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Active Trigger Points Are Associated With Anxiety and Widespread Pressure Pain Sensitivity in Women, but not Men, With Tension Type Headache. | BACKGROUND: A better understanding of gender differences can assist clinicians in further developing therapeutic programs in tension type headache (TTH).OBJECTIVE: To evaluate gender differences in the presence of trigger points (TrPs) in the head, neck, and shoulder muscles and their relationship with headache feature... | ['Adult', 'Anxiety', 'Female', 'Humans', 'Hyperalgesia', 'Male', 'Middle Aged', 'Pain Threshold', 'Sensitivity and Specificity', 'Sex Characteristics', 'Tension-Type Headache', 'Trigger Points'] | 30,756,467 | [['M01.060.116'], ['F01.470.132'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.751.791.400', 'C23.888.592.763.770.400'], ['M01.060.116.630'], ['F02.463.593.710.560', 'F02.830.816.444.700', 'G11.561.790.444.700'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.72... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Use of factorial designs to optimize animal experiments and reduce animal use. | Optimization of experiments, such as those used in drug discovery, can lead to useful savings of scientific resources. Factors such as sex, strain, and age of the animals and protocol-specific factors such as timing and methods of administering treatments can have an important influence on the response of animals to ex... | ['Allyl Compounds', 'Animal Testing Alternatives', 'Animals', 'Animals, Laboratory', 'Chloramphenicol', 'Data Interpretation, Statistical', 'Dose-Response Relationship, Drug', 'Factor Analysis, Statistical', 'Female', 'Leukocyte Count', 'Leukocytes', 'Male', 'Mice', 'Models, Animal', 'Models, Statistical', 'Neoplasms, ... | 12,391,398 | [['D02.455.326.271.122'], ['E05.017.080.100'], ['B01.050'], ['B01.050.050.199'], ['D02.033.455.706.300', 'D02.455.426.559.389.565.175', 'D02.640.529.175'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.740.4... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
[Analysis of ophthalmic projects granted by National Natural Science Foundation]. | OBJECTIVE: To understand the status of basic research work in the field of ophthalmology by analyzing the projects funded by the National Natural Science Foundation of China (NSFC) from the year of 1986 to 2007, and offer as a reference to the ophthalmologists and researchers.METHODS: NSFC supported ophthalmology proje... | ['China', 'Foundations', 'Ophthalmology'] | 19,175,165 | [['Z01.252.474.164'], ['N03.219.483.311', 'N03.540.630.180'], ['H02.403.810.468']] | ['Geographicals [Z]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Multiscale feature analysis of salivary gland branching morphogenesis. | Pattern formation in developing tissues involves dynamic spatio-temporal changes in cellular organization and subsequent evolution of functional adult structures. Branching morphogenesis is a developmental mechanism by which patterns are generated in many developing organs, which is controlled by underlying molecular p... | ['Animals', 'Artificial Intelligence', 'Cell Nucleus', 'Computer Graphics', 'Epithelial Cells', 'Mesoderm', 'Mice', 'Models, Biological', 'Molecular Imaging', 'Morphogenesis', 'Protein Kinase Inhibitors', 'Reproducibility of Results', 'Salivary Glands', 'Signal Transduction', 'rho-Associated Kinases'] | 22,403,724 | [['B01.050'], ['G17.035.250', 'L01.224.050.375'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['L01.224.108', 'L01.296.110'], ['A11.436'], ['A16.504.660'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.395'], ['E01.370.350.557', 'E05.601.555'], ['G07.345.500'], ['D27.505.519.389.755'], ['E05.318.370.72... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Development of a Freeze-Dried, Heat-Stable Influenza Subunit Vaccine Formulation. | An influenza pandemic remains a major public health concern. A key strategy to prevent a pandemic is to stockpile and pre-position stable influenza vaccine to allow rapid deployment in response to an outbreak. However, most influenza vaccines today are formulated as liquids that are stable only within a temperature ran... | ['Animals', 'Chemistry, Pharmaceutical', 'Crystallization', 'Crystallography, X-Ray', 'Excipients', 'Female', 'Freeze Drying', 'Hot Temperature', 'Humans', 'Humidity', 'Influenza A Virus, H1N1 Subtype', 'Influenza Vaccines', 'Influenza, Human', 'Mice, Inbred BALB C', 'Orthomyxoviridae Infections', 'Powders', 'Vaccines,... | 27,851,765 | [['B01.050'], ['H01.158.703.007', 'H01.181.466'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D26.650.700.419', 'D27.720.744.770.419'], ['E01.370.225.500.620.760.160.260', 'E01.370.225.750.600.760.160.260', 'E02.792.156.260', 'E05.200.500.620.760.160.260', 'E05.200.750.600.760.160.260', 'E05.760.156.260'], [... | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Passive, wireless transduction of electrochemical impedance across thin-film microfabricated coils using reflected impedance. | A new method of wirelessly transducing electrochemical impedance without integrated circuits or discrete electrical components was developed and characterized. The resonant frequency and impedance magnitude at resonance of a planar inductive coil is affected by the load on a secondary coil terminating in sensing electr... | ['Electric Impedance', 'Electrochemical Techniques', 'Electrodes', 'Gold', 'Membranes, Artificial', 'Polymers', 'Wireless Technology', 'Xylenes'] | 28,948,395 | [['G01.358.500.249.277.350'], ['E05.301'], ['E07.305.250'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['L01.178.847.950'], ['D02.455.426.559.389.948']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Phase I trial of palbociclib, a selective cyclin dependent kinase 4/6 inhibitor, in combination with cetuximab in patients with recurrent/metastatic head and neck squamous cell carcinoma. | OBJECTIVES: To test the safety of the CDK4/6 inhibitor palbociclib with cetuximab in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC).MATERIALS AND METHODS: A phase I trial using 3+3 design was performed to determine the dose limiting toxicity (DLT) and maximum tolerated dose (MTD) of pa... | ['Adult', 'Aged', 'Carcinoma, Squamous Cell', 'Cetuximab', 'Cyclin-Dependent Kinase 4', 'Cyclin-Dependent Kinase 6', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Piperazines', 'Pyridines'] | 27,311,401 | [['M01.060.116'], ['M01.060.116.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['D12.776.124.486.485.114.224.060.750', 'D12.776.124.790.651.114.224.060.750', 'D12.776.377.715.548.114.224.200.750'], ['D08.811.913.696.620.682.700.646.500.875', 'D12.644.360.250.451', 'D12.776.167.200.451', 'D12.776.476.250.451'], ... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization. | Characterization of the human glucagon-receptor-encoding gene (GGR) should provide a greater understanding of blood glucose regulation and may reveal a genetic basis for the pathogenesis of diabetes. A cDNA encoding a complete functional human glucagon receptor (GGR) was isolated from a liver cDNA library by a combinat... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Chromosome Mapping', 'Chromosomes, Human, Pair 17', 'Cloning, Molecular', 'DNA', 'DNA, Complementary', 'Glucagon', 'Humans', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Rats', 'Receptors, Glucagon', 'Sequence Alignment', 'Sequence Homology, Amino Acid', ... | 8,144,028 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['A11.284.187.520.300.415.425', 'G05.360.162.520.300.415.425'], ['E05.393.220'], ['D13.444.308'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['D06.472... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Practice patterns in screening and management of prostate cancer in elderly men. | OBJECTIVES: To determine the practice preferences for prostate cancer screening and treatment in men 75 years of age or older among healthcare providers in Iowa.METHODS: Practice patterns were determined by an institutional review board-approved 15-item survey mailed to all 3105 Iowa healthcare providers who care for o... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Male', 'Mass Screening', 'Middle Aged', "Practice Patterns, Physicians'", 'Prostatic Neoplasms', 'Surveys and Questionnaires'] | 17,095,076 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['M01.060.116.630'], ['N04.590.374.577', 'N05.300.625'], ['... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Elevated levels of iron in groundwater in Prey Veng province in Cambodia: a possible factor contributing to high iron stores in women. | Iron is a natural element found in food, water and soil and is essential for human health. Our aim was to determine the levels of iron and 25 other metals and trace elements in groundwater from 22 households in Prey Veng, Cambodia. Water analyses were conducted using inductively coupled plasma-mass spectrometry and opt... | ['Cambodia', 'Female', 'Filtration', 'Groundwater', 'Humans', 'Iron', 'Metals', 'Trace Elements'] | 26,042,988 | [['Z01.252.145.182'], ['E05.196.454', 'G01.280', 'G02.263'], ['G01.311.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D01.552'], ['D01.268.811', 'D27.505.696.494.555', 'G07.203.300.681.500.555', 'J02.500.681.500.555']] | ['Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Translesion DNA synthesis across various DNA adducts produced by 3-nitrobenzanthrone in Escherichia coli. | To analyze translesion DNA synthesis (TLS) across lesions derived from the air pollutant 3-nitrobenzanthrone in Escherichia coli, we constructed site-specifically modified plasmids containing single molecule adducts derived from 3-nitrobenzanthrone. For this experiment, we adopted a modified version of the method devel... | ['Benz(a)Anthracenes', 'DNA Adducts', 'DNA Damage', 'DNA Replication', 'Escherichia coli'] | 23,583,687 | [['D02.455.426.559.847.149', 'D04.615.149'], ['D13.444.308.135', 'G05.200.104'], ['G05.200'], ['G02.111.225', 'G05.226'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endothelins (EDN1, EDN2, EDN3) and their receptors (EDNRA, EDNRB, EDNRB2) in chickens: Functional analysis and tissue distribution. | Endothelins (EDNs) and their receptors (EDNRs) are reported to be involved in the regulation of many physiological/pathological processes, such as cardiovascular development and functions, pulmonary hypertension, neural crest cell proliferation, differentiation and migration, pigmentation, and plumage in chickens. Howe... | ['Amino Acid Sequence', 'Animals', 'Chickens', 'Endothelins', 'Female', 'HEK293 Cells', 'Humans', 'Male', 'Receptors, Endothelin', 'Signal Transduction', 'Tissue Distribution'] | 31,351,053 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D12.644.276.400', 'D12.776.467.400', 'D23.529.400'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543.750.695.220', 'D12.776.543.750.750.320']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Quality of Life and Depression Level in Patients with Watery Eye. | BACKGROUND: The aim of this study was to assess subjective, human aspect of the medical condition, evaluate the quality of life (QOL) and level of depressive symptoms in patients with watery eye and compare it with patients with two most common causes of visual deterioration: cataract and macular region pathology. The ... | ['Cataract', 'Depression', 'Eye Diseases', 'Humans', 'Prospective Studies', 'Quality of Life', 'Surveys and Questionnaires', 'Visual Acuity'] | 30,439,808 | [['C11.510.245'], ['F01.145.126.350'], ['C11'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['E01.... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Coagulopathy with piperacillin administration in cystic fibrosis: two case reports. | Two cases are reported of coagulopathy in association with the administration of piperacillin to patients with cystic fibrosis. In both cases the coagulopathy was associated with the development of a serum sickness-like illness with fever, rash and abnormal liver function tests occurring on day 12 and day 16 of treatme... | ['Blood Coagulation Disorders', 'Blood Coagulation Tests', 'Child', 'Child, Preschool', 'Cystic Fibrosis', 'Drug Eruptions', 'Female', 'Humans', 'Liver Function Tests', 'Piperacillin', 'Serum Sickness'] | 8,074,918 | [['C15.378.100'], ['E01.370.225.625.115', 'E05.200.625.115'], ['M01.060.406'], ['M01.060.406.448'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['C17.800.174.600', 'C20.543.206.380', 'C25.100.468.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.372.460'], ['D02.065.589.099.750.750.050... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Morphometric analysis of fossa ovalis in rheumatic heart disease. | BACKGROUND: Rheumatic heart disease is an important cause of valvular disease in India, with resultant alterations in the interatrial septum and fossa ovalis. Morphometric details of fossa ovalis may help in its localization during transseptal catheterization so as to prevent complications.METHODS AND RESULTS: Autopsy ... | ['Adolescent', 'Adult', 'Age Factors', 'Autopsy', 'Case-Control Studies', 'Female', 'Heart Septum', 'Humans', 'Male', 'Middle Aged', 'Mitral Valve', 'Reference Values', 'Rheumatic Heart Disease', 'Sensitivity and Specificity', 'Sex Factors'] | 16,521,634 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A07.541.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.541.510.507'], ['E05.9... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Tongue necrosis due to vasculitis. | We describe a 7-year-old boy with necrosis of the tongue due to a generalized vasculitis, with symptoms and signs consistent with periarteritis nodosa and appearing after an infection with streptococci. Approximately one-third of the tongue had to be extirpated. | ['Child', 'Humans', 'Male', 'Necrosis', 'Neutrophils', 'Polyarteritis Nodosa', 'Streptococcus', 'Tongue', 'Vasculitis'] | 8,580,641 | [['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.717'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145.229.637.415.583', 'A15.382.490.315.583', 'A15.382.680.689'], ['C14.907.940.090.720', 'C14.907.940.897.500', 'C17.800.862.625'], ['B03.353.750.737.872', 'B03.510.400.800.... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. | The cdc25A phosphatase removes inhibitory phosphates from threonine-14 and tyrosine-15 of cyclin dependent kinase-2 (cdk2) in vitro, and it is therefore widely assumed that cdc25A positively regulates cyclin E- and A-associated cdk2 activity at the G1 to S phase transition of the mammalian cell division cycle. Human cd... | ['3T3 Cells', 'Animals', 'CDC2-CDC28 Kinases', 'Cell Line, Transformed', 'Cyclin-Dependent Kinase 2', 'Cyclin-Dependent Kinases', 'Gene Expression', 'Humans', 'Mice', 'Phosphorylation', 'Protein Tyrosine Phosphatases', 'Protein-Serine-Threonine Kinases', 'S Phase', 'Tyrosine', 'cdc25 Phosphatases'] | 9,989,807 | [['A11.251.210.100', 'A11.329.228.100'], ['B01.050'], ['D08.811.913.696.620.682.700.646.500.500', 'D12.644.360.250.067', 'D12.776.167.200.067', 'D12.776.476.250.067'], ['A11.251.210.172'], ['D08.811.913.696.620.682.700.646.500.750', 'D12.644.360.250.323', 'D12.776.167.200.323', 'D12.776.476.250.323'], ['D08.811.913.696... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identifying Mutations by High Resolution Melting in a TILLING Population of Rice. | Target Induced Local Lesions In Genomes (TILLING) is a strategy of reverse genetics for the high-throughput screening of induced mutations. However, the TILLING system has less applicability for insertion/deletion (Indel) detection and traditional TILLING needs more complex steps, like CEL I nuclease digestion and gel ... | ['Crops, Agricultural', 'Mutation', 'Oryza', 'Transition Temperature'] | 31,524,866 | [['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['G05.365.590'], ['B01.650.940.800.575.912.250.822.616'], ['G01.906.595.850']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Controversies in Pouch Surveillance for Patients with Inflammatory Bowel Disease. | CASE 1: Following 2 years of rectal blood loss, a 31-year-old male was diagnosed with ulcerative pancolitis in 1978. Initial treatment consisted of both topical and systemic 5-aminosalicylic acids [5-ASAs], and remission was achieved. In both 1984 and 1986 he was hospitalised due to exacerbations necessitating treatmen... | ['Adult', 'Aftercare', 'Colitis, Ulcerative', 'Colonic Pouches', 'Humans', 'Male', 'Proctitis', 'Proctocolectomy, Restorative'] | 26,822,612 | [['M01.060.116'], ['E02.760.169.063', 'N02.421.585.169.063', 'N04.590.233.727.210.063'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['A10.850.200', 'E07.862.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.205.865', 'C06.405.469.860.622'], ['E04.21... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinical features and prognosis of acute aortic intramural hemorrhage compared with those of acute aortic dissection: a single center experience. | The clinical manifestations and natural history of acute aortic intramural hemorrhage are not well characterized. Therefore, we have evaluated the differences in the clinical features and prognosis between acute intramural hemorrhage and acute classic aortic dissection. One hundred two consecutive patients with acute a... | ['Acute Disease', 'Aged', 'Aneurysm, Dissecting', 'Aortic Aneurysm', 'Female', 'Hemorrhage', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Survival Rate', 'Treatment Outcome'] | 11,324,810 | [['C23.550.291.125'], ['M01.060.116.100'], ['C14.907.055.050'], ['C14.907.055.239', 'C14.907.109.139'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['E05.318.308.985.550.900', 'N01.224.935.698.826', 'N06.850.505.400.975.550.900', 'N06.850.520.308.985.550.900'], ['... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cardiac sounds from a wearable device for sternal seismocardiography. | Seismocardiography is the body-surface recording of vibrations produced by the beating heart. A high frequency (HF) accelerometric component of the seismocardiogram (SCG) is related to the heart sounds generated by the closure of atrio-ventricular and semilunar valves. This paper evaluates the feasibility of recording ... | ['Acceleration', 'Electrocardiography', 'Feasibility Studies', 'Humans', 'Sternum'] | 22,255,286 | [['G01.482.107'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.570.750']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Venous thromboembolism is a relevant and underestimated adverse event in cancer patients treated in phase I studies. | BACKGROUND: To investigate, retrospectively, the role of tumour histotype and antiangiogenic drugs for venous thromboembolism (VTE) development in advanced cancer patients treated in phase I studies.METHODS: Patients enrolled and treated in phase I studies conducted by SENDO (Southern Europe New Drugs Organisation) wer... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Combined Chemotherapy Protocols', 'Clinical Trials, Phase I as Topic', 'Female', 'Humans', 'Incidence', 'Leukocytosis', 'Male', 'Middle Aged', 'Neoplasms', 'Retrospective Studies', 'Risk', 'Venous Thromboembolism', 'Young Adult'] | 22,828,607 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E05.318.372.250.250.200', 'N05.715.360.330.250.250.200', 'N06.850.520.450.250.250.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Subxiphoid cross-sectional echocardiography in infants and children with congenital heart disease. | We developed anatomically related cross-sectional echocardiographic views to image the heart from the subxiphoid area in 100 children and infants with various forms of congenital heart disease studied prospectively before cardiac catheterization. Wide-angle cross-sectional views were achieved using a mechanical sector ... | ['Child, Preschool', 'Coronary Circulation', 'Echocardiography', 'Heart Defects, Congenital', 'Heart Septal Defects, Atrial', 'Heart Septal Defects, Ventricular', 'Humans', 'Tetralogy of Fallot', 'Transposition of Great Vessels'] | 761,331 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantitation of the diastereoisomers of L-buthionine-(R,S)-sulfoximine in human plasma: a validated assay by capillary electrophoresis. | An assay for the diastereoisomers of the biochemical modifier L-buthionine-(R,S)-sulfoximine (BSO) in human plasma has been developed using capillary electrophoresis (CE). Separation of the diastereoisomers is achieved by the micellar electrokinetic chromatography (MEKC) mode of CE. Plasma is injected directly onto the... | ['Electrophoresis, Capillary', 'Enzyme Inhibitors', 'Glutamate-Cysteine Ligase', 'Humans', 'Hydrogen-Ion Concentration', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Sodium Dodecyl Sulfate', 'Spectrophotometry, Ultraviolet', 'Stereoisomerism'] | 8,925,065 | [['E05.196.401.190', 'E05.301.300.190'], ['D27.505.519.389'], ['D08.811.464.259.850.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Evidence for a repetitive (burst) firing pattern in a sub-population of 5-hydroxytryptamine neurons in the dorsal and median raphe nuclei of the rat. | Previous electrophysiological studies have shown that spontaneously active mesencephalic 5-hydroxytryptaminergic neurons of anaesthetized or freely moving animals fire solitary spikes in a slow, regular pattern. In the present study, using extracellular single unit recordings from dorsal and median raphe neurons of the... | ['8-Hydroxy-2-(di-n-propylamino)tetralin', 'Anesthetics', 'Animals', 'Electrophysiology', 'Male', 'Neurons', 'Paroxetine', 'Raphe Nuclei', 'Rats', 'Rats, Sprague-Dawley', 'Serotonin', 'Serotonin Receptor Agonists', 'Serotonin Uptake Inhibitors'] | 8,637,617 | [['D02.455.426.559.847.638.960.400', 'D04.615.638.960.400'], ['D27.505.696.277.100', 'D27.505.954.427.210.100'], ['B01.050'], ['H01.158.344.528', 'H01.158.782.236'], ['A08.675', 'A11.671'], ['D03.383.621.600'], ['A08.186.211.132.659.413.875.618', 'A08.186.211.132.810.428.600.650.562', 'A08.186.211.132.810.591.500.662']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Antigenic Detection of Human Strain of Influenza Virus A (H3N2) in Swine Populations at Three Locations in Nigeria and Ghana during the Dry Early Months of 2014. | Since the first detection of human H3N2 influenza virus in Taiwanese pigs in 1970, infection of pigs with wholly human viruses has been known to occur in other parts of the world. These viruses, referred to as human-like H3N2 viruses, have been known to cause clinical and subclinical infections of swine populations. Du... | ['Animal Husbandry', 'Animals', 'Antigens, Viral', 'Enzyme-Linked Immunosorbent Assay', 'Ghana', 'Humans', 'Influenza A Virus, H3N2 Subtype', 'Influenza, Human', 'Nasal Septum', 'Nigeria', 'Orthomyxoviridae Infections', 'Seasons', 'Surveys and Questionnaires', 'Swine', 'Swine Diseases', 'Zoonoses'] | 26,094,828 | [['J01.040.090'], ['B01.050'], ['D23.050.327'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['Z01.058.290.190.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B04.820.480.968.405.400.300'], ['C01.748.310', 'C01.925.782.620.365', 'C08.730.... | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Benign hormone-secreting adenoma within a larger adrenocortical mass showing intensely increased activity on 18 | Adrenal adenomas usually show 18F-FDG activity less than that of the liver parenchyma. However, lipid-poor and hormone-secreting adenomas have been reported to show mild 18F-FDG avidity. We report on a 51-year-old female with clinical symptoms of hypercortisolemia and a large right adrenal mass detected on CT. Post-con... | ['Adenoma', 'Adrenal Cortex Neoplasms', 'Female', 'Fluorodeoxyglucose F18', 'Humans', 'Middle Aged', 'Positron Emission Tomography Computed Tomography'] | 27,154,873 | [['C04.557.470.035'], ['C04.588.322.078.265', 'C19.053.098.265', 'C19.053.347.500', 'C19.344.078.265'], ['D09.254.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.350.800.700.500', 'E01.370.350.350.810.645', 'E01.370.350.567.500', 'E01.370.350.600.350.700.810.490', 'E01.370... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nordihydroguaiaretic acid attenuates the oxidative stress-induced decrease of CD33 expression in human monocytes. | Nordihydroguaiaretic acid (NDGA) is a natural lignan with recognized antioxidant and beneficial properties that is isolated from Larrea tridentata. In this study, we evaluated the effect of NDGA on the downregulation of oxidant stress-induced CD33 in human monocytes (MNs). Oxidative stress was induced by iodoacetate (I... | ['Antioxidants', 'Cell Survival', 'Cells, Cultured', 'Down-Regulation', 'Glutathione', 'Humans', 'Hydrogen Peroxide', 'Iodoacetates', 'Larrea', 'Masoprocol', 'Monocytes', 'Oxidative Stress', 'Reactive Oxygen Species', 'Sialic Acid Binding Ig-like Lectin 3'] | 23,533,689 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G04.346'], ['A11.251'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D12.644.456.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['D02.241.0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Truncated-view artifacts: clinical importance on CT. | A truncated-view artifact in CT is produced whenever any part of the patient or imaged object is present in some but not all of the views obtained for a slice. The potential to create images with this artifact exists for any CT scanner in which the fan beam (or its equivalent) does not cover the entire gantry aperture.... | ['Humans', 'Models, Structural', 'Radiographic Image Enhancement', 'Tomography, X-Ray Computed'] | 6,602,518 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.280.500.545', 'L01.178.820.090.545'], ['E01.370.350.600.350.700', 'E01.370.350.700.700', 'L01.224.308.380.600'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Active trachoma and community use of sanitation, Ethiopia. | OBJECTIVE: To investigate, in Amhara, Ethiopia, the association between prevalence of active trachoma among children aged 1-9 years and community sanitation usage.METHODS: Between 2011 and 2014, prevalence of trachoma and household pit latrine usage were measured in five population-based cross-sectional surveys. Data o... | ['Anti-Bacterial Agents', 'Child', 'Child, Preschool', 'Cross-Sectional Studies', 'Ethiopia', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Infant', 'Logistic Models', 'Male', 'Odds Ratio', 'Prevalence', 'Sanitation', 'Toilet Facilities', 'Trachoma'] | 28,479,620 | [['D27.505.954.122.085'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['Z01.058.290.120.310'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.740.500.525', 'E05.318.740.600.800.4... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]',... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
Weakness and 'tiredness': when to suspect myasthenia gravis. | Initial complaints of bulbar paresis may be problems with chewing and swallowing. Patients often choose to eat soft puddings and cereals rather than meats or hard fruits because of the fatigue associated with chewing. Immunosuppressive therapy with prednisone can result in a long-lasting remission, and is recommended e... | ['Aged', 'Antibodies', 'Diagnosis, Differential', 'Edrophonium', 'Electromyography', 'Fatigue', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myasthenia Gravis', 'Physical Examination', 'Plasmapheresis', 'Prednisone', 'Receptors, Cholinergic', 'Thymectomy'] | 3,965,358 | [['M01.060.116.100'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['E01.171'], ['D02.092.877.674.333', 'D02.675.276.352'], ['E01.370.405.255', 'E01.370.530.255'], ['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.614.550.500', 'C04.73... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Adult right lobe live donor liver transplantation without reconstruction of the middle hepatic vein: a single-center study of 109 cases. | We report our experience in adult-to-adult right hepatic lobe living donor liver transplantation (ALDLT) using extension of the hepatectomy transection line medially to incorporate the right middle hepatic vein branches into the donor graft. One hundred and nine ALDLT were performed at the University of Colorado from A... | ['Functional Laterality', 'Graft Survival', 'Hepatectomy', 'Hepatic Veins', 'Humans', 'Liver Transplantation', 'Living Donors', 'Retrospective Studies', 'Survival Analysis', 'Tissue and Organ Harvesting'] | 18,337,674 | [['F02.830.297.425', 'G11.561.225.425'], ['G12.875.545.340'], ['E04.210.556'], ['A07.015.908.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['M01.898.656'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.... | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Risk of clot formation in femoral arterial sheaths maintained overnight for neuroangiographic procedures. | BACKGROUND AND PURPOSE: The purpose of this study was to evaluate the presence of blood clots in femoral arterial sheaths maintained after cerebral angiography and the effect of heparinized saline on clot formation.METHODS: Twenty-three sheaths were evaluated in 18 patients. Sheaths were maintained for 14 to 80 hours (... | ['Adolescent', 'Adult', 'Aged', 'Blood Coagulation', 'Catheterization, Peripheral', 'Cerebral Angiography', 'Female', 'Femoral Artery', 'Heparin', 'Humans', 'Male', 'Middle Aged', 'Risk Factors', 'Sodium Chloride', 'Thromboembolism', 'Time Factors'] | 10,094,358 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['G09.188.390.150'], ['E02.148.224', 'E04.100.814.529.937', 'E04.502.382.937', 'E05.157.375'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700.560.180', 'E01.370.370.050.180', 'E01.370.376.537.750.180', 'E05.629.937.180'], ['A07.015.114.351... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Research survey on the information gathering methods, attitudes, and requests from care managers about the pharmaceutical service by pharmacists in home care]. | Care Managers (CMs) were surveyed to clarify the issues involving the promotion of cooperation between care managers and pharmacists in long-term-care and explore solutions. The length of work experience, occupational background, experience of pharmaceutical service; pharmacist visit patients' home for providing medici... | ['Home Care Services', 'House Calls', 'Humans', 'Long-Term Care', 'Patient Care Management', 'Patient Care Planning', 'Pharmaceutical Services', 'Pharmacies', 'Pharmacists'] | 21,532,281 | [['N02.421.143.524', 'N02.421.539.089'], ['N04.452.758.307'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.476', 'N02.421.585.476'], ['N04.590'], ['N04.590.233.624'], ['N02.421.668'], ['N02.278.678'], ['M01.526.485.780', 'N02.360.780']] | ['Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Synthesis of fluorescent C2-bridged teraryls and quateraryls for blue, sky-blue, and green color light-emitting devices. | A series of fluorescent teraryls and quateraryls were prepared from a ketene-S,S-acetal under mild conditions. These compounds exhibited blue, sky-blue and green color emissions both in the solid state and in a solution with good quantum yields, positive solvatochromic behavior, and reversible oxidation and reduction p... | ['Acetals', 'Electronics', 'Fluorescent Dyes', 'Ketones', 'Light', 'Luminescent Agents', 'Molecular Structure', 'Quantum Theory'] | 25,340,860 | [['D02.355.071'], ['H01.671.293'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D02.522'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['D27.720.470.410.505'], ['G02.111.570', 'G02.466'], ['H01.671.579.800']] | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Mesalazine-induced lupus. | We report a case of lupus induced by mesalazine therapy taken for over a year for Crohn's disease. The patient had polyarthritis, alopecia, lymphoneutropenia, antinuclear factors, anti-histone antibodies, anti-Sm and anti-RNP. Discontinuation of mesalazine was followed by rapid resolution of the joint manifestations, a... | ['Anti-Inflammatory Agents, Non-Steroidal', 'Crohn Disease', 'Diagnosis, Differential', 'Female', 'Follow-Up Studies', 'Glucocorticoids', 'Humans', 'Lupus Vulgaris', 'Mesalamine', 'Middle Aged'] | 9,385,697 | [['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['E01.171'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['B01.050.150.900.649.313.988.400.11... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ethanol-induced alterations in lymphocyte function in the guinea pig. | Infections and chronic liver injury are common causes of morbidity and mortality in alcoholics, and both of these may be related to an altered immune response. This study describes a guinea pig model of chronic ethanolism designed to selectively study the cellular immune system in a setting free from the malnutrition, ... | ['Animals', 'Ethanol', 'Guinea Pigs', 'Leukocyte Count', 'Lymphocyte Activation', 'Lymphocytes', 'Macrophage Migration-Inhibitory Factors', 'Skin Tests'] | 6,370,025 | [['B01.050'], ['D02.033.375'], ['B01.050.150.900.649.313.992.550'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.200.625.107.595', 'E05.242.195.107.595', 'G04.140.107.595', 'G09.188.105.595'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.54... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nanoformulation of paclitaxel to enhance cancer therapy. | UNLABELLED: Paclitaxel is a microtubule inhibitor causing mitotic arrest and is widely used in cancer chemotherapy. However, its poor water solubility restricts its direct clinical applications. In this article, we report paclitaxel-loaded nanoparticles that are water soluble and that can improve the drug's bio-distrib... | ['Antineoplastic Agents, Phytogenic', 'Cell Line, Tumor', 'Drug Carriers', 'HeLa Cells', 'Humans', 'Nanoparticles', 'Neoplasms', 'Paclitaxel', 'Poloxamer'] | 22,561,979 | [['D27.505.954.248.179'], ['A11.251.210.190', 'A11.251.860.180'], ['D26.255.260', 'E02.319.300.380'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.637.512.600'], ['C04'], ['D02.455.426.392.368.242.888.777', 'D02.455.849.291.850.777'], ['D02.033.45... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effect of supplemental dietary glutamine on methotrexate concentrations in tumors. | This study evaluated the effects of supplemental dietary glutamine (GLN) on methotrexate sodium concentrations in tumors and serum of sarcoma-bearing rats following the initiation of methotrexate. After randomization to a GLN diet (+GLN) or GLN-free diet (-GLN), tumor-bearing rats received 20 mg/kg of methotrexate sodi... | ['Animals', 'Body Weight', 'Disease Models, Animal', 'Drug Evaluation, Preclinical', 'Drug Synergism', 'Energy Intake', 'Glutamine', 'Humans', 'Male', 'Methotrexate', 'Rats', 'Rats, Inbred F344', 'Sarcoma, Experimental'] | 1,444,793 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.290.750', 'E05.337.550'], ['G07.690.773.968.477'], ['G07.203.650.240.340'], ['D12.125.068.330', 'D12.125.095.461', 'D12.125.154.424'], [... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differences in risk of malignancy and management recommendations in subcategories of thyroid nodules with atypia of undetermined significance or follicular lesion of undetermined significance: the role of ultrasound-guided core-needle biopsy. | BACKGROUND: The cytopathologic description of atypia of undetermined significance (AUS)/follicular lesion of undetermined significance (FLUS) includes nine different criteria in The Bethesda System, and the risk of malignancy in this category shows a wide range. The objectives of the present study were to determine whe... | ['Adenocarcinoma, Follicular', 'Adult', 'Biopsy, Large-Core Needle', 'Female', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Thyroid Gland', 'Thyroid Neoplasms', 'Thyroid Nodule', 'Ultrasonography, Interventional'] | 23,947,771 | [['C04.557.470.200.025.060'], ['M01.060.116'], ['E01.370.225.500.384.100.119.750', 'E01.370.225.998.054.119.750', 'E01.370.388.100.100.750', 'E04.074.119.750', 'E04.665.100.750', 'E05.200.500.384.100.119.750', 'E05.200.998.054.119.750', 'E05.242.384.100.119.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Effect of different doses of sufentanil on stress responses to tracheal intubation in patients undergoing heart valve replacement surgery]. | OBJECTIVE: To determine the effect of different doses of sufentanil on stress responses to tracheal intubation in patients undergoing heart valve replacement surgery.METHODS: Sixty patients undergoing heart valve replacement surgery were randomly divided into 4 groups (n=15). Before the tracheal intubation, patients re... | ['Adjuvants, Anesthesia', 'Adolescent', 'Adult', 'Dose-Response Relationship, Drug', 'Female', 'Heart Valve Diseases', 'Heart Valve Prosthesis Implantation', 'Hemodynamics', 'Humans', 'Intubation, Intratracheal', 'Male', 'Middle Aged', 'Stress, Physiological', 'Sufentanil', 'Treatment Outcome'] | 17,611,335 | [['D27.505.954.427.010'], ['M01.060.057'], ['M01.060.116'], ['G07.690.773.875', 'G07.690.936.500'], ['C14.280.484'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['M01.060.116.630'], ['G07.775'], [... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Is TRAP-6 suitable as a positive control for platelet reactivity when assessing response to clopidogrel? | Adenosine 5′-diphosphate (ADP) inducible aggregation is used to assess platelet response to thienopyridines. Thrombin receptor-activating peptide-6 (TRAP-6) inducible aggregation may serve as a positive control because it acts via the thrombin receptor protease-activating receptor-1, which is not blocked by thienopyrid... | ['Adenosine Diphosphate', 'Aged', 'Blood Platelets', 'Cell Adhesion Molecules', 'Clopidogrel', 'Female', 'Humans', 'Male', 'Microfilament Proteins', 'Peptide Fragments', 'Phosphoproteins', 'Platelet Aggregation', 'Platelet Aggregation Inhibitors', 'Platelet Function Tests', 'Ticlopidine'] | 20,624,009 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['M01.060.116.100'], ['A11.118.188', 'A15.145.229.188'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['D02.886.778.823.500.500', 'D03.383.725.849.500.500', 'D03.383.903.830.500.500', 'D03.633.100.928.500.500'], ['B01.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Activity of CMP-2-keto-3-deoxyoctulosonic acid synthetase in Escherichia coli strains expressing the capsular K5 polysaccharide implication for K5 polysaccharide biosynthesis. | The activity of the cytoplasmic CMP-2-keto-3-deoxyoctulosonic acid synthetase (CMP-KDO synthetase), which is low in Escherichia coli rough strains such as E. coli K-12 and in uncapsulated strains such as E. coli O111, was significantly elevated in encapsulated E. coli O10:K5 and O18:K5. This enzyme activity was even hi... | ['Cloning, Molecular', 'Cytosol', 'Escherichia coli', 'Genes, Bacterial', 'Hexosyltransferases', 'Nucleotidyltransferases', 'Polysaccharides, Bacterial', 'Restriction Mapping', 'Temperature'] | 2,542,215 | [['E05.393.220'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['D08.811.913.400.450'], ['D08.811.913.696.445'], ['D09.698.718', 'D23.050.161.616'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of Individual and Combined Treatments of Pesticide, Fertilizer, and Salt on Growth and Corticosterone Levels of Larval Southern Leopard Frogs (Lithobates sphenocephala). | Human activities have introduced a variety of chemicals, including pesticides, fertilizers, and salt, into the environment, which may have deleterious effects on the organisms inhabiting these areas. Amphibians are especially susceptible to absorption of chemical pollutants. To determine the possible combined effects o... | ['Animals', 'Atrazine', 'Corticosterone', 'Female', 'Fertilizers', 'Larva', 'Metamorphosis, Biological', 'Nitrates', 'Periphyton', 'Pesticides', 'Phytoplankton', 'Rana pipiens', 'Sodium Chloride', 'Water Pollutants, Chemical'] | 31,020,372 | [['B01.050'], ['D03.383.931.247'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['D27.720.031.400'], ['B05.500.500', 'G07.345.500.550.500.500'], ['G07.345.500.550'], ['D01.248.497.158.606', 'D01.625.525.550', 'D02.583'], ['B05.080.250', 'G06.591.937', 'G16.500.275.157.049.100.500.937', 'N06.230.124.049.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Traumatic wound dehiscence after corneal graft. | BACKGROUND AND OBJECTIVE: Any trauma to a corneal transplanted eye is likely to lacerate the corneal wound because of persistent wound weakness, even years after keratoplasty. We evaluate the risks and consequences of trauma after penetrating keratoplasty (PKP).METHODS: Records of 11 patients who had been treated in ou... | ['Adolescent', 'Adult', 'Aged', 'Corneal Injuries', 'Eye Injuries', 'Female', 'Humans', 'Keratoplasty, Penetrating', 'Lens, Crystalline', 'Male', 'Middle Aged', 'Risk Factors', 'Surgical Wound Dehiscence', 'Time Factors', 'Treatment Outcome', 'Visual Acuity', 'Wounds, Nonpenetrating'] | 11,725,770 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C10.900.300.284.250.124', 'C11.204.284', 'C11.297.374', 'C26.915.300.425.250.124'], ['C10.900.300.284.250', 'C11.297', 'C26.915.300.425.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.147.725.225.350', 'E04.540.825.374.350', 'E04.936.580.225.35... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A comparative clinical trial of artemether and quinine in children with severe malaria. | OBJECTIVE: To compare the efficacy of artemether and quinine in the treatment of severe malaria in hospitalized children.STUDY DESIGN: Open randomized trial.SETTING: Pediatric ward of a tertiary care center.METHODS: All children admitted with clinical manifestations of severe malaria (as per WHO criteria) and asexual f... | ['Adolescent', 'Antimalarials', 'Artemether', 'Artemisinins', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Malaria', 'Male', 'Prospective Studies', 'Quinine', 'Sesquiterpenes', 'Survival Analysis', 'Treatment Outcome'] | 14,581,730 | [['M01.060.057'], ['D27.505.954.122.250.100.085'], ['D01.248.497.158.685.750.212.250', 'D01.339.431.374.212.250', 'D01.650.550.750.200.250', 'D02.389.338.055.250', 'D02.455.849.765.211.250'], ['D01.248.497.158.685.750.212', 'D01.339.431.374.212', 'D01.650.550.750.200', 'D02.389.338.055', 'D02.455.849.765.211'], ['M01.0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Stoichiometric and microenvironmental effects on hydrolysis of propantheline and oxyphenonium bromides in cyclodextrin solutions. | The effects of alpha-, beta-, and gamma-cyclodextrins (CDs) on the basic hydrolysis of propantheline bromide (PB) and oxyphenonium bromide (OB) are analyzed in terms of the stoichiometry and microenvironments of their complexes. The rate constant of each species is evaluated with binding constant data for the 1:1, 1:2,... | ['Binding Sites', 'Cyclodextrins', 'Environment', 'Hydrolysis', 'Models, Molecular', 'Oxyphenonium', 'Propantheline', 'Solutions', 'Spectrophotometry, Ultraviolet'] | 11,357,177 | [['G02.111.570.120'], ['D04.345.103', 'D09.301.915.400.375', 'D09.698.365.855.400.375'], ['G16.500.275', 'N06.230'], ['G02.380'], ['E05.599.595'], ['D02.092.877.648', 'D02.675.276.648'], ['D02.092.877.700', 'D02.675.276.700', 'D03.633.300.953.558'], ['D26.776'], ['E05.196.712.726.802', 'E05.196.867.826.802']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Trauma, depression, coping, and mental health service seeking among impoverished women. | The authors examined the relationship among trauma, coping, depression, and mental health service seeking in a probability sample of sheltered homeless and low-income housed women. Results highlight the diversity of trauma. In a longitudinal analysis, women who lived in shelters or experienced major violence had a twof... | ['Adaptation, Psychological', 'Adolescent', 'Adult', 'Cross-Sectional Studies', 'Depression', 'Female', 'Follow-Up Studies', 'Homeless Persons', 'Humans', 'Middle Aged', 'Patient Acceptance of Health Care', 'Stress Disorders, Post-Traumatic'] | 16,173,854 | [['F01.058'], ['M01.060.057'], ['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.145.126.350'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['M01.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cellular aging dynamics after acute malaria infection: A 12-month longitudinal study. | Accelerated cellular aging and reduced lifespan have recently been shown in birds chronically infected with malaria parasites. Whether malaria infection also affects cellular aging in humans has not been reported. Here, we assessed the effect of a single acute Plasmodium falciparum malaria infection on cellular aging d... | ['Adult', 'Aged', 'Cellular Senescence', 'Female', 'Humans', 'Longevity', 'Longitudinal Studies', 'Malaria', 'Male', 'Middle Aged', 'Telomerase', 'Telomere'] | 29,143,441 | [['M01.060.116'], ['M01.060.116.100'], ['G04.043'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.345.124.519', 'G07.540'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['C01.610.752.530', 'C01.920.875'], ['M01.060.116.630'], ['D08.811.913.696.445.308.300.750.750',... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Neuropeptide Y immunoreactivity in the hamster geniculo-suprachiasmatic tract. | The distributions of neuropeptide Y (NPY) and avian pancreatic polypeptide (APP) immunoreactivity were examined in the suprachiasmatic nucleus and the geniculate area of male golden hamster brains. In some cases, colchicine was injected intraventricularly to aid in visualization of immunoreactive cell bodies. A group o... | ['Animals', 'Cricetinae', 'Geniculate Bodies', 'Male', 'Mesocricetus', 'Nerve Tissue Proteins', 'Neuropeptide Y', 'Pancreatic Polypeptide', 'Suprachiasmatic Nucleus', 'Visual Pathways'] | 3,840,718 | [['B01.050'], ['B01.050.150.900.649.313.992.635.075.250'], ['A08.186.211.200.317.826.701.444'], ['B01.050.150.900.649.313.992.635.075.250.500'], ['D12.776.631'], ['D12.644.400.500', 'D12.776.631.650.500'], ['D06.472.699.587.700', 'D12.644.400.600', 'D12.644.548.586.700', 'D12.776.631.650.600'], ['A08.186.211.180.497.34... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The island thoracoacromial artery muscle perforator flap. | Descriptions of muscle perforator flaps incorporating the same skin territory of almost all known musculocutaneous flaps reflect their versatility. The pectoralis major musculocutaneous flap is a proven "workhorse" flap, especially for head and neck reconstruction. Yet, the corresponding thoracoacromial artery muscle p... | ['Adult', 'Aged', 'Arteries', 'Chin', 'Female', 'Humans', 'Male', 'Neck', 'Pectoralis Muscles', 'Reconstructive Surgical Procedures', 'Surgical Flaps'] | 21,042,182 | [['M01.060.116'], ['M01.060.116.100'], ['A07.015.114'], ['A01.456.505.259', 'A02.835.232.781.324.502.632.130', 'A14.521.632.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.598'], ['A02.633.567.775'], ['E04.680'], ['A10.850.710', 'E07.862.710']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Alternate-day treatment with S-1 in patients with gastric cancer: a retrospective study of strategies for reducing toxicity. | BACKGROUND: In patients with adverse events of S-1, the dose is generally reduced or the treatment cycle is shortened. Whether the therapeutic effectiveness of modified regimens is similar to that of the standard dosage remains unclear.METHODS: We retrospectively studied patients with gastric cancer who received S-1 on... | ['Adult', 'Aged', 'Antimetabolites, Antineoplastic', 'Chemotherapy, Adjuvant', 'Disease-Free Survival', 'Drug Administration Schedule', 'Drug Combinations', 'Female', 'Gastrectomy', 'Humans', 'Kaplan-Meier Estimate', 'Lymph Node Excision', 'Male', 'Middle Aged', 'Oxonic Acid', 'Palliative Care', 'Retrospective Studies'... | 20,195,683 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['E02.186.170', 'E02.319.170'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['E02.319.283'], ['D26... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Apoptosis-associated changes in the glycerophospholipid composition of hematopoietic progenitor cells monitored by 31P NMR spectroscopy and MALDI-TOF mass spectrometry. | Apoptosis, or programmed cell death, plays an important role in development and in tissue homeostasis and is assumed to be accompanied by changes in the composition of cellular glycerophospholipids (GPL). We have applied a combination of 31P nuclear magnetic resonance spectroscopy and matrix-assisted laser desorption a... | ['Apoptosis', 'Biochemistry', 'Ethanolamines', 'Glycerol', 'Glycerophospholipids', 'Hematopoietic Stem Cells', 'Humans', 'Interleukin-3', 'Lipids', 'Magnetic Resonance Spectroscopy', 'Mass Spectrometry', 'Phospholipids', 'Phosphorylcholine', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'] | 17,919,519 | [['G04.146.954.035'], ['H01.158.201', 'H01.181.122'], ['D02.033.100.291', 'D02.033.375.291', 'D02.092.063.291'], ['D02.033.800.875.500', 'D09.853.875.500'], ['D10.570.755.375.760.400'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.410.240.400', 'D... | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription. | XPB is a subunit of the basal transcription factor TFIIH, which is also involved in nucleotide excision repair (NER) and potentially in cell cycle regulation. A frameshift mutation in the 3'-end of the XPB gene is responsible for a concurrence of two disorders: xeroderma pigmentosum (XP) and Cockayne's syndrome (CS). W... | ['Amino Acid Sequence', 'Antibodies, Monoclonal', 'Base Sequence', 'Cell Line', 'DNA Helicases', 'DNA Repair', 'Humans', 'Immunoblotting', 'Kinetics', 'Lymphocytes', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Oligodeoxyribonucleotides', 'Peptide Fragments', 'Recombinant Proteins', 'Transcription Factor T... | 8,663,148 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['D08.811.277.040.025.159', 'D08.811.399.340'], ['G02.111.222', 'G05.219'], ['B01.050.150.900.649.313.98... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[The forensic medical expertise of the holy relics of the righteous martyr Anastasiya of Uglich]. | This article was designed to report the results of the comprehensive (historical-archival, forensic anthropological, and molecular-genetic) investigation into the holy relics of the righteous martyr Anastasiya of Uglich. The well-reasoned expert conclusion contains the scientifically sound data on the prescription of t... | ['Burial', 'Cadaver', 'Cause of Death', 'Forensic Anthropology', 'Humans', 'Saints', 'Skeleton'] | 31,213,588 | [['I01.076.201.450.550.150'], ['C23.550.260.224'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['I01.076.368.400', 'I01.198.780.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.844.188.715'], ['A02.835']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Humanities [K]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability. | Tumor necrosis factor (TNF)-alpha, a major proinflammatory cytokine, triggers endothelial cell activation and barrier dysfunction which are implicated in the pathogenesis of pulmonary edema associated with acute lung injury syndromes. The mechanisms of TNF-alpha-induced vascular permeability are not completely understo... | ['Actins', 'Adherens Junctions', 'Animals', 'Antineoplastic Agents, Phytogenic', 'Apoptosis', 'Cells, Cultured', 'Cytoskeleton', 'Electric Impedance', 'Endothelium, Vascular', 'Enzyme Activation', 'Enzyme Inhibitors', 'Humans', 'Imidazoles', 'Immunohistochemistry', 'Microtubules', 'Mitogen-Activated Protein Kinases', '... | 12,707,013 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['A11.284.149.165.420.020'], ['B01.050'], ['D27.505.954.248.179'], ['G04.146.954.035'], ['A11.251'], ['A11.284.430.214.190.750'], ['G01.358.500.249.277.350'], ['A07.015.700.500', 'A10.272.491.355'], ['G02.111.263', 'G03.328'], ['D27.505.519.389'], ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
On the identity of Tettigonia krugeri Massa from Libya with some remarks on variability of Tettigonia species (Orthoptera: Tettigoniidae; Tettigoniinae). | Morphological and genetic data allowed the authors to resurrect the name Tettigonia krugeri Massa, 1998 as a valid species. It is currently known only from two specimens (one male and one female) collected in Cirenaica (Libya). | ['Animal Distribution', 'Animals', 'Female', 'Libya', 'Male', 'Orthoptera'] | 31,716,748 | [['F01.145.113.069', 'G16.049'], ['B01.050'], ['Z01.058.266.513'], ['B01.050.500.131.617.678']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
[Morphological and biochemical adaptations to feeding in some herbivorous gastropods]. | Diet and feeding modes as well as morphological and biochemical adaptations to feeding are analyzed in herbivorous mollusks. The content of hemoglobin in radular tissues and weight properties of the radula are evaluated for different modes of feeding. | ['Adaptation, Physiological', 'Animals', 'Body Weight', 'Feeding Behavior', 'Snails'] | 15,768,636 | [['G07.025', 'G16.012.500'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.500.644.400.750']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors Associated With Sleep Quality in Patients With Chronic Widespread Pain Attending Multidisciplinary Treatment. | PURPOSE: (1) To investigate the prevalence of poor sleep quality and (2) to explore the associations between clinical, cognitive, and emotional factors and quality of sleep in patients with chronic widespread pain (CWP) receiving multidisciplinary treatment.METHOD: Baseline data were used from 163 patients with CWP ref... | ['Adult', 'Anxiety', 'Catastrophization', 'Chronic Pain', 'Fatigue', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prevalence', 'Sleep', 'Sleep Wake Disorders'] | 31,999,892 | [['M01.060.116'], ['F01.470.132'], ['F01.100.575', 'F01.470.132.225'], ['C23.888.592.612.274'], ['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['F02.830.855', 'G11.56... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A proteomic analysis of seed development in Brassica campestri L. | To gain insights into the protein dynamics during seed development, a proteomic study on the developing Brassica campestri L. seeds with embryos in different embryogenesis stages was carried out. The seed proteins at 10, 16, 20, 25 and 35 DAP (days after pollination), respectively, were separated using two-dimensional ... | ['Brassica', 'Cluster Analysis', 'Plant Proteins', 'Proteome', 'Proteomics', 'Seeds'] | 23,189,193 | [['B01.650.940.800.575.912.250.157.200'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['D12.776.765'], ['D12.776.817'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500.775']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Influence of intra-articular neutrophils on the effects of photodynamic therapy for murine MRSA arthritis. | Although there have been some reports about the cytotoxic effects of photodynamic therapy (PDT) on multidrug-resistant bacteria, there have been few reports in which favorable results of PDT on a local infection site are described. This study aimed to verify the hypothesis that the low efficacy of PDT on a local infect... | ['Animals', 'Anti-Infective Agents', 'Arthritis', 'Cell Death', 'Dihematoporphyrin Ether', 'Leukocytes', 'Methicillin-Resistant Staphylococcus aureus', 'Mice', 'Neutrophils', 'Photochemotherapy', 'Staphylococcal Infections'] | 19,947,969 | [['B01.050'], ['D27.505.954.122'], ['C05.550.114'], ['G04.146'], ['D03.383.129.578.840.500.462.400.200', 'D03.633.400.909.500.462.400.200', 'D04.345.783.500.462.400.200', 'D23.767.727.462.400.200'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['B03.300.390.400.800.750.100.500', 'B03.353.500.750.750.100.500', 'B0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The establishment of essential and metabolically derived amino acid profiles in developing chick embryo organs. | The accumulation of certain essential and metabolically derived amino acids in the free amino acid pools of three excitable tissues has been studied in the chick embryo. Valine together with leucine are at the onset present in the yolk at higher concentrations than any of the other essential amino acids. By 15 days all... | ['Amino Acids', 'Animals', 'Blood Vessels', 'Brain', 'Chick Embryo', 'Eye', 'Heart', 'Myocardium', 'Vitelline Membrane'] | 3,173,622 | [['D12.125'], ['B01.050'], ['A07.015'], ['A08.186.211'], ['A13.350.150', 'A16.331.200'], ['A01.456.505.420', 'A09.371'], ['A07.541'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['A16.690.886']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Toxicity of aerosol propellants in the respiratory and circulatory systems. VI. Influence of cardiac and pulmonary vascular lesions in the rat. | Three propellants were selected for investigation in rats because of their non-uniform effect in mice and monkeys. Trichlorofluoromethane (FC 11) provoked arrhythmia in all three animal species, dichlorodifluoromethane (FC 12) in monkeys and rats but not in mice, and difluoroethane (FC 152a) only in rats. In rats the a... | ['Adrenal Glands', 'Adrenalectomy', 'Adrenergic beta-Antagonists', 'Aerosol Propellants', 'Aerosols', 'Animals', 'Arrhythmias, Cardiac', 'Dose-Response Relationship, Drug', 'Electrocardiography', 'Female', 'Heart', 'Heart Rate', 'Hydrocarbons, Fluorinated', 'Isoproterenol', 'Lung', 'Necrosis', 'Propranolol', 'Pulmonary... | 235,808 | [['A06.300.071'], ['E04.270.115'], ['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['D26.255.165.055.055'], ['D20.280.055', 'D26.255.165.055'], ['B01.050'], ['C14.280.067', 'C23.550.073'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.370.380.240', 'E01.370.405.240'], ['A07.541'], ['E01.370.600.875.... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Airborne endotoxin in different background environments and seasons. | Endotoxin is a cell wall component from Gram-negative bacteria, and inhaled endotoxin contributes significantly to the induction of airway inflammation and dysfunction. Background levels of endotoxin have not yet been extensively described. In this study, airborne endotoxin was measured with a standardized protocol in ... | ['Agriculture', 'Air Pollutants', 'Denmark', 'Endotoxins', 'Environmental Exposure', 'Environmental Monitoring', 'Humans', 'Occupational Diseases', 'Occupational Exposure', 'Occupational Health', 'Reference Standards', 'Reference Values', 'Respiratory Tract Diseases', 'Seasons'] | 16,841,877 | [['J01.040'], ['D27.888.284.101'], ['Z01.542.816.124'], ['D23.946.123.329'], ['N06.850.460.350'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C24'], ['N06.850.460.350.600'], ['N01.400.525'], ['E05.978.808'], ['E05.978.810'], ['C08'], ['G01.910.645.661', 'G16.500.275.07... | ['Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Electrotonic current spread in colonic smooth muscle. | Current-induced changes in the membrane potential (electrotonic potentials) were measured intracellularly. The electrotonic potentials were seen to decay exponentially over many cells, suggesting electrotonic current spread. The characteristics of the electrotonic current spread were used to determine passive membrane ... | ['Animals', 'Colon', 'Dogs', 'Electrophysiology', 'Evoked Potentials', 'Humans', 'Membrane Potentials', 'Muscle, Smooth', 'Reference Values'] | 3,364,570 | [['B01.050'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['B01.050.150.900.649.313.750.250.216.200'], ['H01.158.344.528', 'H01.158.782.236'], ['G07.265.216.500', 'G11.561.200.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['A02.633.570', 'A10.690.4... | ['Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Commonly asked clinical questions about methadone maintenance. | Clinical questions about methadone maintenance are posed and answered. The areas include eligibility, size of clinic, number of patients, optimal maintenance dose, special populations, side effects, services, schedules, and the involvement of others. | ['Age Factors', 'Antidepressive Agents', 'Community Mental Health Services', 'Comprehensive Health Care', 'Facility Design and Construction', 'Female', 'Health Facility Size', 'Heroin Dependence', 'Humans', 'Methadone', 'Pregnancy', 'Pregnancy Complications', 'Private Practice', 'Time Factors'] | 563,384 | [['N05.715.350.075', 'N06.850.490.250'], ['D27.505.954.427.700.122'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['N04.590.233'], ['J01.086.339', 'N02.278.200'], ['N02.278.306', 'N05.300.430.410'], ['C25.775.643.500.400', 'F03.900.647.500.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.522.675... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
ARF and PITP restore GTP gamma S-stimulated protein secretion from cytosol-depleted HL60 cells by promoting PIP2 synthesis. | BACKGROUND: In many cell types, including neutrophils and HL60 cells, there is an absolute requirement for a GTP-dependent step to elicit Ca(2+)-regulated secretion. Neutrophils and HL60 cells secrete lysosomal enzymes from azurophilic granules; this secretion is inhibited by 1% ethanol, indicating that phosphatidate (... | ['ADP-Ribosylation Factor 1', 'ADP-Ribosylation Factors', 'Animals', 'Calcium', 'Carrier Proteins', 'Cytosol', 'GTP-Binding Proteins', "Guanosine 5'-O-(3-Thiotriphosphate)", 'HL-60 Cells', 'Humans', 'Membrane Proteins', 'Phosphatidylinositol 4,5-Diphosphate', 'Phospholipid Transfer Proteins', 'Recombinant Fusion Protei... | 8,793,299 | [['D08.811.277.040.330.300.400.100.100', 'D12.644.360.525.100.100', 'D12.776.157.325.515.100.100', 'D12.776.476.525.100.100', 'D12.776.543.990.300.150'], ['D08.811.277.040.330.300.400.100', 'D12.644.360.525.100', 'D12.776.157.325.515.100', 'D12.776.476.525.100'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interventional Radiology in Canada: Current Challenges and Future Directions. | OBJECTIVE: We aim to define the practice of interventional radiology (IR) in Canada, barriers that have been faced by interventional radiologists, and ways in which the Canadian Interventional Radiology Association (CIRA) have attempted to address these issues.CONCLUSION: IR has faced significant challenges in the Cana... | ['Canada', 'Career Choice', 'Forecasting', 'Humans', "Practice Patterns, Physicians'", 'Radiology, Interventional', 'Referral and Consultation', 'Societies, Medical'] | 29,975,118 | [['Z01.107.567.176'], ['F02.463.785.373.346.400'], ['I01.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.374.577', 'N05.300.625'], ['H02.403.740.675'], ['N04.452.758.849'], ['N03.540.828.589']] | ['Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Diabetes healthcare strategies. | This article describes and contrasts two approaches to planning strategies for diabetes care. These are the 'epidemiologically based healthcare needs assessment' and 'marginal analysis'. Both have their advantages and disadvantages. The most effective way of planning services is likely to be a pragmatic combination of ... | ['Delivery of Health Care', 'Diabetes Mellitus', 'Epidemiologic Methods', 'Evidence-Based Medicine', 'Health Services Needs and Demand', 'Humans', 'Patient Care Planning'] | 11,580,962 | [['N04.590.374', 'N05.300'], ['C18.452.394.750', 'C19.246'], ['E05.318', 'N06.850.520'], ['H02.249.750', 'H02.403.200.400'], ['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.233.624']] | ['Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Fibronectin in rheumatoid and non-rheumatoid arthritic synovial fluids and in synovial fluid cryoproteins. | Concentrations of fibronectin, immunoglobulins G, M, and A, and C3 and C4 components of complement, and other plasma proteins were determined in synovial fluids from patients with rheumatoid arthritis (RA) and other diseases (non-RA). Fibronectin concentrations were two to three times greater in all synovial fluids tha... | ['Arthritis', 'Arthritis, Rheumatoid', 'Complement C3', 'Complement C4', 'Fibrinogen', 'Fibronectins', 'Humans', 'Immunoglobulins', 'Synovial Fluid', 'Transferrin'] | 7,092,168 | [['C05.550.114'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D12.776.124.050.140', 'D12.776.124.486.274.250'], ['D12.776.124.486.274.350'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350',... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Blood glucose monitor: an alternative off-line method to measure glucose concentration during fermentations with Trichoderma reesei. | Two home, blood-glucose monitoring meters, OneTouch Ultra and Ascensia Contour, were used to determine the glucose concentration during fermentations of Trichoderma reesei in both flasks and bioreactors. The results, when compared to those given by the 3,5-dinitrosalicylic acid reducing sugar assay, HPLC and YSI 2700 S... | ['Biomass', 'Bioreactors', 'Blood Glucose Self-Monitoring', 'Fermentation', 'Glucose', 'Hydrogen-Ion Concentration', 'Regression Analysis', 'Solutions', 'Trichoderma'] | 17,377,750 | [['G16.500.275.157.100', 'N06.230.124.100'], ['E07.115', 'J01.897.120.115'], ['E01.370.225.124.100.105', 'E01.370.374.100', 'E01.370.520.100', 'E02.900.950.500', 'E05.200.124.100.105'], ['G02.111.158.249', 'G03.191.249'], ['D09.947.875.359.448'], ['G02.300'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Widespread disruption of genomic imprinting in adult interspecies mouse (Mus) hybrids. | Mammalian interspecies hybrids exhibit parent-of-origin effects in that offspring of reciprocal matings, even though genetically identical, frequently exhibit opposite phenotypes, especially in growth. This was also observed in hybridization with the genus Mus. These parent-of-origin effects suggested that imbalance in... | ['Animals', 'Chimera', 'DNA Methylation', 'Epigenesis, Genetic', 'Genomic Imprinting', 'Growth', 'Hybridization, Genetic', 'Mice', 'Mice, Congenic', 'Mice, Inbred C3H', 'Mice, Inbred C57BL'] | 16,145,677 | [['B01.050'], ['B05.200'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['G05.308.203'], ['G05.308.203.500'], ['G07.345.249'], ['E05.820.150.390', 'G05.090.390'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.040.500', 'B01.050.150.900.649.313.992.635.505.500.150'], ['B01.0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genotoxicity of anti-tumor necrosis factor therapy in patients with juvenile idiopathic arthritis. | OBJECTIVE: To assess the possible effects of both inflammation and the anti-tumor necrosis factor agents (anti-TNF) on DNA damage with a specific assay, and their effects on the repair capacity of DNA.METHODS: From a group of 20 children with juvenile idiopathic arthritis (JIA), 16 patients who completed the study and ... | ['Adolescent', 'Antirheumatic Agents', 'Arthritis, Juvenile', 'Child', 'Child, Preschool', 'Comet Assay', 'DNA Damage', 'DNA Repair', 'Female', 'Humans', 'Male', 'Methotrexate', 'Tumor Necrosis Factor-alpha'] | 20,191,493 | [['M01.060.057'], ['D27.505.954.329'], ['C05.550.114.122', 'C05.799.056', 'C17.300.775.049', 'C20.111.198'], ['M01.060.406'], ['M01.060.406.448'], ['E05.196.401.153.150', 'E05.301.300.100.150', 'E05.393.560.150', 'E05.940.560.150'], ['G05.200'], ['G02.111.222', 'G05.219'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Correlates of Disability in Asian Patients With Major Depressive Disorder. | PURPOSE: To examine correlates of disability in Asian patients with major depressive disorder (MDD).DESIGN AND METHODS: Participants were outpatients with DSM-IV MDD. Global disability and three disability domains (i.e., work/school, social life/leisure, and family/home life) were key outcomes. Several socio-demographi... | ['Adult', 'Asian Continental Ancestry Group', 'Cross-Sectional Studies', 'Depressive Disorder, Major', 'Diagnostic and Statistical Manual of Mental Disorders', 'Disability Evaluation', 'Disabled Persons', 'Female', 'Humans', 'Linear Models', 'Male', 'Middle Aged', 'Outpatients', 'Psychiatric Status Rating Scales', 'Qua... | 26,031,315 | [['M01.060.116'], ['M01.686.508.200'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F03.600.300.375'], ['L01.453.245.945.200'], ['E01.370.400'], ['M01.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.36... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Congenital Chopart amputation. A functional assessment. | Of 11 patients with congenital Chopart-level foot amputations, the average age was 6.75 years. Data collected from each patient included leg-length and calf-circumference measurements, range of motion at the ankle and subtalar joints, and a record of stump appearance. The patients were timed running a 50-m dash and mea... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Foot Deformities, Congenital', 'Gait', 'Humans', 'Infant', 'Leg Length Inequality', 'Male', 'Orthotic Devices', 'Prostheses and Implants', 'Radiography', 'Shoes', 'Tarsal Joints'] | 2,364,603 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C05.330.495', 'C05.660.585.512.380', 'C16.131.621.585.512.500'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C05.116.099.655', 'C23.300.808'], ['E07.858.442.743'], ['E07.695'], ['E01.370.350... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Preserving hesperetin nanosuspensions for dermal application. | Nanosuspensions as aqueous formulations need to be preserved. However, preservatives could vitiate the physical stability of suspensions and to a greater extent nanosuspensions. The impact of six varied preservatives on the physical stability of previously prepared nanosuspensions was studied. The hesperetin nanosuspen... | ['Administration, Topical', 'Drug Stability', 'Drug Storage', 'Electrochemistry', 'Hesperidin', 'Lasers', 'Light', 'Nanoparticles', 'Particle Size', 'Preservatives, Pharmaceutical', 'Scattering, Radiation', 'Skin Absorption', 'Suspensions', 'Temperature'] | 20,225,649 | [['E02.319.267.120'], ['E05.916.330'], ['E05.916.350'], ['H01.181.529.307'], ['D03.383.663.283.266.450.252.500', 'D03.633.100.150.266.450.252.500', 'D09.408.386'], ['E07.632.490', 'E07.710.520'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['J01.637.512.600'], ['G02.712'], ['D26.650.70... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Participation and enjoyment of leisure activities in school-aged children with cerebral palsy. | The objective of this study was to characterize participation in leisure activities in children with cerebral palsy (CP) and identify determinants of greater involvement. Ninety-five children of school age (9y 7mo [SD 2y 1mo]) with CP were recruited, and participation was evaluated with the Children's Assessment of Par... | ['Activities of Daily Living', 'Cerebral Palsy', 'Child', 'Cost of Illness', 'Disability Evaluation', 'Disabled Children', 'Female', 'Health Status Indicators', 'Humans', 'Leisure Activities', 'Male', 'Motor Skills', 'Severity of Illness Index', 'Statistics, Nonparametric'] | 18,834,388 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['C10.228.140.140.254'], ['M01.060.406'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['E01.370.400'], ['M01.150.200'], ['E05.318.308.980.438.475', 'N05.715.360.300.800.438.375', 'N06.850.520.308.98... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Development and validation of stability-indicating HPLC and UPLC methods for the determination of bicalutamide. | Six new process related impurities (Imp-08, Imp-09, Imp-10, Imp-12, Imp-13 and Imp-14) of bicalutamide (BCT) have been reported in this paper. BCT was subjected to oxidative, acid, alkaline, hydrolytic, thermal and photolytic degradation conditions and found to degrade in alkaline condition, yielding Imp-11. Stability-... | ['Anilides', 'Chromatography, High Pressure Liquid', 'Drug Contamination', 'Drug Stability', 'Least-Squares Analysis', 'Nitriles', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Tosyl Compounds'] | 22,407,342 | [['D02.065.199', 'D02.092.146.113'], ['E05.196.181.400.300'], ['N06.850.360'], ['E05.916.330'], ['E05.318.740.750.400', 'N05.715.360.750.695.440', 'N06.850.520.830.750.400'], ['D02.626'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', ... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Simultaneous removal of inorganic and organic compounds in wastewater by freshwater green microalgae. | Batch experiments were carried out for 7 days to investigate the simultaneous removal of various organic and inorganic contaminants including total nitrogen (TN), total phosphorus (TP), metals, pharmaceuticals and personal care products (PPCPs), endocrine disrupting chemicals (EDCs), and estrogenic activity in wastewat... | ['Biodegradation, Environmental', 'Endocrine Disruptors', 'Metals', 'Microalgae', 'Nitrogen', 'Organic Chemicals', 'Phosphorus', 'Waste Disposal, Fluid', 'Waste Water', 'Water Pollutants, Chemical', 'Water Purification'] | 24,953,257 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['D27.505.696.353', 'D27.888.141'], ['D01.552'], ['B05.080.500.600.500'], ['D01.268.604', 'D01.362.625'], ['D02'], ['D01.268.666'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['D20.944.932', 'N06.850.460.710.865'], ['D27.888.284.903.655'], ['N06.850.... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Persuading physicians to test their patients' level of kidney functioning: the effects of message frame and point of view. | A two-part field experiment was conducted to determine the effects of message frame (gain vs. loss) and point of view (personal vs. impersonal) on physicians' intentions and behavior to test their patients' level of kidney functioning. One hundred and fifty-one physicians returned a survey that accompanied one of four ... | ['Adult', 'Female', 'Health Promotion', 'Humans', 'Intention', 'Kidney Failure, Chronic', 'Kidney Function Tests', 'Male', 'Mass Screening', 'Middle Aged', 'Persuasive Communication', 'Physician-Patient Relations', 'Physicians, Family', "Practice Patterns, Physicians'"] | 20,390,677 | [['M01.060.116'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658.650', 'F02.463.306'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['E01.370.390.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500',... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Giving ourselves: the ethics of anatomical donation. | In some European countries, such as Italy, medical education is threatened by a dearth of anatomical specimens. Such a shortage could spread to other nations, including the United States. This article addresses two ethical questions in body donation. Why might people choose to donate their bodies to education and scien... | ['Altruism', 'Anatomy', 'Attitude to Health', 'Cadaver', 'Dissection', 'Education, Medical', 'Ethics', 'Gift Giving', 'Humans', 'Italy', 'Models, Psychological', 'Public Opinion', 'Teaching', 'United States'] | 19,177,414 | [['F01.145.813.090'], ['H01.158.100'], ['F01.100.150', 'N05.300.150'], ['C23.550.260.224'], ['E01.370.225.998.221', 'E04.221', 'E05.200.998.221'], ['I02.358.399'], ['K01.752.566.479', 'N05.350'], ['F01.145.813.208'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['E05.599.695'], ['I01.880.630.548'],... | ['Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Risk Factors Associated With Reintervention After Thoracic Endovascular Aortic Repair for Descending Aortic Pathologies. | BACKGROUND:: Thoracic endovascular aortic repair (TEVAR) is associated with several short-term benefits, including reduced morbidity and mortality; however, the long-term durability of TEVAR and the need for secondary aortic reintervention remain unclear. We aimed to determine the adverse outcomes, including aortic rei... | ['Aged', 'Aneurysm, Dissecting', 'Aortic Aneurysm, Thoracic', 'Aortography', 'Blood Vessel Prosthesis Implantation', 'Computed Tomography Angiography', 'Endoleak', 'Endovascular Procedures', 'Female', 'Hemoptysis', 'Humans', 'Male', 'Middle Aged', 'Peripheral Arterial Disease', 'Reoperation', 'Republic of Korea', 'Retr... | 30,866,751 | [['M01.060.116.100'], ['C14.907.055.050'], ['C14.907.055.239.125', 'C14.907.109.139.125'], ['E01.370.350.700.060.070', 'E01.370.370.050.070'], ['E04.100.814.868.500', 'E04.650.200'], ['E01.370.350.350.810.335', 'E01.370.350.567.250', 'E01.370.350.600.350.700.810.335', 'E01.370.350.700.700.810.335', 'E01.370.350.700.810... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Towards performance measurement in reconstructive surgery: a multicentre pilot study of free and pedicled flap procedures. | OBJECTIVES: To pilot the acceptability and feasibility of clinical audit in free and pedicled flap reconstruction. To establish a baseline flap failure rate in participating units, so that a sample size calculation could be performed for future national audit.METHODS: A proforma was piloted over a 3-month period in fou... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Feasibility Studies', 'Female', 'Graft Survival', 'Humans', 'Length of Stay', 'Male', 'Medical Audit', 'Middle Aged', 'Pilot Projects', 'Prospective Studies', 'Risk Factors', 'Surgical Flaps'] | 16,673,538 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['N04.761.700.250.500', 'N... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Four diastereoisomers of cyclo(-Asp-Val-): inconsistency of their properties with the proposed structure of cairomycin A. | The four diastereoisomers of cyclo(-Asp-Val-) were synthesized to compare with a proposed structure of cairomycin A. Their antimicrobial activities were determined against both Gram-positive and Gram-negative bacteria. The physico-chemical properties of the isomers were characterized by mp, 1H NMR, IR, FAB-MS, and solu... | ['Anti-Bacterial Agents', 'Antimicrobial Cationic Peptides', 'Peptides', 'Peptides, Cyclic', 'Stereoisomerism', 'Structure-Activity Relationship'] | 1,556,015 | [['D27.505.954.122.085'], ['D12.644.050', 'D12.776.543.695.054'], ['D12.644'], ['D04.345.566', 'D12.644.641'], ['G02.607.445.682'], ['G02.111.830', 'G07.690.773.997']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Role of psychosocial variables in the metabolic control of type 2 diabetics]. | BACKGROUND: Patients' cultural orientations play an important role in chronic diseases. However, medical education research still does not emphasize these variables.AIM: To measure the influence of psychosocial dimensions on blood glucose control in type 2 diabetic patients.SUBJECTS AND METHODS: Case-control design. Da... | ['Adult', 'Aged', 'Blood Glucose', 'Case-Control Studies', 'Chile', 'Cultural Characteristics', 'Diabetes Mellitus, Type 2', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Psychology, Social', 'Random Allocation', 'Risk Factors', 'Socioeconomic Factors'] | 18,949,184 | [['M01.060.116'], ['M01.060.116.100'], ['D09.947.875.359.448.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['Z01.107.757.235'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['C18.452.394.750.149', 'C19.246.300'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Cost of Operating Central Cancer Registries and Factors That Affect Cost: Findings From an Economic Evaluation of Centers for Disease Control and Prevention National Program of Cancer Registries. | CONTEXT: The Centers for Disease Control and Prevention (CDC) evaluated the economics of the National Program of Cancer Registries to provide the CDC, the registries, and policy makers with the economics evidence-base to make optimal decisions about resource allocation. Cancer registry budgets are under increasing thre... | ['Centers for Disease Control and Prevention, U.S.', 'Cost-Benefit Analysis', 'Data Collection', 'Healthcare Financing', 'Humans', 'Neoplasms', 'Program Development', 'Registries', 'Regression Analysis', 'Resource Allocation', 'United States'] | 26,642,226 | [['I01.409.418.750.600.650.200', 'N03.540.348.500.500.600.650.225'], ['N03.219.151.125'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['N03.219.483.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['N04.452.760'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.360.300.715.700'... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
MNF1, a leaf tissue-specific DNA-binding protein of maize, interacts with the cauliflower mosaic virus 35S promoter as well as the C4 photosynthetic phosphoenolpyruvate carboxylase gene promoter. | When gel shift assays were performed with maize nuclear extract and a DNA fragment containing the cauliflower mosaic virus (CaMV) 35S promoter, three DNA-protein complexes were observed. Analyses with nuclear extracts prepared from green leaves, etiolated leaves, stems and roots showed that the complexes resulted from ... | ['Base Sequence', 'Binding, Competitive', 'DNA', 'DNA-Binding Proteins', 'Molecular Sequence Data', 'Mosaic Viruses', 'Organ Specificity', 'Phosphoenolpyruvate Carboxylase', 'Plant Proteins', 'Plants, Toxic', 'Promoter Regions, Genetic', 'Tobacco', 'Zea mays'] | 1,627,769 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D13.444.308'], ['D12.776.260'], ['L01.453.245.667'], ['B04.715.464'], ['G07.650'], ['D08.811.520.224.125.650'], ['D12.776.765'], ['B01.650.660'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Customized mandibular reconstruction plates improve mechanical performance in a mandibular reconstruction model. | The purpose of this paper was to analyze the biomechanical performance of customized mandibular reconstruction plates with optimized strength. The best locations for increasing bar widths were determined with a sensitivity analysis. Standard and customized plates were mounted on mandible models and mechanically tested.... | ['Biomechanical Phenomena', 'Bone Plates', 'Finite Element Analysis', 'Humans', 'Mandible', 'Mandibular Reconstruction', 'Stress, Mechanical'] | 27,887,036 | [['G01.154.090', 'G01.374.089'], ['E07.695.370.374', 'E07.858.442.660.460.374', 'E07.858.690.725.460.374'], ['E05.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['E06.645.562.500'], ['G01.374.835']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter. | Mitochondrial Ca(2+) uptake via the uniporter is central to cell metabolism, signaling, and survival. Recent studies identified MCU as the uniporter's likely pore and MICU1, an EF-hand protein, as its critical regulator. How this complex decodes dynamic cytoplasmic [Ca(2+)] ([Ca(2+)]c) signals, to tune out small [Ca(2+... | ['Animals', 'Calcium Channels', 'Calcium Signaling', 'Calcium-Binding Proteins', 'Cation Transport Proteins', 'Cells, Cultured', 'HEK293 Cells', 'HeLa Cells', 'Hepatocytes', 'Humans', 'Mice', 'Mitochondria', 'Mitochondrial Membrane Transport Proteins', 'Mitochondrial Membranes', 'RNA Interference', 'RNA, Small Interfer... | 23,747,253 | [['B01.050'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['D12.776.157.125'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'], ['A11.251'], ['A11.251.210.172.750', 'A11.436.334'], ['A11.251.210.190.400', 'A11.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Current distribution and characterization of the wild grapevine populations in Andalusia (Spain). | For decades, human activities have gradually destroyed the natural habitats of wild grapevine, Vitis vinifera L. subsp. sylvestris (Gmelin) Hegi, and nowadays this species is endangered in southern Europe. In this paper, 94 populations of this species have been localized and characterized in the Andalusian region in th... | ['Ecology', 'Microsatellite Repeats', 'Spain', 'Vitis'] | 28,256,414 | [['H01.158.273.248', 'H01.277.249'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['Z01.542.846'], ['B01.650.940.800.575.912.250.965.500']] | ['Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
The fate and behavior of mercury in coal-fired power plants. | For the past 22 years in the Netherlands, the behavior of Hg in coal-fired power plants has been studied extensively. Coal from all over the world is fired in Dutch power stations. First, the Hg concentrations in these coals were measured. Second, the fate of the Hg during combustion was established by performing mass ... | ['Air Pollutants', 'Coal', 'Environmental Monitoring', 'Incineration', 'Mercury', 'Netherlands', 'Power Plants'] | 12,184,689 | [['D27.888.284.101'], ['D20.345.108', 'N06.230.132.258.108'], ['N06.850.460.350.080', 'N06.850.780.375'], ['N06.850.860.510.900.600.500'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['Z01.542.651'], ['J01.780', 'J03.540.680']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Light diffusion in photosensitive epilepsy. | Photosensitivity is usually tested by intermittent photic stimulation. Photoparoxysmal responses in the EEG are enhanced when the eyes remain closed during stimulation. We tested the hypothesis that this is due to diffusion of light by the eyelids. In 25 photosensitive patients, conditions 'eye closure', 'eyes closed',... | ['Adolescent', 'Adult', 'Child', 'Electroencephalography', 'Epilepsy', 'Eye', 'Eyelids', 'Female', 'Humans', 'Male', 'Photic Stimulation', 'Scattering, Radiation'] | 9,680,149 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490'], ['A01.456.505.420', 'A09.371'], ['A01.456.505.420.504', 'A09.371.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.723.729'], ['E05.196.822', 'G01.867']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Microsecond folding dynamics of apomyoglobin at acidic pH. | Apomyolgobin (apoMb) is an important model for understanding the folding mechanism of helical proteins. This study focuses on a partially structured state of sperm whale apoMb populated at pH 4.2 (M-state), which structurally resembles a late kinetic intermediate in the formation of the native state (N) at higher pH. T... | ['Apoproteins', 'Hydrogen-Ion Concentration', 'Kinetics', 'Models, Molecular', 'Myoglobin', 'Protein Folding', 'Thermodynamics', 'Time Factors'] | 22,475,221 | [['D12.776.070'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['E05.599.595'], ['D12.776.210.500.588', 'D12.776.422.316.940'], ['G01.154.651', 'G02.111.688'], ['G01.906'], ['G01.910.857']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors Associated with Immunological Discordance in HIV-Infected Patients Receiving Antiretroviral Therapy with Complete Viral Suppression in a Resource-Limited Setting. | "Immunological discordance," i.e., immunological failure despite complete viral suppression in human immunodeficiency virus (HIV)-infected patients receiving antiretroviral therapy (ART), is associated with increased risk of AIDS or death. To evaluate risk factors for immunological discordance in a resource-limited set... | ['Adult', 'Anti-Retroviral Agents', 'Antiretroviral Therapy, Highly Active', 'CD4 Lymphocyte Count', 'Case-Control Studies', 'Female', 'HIV', 'HIV Infections', 'Humans', 'Male', 'Middle Aged', 'RNA, Viral', 'Risk Factors'] | 25,720,640 | [['M01.060.116'], ['D27.505.954.122.388.077'], ['E02.319.310.075'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.500.150'], ['E05.318.372.500.500', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Treatment Patterns and Health Resource Utilization Among Patients Diagnosed With Early Stage Resected Non-Small Cell Lung Cancer at US Community Oncology Practices. | UNLABELLED: Data on adjuvant therapy in resected non-small cell lung cancer (NSCLC) in routine practice are lacking in the United States. This retrospective observational database study included 609 community oncology patients with resected stage IB to IIIA NSCLC. Use of adjuvant therapy was 39.1% at disease stage IB a... | ['Antineoplastic Combined Chemotherapy Protocols', 'Carboplatin', 'Carcinoma, Non-Small-Cell Lung', 'Chemotherapy, Adjuvant', 'Cisplatin', 'Combined Modality Therapy', 'Community Health Centers', 'Costs and Cost Analysis', 'Electronic Health Records', 'Health Resources', 'Humans', 'Lung Neoplasms', 'Neoplasm Staging', ... | 25,681,298 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D02.257.125'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['E02.186.170', 'E02.319.170'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E02.186'], ['N02.278.035.128'], ['N03.219.151'], ['E05.318.308.940.968.625.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Age-related dysfunction in mechanotransduction impairs differentiation of human mammary epithelial progenitors. | Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during human mammary epithelial aging for reasons not understood. Multipotent progenitors from women aged <30 years were exposed to a physiologically relevant range of matrix elastic modulus (stiffness). Increased stiffness causes... | ['Adaptor Proteins, Signal Transducing', 'Adult', 'Age Factors', 'Cell Differentiation', 'Epithelial Cells', 'Female', 'Humans', 'Mammary Glands, Human', 'Mechanotransduction, Cellular', 'Middle Aged', 'Phosphoproteins', 'Stem Cells', 'Transcription Factors'] | 24,910,432 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['G04.152'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.236.249', 'A10.336.532'], ['G01.154.090.500', 'G02.111.820.580', 'G04.835.580'], ['M01.060.116.630'], ['D12.776.744'], ['A... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A contextual coding system for transplantation and end stage diseases. | The Establissement fran?ais des Greffes (EfG) is a state agency dealing with Public Health issues related to organ, tissue and cell transplantation in France. EfG maintains a national information system (EfG-IS) for the evaluation of organ transplantation activities. The EfG-IS is moving toward a new n-tier architectur... | ['Cell Transplantation', 'Computer Systems', 'Forms and Records Control', 'France', 'Government Agencies', 'Humans', 'Information Systems', 'Terminally Ill', 'Tissue Transplantation', 'Transplantation'] | 14,664,029 | [['E02.095.147.500', 'E04.936.225'], ['L01.224.230'], ['N04.452.758.708.200.400'], ['Z01.542.286'], ['I01.409.418', 'N03.540.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.313.500.750.300'], ['M01.873'], ['E02.095.147.725', 'E04.936.580'], ['E04.936']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Protein intrinsic disorder within the Potyvirus genus: from proteome-wide analysis to functional annotation. | Within proteins, intrinsically disordered regions (IDRs) are devoid of stable secondary and tertiary structures under physiological conditions and rather exist as dynamic ensembles of inter-converting conformers. Although ubiquitous in all domains of life, the intrinsic disorder content is highly variable in viral geno... | ['Intrinsically Disordered Proteins', 'Models, Molecular', 'Molecular Sequence Annotation', 'Phylogeny', 'Potyvirus', 'Protein Processing, Post-Translational', 'Protein Structure, Tertiary', 'Proteolysis', 'Proteome', 'Sequence Analysis, Protein', 'Viral Proteins'] | 26,699,268 | [['D12.776.481'], ['E05.599.595'], ['E05.393.760.479', 'L01.453.245.667.580'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B04.715.464.600', 'B04.715.635.600', 'B04.820.578.782.600'], ['G02.111.660.871.790.600', 'G02.111.691.600', 'G03.734.871.790.600', 'G05.308.670.600'], ['G02.111.570.820.709.610'], ['G02.111.720', ... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The reliability of midstream urine culture from circumcised male infants. | The reliability of midstream urine culture from circumcised male infants was studied in 60 infants aged 1 to 21 weeks. A midstream urine specimen was collected after cleansing the penis. When the bladder was full again, a suprapubic bladder aspiration (SPA) was also performed. The results of the urine cultures were alm... | ['Circumcision, Male', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Prospective Studies', 'Reproducibility of Results', 'Specimen Handling', 'Suction', 'Urine'] | 8,362,814 | [['E02.218.085.170', 'E04.085.170', 'E04.950.774.860.226'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Acute changes in cardiovascular function during the onset period of daytime sleep: comparison to lying awake and standing. | The siesta habit is associated with a 37% reduction in coronary mortality, possibly because of reduced cardiovascular stress associated with daytime sleep. Whether the most important behavior is the daytime nap itself, a supine posture, or the expectancy of a nap is unknown. We present the first detailed description on... | ['Adult', 'Blood Pressure', 'Female', 'Heart Rate', 'Hemodynamics', 'Humans', 'Male', 'Photoperiod', 'Polysomnography', 'Posture', 'Rest', 'Sleep', 'Sleep Deprivation', 'Time Factors'] | 17,641,220 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.875.500', 'G09.330.380.500'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.910.675'], ['E01.370.520.625'], ['G11.427.695'], ['I03.450.769.647'], ['F02.830.855', 'G11.561.803'], ['C10.886.425.175', 'C23.888.592.796.772... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
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