.920.922.576'], ['G05.815', 'I01.240.800.815', 'N01.224.803.815', 'N06.850.505.400.850.815']]
|
['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]']
| 1
| 1
| 1
| 1
| 0
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 1
| 0
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Do DSM-5 Section II personality disorders and Section III personality trait domains reflect the same genetic and environmental risk factors?
|
BACKGROUND: DSM-5 includes two conceptualizations of personality disorders (PDs). The classification in Section II is identical to the one found in DSM-IV, and includes 10 categorical PDs. The Alternative Model (Section III) includes criteria for dimensional measures of maladaptive personality traits organized into five domains. The degree to which the two conceptualizations reflect the same etiological factors is not known.METHODS: We use data from a large population-based sample of adult twins from the Norwegian Institute of Public Health Twin Panel on interview-based DSM-IV PDs and a short self-report inventory that indexes the five domains of the DSM-5 Alternative Model plus a domain explicitly targeting compulsivity. Schizotypal, Paranoid, Antisocial, Borderline, Avoidant, and Obsessive-compulsive PDs were assessed at the same time as the maladaptive personality traits and 10 years previously. Schizoid, Histrionic, Narcissistic, and Dependent PDs were only assessed at the first interview. Biometric models were used to estimate overlap in genetic and environmental risk factors.RESULTS: When measured concurrently, there was 100% genetic overlap between the maladaptive trait domains and Paranoid, Schizotypal, Antisocial, Borderline, and Avoidant PDs. For OCPD, 43% of the genetic variance was shared with the domains. Genetic correlations between the individual domains and PDs ranged from +0.21 to +0.91.CONCLUSION: The pathological personality trait domains, which are part of the Alternative Model for classification of PDs in DSM-5 Section III, appears to tap, at an aggregate level, the same genetic risk factors as the DSM-5 Section II classification for most of the PDs.
|
['Adolescent', 'Adult', 'Biometry', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Models, Statistical', 'Norway', 'Personality Disorders', 'Phenotype', 'Risk Factors', 'Young Adult']
| 28,414,014
|
[['M01.060.057'], ['M01.060.116'], ['E05.318.740.225', 'N06.850.505.200'], ['L01.453.245.945.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['Z01.542.816.374'], ['F03.675'], ['G05.695'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725'], ['M01.060.116.815']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]']
| 0
| 1
| 0
| 0
| 1
| 1
| 1
| 0
| 0
| 0
| 1
| 1
| 1
| 1
|
U.S. Army vector control (preventive medicine) operations during Operation Restore Hope, Somalia.
|
During the early stages of Operation Restore Hope, three U.S. Army preventive-medicine detachments were deployed to Somalia to counter the disease and non-battle injury threat to deployed forces. The activities of these units are discussed, with an emphasis on the entomology detachment. The preventive medicine (PVNTMED) threat facing deployed forces was considerable, and probably greater than that encountered in any recent operation. This threat is discussed, as are the methods used by the PVNTMED detachments to counter the threat. Vector control and pest management operations of the entomology detachment are highlighted, and how they related to the health and comfort of deployed personnel. These operations ranged from routine mosquito surveillance to large-area vector-control missions using a helicopter-slung pesticide dispersal unit. A variety of "lessons learned" are also discussed, focusing on individual and company-level PVNTMED measures.
|
['Animals', 'Communicable Disease Control', 'Disease Vectors', 'Health Promotion', 'Humans', 'Insect Control', 'Military Medicine', 'Military Personnel', 'Parasitic Diseases', 'Pest Control', 'Preventive Medicine', 'Somalia', 'United States']
| 8,918,117
|
[['B01.050'], ['N06.850.780.200'], ['N06.850.335.188', 'N06.850.520.203.375'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.780.200.650.425'], ['H02.403.500'], ['M01.526.625'], ['C01.610'], ['N06.850.780.200.650'], ['H02.403.720.750'], ['Z01.058.290.120.730'], ['Z01.107.567.875']]
|
['Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]']
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
| 0
| 1
| 1
| 1
|
The daughterless gene functions together with Notch and Delta in the control of ovarian follicle development in Drosophila.
|
The daughterless (da) gene in Drosophila encodes a broadly expressed transcriptional regulator whose specific functions in the control of sex determination and neurogenesis have been extensively examined. We describe here a third major developmental role for this regulatory gene: follicle formation during oogenesis. A survey of da RNA and protein distribution during oogenesis reveals a multiphasic expression pattern that includes both germline and soma. Whereas the germline expression reflects da's role in progeny sex determination, the somatic ovary expression of da correlates with the gene's role during egg chamber morphogenesis. Severe, but viable, hypomorphic da mutant genotypes exhibit dramatic defects during oogenesis, including aberrantly defined follicles and loss of interfollicular stalks. The follicular defects observed in da mutant ovaries are qualitatively very similar to those described in Notch (N) or Delta (Dl) mutant ovaries. Moreover, in the ovary da- alleles exhibit dominant synergistic interactions with N or Dl mutations. We propose that all three of these genes function in the same regulatory pathway to control follicle formation.
|
['Animals', 'Basic Helix-Loop-Helix Transcription Factors', 'DNA-Binding Proteins', 'Drosophila', 'Drosophila Proteins', 'Female', 'Genes, Regulator', 'Immunohistochemistry', 'In Situ Hybridization', 'Insect Hormones', 'Intracellular Signaling Peptides and Proteins', 'Membrane Proteins', 'Mutation', 'Nuclear Proteins', 'Oogenesis', 'Ovarian Follicle', 'Ovary', 'Phenotype', 'Receptors, Notch', 'Transcription Factors']
| 8,149,916
|
[['B01.050'], ['D12.776.260.103', 'D12.776.930.125'], ['D12.776.260'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['G05.360.340.024.340.425'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['D06.472.445.573'], ['D12.644.360', 'D12.776.476'], ['D12.776.543'], ['G05.365.590'], ['D12.776.660'], ['G04.152.650.249', 'G08.686.784.310.500'], ['A05.360.319.114.630.535', 'A06.300.312.497.535'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['G05.695'], ['D12.776.543.750.725', 'D12.776.930.770'], ['D12.776.930']]
|
['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
|
Engineering of an Episomal Plasmid Suitable for High-Throughput Expression in Pichia pastoris.
|
AIM AND OBJECTIVE: This study describes the design and evaluation of an expression vector for Pichia pastoris (pPICZáBHF), which is based on the commercial vector construct pPICZáB.MATERIAL AND METHODS: The performance of pPICZáBHF was evaluated with red fluorescent protein as a reporter. Additional His- and Flag-tags on the N-terminal ensured a simplified protein purification procedure. Transformation efficiency, expression level and plasmid maintenance were studied in order to test the functionality and usefulness of the constructed vector.RESULTS: We found that high transformation efficiencies were achieved using pPICZáBHF plasmid for yeast cell transformation in comparison with the commercial vector pPICZáB, which has to be integrated into the Pichia genome. However, expression levels of the recombinant protein were generally lower compared to the commercial construct. Recombinant plasmids were shown to be maintained in cells for approximately five days.CONCLUSION: Although pPICZáBHF may not be suitable for the production of high levels of recombinant protein, the simplicity of this P. pastoris expression system may still be of interest for the expression of proteins involved in cofactor regeneration or the expression of reporter genes. In addition, high transformation efficiency of pPICZáBHF may be beneficial for the applications such as high-throughput screening of mutant gene libraries.
|
['Gene Library', 'Genetic Engineering', 'Genetic Vectors', 'High-Throughput Nucleotide Sequencing', 'Pichia', 'Plasmids']
| 28,950,808
|
[['G05.360.325'], ['E05.393.420'], ['G05.360.337'], ['E05.393.760.319'], ['B01.300.107.795.700', 'B01.300.930.600'], ['G05.360.600']]
|
['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]']
| 0
| 1
| 0
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Derivation of species-specific hybridization-like knowledge out of cross-species hybridization results.
|
BACKGROUND: One of the approaches for conducting genomics research in organisms without extant microarray platforms is to profile their expression patterns by using Cross-Species Hybridization (CSH). Several different studies using spotted microarray and CSH produced contradicting conclusions in the ability of CSH to reflect biological processes described by species-specific hybridization (SSH).RESULTS: We used a tomato-spotted cDNA microarray to examine the ability of CSH to reflect SSH data. Potato RNA was hybridized to spotted cDNA tomato and potato microarrays to generate CSH and SSH data, respectively. Difficulties arose in obtaining transcriptomic data from CSH that reflected those obtained from SSH. Nevertheless, once the data was filtered for those corresponding to matching probe sets, by restricting proper cutoffs of probe homology, the CSH transcriptome data showed improved reflection of those of the SSH.CONCLUSIONS: This study evaluated the relative performance of CSH compared to SSH, and proposes methods to ensure that CSH closely reflects the biological process analyzed by SSH.
|
['Cluster Analysis', 'Gene Expression Profiling', 'Genes, Plant', 'Lycopersicon esculentum', 'Nucleic Acid Probes', 'Oligonucleotide Array Sequence Analysis', 'Principal Component Analysis', 'RNA, Messenger', 'Solanum tuberosum', 'Species Specificity']
| 16,677,401
|
[['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.393.332'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['B01.650.940.800.575.912.250.908.500.322'], ['D13.444.600', 'D27.505.259.750.600', 'D27.720.470.530.600'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['E05.318.740.562'], ['D13.444.735.544'], ['B01.650.940.800.575.912.250.908.500.725.777'], ['G16.824']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]']
| 0
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 0
|
The neural representation of consonant-vowel transitions in adults who wear hearing AIDS.
|
Hearing aids help compensate for disorders of the ear by amplifying sound; however, their effectiveness also depends on the central auditory system's ability to represent and integrate spectral and temporal information delivered by the hearing aid. The authors report that the neural detection of time-varying acoustic cues contained in speech can be recorded in adult hearing aid users using the acoustic change complex (ACC). Seven adults (50-76 years) with mild to severe sensorineural hearing participated in the study. When presented with 2 identifiable consonant-vowel (CV) syllables ("shee" and "see"), the neural detection of CV transitions (as indicated by the presence of a P1-N1-P2 response) was different for each speech sound. More specifically, the latency of the evoked neural response coincided in time with the onset of the vowel, similar to the latency patterns the authors previously reported in normal-hearing listeners.
|
['Aged', 'Auditory Pathways', 'Auditory Perception', 'Auditory Threshold', 'Electroencephalography', 'Electrophysiology', 'Evoked Potentials, Auditory', 'Female', 'Hearing Aids', 'Hearing Loss, Sensorineural', 'Humans', 'Male', 'Middle Aged', 'Speech Acoustics', 'Speech Perception', 'Treatment Outcome']
| 16,959,736
|
[['M01.060.116.100'], ['A08.612.220.110'], ['F02.463.593.071', 'G07.888.125'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['E01.370.376.300', 'E01.370.405.245'], ['H01.158.344.528', 'H01.158.782.236'], ['G07.265.216.500.370', 'G07.888.250', 'G11.561.200.500.370'], ['E07.305.906.500', 'E07.814.458'], ['C09.218.458.341.887', 'C10.597.751.418.341.887', 'C23.888.592.763.393.341.887'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G11.561.812.650', 'G11.561.820'], ['F02.463.593.071.875', 'G07.888.125.875'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Named Groups [M]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]']
| 1
| 1
| 1
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 1
| 1
| 0
|
[18S-25S rDNA variation in tissue culture of some Gentiana L. species].
|
18S-25S rDNA of intact plants and tissue cultures of G. acaulis, G. punctata and G. lutea have been investigated by using blot-hybridization. The decrease of rDNA amount was found in the callus cultures as compared with the plants. In contrast to other species, G. lutea showed intragenome heterogeneity of rRNA genes as well as qualitative rDNA changes in tissue culture, in particular appearance of altered repeats. The relationship between the peculiarities of rRNA gene structure and their rearrangements in in vitro culture was suggested.
|
['DNA, Plant', 'DNA, Ribosomal', 'Electrophoresis, Agar Gel', 'Gentiana', 'In Situ Hybridization', 'Polymorphism, Restriction Fragment Length', 'RNA, Ribosomal', 'RNA, Ribosomal, 18S', 'Tissue Culture Techniques']
| 17,494,339
|
[['D13.444.308.435'], ['D13.444.308.475'], ['E05.196.401.153', 'E05.301.300.100'], ['B01.650.940.800.575.912.250.456.750.391'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['G05.365.795.595'], ['D13.444.735.686'], ['D13.444.735.686.675'], ['E05.481.500.617']]
|
['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]']
| 0
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
[Anatomoclinical approach in idiopathic pulmonary hemosiderosis. Apropos of 12 cases].
|
Idiopathic pulmonary hemosiderosis (IPH) is an infrequent condition whose severe and unpredictable prognosis justifies extensive etiologic investigations. We have assembled 12 cases of IPH (nine children), three adults). In seven patients, pulmonary bleeding was demonstrated upon bronchoalveolar bleeding was demonstrated upon bronchoalveolar lavage (BAL) that recovered numerous hemosiderin-laden alveolar macrophages (Golde index: 247 +/- 53). All 12 patients underwent a surgical lung biopsy. Light microscopy studies showed hemosiderosis, often with lymphoid hyperplasia (n = 11), and occasionally with large germinal centers (n = 4), interstitial mastocytes (n = 7), ferric tattoo of the elastic network (n = 4), and a variable degree of interstitial necrosis (n = 4). Ultrastructural studies were performed in six cases and showed swelling of capillary endothelial cells (n = 5), interruptions in the endothelium (n = 3), tattoo of basement membranes (BMs) and elastic tissue (n = 3), intracapillary platelet aggregates (n = 2), and focal thickening of capillary BMs (n = 2). Four biopsies were studied using immunofluorescence (IF): no deposits of immune complexes were found. Indirect IF assays for antiglomerular and alveolar BMs was performed in two patients and was negative in both.
|
['Adolescent', 'Adult', 'Biopsy', 'Bronchoalveolar Lavage Fluid', 'Child', 'Child, Preschool', 'Female', 'Hemosiderosis', 'Humans', 'Infant', 'Lung Diseases', 'Male', 'Middle Aged']
| 2,818,000
|
[['M01.060.057'], ['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E05.927.100.500'], ['M01.060.406'], ['M01.060.406.448'], ['C18.452.565.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C08.381'], ['M01.060.116.630']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]']
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Diffusion tensor invasive phenotypes can predict progression-free survival in glioblastomas.
|
INTRODUCTION: Glioblastomas multiformes (GBM) remain incurable in most cases. Their invasion into normal brain makes current therapies ineffective. Post-mortem studies suggest about a 25% of GBMs invade less than 1 cm from the tumour bulk and 20% invade more than 3 cm.AIM OF STUDY: The study aims to use DTI to assess tumour extension and determine how previously reported patterns relate to the progression-free survival (PFS).MATERIALS AND METHODS: Twenty-five patients with GBM treated according to the EORTC/NCIC protocol were retrospectively analysed. Patients were imaged post-operatively at 1.5 T. The sequences were composed of standard anatomical and a standard DTI sequence. As described earlier p and q maps were constructed. For each of the p and q maps, regions of interest were drawn around the visible abnormality. Patients were assigned a diffuse, localised or minimally invasive pattern. Progression was defined according to the RANO criteria (4) and PFS determined in days. Kaplan-Meier plots of survival for the three groups were plotted as were the proportion of patients who had not progressed at 24 months.RESULTS: The median PFS for the diffuse group was 278 days, for the localised group 605 days and 820 days for the minimally invasive group. Three-fourth of the minimally invasive group were progression-free at 24 months (LOG RANK 9.25; p = 0.010).CONCLUSION: It is possible to identify three invasive phenotypes in GBMs using Diffusion tensor imaging , and these three phenotypes have different progression free survival. A minimal phenotype (20% of patients) predicts a greater delay to progression.
|
['Adult', 'Aged', 'Antineoplastic Protocols', 'Brain Neoplasms', 'Diffusion Tensor Imaging', 'Disease-Free Survival', 'Female', 'Follow-Up Studies', 'Glioblastoma', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Phenotype', 'Prognosis', 'Retrospective Studies', 'Treatment Outcome']
| 23,445,331
|
[['M01.060.116'], ['M01.060.116.100'], ['E02.183.750', 'E02.319.077', 'N05.715.360.330.125.500'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C04.557.465.625.600.380.080.335', 'C04.557.470.670.380.080.335', 'C04.557.580.625.600.380.080.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['M01.060.116.630'], ['G05.695'], ['E01.789'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]']
| 0
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Severe hypernatremic dehydration in an infant with Netherton syndrome.
|
Netherthon syndrome is a rare autosomal recessive disease characterized by ichthyosis, the characteristic hair abnormality trichorrhexis invaginata and atopic manifestations. We report a female child with the severe hypernatremic dehydration form of the Netherton syndrome born as the first child of consanguineous parents. Ichthyosis was present at birth. She was admitted to the intensive care unit at the age of 4 days with important loss of weight and dehydration. Severe hypernatremia and convulsions occurred. Despite intensive care the baby died at the age of 11 days. The diagnosis of Netherton syndrome was confirmed by the finding of the pathognomonic hair shaft anomaly trichorrhexis invaginata (bamboo hair) and premature lamellar body secretion and foci of electron-dense material in the intercellular spaces of stratum corneum as relatively specific markers for Netherton syndrome. Netherton syndrome is characterized by a large variability in phenotypic expression. The major neonatal complication is the hypernatremic dehydration, which can be fatal as in this patient or complicated by neurologic signs (intracranial hemorrhage) and secondary sequellae. Molecular studies revealed a mutation in SPINK 5, encoding a serine protease inhibitor. Prenatal diagnosis was performed in the second pregnancy and showed that the fetus was equally affected.
|
['Carrier Proteins', 'Chromosomes, Human, Pair 5', 'Consanguinity', 'DNA Mutational Analysis', 'Dehydration', 'Female', 'Hair', 'Humans', 'Hypernatremia', 'Ichthyosiform Erythroderma, Congenital', 'Infant, Newborn', 'Proteinase Inhibitory Proteins, Secretory', 'Serine Peptidase Inhibitor Kazal-Type 5', 'Serine Proteinase Inhibitors', 'Skin', 'Syndrome']
| 11,693,786
|
[['D12.776.157'], ['A11.284.187.520.300.280.290', 'G05.360.162.520.300.280.290'], ['G05.090.403.180', 'G05.180'], ['E05.393.760.700.300'], ['C18.452.950.179', 'C23.550.274'], ['A17.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.950.452'], ['C16.131.831.512.400', 'C16.320.850.400', 'C16.614.492.400', 'C17.800.428.333.250', 'C17.800.804.512.400', 'C17.800.827.400'], ['M01.060.703.520'], ['D12.644.822', 'D12.776.645'], ['D12.644.822.750.250', 'D12.776.645.688.250'], ['D27.505.519.389.745.800'], ['A17.815'], ['C23.550.288.500']]
|
['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Segment-specific retention of a larval neuromuscular system and its role in a new, rhythmic, pupal motor pattern in Manduca sexta.
|
At pupation in Manduca sexta, accessory planta retractor muscles and their motoneurons degenerate in segment-specific patterns. Accessory planta retractor muscles in abdominal segments 2 and 3 survive in reduced form through the pupal stage and degenerate after adult emergence. Electromyographic and electrophysiological recordings show that these accessory planta retractor muscles participate in a new, rhythmic 'pupal motor pattern' in which all four muscles contract synchronously at approximately 4 s intervals for extended bouts. Accessory planta retractor muscle contractions are driven by synaptic activation of accessory planta retractor motoneurons and are often accompanied by rhythmic activity in intersegmental muscles and spiracular closer muscles. The pupal motor pattern is influenced by descending neural input although isolated abdominal ganglia can produce a pupal motor pattern-like rhythm. The robust pupal motor pattern first seen after pupal ecdysis weakens during the second half of pupal life. Anemometric recordings indicate that the intersegmental muscle and spiracular closer muscle component of the pupal motor pattern produces ventilation. Accessory planta retractor muscle contractions lift the flexible abdominal floor, to which the developing wings and legs adhere tightly. We hypothesize that, by a bellows-like action, the accessory planta retractor muscle contractions circulate hemolymph in the appendages. Morphometric analysis shows that dendritic regression is similar in accessory planta retractor motoneurons with different pupal fates, and that accessory planta retractor motoneurons begin to participate in the pupal motor pattern while their dendrites are regressed.
|
['Animals', 'Dendrites', 'Electromyography', 'Electrophysiology', 'Larva', 'Manduca', 'Motor Neurons', 'Movement', 'Muscles', 'Nerve Degeneration', 'Pupa']
| 9,763,701
|
[['B01.050'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['E01.370.405.255', 'E01.370.530.255'], ['H01.158.344.528', 'H01.158.782.236'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.500.131.617.720.500.500.937.650.525'], ['A08.675.655.500', 'A11.671.655.500'], ['G07.568', 'G11.427.410'], ['A02.633', 'A10.690'], ['C23.550.737'], ['B05.500.700', 'G07.345.500.550.500.700']]
|
['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Diseases [C]']
| 1
| 1
| 1
| 0
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
|
Eczema prevalence in the United States: data from the 2003 National Survey of Children's Health.
|
Using the 2003 National Survey of Children's Health sponsored by the federal Maternal and Child Health Bureau, we calculated prevalence estimates of eczema nationally and for each state among a nationally representative sample of 102,353 children 17 years of age and under. Our objective was to determine the national prevalence of eczema/atopic dermatitis in the US pediatric population and to further examine geographic and demographic associations previously reported in other countries. Overall, 10.7% of children were reported to have a diagnosis of eczema in the past 12 months. Prevalence ranged from 8.7 to 18.1% between states and districts, with the highest prevalence reported in many of the East Coast states, as well as in Nevada, Utah, and Idaho. After adjusting for confounders, metropolitan living was found to be a significant factor in predicting a higher disease prevalence with an odds ratio of 1.67 (95% confidence interval of 1.19-2.35, P=0.008). Black race (odds ratio 1.70, P=0.005) and education level in the household greater than high school (odds ratio 1.61, P=0.004) were also significantly associated with a higher prevalence of eczema. The wide range of prevalence suggests that social or environmental factors may influence disease expression.
|
['Adolescent', 'African Americans', 'Asthma', 'Child', 'Child, Preschool', 'Eczema', 'Educational Status', 'Environment', 'European Continental Ancestry Group', 'Female', 'Health Surveys', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Multivariate Analysis', 'Prevalence', 'Rhinitis, Allergic, Seasonal', 'United States', 'Urban Population']
| 20,739,951
|
[['M01.060.057'], ['M01.686.508.100.100', 'M01.686.754.100'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406'], ['M01.060.406.448'], ['C17.800.174.620', 'C17.800.815.620'], ['N01.824.196'], ['G16.500.275', 'N06.230'], ['M01.686.508.400'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['C08.460.799.315.750', 'C08.674.453.750', 'C09.603.799.315.750', 'C20.543.480.680.443.750'], ['Z01.107.567.875'], ['N01.600.900']]
|
['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]']
| 0
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 1
|
[Neuronavigation-assisted resection of gliomas near eloquent regions].
|
OBJECTIVE: To evaluate the effect of the neuronavigation system in operation of gliomas near eloquent regions.METHOD: The brain LAB VV2 navigation system was used in 11 patients with gliomas near eloquent regions. The value of this system for glioma resection was assessed, and the accuracy and notice for application were discussed.RESULTS: The mean registration error was (1.5 +/- 0.7) mm in the patients. Total lesion removal was achieved in 9 patients (81.8%). The clinical status of all patients improved, and their functions of motor were not significantly affected. No complications were attributed to the use of this system.CONCLUSION: The neuronavigation system is reliable and accurate in surgical treatment of gliomas near eloquent regions. It increases the fraction of radical in glioma resection without injury to the critical functions.
|
['Adolescent', 'Adult', 'Brain Neoplasms', 'Female', 'Glioma', 'Humans', 'Male', 'Middle Aged', 'Neuronavigation', 'Neurosurgical Procedures', 'Treatment Outcome']
| 16,201,175
|
[['M01.060.057'], ['M01.060.116'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.525.800.324', 'E04.749.250', 'E05.873.249'], ['E04.525'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]']
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Risk of complications of first metatarsal head osteotomies with biodegradable pin fixation: Biofix versus Orthosorb.
|
Bioabsorbable materials for fracture repair have recently become available in the United States. These products have been especially attractive to surgeons that perform elective foot surgeries because an additional surgery is not required to remove internal fixation, and exposed pins and their complications can be avoided. The aim of this study was to compare complications in distal first metatarsal head osteotomies fixed with Biofix, polyglycolide pins and Orthosorb, polydioxanon pins. The authors identified nine patients with 11 distal first metatarsal osteotomies repaired with Biofix and 28 patients with 34 osteotomies repaired with Orthosorb from surgery logs for a 2-year period. The authors abstracted medical records and radiographs to identify sterile sinus formation, non-unions, malunions, and osteolytic lesions. The age and gender of patients in the Orthosorb and Biofix groups were similar. Six osteotomies in five patients in the Biofix group demonstrated bone resorption and osteolytic changes involving the osteotomy. Two of these patients also had a dorsally subluxed malunion of the first metatarsal head. There was one dorsally subluxed malunion in the Orthosorb group. No sterile sinus tracts were identified in either group. Complications were more common in distal first metatarsal osteotomies fixed with Biofix compared with Orthosorb (Biofix 55%, Orthosorb 3%, p < 0.001, odds ratio: 39.6, confidence interval (CI) = 3.9-401.6). Complications in the Biofix group were significantly more common in patients 50 years of age and older (p < 0.05).
|
['Adult', 'Age Factors', 'Aged', 'Biodegradation, Environmental', 'Bone Nails', 'Female', 'Fractures, Malunited', 'Humans', 'Male', 'Metatarsus', 'Middle Aged', 'Osteolysis', 'Osteotomy', 'Postoperative Complications']
| 7,951,184
|
[['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['E07.695.370.249', 'E07.858.442.660.460.249', 'E07.858.690.725.460.249'], ['C26.404.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.250.300.480'], ['M01.060.116.630'], ['C05.116.264.579', 'G11.427.213.150.570'], ['E04.555.580'], ['C23.550.767']]
|
['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]']
| 1
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Effects of continuous use of Entonox in comparison with intermittent method on obstetric outcomes: a randomized clinical trial.
|
BACKGROUND: Entonox (N2O2) which is an inhalational gas for relieving labor pain is commonly used intermittently; however some women are interested in continuous breathing in face mask. So we decided to compare the complications induced by two methods to find out whether it is safe to permit the mothers to use Entonox continuously or not.PATIENTS AND METHODS: This randomized clinical trial was performed in Mobini Hospital, Sabzevar, Iran. 50 parturients used Entonox intermittently and 50 cases used it continuously during labor. Then obstetrical outcomes were analyzed in two groups by spss 17 software, t-test, and Chi(2) while P < 0.05 was considered significant.RESULTS: This study showed the mean duration of second stage of labor had no significant difference (P = 0.3). Perineal laceration was less in continuous group significantly (P = 0.04). Assisted vaginal birth was not different significantly (P = 0.4). Uterine atony had no significant difference in two groups (P = 0.2). Maternal collaboration in pushing and satisfaction were higher in continuous group significantly (P = 0.03), (P < 0.0001). Apgar score of neonates at first and fifth minute was acceptable and not different significantly in two groups (P = 0.3).CONCLUSIONS: Our study demonstrated continuous method is also safe. So, it seems reasonable to set mothers free to choose the desired method of Entonox usage.
|
['Analgesics', 'Anesthesia, Obstetrical', 'Apgar Score', 'Delivery, Obstetric', 'Female', 'Humans', 'Labor Pain', 'Nitrous Oxide', 'Oxygen', 'Pregnancy', 'Pregnancy Outcome', 'Young Adult']
| 25,525,519
|
[['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['E03.155.364'], ['E01.370.600.050'], ['E04.520.252'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612.451'], ['D01.362.635.625', 'D01.625.550.550', 'D01.650.550.587.650'], ['D01.268.185.550', 'D01.362.670'], ['G08.686.784.769'], ['E01.789.700', 'G08.686.784.769.496'], ['M01.060.116.815']]
|
['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]']
| 0
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Use of the progression of adapted Diabetes Complications Severity Index to predict acute coronary syndrome, ischemic stroke, and mortality in Asian patients with type 2 diabetes mellitus: A nationwide cohort investigation.
|
BACKGROUND: We report on a retrospective population study aimed at identifying and validating the progression of adapted Diabetes Complications Severity Index (DCSI) for acute coronary syndrome (ACS), ischemic stroke, and mortality in Asian people with type 2 diabetes mellitus (DM).METHODS: Utilizing a Taiwanese national dataset, we included 84 450 type 2 diabetic individuals between 2000 and 2011. The area under the receiver operating characteristic curve (C statistics of logistic model) and the C statistics of the Cox model were used to evaluate whether the progression of diabetic complication status could be a predictor of ACS, ischemic stroke, and death. The optimum threshold for adverse outcomes risk stratification were obtained using Youden's J statistic as the cutoff that gives the highest threshold.RESULTS: Among the study patients, the C statistics of the logistic model of the progression of the score predictive of ACS, ischemic stroke, and death were 0.72 (95% confidence interval [CI]: 0.71-0.73), 0.84 (95% CI: 0.84-0.85), and 0.66 (95% CI: 0.65-0.67), respectively. The progression of adapted DCSI had moderate discrimination for ACS, ischemic stroke, and death (C statistics = 0.71, 0.72, and 0.75, respectively) based on Cox regression analysis (Harrell C). The optimum threshold of the progression of the score for ACS, ischemic stroke, and death in type 2 DM patients were 0.30, 0.36, and 0.39, respectively.CONCLUSIONS: The acceptable discriminative power of the progression of adapted DCSI for Asian people affected by type 2 DM was demonstrated in a large cohort in Taiwan.
|
['Acute Coronary Syndrome', 'Aged', 'Aged, 80 and over', 'Brain Ischemia', 'Diabetes Complications', 'Diabetes Mellitus, Type 2', 'Disease Progression', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'ROC Curve', 'Retrospective Studies', 'Risk Assessment', 'Risk Factors', 'Severity of Illness Index', 'Survival Rate', 'Taiwan', 'Time Factors']
| 29,896,758
|
[['C14.280.647.124', 'C14.907.585.124'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.300.150', 'C14.907.253.092'], ['C19.246.099'], ['C18.452.394.750.149', 'C19.246.300'], ['C23.550.291.656'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.700.680', 'N06.850.520.445.800.750'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500'], ['E05.318.308.985.550.900', 'N01.224.935.698.826', 'N06.850.505.400.975.550.900', 'N06.850.520.308.985.550.900'], ['Z01.252.474.872', 'Z01.639.850'], ['G01.910.857']]
|
['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]']
| 0
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 1
|
[Surgical treatment of lung cancer patients with brain metastases].
|
The authors present an experience with diagnosing and treatment of 16 patients suffering from lung cancer with solitary metastasis into the brain. The examination performed has shown that in 7 out of 16 patients the surgical treatment was found to be not expedient. This solution was based on the detection of an extensive spread of lung cancer: multiple metastasis outside the thoracic cavity and the brain or inside the brain, and in one case--due to a considerable reduction of indices of the functional and reserve capacities of respiration and blood circulation. Single-step operations were carried out in 9 patients with lung cancer with a solitary metastasis into the brain (resection of the lung with an ablation of the brain metastasis). Out of the 9 patients operated on 6 patients survived for as long as 1.5 to 2 years, one patient lived longer than 4 years. Two other patients operated upon in June 2003 and March 2004 are still alive and feel much better. Satisfactory results of treatment of these patients show such methods to be expedient.
|
['Adenocarcinoma', 'Adult', 'Aged', 'Brain Neoplasms', 'Carcinoma, Small Cell', 'Carcinoma, Squamous Cell', 'Female', 'Humans', 'Lung', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Pneumonectomy', 'Time Factors', 'Treatment Outcome']
| 15,957,816
|
[['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C04.557.470.200.380'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['E01.789.625'], ['E04.620', 'E04.928.600.600'], ['G01.910.857'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]']
| 1
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Diffeomorphic nonlinear transformations: a local parametric approach for image registration.
|
Many types of transformations are used to model deformations in medical image registration. While some focus on modeling local changes, some on continuity and invertibility, there is no closed-form nonlinear parametric approach that addresses all these properties. This paper presents a class of nonlinear transformations that are local, continuous and invertible under certain conditions. They are straightforward to implement, fast to compute and can be used particularly in cases where locally affine deformations need to be recovered. We use our new transformation model to demonstrate some results on synthetic images using a multi-scale approach to multi-modality mutual information based image registration. The original images were deformed using B-splines at three levels of scale. The results show that the proposed method can recover these deformations almost completely with very few iterations of a gradient based optimizer.
|
['Algorithms', 'Artificial Intelligence', 'Brain', 'Humans', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'Imaging, Three-Dimensional', 'Magnetic Resonance Imaging', 'Nonlinear Dynamics', 'Pattern Recognition, Automated', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Subtraction Technique']
| 17,354,694
|
[['G17.035', 'L01.224.050'], ['G17.035.250', 'L01.224.050.375'], ['A08.186.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E01.370.350.400', 'L01.224.308.410'], ['E01.370.350.825.500'], ['E05.599.850', 'H01.548.675'], ['L01.399.750'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['E01.370.350.760']]
|
['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]']
| 1
| 1
| 0
| 0
| 1
| 0
| 1
| 1
| 0
| 0
| 1
| 0
| 1
| 0
|
Renal artery origins: location and distribution in the transverse plane at CT.
|
PURPOSE: To determine the in situ location and distribution of the renal artery origins in the transverse plane with computed tomography (CT).MATERIALS AND METHODS: CT scans of the paired main renal arteries in 200 patients (89 men, 111 women) were retrospectively reviewed. The locations of the renal artery origins, defined on the basis of their optimal profile angles, and the angle between them were measured. The degree of aortic atherosclerosis was graded in 119 of the 200 patients.RESULTS: The origins of 400 paired main renal arteries were identified. A statistically significant difference was found between the average best profile angle on the right (24 degrees [range, 26 degrees-70 degrees]) and that on the left (5 degrees [range, -75 degrees to 38 degrees]) (P < .001). Truly laterally located renal arteries were seen on the right in 11 (5%) of 200 right renal arteries and on the left in 56 (28%) of 200 left renal arteries. One hundred eighty-six (93%) of 200 right ostia and only 40 (20%) of 200 left ostia were in an anterolateral location. One hundred four (52%) of 200 left ostia and three (2%) of 200 right ostia were in a posterolateral location. The prevalence of truly opposite renal arteries was 17%. The average profile angle between the renal artery origins was 161 degrees (range, 72 degrees-225 degrees) and was significantly larger in women (P = .001). No relationship was found between ostial location and patient age or atherosclerotic grade.CONCLUSION: In the transverse plane, the location of the origin of the right renal artery tended to be anterolateral and of the left renal artery tended to be posterolateral or lateral. The variation in location and distribution width was great.
|
['Aortic Diseases', 'Arteriosclerosis', 'Female', 'Humans', 'Male', 'Reference Values', 'Renal Artery', 'Retrospective Studies', 'Tomography, X-Ray Computed']
| 9,122,418
|
[['C14.907.109'], ['C14.907.137.126'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.978.810'], ['A07.015.114.745'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']]
|
['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
|
Towards the identification of subjects prone to develop atrial fibrillation after coronary artery bypass graft surgery via univariate and multivariate complexity analysis of heart period variability.
|
The assessment of cardiovascular control complexity as derived from spontaneous heart period (HP) fluctuations can be improved by exploiting a multivariate (MV) approach. This work proposes the assessment of a normalized complexity index (NCI) of HP variability according to a k-nearest-neighbor approach based on local predictability performed in a MV nonuniform embedding space. The method allows the selection of the past components of HP, systolic arterial pressure (SAP) and respiration (R) most useful for the prediction of HP fluctuations. The NCI derived from the MV approach (NCIMV) was compared to a NCI computed via the same technique applied in a univariate (UV) embedding space (NCIUV) formed exclusively by HP past samples. Indexes were computed in 130 patients undergoing coronary artery bypass graft (CABG) surgery before and after the induction of general anesthesia. Thirty-eight subjects developed atrial fibrillation (AF) after surgery, while the remaining ones did not (noAF, n=92). Both NCIUV and NCIMV could separate AF from noAF patients and revealed a larger complexity of the AF subjects. However, the statistical power of the NCIMV was superior given that the probability of type I error was smaller than that of NCIUV. The assessment of cardiac control complexity could improve risk stratification of patients at risk of developing AF after CABG surgery.
|
['Atrial Fibrillation', 'Cardiovascular System', 'Coronary Artery Bypass', 'Heart', 'Humans', 'Postoperative Complications', 'Systems Analysis']
| 29,060,560
|
[['C14.280.067.198', 'C23.550.073.198'], ['A07'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.767'], ['L01.906']]
|
['Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
| 0
|
Change, change, change: hormonal actions depend on changes in blood levels.
|
The main hypothesis outlined in this communication is that changes in hormonal levels are of utmost importance in the female reproductive system physiology. Hormone measurements must be assessed in the context of time and change. We hypothesize that changes in hormone concentrations carry significant biological messages, much more than a given level at a given time point and if proved, this theory could give rise to better approaches to treatment, and risk assessment.
|
['Chorionic Gonadotropin', 'Estradiol', 'Female', 'Hormones', 'Humans', 'Luteinizing Hormone', 'Ovulation Induction', 'Progesterone', 'Reproduction', 'Reproductive Techniques, Assisted']
| 18,326,517
|
[['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D06.472', 'D27.505.696.399.472'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.322.576.463', 'D06.472.699.631.525.343.463', 'D12.644.548.691.525.343.463'], ['E02.875.800.984', 'E05.820.800.984'], ['D04.210.500.745.745.654.829', 'D06.472.334.734.623', 'D06.472.334.851.687.750'], ['G08.686.784'], ['E02.875.800', 'E05.820.800']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]']
| 0
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Case control study of thermal environment preceding haemorrhagic shock encephalopathy syndrome.
|
The purpose of the study was to investigate whether the thermal environment in which babies slept before developing haemorrhagic shock encephalopathy syndrome (HSES) differed from that of other babies. Data were collected by standardised interview from parents of 31 babies who had had HSES before the age of 7 months and compared with equivalent data for 124 control babies, with matching for outside temperature on the relevant night and for age. Multivariate analysis showed a strong association between HSES and covering of the baby's head by bedding, the odds ratio being 30.7 (95% confidence interval, 2.5 to 384). There were weaker associations with other aspects of the thermal environment. This suggests a link between HSES and some cases of cot death, supports the suggestion that HSES may be caused by overheating, and reinforces advice that babies should be placed to sleep in such a way that they are less likely to become totally covered.
|
['Brain Diseases', 'Case-Control Studies', 'Female', 'Fever', 'Hot Temperature', 'Humans', 'Infant', 'Logistic Models', 'Male', 'Multivariate Analysis', 'Shock, Hemorrhagic', 'Syndrome']
| 10,490,526
|
[['C10.228.140'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C23.888.119.344'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695.470', 'N06.850.520.830.500.525', 'N06.850.520.830.600.800.450', 'N06.850.520.830.750.450'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['C23.550.414.980', 'C23.550.835.650'], ['C23.550.288.500']]
|
['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]']
| 0
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
The fantastic journey of a bullet: out with a snare.
|
Bullet embolus is a rare complication of penetrating missile trauma. Removal of the bullet previously required surgery. We report the case of a 14-year-old with an hepatic vein bullet embolus following a gunshot wound to the left buttock. A transjugular approach was used to extract the bullet percutaneously with an Amplatzer gooseneck snare.
|
['Adolescent', 'Catheterization', 'Embolectomy', 'Embolism', 'Foreign Bodies', 'Hepatic Veins', 'Humans', 'Jugular Veins', 'Male', 'Wounds, Gunshot']
| 19,795,162
|
[['M01.060.057'], ['E02.148', 'E05.157'], ['E04.100.814.445'], ['C14.907.355.350'], ['C26.392'], ['A07.015.908.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.908.498'], ['C26.986.900']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Diabetes mellitus is a strong, independent risk for atrial fibrillation and flutter in addition to other cardiovascular disease.
|
BACKGROUND: Diabetes mellitus (DM) is a major risk factor for atherosclerosis. There is a controversy in literature about correlation between DM and atrial fibrillation. The goal of this study was to evaluate DM as a risk factor for atrial fibrillation or flutter using a very large database.METHOD: Patient treatment files (PTF) containing discharge diagnoses were utilized using ICD-9 codes of inpatient treatment from Veterans Health Administration Hospitals (VAH). Patients with type II DM (ICD-9 code 250.0) (293,124) discharged from the VAH between 1990 and 2000. Non-matched controls without DM but with hypertension (552,624) were selected from the same PTF. By using multi-variate logistic regressions, the occurrence of atrial fibrillation, atrial flutter, CHF, CAD and LVH was compared.RESULTS: Atrial fibrillations occurred in 43,674 (14.9%) DM patients vs. 57,077 (10.3%) in the control group (p<0.0001). Atrial flutter occurred in 11,852 (4%) of DM patients vs. 13,554 (2.5%) of the control group (p<0.0001). Using multi-variant analysis, DM remained independently associated with atrial fibrillation with an OR of 2.13, (95% CI: 2.10 to 2.16; p<0.0001) and flutter (OR 2.20, CI: 2.15 to 2.26; p<0.0001). Furthermore, CHF (OR 3.12, CI: 3.09 to 3.16; p<0.0001), LVH (OR 1.85, CI: 1.77 to 1.92; p<0.0001) and CAD (OR 2.39, CI: 2.34 to 2.44; p<0.0001) were also independently associated with DM.CONCLUSION: This is the first large-scale study finding DM as a strong, independent risk for the occurrence of atrial fibrillation and flutter and other cardiovascular disease.
|
['Aged', 'Atrial Fibrillation', 'Atrial Flutter', 'Case-Control Studies', 'Coronary Artery Disease', 'Diabetes Complications', 'Female', 'Heart Failure', 'Humans', 'Hypertrophy, Left Ventricular', 'Male', 'Middle Aged', 'Retrospective Studies', 'Risk Factors']
| 16,274,775
|
[['M01.060.116.100'], ['C14.280.067.198', 'C23.550.073.198'], ['C14.280.067.248', 'C23.550.073.248'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['C19.246.099'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.195.400', 'C23.300.775.250.400'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725']]
|
['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]']
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state.
|
(+)-(3S,4R)-4-(N-Acetyl-N-benzyloxyamino)-6-cyano-3,4-dihydro-2,2- dimethyl- 2H-1-benzopyran-3-ol (Y-27152) is a new K+ channel opener with a long duration of action and less tachycardia. In this study, Y-27152 was compared with a K+ channel opener lemakalim and a Ca++ channel blocker nifedipine for antihypertensive activity in conscious spontaneously hypertensive rats (SHR) and two-kidney, one-clip renal hypertensive dogs (RHD). In conscious SHR, Y-27152 (0.1-1 mg/kg, p.o.) produced long-lasting dose-related decreases in systolic blood pressure. At 1 mg/kg, the maximum response occurred 5 to 7 hr after dosing, and 24 hr later, the pressure was still significantly reduced. Heart rate was not changed by these doses of Y-27152, whereas equihypotensive doses of lemakalim or nifedipine were strongly tachycardic. The cardiovascular effects of Y-27152 were antagonized by glibenclamide (20 mg/kg, i.v.). In conscious unrestrained RHD, Y-27152 at doses of 0.01, 0.03 and 0.1 mg/kg lowered blood pressure with a slow onset and long duration of action and had only a minimal effect on heart rate, whereas both lemakalim and nifedipine reduced blood pressure and markedly increased heart rate. No tolerance to the antihypertensive effect of Y-27152 (0.1 mg/kg) occurred during an 8-week repeated daily dosing to RHD and plasma renin activity, and aldosterone levels were not elevated during this period. In rat aortic rings contracted with 20 mM KCl, Y-27152 did not modify the tension; however, its desbenzyl form (Y-26763) produced vasorelaxation, and this effect was antagonized competitively by glibenclamide.(ABSTRACT TRUNCATED AT 250 WORDS)
|
['Administration, Oral', 'Animals', 'Antihypertensive Agents', 'Benzopyrans', 'Blood Pressure', 'Cromakalim', 'Dogs', 'Female', 'Heart Rate', 'Hypertension, Renal', 'Male', 'Muscle, Smooth, Vascular', 'Nifedipine', 'Potassium Channels', 'Prodrugs', 'Pyrroles', 'Rats', 'Rats, Inbred SHR', 'Tachycardia']
| 1,578,381
|
[['E02.319.267.100'], ['B01.050'], ['D27.505.954.411.162'], ['D03.383.663.283', 'D03.633.100.150'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D03.383.129.578.150', 'D03.383.663.283.455', 'D03.633.100.150.455'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.600.875.500', 'G09.330.380.500'], ['C12.777.419.331', 'C13.351.968.419.331', 'C14.907.489.631'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.467.491'], ['D03.383.725.203.540'], ['D12.776.157.530.400.600', 'D12.776.543.550.450.750', 'D12.776.543.585.400.750'], ['D26.675'], ['D03.383.129.578'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.300', 'B01.050.150.900.649.313.992.635.505.700.400.300'], ['C14.280.067.845', 'C14.280.123.875', 'C23.550.073.845']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Elevated B-type natriuretic peptide levels in patients undergoing coronary stenting.
|
BACKGROUND: Release of B-type natriuretic peptide (BNP) may be triggered by tissue hypoxia even in the absence of left ventricular (LV) dysfunction, generating interest in studying changes in levels following percutaneous coronary intervention (PCI). Though the prognostic role of natriuretic peptides following elective PCI has been documented, most studies only assessed single pre-procedural levels. Previous studies assessing BNP rise following balloon angioplasty or coronary stenting have reported conflicting results; most of these studies excluded patients with recent acute coronary syndrome (ACS).RESULTS: We studied the changes in BNP following coronary stenting in 100 patients across the entire spectrum of ACS and observed a significant rise in BNP following stenting. Baseline BNP levels > 100 pg/ml were observed in 31% of patients; following PCI, 45% of patients were noted to have BNP > 100 pg/ml. In patients with baseline BNP < 100 pg/ml, 20% had post-procedure BNP levels > 100 pg/ml. Post-PCI BNP levels were significantly higher in patients with recent ACS (versus those with stable angina), those with LV dysfunction, high baseline troponin I, visible angiographic thrombus and those with post-PCI TIMI 1-2 flow. Patients with post-PCI BNP levels > 100 pg/ml had a trend toward more frequent occurrence of TIMI no reflow following PCI (9.3 versus 1.7%; p = 0.07).CONCLUSION: Recent ACS, raised basal troponin, LV dysfunction, and presence of angiographic thrombus were all associated with high baseline and post-PCI BNP levels. Though recent ACS was the strongest predictor of elevated BNP levels, BNP levels rose following PCI even in patients with chronic stable angina.
|
['Adult', 'Aged', 'Aged, 80 and over', 'Angioplasty, Balloon, Coronary', 'Coronary Artery Disease', 'Female', 'Humans', 'Male', 'Middle Aged', 'Natriuretic Peptide, Brain', 'Stents']
| 21,646,650
|
[['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D06.472.699.584.625', 'D12.644.548.585.625', 'D12.776.631.590'], ['E07.695.750']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]']
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Determinants of antenatal care utilisation in sub-Saharan Africa: a systematic review.
|
OBJECTIVES: To identify the determinants of antenatal care (ANC) utilisation in sub-Saharan Africa.DESIGN: Systematic review.DATA SOURCES: Databases searched were PubMed, OVID, EMBASE, CINAHL and Web of Science.ELIGIBILITY CRITERIA: Primary studies reporting on determinants of ANC utilisation following multivariate analysis, conducted in sub-Saharan Africa and published in English language between 2008 and 2018.DATA EXTRACTION AND SYNTHESIS: A data extraction form was used to extract the following information: name of first author, year of publication, study location, study design, study subjects, sample size and determinants. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist for reporting a systematic review or meta-analysis protocol was used to guide the screening and eligibility of the studies. The Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies was used to assess the quality of the studies while the Andersen framework was used to report findings.RESULTS: 74 studies that met the inclusion criteria were fully assessed. Most studies identified socioeconomic status, urban residence, older/increasing age, low parity, being educated and having an educated partner, being employed, being married and Christian religion as predictors of ANC attendance and timeliness. Awareness of danger signs, timing and adequate number of antenatal visits, exposure to mass media and good attitude towards ANC utilisation made attendance and initiation of ANC in first trimester more likely. Having an unplanned pregnancy, previous pregnancy complications, poor autonomy, lack of husband's support, increased distance to health facility, not having health insurance and high cost of services negatively impacted the overall uptake, timing and frequency of antenatal visits.CONCLUSION: A variety of predisposing, enabling and need factors affect ANC utilisation in sub-Saharan Africa. Intersectoral collaboration to promote female education and empowerment, improve geographical access and strengthened implementation of ANC policies with active community participation are recommended.
|
['Africa South of the Sahara', 'Female', 'Health Services Accessibility', 'Health Services Needs and Demand', 'Humans', 'Patient Acceptance of Health Care', 'Pregnancy', 'Prenatal Care', 'Socioeconomic Factors']
| 31,594,900
|
[['Z01.058.290'], ['N04.590.374.350', 'N05.300.430'], ['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500', 'F01.145.488.887.500', 'N05.300.150.800.500'], ['G08.686.784.769'], ['E02.760.786', 'N02.421.143.620.704', 'N02.421.585.786'], ['I01.880.853.996', 'N01.824']]
|
['Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]']
| 0
| 1
| 0
| 0
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 1
| 1
|
Possible salmonella osteomyelitis of spine following laser disc decompression.
|
We report a case of chronic discitis and vertebral osteomyelitis that we believe was caused by Salmonella typhimurium following laser decompression of the L4/5 disc for symptomatic disc protrusion in a 50-year-old Asian man. The infection was successfully treated with intravenous ceftriaxone combined with oral ciprofloxacin. We believe this to be the only report of such a complication following this procedure, which is generally without infective complications.
|
['Discitis', 'Diskectomy, Percutaneous', 'Humans', 'Intervertebral Disc Displacement', 'Laser Therapy', 'Lumbar Vertebrae', 'Male', 'Middle Aged', 'Osteomyelitis', 'Postoperative Complications', 'Salmonella Infections', 'Salmonella typhimurium', 'Spinal Diseases']
| 9,883,962
|
[['C01.160.762.301', 'C05.116.165.762.301', 'C05.116.900.853.500'], ['E02.718.444.200', 'E04.188.350.200', 'E04.555.200.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.900.307', 'C23.300.707.952'], ['E02.594', 'E04.014.520'], ['A02.835.232.834.519'], ['M01.060.116.630'], ['C01.160.495', 'C05.116.165.495'], ['C23.550.767'], ['C01.150.252.400.310.821'], ['B03.440.450.425.800.200.825', 'B03.660.250.150.710.160.760'], ['C05.116.900']]
|
['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Potential fate of ingested Lactobacillus plantarum and its occurrence in human feces.
|
Lactobacillus plantarum has been used in human clinical trials to promote beneficial effects in the immune system, to alleviate intestinal disorders, and to reduce the risk of cardiovascular disease. It is also involved in many fermentation processes in the food industry. However, information on the fate of ingested L. plantarum is limited. In this study, 61 subjects received daily doses of fermented milk containing 2 ? 10(11) cells of L. plantarum Lp115 for different periods of time. The target microorganism was monitored in the fecal microbiota via quantitative PCR (qPCR). L. plantarum was detected and quantified in all of the subjects during the ingestion periods. The differences between the L. plantarum levels at time zero and during all the different ingestion periods were statistically significant (P = 0.001). However, at 15 and 45 days after discontinuing supplementation, the number of lactobacilli was reduced to the baseline level (those at time zero). A longer period with L. plantarum in the diet did not result in increased levels of this bacterium in the stool, based on postconsumption evaluations (P = 0.001). The qPCR method was specific and sensitive for L. plantarum quantification in such a complex microbial environment as the gastrointestinal tract.
|
['Bacterial Load', 'Diet', 'Feces', 'Humans', 'Lactobacillus plantarum', 'Real-Time Polymerase Chain Reaction']
| 24,271,176
|
[['E01.370.225.875.150.115', 'E01.370.225.875.220.115', 'E05.200.875.150.115', 'E05.200.875.220.115', 'G06.099.100'], ['G07.203.650.240'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.353.750.450.475.612', 'B03.510.460.400.410.475.475.612', 'B03.510.550.450.475.612'], ['E05.393.620.500.706']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]']
| 1
| 1
| 0
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Comparison of mean frequency and median frequency in evaluating muscle fiber type selection in varying gait speed across healthy young adult individuals.
|
The preferential slow and fast twitches fiber involvement in varying gait speed has not been thoroughly investigated. Attempt to classify fiber type in changing speed should be closely investigated and scrutinized as the histochemical-related experiments are cumbersome and time consuming. In addressing this issue, electromyography (EMG) is utilized to extract the muscle fiber type features by altering the muscle fatigue indices, namely mean frequency (MNF) and median frequency (MDF). Recently, there are no universal indices to determine the muscle type. In this paper, the MNF and MDF are employed in discovering the muscle type variation as the speed changes. Besides drawing the potential of MNF and MDF in unveiling the muscle type, both the parameters are applied to investigate the muscles that are recruited and which muscle type are involved as the gait velocity changes. In this study, six healthy and young participants are recruited, whereby the EMG sensors are placed on twelve lower extremity muscles. The EMG signals are then processed via Matlab software to deduce MNF and MDF. The MNF and MDF are determined from every of the phase gait, namely stance and swing. From the results obtained, it reveals that the superiority of the MNF over the MDF in determining and interpreting the muscle recruitment in both gait phases as the speed increases. The MNF, moreover, is able to show an apparent difference in muscle type selection compared to MDF. Interestingly, it is discovered that as the speed increases from slow to fast, the MNF decreases, which indicates that more muscle fiber type I is recruited. Contrarily, the MNF increases as the speed intensity decreases, which indicates that the distribution of muscle type II is prominent.
|
['Electromyography', 'Gait', 'Humans', 'Muscle Fatigue', 'Muscle Fibers, Skeletal', 'Walking Speed', 'Young Adult']
| 28,268,659
|
[['E01.370.405.255', 'E01.370.530.255'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.550'], ['A10.690.552.500.500', 'A11.620.249'], ['E01.370.600.250.500', 'G11.427.410.568.900.750.500'], ['M01.060.116.815']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]']
| 1
| 1
| 0
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Effects of SR 48692, a selective non-peptide neurotensin receptor antagonist, on two dopamine-dependent behavioural responses in mice and rats.
|
One major mechanism underlying the central action of neurotensin is an interaction with the function of dopamine (DA)-containing neurons. In addition, direct or indirect DA agonists have been reported to promote neurotensin release. We have found that SR 48692, a non-peptide neurotensin receptor antagonist (0.04-0.64 mg/kg orally), antagonizes (50-65%) yawning induced by apomorphine (0.07 mg/kg SC) or bromocriptine (2 mg/kg IP) in rats, and turning behaviour induced by intrastriatal injection of apomorphine (0.25 micrograms), (+) SKF 38393 (0.1 micrograms), bromocriptine (0.01 ng) or (+) amphetamine (10 micrograms) in mice. Other apomorphine-induced effects in mice and rats such as climbing, hypothermia, hypo- and hyper-locomotion, penile erections and stereotypies were not significantly modified by SR 48692. Taken together, these data suggest that neurotensin may play a permissive role in the expression of some but not all behavioural responses to DA receptor stimulation.
|
['2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine', 'Animals', 'Apomorphine', 'Behavior, Animal', 'Bromocriptine', 'Dopamine', 'Dose-Response Relationship, Drug', 'Female', 'Male', 'Mice', 'Motor Activity', 'Penile Erection', 'Pyrazoles', 'Quinolines', 'Rats', 'Rats, Wistar', 'Receptors, Neurotensin', 'Stereotyped Behavior', 'Yawning']
| 7,862,953
|
[['D03.633.100.079.838'], ['B01.050'], ['D03.132.098.038.290', 'D03.633.100.531.085.030.290', 'D03.633.400.095.290'], ['F01.145.113'], ['D03.132.327.412.100', 'D03.633.400.439.131', 'D03.633.400.562.100'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['F01.145.632', 'G11.427.410.698'], ['G08.686.784.717'], ['D03.383.129.539'], ['D03.633.100.810'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D12.776.543.750.695.550', 'D12.776.543.750.720.600.560', 'D12.776.543.750.750.555.560'], ['F01.145.896'], ['G09.772.982']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]']
| 0
| 1
| 0
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Spatially- and temporally-restricted expression of meltrin alpha (ADAM12) and beta (ADAM19) in mouse embryo.
|
The cloning of the full-length cDNA encoding meltrin beta (ADAM19), one of the metalloprotease-disintegrins expressed in mouse myogenic cells, revealed that the meltrin beta gene encodes a membrane protein closely related to meltrin alpha (ADAM12) which participates in myotube formation in vitro. To delineate the functions of meltrin alpha and beta, we examined the expression patterns of their transcripts during embryogenesis. The meltrin alpha gene is activated in condensed mesenchymal cells that give rise to skeletal muscle, bones and visceral organs. Meltrin beta mRNA, in contrast, is markedly expressed in craniofacial and dorsal root ganglia and ventral horns of the spinal cord, where peripheral neuronal cell lineages differentiate. Heart, skeletal muscle, intestine and lung also express meltrin beta mRNA transiently. Although the meltrin alpha and beta transcripts exhibit distinct expression patterns during embryogenesis, both genes are mainly activated in mesenchymal cells that are derived from both mesoderm and ectoderm.
|
['ADAM Proteins', 'ADAM12 Protein', 'Amino Acid Sequence', 'Animals', 'Cloning, Molecular', 'DNA, Complementary', 'Disintegrins', 'Embryo, Mammalian', 'Gene Expression Regulation, Developmental', 'Membrane Proteins', 'Metalloendopeptidases', 'Metalloproteases', 'Mice', 'Molecular Sequence Data', 'Muscle Proteins', 'RNA, Messenger']
| 9,622,634
|
[['D08.811.277.656.675.374.102', 'D09.400.430.500', 'D12.776.395.033'], ['D08.811.277.656.675.374.102.125', 'D09.400.430.500.125', 'D12.776.395.033.125'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['D12.644.138'], ['A16.254'], ['G05.308.310'], ['D12.776.543'], ['D08.811.277.656.300.480', 'D08.811.277.656.675.374'], ['D08.811.277.656.675'], ['B01.050.150.900.649.313.992.635.505.500'], ['L01.453.245.667'], ['D12.776.210.500'], ['D13.444.735.544']]
|
['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 1
| 0
| 0
| 0
|
[Role of i.v. cholangiography and ultrasonography in preoperative diagnosis before laparoscopic cholecystectomy].
|
In a prospective clinical study the relevance of i.v. cholangiography and ultrasonography for preoperative diagnosis before laparoscopic cholecystectomy was assessed. Imaging of the common bile duct was realized successfully via i.v. cholangiography in 96.3% of all patients. Compared with ERCP, i.v. cholangiography diagnosis proved correct in 91.6% of all cases with pathological depiction of the common bile duct. Ultrasonography offered a sensitivity of 97.8% for assessing the common bile duct diameter. However, the distinction between intraductal concrements and artifacts caused by air superposition may be difficult. I.v. cholangiography is the most sensitive and easy to realize diagnostic technique to identify concrements in the common bile duct. The results of this study indicate that a combined strategy of i.v. cholangiography and ultrasonography may replace ERCP for preoperative diagnosis before laparoscopic cholecystectomy, if there is a sufficient depiction of the common bile duct and without concrements in it.
|
['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Cholangiography', 'Cholangiopancreatography, Endoscopic Retrograde', 'Cholecystectomy, Laparoscopic', 'Common Bile Duct', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Ultrasonography']
| 8,054,545
|
[['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.350.700.715.200', 'E01.370.372.200'], ['E01.370.350.700.715.200.200', 'E01.370.372.200.200', 'E01.370.372.250.200', 'E01.370.388.250.250.160', 'E04.210.240.160', 'E04.502.250.250.160'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['A03.159.183.079.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.350.850']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]']
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
The highly conserved glycan at asparagine 260 of HIV-1 gp120 is indispensable for viral entry.
|
Carbohydrate-binding agents bind to the N-glycans of HIV-1 envelope gp120 and prevent viral entry. Carbohydrate-binding agents can select for mutant viruses with deleted envelope glycans. Not all glycosylation motifs are mutated to the same extent. Site-directed mutagenesis revealed that deletions destroying the highly conserved (260)NGS(262) glycosylation motif resulted in non-infectious virus particles. We observed a significant lower CD4 binding in the case of the N260Q mutant gp120 virus strains, caused by a strikingly lower expression of gp120 and gp41 in the virus particle. In addition, the mutant N260Q HIV-1 envelope expressed in 293T cells was unable to form syncytia in co-cultures with U87.CD4.CXCR4.CCR5 cells, due to the lower expression of envelope protein on the surface of the transfected 293T cells. The detrimental consequence of this N-glycan deletion on virus infectivity could not be compensated for by the creation of novel glycosylation sites near this amino acid, leaving this uncovered envelope epitope susceptible to neutralizing antibody binding. Thus, the Asn-260 glycan in the gp120 envelope of HIV-1 represents a hot spot for targeting suicidal drugs or antibodies in a therapeutic effort to efficiently neutralize a broad array of virus strains.
|
['Asparagine', 'Cell Line', 'Coculture Techniques', 'HIV Envelope Protein gp120', 'HIV Envelope Protein gp41', 'HIV-1', 'Humans', 'Mutagenesis, Site-Directed', 'Mutation', 'Polysaccharides', 'Virion']
| 22,006,924
|
[['D12.125.068.060', 'D12.125.095.165', 'D12.125.154.049'], ['A11.251.210'], ['E05.481.500.374'], ['D12.776.964.775.325.164.249', 'D12.776.964.775.562.500.500', 'D12.776.964.970.880.325.164.249', 'D23.050.327.520.350'], ['D12.776.543.512.500.330', 'D12.776.964.775.325.164.200', 'D12.776.964.775.562.500.200', 'D12.776.964.970.880.325.164.200', 'D12.776.964.970.880.910.330', 'D23.050.327.520.330'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.420.601.575'], ['G05.365.590'], ['D09.698'], ['A21.249']]
|
['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
The correlation in antepartum fetal test between full fetal biophysical profile (FBP) and rapid biophysical profile (rBPP).
|
OBJECTIVE: To determine the correlation between the rapid biophysical profile (rBPP), the combination of amniotic fluid index (AFI), and sound-provoked fetal movement (SPFM) detected by ultrasound, and the full biophysical profile (FBP) in terms of abnormal and normal result.MATERIAL AND METHOD: A prospective study was performed in 200 singleton pregnancies with no fetal anomalies between 30-42 weeks of gestation indicated for non-stress test (NST). All participants received both the standard (FBP) and the new rBPP examinations. Abnormal fetal test was defined as having a score of < or = 6 for FBP or < or = 2 for rBPP. The main outcome measurement was Spearman's correlation coefficient (r) between both examinations.RESULTS: The incidences of the abnormal tests were 1.5% and 6.0% in FBP and rBPP, respectively. The data showed a positive correlation between the two tests (r(s) = 0.67; p < 0.01). Regarding the operative time, FBP assessment was 25.56 +/- 8.75 times longer than rBPP. The number of abnormal NST was remarked at 1.5% while oligohydramnios and abnormal SPFM were detected at 5% and 2%, respectively. Compared to the standard NST, rBPP test was significantly superior in terms of correlation with FBP (r(s) = 0.67 vs. 0.33) and shorter duration of test (1.21 +/- 0.32 min. vs. 21.65 +/- 5.47).CONCLUSION: The statistically significant positive correlation between rBPP and FBP has been revealed. Due to its simplicity, rapidity, and no need of expensive equipment or experienced interpreter the rBPP may be alternatively used as a primary antepartum fetal test in the overcrowded obstetric center or when fetal surveillance tests are limited.
|
['Acoustic Stimulation', 'Adult', 'Amniotic Fluid', 'Female', 'Fetal Distress', 'Fetal Monitoring', 'Fetal Movement', 'Fetus', 'Gestational Age', 'Humans', 'Pregnancy', 'Prospective Studies', 'Ultrasonography, Prenatal', 'Young Adult']
| 20,649,052
|
[['E02.037', 'E02.190.888.030', 'E05.723.136'], ['M01.060.116'], ['A12.098', 'A16.378.149'], ['C23.888.380'], ['E01.370.378.230', 'E01.370.520.230'], ['G07.345.500.325.235.374', 'G08.686.784.170.157.374'], ['A16.378'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.350.850.865', 'E01.370.378.630.865'], ['M01.060.116.815']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]']
| 1
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme.
|
S-Nitrosoglutathione and the dinitrosyl-diglutathionyl iron complex are involved in the storage and transport of NO in biological systems. Their interactions with the human glutathione transferase P1-1 may reveal an additional physiological role for this enzyme. In the absence of GSH, S-nitrosoglutathione causes rapid and stable S-nitrosylation of both the Cys(47) and Cys(101) residues. Ion spray ionization-mass spectrometry ruled out the possibility of S-glutathionylation and confirms the occurrence of a poly-S-nitrosylation in GST P1-1. S-Nitrosylation of Cys(47) lowers the affinity 10-fold for GSH, but this negative effect is minimized by a half-site reactivity mechanism that protects one Cys(47)/dimer from nitrosylation. Thus, glutathione transferase P1-1, retaining most of its original activity, may act as a NO carrier protein when GSH depletion occurs in the cell. The dinitrosyl-diglutathionyl iron complex, which is formed by S-nitrosoglutathione decomposition in the presence of physiological concentrations of GSH and traces of ferrous ions, binds with extraordinary affinity to one active site of this dimeric enzyme (K(i) < 10(-12) m) and triggers negative cooperativity in the vacant subunit (K(i) = 10(-9) m). The complex bound to the enzyme is stable for hours, whereas in the free form and at low concentrations, its life time is only a few minutes. ESR and molecular modeling studies provide a reasonable explanation of this strong interaction, suggesting that Tyr(7) and enzyme-bound GSH could be involved in the coordination of the iron atom. All of the observed findings suggest that glutathione transferase P1-1, by means of an intersubunit communication, may act as a NO carrier under different cellular conditions while maintaining its well known detoxificating activity toward dangerous compounds.
|
['Binding, Competitive', 'Electron Spin Resonance Spectroscopy', 'Glutathione', 'Glutathione S-Transferase pi', 'Glutathione Transferase', 'Humans', 'Iron', 'Isoenzymes', 'Mass Spectrometry', 'Nitric Oxide', 'Nitrogen Oxides', 'Protein Binding', 'S-Nitrosoglutathione', 'Serum Albumin']
| 11,533,048
|
[['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['E05.196.867.519.274'], ['D12.644.456.448'], ['D08.811.913.225.500.500'], ['D08.811.913.225.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D08.811.348', 'D12.776.800.300'], ['E05.196.566'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['D01.362.635', 'D01.625.550', 'D01.650.550.587'], ['G02.111.679', 'G03.808'], ['D02.654.846.500.249', 'D02.886.489.650.750', 'D12.644.456.448.750'], ['D12.776.034.841', 'D12.776.124.727']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]']
| 0
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Understanding symptom experiences of muscle tightness from patients' and clinicians' perspectives.
|
AIMS AND OBJECTIVES: The purpose of this study was to determine how patients' symptom experiences of muscle tightness correlate with examiner assessments. To address this question, we (1) obtained the vocabularies used by patients and examiners to describe muscle tightness, (2) correlated patient- reported Visual Analog Scale ratings for locations of muscle tightness on a body diagram and (3) explored the similarities and differences between patient and examiner evaluation of muscle tightness analytically and graphically.BACKGROUND: Symptoms of muscle tightness are common complaints that occur due to musculoskeletal and neuromusculoskeletal injuries. Terms such as muscle tightness are often intermingled with other conditions including muscle tension, muscle spasticity and muscle rigidity. Discrepancies between patients and clinicians understanding of similar symptoms have been reported in the literature.DESIGN: A concurrent exploratory mixed methods design was used.METHOD: Fifty-seven participants (six physical therapists, 51 patients) participated. Participants provided semi-structured interviews, ratings through Visual Analog Scale and concurrently provided the words used to describe muscle tightness. Patients also provided the location of muscle tightness on a body diagram. Content analysis and hierarchical linear modelling were used for data analysis.RESULTS: The patients' vocabularies contained more sensory and pain experiences when compared to the clinicians' vocabularies. Examiners and patients ratings were variable (standard deviation >20) and contained discrepancies. Stress played a role in the symptom experience of muscle tightness. Examiners tended to focus on patients' chief complaints, while patients reported their symptoms from a whole-body perspective.CONCLUSIONS: Symptom experiences of muscle tightness can occur with or without pain. Use of complementary therapy and development of an objective tool that accounts for patients' sensory experiences is warranted.RELEVANCE TO CLINICAL PRACTICE: Findings from this study indicate that in addition to all other available treatments options, nurses must also educate patients about correct posture alignment, breathing exercises and stress management.
|
['Adult', 'Aged', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Middle Aged', 'Muscle Tonus', 'Pain Measurement', 'Professional-Patient Relations', 'Prospective Studies', 'Terminology as Topic', 'Young Adult']
| 27,533,094
|
[['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['M01.060.116.630'], ['G11.427.565'], ['E01.370.600.550.324'], ['F01.829.401.650', 'N05.300.660'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['L01.559.598.400'], ['M01.060.116.815']]
|
['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]']
| 0
| 1
| 0
| 0
| 1
| 1
| 1
| 0
| 0
| 0
| 1
| 1
| 1
| 0
|
Pain relief after major abdominal surgery: a double-blind controlled comparison of sublingual buprenorphine, intramuscular buprenorphine, and intramuscular meperidine.
|
In a double-blind randomized study of three groups of 18 patients scheduled for major abdominal surgery the efficacy and side effects of sublingual buprenorphine were tested and compared to intramuscular meperidine and buprenorphine. Single doses of either 75 mg of meperidine, 0.4 mg of sublingual buprenorphine, or 0.3 mg of intramuscular buprenorphine were used. Patients given buprenorphine as sublingual tablets were significantly more conscious in the immediate postoperative period (Glasgow Coma Scale) than when given buprenorphine or meperidine intramuscularly. Median pain intensity differences (PID) showed equal pain relief, whereas the summarized pain intensity differences (SPID) were significantly higher in the intramuscular buprenorphine group compared to the meperidine group. Three cases of respiratory acidosis in the meperidine group required IPPV treatment, and one case in the intramuscular buprenorphine group required treatment. Sedation and nausea were the most common side effects in all three groups. We conclude that sublingual buprenorphine is useful for relief of postoperative pain and exhibited administrative advantages, when the patients were able to cooperate.
|
['Abdomen', 'Acidosis, Respiratory', 'Adolescent', 'Adult', 'Buprenorphine', 'Clinical Trials as Topic', 'Double-Blind Method', 'Humans', 'Injections, Intramuscular', 'Meperidine', 'Middle Aged', 'Pain, Postoperative']
| 3,544,957
|
[['A01.923.047'], ['C08.618.846.093', 'C18.452.076.176.310'], ['M01.060.057'], ['M01.060.116'], ['D03.132.577.249.150', 'D03.605.497.150', 'D03.633.400.686.150', 'D04.615.723.795.150'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.460'], ['D03.066.399.450', 'D03.383.621.349.450'], ['M01.060.116.630'], ['C23.550.767.700', 'C23.888.592.612.832']]
|
['Anatomy [A]', 'Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]']
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Osteoclast-like giant cell tumor of the renal pelvis associated with urothelial carcinoma: computed tomography, gross, and histologic appearance.
|
Osteoclastoma-like giant cell tumor of the renal pelvis, similar to the entity more commonly occurring in bone, is very rare, having been reported in twelve previous cases to our knowledge. This is the first report of this entity, to our knowledge, to include its cross-sectional imaging appearance. A hyperdense area within the lesion on non-contrast CT may correspond with extensive hemorrhagic content of the lesion identified histologically. As in most prior cases, an adjacent smaller urothelial carcinoma of the renal pelvis was also identified. In the limited reported cases, this entity has exhibited highly aggressive behavior with poor prognosis.
|
['Carcinoma', 'Female', 'Giant Cell Tumors', 'Humans', 'Kidney Neoplasms', 'Kidney Pelvis', 'Middle Aged', 'Neoplasms, Multiple Primary', 'Osteoclasts', 'Tomography, X-Ray Computed', 'Urothelium']
| 21,458,035
|
[['C04.557.470.200'], ['C04.557.450.565.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['A05.810.453.537'], ['M01.060.116.630'], ['C04.651'], ['A11.329.372.700', 'A11.627.482.700'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['A10.272.850']]
|
['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Can fetal adrenal artery Doppler velocimetry predict delivery date in pregnant women with spontaneous preterm birth?
|
AIM: To assess the accuracy of delivery date predictions made using fetal adrenal artery Doppler velocimetry in pregnant women with spontaneous preterm birth (PB) and to compare these predictions with cervical length (CL) measurements.Material and methods: A prospective study was performed with 51 pregnant women whose gestational lengths were between 24 and 36 weeks. The main outcome was the time between the Doppler velocimetry examination and delivery, categorized as delivery within 7 days or 7 days later after the examination. A receiver operating characteristics curve was performed to define the cutoffs among deliveries within 7 days for fetal adrenal artery Doppler velocimetry parameters and CL measurements.RESULTS: The incidence of delivery within 7 days was 37.3%, with a statistically significant difference for the pulsatility index (PI; p=0.045) and resistance index (RI; p=0.030) of the fetal adrenal artery. The best cutoff values of PI and RI for predicting deliveries within 7 days were 1.65 and 0.78, respectively. The sensitivity and specificity of PI, RI, and CL (20 mm) were 73.7% (95% CI: 51.9-95.5) and 56.3% (95% CI: 38.1-74.4); 68.4% (95% CI: 45.4-91.4) and 62.5% (95% CI: 44.8-80.2); and 76.5% (95% CI: 54.0-99.0) and 78.1% (95%: CI 71.1-97.7), respectively.CONCLUSION: Fetal adrenal artery Doppler velocimetry can predict delivery within 7 days among pregnant women in cases of spontaneous PB and this prediction is similar to the predictions made using CL measurements.
|
['Adrenal Glands', 'Adult', 'Arteries', 'Female', 'Gestational Age', 'Humans', 'Pregnancy', 'Premature Birth', 'Prospective Studies', 'Reproducibility of Results', 'Rheology', 'Sensitivity and Specificity', 'Ultrasonography, Doppler', 'Young Adult']
| 28,845,496
|
[['A06.300.071'], ['M01.060.116'], ['A07.015.114'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['C13.703.420.491.500'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.830', 'H01.671.808'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['E01.370.350.850.850'], ['M01.060.116.815']]
|
['Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]']
| 1
| 1
| 1
| 0
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 1
| 1
| 0
|
Redundant pacing in a child.
|
A 4-year-old boy with congenital complete atrioventricular block (CCAVB) and pacemaker (PM) dependency, received a redundant pacemaker. Two separate leads were implanted in the right ventricle, and connected to a dual chamber PM. The two pacing channels were both programmed so that each lead could compensate for the other in case of threshold elevation. The follow-up was uneventful despite exit block on one of the leads.
|
['Cardiac Pacing, Artificial', 'Child, Preschool', 'Heart Block', 'Humans', 'Male']
| 15,305,970
|
[['E02.331.200'], ['M01.060.406.448'], ['C14.280.067.558', 'C14.280.123.500', 'C23.550.073.425'], ['B01.050.150.900.649.313.988.400.112.400.400']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]']
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
[Eccrine adenocarcinoma in a patient with familial breast carcinoma].
|
A 67-year-old patient developed a subcutaneous, non-tender nodule in her left groin over a period of about seven years. The patient underwent surgery and 4 procedures were required to obtain complete excision. The histopathologic findings showed eccrine adenocarcinoma, a member of the heterogeneous group of sweat gland tumors which occur primarily in adults with a peak of 50-60 years of age. Sweat gland carcinomas are extremely rare neoplasms of the skin and exhibit a slow growth rate with a rather high local recurrence rate. The tumor has a disposition to metastasize and shows a poor response rate to adjuvant therapy regimens. Therefore wide, deep surgical excision with an excision margin of 2-3 cm is the treatment of choice. Nevertheless there are some case reports on successful therapy of a metastasized sweat gland carcinoma with 5-fluorouracil and tamoxifen. Here further studies are needed to achieve a better survival rate for patients with metastatic disease.
|
['Adenocarcinoma', 'Aged', 'Analgesics', 'Eccrine Glands', 'Female', 'Humans', 'Sweat Gland Neoplasms', 'Tamoxifen']
| 18,931,983
|
[['C04.557.470.200.025'], ['M01.060.116.100'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['A10.336.899.480', 'A17.815.830.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.805.776', 'C17.800.882.743', 'C17.800.946.743'], ['D02.455.426.559.389.150.700.900']]
|
['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]']
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
[Transverse study on sex behavior associated with HIV transmission among homosexual men in Catalonia].
|
In 1993, a cross sectional study was carried out on the sexual behaviour of a sample of homosexual men recruited in saunas, sex shops and a gay community-beased organisation of Catalonia. A total of 551 men with an average age of 34 years and a high educational level sent in an anonymous questionnaire. In the previous 6 months the mean number of male sexual partners was 6 and for penetrative partners 3. In the previous month, 94% had had oral sex (22% with ejaculation) and 76% anal intercourse (38% without a condom and 21% with ejaculation). During sex, 51% used alcohol, 34% nitrite inhalants, 20% hashish and 10% cocaine, 61% had had the HIV test, with a self-reported HIV prevalence of 21%. 86% stated that they knew of one or more people infected by HIV or with AIDS. The high percentage of men who had unprotected anal intercourse and the high self-reported HIV prevalence highlights the need to increase efforts in AIDS prevention and research in this group. Monitoring HIV associated sexual behaviours provides valuable indicators of the evolution of the epidemic, useful for designing and evaluating preventive interventions.
|
['Adolescent', 'Adult', 'Condoms', 'Cross-Sectional Studies', 'HIV Infections', 'Homosexuality, Male', 'Humans', 'Male', 'Middle Aged', 'Sexual Behavior', 'Spain', 'Substance-Related Disorders', 'Surveys and Questionnaires']
| 9,289,481
|
[['M01.060.057'], ['M01.060.116'], ['E07.190.270.150'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['F01.145.802.975.500.600', 'G08.686.867.500.600'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.145.802'], ['Z01.542.846'], ['C25.775', 'F03.900'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]']
| 0
| 1
| 1
| 0
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 1
|
Involvement of lncRNA-1700040D17Rik in Th17 cell differentiation and the pathogenesis of EAE.
|
IL-23/STAT3 signaling pathway is a key process in Th17 cell differentiation, and Th17 cells are closely related to the development of autoimmune diseases. We previously designed and prepared rhIL23R-CHR protein to antagonize endogenous IL-23, showing effectiveness in the treatment of experimental autoimmune encephalomyelitis (EAE) in mice. To further elucidate the mechanism of action, mouse lncRNA microarray was used to screen expression profiles of lncRNAs, and a particular lncRNA, 1700040D17Rik was found to down-regulate in EAE model and its expression was significantly increased after the treatment by rhIL23R-CHR. The function of 1700040D17Rik was revealed to associate with the differentiation of Th17 cells through the regulation of the key transcription factor RORãt. Together, regulation of Th17 cells through lncRNA is responsible for the effects of rhIL23R-CHR to balance the immune responses, and 1700040D17Rik has the potential to serve as a therapeutic target or a biomarker for autoimmune diseases.
|
['Animals', 'Cell Differentiation', 'Cells, Cultured', 'Disease Models, Animal', 'Down-Regulation', 'Encephalomyelitis, Autoimmune, Experimental', 'Female', 'Gene Expression Profiling', 'Humans', 'Interleukin-23', 'Mice', 'Mice, Inbred C57BL', 'Multiple Sclerosis', 'Myelin-Oligodendrocyte Glycoprotein', 'Nuclear Receptor Subfamily 1, Group F, Member 3', 'Oligonucleotide Array Sequence Analysis', 'Peptide Fragments', 'RNA, Long Noncoding', 'STAT3 Transcription Factor', 'Signal Transduction', 'Th17 Cells']
| 28,395,256
|
[['B01.050'], ['G04.152'], ['A11.251'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['C10.114.703.300', 'C10.228.140.695.562.250', 'C10.314.350.250', 'C20.111.258.625.300', 'E05.598.500.500.500'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.759', 'D12.776.467.374.465.759', 'D23.529.374.465.550'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['D12.776.395.550.114.500', 'D12.776.543.550.195.500', 'D12.776.543.620.550', 'D12.776.631.580.530', 'D23.050.422.625'], ['D12.776.260.643.182', 'D12.776.826.209.182'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['D12.644.541'], ['D13.444.735.790.375'], ['D12.644.360.024.342.300', 'D12.776.157.057.186.300', 'D12.776.476.024.430.300', 'D12.776.930.840.300'], ['G02.111.820', 'G04.835'], ['A11.118.637.555.567.550.500.400.915', 'A11.118.637.555.567.569.200.400.915', 'A11.118.637.555.567.569.500.400.915', 'A15.145.229.637.555.567.550.500.400.770', 'A15.145.229.637.555.567.569.200.400.770', 'A15.145.229.637.555.567.569.500.400.770', 'A15.382.490.555.567.550.500.400.915', 'A15.382.490.555.567.569.200.400.915', 'A15.382.490.555.567.569.500.400.915']]
|
['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Pressure support ventilation advisory system provides valid recommendations for setting ventilator.
|
BACKGROUND: Pressure support ventilation (PSV) should be applied so that the inspiratory muscles are unloaded appropriately. We developed a computerized advisory system that assesses the load on the inspiratory muscles to spontaneously inhale, reflected by the automatically and noninvasively measured work of breathing per minute, and tolerance for that load, reflected by spontaneous breathing frequency and tidal volume, in a fuzzy-logic algorithm that provides recommendations for setting PSV. We call this a load and tolerance strategy for determining PSV.METHODS: In a clinical validation study, we compared the recommendations from our PSV advisory system to the recommendations of experienced critical-care Registered Respiratory Therapists (RRTs) for setting PSV in patients with respiratory failure. With 76 adult patients in a university medical center surgical intensive care unit receiving PSV, a combined pressure/flow sensor, positioned between the endotracheal tube and patient Y-piece, sent measurements to the PSV advisory system. We compared the advisory system's recommendations (increase, maintain, or decrease the pressure support) to the RRTs' recommendations at the bedside.RESULTS: There were no significant differences between the RRTs' and the advisory system's recommendations (n = 109) to increase, maintain, or decrease PSV. The RRTs agreed with 91% of the advisory system's recommendations (kappa statistic 0.85, P < .001). The advisory system was very good at predicting the RRTs' pressure support recommendations (r(2) = 0.87, P < .02).CONCLUSIONS: A load and tolerance strategy with a computerized PSV advisory system provided valid recommendations for setting PSV to unload the inspiratory muscles, and the recommendations were essentially the same as the recommendations from experienced critical-care RRTs. The PSV advisory system operates continuously and automatically and may be useful in clinical environments where experts are not always available.
|
['Adult', 'Aged', 'Algorithms', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Positive-Pressure Respiration', 'Predictive Value of Tests', 'Reproducibility of Results', 'Respiratory Insufficiency', 'Respiratory Muscles', 'Therapy, Computer-Assisted', 'Tidal Volume', 'Ventilators, Mechanical', 'Work of Breathing']
| 21,235,833
|
[['M01.060.116'], ['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.041.625.790', 'E02.880.820.790'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['C08.618.846'], ['A02.633.567.900'], ['E02.950', 'L01.313.500.750.100.710'], ['E01.370.386.700.485.750.900.350.750', 'G09.772.850.970.500.700'], ['E07.950'], ['E01.370.386.700.975', 'G09.772.965']]
|
['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]']
| 1
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 1
| 1
| 1
| 0
|
High-density lipoproteins neutralize C-reactive protein proinflammatory activity.
|
BACKGROUND: C-reactive protein (CRP), a well-recognized marker of atherosclerosis, has recently been suggested to have a direct proinflammatory effect. The constitutive expression of low levels of CRP in normal plasma suggests the likelihood that a natural factor exists to neutralize the effect of CRP. This factor(s) has not yet been identified. Method and Results- The proinflammatory effect of CRP was measured by the induction of inflammatory adhesion molecules in human umbilical vein endothelial cells (HUVECs). We show that CRP significantly induced upregulation of adhesion molecules in both protein and mRNA levels. The CRP-induced expression of these inflammatory adhesion molecules was completely suppressed when the cells were preincubated with a physiological concentration (1 mg/mL apolipoprotein A-I) of HDLs derived from human plasma (native HDL) or reconstituted HDL (rHDL) at a very low concentration (0.01 mg/mL apolipoprotein A-I). A novel mechanism of HDL inhibition is likely to operate, because (1) rHDL was 100 times more potent than native HDL, (2) preincubation with HDL and its sustained presence were obligatory, and (3) oxidized 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine was the fundamental active component.CONCLUSIONS: The CRP-induced upregulation of inflammatory adhesion molecules in HUVECs was completely prevented by HDL via their oxidized phospholipid components.
|
['Animals', 'Aorta', 'C-Reactive Protein', 'Cattle', 'Cell Adhesion', 'Cells, Cultured', 'Culture Media, Conditioned', 'E-Selectin', 'Endothelial Cells', 'Gene Expression Regulation', 'Humans', 'Inflammation', 'Intercellular Adhesion Molecule-1', 'Lipoproteins, HDL', 'Liposomes', 'Oxidation-Reduction', 'Phosphatidylcholines', 'RNA, Messenger', 'Recombinant Proteins', 'U937 Cells', 'Umbilical Veins', 'Vascular Cell Adhesion Molecule-1']
| 15,078,800
|
[['B01.050'], ['A07.015.114.056'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['B01.050.150.900.649.313.500.380.271'], ['G04.022'], ['A11.251'], ['D27.720.470.305.250', 'E07.206.250'], ['D12.776.395.550.200.700.300', 'D12.776.503.843.300', 'D12.776.543.550.200.700.300', 'D23.050.301.350.700.300'], ['A11.436.275'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['D12.776.395.550.200.450', 'D12.776.543.550.200.450', 'D23.050.301.350.450'], ['D10.532.432', 'D12.776.521.479'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['G02.700', 'G03.295.531'], ['D10.570.755.375.760.400.800'], ['D13.444.735.544'], ['D12.776.828'], ['A11.251.210.190.880', 'A11.251.860.180.880', 'A11.627.482.665.500', 'A11.627.624.249.500', 'A11.627.635.675.750.500'], ['A07.015.908.670.874', 'A16.378.693.807'], ['D12.776.395.550.200.920', 'D12.776.543.550.200.920', 'D23.050.301.350.920']]
|
['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
|
Different roles of p53 between Epstein-Barr virus-positive and -negative gastric carcinomas of matched histology.
|
To clarify the role of p53 in the development of Epstein-Barr virus (EBV)-associated gastric carcinoma, we examined DNA-ploidy pattern, the immunoreactivity of p53, p21(WAF1) and Ki-67 and the incidence of mitosis and apoptosis in EBV-positive and -negative gastric carcinomas of similar histology: a lace pattern and/or gastric carcinoma with lymphoid stroma. There was no significant difference in DNA-ploidy pattern, Ki-67 index or frequencies of mitosis and apoptosis between the two groups. In deeply invasive tumours (involving the muscularis propria or deeper), p53-positive ones were rare in the EBV-encoded small RNA (EBER)-positive group and very common in the EBER-negative group, while in superficial tumours, around one-half of them were p53-positive in both groups. In p53-positive superficial tumours, p21(WAF1)-positive ones accounted for 80% in the EBER-positive group and were scarce in the EBER-negative group. It is thus possible that p53 immunoreactivity reflects the overexpression of wild-type p53 and the stabilization of mutant p53 in the EBER-positive and -negative groups, respectively. The role of p53 in tumour development seems to be smaller in EBER-positive than in -negative gastric carcinomas.
|
['Adenocarcinoma', 'Adult', 'Aged', 'Apoptosis', 'Cell Division', 'Cyclin-Dependent Kinase Inhibitor p21', 'Cyclins', 'DNA, Neoplasm', 'Epstein-Barr Virus Infections', 'Female', 'Genes, p53', 'Herpesvirus 4, Human', 'Humans', 'Ki-67 Antigen', 'Male', 'Middle Aged', 'Ploidies', 'RNA-Binding Proteins', 'Ribosomal Proteins', 'Stomach Neoplasms', 'Tumor Suppressor Protein p53', 'Tumor Virus Infections']
| 11,956,816
|
[['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['G04.146.954.035'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D12.644.360.225.500', 'D12.776.157.687.250', 'D12.776.167.187.500', 'D12.776.476.225.500', 'D12.776.624.776.355.500', 'D12.776.660.720.250'], ['D12.644.360.262', 'D12.776.167.218', 'D12.776.476.262'], ['D13.444.308.425'], ['C01.925.256.466.313', 'C01.925.928.313'], ['G05.360.340.024.340.375.249.385', 'G05.360.340.024.340.415.400.385'], ['B04.280.210.400.500.450', 'B04.280.382.400.500.400', 'B04.613.204.500.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.660.625.500', 'D23.050.290.500', 'D23.101.140.400'], ['M01.060.116.630'], ['G05.700'], ['D12.776.157.725', 'D12.776.664.962'], ['D12.776.835'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789'], ['D12.776.157.687.650', 'D12.776.260.820', 'D12.776.624.776.775', 'D12.776.660.720.650', 'D12.776.744.845'], ['C01.925.928']]
|
['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]']
| 0
| 1
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Nuchal cord and perinatal outcome.
|
OBJECTIVE: to find out the incidence of nuchal cord at delivery, intrapartum complication and perinatal outcomes in the cases with nuchal cord.MATERIALS AND METHODS: A prospective, cross-sectional, comparative study done at Kathmandu Medical College Teaching Hospital (KMCTH) between March 2006 to September 2006. Total 512 deliveries occurred during this period that were enrolled in the study and were analyzed for presence of nuchal cord at the time of delivery, number of coils whether loose or tight, intrapartum complications and perinatal outcome. The cases with nuchal cord at the time of delivery were taken as study group and the cases without nuchal cord served as control group. Outcome variables between the two groups were compared. Outcome variables used were meconium staining of liquor, rate of instrumental and caesarean delivery, intrapartum fetal heart rate (FHR) irregularities. As a measure of perinatal outcome Apgar score<7 at 1 minute and 5 minutes and incidence of neonatal unit admission was taken.RESULTS: Incidence of nuchal cord at the time of delivery was 22.85%. Incidence of single nuchal cord was highest (18.95%). Intrapartum complications like FHR irregularities and meconium staining of liquor were increased in nuchal cord group but statistically not significant. Instrumental delivery rate was high in nuchal cord group but statistically not significant (0.108). However, caesarean section rate was high in the group without nuchal cord (p=0.029). Apgar score<7 at 1 minute was significantly low in nuchal cord group (p=0.010) but apgar score at 5 minutes and admission to neonatal unit was not more common.CONCLUSION: Nuchal cord is not associated with adverse perinatal outcome.
|
['Adult', 'Cesarean Section', 'Chi-Square Distribution', 'Cross-Sectional Studies', 'Female', 'Humans', 'Infant, Newborn', 'Nepal', 'Nuchal Cord', 'Pregnancy', 'Pregnancy Outcome', 'Prospective Studies', 'Risk Factors']
| 18,604,054
|
[['M01.060.116'], ['E04.520.252.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['Z01.252.245.674'], ['C13.703.413', 'C16.300.790'], ['G08.686.784.769'], ['E01.789.700', 'G08.686.784.769.496'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]']
| 0
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 1
|
Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
|
Neuroblastoma is a cancer of the sympathetic nervous system that accounts for approximately 10% of all pediatric oncology deaths. Here, we report a genome-wide association study of 2,817 neuroblastoma cases and 7,473 controls. We identified two new associations at 6q16, the first within HACE1 (rs4336470; combined P=2.7?10(-11); odds ratio 1.26, 95% confidence interval (CI) 1.18-1.35) and the second within LIN28B (rs17065417; combined P=1.2?10(-8); odds ratio 1.38, 95% CI 1.23-1.54). Expression of LIN28B and let-7 miRNA correlated with rs17065417 genotype in neuroblastoma cell lines, and we observed significant growth inhibition upon depletion of LIN28B, specifically in neuroblastoma cells that were homozygous for the risk allele. Low HACE1 and high LIN28B expression in diagnostic primary neuroblastomas were associated with worse overall survival (P=0.008 and 0.014, respectively). Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression.
|
['Case-Control Studies', 'Cell Line, Tumor', 'Cell Proliferation', 'Chromosomes, Human, Pair 6', 'Cohort Studies', 'DNA-Binding Proteins', 'Gene Expression', 'Gene Frequency', 'Gene Knockdown Techniques', 'Genetic Predisposition to Disease', 'Genome-Wide Association Study', 'Humans', 'Infant', 'Kaplan-Meier Estimate', 'Linkage Disequilibrium', 'Neuroblastoma', 'Oligonucleotide Array Sequence Analysis', 'Polymorphism, Single Nucleotide', 'RNA Interference', 'RNA-Binding Proteins', 'Sequence Analysis, DNA', 'Transcriptome', 'Ubiquitin-Protein Ligases']
| 22,941,191
|
[['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.284.187.520.300.325.330', 'G05.360.162.520.300.325.330'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D12.776.260'], ['G05.297'], ['G05.330'], ['E05.393.335.500'], ['C23.550.291.687.500', 'G05.380.355'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N06.850.520.470.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['G05.348.500'], ['C04.557.465.625.600.590.650.550', 'C04.557.470.670.590.650.550', 'C04.557.580.625.600.590.650.550'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['G05.365.795.598'], ['G05.308.203.374.790'], ['D12.776.157.725', 'D12.776.664.962'], ['E05.393.760.700'], ['G02.111.873.750', 'G05.297.700.750', 'G05.360.920'], ['D08.811.464.938.750']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Common Variants rs3815188 and rs1043994 on Notch3 Gene Confer Susceptibility to Lung Cancer: A Hospital-Based Case-Control Study.
|
The Notch signaling pathway is a mechanism that plays a role in the determination of cell fate during cell development. Signals between neighbor cells are amplified through the Notch receptors. Notch activity is related to general growth stages such as organogenesis and morphogenesis and has effects on cell differentiation, cell proliferation, and apoptosis. Lung cancer associated with degradation of proteins which regulate cellular activities such as cell growth, differentiation, proliferation and apoptosis or the loss of function of proteins due to mutations in the genes which that express these proteins. We aimed to determine the frequency of the Notch3 rs3815188 (C381T) and rs1043994 (G684A) polymorphisms and to investigate whether this gene is associated with genetic predisposition of development of lung cancer. In this study, DNA samples were extracted from the venous blood sample of 200 subjects (100 lung cancer patients and 100 controls). Notch3 rs3815188 (C381T) and rs1043994 (G684A) polymorphisms were determined using the restriction fragment length polymorphism method. A statistically significant difference was found between the patient and control groups for Notch3 gene rs3815188 and rs1043994 polymorphisms when evaluated in terms of genotype (p = 0.002 and p < 0.001, respectively) and allele frequencies (p < 0.05). In conclusion, the rs3815188 variant and rs1043994 variant of the Notch3 gene is associated with lung cancer risk in patients of Turkish origin.
|
['Case-Control Studies', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Humans', 'Lung Neoplasms', 'Polymorphism, Genetic', 'Receptor, Notch3']
| 30,806,291
|
[['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G05.330'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['G05.365.795'], ['D12.776.543.750.725.875', 'D12.776.930.770.875']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]']
| 0
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 0
|
Activation of the c-fos serum-response element by the activated c-Ha-ras protein in a manner independent of protein kinase C and cAMP-dependent protein kinase.
|
12-O-Tetradecanoylphorbol-13-acetate (TPA) activated the c-fos gene enhancer linked to the chloramphenicol acetyltransferase or luciferase reporter gene in the wild type PC-12 cells but not in the variant PC-12 cells that originated from the wild type cells. Transfection of the c-Ha-rasval12 complementary DNA (cDNA) or addition of dibutyryl cAMP to the wild type PC-12 cells as well as to the variant PC-12 cells activated the c-fos gene enhancer. Prolonged treatment of the wild type PC-12 cells with phorbol-12,13-dibutyrate caused down-regulation of protein kinase C. In these cells, TPA did not stimulate the c-fos gene enhancer any more, but transfection of the c-Ha-rasval12 cDNA still stimulated the c-fos gene enhancer to the same extent as induced in the control cells. Transfection of the c-Ha-rasval12 cDNA or addition of TPA to the wild type PC-12 cells stimulated the serum-response element but not the cAMP-response element. Dibutyryl cAMP stimulated both the serum-response element and the cAMP-response element in the wild type PC-12 cells. These results indicate that the c-Ha-rasval12 protein activates the serum-response element, but not the cAMP-response element in the c-fos gene enhancer, and that the signal pathway from the c-Ha-rasval12 protein to the c-fos serum-response element is independent of protein kinase C and cAMP-dependent protein kinase.
|
['Blotting, Western', 'Cells, Cultured', 'Chloramphenicol O-Acetyltransferase', 'DNA', 'Down-Regulation', 'Electrophoresis, Polyacrylamide Gel', 'Gene Expression Regulation, Enzymologic', 'Luciferases', 'Nuclear Proteins', 'Phorbol 12,13-Dibutyrate', 'Plasmids', 'Protein Kinase C', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins p21(ras)', 'Proto-Oncogenes', 'Serum Response Factor', 'Transfection']
| 2,404,011
|
[['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251'], ['D08.811.913.050.134.170'], ['D13.444.308'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['E05.196.401.402', 'E05.301.300.319'], ['G05.308.320'], ['D08.811.682.517', 'D12.776.532.510'], ['D12.776.660'], ['D02.455.849.291.500.510.700'], ['G05.360.600'], ['D08.811.913.696.620.682.700.725'], ['D12.776.624.664.700'], ['D08.811.277.040.330.300.400.500.600', 'D12.644.360.525.500.600', 'D12.776.157.325.515.500.600', 'D12.776.476.525.500.600', 'D12.776.624.664.700.200'], ['G05.360.340.024.340.375.500.791'], ['D12.776.260.400.249.875', 'D12.776.930.397.875'], ['E05.393.350.810', 'G05.728.860']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]']
| 1
| 0
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Pharmacokinetics of continuous once-a-week combination 17â-Estradiol/Low- or high-dose levonorgestrel transdermal delivery systems in postmenopausal women.
|
Two open-label, randomized, two-period, crossover studies were performed to determine the safety, delivery rates, and pharmacokinetic properties of a combination estradiol (E2)/levonorgestrel (LNG) transdermal delivery system (TDS). Study 1 enrolled 24 postmenopausal women who received a single TDS containing 4.4 mg E2 and 1.39 mg of LNG (E2/LNG Low) or E2 0.050 mg/24 hours TDS and 0.090 mg LNG oral tablet. Study 2 enrolled 44 postmenopausal women who received either E2/LNG Low or TDS containing 4.4 mg E2 and 2.75 mg LNG (E2/LNG High) weekly for a period of 4 weeks. E2, estrone (E1), LNG, and sex hormone-binding globulin (SHBG) serum concentrations were determined. Overall, both E2/LNG TDS were well tolerated and had excellent adhesion properties. The average daily delivery for E2/LNG Low was 0.045 mg for E2 and 0.0132 mg for LNG. Following weekly delivery of E2/LNG Low or High for 4 weeks, the combination of E2 with two different strengths of LNG did not alter the pharmacokinetic profile of E2. SHBG, total cholesterol, and triglycerides concentrations significantly decreased compared to baseline. Both E2/LNG Low and High TDSs were well tolerated and provided continuous drug delivery over 7 days supporting the benefits of the transdermal route of administration in optimally delivering hormonal therapy.
|
['Administration, Cutaneous', 'Aged', 'Cross-Over Studies', 'Drug Combinations', 'Drug Delivery Systems', 'Estradiol', 'Estrogens', 'Estrone', 'Ethinyl Estradiol', 'Female', 'Humans', 'Levonorgestrel', 'Middle Aged', 'Postmenopause', 'Sex Hormone-Binding Globulin']
| 24,474,034
|
[['E02.319.267.120.060'], ['M01.060.116.100'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['D26.310'], ['E02.319.300'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D27.505.696.399.472.277'], ['D04.210.500.365.415.414', 'D04.210.500.578.502.497', 'D06.472.040.502.497', 'D06.472.334.851.437.996'], ['D04.210.500.668.651.568.291', 'D06.472.334.851.437.968.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.668.651.693.762.450'], ['M01.060.116.630'], ['G08.686.157.500.625', 'G08.686.841.249.500.625'], ['D12.776.124.790.223.800', 'D12.776.157.762', 'D12.776.377.715.182.800']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]']
| 0
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Isokinetic shoulder rotator muscles in wheelchair athletes.
|
OBJECTIVES: To assess the influence of wheelchair propulsion and neurological level on isokinetic shoulder rotational strength.SETTING: University of Montpellier, FranceMETHODS: Data were evaluated in three groups of subjects as follows: 12 nonathletes, 15 tennis players and 21 wheelchair athletes. We then compared 12 high paraplegic athletes (HPA) and nine low paraplegic athletes (LPA) within the group of 21 wheelchair athletes: The isokinetic tests were performed in the seated 45 degrees abducted test position in the scapular plane at 60, 180 and 300 degrees s(-1) for both shoulders. Peak torque and mean power values were gathered and, from these values, the internal/external rotation ratios were calculated.RESULTS: Intergroup comparison showed an influence of lesion and sport on peak torque at 180 and 300 degrees s(-1) for the internal rotators and significantly higher values of the internal/external ratios in the wheelchair athlete group. For mean power, we observed significant differences under all test conditions and significant differences for ratio only on the dominant side at 180 degrees s(-1) and on the dominant side at 300 degrees s(-1). Comparison of the two groups of paraplegic athletes showed significantly higher values of peak torque and mean power of the external rotators in the LPA for all test conditions.CONCLUSIONS: Neurological level of lesion does not systematically influence the development of internal rotator muscles; in contrast, the participation of the external rotators appears strongly correlated to neurological level. The comparison of the two sides in the two paraplegic groups showed that in two-thirds of the cases the values of the external rotators were significantly higher than those of the internal rotators on the nondominant side for peak torque and mean power. Ratios on the dominant side were systematically higher than on the nondominant side, with significant differences also noted in two-thirds of the cases. These results raise questions about the influence of neurological level and wheelchair propulsion on the muscular adaptations of the shoulder in wheelchair athletes.
|
['Adaptation, Psychological', 'Adult', 'Case-Control Studies', 'Female', 'Humans', 'Injury Severity Score', 'Male', 'Movement', 'Muscle Contraction', 'Paraplegia', 'Physical Endurance', 'Probability', 'Reference Values', 'Risk Assessment', 'Sensitivity and Specificity', 'Shoulder Joint', 'Spinal Cord Injuries', 'Sports', 'Statistics, Nonparametric', 'Wheelchairs']
| 15,060,519
|
[['F01.058'], ['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.940.968.875.500', 'E05.944.600', 'N04.452.859.564.800.500', 'N05.715.360.300.715.500.800.400'], ['G07.568', 'G11.427.410'], ['G11.427.494'], ['C10.597.622.669', 'C23.888.592.636.637'], ['G11.427.680', 'I03.450.642.845.054.600'], ['E05.318.740.600', 'G17.680', 'N05.715.360.750.625', 'N06.850.520.830.600'], ['E05.978.810'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['A02.835.583.748'], ['C10.228.854.763', 'C10.900.850', 'C26.819'], ['I03.450.642.845'], ['E05.318.740.995', 'N05.715.360.750.760', 'N06.850.520.830.995'], ['E07.796.980']]
|
['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]']
| 1
| 1
| 1
| 0
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 1
| 0
|
Fecal incontinence treated by sacral neuromodulation: Long-term follow-up of 325 patients.
|
BACKGROUND: Long-term results of large patient cohorts with fecal incontinence treated by sacral neuromodulation are limited. This study shows the long-term results after a mean follow-up of 7.1 years in 325 patients with fecal incontinence treated by continuous sacral neuromodulation.METHODS: All patients with fecal incontinence and eligible for sacral neuromodulation between 2000 and 2015 were evaluated retrospectively. Primary outcome was a decrease in episodes of fecal incontinence, which was defined as involuntary fecal loss at least once per week and documented by a 3 week bowel habit diary. Quality of life was assessed using the Short-Form 36 and the Fecal Incontinence Quality of Life Score.RESULTS: In the study, 374 patients were included for sacral neuromodulation screening and 325 patients (32 male, 9.7%) received permanent, continuous sacral neuromodulation. Mean age was 56.5 years (17-82 years) and mean follow-up was 7.1 years (3.0-183.4 months). In the 325 patients with permanent sacral neuromodulation, fecal incontinence episodes decreased from a mean of 16.1 ± 14.5 to 3.0 ± 3.7 per 3-week period after sacral neuromodulation (P < .001) according to the bowel habit diary. Sacral neuromodulation was removed due to unsatisfactory results in 81 patients. Quality of life (both Short-Form 36 and Fecal Incontinence Quality of Life Score) showed no significant difference compared with the Dutch population during follow-up.CONCLUSION: Long-term efficacy of sacral neuromodulation can be maintained in about half (52.7%) of all patients screened with sacral neuromodulation for fecal incontinence after a mean follow-up of 7.1 years. Importantly, the quality of life of patients with sacral neuromodulation for fecal incontinence did not differ from the general population.
|
['Adult', 'Aged', 'Anal Canal', 'Cohort Studies', 'Electric Stimulation Therapy', 'Fecal Incontinence', 'Female', 'Humans', 'Lumbosacral Plexus', 'Male', 'Middle Aged', 'Patient Satisfaction', 'Quality of Life', 'Retrospective Studies', 'Sacrum', 'Severity of Illness Index', 'Treatment Outcome']
| 28,159,117
|
[['M01.060.116'], ['M01.060.116.100'], ['A03.556.124.526.070', 'A03.556.249.249.070'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['C06.405.469.860.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.800.800.720.450'], ['M01.060.116.630'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', 'N05.300.150.800.625', 'N05.715.360.600'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['A02.835.232.834.717'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]']
| 1
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 1
| 0
|
Outpatient costing and classification: are we any closer toa national standard for ambulatory classification systems?
|
The Outpatient Costing and Classification Study was commissioned by the Department of Health and Family Services to evaluate the suitability of the Developmental Ambulatory Classification System (DACS). Data on the full range of ambulatory services (outpatient clinics, emergency departments and allied health services) were collected prospectively from a stratified sample of 28 public hospitals. Patient encounters captured in the study represent 1% of the total ambulatory encounters in Australia in one year. Costing per encounter included time spent with the patient, cost of procedures, indirect costs (salaries and consumables), overhead costs and diagnostic costs. The most significant variable explaining cost variation was hospital type, followed by outpatient clinic type. Visit type and presence or absence of a procedure--major splits for the proposed DACS--did not produce splits that were consistent across all hospital strata. The study found that DACS is not an appropriate classification for hospital ambulatory services. A clinic-based structure for outpatients and allied health departments is recommended for classifying and funding ambulatory services in Australia.
|
['Ambulatory Care', 'Australia', 'Diagnosis-Related Groups', 'Emergency Medical Services', 'Health Services Research', 'Hospital Costs', 'Humans', 'Outpatient Clinics, Hospital']
| 9,830,407
|
[['E02.760.106', 'N02.421.585.106'], ['Z01.639.100', 'Z01.678.100.373'], ['N03.219.521.710.305.200.080'], ['N02.421.297'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['N03.219.151.400.687', 'N03.219.262.500', 'N05.300.375.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.035.380', 'N02.278.216.500.968.527', 'N04.452.442.452.422.527']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]']
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
|
Bifidobacterium longum CECT 7347 modulates immune responses in a gliadin-induced enteropathy animal model.
|
Coeliac disease (CD) is an autoimmune disorder triggered by gluten proteins (gliadin) that involves innate and adaptive immunity. In this study, we hypothesise that the administration of Bifidobacterium longum CECT 7347, previously selected for reducing gliadin immunotoxic effects in vitro, could exert protective effects in an animal model of gliadin-induced enteropathy. The effects of this bacterium were evaluated in newborn rats fed gliadin alone or sensitised with interferon (IFN)-ã and fed gliadin. Jejunal tissue sections were collected for histological, NFêB mRNA expression and cytokine production analyses. Leukocyte populations and T-cell subsets were analysed in peripheral blood samples. The possible translocation of the bacterium to different organs was determined by plate counting and the composition of the colonic microbiota was quantified by real-time PCR. Feeding gliadin alone reduced enterocyte height and peripheral CD4+ cells, but increased CD4+/Foxp3+ T and CD8+ cells, while the simultaneous administration of B. longum CECT 7347 exerted opposite effects. Animals sensitised with IFN-ã and fed gliadin showed high cellular infiltration, reduced villi width and enterocyte height. Sensitised animals also exhibited increased NFêB mRNA expression and TNF-á production in tissue sections. B. longum CECT 7347 administration increased NFêB expression and IL-10, but reduced TNF-á, production in the enteropathy model. In sensitised gliadin-fed animals, CD4+, CD4+/Foxp3+ and CD8+ T cells increased, whereas the administration of B. longum CECT 7347 reduced CD4+ and CD4+/Foxp3+ cell populations and increased CD8+ T cell populations. The bifidobacterial strain administered represented between 75-95% of the total bifidobacteria isolated from all treated groups, and translocation to organs was not detected. These findings indicate that B. longum attenuates the production of inflammatory cytokines and the CD4+ T-cell mediated immune response in an animal model of gliadin-induced enteropathy.
|
['Animals', 'Animals, Newborn', 'Bifidobacterium', 'Biological Therapy', 'CD4-Positive T-Lymphocytes', 'Celiac Disease', 'Cytokines', 'Disease Models, Animal', 'Female', 'Gliadin', 'Immunity', 'Inflammation', 'Mice', 'Mice, Inbred C57BL', 'Rats']
| 22,348,021
|
[['B01.050'], ['B01.050.050.282'], ['B03.510.024.100', 'B03.510.460.400.400.049.100'], ['E02.095'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['C06.405.469.637.250', 'C18.452.603.250'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.776.765.433.500.500.400', 'D12.776.765.725.500.500.400'], ['G12.450'], ['C23.550.470'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.150.900.649.313.992.635.505.700']]
|
['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe
|
While the Mre11-Rad50-Nbs1 (MRN) complex has known roles in repair processes like homologous recombination and microhomology-mediated end-joining, its role in nonhomologous end-joining (NHEJ) is unclear as Saccharomyces cerevisiae, Schizosaccharomyces pombe, and mammals have different requirements for repairing cut DNA ends. Most double-strand breaks (DSBs) require nucleolytic processing prior to DNA ligation. Therefore, we studied repair using the Hermes transposon, whose excision leaves a DSB capped by hairpin ends similar to structures generated by palindromes and trinucleotide repeats. We generated single Hermes insertions using a novel S. pombe transient transfection system, and used Hermes excision to show a requirement for MRN in the NHEJ of nonligatable ends. NHEJ repair was indicated by the >1000-fold decrease in excision in cells lacking Ku or DNA ligase 4. Most repaired excision sites had <5 bp of sequence loss or mutation, characteristic for NHEJ and similar excision events in metazoans, and in contrast to the more extensive loss seen in S. cerevisiaeS. pombe NHEJ was reduced >1000-fold in cells lacking each MRN subunit, and loss of MRN-associated Ctp1 caused a 30-fold reduction. An Mre11 dimer is thought to hold DNA ends together for repair, and Mre11 dimerization domain mutations reduced repair 300-fold. In contrast, a mre11 mutant defective in endonucleolytic activity, the same mutant lacking Ctp1, or the triple mutant also lacking the putative hairpin nuclease Pso2 showed wild-type levels of repair. Thus, MRN may act to recruit the hairpin opening activity that allows subsequent repair.
|
['Chromosomal Proteins, Non-Histone', 'DNA', 'DNA Breaks, Double-Stranded', 'DNA End-Joining Repair', 'DNA-Binding Proteins', 'Endodeoxyribonucleases', 'Exodeoxyribonucleases', 'Multiprotein Complexes', 'Schizosaccharomyces', 'Schizosaccharomyces pombe Proteins']
| 28,292,918
|
[['D12.776.660.235', 'D12.776.664.235'], ['D13.444.308'], ['G05.200.210.220'], ['G02.111.222.200', 'G05.219.200'], ['D12.776.260'], ['D08.811.277.352.335.350', 'D08.811.277.352.355.325'], ['D08.811.277.352.335.375', 'D08.811.277.352.365.290'], ['D05.500'], ['B01.300.107.797', 'B01.300.930.720'], ['D12.776.354.875']]
|
['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]']
| 0
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
[Intra-arterial and intraportal infusion liver scintigraphy using 99mTc-labeled colloid].
|
Intra-arterial infusion liver scintigraphy was performed in 11 patients with primary or metastatic liver tumor, and intraportal infusion liver scintigraphy was performed in 6 patients for prophylaxis of liver metastasis from colorectal cancer. 99mTc-Sn colloid or 99mTc-phytate was administered through the catheter of which tip was placed in the portal vein or the hepatic artery, and then liver image was obtained. When 99mTc-phytate was infused intra-arterially, significant amount of the infused tracer passed through the liver and we could not get sufficient information to assess the distribution of drug administered through the catheter. On the other hand, intraportal infusion liver scintigraphy using 99mTc-Sn colloid or 99mTc-phytate and intra-arterial infusion liver scintigraphy using 99mTc-Sn colloid revealed heterogeneity of liver uptake, tracer uptake in spleen, low uptake area corresponding to the liver tumor and high uptake area around it. The findings will be clinically useful, and these methods are thought to be helpful to confirm the satisfactory drug distribution.
|
['Adult', 'Aged', 'Female', 'Humans', 'Infusions, Intra-Arterial', 'Infusions, Intravenous', 'Liver', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Organotechnetium Compounds', 'Phytic Acid', 'Portal Vein', 'Radionuclide Imaging', 'Technetium', 'Technetium Compounds', 'Tin', 'Tin Compounds']
| 1,784,089
|
[['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.510.520'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['A03.620'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['M01.060.116.630'], ['D02.691.825'], ['D02.033.800.519.400.700', 'D09.853.519.400.700', 'D09.894.480.700'], ['A07.015.908.670.567'], ['E01.370.350.710', 'E01.370.384.730'], ['D01.268.271.870', 'D01.268.556.843', 'D01.268.956.875', 'D01.496.749.305.870', 'D01.552.544.843'], ['D01.925'], ['D01.268.556.875', 'D01.552.544.875'], ['D01.935']]
|
['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]']
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Mechanism of Na+/proline symport in Escherichia coli: reappraisal of the effect of cation binding to the Na+/proline symport carrier.
|
The proton and sodium ion dependences of the proline binding and transport activities of the proline carrier in Escherichia coli were investigated in detail. The binding activity in cytoplasmic membrane vesicles from a carrier over-producing strain (PT21/pTMP5) was absolutely dependent on the presence of Na+, but did not necessarily require protonation of the carrier, in contrast to the model previously reported (Mogi, T., Anraku, Y. 1984. J. Biol. Chem. 259:7797-7801). Based on this and previous observations, we propose a modified model of the proline binding reaction of the proline carrier, in which a proton is supposed to be a regulatory factor for the binding activity. The apparent Michaelis constant of proline (Kt) of the transport activity of cytoplasmic membrane vesicles from the wild type E. coli strain driven by a respiratory substrate, ascorbate, showed dependence on a low concentration of sodium ion. The Michaelis constant of sodium ion for transport (KtNa) was estimated to be 25 microM. The proline transport activities in membrane vesicles and intact cells were modulated by H+ concentration, the inhibitory effect of protons (pKa approximately equal to 6) being similar to that observed previously (Mogi, T., Anraku, Y. 1984. J. Biol. Chem. 259:7802-7806). Based on these observations and the modified model of substrate binding to the proline carrier, a model of the proline/Na+ symport mechanism is proposed, in which a proton is postulated to be a regulatory factor of the transport activity.
|
['Amino Acid Transport Systems, Neutral', 'Biological Transport', 'Carrier Proteins', 'Cations', 'Chlorides', 'Escherichia coli', 'Escherichia coli Proteins', 'Hydrogen-Ion Concentration', 'Kinetics', 'Lithium', 'Lithium Chloride', 'Models, Chemical', 'Proline', 'Protons', 'Sodium', 'Sodium Chloride', 'Symporters']
| 2,160,541
|
[['D12.776.157.530.200.500', 'D12.776.543.585.200.500'], ['G03.143'], ['D12.776.157'], ['D01.248.497.300'], ['D01.210.450.150', 'D01.248.497.158.215'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['D01.268.549.450', 'D01.268.557.290', 'D01.552.528.480', 'D01.552.547.290'], ['D01.210.450.150.450', 'D01.510.500'], ['E05.599.495'], ['D12.125.072.401.623'], ['D01.248.497.300.459.700', 'D01.268.406.750', 'D01.362.340.750', 'G01.249.660.500'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850', 'D01.552.547.725'], ['D01.210.450.150.875', 'D01.857.650'], ['D12.776.157.530.450.625', 'D12.776.543.585.450.625']]
|
['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 0
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Fate of antacid gel in the stomach. Site of action and interaction with food.
|
The site of action of a high-power Al-Mg antacid gel (buffering capacity 70 meq/10 ml) and its interaction with food was examined in 10 healthy volunteers. Combined pH-metries in antrum and corpus were performed in each volunteer on four occasions. In a randomized study design, antacid or placebo were given 1 hr after either a protein or a carbohydrate pancake, of which only the former had any acid-buffering capacity. Before the meal, pH was higher in the antrum than in the corpus (median antrum: 3.2, corpus 1.5). In the corpus, a protein pancake but not a carbohydrate pancake raised the pH (median pH after protein pancake: 3.5; after carbohydrate pancake: 1.4). In the antrum, the protein pancake had no effect, but the carbohydrate pancake decreased the pH (median pH after protein pancake: 3.1; after carbohydrate pancake: 2.0). The antacid had no effect in the corpus after either pancake. It raised intraluminal pH markedly in the antrum after a carbohydrate pancake (median antral pH before antacid: 2.0; after antacid: 3.3), whereas its effect in the antrum was weak after a protein pancake. In vitro experiments were conducted to explain the in vivo results: in contrast to a carbohydrate pancake, a protein pancake reduced the buffering capacity of the antacid by direct interaction. In conclusion, the effect of an antacid gel on intragastric pH is predominantly localized in the antrum and is attenuated in the presence of proteins.(ABSTRACT TRUNCATED AT 250 WORDS)
|
['Adult', 'Antacids', 'Dietary Carbohydrates', 'Dietary Proteins', 'Drug Interactions', 'Female', 'Gastric Acidity Determination', 'Gastric Emptying', 'Humans', 'Hydrogen-Ion Concentration', 'Male', 'Random Allocation', 'Stomach']
| 2,331,951
|
[['M01.060.116'], ['D27.505.519.170', 'D27.505.954.483.080'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['G07.690.773.968'], ['E01.370.225.124.300', 'E01.370.372.300', 'E05.200.124.300'], ['G10.261.360.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], ['A03.556.875.875']]
|
['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 1
| 1
| 0
|
Suramin, an active drug for prostate cancer: interim observations in a phase I trial.
|
BACKGROUND: Previous studies indicate that suramin may be an active agent for treatment of solid tumors. The clinical use of suramin is complicated by a broad spectrum of toxic effects and complex pharmacology. Studies have suggested that the dose-limiting neurotoxicity of this agent is closely related to sustained plasma drug concentrations of 350 micrograms/mL or more.PURPOSE: This phase I clinical trial in patients with solid tumors was designed to determine whether plasma concentrations resulting in both antitumor activity and manageable toxicity could be achieved with short, intermittent infusions of suramin.METHODS: Thirty-seven patients, including 33 with metastatic, hormone-refractory prostate cancer, collectively received 43 courses of suramin designed to maintain a plasma concentration range of 200-300, 175-275, or 150-250 micrograms/mL. Patients received a test dose of 200 mg and an initial loading dose of 1000 mg/m2 on day 1 of therapy. Subsequent suramin doses and schedules were individually determined using a strategy of adaptive control with feedback, which used a maximum a posteriori Bayesian algorithm to estimate individual pharmacokinetic parameters. Patients were treated until dose-limiting toxicity or progressive disease developed.RESULTS: Thirty-five of the 37 study patients and 31 of the 33 with prostate cancer were assessable for toxicity and response. Treatment was discontinued in 28 patients because of dose-limiting toxicity consisting of a syndrome of malaise, fatigue, and lethargy; recurrent reduction in creatinine clearance of 50% or more; or axonal neuropathy. Evidence of major antitumor activity was observed in patients with prostate cancer treated at all three plasma drug concentrations. Measurable responses (one complete response and five partial responses) were noted in six of 12 patients with measurable disease. Twenty-four (77%) of 31 patients had a reduction in prostate-specific antigen of 50% or more, and 17 (55%) of 31 had a reduction of 75% or more. Twenty (83%) of 24 patients reported reduction in pain.CONCLUSIONS: Suramin can be safely administered as an intermittent bolus injection by use of adaptive control with feedback to control plasma drug concentrations; toxicity is significant but manageable and reversible. Suramin is active against hormone-refractory prostate cancer.IMPLICATIONS: Future trials should address the role and necessary extent of therapeutic drug monitoring; the optimal plasma drug concentration range and duration of therapy; and the activity of suramin in combination with other agents, in earlier stages of prostate cancer, and in other tumor types.
|
['Aged', 'Antineoplastic Agents', 'Drug Administration Schedule', 'Humans', 'Infusions, Intravenous', 'Male', 'Middle Aged', 'Prostatic Neoplasms', 'Suramin', 'Treatment Outcome']
| 8,468,719
|
[['M01.060.116.100'], ['D27.505.954.248'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['M01.060.116.630'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['D02.455.426.559.847.638.555.750', 'D02.886.645.600.080.050.650.750', 'D04.615.638.555.750'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]']
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Genetic and molecular studies of the regulation of atypical citrate utilization and variable Vi antigen expression in enteric bacteria.
|
1. The atypical citrate-utilizing ability to two strains of E. coli has been shown to be plasmid-encoded. Strain V414 carries a 130 Mdal conjugative Cit+ plasmid that also specifies Tcr and Cmr. Strain V517 carries 9 different plasmid species but only the 36 Mdal species is correlated with Cit+ ability. These plasmids are different from previously reported Cit+ plasmids of E. coli and Salmonella, which express thermosensitive conjugal transfer systems. 2. A 9 kb Pstl fragment, carrying the Cit+ genes of pWR60, has been cloned into the pBR325 plasmid. 3. Metabolic studies indicate that intact citrate is not incorporated directly into whole cells. Rather, atypical citrate utilization by these E. coli strains appears to involve partial metabolism of citrate at the cell surface before or during uptake. 4. The expression of atypical Cit+ ability by the parental pWR60 plasmid or by the recombinant pWR61 plasmid appears reversible and may involve an expression switch mechanism (i.e., insertion sequence element). 5. Two widely separated genetic loci, viaA and viaB, are necessary for Vi antigen synthesis in Salmonella and Citrobacter. In some strains of C. freundii, Vi antigen expression is reversible, a phenomenon which can be visualized by a colonial morphology transition between Vi-expressing and -nonexpressing forms. 6. The C. freundii viaB locus appears to encode the Vi antigen as well as the genetic "switch" mechanism controlling reversible Vi antigen expression. The viaA locus, which is found in several different bacterial species, may encode some common property (e.g., cell surface structure or enzymatic activity) that is needed for Vi antigen expression. 7. S. typhi and E. coli K12 hybrid strains which carry the C. freundii viaB locus have been constructed. These hybrid strains express reversible Vi antigen expression, even in the absence of general recombination (i.e., functional recA gene product). 8. The C. freundii viaB locus was transposed via Mu-mediated events to an F'lac plasmid in the E. coli K12 hybrid strain WR2376. F' plasmids carrying the viaB locus should serve as a highly enriched source of viaB DNA for physical examination of the switch mechanism. 9. Genetic manipulations such as those described herein can be used to study virtually any plasmid, viral, or chromosomally-encoded property. The resultant better understanding of biochemical pathways and of genetic regulatory control systems, and the isolation of desired gene sequences should provide ample information and materials for improving chemical processes and constructing vaccines against various organisms.
|
['Antigens, Bacterial', 'Citrates', 'Citric Acid', 'Enterobacteriaceae', 'Escherichia coli', 'Gene Expression Regulation', 'Genes, Bacterial', 'Plasmids']
| 7,039,598
|
[['D23.050.161'], ['D02.241.081.901.434'], ['D02.241.081.901.434.249'], ['B03.440.450.425', 'B03.660.250.150'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.308'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G05.360.600']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]']
| 0
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
[Clinical investigation of basophil activation test as a complementary test for house dust mite allergen].
|
Objective:To investigate the clinical application of glass micro fiber basophil activation test (BAT) used as a complementary test for house dust mite allergen.Method:Forty patients with clinical diagnosed allergic rhinitis was test by three methods for house dust mite allergen, skin prick test(SPT),Immuno CAP sIgE, and BAT in vitro. The sensitivity and specificity of glass micro fiber were accessed, and the consistency between BAT, SPT, and Immuno sIgE was analyzed. As in vivo provocation was not performed, gold standard is regarded as the combination of medical history and positive reports of SPT and/or ImmunoCAP sIgE test.Result:Twenty?three patients are diagnosed as house dust mite allergic rhinitis by gold standard. The sensitivity and specificity of glass micro fiber BAT were 60.9% and 88.2%, the sensitivity of SPT and sIgE was 87.0% and sIgE 73.9%. The correlation rates between BAT with SPT is 0.67(P<0.05), and sIgE 0.55(P<0.05). The accuracy, predictive value of positive and negative of BAT are 0.47,60.9%,88.2%.The Kappa values of BAT, SPT and sIgE with gold standard are 0.47,0.86,0.71.Conclusion:As a complementary test for house dust mite allergic rhinitis, BAT have a good consistency with SPT and sIgE, while as it has only moderate consistency with "gold standard", further studies are needed to prove its clinical significance.
|
['Allergens', 'Animals', 'Antigens, Dermatophagoides', 'Basophils', 'Dust', 'Humans', 'Immunoglobulin E', 'Pyroglyphidae', 'Skin Tests']
| 29,798,295
|
[['D23.050.063'], ['B01.050'], ['D23.050.181'], ['A11.118.637.415.120', 'A11.627.340.120', 'A15.145.229.637.415.120', 'A15.382.490.315.120'], ['D20.633.222'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D12.776.377.715.548.114.619.312'], ['B01.050.500.131.166.132.419.600'], ['E01.370.225.812.871', 'E05.200.812.871', 'E05.478.594.890']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Tractography-based Parcellation of the Human Middle Temporal Gyrus.
|
The middle temporal gyrus (MTG) participates in a variety of functions, suggesting the existence of distinct functional subregions. In order to further delineate the functions of this brain area, we parcellated the MTG based on its distinct anatomical connectivity profiles and identified four distinct subregions, including the anterior (aMTG), middle (mMTG), posterior (pMTG), and sulcus (sMTG). Both the anatomical connectivity patterns and the resting-state functional connectivity patterns revealed distinct connectivity profiles for each subregion. The aMTG was primarily involved in the default mode network, sound recognition, and semantic retrieval. The mMTG was predominantly involved in the semantic memory and semantic control networks. The pMTG seems to be a part of the traditional sensory language area. The sMTG appears to be associated with decoding gaze direction and intelligible speech. Interestingly, the functional connectivity with Brodmann's Area (BA) 40, BA 44, and BA 45 gradually increased from the anterior to the posterior MTG, a finding which indicated functional topographical organization as well as implying that language processing is functionally segregated in the MTG. These proposed subdivisions of the MTG and its functions contribute to understanding the complex functions of the MTG at the subregional level.
|
['Algorithms', 'Diffusion Tensor Imaging', 'Humans', 'Nerve Net', 'Rest', 'Temporal Lobe']
| 26,689,815
|
[['G17.035', 'L01.224.050'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.511'], ['I03.450.769.647'], ['A08.186.211.200.885.287.500.863']]
|
['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]']
| 1
| 1
| 0
| 0
| 1
| 0
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
|
Physiatric therapeutics. 3. Traction, manipulation, and massage.
|
This self-directed learning module highlights advances in this topic area. It is part of the chapter on physiatric therapeutics for the Self-Directed Medical Knowledge Program Study Guide for practitioners and trainees in physical medicine and rehabilitation. This section discusses physiologic effects of, and indications and contraindications for, traction, manipulation, and massage. Advances covered in this section include hypotheses of pain relief in manipulation.
|
['Humans', 'Manipulation, Orthopedic', 'Massage', 'Pain Management', 'Physical Therapy Modalities', 'Traction']
| 2,322,106
|
[['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.718.625', 'E02.779.867.433', 'E02.831.535.867.433'], ['E02.190.599.750.750', 'E02.779.867.880.750', 'E02.831.535.867.880.750'], ['E02.745', 'N04.590.607.500'], ['E02.779', 'E02.831.535'], ['E04.555.720']]
|
['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]']
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
|
[Hyperlactacidemia during antiretroviral therapy: frequency and clinical-therapeutic correlations].
|
While asymptomatic hyperlactacidemia is quite a frequent phenomenon among HIV-infected patients treated with highly active antiretroviral therapy (HAART), lactic acidosis is a rare, but potentially life-threatening occurrence. Epidemiology, clinical and laboratory presentation, evolution, and outcome of this phenomenon are currently under intensive investigation, and the most likely pathogenetic pathways seem to involve mitochondrial toxicity prompted by the administration of nucleoside reverse transcriptase inhibitors. Our case-control study on an extensive, single centre population treated for HIV infection provides novel insights on these emerging issues, reported and discussed on the basis of the most recently published findings.
|
['Adult', 'Anti-HIV Agents', 'Antiretroviral Therapy, Highly Active', 'Case-Control Studies', 'Comorbidity', 'Dyslipidemias', 'Female', 'HIV Infections', 'HIV-Associated Lipodystrophy Syndrome', 'Humans', 'Lactic Acid', 'Male', 'Middle Aged', 'Mitochondria, Heart', 'RNA, Viral', 'Reverse Transcriptase Inhibitors']
| 16,794,377
|
[['M01.060.116'], ['D27.505.954.122.388.077.088'], ['E02.319.310.075'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['N05.715.350.225', 'N06.850.490.687'], ['C18.452.584.500'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['C01.221.250.875.550', 'C01.221.812.640.400.530', 'C01.778.640.400.530', 'C01.925.782.815.616.400.550', 'C01.925.813.400.530', 'C17.800.849.391.400', 'C18.452.584.625.400', 'C18.452.880.391.400', 'C20.673.480.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.511.459.450'], ['M01.060.116.630'], ['A11.284.430.214.190.875.564.627.603', 'A11.284.835.626.627.603'], ['D13.444.735.828'], ['D27.505.519.389.675.850', 'D27.505.954.122.388.308']]
|
['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]']
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Increased uptake and utilization of glucose by diaphragms of rats exposed to chronic centrifugation.
|
Weaning female Sprague-Dawley rats were exposed to 2.76 or 4.15 G for periods ranging from 2 to 20 wk. The isolated diaphragm tissues from these rats were studied in vitro to determine the uptake of glucose and its utilization to CO2 and glycogen. The diaphragm muscle tissues obtained from centrifuged rats showed higher rates of glucose uptake and 14CO2 production from [U-14C]glucose than those obtained from noncentrifuged controls, but no significant differences in the rate of incorporation of [U-14C]glucose into glycogen were observed. Rats centrifuged for 12 wk at 4.15 G continued to show an increase in diaphragm tissue glucose uptake for periods up to 2 wk after return to normal gravity. The stimulating effect of insulin on the uptake of glucose and its incorporation into glycogen was much higher in the diaphragms of centrifuged rats. From the results of this study, it is concluded that one of the adaptive responses of rats to chronic centrifugation is an increase in glucose metabolism of their muscle tissues.
|
['Adaptation, Physiological', 'Animals', 'Body Weight', 'Carbon Dioxide', 'Centrifugation', 'Diaphragm', 'Female', 'Glucose', 'Glycogen', 'Gravitation', 'Insulin', 'Muscles', 'Rats', 'Stimulation, Chemical', 'Time Factors']
| 1,115,239
|
[['G07.025', 'G16.012.500'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['E05.181'], ['A02.633.567.900.300'], ['D09.947.875.359.448'], ['D05.750.078.562.388', 'D09.698.365.388'], ['G01.060.350'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['A02.633', 'A10.690'], ['B01.050.150.900.649.313.992.635.505.700'], ['G07.690.773.996'], ['G01.910.857']]
|
['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
A Rasch Analysis Validation of the Maslach Burnout Inventory-Student Survey with Preclinical Medical Students.
|
Construct: Burnout is a psychological construct characterized by emotional exhaustion that arises from an excess of physical, emotional, and social demands over an extended period. Symptoms of burnout include withdrawal or disengagement from work. Burnout has become an important public health concern due to its association with severe negative consequences across numerous professions.BACKGROUND: The most widely used instrument for measuring burnout is the Maslach Burnout Inventory (MBI). An adaptation of the MBI, the MBI-Student Survey (MBI-SS), was developed for college students. The MBI-SS consists of 15 items covering 3 domains of burnout: exhaustion, cynicism (CY), and professional efficacy (PE). Although studies have confirmed the validity of the MBI-SS for college student populations, studies of its use with medical students are limited. The purpose of this study was to employ the Rasch model to examine the psychometric properties of the MBI-SS when used with a population of preclinical medical students.APPROACH: Data were collected from 787 medical students who answered the MBI-SS at the conclusion of their 1st year. A maximum likelihood exploratory factor analysis for ordinal data confirmed the hypothesized three factor structure of the MBI-SS. Subsequently, a Rasch analysis was employed to further evaluate the measurement properties of MBI-SS. We used the Rasch Rating Scale model to investigate the extent to which the three MBI subscales conformed to proper measurement characteristics, including comprehensive coverage of person ability and item difficulty along the latent continuum.RESULTS: Most of the 15 items on the MBI-SS effectively fit the Rasch Rating Scale Model, with minimal measurement error. Respondents effectively used the full range of the rating scale for all 15 items. Two subscales (PE and CY) contained items that were difficult for respondents to endorse, resulting in significant gaps along the measurement continuum. The CY subscale exhibited a slight floor effect. The 3 subscales showed good person reliability, good real-item reliability, and good person separation.CONCLUSIONS: The Rasch analysis confirmed that the MBI-SS works well for measuring burnout among preclinical medical students. However, the Rasch analysis was able to identify that additional items are needed to improve the performance of MBI-SS. New items would be targeted at reducing the floor effect for the CY subscale and filling the other gaps in measurement along the latent continuum for the PE and CY subscales.
|
['Burnout, Professional', 'Education, Medical, Undergraduate', 'Female', 'Humans', 'Male', 'Psychometrics', 'Students, Medical', 'Surveys and Questionnaires']
| 30,577,705
|
[['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['I02.358.399.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.780'], ['M01.848.769.602'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']]
|
['Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]']
| 0
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 1
| 0
|
LncRNA profiling of skeletal muscles in Large White pigs and Mashen pigs during development.
|
Long noncoding RNA (lncRNA) has been increasingly implicated in the regulation of muscle development. Large White pigs have a higher muscle growth rate than do Mashen pigs. In the present study, the lncRNA expression profiles in skeletal muscle of these 2 pig breeds were compared at 1, 90, and 180 d of age using RNA sequencing. We obtained 2,718 million clean reads and identified a total of 5,153 novel lncRNA. We found 1,407 differentially expressed lncRNA that showed consistent expression patterns between the 2 breeds at all the 3 sampling points. Ten lncRNA were randomly selected, and their expression was validated using Real-time Quantitative PCR. In summary, this study identifies a number of lncRNA that correlate with muscle growth. The regulation and function of these lncRNA in muscle growth and development need to be further explored.
|
['Animals', 'Base Sequence', 'Gene Expression Profiling', 'Male', 'Muscle Development', 'Muscle, Skeletal', 'RNA, Long Noncoding', 'Random Allocation', 'Sequence Analysis, RNA', 'Swine']
| 29,108,073
|
[['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.332'], ['G07.345.500.325.377.625.590', 'G11.427.578.590'], ['A02.633.567', 'A10.690.552.500'], ['D13.444.735.790.375'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], ['E05.393.760.710'], ['B01.050.150.900.649.313.500.880']]
|
['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 1
| 0
| 1
| 0
|
Curative effect of warming kidney and fortifying spleen recipe on diarrhea-predominant irritable bowel syndrome.
|
OBJECTIVE: To observe the curative effect of a recipe for warming the kidney and fortifying the spleen on diarrhea-predominant irritable bowel syndrome (IBS-D).METHODS: This multi-center, double-blind, randomized, and controlled trial included 240 patients that met the inclusion criterion and were then divided into two groups of 120. Patients in the treatment group (group A) took modified Sishen Wan orally for warming the kidney and fortifying the spleen and patients in the control group (group B) took a placebo, Chao Maiya, for 4 weeks. 28 days after withdrawal, there was a 6-month follow-up to observe patient recurrence condition. The total effective rate, curative effect, and recurrence rate were evaluated after treatment.RESULTS: There was statistical difference (P < 0.01) between the two groups in total effective rate (92.24% in the treatment group and 49.07% in the control group), in curative effect of TCM syndrome (90.52% and 47.22%, respectively), and in the recurrence rate (15.79% and 56.86%, respectively) within 6 months after treatment.CONCLUSION: Modified Sishen Wan, for warming the kidney and fortifying the spleen, can effectively treat IBS-D and better control its recurrence.
|
['Adolescent', 'Adult', 'Aged', 'Diarrhea', 'Drugs, Chinese Herbal', 'Female', 'Humans', 'Irritable Bowel Syndrome', 'Kidney', 'Male', 'Middle Aged', 'Spleen', 'Treatment Outcome', 'Young Adult']
| 24,660,584
|
[['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C23.888.821.214'], ['D20.215.784.500.350', 'D26.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.158.272.608'], ['A05.810.453'], ['M01.060.116.630'], ['A10.549.700', 'A15.382.520.604.700'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['M01.060.116.815']]
|
['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]']
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Proposal for selection criteria of secondary cytoreductive surgery in recurrent epithelial ovarian, tubal, and peritoneal cancers.
|
BACKGROUND: The selection criteria for secondary cytoreductive surgery (SCS) in recurrent ovarian cancer are yet to be defined. The aim of this study was to propose the selection criteria through identifying predictive factors for successful SCS.METHODS: All patients who underwent SCS for recurrent epithelial ovarian, tubal, and peritoneal cancers between 1982 and 2012 at our institution were identified through our database. Potential prognostic factors were evaluated in univariate and multivariate analyses. Survival after SCS was examined by the grouping model based on the number of prognostic factors.RESULTS: We performed SCS in 80 consecutive patients, 48 (60 %) of whom achieved complete resection. Complete/incomplete resection significantly influenced survival (median 65 vs. 26 months; p = 0.0005). Among favorable prognostic factors determined before SCS, treatment-free interval >12 months, absent distant metastasis, solitary disease, and performance status 0 were independently associated with better survival (p = 0.0009, 0.00003, 0.0004, and 0.015, respectively). Patients with 3-4 of those factors had better survival than those with 2 or 0-1 factors (median 79, 26, and 19 months; p < 0.00001 and <0.0000000001, respectively). Complete resection of visible tumors was achieved in 79 % of patients with 3-4 factors, in 40 % of those with 2 factors, and in 33 % of those with 0-1 factor. Importantly, even when tumor removal was incomplete at SCS, median survival of patients with 3-4 factors was still quite favorable (83 vs. 67.5 months for complete/incomplete resection, respectively), while those of patients with 2 factors (41 vs. 25 months) and 0-1 factor (19 vs. 19 months) were not.CONCLUSION: We strongly recommend SCS for patients with 3-4 of the above favorable factors at recurrence. As for patients with 2 factors, SCS may be considered if complete resection is expected to be achieved. Prospective studies are warranted to validate our proposal.
|
['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Ovarian Epithelial', 'Cytoreduction Surgical Procedures', 'Disease-Free Survival', 'Fallopian Tube Neoplasms', 'Female', 'Humans', 'Middle Aged', 'Multivariate Analysis', 'Neoplasm Metastasis', 'Neoplasm Recurrence, Local', 'Neoplasms, Glandular and Epithelial', 'Ovarian Neoplasms', 'Patient Selection', 'Peritoneal Neoplasms', 'Retrospective Studies', 'Severity of Illness Index', 'Survival Rate', 'Tumor Burden']
| 26,475,355
|
[['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.295', 'C04.588.322.455.199', 'C13.351.500.056.630.705.350', 'C13.351.937.418.685.350', 'C19.344.410.199', 'C19.391.630.705.350'], ['E04.166'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['C04.588.945.418.365', 'C13.351.500.056.390.390', 'C13.351.937.418.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['C04.697.650', 'C23.550.727.650'], ['C04.697.655', 'C23.550.727.655'], ['C04.557.470'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'], ['E05.581.500.653', 'N04.590.731'], ['C04.588.033.513', 'C04.588.274.780', 'C06.301.780', 'C06.844.620'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500'], ['E05.318.308.985.550.900', 'N01.224.935.698.826', 'N06.850.505.400.975.550.900', 'N06.850.520.308.985.550.900'], ['E05.041.124.892']]
|
['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]']
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Nurses' interpersonal skills: a study of nurses' perceptions.
|
Six Category Intervention Analysis was used as the framework of a study which involved asking 117 trained nurses to rate their interpersonal skills along six dimensions. The findings suggested that the nurses viewed themselves as being more skilled in offering support, information and prescription in their dealings with patients and less skilled in being catalytic, cathartic and confronting in similar circumstances. The findings in this study were similar to those of previous studies in this field. The study has implications for the development of interpersonal skills training programmes for nurses.
|
['Clinical Competence', 'Communication', 'Humans', 'Interpersonal Relations', 'Nursing Staff', 'Self Concept']
| 1,994,226
|
[['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['M01.526.485.680', 'N02.360.680'], ['F01.752.747.792']]
|
['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Named Groups [M]']
| 0
| 1
| 0
| 0
| 0
| 1
| 0
| 0
| 1
| 0
| 1
| 1
| 1
| 0
|
Neuronal and microglial localization of secreted phosphoprotein 1 (osteopontin) in intact and damaged motor cortex of macaques.
|
We previously reported that mRNA encoding secreted phosphoprotein 1 (SPP1), also known as osteopontin, is preferentially expressed in large neurons in layer V of the macaque motor cortex, most of which are presumed to be corticospinal tract neurons. As a first step to elucidating the cellular function of SPP1 in macaque neurons, we examined the localization of SPP1 in the primary motor cortex (M1) of the macaque by using immunohistochemistry. SPP1 immunoreactivity was found to be localized in the cell bodies of neurons, but not outside the cells, indicating that SPP1 was not secreted from these neurons. The results of electron microscope analysis and double-labeling analysis with marker proteins suggested that SPP1 was localized in the mitochondria of neurons. The distributions of SPP1 in the neurons corresponded to those of integrin áV, a putative receptor for SPP1. The distribution of SPP1 was also investigated in macaques whose M1 had been lesioned. We found that SPP1 was secreted by proliferated microglia in the lesioned area. Double-labeling analysis indicated that SPP1 immunoreactivity in the microglia was colocalized with CD44, another putative receptor for SPP1. Success rates in the small-object-retrieval task were positively correlated with SPP1 immunoreactivity in the neurons in the perilesional area. SPP1 has multiple roles in the macaque motor cortex, and it may be a key protein during recovery of hand movement after brain damage.
|
['Animals', 'Female', 'Hyaluronan Receptors', 'In Situ Hybridization', 'Macaca mulatta', 'Male', 'Microglia', 'Motor Cortex', 'Neurons', 'Osteopontin', 'Pyramidal Tracts', 'RNA, Messenger']
| 30,790,559
|
[['B01.050'], ['D09.698.735.200.625', 'D12.776.395.550.200.625.144', 'D12.776.395.650.750.281', 'D12.776.543.550.200.625.144', 'D12.776.543.750.705.877.144', 'D23.050.301.350.625.144'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['A08.637.400', 'A11.650.400'], ['A08.186.211.200.885.287.500.270.548', 'A08.186.211.200.885.287.500.814.624'], ['A08.675', 'A11.671'], ['D12.644.276.374.625', 'D12.776.395.700.837', 'D12.776.467.374.625', 'D12.776.860.300.762', 'D23.529.374.625'], ['A08.186.854.300', 'A08.612.380.730'], ['D13.444.735.544']]
|
['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]']
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Effects of low ampicillin concentrations on penicillin sensitive and beta-lactamase producing strains of Neisseria gonorrhoeae.
|
The effects of therapeutic concentrations of ampicillin on non-beta-lactamase and beta-lactamase producing strains of Neisseria gonorrhoeae were studied. A small but significant fraction of bacteria in a gonococcal population was found to respond in a bacteriostatic rather than a bactericidal way upon ampicillin treatment. In agreement with this was the finding of morphologically unaltered cells in the scanning electron microscope after ampicillin exposure. Ampicillin treatment of beta-lactamase producing gonococci caused a significant release of the enzyme into the surrounding growth media. However, initially all beta-lactamase activity was cellbound. The rate of initial ampicillin hydrolysis was much higher in intact cells of N. gonorrhoeae (TEM-1) than in cells of Escherichia coli K-12 (TEM-1). This suggests that the diffusion rate of ampicillin is much higher in the former organism. The viability of gonococci (TEM-1) was unlike E. coli (TEM-1) affected by low concentrations of ampicillin. However, after complete hydrolysis of ampicillin, viable gonococci (probably bacteriostatic reacting cells) were able to initiate new growth. This heterogeneity of the cell population to penicillin killing is probably one reason why beta-lactamase producing gonococci despite a rather low MIC-value to ampicillin cause infections that are not susceptible to therapy by this agent.
|
['Ampicillin', 'Escherichia coli', 'Hydrolysis', 'Neisseria gonorrhoeae', 'Penicillinase', 'Penicillins', 'beta-Lactamases']
| 115,831
|
[]
|
[]
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Neurofibromatosis in pregnancy. Maternal and perinatal outcome.
|
OBJECTIVE: The aim of this study was to assess the maternal and perinatal outcome in pregnant patients with neurofibromatosis (NF).STUDY DESIGN: During the period between January 1994 and December 1996 eight women with NF were delivered at the Soroka University Medical Center. Maternal age, parity, gravidy and ethnic origin were matched with a control group that included 65 healthy parturients out of a total of 31,642 deliveries that occurred in our institution during this period. Maternal outcome and perinatal complications were compared between the two groups.RESULTS: The prevalence of NF during the study period was 1:2434 deliveries. The mean gestational age at delivery was significantly lower in the study group as compared to the control group, 36.8+/-3.3 vs. 39.2+/-1.5 weeks, respectively (P=0.029). The rate of intrauterine growth restriction was significantly higher in the study group, (46.2% vs. 8.95%, respectively, P=0.0005), as well as stillbirth rate (23% vs. 1.5%, respectively, P=0.011) and cesarean section rate (38.5% vs. 7.7%, respectively, P=0.01).CONCLUSION: Patients with NF have an increased risk of perinatal complications. Thus, close antenatal observation at high risk tertiary centers is required.
|
['Adult', 'Birth Weight', 'Case-Control Studies', 'Cesarean Section', 'Female', 'Fetal Death', 'Fetal Growth Retardation', 'Gestational Age', 'Gravidity', 'Humans', 'Hypertension', 'Maternal Age', 'Neurofibromatoses', 'Parity', 'Pregnancy', 'Pregnancy Complications', 'Pregnancy Outcome']
| 10,413,228
|
[['M01.060.116'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E04.520.252.500'], ['C13.703.223', 'C23.550.260.585'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['G07.345.500.325.235.968', 'G08.686.320'], ['G08.686.340', 'G08.686.784.769.213', 'N06.850.490.812.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['G08.686.560', 'N05.715.350.075.550', 'N06.850.490.250.550'], ['C04.557.580.600.580.590', 'C04.700.631', 'C10.562.600', 'C10.574.500.549', 'C16.320.400.560', 'C16.320.700.633'], ['G08.686.677', 'G08.686.784.769.472', 'N06.850.490.812.600'], ['G08.686.784.769'], ['C13.703'], ['E01.789.700', 'G08.686.784.769.496']]
|
['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]']
| 0
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Molecular mechanisms of the coordination between astaxanthin and fatty acid biosynthesis in Haematococcus pluvialis (Chlorophyceae).
|
Astaxanthin, a red ketocarotenoid with strong antioxidant activity and high commercial value, possesses important physiological functions in astaxanthin-producing microalgae. The green microalga Haematococcus pluvialis accumulates up to 4% fatty acid-esterified astaxanthin (by dry weight), and is used as a model species for exploring astaxanthin biosynthesis in unicellular photosynthetic organisms. Although coordination of astaxanthin and fatty acid biosynthesis in a stoichiometric fashion was observed in H. pluvialis, the interaction mechanism is unclear. Here we dissected the molecular mechanism underlying coordination between the two pathways in H. pluvialis. Our results eliminated possible coordination of this inter-dependence at the transcriptional level, and showed that this interaction was feedback-coordinated at the metabolite level. In vivo and in vitro experiments indicated that astaxanthin esterification drove the formation and accumulation of astaxanthin. We further showed that both free astaxanthin biosynthesis and esterification occurred in the endoplasmic reticulum, and that certain diacylglycerol acyltransferases may be the candidate enzymes catalyzing astaxanthin esterification. A model of astaxanthin biosynthesis in H. pluvialis was subsequently proposed. These findings provide further insights into astaxanthin biosynthesis in H. pluvialis.
|
['Algal Proteins', 'Chlorophyta', 'Diacylglycerol O-Acyltransferase', 'Endoplasmic Reticulum', 'Esterification', 'Fatty Acids', 'Metabolic Networks and Pathways', 'Microalgae', 'Transcription, Genetic', 'Xanthophylls']
| 25,353,310
|
[['D12.776.037'], ['B01.650.940.150'], ['D08.811.913.050.387'], ['A11.284.430.214.190.875.248'], ['G02.111.270', 'G02.607.250', 'G03.344'], ['D10.251'], ['G03.493'], ['B05.080.500.600.500'], ['G02.111.873', 'G05.297.700'], ['D02.455.326.271.665.202.868', 'D02.455.426.392.368.367.379.249.887', 'D02.455.849.131.868', 'D23.767.261.887']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]']
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Bidirectional expression units enable streptogramin-adjustable gene expression in mammalian cells.
|
Serious initiatives in gene therapy and tissue engineering require a sophisticated molecular toolbox combining DNA transfer technologies, human-compatible transcription control systems, as well as compact and robust expression configurations. We have designed several versatile bidirectional expression cassettes that enable coadjustable expression of two desired transgenes in response to clinically licensed antibiotics of the streptogramin class (pristinamycin, Pyostacin, Synercid). The bidirectional expression modules consist of a central operator (PIR) that is specific for the pristinamycin-dependent transactivator (PIT). Streptogramin-adjustable binding of PIT to PIR transactivates two divergently oriented promoters and initiates transcription of the desired transgenes. The bidirectional expression module can be equipped with different minimal promoters and configured for expression of (1) two functional effector genes, (2) one effector gene and a reporter gene, (3) PIT and an effector gene to form a highly compact one-vector expression arrangement. We have validated the streptogramin-adjustable bidirectional expression technology in different basic and autoregulated expression configurations in a variety of mammalian and human cell lines.
|
['Alkaline Phosphatase', 'Animals', 'Anti-Bacterial Agents', 'Cloning, Molecular', 'Cricetinae', 'Cricetulus', 'Dose-Response Relationship, Drug', 'Gene Expression Regulation', 'Genetic Engineering', 'Mammals', 'Pristinamycin', 'Promoter Regions, Genetic', 'Streptogramins', 'Transcriptional Activation', 'Transfection']
| 12,827,704
|
[['D08.811.277.352.650.035'], ['B01.050'], ['D27.505.954.122.085'], ['E05.393.220'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['G07.690.773.875', 'G07.690.936.500'], ['G05.308'], ['E05.393.420'], ['B01.050.150.900.649'], ['D04.345.566.802.374', 'D12.644.641.802.374'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D04.345.566.802', 'D12.644.641.802'], ['G05.308.800'], ['E05.393.350.810', 'G05.728.860']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]']
| 0
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Prospect for characterizing interacting soft colloidal structures using spin-echo small angle neutron scattering.
|
Spin-echo small angle neutron scattering (SESANS) provides a new experimental tool for structural investigation. Due to the action of spin-echo encoding, SESANS measures a spatial correlation function in real space, as opposed to the structure factor S(Q), I(Q), in momentum (Q) space measured by conventional small angle neutron scattering. To establish the usefulness of SESANS in structural characterization, particularly for interacting colloidal suspensions, we have previously conducted a theoretical study of the SESANS correlation functions for model systems consisting of particles with uniform density profiles [X. Li, C.-Y. Shew, Y. Liu, R. Pynn, E. Liu, K. W. Herwig, G. S. Smith, J. L. Robertson, and W.-R. Chen J. Chem. Phys. 132, 174509 (2010)]. Within the same framework, we explore in the present paper the prospect of using SESANS to investigate the structural characteristics of colloidal systems consisting of particles with nonuniform intraparticle mass distribution. As an example, a Gaussian model of interacting soft colloids is used to investigate the manifestation of structural softness in a SESANS measurement. The exploration shows a characteristically different SESANS correlation function for interacting soft colloids, in comparison to that of a uniform hard sphere system. The difference arises from the Abel transform imbedded in the mathematical formalism bridging the SESANS spectra and the spatial autocorrelation function.
|
['Colloids', 'Molecular Structure', 'Neutron Diffraction', 'Scattering, Small Angle']
| 21,384,982
|
[['D20.280', 'D26.255.165'], ['G02.111.570', 'G02.466'], ['E05.196.309.555', 'E05.196.822.650', 'G01.867.650', 'G02.551'], ['E05.196.822.830', 'G01.867.755']]
|
['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 0
| 0
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Gorilloflasca africana n.g., n.sp., (Entodiniomorphida) from wild habituated Virunga mountain gorillas (Gorilla beringei beringei) in Rwanda.
|
A new entodiniomorphid ciliate species, Gorilloflasca africana n. g., n. sp. was described from the Virunga mountain gorillas, Gorilla beringei beringei, in Rwanda. It is characterized by a flask-shaped body, a long tubular vestibulum, a round frontal lobe, a large posterior cavity, an ellipsoidal or peanut-shaped macronucleus and a single contractile vacuole. G. africana has the adoral and the vestibular ciliary zones in the buccal area. The adoral ciliary zone is non-retractable, encircling the vestibular opening. The vestibular ciliary zone extends posteriorly in the vestibulum. The somatic ciliary zones are the cavity ciliary zone in the posterior cavity along the ventral side of its opening and two longitudinal ciliary zones on the dorsal body surface. The buccal infraciliary bands of G. africana are a C-shaped adoral polybrachykinety, a stick-shaped vestibular kinety band, and paralabial kineties. The anterior region of the vestibular kinety band is composed of short kineties whereas, kineties in the remaining region are longitudinal. The somatic infraciliary bands are a cavity polybrachykinety and two longitudinal polybrachykineties. Gorilloflasca is a member of the family Blepharocorythidae based on the non-retractable adoral ciliary zone, the frontal lobe, the large posterior cavity and the vestibular longitudinal kineties.
|
['Animals', 'Ciliophora', 'Feces', 'Gorilla gorilla', 'Rwanda', 'Species Specificity']
| 28,662,494
|
[['B01.050'], ['B01.043.185'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.375'], ['Z01.058.290.120.680'], ['G16.824']]
|
['Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Phenomena and Processes [G]']
| 1
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
|
Unusual case of granular lymphocytes (GL) proliferation: simultaneous reactive and neoplastic proliferation.
|
We report a case of a 55-year-old male with lymphoproliferative disease of granular lymphocytes. In the first year of follow-up reactive expansion of granular lymphocytes was observed during infectious episodes additionally to malignant proliferation. Histopathological studies revealed malignant lymphocytic infiltrations of the liver and gallbladder walls. The number of GL varied from 1.1 G/l to 17.8 G/l. Immunophenotyping studies showed surface phenotype CD3+, CD8+. There was markedly reduced NK cell function. The patient exhibited lack of severe parenchymal involvement, moderately increased white cell count (up to 21.0 G/l), severe neutropenia (0.06 G/l - 0.8 G/l) and recurrent infectious episodes.
|
['Azure Stains', 'Cell Division', 'Cytoplasmic Granules', 'Gallbladder', 'Gallbladder Neoplasms', 'Humans', 'Leukocyte Count', 'Liver', 'Liver Neoplasms', 'Lymphocytes', 'Lymphocytosis', 'Male', 'Middle Aged', 'Staining and Labeling']
| 1,283,283
|
[['D02.886.369.080', 'D03.633.300.783.080'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['A03.159.439'], ['C04.588.274.120.401', 'C06.130.320.401', 'C06.130.564.401', 'C06.301.120.401'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.200.625.107.595', 'E05.242.195.107.595', 'G04.140.107.595', 'G09.188.105.595'], ['A03.620'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['C15.378.553.475.604'], ['M01.060.116.630'], ['E01.370.225.500.620.670', 'E01.370.225.750.600.670', 'E05.200.500.620.670', 'E05.200.750.600.670']]
|
['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
A report on the use of five bubble oxygenators for cardiopulmonary bypass surgery.
|
Bubble oxygenators available for cardiopulmonary bypass vary in design and in price. Choice of oxygenator is often made on the basis of price, or an empirical assessment of performance. This paper reports our clinical experience with five "hard shell" bubble oxygenators--Harvey H 1500, Harvey H 1000, Shiley S100A, Cobe Optiflo II and Bentley BOS 10. Data relating to gas transfer, heat exchanger performance, haematological changes and oxygenator design is presented and some comparisons made.
|
['Adult', 'Blood Gas Analysis', 'Cardiopulmonary Bypass', 'Female', 'Heart Valve Prosthesis', 'Hemoglobins', 'Humans', 'Male', 'Oxygenators', 'Platelet Count', 'Quality Control']
| 7,065,394
|
[['M01.060.116'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['E04.292.413'], ['E07.695.310'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.652'], ['E01.370.225.500.195.107.740', 'E01.370.225.625.107.700', 'E01.370.225.625.625.625', 'E05.200.500.195.107.740', 'E05.200.625.107.700', 'E05.200.625.625.625', 'E05.242.195.107.740', 'G04.140.107.740', 'G09.188.105.700'], ['J01.897.608']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]']
| 0
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 1
| 0
| 0
|
Interaction of tyrosine 151 in norepinephrine transporter with the 2â group of cocaine analog RTI-113.
|
Cocaine binds and inhibits dopamine transporter (DAT), norepinephrine transporter (NET) and serotonin transporter. The residues forming cocaine binding sites are unknown. RTI-113, a cocaine analog, is 100? more potent at inhibiting DAT than inhibiting NET. Here we show that removing the hydroxyl group from residue Tyr151 in NET by replacing it with Phe, the corresponding residue in DAT, increased the sensitivity of NET to RTI-113, while the reverse mutation in DAT decreased the sensitivity of DAT to RTI-113. In contrast, RTI-31, another cocaine analog having the same structure as RTI-113 but with the phenyl group at the 2â position replaced by a methyl group, inhibits the transporter mutants equally well whether a hydroxyl group is present at the residue or not. The data suggest that this residue contributes to cocaine binding site and is close to the 2â position of cocaine analogs. These results are consistent with our previously proposed cocaine-DAT binding model where cocaine initially binds to a site that does not overlap with, but is close to, the dopamine-binding site. Computational modeling and molecular docking yielded a binding model that explains the observed changes in RTI-113 inhibition potencies.
|
['Animals', 'Cells, Cultured', 'Cocaine', 'Dopamine Plasma Membrane Transport Proteins', 'Dose-Response Relationship, Drug', 'HeLa Cells', 'Humans', 'Mice', 'Norepinephrine Plasma Membrane Transport Proteins', 'Protein Binding', 'Protein Structure, Secondary', 'Random Allocation', 'Tyrosine']
| 21,420,984
|
[['B01.050'], ['A11.251'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['D12.776.157.530.450.625.124', 'D12.776.157.530.562.374.500.500', 'D12.776.157.530.937.500', 'D12.776.543.585.450.625.124', 'D12.776.543.585.562.374.500.500', 'D12.776.543.585.937.500'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.157.530.450.625.186', 'D12.776.157.530.562.374.500.750', 'D12.776.157.530.937.600', 'D12.776.543.585.450.625.186', 'D12.776.543.585.562.374.500.750', 'D12.776.543.585.937.700'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709.600'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], ['D12.125.072.050.875']]
|
['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 0
|
Office removal of tibial external fixators: an evaluation of cost savings and patient satisfaction.
|
OBJECTIVES: To evaluate the efficacy and patient satisfaction of office removal of tibial external fixators and to compare the cost of this procedure with the cost of removal of fixators in the operating room.DESIGN: A visual analog scale (VAS) and a questionnaire were answered by all patients after office external fixator removal. The treatment, complications, and costs were compared with those of patients having external fixator removal in the operating suite.SETTING: An urban orthopaedic trauma office with a Level I trauma center.PARTICIPANTS: Two similar groups of patients; thirty fixators removed in the office and twenty-nine fixators removed in the operating room.INTERVENTION: Office or operating room removal of tibial external fixators and application of a sterile dressing. A visual analog scale was answered by those patients who had office removal.MAIN OUTCOME MEASUREMENTS: Patient satisfaction and pain rating (VAS) with office removal of external fixators. Comparison of costs, infections, time in fixator, and surgical interventions between the office and operating room groups.RESULTS: Group I had thirty fixators (twenty-nine half-pin fixators) removed in the office. Group II had twenty-nine fixators removed in the operating room. Duration of time in the frame was not statistically different. Antibiotic usage during the fixator treatment period was 69 percent in both groups. On the visual analog scale, twenty-four members (80 percent) of the office fixator removal group rated the pain during removal as less than 25 percent of maximal, including nine (30 percent) who rated the removal as causing no pain. Cost analysis revealed an average cost of $248 for the office group versus $2,160 for the operating room group (p < 0.001).CONCLUSIONS: Due to the cost savings and patient satisfaction, without compromising clinical care, the office is our preferred location for tibial half-pin external fixator removal.
|
['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Ambulatory Care', 'Cost Savings', 'Evaluation Studies as Topic', 'External Fixators', 'Fees, Medical', 'Female', 'Hospital Charges', 'Humans', 'Male', 'Middle Aged', 'Office Visits', 'Ohio', 'Operating Rooms', 'Patient Satisfaction', 'Tibial Fractures', 'Treatment Outcome']
| 9,840,791
|
[['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.760.106', 'N02.421.585.106'], ['N03.219.151.160.200'], ['E05.337', 'N05.715.360.335'], ['E07.858.442.660.430', 'E07.858.690.725.430'], ['N03.219.300.426', 'N03.219.442.426'], ['N03.219.262.300', 'N03.219.442.613'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N04.452.758.635'], ['Z01.107.567.875.075.512', 'Z01.107.567.875.350.540', 'Z01.107.567.875.510.540'], ['N02.278.388.700'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', 'N05.300.150.800.625', 'N05.715.360.600'], ['C26.404.875', 'C26.558.857'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Diseases [C]']
| 0
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 1
|
[Problems with carrying out the communalization of reference intervals: from the results of a questionnaire survey sent out by the Society of the Hitachi Automatic Clinical Analyzer].
|
The measurement systems in clinical laboratory tests are being standardized, and variations in measurement values such as those of clinical chemistry tests among institutions have decreased. Though the compatibility of clinical tests' values is being established, reference intervals differ among institutions. Therefore, to clarify problems for the standardization of reference intervals, the Society of the Hitachi Automatic Clinical Analyzer sent out a questionnaire survey on problems regarding standardization in institutions. The questionnaire consisted of 40 items relating to blood examination, clinical chemistry tests, and immunological examination. 27 institutions responded. The results of the questionnaire showed that many institutions look favorably upon the standardization of reference intervals. However, they had a cautious attitude regarding the establishment of the reference intervals for items showing differences in reactivity among reagent kits or having no wide-spread measurement system. They appeared to consider that the standardization process is accompanied by many difficulties. Unless the nationwide standardization of reference intervals is achieved at the scientific society level, approval on the clinical side may be difficult to obtain. How to obtain clinical understanding is a problem. Nationwide data sharing has been advanced, and the standardization of reference intervals should also be advanced at the national level.
|
['Clinical Laboratory Techniques', 'Japan', 'Reference Standards', 'Societies, Scientific', 'Surveys and Questionnaires']
| 19,860,209
|
[['E01.370.225', 'E05.200'], ['Z01.252.474.463', 'Z01.639.595'], ['E05.978.808'], ['N03.540.828.838'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]']
| 0
| 0
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
|
[Study on the initial processing of Corydalis yanhusuo].
|
OBJECTIVE: To establish initial processing technology of Corydalis yanhusuo.METHODS: Investigated the effect of the factors such as slice method, dry method, drying temperature on the content of water-extract, ethanol-extract, effective component in Corydalis yanhusuo pieces. Compared the quality with that of the traditional initial processing samples.RESULTS: The best initial process method was: cut fresh Corydalis yanhusuo into 4 - 5 mm thick slices, dry at 70 - 80 degrees C or microwave dry.CONCLUSION: The study provides theoretical base for modifying the initial processing.
|
['Alkaloids', 'Berberine Alkaloids', 'Chromatography, High Pressure Liquid', 'Corydalis', 'Desiccation', 'Ethanol', 'Microwaves', 'Plant Extracts', 'Plants, Medicinal', 'Quality Control', 'Reproducibility of Results', 'Rhizome', 'Technology, Pharmaceutical']
| 22,066,395
|
[['D03.132'], ['D03.132.098.057', 'D03.633.400.168'], ['E05.196.181.400.300'], ['B01.650.940.800.575.912.250.836.500.312'], ['E05.196.335', 'G02.176'], ['D02.033.375'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['D20.215.784.500', 'D26.667'], ['B01.650.560'], ['J01.897.608'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['A18.024.937.750', 'A18.400.750'], ['E05.916', 'J01.897.836']]
|
['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Anatomy [A]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 0
|
[The effect of egg white on the phospholipid level in blood plasma, erythrocytes and beta-lipoproteins of healthy children].
|
A single taking by children of eggs' white in an amount of 2 g/kg of the body weight resulted in that the blood plasma experienced a decline in the relative content of phosphatidylserine, lecithin and a rise in the level of phosphatidylethanolamine. In the membranes of erythrocytes there occurred a rise in the proportion of phosphatidylserine, phosphatidylethanolamine and a fall of the share of lecithin and sphyngomyelin. In the composition of beta-lipoproteins the level of phosphatidylethanolamine was up with a marked drop of phosphatidylserine. Variations in the content of sphyngomyelin and lecithin showed no characteristic features.
|
['Child', 'Egg White', 'Erythrocytes', 'Humans', 'Lipoproteins, LDL', 'Membranes', 'Phosphatidylcholines', 'Phosphatidylethanolamines', 'Phosphatidylserines', 'Phospholipids', 'Sphingomyelins']
| 174,318
|
[['M01.060.406'], ['G07.203.300.470.700', 'J02.500.470.700'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.532.515', 'D12.776.521.550'], ['A10.615'], ['D10.570.755.375.760.400.800'], ['D10.570.755.375.760.400.840'], ['D10.570.755.375.760.400.971'], ['D10.570.755'], ['D09.400.410.420.525.870', 'D10.390.470.675.870', 'D10.570.755.893', 'D10.570.877.360.612.870']]
|
['Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]']
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 0
| 1
| 0
| 0
|
Diffuse axonal injury: detection of changes in anisotropy of water diffusion by diffusion-weighted imaging.
|
Myelinated axons of white matter demonstrate prominent directional differences in water diffusion. We performed diffusion-weighted imaging on ten patients with head injury to explore the feasibility of using water diffusion anisotropy for quantitating diffuse axonal injury. We showed significant decrease in diffusion anisotropy indices in areas with or without signal abnormality on T2 and T2*-weighted images. We conclude that the water diffusion anisotropy index a potentially useful, sensitive and quantitative way of diagnosing and assessing patients with diffuse axonal injury.
|
['Adult', 'Anisotropy', 'Brain', 'Diffuse Axonal Injury', 'Diffusion Magnetic Resonance Imaging', 'Female', 'Humans', 'Male', 'Water']
| 12,525,952
|
[['M01.060.116'], ['G01.590.040', 'G02.050'], ['A08.186.211'], ['C10.228.140.199.388.500', 'C10.900.300.087.219.500', 'C26.915.300.200.188.500'], ['E01.370.350.825.500.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']]
|
['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
The cost-effectiveness of dulaglutide versus insulin glargine for the treatment of type 2 diabetes mellitus in Japan.
|
AIMS: Dulaglutide is a new once weekly glucagon-like peptide-1 (GLP-1) receptor agonist administered via a disposable auto-injection pen for the management of type 2 diabetes mellitus (T2DM). The objective of this study was to estimate the cost-effectiveness of dulaglutide vs insulin glargine for the management of T2DM from a Japanese healthcare perspective, in accordance with recently approved Japanese Cost-Effectiveness Guidelines.METHODS: The IQVIA CORE Diabetes Model (version 9) was used to estimate the long-term costs and effects of treatment with dulaglutide and insulin glargine. Direct comparative data from the Araki 2015 trial (NCT01584232) was used to inform the analysis. Costs associated with treatment and complications were derived from Japanese sources wherever possible and inflated to 2015 Japanese Yen (JPY). Utilities were based upon a European systematic review of diabetes utilities and adjusted for use in a Japanese population. One-way and probabilistic sensitivity analyses (OWSA and PSA) were conducted on all inputs and key modeling assumptions.RESULTS: Dulaglutide 0.75 mg was associated with higher quality-adjusted life years (QALYs), life years (LYs), and total costs, compared to insulin glargine, resulting in an incremental cost-effectiveness ratio (ICER) of 416,280 JPY/QALY gained. Treatment with dulaglutide increased the time alive and free from diabetes-related complications by 4 months. OWSA and PSA indicated that results were robust to plausible variations in input parameters and modeling assumptions.LIMITATIONS: Key limitations of this study are similar to other cost-utility analyses of diabetes, including the extrapolation of short-term clinical trial data into lifelong durations. In addition, due to the lack of robust published Japanese data, some values were derived from non-Japanese sources.CONCLUSIONS: This analysis suggests that dulaglutide 0.75 mg may be a cost-effective treatment alternative to insulin glargine for patients with T2DM in Japan.
|
['Adult', 'Aged', 'Body Mass Index', 'Cost-Benefit Analysis', 'Diabetes Complications', 'Diabetes Mellitus, Type 2', 'Disease Progression', 'Female', 'Glucagon-Like Peptides', 'Glycated Hemoglobin A', 'Health Behavior', 'Health Expenditures', 'Humans', 'Hypoglycemic Agents', 'Immunoglobulin Fc Fragments', 'Insulin Glargine', 'Japan', 'Life Expectancy', 'Lipids', 'Male', 'Middle Aged', 'Models, Econometric', 'Quality of Life', 'Quality-Adjusted Life Years', 'Recombinant Fusion Proteins']
| 29,357,718
|
[['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['N03.219.151.125'], ['C19.246.099'], ['C18.452.394.750.149', 'C19.246.300'], ['C23.550.291.656'], ['D06.472.317.680.500'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381', 'D12.776.422.316.762.380.440'], ['F01.145.488'], ['N03.219.151.450', 'N05.300.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'], ['D12.644.541.500.697', 'D12.776.124.486.485.538.500', 'D12.776.124.486.485.680.697', 'D12.776.124.790.651.538.500', 'D12.776.124.790.651.680.660', 'D12.776.377.715.548.538.500', 'D12.776.377.715.548.680.660'], ['D06.472.699.587.200.300.100', 'D12.644.548.586.200.300.100'], ['Z01.252.474.463', 'Z01.639.595'], ['E05.318.308.985.450', 'N01.224.935.464', 'N06.850.505.400.975.450', 'N06.850.520.308.985.450'], ['D10'], ['M01.060.116.630'], ['E05.318.740.500.600.500', 'E05.599.835.890.500', 'N05.715.360.750.530.500.500', 'N06.850.520.830.500.600.500'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E05.318.740.100.500.700', 'N01.224.935.530.700'], ['D12.776.828.300']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]']
| 0
| 1
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 1
| 1
|
Outbreak of cholera due to Vibrio cholerae 01 in Orissa state.
|
During May-June 1993, an outbreak of acute diarrhoea resulting in deaths primarily in adults was reported in two districts of Orissa state. Epidemiological and microbiological investigations revealed that this outbreak was caused by V. cholerae 01 biotype EITor. V. cholerae 01 strains were uniformly resistant to furazolidone.
|
['Adult', 'Cholera', 'Disease Outbreaks', 'Humans', 'India']
| 7,829,153
|
[['M01.060.116'], ['C01.150.252.400.959.347'], ['N06.850.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393']]
|
['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]']
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 1
|
The Pritchard ERS total elbow prosthesis: lessons to be learned from failure.
|
BACKGROUND: Documentation of the long-term effectiveness of 3-part unlinked elbow replacement is limited. The value of replacing the radial humeral articulation has not been addressed to any extent in the currently available literature.MATERIALS: A retrospective study of patient charts and radiographs of 37 patients receiving 46 primary Pritchard ERS arthroplasties between 1983 and 1992 were reviewed. Thirty-two implants (70%) failed after an average of 83 months (range, 0-198). Causes of failure were analyzed in detail.RESULTS: Kaplan Meier survivor analysis showed a 10-year survival of 54% (confidence interval: 40-71%). Main reasons for failure were instability, wear, and loosening. Immediate postoperative radiographs showed ulnohumeral malposition (valgus or varus) in 19 elbows, which directly correlated to subsequent failure. While this design has proven to be unsuccessful, it does document the need for precise technique and highlights the issue of replacing the radio/capitellar joint in future designs deserves further study.CONCLUSION: An explanation of these disappointing outcomes resides both in an inadequate design and a poorly understood and executed surgical technique. The value of refined instrumentation to allow accurate and reproducible component implantation and soft tissue balancing is highlighted. These considerations are particularly relevant if the radial head component is to be used.
|
['Adult', 'Aged', 'Arthritis, Rheumatoid', 'Arthroplasty, Replacement', 'Elbow Joint', 'Equipment Failure Analysis', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Intraoperative Complications', 'Joint Instability', 'Joint Prosthesis', 'Kaplan-Meier Estimate', 'Male', 'Osteoarthritis', 'Probability', 'Prosthesis Design', 'Prosthesis Failure', 'Radiography', 'Radius', 'Reoperation', 'Retrospective Studies', 'Risk Assessment', 'Time Factors', 'Treatment Outcome']
| 19,278,876
|
[['M01.060.116'], ['M01.060.116.100'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E04.555.110.110', 'E04.650.110', 'E04.680.101.110'], ['A02.835.583.290'], ['E05.325.192'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C23.550.505'], ['C05.550.521'], ['E07.695.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['C05.550.114.606', 'C05.799.613'], ['E05.318.740.600', 'G17.680', 'N05.715.360.750.625', 'N06.850.520.830.600'], ['E05.320.550', 'E07.695.680'], ['C23.550.767.865', 'E05.325.771'], ['E01.370.350.700'], ['A02.835.232.087.090.700'], ['E04.690'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['G01.910.857'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]']
| 1
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
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