Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
15-Azasteroid blockage of cell permeability and mitochondrial respiration. | The 15-azasteroid, 1,10,11,11a-tetrahydro-11a-methyl-2H naphth (1,2-g)indol-7-o1, inhibits the growth of the cell culture lines KB and L-M as well as several strains of bacteria. The inhibition of growth is reversed following removal of the steroid from the growth medium. Using in vitro grown L-M cells, the compound in... | ['Alanine', 'Aminoisobutyric Acids', 'Animals', 'Azasteroids', 'Azides', 'Biological Transport, Active', 'Cell Line', 'Cell Membrane Permeability', 'Imines', 'Kinetics', 'Leucine', 'Male', 'Mitochondria, Liver', 'Oxygen Consumption', 'Rats', 'Steroids, Heterocyclic'] | 1,006,723 | [['D12.125.042'], ['D02.241.081.114.968.249', 'D12.125.070.075', 'D12.125.190.055'], ['B01.050'], ['D04.210.500.925.100'], ['D01.625.100', 'D02.159'], ['G03.143.310'], ['A11.251.210'], ['G03.143.335', 'G04.175'], ['D02.491'], ['G01.374.661', 'G02.111.490'], ['D12.125.070.637', 'D12.125.142.441'], ['A11.284.430.214.190.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis of (2S,3S)-[3-(2)H1]-4-methyleneglutamic acid and (2S,3R)-[2,3-(2)H2]-4-methyleneglutamic acid. | (2S,3S)-[3-(2)H1]-4-Methyleneglutamic acid 1a and (2S,3R)-[2,3-(2)H2]-4-methyleneglutamic acid 1b have been synthesised for use in biosynthetic and metabolic studies. | ['Glutamates', 'Glutamic Acid', 'Molecular Structure'] | 16,604,216 | [['D12.125.067.625', 'D12.125.119.409'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['G02.111.570', 'G02.466']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Information decay in molecular docking screens against holo, apo, and modeled conformations of enzymes. | Molecular docking uses the three-dimensional structure of a receptor to screen a small molecule database for potential ligands. The dependence of docking screens on the conformation of the binding site remains an open question. To evaluate the information loss that occurs as the active site conformation becomes less de... | ['Animals', 'Apoenzymes', 'Binding Sites', 'Crystallography, X-Ray', 'Databases, Protein', 'Enzymes', 'Holoenzymes', 'Humans', 'Ligands', 'Models, Molecular', 'Protein Binding', 'Protein Conformation', 'Quantitative Structure-Activity Relationship'] | 12,825,931 | [['B01.050'], ['D08.811.255.500', 'D12.776.070.290'], ['G02.111.570.120'], ['E05.196.309.742.225'], ['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['D08.811'], ['D08.811.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Bilateral trochlear nerve palsy subsequent to ventriculoperitoneal shunting of normal pressure hydrocephalus. | Misplacement of the ventricular catheters of shunt systems may result in shunt dysfunction or a variety of neurological symptoms. Bilateral fourth nerve palsy has not been reported thus far after shunting. Here, we describe the occurrence of this unusual neurological deficit in a patient who underwent shunting for norm... | ['Aged, 80 and over', 'Headache Disorders', 'Humans', 'Hydrocephalus, Normal Pressure', 'Male', 'Tomography, X-Ray Computed', 'Trochlear Nerve Diseases', 'Ventriculoperitoneal Shunt'] | 21,815,738 | [['M01.060.116.100.080'], ['C10.228.140.546'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.602.750'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['C10.292.850'], ['E04.035.188.850', 'E04.525.170.850']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Determination of Se(IV) and Se(VI) in Italian mineral waters. | This paper deals with determination of selenium and analysis of its speciation in some Italian mineral waters. Selenium was determined by differential pulse cathodic stripping voltammetry (DPCSV) even if square wave cathodic stripping voltammetry (SWCSV) was also taken into consideration. The selenium determined in the... | ['Beverages', 'Italy', 'Polarography', 'Selenium', 'Water'] | 17,217,169 | [['G07.203.100', 'J02.200'], ['Z01.542.489'], ['E05.196.749', 'E05.301.700'], ['D01.268.185.850', 'D01.578.700'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
The movement of pyruvate, lactate and lactate dehydrogenase into rabbit oviductal fluid. | Pyruvate, lactate and lactate dehydrogenase appeared linearly in 2 ml 0.9% NaCl recirculated through the rabbit oviduct for 4 h in vivo. In oviducts from rabbits injected 3 days previously with 100 i.u. hCG, the rate of appearance of all three constituents was considerably reduced. It is considered unlikely that the la... | ['Animals', 'Biological Transport', 'Body Fluids', 'Fallopian Tubes', 'Female', 'L-Lactate Dehydrogenase', 'Lactates', 'Pyruvates', 'Rabbits'] | 480,313 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Late diagnosis of spinal dural arteriovenous fistulas resulting in severe lower-extremity weakness: a case series. | BACKGROUND CONTEXT: Spinal dural arteriovenous fistula (SDAVF) is a slow-flow extramedullary vascular lesion affecting primarily the lower thoracic and lumbar spine. The clinical sequela of these vascular changes is progressive myelopathy and severe lower-extremity weakness. Although surgical or embolic treatment of SD... | ['Adult', 'Aged', 'Central Nervous System Vascular Malformations', 'Delayed Diagnosis', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Retrospective Studies', 'Spinal Cord Diseases'] | 24,246,747 | [['M01.060.116'], ['M01.060.116.100'], ['C10.500.190', 'C14.240.850.875', 'C16.131.240.850.875', 'C16.131.666.190'], ['E01.110', 'E02.760.273', 'N02.421.585.273'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.7... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Drug-induced changes in selenium-dependent glutathione peroxidase activity in the chick. | The ability of aurothioglucose and D(-)-penicillamine hydrochloride to inhibit selenium-dependent glutathione peroxidase (SeGSH-Px) in vitro and to increase exudative diathesis in vitamin E-deficient chickens was studied. Aurothioglucose and penicillamine competitively inhibited SeGSH-Px in inverse proportion to the co... | ['Administration, Oral', 'Animals', 'Aurothioglucose', 'Catalase', 'Chickens', 'Drug Interactions', 'Glutathione Peroxidase', 'Injections, Subcutaneous', 'Liver', 'Penicillamine', 'Poultry Diseases', 'Selenium', 'Vitamin E Deficiency'] | 3,932,615 | [['E02.319.267.100'], ['B01.050'], ['D02.691.675.249'], ['D08.811.682.732.332'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G07.690.773.968'], ['D08.811.682.732.500'], ['E02.319.267.530.620'], ['A03.620'], ['D02.886.030.786', 'D12.125.166.786'], ['C22.131.728'], ['D01.268.185.850', 'D01.578.700']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Parenchymatous thyroid nodules: a histocytological study of 31 cases from a goitrous area. | AIMS: To analyse the benefits and limitations of fine needle aspiration in the cytological differentiation of parenchymatous nodular goitres from follicular tumours in an endemic area.METHODS: Cytological smears of fine needle aspirates from 31 parenchymatous nodular goitres were studied. A sample from the punctured no... | ['Biopsy, Needle', 'Cell Nucleus', 'Cytoplasm', 'Diagnosis, Differential', 'Goiter, Endemic', 'Goiter, Nodular', 'Humans', 'Thyroid Gland', 'Thyroid Neoplasms'] | 1,740,509 | [['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.214'], ['E01.171'], ['C19.874.283.300'], ['C19.874.283.501'], ['B01... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Taxol directly induces endoplasmic reticulum-associated calcium changes that promote apoptosis in breast cancer cells. | Calcium, a key regulator of cell survival, is also important in regulating apoptosis. Although the chemotherapeutic agent Taxol employs apoptosis to induce cell death, the exact mechanism of how it induces apoptosis and the role of calcium in this process remains unclear. The main intracellular calcium storehouse, the ... | ['Analysis of Variance', 'Antineoplastic Agents, Phytogenic', 'Apoptosis', 'Breast Neoplasms', 'Calcium', 'Cell Line, Tumor', 'Cytosol', 'Dose-Response Relationship, Drug', 'Endoplasmic Reticulum', 'Female', 'Humans', 'Paclitaxel'] | 21,073,601 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D27.505.954.248.179'], ['G04.146.954.035'], ['C04.588.180', 'C17.800.090.500'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['G0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Boosting a teen substance use prevention program with motivational interviewing. | A brief motivational interviewing (MI) intervention may be a viable adjunct to school-based substance abuse prevention programs. This article describes the development and implementation of a brief MI intervention with 573 adolescents (mean age 16.8; 40.3% female, 68% Latino) enrolled in eight continuation high schools... | ['Adolescent', 'California', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Motivation', 'School Health Services', 'Substance-Related Disorders', 'Treatment Outcome', 'Young Adult'] | 22,216,936 | [['M01.060.057'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['F01.658', 'F01.752.543.500.750'], ['N02.421.726.809'], ['C25.775', 'F03.900'], ['E01.789.800', 'N04.761.559.5... | ['Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
How robust is ACTIVLIM for the follow-up of activity limitations in patients with neuromuscular diseases? | This study aims to investigate the clinimetric properties of ACTIVLIM, a measure of activity limitations, when it is used in daily practice in a large nationwide representative cohort of patients with neuromuscular diseases. A cohort of 2986 patients was assessed at least once over 2 years in 6 national neuromuscular d... | ['Activities of Daily Living', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Disability Evaluation', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Neuromuscular Diseases', 'Psychometrics', 'Reproducibility of Results', 'Severity of Illness Index', 'Young Adult'] | 26,826,887 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['E01.370.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.40... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[The clinical aspects of 4 cases of oral Kaposi's sarcoma]. | The authors report 4 cases of patients with AIDS and harbouring oral lesions of Kaposi's sarcoma. They describe the macroscopic appearance and clinical signs in relation to epidemic Kaposi's systemic ones. Because of the anamnestic or coexistence of oral mycosis (Candida), in every case the authors suppose that it may ... | ['AIDS-Related Complex', 'Acquired Immunodeficiency Syndrome', 'Adult', 'Candidiasis, Oral', 'HIV Seropositivity', 'Humans', 'Male', 'Mouth Neoplasms', 'Opportunistic Infections', 'Prognosis', 'Sarcoma, Kaposi'] | 1,803,225 | [['C01.221.250.875.080', 'C01.221.812.640.400.080', 'C01.778.640.400.080', 'C01.925.782.815.616.400.080', 'C01.925.813.400.080', 'C01.925.839.080', 'C20.673.480.080'], ['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Substrate-induced activation of dienelactone hydrolase: an enzyme with a naturally occurring Cys-His-Asp triad. | The Cys-His-Asp catalytic triad found in dienelactone hydrolase (DLH) is unusual for several reasons. It has not been observed in other hydrolytic enzymes and it is virtually inactive when it is produced by site-directed mutagenesis in the proteases. We propose a model to explain why this triad is catalytically active ... | ['Amino Acid Sequence', 'Base Sequence', 'Carboxylic Ester Hydrolases', 'Catalysis', 'Crystallography, X-Ray', 'Enzyme Activation', 'Hydrogen Bonding', 'Lactones', 'Models, Chemical', 'Models, Molecular', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Protein Binding', 'Protein Conformation'] | 8,234,228 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.352.100'], ['G02.130'], ['E05.196.309.742.225'], ['G02.111.263', 'G03.328'], ['G02.282'], ['D02.540'], ['E05.599.495'], ['E05.599.595'], ['L01.453.245.667'], ['E05.393.420.601.575'], ['G02.111.679', 'G0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Flunarizine, a new preventive approach to migraine. A double-blind comparison with placebo. | Seventeen patients with common or classic migraine were prophylactically treated with 10 mg flunarizine daily, whereas 18 patients received a placebo during a 12-week randomized double-blind study. In the gross flunarizine was significantly superior to the placebo. Only 3 patients felt that flunarizine had been useless... | ['Adult', 'Cinnarizine', 'Clinical Trials as Topic', 'Double-Blind Method', 'Female', 'Flunarizine', 'Humans', 'Male', 'Middle Aged', 'Migraine Disorders', 'Piperazines', 'Random Allocation'] | 6,325,065 | [['M01.060.116'], ['D03.383.606.290'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D03.383.606.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.228.140.546.399.750... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The first two cantharidin analogues displaying PP1 selectivity. | High pressure Diels-Alder reactions of furan and dimethylmaleate, and thiophene and maleimide resulted in two cantharidin analogues, 3 and 6 possessing PP1 selectivity (>40- and >30-fold selectivity) over PP2A. Both compounds exhibited moderate PP1 activity, 3 IC(50) 50 microM and 6 IC(50) 12.5 microM. Interestingly, t... | ['Cantharidin', 'Enzyme Inhibitors', 'Indicators and Reagents', 'Phosphoprotein Phosphatases', 'Structure-Activity Relationship', 'Substrate Specificity'] | 11,814,804 | [['D03.633.100.127.125'], ['D27.505.519.389'], ['D27.720.470.410'], ['D08.811.277.352.650.625'], ['G02.111.830', 'G07.690.773.997'], ['G02.111.835']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular mechanisms of cyclosporin A inhibition of the cytokine-induced matrix metalloproteinase-9 in glomerular mesangial cells. | The effects of the immunosuppressants cyclosporin A (CsA) and tacrolimus (FK506) on the IL-1beta-induced matrix metalloproteinase-9 (MMP-9) were investigated. Impairment of the protease-antiprotease balance contributes to renal fibrosis, which is observed collectively under long-term treatment with either immunosuppres... | ['Animals', 'Cells, Cultured', 'Cyclosporine', 'Cytokines', 'Disease Progression', 'Enzyme Induction', 'Glomerular Mesangium', 'Humans', 'Immunosuppressive Agents', 'Interleukin-1beta', 'Kidney Diseases', 'Matrix Metalloproteinase 9', 'Matrix Metalloproteinase Inhibitors', 'Rats', 'Recombinant Proteins', 'Tacrolimus'] | 17,202,418 | [['B01.050'], ['A11.251'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C23.550.291.656'], ['G05.308.320.200'], ['A05.810.453.324.359.620.500', 'A05.810.453.736.520.620.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['D12.644.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of Brassica oleracea in rats skin wound healing. | PURPOSE: To investigate the effect of Brassica oleracea herbal balsam on the healing of skin wounds in rats.METHODS: Twenty four rats (Wistar, 60 days, 250 g) were divided into four groups: untreated animals (C) and treated with the ointment (T), subdivided into two experimental times (seven and 16 days). A 3cm² skin w... | ['Animals', 'Biometry', 'Brassica', 'Collagen', 'Plant Extracts', 'Rats', 'Rats, Wistar', 'Reproducibility of Results', 'Skin', 'Tensile Strength', 'Time Factors', 'Treatment Outcome', 'Wound Healing'] | 24,000,060 | [['B01.050'], ['E05.318.740.225', 'N06.850.505.200'], ['B01.650.940.800.575.912.250.157.200'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D20.215.784.500', 'D26.667'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bringing the Bottom Billion into Basic Literacy: How We Can and Why We Must. | Close to one billion people in the world do not have basic literacy skills. A key challenge is reaching children in the midst of circumstances that make a traditional school-based approach impractical. This chapter will describe a cross-disciplinary, mobile technology approach to literacy education. The Curious Learnin... | ['Child', 'Child, Preschool', 'Computer-Assisted Instruction', 'Developing Countries', 'Ethiopia', 'Humans', 'India', 'Learning', 'Literacy', 'Mobile Applications', 'Outcome Assessment, Health Care', 'South Africa', 'Uganda', 'United States'] | 29,243,382 | [['M01.060.406'], ['M01.060.406.448'], ['I02.903.771.500.208'], ['I01.615.500.300'], ['Z01.058.290.120.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['F02.463.425', 'F02.784.629.529'], ['F01.145.209.429', 'N01.824.196.500'], ['L01.224.900.685'], ['H01.770.644.145.431', 'N04.761.559.590', ... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Microleakage: the effect of storage and cycling duration. | This investigation revealed that the limited storage time or cycling durations used had no significant impact on the microleakage patterns of a resin-bonded composite in Class V preparations. Short-term cycling appears as effective in demonstrating marginal leakage as protracted cycling regimens. These findings may be ... | ['Composite Resins', 'Dental Leakage', 'Dental Restoration, Permanent', 'Humans', 'Periodicity', 'Time Factors'] | 3,474,404 | [['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['C07.793.221'], ['E06.323.428', 'E06.780.346.737', 'E07.695.190.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.910.645', 'G07.180.562'], ['G01.910.857']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Left ventricular function in essential hypertension during isoproterenol infusion]. | The left ventricular function of 23 patients with essential hypertension was investigated during infusion of isoproterenol (ISP). These patients consisted of 13 without cardiac hypertrophy (Group NH) and 10 with cardiac hypertrophy (Group HH). Ten normotensive subjects served as normal controls. To assess left ventricu... | ['Adult', 'Aged', 'Blood Pressure', 'Cardiomegaly', 'Echocardiography', 'Heart', 'Heart Rate', 'Humans', 'Hypertension', 'Isoproterenol', 'Middle Aged', 'Stroke Volume', 'Vascular Resistance'] | 2,942,608 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C14.280.195', 'C23.300.775.250'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['A07.541'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['D02.0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A pediatric case of pigmented epithelioid melanocytoma with chromosomal copy number alterations in 15q and 17q and a novel NTRK3-SCAPER gene fusion. | Pigmented epithelioid melanocytoma (PEM) represents a group of rare, heavily pigmented melanocytic tumors encompassing lesions previously designated as "animal-type melanomas" and "epithelioid blue nevi." Despite the association of multiple such tumors in the setting of Carney complex, most cases of PEM occur spontaneo... | ['Carrier Proteins', 'Child, Preschool', 'Chromosome Aberrations', 'Chromosomes, Human, Pair 15', 'Chromosomes, Human, Pair 17', 'Discoidin Domain Receptor 2', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Nevus, Blue', 'Oncogene Proteins, Fusion', 'Skin Neoplasms'] | 31,437,301 | [['D12.776.157'], ['M01.060.406.448'], ['C23.550.210', 'G05.365.590.175'], ['A11.284.187.520.300.370.385', 'G05.360.162.520.300.370.385'], ['A11.284.187.520.300.415.425', 'G05.360.162.520.300.415.425'], ['D08.811.913.696.620.682.725.400.005.750', 'D12.776.543.750.630.005.750', 'D12.776.543.750.685.050.750', 'D12.776.54... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Computer-assisted analysis of fetal movements in intrauterine growth retardation (IUGR). | A quantitative analysis of various fetal activities (mouth, eye and gross body movements) was made in 10 IUGR human fetuses. The aim of the study was to see whether IUGR fetuses move differently to normal fetuses. Each real-time ultrasound recording lasted 1 h and the analysis of various activities was carried out duri... | ['Eye Movements', 'Female', 'Fetal Growth Retardation', 'Fetal Movement', 'Gestational Age', 'Humans', 'Male', 'Mouth', 'Pregnancy', 'Software', 'Ultrasonography', 'Video Recording'] | 9,605,466 | [['G11.427.410.140', 'G14.350'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['G07.345.500.325.235.374', 'G08.686.784.170.157.374'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.456.505.631', 'A03.556.500', 'A14.549'], ['G08.686.784.769'], ['L01.224.900']... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Adaptability of structured forms for CSII initiation in patients with type 2 diabetes the Getting2Goal(SM) concept. | BACKGROUND: The goal is to assess the usability and satisfaction of implementing the Getting2Goal(SM) protocol by physicians transitioning patients with type 2 diabetes (T2DM) from multiple daily injections (MDI) to continuous subcutaneous insulin infusion (CSII).METHODS: T2DM patients from three diabetes clinics were ... | ['Adaptation, Physiological', 'Aged', 'Blood Glucose', 'Diabetes Mellitus, Type 2', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Hypoglycemic Agents', 'Infusions, Subcutaneous', 'Insulin', 'Insulin Infusion Systems', 'Male', 'Middle Aged', 'Surveys and Questionnaires'] | 26,746,672 | [['G07.025', 'G16.012.500'], ['M01.060.116.100'], ['D09.947.875.359.448.500'], ['C18.452.394.750.149', 'C19.246.300'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381', 'D12.776.422.316.762.380.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'], ['E02.319.267.510.795'], ['D06.47... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cloning and characterization of HEP21, a new member of the uPAR/Ly6 protein superfamily predominantly expressed in hen egg white. | Using two-dimensional (2D)-PAGE, partial protein internal sequencing, and PCR with degenerate primers, we cloned a novel cDNA named HEP21 from hen egg white. The 0.5-kb cDNA encodes a 106 amino acid protein with a cysteine spacing pattern suggesting that HEP21 is a new member of the uPAR/CD59/Ly-6/ snake neurotoxin sup... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Chickens', 'Cloning, Molecular', 'DNA, Complementary', 'Egg Proteins', 'Egg White', 'Electrophoresis, Gel, Two-Dimensional', 'Female', 'Gene Expression', 'Molecular Sequence Data', 'Oviducts', 'Random Amplified Polymorphic DNA Technique', 'Reverse Transcriptase Polym... | 12,619,801 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['D12.776.290'], ['G07.203.300.470.700', 'J... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Assessment of haematotoxic potential of mercuric chloride in rat. | The blood is an important liquid connective tissue flow in body and performs the role of distribution of oxygen to various tissues, taken out carbon dioxide and maintains the health status of an organism. Any change in the blood components can cause adverse effects on the body. The effect of mercuric chloride has been ... | ['Animals', 'Blood', 'Blood Coagulation', 'Blood Sedimentation', 'Erythrocyte Count', 'Erythropoiesis', 'Female', 'Lethal Dose 50', 'Leukocyte Count', 'Male', 'Mercuric Chloride', 'Rats'] | 20,143,731 | [['B01.050'], ['A12.207.152', 'A15.145'], ['G09.188.390.150'], ['E01.370.225.625.125', 'E05.200.625.125'], ['E01.370.225.500.195.107.330', 'E01.370.225.625.107.330', 'E05.200.500.195.107.330', 'E05.200.625.107.330', 'E05.242.195.107.330', 'G04.140.107.330', 'G09.188.105.330'], ['G04.152.825.414', 'G09.188.343.414'], ['... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular and pharmacological evidence for a facilitatory functional role of pre-synaptic GLUK2/3 kainate receptors on GABA release in rat trigeminal caudal nucleus. | BACKGROUND: Gamma-aminobutyric acid (GABA) and glutamate (GLU) are involved in nociceptive signals processing in the trigeminal system. In this study, we investigated the influence of excitatory transmission on GABA release in nerve terminals isolated from the rat trigeminal caudal nucleus (TCN).METHODS: We utilize bio... | ['Animals', 'Excitatory Amino Acid Agonists', 'Kainic Acid', 'Male', 'Neurons', 'Rats', 'Rats, Wistar', 'Receptors, Kainic Acid', 'Synaptic Transmission', 'Synaptosomes', 'Trigeminal Caudal Nucleus', 'gamma-Aminobutyric Acid'] | 22,392,917 | [['B01.050'], ['D27.505.519.625.190.200', 'D27.505.696.577.190.200'], ['D03.383.773.400'], ['A08.675', 'A11.671'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D12.776.157.530.400.400.500.200', 'D12.776.543.550.450.500.200.200', 'D12.776.543.585.400.500.200.200', 'D12.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Beyond the biomedical and behavioural: towards an integrated approach to HIV prevention in the southern African mining industry. | While migrant labour is believed to play an important role in the dynamics of HIV-transmission in many of the countries of southern Africa, little has been written about the way in which HIV/AIDS has been dealt with in the industrial settings in which many migrant workers are employed. This paper takes the gold mining ... | ['Adult', 'Government', 'HIV Infections', 'Health Education', 'Health Services Research', 'Humans', 'Labor Unions', 'Male', 'Mining', 'Sex Education', 'Sexual Behavior', 'South Africa', 'Transients and Migrants'] | 10,400,262 | [['M01.060.116'], ['I01.409', 'N03.540.348'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['I02.233.332', 'N02.421.726.407'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.540.571'... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
Deprivation of pantothenic acid elicits a movement disorder and azoospermia in a mouse model of pantothenate kinase-associated neurodegeneration. | We asked whether a movement disorder could be elicited by deprivation of pantothenic acid (PA; vitamin B5), the substrate for the enzyme pantothenate kinase 2 (PANK2), which is deficient in the inherited neurological disorder PKAN (pantothenate kinase-associated neurodegeneration formerly called Hallervorden-Spatz synd... | ['Animals', 'Azoospermia', 'Disease Models, Animal', 'Growth Disorders', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred Strains', 'Motor Activity', 'Nerve Degeneration', 'Pantothenic Acid', 'Phosphotransferases (Alcohol Group Acceptor)'] | 17,429,753 | [['B01.050'], ['C12.294.365.700.380'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.393'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['F01.145.63... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Attempted suicide in patients with eating disorders. | BACKGROUND: Suicide is a major cause of mortality for patients with eating disorders (ED), especially for patients with anorexia nervosa. Attempted suicide is also relatively common in patients with anorexia or bulimia nervosa.AIMS: This study aimed at examining associations between attempted suicide and trait- and sta... | ['Adolescent', 'Adult', 'Aged', 'Antisocial Personality Disorder', 'Binge-Eating Disorder', 'Feeding and Eating Disorders', 'Female', 'Humans', 'Male', 'Middle Aged', 'Personality', 'Personality Inventory', 'Psychiatric Status Rating Scales', 'Risk Factors', 'Suicide, Attempted', 'Surveys and Questionnaires', 'Young Ad... | 25,231,853 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F03.675.050'], ['F03.400.188'], ['F03.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.752'], ['F04.711.647.513'], ['F04.711.513.653'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.4... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Independence of nurses in the therapeutic team based on dialysis units in region of L?d?]. | UNLABELLED: Professional role of modern nurse requires from her in process of treatment this kind of procedure, which is expected by patient and it is implicated with direction of medical operation. Dependence place of doctor occupies then sense of cooperation. Insufficient independence, making oppositions before decis... | ['Health Knowledge, Attitudes, Practice', 'Patient Care Team', 'Peritoneal Dialysis', 'Poland', 'Population Surveillance', 'Quality of Health Care'] | 19,580,194 | [['F01.100.150.500', 'N05.300.150.410'], ['N04.590.715'], ['E02.870.300.650', 'E02.912.800.650'], ['Z01.542.248.679'], ['E05.318.308.980.438.700', 'N05.715.360.300.800.438.625', 'N06.850.520.308.980.438.700', 'N06.850.780.675'], ['N04.761', 'N05.715']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[CT anatomy of the normal spleen: variants and pitfalls]. | Normally, the spleen is located in the left hypochondrium. It is attached by the gastrosplenic and splenorenal ligaments. Its tissue composition made up of red pulp and white pulp explains the heterogenous aspect when contrast medium is injected in the arterial phase. This can make it difficult to detect intrasplenic m... | ['Adult', 'Aged', 'Choristoma', 'Contrast Media', 'Diagnosis, Differential', 'Female', 'Humans', 'Ligaments', 'Male', 'Middle Aged', 'Radiographic Image Enhancement', 'Spleen', 'Splenic Diseases', 'Splenic Rupture', 'Splenosis', 'Tomography, X-Ray Computed'] | 17,464,253 | [['M01.060.116'], ['M01.060.116.100'], ['C23.300.250'], ['D27.505.259.500', 'D27.720.259'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.513', 'A10.165.669'], ['M01.060.116.630'], ['E01.370.350.600.350.700', 'E01.370.350.700.700', 'L01.224.308.380.600'], ['A10.549.700', 'A15.382.520.604.700'], ['... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Lipoinjection as a treatment of pacemaker pocket neuralgia. | Chronic severe pacemaker pocket neuralgia secondary to inadequate subcutaneous tissue between the pacemaker and overlying skin typically is treated by surgical pocket revision or relocation of the system. A case of this complication successfully treated by lipoinjection is reported. Additional experience is needed to c... | ['Adipose Tissue', 'Aged', 'Defibrillators, Implantable', 'Female', 'Follow-Up Studies', 'Humans', 'Injections', 'Lipectomy', 'Neuralgia', 'Postoperative Complications', 'Prosthesis Implantation', 'Transplantation, Autologous'] | 9,558,698 | [['A10.165.114'], ['M01.060.116.100'], ['E07.305.250.159.175', 'E07.305.250.319.175', 'E07.695.202.175'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530'], ['E02.218.530', 'E02.650.500.062.937', 'E04.062.937',... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The vagueness of "tradition" and the pain and suffering of children. | The argument presented by Jeffrey Bishop that "tradition" justifies female circumcision is grounded on the assumption that reason is always situated within traditions and that traditions are the foundational source of values. I argue that the concept of tradition is inherently vague and, as such, cannot support the wei... | ['Anthropology, Cultural', 'Circumcision, Female', 'Cultural Characteristics', 'Ethics, Medical', 'Female', 'Humans', 'Pain'] | 18,662,952 | [['I01.076.201'], ['E02.218.085.165', 'E04.085.165', 'E04.950.300.200', 'I01.076.201.450.199'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Allosteric activation of latent p53 tetramers. | BACKGROUND: The DNA-binding activity of p53 is essential to its function as a tumour suppressor. Point mutations that abolish this activity have been found to occur frequently in the p53 genes of human cancer cells. Wild-type p53 protein assembles into oligomers with latent DNA-binding activity that can be activated in... | ['Allosteric Regulation', 'Amino Acid Sequence', 'Animals', 'Antibodies, Monoclonal', 'Cell Line', 'DNA', 'Humans', 'Molecular Sequence Data', 'Phosphorylation', 'Tumor Suppressor Protein p53'] | 7,850,419 | [['G02.111.044'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A11.251.210'], ['D13.444.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A missense mutation encoding cys(67) --> gly in neurophysin ii is associated with early onset autosomal dominant neurohypophyseal diabetes insipidus. | Autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) is an inherited disorder in which progressive degeneration of magnocellular neurons of the hypothalamus impairs production of arginine vasopressin (AVP). ADNDI is caused by mutations in the arginine vasopressin-neurophysin II (AVP-NPII) gene. These mutation... | ['Amino Acids', 'Child', 'Child, Preschool', 'Cysteine', 'DNA Restriction Enzymes', 'Diabetes Insipidus, Neurogenic', 'Disulfides', 'Exons', 'Family Health', 'Female', 'Genes, Dominant', 'Glycine', 'Humans', 'Hypothalamus', 'Infant', 'Infant, Newborn', 'Magnetic Resonance Imaging', 'Male', 'Models, Genetic', 'Mutation'... | 11,161,827 | [['D12.125'], ['M01.060.406'], ['M01.060.406.448'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['C12.777.419.135.750', 'C13.351.968.419.135.750', 'C19.700.159.750'], ['D01.248.497.158.874.390', 'D01.875... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pathways of youth gambling problem severity. | Prospective studies are needed to advance knowledge of the developmental features of gambling involvement and associated problems. Developmental pathways of youth gambling problem severity (no problem gambling, at-risk gambling, and problem gambling) are described on the basis of a 3-wave data set that spans midadolesc... | ['Adolescent', 'Adult', 'Behavior, Addictive', 'Female', 'Gambling', 'Humans', 'Male', 'Minnesota', 'Risk Factors'] | 15,783,285 | [['M01.060.057'], ['M01.060.116'], ['F01.145.527.100.120'], ['F01.145.722.408', 'F03.250.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.510', 'Z01.107.567.875.510.510'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.8... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Teleaudiometry as a screening method in school children. | OBJECTIVE: To compare the efficacy and feasibility of teleaudiometry with that of sweep audiometry in elementary school children, using pure-tone audiometry as the gold standard.METHODS: A total of 243 students with a mean age of 8.3 years participated in the study. Of these, 118 were boys, and 125 were girls. The foll... | ['Adolescent', 'Audiometry', 'Audiometry, Pure-Tone', 'Auditory Threshold', 'Child', 'Feasibility Studies', 'Female', 'Hearing Loss', 'Humans', 'Male', 'Mass Screening', 'Reference Values', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Software', 'Telemedicine'] | 26,017,796 | [['M01.060.057'], ['E01.370.382.375.060'], ['E01.370.382.375.060.055'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['M01.060.406'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['C09.218.458.341', 'C10.597.751.418.341', 'C23.888.592.763.393.341'], ['B01.050.1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Radioiodine associated de novo Graves' opthalmopathy in an Asian cohort. | Radioactive iodine in the treatment of Graves' disease has been associated with the development of de novo Graves' ophthalmopathy (GO). In this report, we describe five individuals who required extensive ophthalmic treatment for post-RAI de novo GO. | ['Adult', 'Diagnosis, Differential', 'Female', 'Graves Disease', 'Graves Ophthalmopathy', 'Humans', 'Iodine Radioisotopes', 'Male', 'Middle Aged', 'Radiation Injuries', 'Radiopharmaceuticals', 'Singapore', 'Young Adult'] | 29,177,260 | [['M01.060.116'], ['E01.171'], ['C11.675.349.500', 'C19.874.283.605', 'C19.874.397.370', 'C20.111.555'], ['C11.270.240', 'C11.675.349.500.500', 'C16.320.347', 'C19.874.283.605.500', 'C19.874.397.370.500', 'C20.111.555.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400.500.496', 'D01.496.448.496',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Apparent heterogeneity between leukemic lymphocyte cell lines. | 31P-NMR and polarographic techniques were used to investigate glycolytic versus aerobic oxidative activity in normal and leukemic lymphocytes, and to investigate possible heterogeneity in these parameters between two leukemic cell lines. Molt 3 cells showed a 10-fold higher rate of glutamine-dependent respiration than ... | ['Biological Transport, Active', 'Glutamine', 'Glycolysis', 'Humans', 'Hydrogen-Ion Concentration', 'Kinetics', 'Leukemia', 'Lymphocytes', 'Magnetic Resonance Spectroscopy', 'Oxidation-Reduction', 'Oxygen Consumption', 'Polarography', 'Tumor Cells, Cultured'] | 1,288,099 | [['G03.143.310'], ['D12.125.068.330', 'D12.125.095.461', 'D12.125.154.424'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['C04.557.337'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.55... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G. | APOBEC3G (A3G), a host protein that inhibits HIV-1 reverse transcription and replication in the absence of Vif, displays cytidine deaminase and single-stranded (ss) nucleic acid binding activities. HIV-1 nucleocapsid protein (NC) also binds nucleic acids and has a unique property, nucleic acid chaperone activity, which... | ['APOBEC-3G Deaminase', 'Base Sequence', 'Cytidine Deaminase', 'DNA, Single-Stranded', 'DNA, Viral', 'Fluorescence Polarization', 'HIV Reverse Transcriptase', 'HIV-1', 'Humans', 'Molecular Sequence Data', 'Optical Tweezers', 'RNA', 'Reverse Transcription', 'gag Gene Products, Human Immunodeficiency Virus'] | 17,942,420 | [['D08.811.277.151.486.250.500.750'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.151.486.250'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['D13.444.308.568'], ['E05.196.712.516.600.390'], ['D08.811.913.696.445.308.300.750.187', 'D12.776.964.775.375.545.875', 'D12.7... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Comparison of audio vs. audio + video for the rating of shared decision making in oncology using the observer OPTION5 | BACKGROUND: How non-verbal data may influence observer-administered ratings of shared decision making is unknown. Our objective for this exploratory analysis was to determine the effect of mode of data collection (audio+video vs. audio only) on the scoring of the OPTION5 instrument, an observer rated measure of shared ... | ['Communication', 'Decision Making', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Patient Participation', 'Physician-Patient Relations', 'Tape Recording', 'Video Recording'] | 29,973,207 | [['F01.145.209', 'L01.143'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['F01.100.150.750.500.620', 'F01.145.488.887.500.620', 'N02.421.143.212.300', 'N03.540.245.360.300', 'N05.300.150.800.500.620'], ['F01.829.401.650.675', 'N05.300.660.625'], ['J01.897.280.500.... | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons. | The influence of neurotrophins on GABAergic properties of developing striatal neurons was investigated both in vivo and in vitro. Brain-derived neurotrophic factor (BDNF) specifically elevated cellular GABA content in striatal culture without altering neuronal survival. Neurotrophin-5 produced a similar effect on GABA,... | ['Animals', 'Animals, Newborn', 'Brain-Derived Neurotrophic Factor', 'Cell Differentiation', 'Cells, Cultured', 'Cerebral Cortex', 'Corpus Striatum', 'Glutamate Decarboxylase', 'Nerve Growth Factors', 'Nerve Tissue Proteins', 'Neurons', 'Rats', 'Rats, Sprague-Dawley', 'gamma-Aminobutyric Acid'] | 8,088,442 | [['B01.050'], ['B01.050.050.282'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['G04.152'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['A08.186.211.200.885.287.249.487'], ['D08.811.520.224.125.250'], ['D12.644.276.860', 'D12.776.467.860', 'D12.776.631.600', 'D23.529.850... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
IL-8 and IP-10 expression from human bronchial epithelial cells BEAS-2B are promoted by Streptococcus pneumoniae endopeptidase O (PepO). | BACKGROUND: The bronchial epithelium serves as the first defendant line of host against respiratory inhaled pathogens, mainly through releasing chemokines (e.g. interleukin-8 (IL-8), interferon-induced protein 10 (IP-10) etc.) responsible for neutrophil or lymphocyte recruitment to promote the clearance of inhaled path... | ['Bacterial Proteins', 'Bronchi', 'Cell Line', 'Chemokine CXCL10', 'Cytokines', 'Epithelial Cells', 'Gene Expression Regulation, Enzymologic', 'Humans', 'Interleukin-8', 'Metalloendopeptidases', 'Mitogen-Activated Protein Kinase Kinases', 'NF-KappaB Inhibitor alpha', 'Phosphatidylinositol 3-Kinases', 'Phosphorylation',... | 28,836,948 | [['D12.776.097'], ['A04.411.125'], ['A11.251.210'], ['D12.644.276.374.200.120.500', 'D12.776.467.374.200.120.500', 'D23.125.300.120.500', 'D23.469.200.120.500', 'D23.529.374.200.120.500'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A11.436'], ['G05.308.320'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Construction and expression of DNA vaccine pIRES-Sj97-Sj14-Sj26 and its immunogenicity in mice. | To find a new preventive strategy for the infection of Schistosoma japonica, plasmid pIRES-Sj97-Sj14-Sj26 that contains fatty binding protein (Sj14), GST (Sj26) and paramyocin (Sj97) that are expressed on the membrane, was constructed. RT-PCR was used to detect the expression of Sj14 mRNA, Sj26 mRNA and Sj97 mRNA in th... | ['Animals', 'Antigens, Helminth', 'HeLa Cells', 'Helminth Proteins', 'Humans', 'Immunization', 'Mice', 'Mice, Inbred BALB C', 'RNA, Messenger', 'Schistosoma japonicum', 'Schistosomiasis japonica', 'Vaccines, DNA'] | 18,231,727 | [['B01.050'], ['D23.050.223'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['D12.776.419'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.680.310'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Status of Oral Health Training in U.S. Primary Care Programs: A Qualitative Study to Define Characteristics and Outcomes. | With increasing recognition of the important relationship between oral and systemic health, non-dental health professions schools and programs are now teaching their students about oral health in various ways. This study built on surveys of medical schools, primary care residency and fellowship programs, and other heal... | ['Adult', 'Curriculum', 'Dental Hygienists', 'Education, Dental', 'Health Occupations', 'Humans', 'Internship and Residency', 'Middle Aged', 'Oral Health', 'Primary Health Care', 'Program Development', 'Program Evaluation', 'Qualitative Research', 'Schools, Dental', 'Schools, Medical', 'Surveys and Questionnaires', 'Un... | 31,371,427 | [['M01.060.116'], ['I02.158'], ['M01.526.485.067.105.376', 'N02.360.067.105.376'], ['I02.358.274'], ['H02'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['M01.060.116.630'], ['N01.400.535'], ['N04.590.233.727'], ['N04.452.760'], ['E05.337.820', 'N04.761.685', 'N05.71... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Analysis of chemokines and receptors expression profile in the myelin mutant taiep rat. | Taiep rat has a failure in myelination and remyelination processes leading to a state of hypomyelination throughout its life. Chemokines, which are known to play a role in inflammation, are also involved in the remyelination process. We aimed to demonstrate that remyelination-stimulating factors are altered in the brai... | ['Animals', 'Chemokines', 'Down-Regulation', 'Enzyme-Linked Immunosorbent Assay', 'Microscopy, Fluorescence', 'Myelin Sheath', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Rats, Transgenic', 'Receptors, Chemokine', 'Transcriptome', 'Up-Regulation'] | 25,883,747 | [['B01.050'], ['D12.644.276.374.200', 'D12.776.467.374.200', 'D23.125.300', 'D23.469.200', 'D23.529.374.200'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['E01.370.350.515.458', 'E05.595.458'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acetabular labral tears with underlying chondromalacia: a possible association with high-level running. | PURPOSE: The use of hip arthroscopy has helped delineate intra-articular pathology and has enabled clinicians to further elucidate the factors responsible for injuries, such as running. The subtle development of degenerative changes may be a result of repetitive impact loading associated with this sport. This study pre... | ['Acetabulum', 'Adult', 'Arthroscopy', 'Athletic Injuries', 'Cartilage Diseases', 'Female', 'Hip Injuries', 'Humans', 'Ligaments, Articular', 'Male', 'Middle Aged', 'Running'] | 15,891,725 | [['A02.835.232.043.825.108'], ['M01.060.116'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['C26.115'], ['C05.182', 'C17.300.182'], ['C26.531'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.513.514', 'A02.835.583.512', 'A10.165.669.514'], ['M01.060.116.630'], ['G11.427.410.568.610', 'G11.427.41... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Predicting Progression in Parkinson's Disease Using Baseline and 1-Year Change Measures. | BACKGROUND: Improved prediction of Parkinson's disease (PD) progression is needed to support clinical decision-making and to accelerate research trials.OBJECTIVES: To examine whether baseline measures and their 1-year change predict longer-term progression in early PD.METHODS: Parkinson's Progression Markers Initiative... | ['Aged', 'Biomarkers', 'Brain', 'Disease Progression', 'Dopamine Plasma Membrane Transport Proteins', 'Female', 'Humans', 'Male', 'Middle Aged', 'Parkinson Disease', 'Prospective Studies', 'Severity of Illness Index'] | 31,450,510 | [['M01.060.116.100'], ['D23.101'], ['A08.186.211'], ['C23.550.291.656'], ['D12.776.157.530.450.625.124', 'D12.776.157.530.562.374.500.500', 'D12.776.157.530.937.500', 'D12.776.543.585.450.625.124', 'D12.776.543.585.562.374.500.500', 'D12.776.543.585.937.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
New objective measurement to characterize the porosity of textile implants. | The inflammatory and fibrotic intensity of a foreign body reaction largely depends on the porosity of the implanted material. Furthermore, the size of the pore and its geometry define the capability to allow tissue ingrowth. We present an image analysis system, which allows objectifying in two dimensions the pores' str... | ['Algorithms', 'Image Processing, Computer-Assisted', 'Materials Testing', 'Porosity', 'Prostheses and Implants', 'Reference Standards', 'Software', 'Textiles', 'Tissue Scaffolds'] | 17,497,684 | [['G17.035', 'L01.224.050'], ['L01.224.308'], ['E05.570'], ['G01.374.710'], ['E07.695'], ['E05.978.808'], ['L01.224.900'], ['J01.637.836'], ['E07.206.627', 'E07.695.825']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Redesign of the coenzyme specificity of a dehydrogenase by protein engineering. | Directed mutagenesis and molecular modelling have been used to identify a set of amino-acid side chains in glutathione reductase that confer specificity for the coenzyme NADP+. Systematic replacement of these amino acids, all of which occur in a 'fingerprint' structural motif in the NADP+-binding domain, leaves the sub... | ['Amino Acid Sequence', 'Binding Sites', 'Computer Graphics', 'DNA Mutational Analysis', 'Glutathione Reductase', 'Humans', 'Models, Molecular', 'Molecular Sequence Data', 'NAD', 'NADP', 'Protein Engineering', 'Structure-Activity Relationship', 'Substrate Specificity'] | 2,296,288 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.120'], ['L01.224.108', 'L01.296.110'], ['E05.393.760.700.300'], ['D08.811.682.667.092'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['L01.453.245.667'], ['D03.633.100.759.646.138.694', 'D08.211.589', 'D13.695.667.138.694', 'D13.695.827.06... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence. | Sialic acids are important cell-surface molecules of animals in the deuterostome lineage. Although humans do not express easily detectable amounts of N-glycolylneuraminic acid (Neu5Gc, a hydroxylated form of the common sialic acid N-acetylneuraminic acid, Neu5Ac), it is a major component in great ape tissues, except in... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cloning, Molecular', 'DNA Primers', 'DNA, Complementary', 'Evolution, Molecular', 'Hominidae', 'Humans', 'In Situ Hybridization, Fluorescence', 'Mice', 'Mixed Function Oxygenases', 'Molecular Sequence Data', 'Mutation', 'Pan troglodytes', 'Sequence Homology, Amino Ac... | 9,751,737 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.045.250', 'G16.075.250'], ['B01.050.150.9... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Experimental study on laryngeal cartilage defects repair with differently preserved allogeneic cartilages transplantation]. | OBJECTIVE: To study the effect of laryngeal cartilage defect repair with differently preserved allogeneic cartilage grafts.METHODS: 16 New Zealand white rabbits were used and divided into two groups. A 6 mm x 3 mm x 1 mm whole thickness cartilage defect was made in each side of the thyroid cartilage of each rabbit. In ... | ['Animals', 'Female', 'Male', 'Rabbits', 'Thyroid Cartilage', 'Tissue Preservation', 'Transplantation, Homologous'] | 12,768,720 | [['B01.050'], ['B01.050.150.900.649.313.968.700'], ['A02.165.257.625.870', 'A02.165.407.500.870', 'A04.329.591.870'], ['E01.370.225.500.620.760', 'E01.370.225.750.600.760', 'E02.792.833', 'E05.200.500.620.760', 'E05.200.750.600.760', 'E05.760.833'], ['E04.936.864']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Growth, viability, adhesion potential, and fibronectin expression in fibroblasts cultured on zirconia or feldspatic ceramics in vitro. | Zirconia, a biomaterial widely used in dentistry, has recently attracted much attention for its mechanical strength and toughness. Previously, its lack of mutagenic and carcinogenic power was reported. We describe here other essential aspects to be taken into account to define in vitro the biocompatibility of a materia... | ['Aluminum Silicates', 'Animals', 'Apoptosis', 'Cell Adhesion', 'Cell Line', 'Cell Proliferation', 'Cell Survival', 'Cells, Cultured', 'Ceramics', 'Fibroblasts', 'Fibronectins', 'Fluorescent Antibody Technique', 'Polystyrenes', 'Potassium Compounds', 'Rats', 'Zirconium'] | 18,067,158 | [['D01.056.050.075', 'D01.578.725.025', 'D01.650.550.050.075', 'D01.837.725.700.760.050'], ['B01.050'], ['G04.146.954.035'], ['G04.022'], ['A11.251.210'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['A11.251'], ['J01.637.153'], ['A11.329.228'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Is induction response negatively correlated with constitutive resistance in black mustard? | Black mustard, Brassica nigra, is highly variable in both constitutive resistance and induction response following damage by herbivores. A focal population from Ithaca, New York, was used to test the following two predictions of optimal defense theory: (1) that allocation to resistance will reduce plant performance in ... | ['Animals', 'Butterflies', 'Glucosinolates', 'Indoles', 'Mustard Plant', 'New York', 'Phenotype', 'Plant Leaves', 'Random Allocation'] | 12,487,350 | [['B01.050'], ['B01.050.500.131.617.720.500.500.937.200'], ['D02.886.740.703.350', 'D09.408.348.820.350', 'D09.408.903.703.350'], ['D03.633.100.473'], ['B01.650.940.800.575.912.250.157.200.500'], ['Z01.107.567.875.075.437', 'Z01.107.567.875.350.530', 'Z01.107.567.875.500.530'], ['G05.695'], ['A18.024.812'], ['E05.318.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Role socialization of graduating student nurses: impact of a nursing practicum on professional role conception. | This study examined graduating student nurse role conception changes that occurred during a concentrated clinical preceptorial. A Nursing Role Conceptions Questionnaire was administered to nursing students before (n = 44) and immediately after (n = 41) a 4-week Nursing Practicum; to the students' staff nurse clinical t... | ['Education, Nursing', 'Faculty, Nursing', 'Humans', 'Indiana', 'Nursing Education Research', 'Professional Practice', 'Role', 'Socialization', 'Students, Nursing', 'Surveys and Questionnaires'] | 7,822,623 | [['I02.358.462'], ['M01.526.485.390', 'M01.526.702.250.473', 'N02.360.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.360', 'Z01.107.567.875.510.360'], ['H01.770.644.145.390.413', 'H02.478.395.413', 'I02.358.462.612', 'N04.590.233.508.613.413'], ['N04.452.758'], ['F01.829.316.616'], ['I01.... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Linoleate metabolism in multiple sclerosis. | (1) The levels of oleate and linoleate in the serum have been measured in 14 patients with multiple sclerosis (MS) and in 14 healthy subjects before, during and after a five day period when the normal diet was supplemented with linoleate. (2) In confirmation of earlier work the mean percentage of linoleate in the serum... | ['Adult', 'Chromatography, Gas', 'Diet', 'Female', 'Humans', 'Intestinal Absorption', 'Linoleic Acids', 'Lipids', 'Male', 'Middle Aged', 'Multiple Sclerosis', 'Oleic Acids', 'Plants, Edible', 'Seeds'] | 5,551,691 | [['M01.060.116'], ['E05.196.181.349'], ['G07.203.650.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', 'G10.261.353.500'], ['D10.251.355.310.515', 'D10.251.355.343.500'], ['D10'], ['M01.060.116.630'], ['C10.11... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Gene expression analysis of Gata3-/- mice by using cDNA microarray technology. | Transcription factor Gata3 is implicated in the formation of autosomal dominant hypoparathyroidism, sensorineural deafness, and renal anomaly (HDR) syndrome. We pursued to identify the potential Gata3 target genes by profiling the gene expression pattern in E9.5 Gata3-/- mouse embryos. Altogether four independent micro... | ['Adaptor Proteins, Signal Transducing', 'Adaptor Proteins, Vesicular Transport', 'Animals', 'Apoptosis Regulatory Proteins', 'Branchial Region', 'DNA-Binding Proteins', 'GATA3 Transcription Factor', 'Gene Expression Profiling', 'Gene Expression Regulation, Developmental', 'Hearing Loss, Sensorineural', 'Hypoparathyroi... | 15,769,480 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['D12.776.543.990.150'], ['B01.050'], ['D12.644.360.075', 'D12.776.476.075'], ['A16.142'], ['D12.776.260'], ['D12.776.260.235.687', 'D12.776.260.257.300', 'D12.776.930.216.687', 'D12.776.930.314.300'], ['E05.393.332'], ['G05.308.310'], ['C09.218.458.341.887', ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The relationship of median nerve F-wave parameters with severity and subtypes of carpal tunnel syndrome. | PURPOSE: F-wave analysis may help affirm or disprove a compression neuropathy. In this study we have analysed the effects of focal median nerve injury on F wave in Carpal Tunnel Syndrome (CTS).METHOD: We studied 57 patients (100 hands) with clinical and electrophysiological CTS and 31 (62 hands) healthy subjects. Media... | ['Adult', 'Carpal Tunnel Syndrome', 'Electrodiagnosis', 'Female', 'Humans', 'Male', 'Median Nerve', 'Middle Aged', 'Neural Conduction', 'Severity of Illness Index'] | 23,948,836 | [['M01.060.116'], ['C10.668.829.500.500.200', 'C10.668.829.550.200', 'C26.844.150.206'], ['E01.370.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.800.800.720.050.500'], ['M01.060.116.630'], ['G07.265.753', 'G11.561.601'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Geotrichum candidum P-5 produces an intracellular serine protease resembling chymotrypsin. | A wide range of intra- and extracellular microbial proteases has been studied and characterized. These enzymes are mostly extracellular and in some cases they may resemble 'classical' serine proteases. As part of a programme in which the lipase and protease activities of the fungus Geotrichum candidum are being studied... | ['Chymotrypsin', 'Geotrichum', 'Kinetics', 'Serine Endopeptidases'] | 8,930,136 | [['D08.811.277.656.300.760.176', 'D08.811.277.656.959.350.176'], ['B01.300.381.380'], ['G01.374.661', 'G02.111.490'], ['D08.811.277.656.300.760', 'D08.811.277.656.959.350']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment of Pneumocystis carinii pneumonia. | Mild to moderately severe Pneumocystis carinii pneumonia in patients with AIDS was treated in a clinical trial with a combination regimen of primaquine and clindamycin, and the efficacy of this regimen was compared with that of the conventional treatment regimen of trimethoprim/sulfamethoxazole. The results revealed th... | ['Acquired Immunodeficiency Syndrome', 'Adult', 'Clindamycin', 'Drug Therapy, Combination', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pneumonia, Pneumocystis', 'Primaquine', 'Trimethoprim, Sulfamethoxazole Drug Combination'] | 2,060,533 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.116'], ['D03.383.773.532.500.125', 'D09.408.471.500.125'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Serum creatine kinase is an unreliable predictor of ectopic pregnancy. | OBJECTIVE: To compare serum creatine kinase (CK) values in patients with ectopic pregnancy vs patients with threatened miscarriage or normal pregnancy.METHODS: An observational case-control study was performed at an urban teaching hospital. Pregnant women with a quantitative beta-hCG obtained for suspicion of ectopic p... | ['Abortion, Threatened', 'Adolescent', 'Adult', 'Analysis of Variance', 'Biomarkers', 'Case-Control Studies', 'Chorionic Gonadotropin, beta Subunit, Human', 'Creatine Kinase', 'Female', 'Humans', 'Pregnancy', 'Pregnancy, Ectopic', 'Reference Values'] | 9,562,191 | [['C13.703.090'], ['M01.060.057'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D23.101'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D06.472.699.322.326.125', 'D06.472.699.649.367.125', 'D12.644.548.726.367.125', 'D12.776.780.400.125', 'D23... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Compensatory spinopelvic balance over the hip axis and better reliability in measuring lordosis to the pelvic radius on standing lateral radiographs of adult volunteers and patients. | STUDY DESIGN: Sagittal alignments, including lumbar lordosis and spinopelvic balance (measured from C7, S1, and hip axis reference points for the relative positions of the spine and sacropelvis over the hips), were studied on standing 36-in. lateral radiographs of adult volunteers (control subjects) and patients who ha... | ['Adult', 'Biomechanical Phenomena', 'Female', 'Hip Joint', 'Humans', 'Intervertebral Disc Displacement', 'Lordosis', 'Lumbar Vertebrae', 'Male', 'Middle Aged', 'Pelvic Bones', 'Postural Balance', 'Radiography', 'Reference Values', 'Reproducibility of Results', 'Sacrum', 'Scoliosis', 'Spinal Diseases', 'Spondylolisthes... | 9,728,376 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.900.307', 'C23.300.707.952'], ['C05.116.900.800.750'], ['A02.835.232.834.519'], ['M01.060.116.630'], ['A02.835.232.043.825'], ['F02.830.816.541.752', 'G07.888.750.500', 'G11.427.690', 'G11.5... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Experiences with Sinemet CR in the Paracelsus-Elena-Klinik. | In an open-label study, 20 patients with peak-dose dyskinesia and/or end-of-dose fluctuations were switched from standard Sinemet to Sinemet CR. Seventeen patients showed good tolerance and therapeutic results for at least 6 months. However, 10 patients showed a slight decrease of this improvement after 6 months; 3 had... | ['Adult', 'Aged', 'Antiparkinson Agents', 'Carbidopa', 'Delayed-Action Preparations', 'Drug Combinations', 'Humans', 'Levodopa', 'Middle Aged', 'Parkinson Disease'] | 2,586,768 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.427.090.050'], ['D02.092.311.200.538.200', 'D02.442.200', 'D02.455.426.559.389.657.166.175.200.538.200'], ['D26.255.210', 'E02.319.300.253'], ['D26.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.092.311.200.480', 'D02.455.426.559.389.657.166.175.200.48... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Predicting effects of structural stress in a genome-reduced model bacterial metabolism. | Mycoplasma pneumoniae is a human pathogen recently proposed as a genome-reduced model for bacterial systems biology. Here, we study the response of its metabolic network to different forms of structural stress, including removal of individual and pairs of reactions and knockout of genes and clusters of co-expressed gen... | ['Gene Expression Regulation, Bacterial', 'Gene Knockdown Techniques', 'Genome, Bacterial', 'Humans', 'Metabolic Networks and Pathways', 'Models, Biological', 'Mutation', 'Pneumonia, Mycoplasma', 'Stress, Physiological'] | 22,934,134 | [['G05.308.300'], ['E05.393.335.500'], ['G05.360.340.358.207'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.493'], ['E05.599.395'], ['G05.365.590'], ['C01.150.252.400.610.610.760', 'C01.150.252.620.500', 'C01.748.610.540.545', 'C08.381.677.540.500', 'C08.730.610.540.545'], ['G07.775']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biological monitoring of persons exposed to methanol vapours. | Five volunteers were exposed to constant and suitably graded concentrations of methanol vapours for a period of 8 h. The retention of methanol in the lungs and the course of its excretion in urine were monitored at single and at daily repeated exposures. From the concentration in inspired air, lung retention, minute lu... | ['Adult', 'Air Pollutants, Occupational', 'Breath Tests', 'Humans', 'Male', 'Methanol', 'Middle Aged', 'Physical Exertion'] | 7,251,180 | [['M01.060.116'], ['D27.888.284.101.268'], ['E01.370.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.623'], ['M01.060.116.630'], ['G11.427.683']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of caffeine and adenosine on G2 repair: mitotic delay and chromosome damage. | Proliferating plant cells treated during the late S period with 5-aminouracil (AU), give the typical response that DNA-damaging agents induce, characterized by: an important mitotic delay, and a potentiation of the chromosome damage by caffeine post-treatment. The study of labelled prophases, after a tritiated thymidin... | ['Adenosine', 'Caffeine', 'Chromosomes', 'DNA Repair', 'Interphase', 'Mitosis', 'Plants', 'Uracil'] | 3,982,446 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['G02.111.222', 'G05.219'], ['G04.144.500'], ['G04.144.220.220.781', 'G05.113.220.781'], ['B01.650'], ['D03.383.742.698.875']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MicroRNA-1271 suppresses the proliferation and invasion of colorectal cancer cells by regulating metadherin/Wnt signaling. | Recent studies have reported an important role for microRNA-1271 (miR-1271) in tumorigenesis. However, the role of miR-1271 in colorectal cancer remains unknown. Here, we found that miR-1271 was significantly decreased in colorectal cancer tissues and cell lines. Overexpression of miR-1271 inhibited cell proliferation,... | ["3' Untranslated Regions", 'Cell Adhesion Molecules', 'Cell Line', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Colon', 'Colorectal Neoplasms', 'Gene Expression Regulation, Neoplastic', 'Genes, Reporter', 'Humans', 'Intestinal Mucosa', 'Membrane Proteins', 'MicroRNAs', 'Mutation', 'Neoplasm Proteins', '... | 29,315,995 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The structure of AhrC, the arginine repressor/activator protein from Bacillus subtilis. | In the Gram-positive bacterium Bacillus subtilis the concentration of the amino acid L-arginine is controlled by the transcriptional regulator AhrC. The hexameric AhrC protein binds in an L-arginine-dependent manner to pseudo-palindromic operators within the promoter regions of arginine biosynthetic and catabolic gene ... | ['Amino Acid Sequence', 'Bacillus subtilis', 'Bacterial Proteins', 'Biopolymers', 'Crystallization', 'Crystallography, X-Ray', 'Models, Molecular', 'Molecular Sequence Data', 'Protein Conformation', 'Repressor Proteins', 'Sequence Homology, Amino Acid', 'Trans-Activators'] | 11,856,827 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D12.776.097'], ['D05.750.078', 'D25.720.099', 'J01.637.051.720.099'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Interhemispheric transfer of olfactory information in homing pigeon. | The role of the anterior commissure in discrimination of and habituation to olfactory stimuli was studied in pigeons by measuring changes in the heart rate. In order to exclude any trigeminal response, we presented odorous stimuli to groups of pigeons with one olfactory nerve cut and either the ipsilateral or the contr... | ['Animals', 'Central Nervous System', 'Columbidae', 'Functional Laterality', 'Heart', 'Heart Rate', 'Olfactory Nerve', 'Olfactory Pathways', 'Pentanols', 'Time Factors'] | 3,358,853 | [['B01.050'], ['A08.186'], ['B01.050.150.900.248.165.150'], ['F02.830.297.425', 'G11.561.225.425'], ['A07.541'], ['E01.370.600.875.500', 'G09.330.380.500'], ['A08.800.800.120.640'], ['A08.186.211.180.699', 'A08.612.220.640'], ['D02.033.415.640', 'D10.289.640'], ['G01.910.857']] | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A microcomputer system in the delivery suite. | Microcomputer systems have been installed in the delivery suites of two obstetric units which cater between them for nearly 10 000 deliveries annually. The midwifery and medical staff enter administrative, antenatal, anaesthetic and delivery details during labour and as soon after delivery as possible. The computer pri... | ['Adult', 'Computers', 'Data Collection', 'Delivery, Obstetric', 'England', 'Female', 'Hospital Departments', 'Humans', 'Infant, Newborn', 'Microcomputers', 'Obstetrics and Gynecology Department, Hospital', 'Pregnancy', 'Software'] | 6,547,349 | [['M01.060.116'], ['L01.224.230.260'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['E04.520.252'], ['Z01.542.363.300'], ['N02.278.216.500.968', 'N04.452.442.452.422'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['L01.224.230.260.550'], ['N02.278.216.500.968.495', 'N... | ['Named Groups [M]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Being open with patients and learning how to apologize. | This article outlines the National Patient Safety Agency's 'Being Open' policy and argues that it has the potential to create a much more patient-centred NHS. However, it is very easy to say the word 'sorry', but much harder to say the word effectively and in a meaningful way. The NHS should not underestimate the task ... | ['Codes of Ethics', 'Communication', 'Humans', 'Liability, Legal', 'Medical Errors', 'Nurse-Patient Relations', 'Organizational Policy', 'State Medicine', 'Truth Disclosure', 'United Kingdom'] | 20,220,650 | [['K01.752.566.479.068', 'K01.752.566.479.171.066', 'N04.761.700.350.324', 'N05.350.213', 'N05.350.340.080', 'N05.700.350.324'], ['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.583.490', 'N03.706.535.547'], ['N02.421.450'], ['F01.829.401.650.600', 'N05.300.660.560'], ['I01.655... | ['Humanities [K]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Using Relational Agents to Promote Family Communication Around Type 1 Diabetes Self-Management in the Diabetes Family Teamwork Online Intervention: Longitudinal Pilot Study. | BACKGROUND: Family conflict can reduce adolescent adherence to type 1 diabetes management tasks. The Family Teamwork in-person intervention was shown to be efficacious in reducing conflict and low adherence to diabetes-related tasks. Its reach and potential impact, however, were limited by the need to deliver the inter... | ['Adolescent', 'Child', 'Communication', 'Diabetes Mellitus, Type 1', 'Female', 'Humans', 'Internet-Based Intervention', 'Longitudinal Studies', 'Male', 'Pilot Projects', 'Self-Management'] | 31,538,940 | [['M01.060.057'], ['M01.060.406'], ['F01.145.209', 'L01.143'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500.688'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['E05.318.372.750', 'E05.337.737'... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Forward propulsion asymmetry is indicative of changes in plantarflexor coordination during walking in individuals with post-stroke hemiparesis. | BACKGROUND: A common measure of rehabilitation effectiveness post-stroke is self-selected walking speed, yet individuals may achieve the same speed using different coordination strategies. Asymmetry in the propulsion generated by each leg can provide insight into paretic leg coordination due to its relatively strong co... | ['Aged', 'Ankle Joint', 'Biomechanical Phenomena', 'Computer Simulation', 'Female', 'Gait', 'Humans', 'Leg', 'Male', 'Middle Aged', 'Muscle, Skeletal', 'Musculoskeletal Physiological Phenomena', 'Paresis', 'Rehabilitation', 'Stroke Rehabilitation', 'Walking'] | 24,973,825 | [['M01.060.116.100'], ['A02.835.583.378.062'], ['G01.154.090', 'G01.374.089'], ['L01.224.160'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['M01.060.116.630'], ['A02.633.567', 'A10.690.552.500'], ['G11.427'], ['C10.597.636', 'C23.888.592.643'], ... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Aberration correction with soft contact lens: is the postlens tear film important? | PURPOSE: A number of factors may influence the performance of soft contact lenses designed to correct the aberrations of the eye. Although the effect of many of these factors has been investigated, the effect of postlens tear film has not. We estimated the optical effect of the postlens tear film by using simplified mo... | ['Computer Simulation', 'Contact Lenses, Hydrophilic', 'Humans', 'Models, Biological', 'Refractive Errors', 'Tears'] | 12,772,762 | [['L01.224.160'], ['E07.632.500.276.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['C11.744'], ['A12.200.882']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Exogenously administered prostaglandins modulate pulmonary granulomas induced by Schistosoma mansoni eggs. | The inflammatory modulating activity of specific prostaglandins has been examined for both immune and foreign-body types of pulmonary granulomas. Lung granuloma formation generated in mice by embolization of Schistosoma mansoni eggs was markedly suppressed by treatment with the stable, functional analog of prostaglandi... | ['Animals', 'Antibodies', 'B-Lymphocytes', 'Cyclophosphamide', 'Female', 'Granuloma', 'Lung Diseases', 'Mice', 'Mice, Inbred CBA', 'Ovum', 'Prostaglandins', 'Schistosoma mansoni', 'Schistosomiasis', 'Spleen', 'T-Lymphocytes', 'T-Lymphocytes, Regulatory'] | 6,220,612 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['C15.604.515.292', 'C23.550.382'], ['C08.381'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increasing isoflurane concentration may cause paradoxical increases in the EEG bispectral index in surgical patients. | We have studied the effects of increases in isoflurane concentration on the EEG bispectral index (BIS) in 70 patients anaesthetized with isoflurane-nitrous oxide-sufentanil for major abdominal surgery. During surgery, baseline BIS was recorded at 0.8% end-tidal isoflurane with nitrous oxide in oxygen (FIO2 0.35). After... | ['Abdomen', 'Adolescent', 'Adult', 'Aged', 'Anesthetics, Inhalation', 'Dose-Response Relationship, Drug', 'Electroencephalography', 'Female', 'Hemodynamics', 'Humans', 'Isoflurane', 'Male', 'Middle Aged', 'Monitoring, Intraoperative', 'Prospective Studies'] | 10,740,544 | [['A01.923.047'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.376.300', 'E01.370.405.245'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.355.601.570'], ['M01.060.11... | ['Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons. | When capsaicin, the pungent compound in hot pepper, is applied to epithelia it produces pain, allodynia, and hyperalgesia. We investigated, using whole cell path clamp, whether some of these responses induced by capsaicin could be a consequence of capsaicin blocking I(A) currents, a reduction in which, such as occurs i... | ['Alkaloids', 'Animals', 'Benzylamines', 'Calcium-Calmodulin-Dependent Protein Kinase Type 2', 'Calcium-Calmodulin-Dependent Protein Kinases', 'Calmodulin', 'Capsaicin', 'Carbazoles', 'Carcinogens', 'Cyclic AMP', 'Cyclic GMP', 'Cyclic GMP-Dependent Protein Kinases', 'Cytidine Triphosphate', 'Electric Stimulation', 'Enz... | 12,626,618 | [['D03.132'], ['B01.050'], ['D02.092.200', 'D02.455.426.559.389.140.210'], ['D08.811.913.696.620.682.700.125.200', 'D12.644.360.100.200', 'D12.776.476.100.200'], ['D08.811.913.696.620.682.700.125', 'D12.644.360.100', 'D12.776.476.100'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['D02.06... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication. | Replication of arboviruses in their arthropod vectors is controlled by innate immune responses. The RNA sequence-specific break down mechanism, RNA interference (RNAi), has been shown to be an important innate antiviral response in mosquitoes. In addition, immune signaling pathways have been reported to mediate arbovir... | ['Aedes', 'Animals', 'Chikungunya Fever', 'Chikungunya virus', 'Female', 'Host-Pathogen Interactions', 'Immunity, Innate', 'Signal Transduction', 'Virus Replication'] | 25,058,001 | [['B01.050.500.131.617.720.500.500.750.712.500.875.100'], ['B01.050'], ['C01.920.500.078.184', 'C01.925.081.198', 'C01.925.782.930.100.184'], ['B04.820.578.875.054.198'], ['G06.462', 'G16.527.200'], ['G12.450.564'], ['G02.111.820', 'G04.835'], ['G06.920.925']] | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Does ingestion of regular coffee influence serum lipid profile in dialysis patients? | We checked whether dialysis patients who drink coffee might have a serum lipid profile different from that of nondrinkers of coffee. The study was performed in 30 patients (26 on peritoneal dialysis, 4 on hemodialysis). Group I included patients who drank 1 - 3 cups of coffee daily (140 - 420 mg caffeine) for at least ... | ['Anthropometry', 'Body Mass Index', 'Cholesterol, HDL', 'Coffee', 'Female', 'Humans', 'Kidney Failure, Chronic', 'Lipids', 'Lipoproteins, LDL', 'Male', 'Middle Aged', 'Renal Dialysis'] | 19,886,342 | [['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['D20.215.784.249', 'G07.203.100.325', 'J02.200.325'], ['B01.050.150.900... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. | Inflammation is the natural body defense mechanism for the removal of injurious agents, necrosed cells and tissues from the body. This study was aimed to evaluate the anti-inflammatory and platelet aggregation effects of three medicinal plants of Pakistan. Methanolic extract of garden pea inhibited arachidonic acid (AA... | ['Arachidonic Acid', 'Cicer', 'Cyclooxygenase 2', 'Cyclooxygenase 2 Inhibitors', 'Dinoprostone', 'Dose-Response Relationship, Drug', 'Humans', 'Indomethacin', 'Methanol', 'Peas', 'Plant Extracts', 'Platelet Activating Factor', 'Platelet Aggregation', 'Platelet Aggregation Inhibitors', 'Platelet Function Tests', 'Recomb... | 22,876,614 | [['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['B01.650.940.800.575.912.250.401.150'], ['D08.811.600.720.750'], ['D27.505.519.389.310.500', 'D27.505.696.663.850.014.040.500.500.500', 'D27.505.954.158.030.500.500', 'D27.505.954.329.030.500.500'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Quantification of three triterpenic acids in dried rosemary using HPLC-fluorescence detection and 4-(4,5-diphenyl-1H-imidazole-2-yl)benzoyl chloride derivatization. | Functional triterpenic acids such as ursolic acid (UA), oleanolic acid (OA) and betulinic acid (BA) are representative ingredients in rosemary that may have health benefits. UA, OA and BA in rosemary extracts were derivatized with 4-(4,5-diphenyl-1H-imidazole-2-yl)benzoyl chloride (DIB-Cl) and detected using HPLC-fluor... | ['Benzoates', 'Calibration', 'Chromatography, High Pressure Liquid', 'Fluorescence', 'Food Analysis', 'Imidazoles', 'Limit of Detection', 'Oleanolic Acid', 'Pentacyclic Triterpenes', 'Reproducibility of Results', 'Rosmarinus', 'Temperature', 'Triterpenes'] | 30,520,219 | [['D02.241.223.100', 'D02.455.426.559.389.127'], ['E05.978.155'], ['E05.196.181.400.300'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['E05.362', 'J01.576.423.850.100'], ['D03.383.129.308'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['D02.455.849.919.530.733', 'D02.455.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Interaction of Cigarette Smoking History With APOE Genotype and Age on Amyloid Level, Glucose Metabolism, and Neurocognition in Cognitively Normal Elders. | INTRODUCTION: Chronic cigarette smoking is associated with increased risk for Alzheimer's disease (AD). The goal of this study was to determine if smoking history moderated the associations of age and APOE genotype (the most robust risk factors for AD) on brain amyloid deposition, glucose metabolism, and neurocognition... | ['Aged', 'Aged, 80 and over', 'Aging', 'Alzheimer Disease', 'Apolipoprotein E4', 'Brain', 'Cognition', 'Female', 'Genotype', 'Glucose', 'Humans', 'Male', 'Middle Aged', 'Plaque, Amyloid', 'Risk Factors', 'Smoking'] | 25,847,292 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D10.532.091.500.750', 'D12.776.070.400.500.750', 'D12.776.521.120.500.750'], ['A08.186.211'], ['F02.463.188'], ['G05.380'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Improved outcome of extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest--a comparison with that for extracorporeal rescue for in-hospital cardiac arrest. | PURPOSE: The aim was to investigate the effects of extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) and compare the results with those of in-hospital cardiac arrest (IHCA).METHODS: We analyzed our extracorporeal membrane oxygenation (ECMO) results for patients who received E... | ['Cardiopulmonary Resuscitation', 'Extracorporeal Membrane Oxygenation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Out-of-Hospital Cardiac Arrest', 'Prospective Studies', 'Treatment Outcome'] | 24,992,872 | [['E02.365.647.110'], ['E02.880.301', 'E04.292.451'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.383.610'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Roles of nitric oxide synthase isoforms in cutaneous vasodilation induced by local warming of the skin and whole body heat stress in humans. | Nitric oxide (NO) participates in the cutaneous vasodilation caused by increased local skin temperature (Tloc) and whole body heat stress in humans. In forearm skin, endothelial NO synthase (eNOS) participates in vasodilation due to elevated Tloc and neuronal NO synthase (nNOS) participates in vasodilation due to heat ... | ['Adult', 'Body Temperature Regulation', 'Female', 'Heat-Shock Response', 'Humans', 'Male', 'Nitric Oxide Synthase', 'Skin', 'Skin Temperature', 'Vasodilation'] | 19,745,188 | [['M01.060.116'], ['G07.110.232', 'G07.410.421', 'G16.012.500.535'], ['G07.775.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.664.500.772'], ['A17.815'], ['G07.110.753', 'G13.750.844'], ['G09.330.380.928']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Specific cleavage of histidine-containing peptides by copper(II). | Copper(II) cleaves with moderate specificity peptides containing Ser-His or Thr-His sequences, at the N-terminal side of the hydroxyaminoacyl residue. The reaction is slow, and is first-order in peptide: CuII complex, with a half-life of several hours at 62 degrees C in sodium bicarbonate buffer, pH 8. Cleavage of othe... | ['Copper', 'Histidine', 'Hydrogen Bonding', 'Hydrogen-Ion Concentration', 'Proteins'] | 8,897,094 | [['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D12.125.072.329', 'D12.125.142.308'], ['G02.282'], ['G02.300'], ['D12.776']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of cimetidine and probenecid on pilsicainide renal clearance in humans. | OBJECTIVE: To investigate the effect of cimetidine and probenecid on the renal clearance of pilsicainide in healthy subjects.METHODS: Nine healthy men (age range, 21 to 38 years) were given oral doses of 50 mg pilsicainide hydrochloride alone, with coadministration of 800 mg oral cimetidine, or with coadministration of... | ['Adult', 'Anti-Arrhythmia Agents', 'Chromatography, High Pressure Liquid', 'Cimetidine', 'Cross-Over Studies', 'Enzyme Inhibitors', 'Humans', 'Kidney', 'Lidocaine', 'Male', 'Probenecid', 'Reference Values', 'Uricosuric Agents'] | 10,741,624 | [['M01.060.116'], ['D27.505.954.411.097'], ['E05.196.181.400.300'], ['D02.078.370.200', 'D03.383.129.308.130'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['D27.505.519.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['D02.065.199.092.500', 'D02.092.146.113.092.500'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Dual free flap transfer using forearm flap for mandibular reconstruction. | To reconstruct a composite mandibular defect, we have simultaneously transferred a vascularized bone graft or osteocutaneous flap together with a forearm flap. The radial forearm flap, being thin, pliable, and having a long vascular stalk, served as mucosal lining and/or an interpositional flap acting as a vascular bri... | ['Adult', 'Aged', 'Bone Transplantation', 'Female', 'Forearm', 'Humans', 'Male', 'Mandible', 'Middle Aged', 'Mouth Mucosa', 'Mouth Neoplasms', 'Necrosis', 'Osteoradionecrosis', 'Speech Intelligibility', 'Surgical Flaps', 'Treatment Outcome'] | 1,468,916 | [['M01.060.116'], ['M01.060.116.100'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['A01.378.800.585'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['M01.060.116.630'], ['A10.615.550.599', 'A14.549.512'], ['C04.588.443.591', 'C07.465.530'], ['C23.550.7... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Measuring public opinion on alcohol policy: a factor analytic study of a US probability sample. | Public opinion has been one factor affecting change in policies designed to reduce underage alcohol use. Extant research, however, has been criticized for using single survey items of unknown reliability to define adult attitudes on alcohol policy issues. The present investigation addresses a critical gap in the litera... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Alcohol Drinking', 'Attitude to Health', 'Cross-Sectional Studies', 'Female', 'Health Policy', 'Humans', 'Male', 'Middle Aged', 'Public Opinion', 'United States'] | 12,573,680 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['F01.145.317.269'], ['F01.100.150', 'N05.300.150'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Techniques and "tricks": different uses of Foley catheter in cardiovascular surgery]. | The use of Foley catheter is well established for bladder catheterization. The authors have used it, occasionally, in many unconventional ways to cope with difficult situations found at surgery. 1.Catastrophic haemorrhage during redo sternotomy. 2. Non touch technique for graft to aorta proximal anastomosis during CABG... | ['Anastomosis, Surgical', 'Aortic Diseases', 'Calcinosis', 'Cardiac Surgical Procedures', 'Catheterization', 'Heart Ventricles', 'Hemorrhage', 'Humans', 'Pulmonary Artery', 'Reoperation', 'Sternum'] | 15,895,124 | [['E04.035'], ['C14.907.109'], ['C18.452.174.130'], ['E04.100.376', 'E04.928.220'], ['E02.148', 'E05.157'], ['A07.541.560'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.114.715'], ['E04.690'], ['A02.835.232.570.750']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The national landscape of deceased donor kidney transplantation for the highly sensitized: Transplant rates, waitlist mortality, and posttransplant survival under KAS. | Deceased donor kidney transplantation (DDKT) rates for highly sensitized (HS) candidates increased early after implementation of the Kidney Allocation System (KAS) in 2014. However, this may represent a bolus effect, and a granular investigation of the current state of DDKT for HS candidates remains lacking. We studied... | ['Adult', 'Aged', 'Female', 'Humans', 'Kidney Failure, Chronic', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Registries', 'Survival Rate', 'Tissue Donors', 'Waiting Lists'] | 30,372,592 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.060.116.630'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.360.300.715.700', 'N06.850.520.308.970'], ['E05.... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Structural and immunochemical relatedness suggests a conserved pathogenicity motif for secondary cell wall polysaccharides in Bacillus anthracis and infection-associated Bacillus cereus. | Bacillus anthracis (Ba) and human infection-associated Bacillus cereus (Bc) strains Bc G9241 and Bc 03BB87 have secondary cell wall polysaccharides (SCWPs) comprising an aminoglycosyl trisaccharide repeat: ?4)-â-d-ManpNAc-(1?4)-â-d-GlcpNAc-(1?6)-á-d-GlcpNAc-(1?, substituted at GlcNAc residues with both á- and â-Galp. I... | ['Animals', 'Bacillus anthracis', 'Bacillus cereus', 'Nuclear Magnetic Resonance, Biomolecular', 'Polysaccharides', 'Primates', 'Rabbits'] | 28,832,613 | [['B01.050'], ['B03.300.390.400.158.218.151', 'B03.353.500.100.218.151', 'B03.510.100.100.218.151', 'B03.510.415.400.158.218.151', 'B03.510.460.410.158.218.151'], ['B03.300.390.400.158.218.252', 'B03.353.500.100.218.252', 'B03.510.100.100.218.252', 'B03.510.415.400.158.218.252', 'B03.510.460.410.158.218.252'], ['E05.19... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical audit makes progress in care and teamwork. | Clinical audit should be about improving the delivery of care to patients as well as promoting multidisciplinary working in clinical teams. For clinical audit to move forward it must relate to, and be integrated with, four key areas: clinical effectiveness, the contracting process, patient-focused care and the developm... | ['Humans', 'Male', 'Nursing Audit', 'Patient Care Team', 'Patient-Centered Care', 'Quality Assurance, Health Care', 'State Medicine', 'United Kingdom'] | 8,826,366 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.700.250.520', 'N05.700.175.520'], ['N04.590.715'], ['N04.590.233.727.407'], ['N04.761.700', 'N05.700'], ['N03.349.550.902', 'N03.858'], ['Z01.542.363']] | ['Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Embryotoxicity of T-2 toxin and secalonic acid in embryonic chicks varies with the site of administration. | A crucial role of the site of administration in the sensitivity of the alternative system using chick embryo for testing embryotoxicity was demonstrated by morphological evaluation of the effects of T-2 toxin and secalonic acid D, and by incorporation of [14C]sodium acetate radioactivity. Secalonic acid D, administered... | ['Age Factors', 'Animals', 'Chick Embryo', 'Dose-Response Relationship, Drug', 'T-2 Toxin', 'Teratogens', 'Xanthenes', 'Xanthones', 'Yolk Sac'] | 1,440,417 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['A13.350.150', 'A16.331.200'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.455.849.765.850.950.500', 'D04.345.891.950.500', 'D23.946.587.933.950.500'], ['D27.888.569.864'], ['D03.633.300.953'], ['D03.633.300.953.852'], ['A10.615.284.981', 'A16.254.750.981', 'A16.... | ['Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Proteomic investigation of Vibrio alginolyticus challenged Caenorhabditis elegans revealed regulation of cellular homeostasis proteins and their role in supporting innate immune system. | Caenorhabditis elegans has been the preferred model system for many investigators to study pathogenesis. In the present investigation, regulation of C. elegans proteome was explored against V. alginolyticus infection using quantitative proteomics approach. Proteins were separated using 2D-DIGE and the differentially re... | ['Animals', 'Blotting, Western', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Electrophoresis, Gel, Two-Dimensional', 'Host-Pathogen Interactions', 'Immunity, Innate', 'Protein Interaction Maps', 'Proteome', 'Proteomics', 'Vibrio Infections', 'Vibrio alginolyticus'] | 25,044,714 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['E05.196.401.250', 'E05.301.300.230'], ['G06.462', 'G16.527.200'], ['G12.450.564'], ['G03.493.750'], ['D12.776.817'], ['H01.158.201.843', ... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Finding a common motif of RNA sequences using genetic programming: the GeRNAMo system. | We focus on finding a consensus motif of a set of homologous or functionally related RNA molecules. Recent approaches to this problem have been limited to simple motifs, require sequence alignment, and make prior assumptions concerning the data set. We use genetic programming to predict RNA consensus motifs based solel... | ['Algorithms', 'Amino Acid Motifs', 'Animals', 'Base Sequence', 'Computational Biology', 'Evolution, Molecular', 'Ferritins', 'Humans', 'MicroRNAs', 'Models, Genetic', 'Molecular Sequence Data', 'Nucleic Acid Conformation', 'RNA', 'Sequence Alignment', 'Sequence Analysis, RNA'] | 17,975,271 | [['G17.035', 'L01.224.050'], ['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['H01.158.273.180', 'L01.313.124'], ['G05.045.250', 'G16.075.250'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['B01.050.150.900.649.313.988.400.112.4... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Identification of type II and III DDR2 inhibitors. | Discoidin domain-containing receptors (DDRs) exhibit a unique mechanism of action among the receptor tyrosine kinases (RTKs) because their catalytic activity is induced by extracellular collagen binding. Moreover, they are essential components in the assimilation of extracellular signals. Recently, DDRs were reported t... | ['Discoidin Domain Receptors', 'Drug Design', 'Fluorescence', 'High-Throughput Screening Assays', 'Ligands', 'Protein Kinase Inhibitors', 'Protein Structure, Tertiary', 'Receptor Protein-Tyrosine Kinases', 'Receptors, Mitogen', 'Structure-Activity Relationship'] | 24,754,677 | [['D08.811.913.696.620.682.725.400.005', 'D12.776.543.750.630.005', 'D12.776.543.750.685.050', 'D12.776.543.750.705.880.300'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['E05.916.680'], ['D27.720.470.480'], ['D27.505.519.389.755'], ['G02.1... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
High-Resolution Scanning Electron Microscopy and Immuno-Gold Labeling of the Nuclear Lamina and Nuclear Pore Complex. | Scanning electron microscopy (SEM) is a technique used to image surfaces. Field emission SEMs (feSEMs) can resolve structures that are ~0.5-1.5 nm apart. FeSEM, therefore is a useful technique for imaging molecular structures that exist at surfaces such as membranes. The nuclear envelope consists of four membrane surfa... | ['Animals', 'Female', 'Gold', 'Microscopy, Electron, Scanning', 'Nuclear Envelope', 'Nuclear Lamina', 'Nuclear Pore', 'Oocytes', 'Staining and Labeling'] | 27,147,058 | [['B01.050'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['A11.284.149.165.630', 'A11.284.149.450.700', 'A11.284.430.106.279.692', 'A11.284.835.514.700'], ['A11.284.149.165.630.500', 'A11.284.430.106.279.345.700.700', 'A11.284.430.106.279.692.314', 'A11.28... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Decreased fibrinolytic activity in human atherosclerotic vessels. | Using a semi-quantitative, histochemical fibrin slide technique, plasminogen activator (PA) activity was determined in 65 atherosclerotic arteries obtained from 65 patients during surgery -42 during resection of the infrarenal part of the aorta, and 23 from a leg artery in patients undergoing a below-knee amputation. I... | ['Adult', 'Aged', 'Arteriosclerosis', 'Female', 'Fibrinolysis', 'Humans', 'Male', 'Middle Aged', 'Plasminogen Activators'] | 6,538,086 | [['M01.060.116'], ['M01.060.116.100'], ['C14.907.137.126'], ['G09.188.390.150.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D08.811.277.656.300.760.635', 'D08.811.277.656.959.350.635', 'D12.776.124.125.662']] | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Distinct roles of basal steady-state and induced H-ferritin in tumor necrosis factor-induced death in L929 cells. | Tumor necrosis factor (TNF) alpha is a cytokine capable of inducing caspase-dependent (apoptotic) cell death in some cells and caspase-independent (necrosis-like) cell death in others. Here, using a mutagenesis screen for genes critical in TNF-induced death in L929 cells, we have found that H-ferritin deficiency is res... | ['Animals', 'Apoptosis', 'Base Sequence', 'Cell Line', 'Deferoxamine', 'Dose-Response Relationship, Drug', 'Ferritins', 'Iron', 'Iron Chelating Agents', 'Mice', 'Molecular Sequence Data', 'Mutation', 'NF-kappa B', 'Reactive Oxygen Species', 'Tumor Necrosis Factor-alpha'] | 16,024,802 | [['B01.050'], ['G04.146.954.035'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['D02.092.570.394.265', 'D02.241.511.372.265'], ['G07.690.773.875', 'G07.690.936.500'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D27.505.519.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.