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[Interactions between patients and physicians: why should we care about gender issues?]. | This article presents the major findings of research on medical interactions from a gender perspective. Male and female physicians give the same amount of medical informations to their patients, but male physicians discuss less the psychosocial aspects of the illness. Male physicians ask less medical and psychosocial q... | ['Female', 'Humans', 'Male', 'Physician-Patient Relations', 'Physicians', 'Sex Factors'] | 20,806,560 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.650.675', 'N05.300.660.625'], ['M01.526.485.810', 'N02.360.810'], ['N05.715.350.675', 'N06.850.490.875']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Relationships between the presence of anti-Tat antibody, DNA and RNA viral load. | The possible relationships between the intensity of humoral response to full length Tat protein, the amount of proviral DNA reservoir in peripheral blood mononuclear cells and RNA viral load were analyzed in plasma samples obtained from a group of HIV-1 seropositive subjects, who never received any antiretroviral thera... | ['Adult', 'DNA, Viral', 'Female', 'Gene Products, tat', 'HIV Antibodies', 'HIV Seropositivity', 'HIV-1', 'Humans', 'Immunoenzyme Techniques', 'Immunoglobulin G', 'Male', 'RNA, Viral', 'Viral Load', 'tat Gene Products, Human Immunodeficiency Virus'] | 11,497,076 | [['M01.060.116'], ['D13.444.308.568'], ['D12.776.260.755.199', 'D12.776.930.900.199', 'D12.776.964.900.750.750', 'D12.776.964.925.984.400'], ['D12.776.124.486.485.114.254.150.440', 'D12.776.124.790.651.114.254.150.440', 'D12.776.377.715.548.114.254.150.440'], ['C01.221.250.875.500', 'C01.221.812.640.400.500', 'C01.778.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Secondary abdominal compartment syndrome is an elusive early complication of traumatic shock resuscitation. | BACKGROUND: The term secondary abdominal compartment syndrome (ACS) has been applied to describe trauma patients who develop ACS but do not have abdominal injuries. The purpose of this study was to describe major trauma victims who developed secondary ACS during standardized shock resuscitation.METHODS: Our prospective... | ['Abdominal Injuries', 'Adult', 'Compartment Syndromes', 'Decompression, Surgical', 'Female', 'Fluid Therapy', 'Humans', 'Male', 'Middle Aged', 'Resuscitation', 'Retrospective Studies', 'Shock, Traumatic', 'Thoracic Injuries', 'Treatment Outcome'] | 12,488,160 | [['C26.017'], ['M01.060.116'], ['C05.651.180', 'C14.907.303'], ['E04.188'], ['E02.319.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.365.647'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.50... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Alterations in 32P-labelled intermediates during flux activation of human platelet glycolysis. | Using a newly developed isotopic tracer technique for the measurement of 32P-labelled intermediates in glycolysis and nucleotide metabolism in platelets, we studied the variations in 32P-labelled intermediates during activation of the glycolytic flux by cyanide and platelet-activating agents. The major variations occur... | ['Adenosine Diphosphate', 'Blood Platelets', 'Calcimycin', 'Collagen', 'Cyanides', 'Epinephrine', 'Fructosediphosphates', 'Glycolysis', 'Humans', 'Lactates', 'Lactic Acid', 'Phosphates', 'Thrombin'] | 6,437,451 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['A11.118.188', 'A15.145.229.188'], ['D03.633.100.221.173'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D01.248.497.158.291', 'D01.625.400.100'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats. | The present study investigated the effect of postischaemic infusion of an irreversible monoamine oxidase B (MAO-B) inhibitor, l-deprenyl, an equipotent dose of a reversible MAO-B inhibitor, lazabemide, or 0.9% NaCl on infarct volumes following focal cerebral ischaemia in rats. The drug doses (0.3 mg/kg) were selected t... | ['Animals', 'Brain', 'Brain Ischemia', 'Cerebral Infarction', 'Male', 'Monoamine Oxidase', 'Monoamine Oxidase Inhibitors', 'Neurons', 'Picolinic Acids', 'Rats', 'Rats, Wistar', 'Selegiline'] | 11,129,505 | [['B01.050'], ['A08.186.211'], ['C10.228.140.300.150', 'C14.907.253.092'], ['C10.228.140.300.150.477.200', 'C10.228.140.300.775.200.200', 'C14.907.253.092.477.200', 'C14.907.253.855.200.200', 'C23.550.513.355.250.200', 'C23.550.717.489.250.200'], ['D08.811.682.664.750'], ['D27.505.519.389.616'], ['A08.675', 'A11.671'],... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolated 'idiopathic' micropenis: hidden genetic defects? | Micropenis is defined as a stretched penile length of less than 2-2.5SD for age. Aetiologies include hypogonadotropic hypogonadism, testicular dysgenesis, defects in testosterone synthesis, androgen resistance [5á-reductase (5áR) deficiency or partial androgen insensitivity] and other rare causes like growth hormone GH... | ['Amino Acid Sequence', 'Child', 'Child, Preschool', 'Follicle Stimulating Hormone', 'Genital Diseases, Male', 'Humans', 'Karyotyping', 'Luteinizing Hormone', 'Male', 'Molecular Sequence Data', 'Mutation', 'Penis', 'Sequence Homology, Amino Acid', 'Steroidogenic Factor 1', 'Testosterone'] | 21,535,007 | [['G02.111.570.060', 'L01.453.245.667.060'], ['M01.060.406'], ['M01.060.406.448'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['C12.294'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315', 'E05.393.285.4... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Arginine vasotocin activates phosphoinositide signal transduction system and potentiates N-acetyltransferase activity in the rat pineal gland. | The pineal gland is innervated by pinealopetal peptidergic fibers originating in the hypothalamic nuclei which release arginine vasopressin (AVP) and arginine vasotocin (AVT) from their endings. Since the mechanism of AVT action on the pineal signal transduction and melatonin synthesis has not been determined so far, w... | ['Animals', 'Antidiuretic Hormone Receptor Antagonists', 'Arginine Vasopressin', 'Arylamine N-Acetyltransferase', 'Circadian Rhythm', 'Deamino Arginine Vasopressin', 'Male', 'Peptide Fragments', 'Phosphatidic Acids', 'Phosphatidylinositol Phosphates', 'Phosphatidylinositols', 'Pineal Gland', 'Propranolol', 'Rats', 'Rat... | 10,203,240 | [['B01.050'], ['D27.505.519.174', 'D27.505.696.560.311'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['D08.811.913.050.134.138'], ['G07.180.562.190'], ['D06.472.699.631.692.781.100.250', 'D12.644.400.900.100.250', 'D12.644.456... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association analysis of AKT1 and schizophrenia in a UK case control sample. | AKT1 (V-akt murine thyoma viral oncogene homolog 1) is involved in intracellular signalling pathways postulated as of aetiological importance in schizophrenia. Markers in the AKT1 gene have also recently been associated with schizophrenia in two samples of European origin and in Japanese and Iranian samples. Aiming to ... | ['Adult', 'Alleles', 'Case-Control Studies', 'Cross-Cultural Comparison', 'Female', 'Gene Expression', 'Gene Frequency', 'Genetic Markers', 'Genetic Predisposition to Disease', 'Genotype', 'Haplotypes', 'Humans', 'Ireland', 'Japan', 'Male', 'Middle Aged', 'Polymorphism, Single Nucleotide', 'Proto-Oncogene Proteins c-ak... | 17,383,860 | [['M01.060.116'], ['G05.360.340.024.340.030'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['G05.297'], ['G05.330'], ['D23.101.387', 'G05.695.450'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['G05.380.360'], ['B01.050.150.900.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Postoperative electromyographic function of tendon transfers in patients with cerebral palsy. | Electromyographic studies were performed on 13 patients with cerebral palsy before and after flexor carpi ulnaris transfers. No changes in activity of the extensor digit communis were noted in the transferred muscles. This further validates the rationale of pre-operative planning based on such studies. | ['Cerebral Palsy', 'Child', 'Electromyography', 'Hand Deformities, Acquired', 'Humans', 'Isometric Contraction', 'Motor Skills', 'Muscles', 'Postoperative Complications', 'Tendon Transfer'] | 2,227,142 | [['C10.228.140.140.254'], ['M01.060.406'], ['E01.370.405.255', 'E01.370.530.255'], ['C05.390.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494.472'], ['F02.808.260'], ['A02.633', 'A10.690'], ['C23.550.767'], ['E04.555.700']] | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Recommended antimicrobial treatment of uncomplicated gonorrhoea in 2009 in 11 East European countries: implementation of a Neisseria gonorrhoeae antimicrobial susceptibility programme in this region is crucial. | BACKGROUND: Antimicrobial resistance (AMR) in Neisseria gonorrhoeae (gonococcus) is a major problem worldwide. Quality-assured and quality-controlled AMR surveillance data on gonococci globally are crucial for public health purposes. In East European countries, knowledge regarding gonococcal AMR and its prevalence is l... | ['Anti-Bacterial Agents', 'Drug Resistance, Multiple, Bacterial', 'Europe, Eastern', 'Gonorrhea', 'Health Policy', 'Humans', 'Microbial Sensitivity Tests', 'Neisseria gonorrhoeae', 'Population Surveillance', 'Surveys and Questionnaires'] | 20,460,266 | [['D27.505.954.122.085'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['Z01.542.248'], ['C01.150.252.400.625.275', 'C01.150.252.734.401', 'C01.221.812.281.401', 'C01.778.281.401', 'C12.294.668.281.401', 'C13.351.500.711.281.401'], ['I01.655.500.608.400', 'I01.880.60... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States. | Tickborne rickettsial diseases continue to cause severe illness and death in otherwise healthy adults and children, despite the availability of low-cost, effective antibacterial therapy. Recognition early in the clinical course is critical because this is the period when antibacterial therapy is most effective. Early s... | ['Anaplasmosis', 'Anti-Bacterial Agents', 'Diagnosis, Differential', 'Doxycycline', 'Ehrlichiosis', 'Humans', 'Rickettsia Infections', 'Rocky Mountain Spotted Fever', 'Tick-Borne Diseases', 'United States'] | 27,172,113 | [['C01.150.252.400.054.500', 'C01.150.252.400.082', 'C01.920.930.163', 'C22.085'], ['D27.505.954.122.085'], ['E01.171'], ['D02.455.426.559.847.562.900.200', 'D04.615.562.900.200'], ['C01.150.252.400.054.750', 'C01.150.252.400.285', 'C01.920.930.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.150.252.400.7... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
In vivo processing of the precursor of the major exoglucanase by KEX2 endoprotease in the Saccharomyces cerevisiae secretory pathway. | We have established the main post-translational modification of the major exoglucanase of Saccharomyces cerevisiae as the enzyme progresses through the secretory pathway. The protein portion of the enzyme accumulated by sec18 cells was about 2 kDa larger than that of the secreted enzyme. This precursor (form A) was sta... | ['Adenosine Triphosphatases', 'Amino Acid Sequence', 'Biological Transport', 'Enzyme Precursors', 'Fungal Proteins', 'Glucan 1,3-beta-Glucosidase', 'Guanine Nucleotide Exchange Factors', 'Isoenzymes', 'Molecular Sequence Data', 'Mutation', 'Proprotein Convertases', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae ... | 9,244,183 | [['D08.811.277.040.025'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G03.143'], ['D08.622', 'D12.776.811.243'], ['D12.776.354'], ['D08.811.277.450.420.200.500'], ['D12.644.360.325.300', 'D12.776.476.325.300'], ['D08.811.348', 'D12.776.800.300'], ['L01.453.245.667'], ['G05.365.590'], ['D08.811.277.656.837'], ['B01.30... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Evaluation of pneumonia in children: comparison of MRI with fast imaging sequences at 1.5T with chest radiographs. | BACKGROUND: Although there has been a study aimed at magnetic resonance imaging (MRI) evaluation of pneumonia in children at a low magnetic field (0.2T), there is no study which assessed the efficacy of MRI, particularly with fast imaging sequences at 1.5T, for evaluating pneumonia in children.PURPOSE: To investigate t... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Magnetic Resonance Imaging', 'Male', 'Pneumonia', 'Prospective Studies', 'Radiography, Thoracic'] | 21,816,896 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.350.825.500'], ['C01.748.610', 'C08.381.677', 'C08.730.610'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.350.700.730']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Promoter for Sindbis virus RNA-dependent subgenomic RNA transcription. | Sindbis virus is a positive-strand RNA enveloped virus, a member of the Alphavirus genus of the Togaviridae family. Two species of mRNA are synthesized in cells infected with Sindbis virus; one, the 49S RNA, is the genomic RNA; the other, the 26S RNA, is a subgenomic RNA that is identical in sequence to the 3' one-thir... | ['Animals', 'Base Sequence', 'Cloning, Molecular', 'Molecular Sequence Data', 'Promoter Regions, Genetic', 'RNA, Viral', 'Sindbis Virus', 'Transcription, Genetic', 'Transfection'] | 2,319,651 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['L01.453.245.667'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D13.444.735.828'], ['B04.820.578.875.054.860'], ['G02.111.873', 'G05.297.700'], ['E05.393.350.810', 'G05.728.860']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Fulminant diphtheria myocarditis in an unvaccinated preschool child]. | We describe a case of a three year old unvaccinated child who developed a fulminant diphtheric myocarditis and nephritis four days after the onset of a tonsillar diphtheria. Despite of the administration of antitoxin on day three and four the child died within 48 hours from the beginning of rhythm disturbances. The car... | ['Child, Preschool', 'Corynebacterium diphtheriae', 'Critical Care', 'Diphtheria', 'Diphtheria Antitoxin', 'Electrocardiography', 'Fatal Outcome', 'Germany', 'Humans', 'Male', 'Myocarditis', 'Nephritis', 'Travel'] | 10,592,928 | [['M01.060.406.448'], ['B03.510.024.250.150', 'B03.510.460.400.400.200.150'], ['E02.760.190', 'N02.421.585.190'], ['C01.150.252.410.040.246.388'], ['D12.776.124.486.485.114.573.601.438', 'D12.776.124.790.651.114.573.601.438', 'D12.776.377.715.548.114.573.601.438', 'D20.215.401.601.388'], ['E01.370.370.380.240', 'E01.37... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Specificity of interaction of INI1/hSNF5 with retroviral integrases and its functional significance. | Integrase interactor 1 (INI1)/hSNF5 is a host factor that directly interacts with human immunodeficiency virus type 1 (HIV-1) integrase and is incorporated into HIV-1 virions. Here, we show that while INI1/hSNF5 is completely absent from purified microvesicular fractions, it is specifically incorporated into HIV-1 viri... | ['Binding Sites', 'Cell Line', 'Chromosomal Proteins, Non-Histone', 'DNA-Binding Proteins', 'HIV Integrase', 'HIV-1', 'Humans', 'Integrases', 'Mutation', 'Protein Binding', 'Retroviridae', 'SMARCB1 Protein', 'Substrate Specificity', 'Transcription Factors', 'Two-Hybrid System Techniques', 'Virion'] | 14,963,118 | [['G02.111.570.120'], ['A11.251.210'], ['D12.776.660.235', 'D12.776.664.235'], ['D12.776.260'], ['D08.811.739.500.667.500', 'D08.811.913.696.445.825.500', 'D12.776.964.775.375.545.500', 'D12.776.964.775.562.764.500', 'D12.776.964.900.750.500.545.500', 'D12.776.964.970.600.850.375.545.500'], ['B04.820.650.589.650.350.40... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of radiotherapy in renal involvement in acute childhood leukemia. | Twenty-one children with acute leukemia received irradiation to the renal area for the following reasons: hypertension (2 patients); oliguria (5 patients); mass-related symptoms (5 patients); and as an adjuvant to supportive medical management in preventing renal failure (9 patients). All but 2 patients exhibited bone ... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Hypertension, Renal', 'Infant', 'Kidney Diseases', 'Leukemia', 'Male', 'Neoplasm Metastasis', 'Oliguria'] | 1,188,120 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.331', 'C13.351.968.419.331', 'C14.907.489.631'], ['M01.060.703'], ['C12.777.419', 'C13.351.968.419'], ['C04.557.337'], ['C04.697.650', 'C23.550.727.650'], ['C12.777.934.600', 'C13.351.968.934.600', 'C2... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
New findings concerning early bone grafting procedures in patients with cleft lip and palate. | The following paper reports on our investigations of long-term results of 177 primary bone grafting procedures carried out in the period from 1959 to 1969. In an assessment of possible influential factors (multivariate statistical analysis), neither age at operation, dental hygiene, cleft form, aplasia or loss of teeth... | ['Bone Transplantation', 'Cleft Lip', 'Cleft Palate', 'Follow-Up Studies', 'Humans', 'Infant', 'Time Factors'] | 8,530,704 | [['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['C07.465.409.225', 'C07.465.525.164', 'C07.650.525.164', 'C16.131.850.525.164'], ['C05.500.460.185', 'C05.660.207.540.460.185', 'C07.320.440.185', 'C07.465.525.185', 'C07.650.500.460.185', 'C07.650.525.185', 'C16.131.621.207.540.460.185', 'C16.131.850.500.460... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. | Despite evidence that kinesin family member 14 (KIF14) can serve as a prognostic biomarker in various solid tumors, how it contributes to tumorigenesis remains unclear. We observed that experimental decrease in KIF14 expression increases docetaxel chemosensitivity in estrogen receptor-negative/progesterone receptor-neg... | ['BRCA1 Protein', 'Biomarkers, Tumor', 'Cell Proliferation', 'Drug Resistance, Neoplasm', 'Female', 'Gene Expression Regulation, Neoplastic', 'Gene Knockdown Techniques', 'Heterozygote', 'Humans', 'Kinesin', 'Neoadjuvant Therapy', 'Oncogene Proteins', 'Phosphorylation', 'Proto-Oncogene Proteins c-akt', 'Triple Negative... | 24,784,001 | [['D12.776.313.125', 'D12.776.624.776.100', 'D12.776.660.100', 'D12.776.744.100', 'D12.776.930.137'], ['D23.101.140'], ['G04.161.750', 'G07.345.249.410.750'], ['G07.690.773.984.395'], ['G05.308.370'], ['E05.393.335.500'], ['G05.380.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.040.025.193.500', ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lymphohistiocytic and granulomatous phlebitis in penile lichen sclerosus. | Lichen sclerosus (LS) is a chronic inflammatory disease of unknown etiology that may affect the genital and/or extragenital skin of individuals of either sex at all ages. In boys, the prepuce is the most common site of involvement. The diagnostic criteria of LS include the presence of inflammatory infiltrates mainly co... | ['Adolescent', 'Antigens, CD', 'Child', 'DNA, Viral', 'Granuloma', 'Histiocytes', 'Humans', 'Immunohistochemistry', 'Lichen Sclerosus et Atrophicus', 'Lymphocytes', 'Male', 'Papillomaviridae', 'Penile Diseases', 'Phlebitis', 'Polymerase Chain Reaction'] | 10,949,456 | [['M01.060.057'], ['D23.050.301.264.035', 'D23.101.100.110'], ['M01.060.406'], ['D13.444.308.568'], ['C15.604.515.292', 'C23.550.382'], ['A11.329.372.385', 'A11.627.482.385', 'A11.733.397.385', 'A15.382.670.522.385', 'A15.382.680.397.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Genetic variation in leaf pigment, optical and photosynthetic function among diverse phenotypes of Metrosideros polymorpha grown in a common garden. | Coordinated variation has been reported for leaf structure, composition and function, across and within species, and theoretically should occur across populations of a species that span an extensive environmental range. We focused on Hawaiian keystone tree species Metrosideros polymorpha, specifically, 13-year old tree... | ['Altitude', 'Analysis of Variance', 'Fluorescence', 'Genetic Variation', 'Hawaii', 'Myrtaceae', 'Nitrogen', 'Phenotype', 'Photosynthesis', 'Pigments, Biological', 'Plant Leaves', 'Spectrum Analysis'] | 17,124,568 | [['G16.500.275.058', 'N06.230.058'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['G05.365'], ['Z01.107.567.875.580.375', 'Z01.639.760.815.482'], ['B01.650.940.800.575.912.250.773'], ['D01.268.604', 'D01.362.625'], ['G05.695'], ['G02.111.158... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Isolation, culture and characterization of epithelial cells derived from rat ventral prostate. | Epithelial-cell enriched primary cultures have been established from rat ventral prostate (RVP). Minced ventral prostates were dissociated with 0.5% collagenase in F12K tissue culture medium containing 1% fetal bovine serum. This treatment resulted in the gradual removal of stromal elements from the base of the epithel... | ['Animals', 'Cell Separation', 'Cells, Cultured', 'Epithelial Cells', 'Hydrolases', 'Male', 'Microbial Collagenase', 'Organoids', 'Prostate', 'Rats', 'Succinate Dehydrogenase'] | 6,251,735 | [['B01.050'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.251'], ['A11.436'], ['D08.811.277'], ['D08.811.277.656.300.480.205.500', 'D08.811.277.656.675.374.205.500'], ['A10.802'], ['A05.360.444.575', 'A10.336.707'], ['B01.050.150.900.649.313.992.635.505.700'], ['D05.500.562.750.249.500', 'D08.811.6... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Survival of motor neuron protein over-expression prevents calpain-mediated cleavage and activation of procaspase-3 in differentiated human SH-SY5Y cells. | Spinal muscular atrophy (SMA), a neurodegenerative disorder primarily affecting motor neurons, is the most common genetic cause of infant death. This incurable disease is caused by the absence of a functional SMN1 gene and a reduction in full length survival of motor neuron (SMN) protein. In this study, a neuroprotecti... | ['Animals', 'Apoptosis', 'Calpain', 'Caspase 3', 'Cell Line', 'Cell Line, Tumor', 'Cell Survival', 'Cells, Cultured', 'Enzyme Activation', 'Gene Expression Regulation, Enzymologic', 'Humans', 'Neurons', 'Rats', 'Survival of Motor Neuron 1 Protein'] | 21,333,717 | [['B01.050'], ['G04.146.954.035'], ['D08.811.277.656.262.500.120', 'D08.811.277.656.300.200.120'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['A11.251... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Delirium and stereotypy from anticholinergic antiparkinson drugs. | 1. This report describes two cases of psychotic syndrome from benztropine (Cogentin), which was used to treat haloperidol-induced extrapyramidal side effects. The patients' symptomatology meets DSM III criteria for delirium. Both patients displayed repetitive motor automatisms (stereotypy). 2. Symptomatology appeared o... | ['Adult', 'Aged', 'Benztropine', 'Delirium', 'Diazepam', 'Drug Therapy, Combination', 'Dyskinesia, Drug-Induced', 'Ethchlorvynol', 'Female', 'Haloperidol', 'Humans', 'Imipramine', 'Phenobarbital', 'Psychoses, Substance-Induced', 'Stereotyped Behavior', 'Substance-Related Disorders', 'Tropanes'] | 7,202,232 | [['M01.060.116'], ['M01.060.116.100'], ['D02.145.074.722.270', 'D03.132.889.244', 'D03.605.084.500.722.270', 'D03.605.869.270'], ['C10.597.606.337.500', 'C23.888.592.604.339.500', 'F01.700.250.500', 'F03.615.350'], ['D03.633.100.079.080.070.216'], ['E02.319.310'], ['C10.228.662.262.500', 'C10.597.350.275', 'C10.720.312... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A case of primary hydatidosis of the thyroid gland. | A 54-year-old woman presented with an expansive mass in the anterior cervical region (front of the neck) with abscess. Laboratory tests and thyroid profile proved normal. Surgical exploration revealed a hydatid cyst in the left lobe of the thyroid gland with parasitic metastasis of the left lateral cervical lymph node ... | ['Diagnosis, Differential', 'Echinococcosis', 'Female', 'Humans', 'Middle Aged', 'Thyroid Diseases', 'Thyroid Gland'] | 10,568,129 | [['E01.171'], ['C01.610.335.190.396'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C19.874'], ['A06.300.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
High-throughput transformation method for Yarrowia lipolytica mutant library screening. | As a microorganism of major biotechnological importance, the oleaginous yeast Yarrowia lipolytica is subjected to intensive genetic engineering and functional genomic analysis. Future advancements in this area, however, require a system that will generate a large collection of mutants for high-throughput screening. Her... | ['Gene Library', 'Gene Transfer Techniques', 'Genetic Testing', 'Genetics, Microbial', 'High-Throughput Screening Assays', 'Molecular Biology', 'Plasmids', 'Transformation, Genetic', 'Yarrowia'] | 26,100,263 | [['G05.360.325'], ['E05.393.350'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['H01.158.273.343.330', 'H01.158.273.540.367'], ['E05.916.680'], ['H01.158.201.636', 'H01.158.273.343.595', 'H01.181.122.650'], ['G05.360.600'], ['G05.728.865'], ['B01.300.107.795.980', 'B01.3... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Treating rheumatoid arthritis to target: recommendations assessment questionnaire in Korea. | Treat rheumatoid arthritis (RA) to target (T2T) is an international initiative to provide the rheumatology community with clear direction on treatment targets for RA. We performed a nationwide survey in Korea among rheumatologists to measure the levels of agreement with international T2T recommendations and to assess t... | ['Antirheumatic Agents', 'Arthritis, Rheumatoid', 'Attitude of Health Personnel', 'Humans', 'Physicians', 'Remission Induction', 'Reproducibility of Results', 'Republic of Korea', 'Rheumatology', 'Surveys and Questionnaires', 'Treatment Outcome'] | 24,030,629 | [['D27.505.954.329'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['F01.100.050', 'N05.300.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.810', 'N02.360.810'], ['E02.860'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['Z01.252.474.55... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
[Cancer of the urachus]. | We report a case of mucin-producing adenocarcinoma of the urachus. Preoperative diagnosis was established by computerized axial tomography. An en bloc resection was performed, including the urachus with supravesical mass and bladder dome. | ['Adenocarcinoma', 'Aged', 'Female', 'Follow-Up Studies', 'Humans', 'Tomography, X-Ray Computed', 'Urachus', 'Urinary Bladder Neoplasms'] | 1,484,188 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The in vitro chondrotoxicity of single-dose local anesthetics. | BACKGROUND: The administration of amide-type local anesthetics to cartilaginous tissues has revealed potential chondrotoxicity.PURPOSE: This study evaluated whether administration of single doses of 1% lidocaine, 0.25% bupivacaine, and 0.5% ropivacaine resulted in decreased chondrocyte viability or cartilage matrix deg... | ['Anesthetics, Local', 'Cartilage, Articular', 'Chondrocytes', 'Humans'] | 22,287,644 | [['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['A02.165.407.150', 'A02.835.583.192'], ['A11.329.171'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of cystic duct patency: comparison of functional MR cholangiography with gadoxetate disodium and hepatobiliary scintigraphy in suspected acute cholecystitis. | PURPOSE: This study aims to compare assessment of cystic duct patency between gadoxetate disodium MRI and hepatobiliary scintigraphy.MATERIALS AND METHODS: We performed a prospective study of patients who underwent gadoxetate disodium MRI within 16 h of scintigraphy.RESULTS: The gallbladder filled on MRI and scintigrap... | ['Adult', 'Cholangiopancreatography, Magnetic Resonance', 'Cholecystitis, Acute', 'Contrast Media', 'Cystic Duct', 'Female', 'Gadolinium DTPA', 'Humans', 'Male', 'Predictive Value of Tests', 'Prospective Studies', 'Radionuclide Imaging'] | 27,240,319 | [['M01.060.116'], ['E01.370.350.825.500.100', 'E01.370.372.207'], ['C06.130.564.263.500'], ['D27.505.259.500', 'D27.720.259'], ['A03.159.183.079.450'], ['D02.092.782.590.401', 'D02.241.081.018.639.400', 'D02.257.141'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', '... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Postpartum dissecting aneurysm of the basilar artery. | BACKGROUND AND PURPOSE: Dissecting aneurysms arising from the vertebrobasilar complex are rare and difficult to manage. More of their natural history needs to be known before treatment can be optimized.CASE DESCRIPTION: We report a postpartum dissecting aneurysm of the right vertebrobasilar artery in a 31-year-old woma... | ['Adult', 'Aneurysm, Dissecting', 'Basilar Artery', 'Female', 'Humans', 'Postpartum Period'] | 1,731,411 | [['M01.060.116'], ['C14.907.055.050'], ['A07.015.114.106'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.702']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The primary structure of Cu-Zn superoxide dismutase from Photobacterium leiognathi: evidence for a separate evolution of Cu-Zn superoxide dismutase in bacteria. | The complete amino-acid sequence of the copper-zinc superoxide dismutase of the Photobacterium leiognathi was determined. The fragmentation strategy employed included cyanogen bromide cleavage at its methionine residues and the only tryptophan residue. The S-carboxymethylated chain was further cleaved by means of tryps... | ['Amino Acid Sequence', 'Amino Acids', 'Biological Evolution', 'Chemical Phenomena', 'Chemistry', 'Chromatography, High Pressure Liquid', 'Cyanogen Bromide', 'Photobacterium', 'Superoxide Dismutase', 'Trypsin'] | 6,884,993 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.125'], ['G05.045', 'G16.075'], ['G02'], ['H01.181'], ['E05.196.181.400.300'], ['D01.139.300.050.100', 'D01.625.175'], ['B03.440.450.900.604', 'B03.660.250.830.590'], ['D08.811.682.881'], ['D08.811.277.656.300.760.895', 'D08.811.277.656.959.350.895']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Minimal access aortic root, valve, and complex ascending aortic surgery. | We report our entire experience with minimal access aortic root, valve, and complex ascending aortic surgery. A total of 290 consecutive patients underwent aortic root, valve, and ascending aortic surgery between July 1996 and February 2000. Four groups were identified: isolated aortic valve replacement (AV group, n = ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Aorta', 'Aorta, Thoracic', 'Aortic Diseases', 'Aortic Valve', 'Female', 'Heart Valve Diseases', 'Heart Valve Prosthesis Implantation', 'Humans', 'Male', 'Middle Aged', 'Minimally Invasive Surgical Procedures', 'Prognosis', 'Retrospective Studies', 'Survival Rate', 'Treatment Outc... | 11,060,583 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.015.114.056'], ['A07.015.114.056.372'], ['C14.907.109'], ['A07.541.510.110'], ['C14.280.484'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.502'], ['E01.789'], ['E0... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Antimicrobial activity, antiaflatoxigenic potential and in situ efficacy of novel formulation comprising of Apium graveolens essential oil and its major component. | The present study reports the formulation of Apium graveolens essential oil (AGEO) with its major components linalyl acetate (LA) and geranyl acetate (GA) (1:1:1) as a novel green preservative for protection of postharvest food commodities from fungal infestations, aflatoxin B1 (AFB1) secretion, free radical generation... | ['Aflatoxins', 'Animals', 'Anti-Infective Agents', 'Apium', 'Chromatography, High Pressure Liquid', 'Male', 'Mice', 'Oils, Volatile'] | 31,519,243 | [['D03.383.663.283.119', 'D03.633.100.150.119', 'D23.946.587.142'], ['B01.050'], ['D27.505.954.122'], ['B01.650.940.800.575.912.250.075.094'], ['E05.196.181.400.300'], ['B01.050.150.900.649.313.992.635.505.500'], ['D10.627.675']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SnapShot: SMC Protein Complexes Part II. | This second of two SnapShots on SMC proteins depicts their roles at different stages of the eukaryotic cell cycle. The composition and architecture of SMC protein complexes and their regulators appear in SMC Protein Complexes Part I (available at http://www.cell.com/cell/pdf/S0092-8674%2815%2901690-6.pdf). To view this... | ['Animals', 'Cell Cycle Proteins', 'Chromosomal Proteins, Non-Histone', 'Eukaryotic Cells', 'Humans', 'Multiprotein Complexes'] | 26,871,638 | [['B01.050'], ['D12.776.167'], ['D12.776.660.235', 'D12.776.664.235'], ['A11.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D05.500']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increasing prevalence of diabetes in middle or low income residents in Louisiana from 2000 to 2009. | OBJECTIVE: To examine the trends in the prevalence of diabetes in patients who received medical care from the Louisiana State University Health Care Services Division (LSUHCSD) hospital system between 2000 and 2009.METHODS: The study population included 969,609 unique outpatients and inpatients between 2000 and 2009. T... | ['Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Diabetes Mellitus', 'Female', 'Humans', 'Income', 'International Classification of Diseases', 'Louisiana', 'Male', 'Middle Aged', 'Poverty', 'Prevalence', 'Sex Distribution', 'Time Factors', 'Young Adult'] | 21,889,811 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C18.452.394.750', 'C19.246'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['L01.453.245.945.400'], ['Z01.107.567.875.750.480'], ['M01.060.116.630'], ['I01.880.735.634', 'I01.880... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Radiation response in 10 high-grade human soft tissue sarcoma xenografts to photons and fast neutrons. | From a panel of 48 human soft tissue sarcomas growing as permanent xenografts, 10 tumor lines (five leiomyosarcomas, three malignant fibrous histiocytomas, two neurofibrosarcomas) have been selected to determine the radiation response to photons and fast neutrons. Using the specific growth delay (SGD) as an end-point, ... | ['Animals', 'Cell Line', 'Fast Neutrons', 'Histiocytoma, Benign Fibrous', 'Humans', 'Leiomyosarcoma', 'Mice', 'Mice, Nude', 'Neoplasm Transplantation', 'Neurofibroma', 'Radiation', 'Radiation Tolerance', 'Relative Biological Effectiveness', 'Sarcoma', 'Soft Tissue Neoplasms', 'Transplantation, Heterologous'] | 2,170,308 | [['B01.050'], ['A11.251.210'], ['G01.249.660.250.368'], ['C04.557.450.565.590.425.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.590.455', 'C04.557.450.795.455'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['E05.624'], ['C04.557.580.600.580',... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ocular biometry and refractive outcomes using two swept-source optical coherence tomography-based biometers with segmental or equivalent refractive indices. | This study compared the axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), mean anterior corneal radius of curvature (Rm), and postoperative refractive outcomes obtained from two different swept-source optical coherence biometers, the ARGOS (Movu, Nagoya, Japan), whic... | ['Adult', 'Aged', 'Aged, 80 and over', 'Axial Length, Eye', 'Biometry', 'Cataract', 'Female', 'Humans', 'Interferometry', 'Lenses, Intraocular', 'Male', 'Middle Aged', 'Refractometry', 'Tomography, Optical Coherence'] | 31,024,017 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A09.371.199', 'E01.370.600.115.100.660.500'], ['E05.318.740.225', 'N06.850.505.200'], ['C11.510.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.490'], ['E07.632.500.460', 'E07.695.460'], ['M01.060.116.630'], ['E05.196.808', 'H01.671.617.755... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Genetic markers associated with antibody response kinetics in adult chickens. | A linkage disequilibrium approach with microsatellites was employed to investigate QTL affecting immune response. Highly inbred males of two MHC-congenic Fayoumi chicken lines were mated with highly inbred G-B1 Leghorn hens. Adult F2 hens (n = 158) were injected twice with SRBC and fixed Brucella abortus (BA). Agglutin... | ['Agglutination Tests', 'Animals', 'Antibodies, Bacterial', 'Antibody Formation', 'Brucella abortus', 'Brucellosis', 'Chickens', 'Chromosome Mapping', 'Female', 'Gene Frequency', 'Genotype', 'Kinetics', 'Linkage Disequilibrium', 'Male', 'Microsatellite Repeats', 'Poultry Diseases', 'Quantitative Trait Loci', 'Transform... | 12,762,390 | [['E01.370.225.812.735.050', 'E05.200.812.735.050', 'E05.478.594.760.050'], ['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['G12.450.050.370.250'], ['B03.440.400.425.215.500.100', 'B03.660.050.070.100.100'], ['C01.150.252.400.167'], ['B01.050.150.900.248.350.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pharmacology of all-trans-retinoic acid in children with acute promyelocytic leukemia. | BACKGROUND: Due to severe side effects in virtually all children treated with a standard dose of 45 mg/m(2)/day all-trans-retinoic acid (ATRA) for acute promyelocytic leukemia (APL) the AML-BFM study group reduced the dosage to 25 mg/m(2)/day. For the lack of data on the use of ATRA at this dosage in children with APL,... | ['Adolescent', 'Antineoplastic Agents', 'Antineoplastic Combined Chemotherapy Protocols', 'Child', 'Child, Preschool', 'Dose-Response Relationship, Drug', 'Female', 'Half-Life', 'Humans', 'Infant', 'Leukemia, Promyelocytic, Acute', 'Male', 'Neurotoxicity Syndromes', 'Retinoids', 'Statistics, Nonparametric', 'Tretinoin'... | 12,652,617 | [['M01.060.057'], ['D27.505.954.248'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['M01.060.406'], ['M01.060.406.448'], ['G07.690.773.875', 'G07.690.936.500'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C04.557.337.539.275.700'], ['C10.720', 'C25.723.705'], ['D0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evidence of exercise-induced arterial hypoxemia in prepubescent trained children. | Exercise-induced arterial hypoxemia (EIAH) is a recognized phenomenon in highly trained adults. Like adult athletes, prepubescent trained children may develop high-level metabolic demand but with a limited lung capacity in comparison with adults. The purpose of this investigation was to search for evidence of EIAH in p... | ['Adult', 'Child', 'Exercise', 'Exercise Test', 'Female', 'Humans', 'Hypoxia', 'Male', 'Oxygen', 'Physical Education and Training', 'Puberty', 'Respiratory Function Tests', 'Statistics as Topic'] | 14,739,360 | [['M01.060.116'], ['M01.060.406'], ['G11.427.410.698.277', 'I03.350'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079'], ['D01.268.185.550', 'D01.362.670'], ['I02.233.543'], ['G08.686.760', 'G08.686.841.374'], ['E01.370.386.700'], ['E05.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Macrophage adherence prevents apoptosis induced by ricin. | Ricin, a lectin with potent protein synthesis inhibitory properties, has been known to cause morphological changes in epithelial cells typical of apoptosis (P. Waring et al., Med. Res. Rev. 11, 1-17 (1991)). In earlier preliminary experiments from this laboratory with murine macrophages and T-blasts (P. Waring, J. Biol... | ['Animals', 'Apoptosis', 'Calcium', 'Cell Adhesion', 'Cell Movement', 'Cells, Cultured', 'DNA', 'Dose-Response Relationship, Drug', 'Female', 'Macrophages', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Microscopy, Electron', 'Proteins', 'Ricin', 'Time Factors'] | 7,925,496 | [['B01.050'], ['G04.146.954.035'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.022'], ['G04.198', 'G07.568.500.180'], ['A11.251'], ['D13.444.308'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['B01.050.150.900.649.313.992.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ametoctradin is a potent Qo site inhibitor of the mitochondrial respiration complex III. | Ametoctradin is a new Oomycete-specific fungicide under development by BASF. It is a potent inhibitor of the bc1 complex in mitochondrial respiration. However, its detailed action mechanism remains unknown. In the present work, the binding mode of ametoctradin was first uncovered by integrating molecular docking, MD si... | ['Animals', 'Binding Sites', 'Electron Transport Complex III', 'Fungicides, Industrial', 'Mitochondria', 'Models, Molecular', 'Molecular Docking Simulation', 'Oomycetes', 'Pyrimidines', 'Swine', 'Thermodynamics', 'Triazoles'] | 25,784,492 | [['B01.050'], ['G02.111.570.120'], ['D05.500.562.750.500', 'D08.811.600.250.875.500', 'D08.811.682.830.500', 'D12.776.157.427.374.375.954', 'D12.776.157.530.450.250.875.303', 'D12.776.543.277.875.500', 'D12.776.543.585.450.250.875.468', 'D12.776.556.579.374.375.142'], ['D27.720.031.700.288', 'D27.888.723.288'], ['A11.2... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Environmental alteration and two distinct mechanisms of E. coli adherence to bladder epithelial cells. | We used an in vitro model to investigate Escherichia coli attachment to transitional epithelial cells obtained from bladders of female rats. Adhesive abilities and sensitivity to mannose inhibition differed among the isolates for both epithelial cells and erythrocytes. Adherence of some strains could be modulated by ba... | ['Animals', 'Cell Membrane', 'Culture Media', 'Epithelium', 'Escherichia coli', 'Female', 'Fimbriae, Bacterial', 'Hemagglutination Inhibition Tests', 'Hemagglutination Tests', 'Mannose', 'Rats', 'Urinary Bladder'] | 6,110,645 | [['B01.050'], ['A11.284.149'], ['D27.720.470.305', 'E07.206'], ['A10.272'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['A11.284.180.285', 'A20.843'], ['E01.370.225.812.735.370', 'E05.200.812.735.370', 'E05.478.594.760.370'], ['E01.370.225.812.735.050.375', 'E05.200.812.735.050.375', 'E05.478.594.760.050.3... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Computer-based test-bed for clinical assessment of hand/wrist feed-forward neuroprosthetic controllers using artificial neural networks. | Neuroprosthestic systems can be used to restore hand grasp and wrist control in individuals with C5/C6 spinal cord injury. A computer-based system was developed for the implementation, tuning and clinical assessment of neuroprosthetic controllers, using off-the-shelf hardware and software. The computer system turned a ... | ['Computer Simulation', 'Electric Stimulation', 'Equipment Design', 'Feedback', 'Hand', 'Humans', 'Microcomputers', 'Muscle, Skeletal', 'Neural Networks, Computer', 'Prostheses and Implants', 'Time Factors', 'Wrist'] | 15,587,466 | [['L01.224.160'], ['E05.723.402'], ['E05.320'], ['L01.906.394.211'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.260.550'], ['A02.633.567', 'A10.690.552.500'], ['G17.485', 'L01.224.050.375.605'], ['E07.695'], ['G01.910.857'], ['A01.378.800.875']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Optimization of parameters for anaerobic co-metabolic degradation of TBBPA. | The addition of different carbon and nitrogen sources can promote tetrabromobisphenol A degradation to varying degrees under co-metabolism process. A kinetic model was developed to evaluate the degradation efficiency using different carbon and nitrogen sources. Sodium formate was found to be the best carbon source for ... | ['Anaerobiosis', 'Analysis of Variance', 'Biodegradation, Environmental', 'Carbon', 'Kinetics', 'Nitrogen', 'Polybrominated Biphenyls', 'Surface Properties'] | 24,063,822 | [['G02.111.062', 'G03.078'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['D01.268.150'], ['G01.374.661', 'G02.111.490'], ['D01.268.604', 'D01.362.625'], ['D02.455.426.559.389.185.680', 'D02.455.526.368.700'], ['G02.860']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cerebrospinal fluid amine metabolites, tryptophan and clinical parameters in depression. Part 2. Psychopathological symptoms. | The group of 33 severely depressed female patients was divided into 3 equally large subgroups, separately according to their CSF 5-HIAA, HVA, tryptophan and total plasma tryptophan, and the severity of 17 operationally defined psychopathological symptoms was compared between the subgroups containing the highest and low... | ['Anxiety', 'Depressive Disorder', 'Female', 'Homovanillic Acid', 'Humans', 'Hydroxyindoleacetic Acid', 'Phenylacetates', 'Psychomotor Agitation', 'Sleep Initiation and Maintenance Disorders', 'Suicide, Attempted', 'Tryptophan'] | 6,166,645 | [['F01.470.132'], ['F03.600.300'], ['D02.241.223.601.521'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.066.288.478', 'D03.633.100.473.404.478'], ['D02.241.223.601'], ['C10.597.350.600', 'C10.597.606.881.700', 'C23.888.592.350.600', 'C23.888.592.604.882.700', 'F01.700.875.700'], ['C10.886.425.800.800', 'F03.... | ['Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Determination of sequential mutation accumulation in pancreas and bile duct brushing cytology. | Neoplastic progression is characterized by clonal expansion of tumor cells associated with accumulation of mutational damage. The timing of mutation acquisition could be of value in distinguishing preneoplastic conditions from early and advanced cancer as well as characterizing tumor aggressiveness and treatment respon... | ['Biliary Tract Neoplasms', 'Cell Transformation, Neoplastic', 'Chromosomes, Human, Pair 1', 'Chromosomes, Human, Pair 17', 'Chromosomes, Human, Pair 3', 'Cytodiagnosis', 'DNA Mutational Analysis', 'DNA, Neoplasm', 'Disease Progression', 'Genotype', 'Humans', 'Microdissection', 'Mutation', 'Pancreatic Neoplasms', 'Retr... | 16,648,872 | [['C04.588.274.120', 'C06.130.320', 'C06.301.120'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.284.187.520.300.235.240', 'G05.360.162.520.300.235.240'], ['A11.284.187.520.300.415.425', 'G05.360.162.520.300.415.425'], ['A11.284.187.520.300.235.250', 'G05.360.162.520.300.235.250'], ['E01.370.225.500.384', 'E05.200... | ['Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Emphysematous epididymo-orchitis as a camouflage of prostate invasion secondary to rectum cancer: A case report. | INTRODUCTION: Emphysematous epididymo-orchitis is a rare cause of acute scrotum pain characterized by gas formation within the tissue. Diabetes mellitus and recto-seminal fistula secondary to sigmoid diverticulitis are generally accepted as being responsible for this disease. However, prostate invasion secondary to rec... | ['Acute Pain', 'Adenocarcinoma', 'Aged', 'Colorectal Neoplasms', 'Diagnostic Errors', 'Emphysema', 'Epididymitis', 'Humans', 'Male', 'Neoplasm Staging', 'Orchitis', 'Prostate', 'Prostatic Neoplasms', 'Rectum', 'Recurrence', 'Tomography, X-Ray Computed'] | 27,472,731 | [['C23.888.592.612.081'], ['C04.557.470.200.025'], ['M01.060.116.100'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['E01.354', 'N02.421.450.280'], ['C23.550.325'], ['C12.294.199'], ['B01.050.150.900.649.313.988.400.112.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
TEOAE amplitude growth, detectability, and response threshold in linear and nonlinear mode and in different time windows. | Transitory evoked otoacoustic emissions (TEOAE) have been recorded in 60 ears of 31 adult volunteers with nearly normal hearing at stimulus levels ranging from 83 dB SPL peak equivalent down to the individual response threshold using linear and nonlinear recording mode. The stimulus level dependence of response inciden... | ['Acoustic Stimulation', 'Adolescent', 'Adult', 'Audiometry', 'Auditory Threshold', 'Cochlea', 'Female', 'Hearing', 'Humans', 'Male', 'Middle Aged', 'Time Factors'] | 17,654,082 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['M01.060.057'], ['M01.060.116'], ['E01.370.382.375.060'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['A09.246.300.246'], ['F02.830.816.263', 'G07.888.500', 'G11.561.790.263'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharide-induced acute lung injury. | Acute respiratory distress syndrome is a life-threatening critical syndrome resulting largely from the accumulation of and the inability to clear pulmonary edema. Protectin DX, an endogenously produced lipid mediator, is believed to exert anti-inflammatory and pro-resolution effects. Protectin DX (5 µg/kg) was injected... | ['Acute Lung Injury', 'Animals', 'Anti-Inflammatory Agents', 'Cells, Cultured', 'Docosahexaenoic Acids', 'Lipopolysaccharides', 'Lung', 'Male', 'Protective Agents', 'Pulmonary Alveoli', 'Rats', 'Rats, Sprague-Dawley', 'Signal Transduction', 'Sodium Channels', 'Sodium-Potassium-Exchanging ATPase'] | 29,700,291 | [['C08.381.520.500'], ['B01.050'], ['D27.505.954.158'], ['A11.251'], ['D10.212.302.380.410.210', 'D10.251.355.337.250', 'D10.627.430.450.375'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['A04.411'], ['D27.505.696.706', 'D27.720.799'], ['A04.411.715'], ['B01.050.150.900... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Financial analysis of chronic transfusion for stroke prevention in sickle cell disease. | Chronic red blood cell transfusion can prevent many of the manifestations of sickle cell disease. The medical costs of chronic transfusion and management of associated side effects, especially iron overload, are considerable. This study was undertaken to evaluate the financial impact of chronic transfusion for stroke p... | ['Adolescent', 'Anemia, Sickle Cell', 'Child', 'Cost-Benefit Analysis', 'Deferoxamine', 'Erythrocyte Transfusion', 'Health Care Costs', 'Humans', 'Iron Chelating Agents', 'Iron Overload', 'Stroke', 'Treatment Outcome'] | 11,001,885 | [['M01.060.057'], ['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['M01.060.406'], ['N03.219.151.125'], ['D02.092.570.394.265', 'D02.241.511.372.265'], ['E02.095.135.140.275'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.914.50... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Raf/MEK/ERK signaling inhibition enhances the ability of dequalinium to induce apoptosis in the human leukemic cell line K562. | Delocalized lipophilic cations, such as dequalinium (DQA), selectively accumulate in mitochondria and display anticancer activity in cells from different malignancies. Previous studies in K562 human leukemic cells indicate that DQA causes cell damage as a consequence of an early disturbance in the mitochondrial functio... | ['Apoptosis', 'Cell Line, Tumor', 'Dequalinium', 'Extracellular Signal-Regulated MAP Kinases', 'Fusion Proteins, bcr-abl', 'Humans', 'Mitogen-Activated Protein Kinase Kinases', 'Phosphoinositide-3 Kinase Inhibitors', 'Protein-Tyrosine Kinases', 'Signal Transduction', 'raf Kinases'] | 22,875,343 | [['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['D03.633.100.810.824.200'], ['D08.811.913.696.620.682.700.567.249', 'D12.644.360.450.169', 'D12.776.476.450.169'], ['D08.811.913.696.620.682.725.500.500', 'D12.776.602.500.500.100', 'D12.776.624.664.500.100', 'D12.776.624.664.700.171.500'], ['B01.050.150.90... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Parathyroid adenoma presenting with spontaneous cervical and anterior mediastinal hemorrhage: A case report. | RATIONALE: Spontaneous anterior cervical or mediastinal hemorrhage is a rare presentation of parathyroid adenoma.PATIENT CONCERNS: A 69-year-old woman presented with neck hematoma and dysphagia and was found to have a soft tissue mass adjacent to her thyroid gland as seen on MRI and neck ultrasound.DIAGNOSIS: Laborator... | ['Adenoma', 'Aged', 'Female', 'Hematoma', 'Humans', 'Mediastinal Diseases', 'Neck', 'Parathyroid Neoplasms', 'Parathyroidectomy', 'Thyroidectomy'] | 30,702,621 | [['C04.557.470.035'], ['M01.060.116.100'], ['C23.550.414.838'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.846.187'], ['A01.598'], ['C04.588.322.525', 'C04.588.443.680', 'C19.344.525', 'C19.642.713'], ['E04.270.694'], ['E04.270.856']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Alteration of cardiac glucose metabolism in association to low birth weight: experimental evidence in lambs with left ventricular hypertrophy. | OBJECTIVE: Intrauterine growth restriction that results in low birth weight (LBW) has been linked to the onset of pathological cardiac hypertrophy. An altered transition from a fetal to an adult energy metabolism phenotype, with increased reliance on glucose rather than fatty acids for energy production, could help exp... | ['Animals', 'Biomarkers', 'Blotting, Western', 'Fatty Acids', 'Female', 'Glucose', 'Glucose Transporter Type 1', 'Glucose Transporter Type 4', 'Glycogen', 'Glycogen Synthase Kinase 3', 'Hypertrophy, Left Ventricular', 'Infant, Low Birth Weight', 'Mitochondria', 'Myocardium', 'Myocytes, Cardiac', 'Protein Kinases', 'Rea... | 23,928,106 | [['B01.050'], ['D23.101'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D10.251'], ['D09.947.875.359.448'], ['D12.776.157.530.500.500.500', 'D12.776.157.530.937.563.500', 'D12.776.543.585.500.500.500', 'D12.776.543.585.937.625.500'], ['D12.776.157.530.500.500.93... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The Beers criteria: Not just for geriatrics anymore? Analysis of Beers criteria medications in nongeriatric trauma patients and their association with falls. | BACKGROUND: It has been well established that many classes of medications on the Beers list of Potentially Inappropriate Medications (PIMs) are associated with falls and injuries in the geriatric population, but little work has been performed to understand if similar relationships exist among the nongeriatric adult pop... | ['Accidental Falls', 'Adolescent', 'Adult', 'Female', 'Humans', 'Inappropriate Prescribing', 'Male', 'Medication Reconciliation', 'Middle Aged', 'Potentially Inappropriate Medication List', 'Prescription Drugs', 'Retrospective Studies', 'Wounds and Injuries', 'Young Adult'] | 31,259,873 | [['N06.850.135.122'], ['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.490', 'N02.421.450.500.249'], ['E02.319.529.500', 'N02.421.450.500.500', 'N04.452.528.460', 'N04.590.656'], ['M01.060.116.630'], ['N04.761.700.615', 'N05.700.594'], ['D26.670'], ['E05.318.372.500.500.500',... | ['Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Calcitonin receptor mRNA expression in TT cells: effect of dexamethasone. | Among the four isoforms of the calcitonin receptor (CTR) described in humans, two differ by the presence of h-CTR1 or absence of h-CTR2 of 16 amino acids in the first intracellular loop. Both receptors are biologically active. The TT cell line derived from a human medullary carcinoma of the thyroid is characterized by ... | ['Autocrine Communication', 'Calcitonin', 'Carcinoma, Medullary', 'Cell Division', 'Dexamethasone', 'Gene Expression Regulation, Neoplastic', 'Glucocorticoids', 'Humans', 'RNA, Messenger', 'RNA, Neoplasm', 'Receptors, Calcitonin', 'Thyroid Neoplasms', 'Tumor Cells, Cultured'] | 9,705,072 | [['G04.085.100'], ['D06.472.699.150', 'D06.472.931.052', 'D12.644.400.095', 'D12.644.548.150', 'D12.776.631.650.095'], ['C04.557.465.625.650.240.315', 'C04.557.470.200.025.370.315', 'C04.557.470.615.315', 'C04.557.580.625.650.240.315'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D04.210... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury. | Matrix metalloproteinases (MMPs) are widely implicated in inflammation and tissue remodeling associated with various neurodegenerative diseases and play an important role in nociception and allodynia. Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) plays a key regulatory role for MMP activities. However, the r... | ['Animals', 'Basigin', 'Extracellular Matrix', 'Ganglia, Spinal', 'Hyperalgesia', 'Male', 'Pain Threshold', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Spinal Nerves', 'Up-Regulation'] | 26,697,232 | [['B01.050'], ['D12.776.395.550.045', 'D12.776.543.550.187', 'D23.050.285.040'], ['A11.284.295.310'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['C10.597.751.791.400', 'C23.888.592.763.770.400'], ['F02.463.593.710.560', 'F02.830.816.444.700', 'G11.561.790.444.700'], ['D13.444.735.544'], ['B01.0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fifty glorious years. | Since the second world war, dentistry has undergone momentous changes, not only in clinical and mechanical developments but also in changes in people's perceptions of what care their dentist can offer them. Dental graduates today will be surprised at the great difference between their own education and that of their 19... | ['Adult', 'Child', 'Dental Care', 'England', 'General Practice, Dental', 'History, 20th Century', 'Humans', 'Schools, Dental', 'Tooth Diseases'] | 9,345,801 | [['M01.060.116'], ['M01.060.406'], ['E06.170', 'N02.421.240.190'], ['Z01.542.363.300'], ['H02.163.342'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.783.495.481'], ['C07.793']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Humanities [K]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Immunological and physiological effects of chronic exposure of Peromyscus leucopus to Aroclor 1254 at a concentration similar to that found at contaminated sites. | Polychlorinated biphenyls (PCBs) are environmental contaminants known to cause adverse health effects to biological systems. Limited data are available on their effects on the immune system of wildlife species. Previously, we found that 4 and 6-week-old white-footed mice (Peromyscus leucopus) born from dams injected wi... | ['Animals', 'Body Burden', 'Cell Count', 'Cell Division', 'Chlorodiphenyl (54% Chlorine)', 'Cytochrome P-450 Enzyme System', 'Diet', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Immunity', 'Immunity, Cellular', 'Leukocyte Count', 'Mitogens', 'Organ Size', 'Peromyscus', 'Pregnancy', 'Prenatal Exposure Delayed Effects... | 12,007,856 | [['B01.050'], ['E05.799.638.231', 'N06.850.460.200'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D02.309.750.500.077', 'D02.455.526.439.773.292.077', 'D02.455.526.439.785.292.077'], ['D08.244.453', 'D08.811.682.690.70... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Evaluation of methyl methanesulfonate, 2,6-diaminotoluene and 5-fluorouracil: Part of the Japanese center for the validation of alternative methods (JaCVAM) international validation study of the in vivo rat alkaline comet assay. | As a part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiative international validation study of the in vivo rat alkaline comet assay (comet assay), we examined methyl methanesulfonate, 2,6-diaminotoluene, and 5-fluorouracil under coded test conditions. Rats were treated orally with the ... | ['Animals', 'Comet Assay', 'DNA Damage', 'Dose-Response Relationship, Drug', 'Fluorouracil', 'Liver', 'Male', 'Methyl Methanesulfonate', 'Phenylenediamines', 'Rats', 'Rats, Sprague-Dawley', 'Reproducibility of Results', 'Stomach'] | 26,212,301 | [['B01.050'], ['E05.196.401.153.150', 'E05.301.300.100.150', 'E05.393.560.150', 'E05.940.560.150'], ['G05.200'], ['G07.690.773.875', 'G07.690.936.500'], ['D03.383.742.698.875.404'], ['A03.620'], ['D02.455.326.146.100.050.500.500', 'D02.886.645.600.055.050.510.500'], ['D02.092.146.651', 'D02.092.782.258.651'], ['B01.050... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A hypertriglyceridemic state increases high sensitivity C-reactive protein of Japanese men with normal glucose tolerance. | Both fasting and postprandial hypertriglyceridemia have been identified as risk markers for cardiovascular disease. High-sensitivity C-reactive protein (hs-CRP), known to independently predict future cardiovascular disease, has also been reported to be a direct participant in the progression of atherosclerosis. We eval... | ['Adult', 'Aged', 'Asian Continental Ancestry Group', 'Body Mass Index', 'C-Reactive Protein', 'Carotid Intima-Media Thickness', 'Cholesterol', 'Cross-Sectional Studies', 'Fasting', 'Glucose', 'Humans', 'Hypertriglyceridemia', 'Insulin Resistance', 'Male', 'Middle Aged', 'Postprandial Period', 'Retrospective Studies'] | 21,948,178 | [['M01.060.116'], ['M01.060.116.100'], ['M01.686.508.200'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['E01.370.350.850.150', 'E01.370.370.180', 'G09.330.210'], ['D04.210.500.247.222.284', 'D04.210.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bone marrow-derived endothelial progenitor cells do not contribute significantly to new vessels during incisional wound healing. | OBJECTIVE: To assess the contribution of bone marrow (BM)-derived endothelial progenitor cells (EPCs) to the neovascularisation of cutaneous incisional wounds.METHODS: Lethally irradiated C57Bl/6 mice were transplanted with BM mononuclear cells from Tie2/lacZ mice, which constitutively overexpressed beta-galactosidase ... | ['Animals', 'Bone Marrow Cells', 'Bone Marrow Transplantation', 'Disease Models, Animal', 'Endothelial Cells', 'Galactosides', 'Gene Expression Regulation, Enzymologic', 'Indoles', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Skin', 'Staining and Labeling', 'Time Factors', 'Transcription, Genetic', 'Whole-Body Ir... | 17,309,830 | [['B01.050'], ['A11.148', 'A15.378.316'], ['E02.095.147.725.040', 'E04.936.580.040'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.436.275'], ['D09.408.320'], ['G05.308.320'], ['D03.633.100.473'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.5... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Infliximab as a rescue therapy for hospitalized patients with severe ulcerative colitis refractory to systemic corticosteroids. | BACKGROUND: Infliximab therapy is effective for the induction and maintenance of clinical remission in patients with moderate to severe ulcerative colitis. However, it has not been studied extensively in hospitalized patients who require colectomy as a rescue therapy for severe ulcerative colitis refractory to intraven... | ['Adrenal Cortex Hormones', 'Adult', 'Anti-Inflammatory Agents', 'Antibodies, Monoclonal', 'Colectomy', 'Colitis, Ulcerative', 'Drug Resistance', 'Drug Therapy, Combination', 'Female', 'Gastrointestinal Agents', 'Humans', 'Infliximab', 'Infusions, Intravenous', 'Injections, Intravenous', 'Inpatients', 'Male', 'Pilot Pr... | 19,005,257 | [['D06.472.040'], ['M01.060.116'], ['D27.505.954.158'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E04.210.219'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['G07.690.773.984'], ['E02.319.310'], ['D27.505.954.48... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Desalting, concentration, and buffer exchange by dialysis and ultrafiltration. | This unit includes a variety of dialysis and ultrafiltration techniques that can be used for desalting, concentration, or buffer exchange. Standard dialysis by diffusion across cellulose tubing is described as a technique for desalting or buffer exchange. Ultrafiltration under pressure can be used either for concentrat... | ['Buffers', 'Dialysis', 'Salts', 'Ultrafiltration'] | 18,429,288 | [['D27.720.470.280'], ['E05.196.353', 'G02.186'], ['D01.786'], ['E04.292.975', 'E05.196.454.807', 'G01.280.807', 'G02.263.807']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
RNA-like conformational properties of a synthetic DNA poly(dA-dU).poly(dA-dU). | Differences in the circular dichroism of poly(dA-dT).poly(dA-dT) and poly(dA-dU).poly(dA-dU) and in its temperature induced changes are reported. A comparison to the data obtained with DNA and RNA indicates that an absence of thymine methyl groups in the polynucleotide results in promoting its RNA-like conformational p... | ['Animals', 'Cattle', 'Circular Dichroism', 'DNA', 'Deoxyribonucleotides', 'Nucleic Acid Conformation', 'Poly A-U', 'Polydeoxyribonucleotides', 'RNA'] | 2,415,126 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.867.151'], ['D13.444.308'], ['D13.695.201'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.695.578.550.500.510', 'D13.695.578.550.750.510'], ['D13.695.578.500'], ['D13.444.735']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Verrucous carcinoma of the endometrium. A case report. | Curettage of a sixty-four-year-old white woman with post-menopausal metrorrhagia revealed pyometra and squamous papilloma, thought to be arising from the cervix. Presence of parakeratotic squamous epithelial cells in endometrial curettage, three years after the first clinical presentation, aroused suspicion of verrucou... | ['Aged', 'Carcinoma, Papillary', 'Female', 'Humans', 'Uterine Neoplasms'] | 3,214,582 | [['M01.060.116.100'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.418.948', 'C13.351.500.852.762', 'C13.351.937.418.875']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Polymorphisms of methylene-tetrahydrofolate reductase and risk of lung cancer: a case-control study. | Previous studies have suggested that low folate intake is associated with increased risk of lung cancer. Methylene-tetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and is thought to influence DNA methylation and nucleotide synthesis. MTHFR is highly polymorphic, and the variant gen... | ['Aged', 'Case-Control Studies', 'Diet', 'Female', 'Folic Acid', 'Humans', 'Lung Neoplasms', 'Male', 'Methylenetetrahydrofolate Reductase (NADPH2)', 'Middle Aged', 'Odds Ratio', 'Oxidoreductases Acting on CH-NH Group Donors', 'Polymorphism, Genetic', 'Risk Factors'] | 11,319,182 | [['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G07.203.650.240'], ['D03.633.100.733.631.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['D08.811.682.662.290', 'D12.776.331.775'], ['M01.060.116.630'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Drug-eluting beads versus conventional chemoembolization for the treatment of unresectable hepatocellular carcinoma. | BACKGROUND AND AIM: Solid demonstrations of superior efficacy of drug-eluting beads transarterial chemoembolization with respect to conventional chemoembolization in hepatocellular carcinoma patients are lacking. The aim of the study was to compare these two techniques in two large cohorts of unresectable hepatocellula... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Antibiotics, Antineoplastic', 'Carcinoma, Hepatocellular', 'Chemoembolization, Therapeutic', 'Cohort Studies', 'Disease Progression', 'Doxorubicin', 'Female', 'Humans', 'Infusions, Intra-Arterial', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Particle Size', 'Proporti... | 26,331,807 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248.106'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E02.520.360.150', 'E02.926.500.150'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C23... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of different breathing maneuvers on internal and external organ motion: use of fiducial markers in dynamic MRI. | PURPOSE: To investigate, with dynamic magnetic resonance imaging (dMRI) and a fiducial marker, the influence of different breathing maneuvers on internal organ and external chest wall motion.METHODS AND MATERIALS: Lung and chest wall motion of 16 healthy subjects (13 male, 3 female) were examined with real-time trueFIS... | ['Abdomen', 'Adult', 'Female', 'Humans', 'Linear Models', 'Lung', 'Lung Neoplasms', 'Magnetic Resonance Imaging', 'Male', 'Movement', 'Respiration', 'Thoracic Wall'] | 15,850,927 | [['A01.923.047'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['A04.411'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.... | ['Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinical significance of microsatellite instability for stage II or III colorectal cancer following adjuvant therapy with doxifluridine. | Microsatellite instability (MSI) is a molecular marker that can provide valuable prognostic information for colorectal cancer (CRC). However, the predictive role of the MSI status remains less clear than its role in prognostication due to mixed results from previous studies. Therefore, this study investigated the usefu... | ['Adult', 'Aged', 'Aged, 80 and over', 'Chemotherapy, Adjuvant', 'Cohort Studies', 'Colorectal Neoplasms', 'Female', 'Floxuridine', 'Humans', 'Male', 'Microsatellite Instability', 'Middle Aged', 'Neoplasm Staging', 'Young Adult'] | 20,953,739 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.186.170', 'E02.319.170'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Journal searching in non-MEDLINE resources on Internet Web sites. | Internet access to the medical journal literature is absorbing the attention of all relevant parties, i.e., publishers, journal vendors, librarians, commercial providers, government agencies, and end users. Journal content on the Web sites spans the range from advertising and ordering information for the print version,... | ['Computer Communication Networks', 'Computer Graphics', 'Databases, Bibliographic', 'Information Storage and Retrieval', 'Online Systems', 'Periodicals as Topic', 'United States'] | 10,173,597 | [['L01.224.230.110'], ['L01.224.108', 'L01.296.110'], ['L01.313.500.750.300.188.300', 'L01.470.750.500'], ['L01.313.500.750.280', 'L01.470'], ['L01.313.500.750.300.742'], ['L01.178.682.829.678'], ['Z01.107.567.875']] | ['Information Science [L]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Potentiometric response of a neutral-carrier-based membrane to aqueous mercury in Cl(-)-rich media. | The unique potentiometric response of mercury sensors was investigated in aqueous Cl(-)-rich media, which are often encountered in natural, especially biological samples. The conventional neutral-carrier-based Hg(II)-ISEs are not practically useful because the Cl(-) concentrations in natural aqueous samples are normall... | ['Calixarenes', 'Chlorides', 'Electrodes', 'Hydrogen-Ion Concentration', 'Membranes, Artificial', 'Mercury', 'Polymers', 'Potentiometry', 'Water'] | 19,359,801 | [['D04.345.025'], ['D01.210.450.150', 'D01.248.497.158.215'], ['E07.305.250'], ['G02.300'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['E05.196.922.750', 'E05.301.710'], ['D01.045.250.875', 'D01.248.497.158.45... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Fabrication of large-area patterned nanostructures for optical applications by nanoskiving. | Cost-effective and convenient methods for fabrication of patterned metallic nanostructures over the large (mm2) areas required for applications in photonics are much needed. In this paper, we demonstrate the fabrication of arrays of closed and open, loop-shaped nanostructures by a technique (nanoskiving) that combines ... | ['Computer Simulation', 'Crystallization', 'Gold', 'Light', 'Macromolecular Substances', 'Materials Testing', 'Models, Chemical', 'Molecular Conformation', 'Nanostructures', 'Nanotechnology', 'Optics and Photonics', 'Particle Size', 'Refractometry', 'Scattering, Radiation', 'Spectrum Analysis, Raman', 'Surface Properti... | 17,665,964 | [['L01.224.160'], ['E05.196.300', 'G02.171'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['D05'], ['E05.570'], ['E05.599.495'], ['G02.111.570.820'], ['J01.637.512'], ['H01.603', 'J01.897.520.600'], ['H01.671.617', 'J01.293.688... | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
The muscarinic cholinergic receptors in the posterior hypothalamus of hypertensive and normotensive rats. | The density of [3H]quinuclidin-3-yl benzilate ([3H]QNB) binding sites in the posterior hypothalamus was determined in spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats at the ages of 1, 3, 11 and 50 weeks. In SHR, even at the early age of 1 week which is prehypertensive, the values obtained were 1.5 times gr... | ['Animals', 'Blood Pressure', 'Hypertension', 'Hypothalamus', 'Hypothalamus, Posterior', 'Kinetics', 'Quinuclidinyl Benzilate', 'Rats', 'Rats, Inbred Strains', 'Receptors, Cholinergic', 'Receptors, Muscarinic'] | 7,160,435 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C14.907.489'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['A08.186.211.180.497.362', 'A08.186.211.200.317.357.362'], ['G01.374.661', 'G02.111.490'], ['D02.241.223.601.238.306.740', 'D02.241.511.085.740', 'D03.605.687.800'], ['B01.050.150.900.649.313.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Viability of Listeria monocytogenes on Boneless, Water-Added Hams, Commercially Prepared with and without Food-Grade Chemicals, during Extended Storage at 4 and/or -2.2°C. | Viability of Listeria monocytogenes was monitored during refrigerated (4°C) and/or frozen (i.e., deep chilling at -2.2°C) storage on casing-cooked hams that were commercially prepared with and without potassium lactate and sodium diacetate (1.6%), buffered vinegar (2.2%), buffered vinegar and potassium lactate (1.7%), ... | ['Acetates', 'Animals', 'Colony Count, Microbial', 'Food Handling', 'Food Preservation', 'Food Preservatives', 'Food Storage', 'Listeria monocytogenes', 'Meat Products', 'Microbial Viability', 'Swine'] | 27,052,866 | [['D02.241.081.018', 'D10.251.400.045'], ['B01.050'], ['E01.370.225.875.220', 'E05.200.875.220'], ['J01.576.423.200'], ['J01.576.423.850.700'], ['D27.720.372.300.385', 'G07.203.300.514.500.700', 'J02.500.514.500.700'], ['J01.576.423.200.387'], ['B03.353.500.500.500', 'B03.510.100.500.500', 'B03.510.460.400.410.485.500'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Immunohistochemistry and lectin histochemistry in sarcomatoid renal cell carcinoma: a comparison with classical renal cell carcinoma. | We investigated the expression of various cell markers in renal cell carcinoma, concentrating particularly on the sarcomatoid variety, using lectin and immunohistochemical techniques. The sarcomatoid variant showed stronger staining in a higher proportion of cases for vimentin and reduced positivity for epithelial memb... | ['Carcinoma', 'Humans', 'Immunohistochemistry', 'Kidney Neoplasms', 'Lectins', 'Membrane Glycoproteins', 'Sarcoma'] | 2,606,455 | [['C04.557.470.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['C04.588.945... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts. | Survival, cumulative labeling indices and chromosomal aberrations were studied in normal, ataxia telangiectasia (AT) and hereditary retinoblastoma fibroblasts after X-irradiation during density-inhibition of growth and immediate release by subculture to low density. The D0 of the survival curves were: normal strains, 1... | ['Ataxia Telangiectasia', 'Cell Survival', 'Cells, Cultured', 'Chromosome Aberrations', 'Eye Neoplasms', 'Fibroblasts', 'Humans', 'Retinoblastoma', 'X-Rays'] | 6,843,573 | [['C10.228.140.252.190.530.060', 'C10.562.100', 'C10.597.350.090.500.530.060', 'C14.907.823.213', 'C16.320.080', 'C16.320.798.250', 'C18.452.284.060', 'C20.673.795.250'], ['G04.346'], ['A11.251'], ['C23.550.210', 'G05.365.590.175'], ['C04.588.364', 'C11.319'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Examining efficacy of "TAT-less" delivery of a peptide against the L-type calcium channel in cardiac ischemia-reperfusion injury. | Increased calcium influx through the L-type Ca(2+) channel or overexpression of the alpha subunit of the channel induces cardiac hypertrophy. Cardiac hypertrophy results from increased oxidative stress and alterations in cell calcium levels following ischemia-reperfusion injury and is an independent risk factor for inc... | ['Amino Acid Sequence', 'Animals', 'Biological Transport, Active', 'Calcium Channel Blockers', 'Calcium Channels, L-Type', 'Drug Delivery Systems', 'Guinea Pigs', 'Magnetite Nanoparticles', 'Models, Molecular', 'Molecular Sequence Data', 'Myocardial Reperfusion Injury', 'Myocytes, Cardiac', 'Nanotechnology', 'Peptide F... | 23,432,114 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G03.143.310'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['D12.776.157.530.400.150.400', 'D12.776.543.550.450.150.400', 'D12.776.543.585.400.150.400'], ['E02.319.300'], ['B01.050.150.900.649.313.992.550'], ['J01.637.512.600.500.144... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Modulation of beta-catenin by cyclin-dependent kinase 6 in Wnt-stimulated cells. | Beta-catenin is implicated in quite different cellular processes, which require a fine-tuned regulation of its function. Here we demonstrate that cyclin-dependent kinase 6 (CDK6), in association with cyclin D1 (CCND1), directly binds to beta-catenin. We showed that CCND1-CDK6 phosphorylates beta-catenin on serine 45 (S... | ['Animals', 'Cattle', 'Cells, Cultured', 'Cyclin D1', 'Cyclin-Dependent Kinase 6', 'Fibroblasts', 'Humans', 'Mice', 'Mice, Knockout', 'Phosphoproteins', 'Phosphorylation', 'Protein Binding', 'Protein Kinases', 'Serine', 'TCF Transcription Factors', 'Trans-Activators', 'Transcription, Genetic', 'Wnt Proteins', 'beta Cat... | 17,208,333 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100', 'D12.776.624.664.700.100'], ['D08.811.913.696.620.682.700.646.500.937', 'D12.644.360.250.515', 'D12.776.167.200.515', 'D12.776.476.250.515'], ['A11.329.228'], ['B01.050.1... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pharmacokinetics of ibuprofen in man--III: Plasma protein binding. | Plasma protein binding of ibuprofen was measured by equilibrium dialysis on 406 plasma samples collected from 15 normal volunteers following doses of 400, 800, and 1200 mg of ibuprofen as tablets (N = 102, 100, 104, respectively) and 420 mg as an aqueous solution (N = 100). Individual subject bound concentration at dia... | ['Adult', 'Blood Proteins', 'Humans', 'Ibuprofen', 'Kinetics', 'Male', 'Protein Binding'] | 6,668,554 | [['M01.060.116'], ['D12.776.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.223.701.430'], ['G01.374.661', 'G02.111.490'], ['G02.111.679', 'G03.808']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[The neuro-endocrinal system status in patients with severe inflammatory colonic diseases]. | There were examined 27 patients with inflammatory diseases of colon. In cases of the nonspecific ulcerative colitis and Crohn's disease of colon the thyroid gland insufficiency occurs in variant of the thriiodinethyronine low contents syndrome, causing the necessity of the substitution therapy conduction in postoperati... | ['Adrenocorticotropic Hormone', 'Colitis, Ulcerative', 'Crohn Disease', 'Humans', 'Hydrocortisone', 'Hypothyroidism', 'Radioimmunoassay', 'Thyroid Hormones'] | 11,247,446 | [['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['C06.405.205.731.500... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A generic strategy for CRISPR-Cas9-mediated gene tagging. | Genome engineering has been greatly enhanced by the availability of Cas9 endonuclease that can be targeted to almost any genomic locus using so called guide RNAs (gRNAs). However, the introduction of foreign DNA sequences to tag an endogenous gene is still cumbersome as it requires the synthesis or cloning of homology ... | ['Bacterial Proteins', 'CRISPR-Associated Protein 9', 'CRISPR-Cas Systems', 'Cell Line', 'DNA', 'Deoxyribonuclease I', 'Endonucleases', 'Genes, Reporter', 'Genetic Engineering', 'Genome, Human', 'Green Fluorescent Proteins', 'Humans', 'Luciferases', 'Microscopy, Fluorescence', 'Plasmids', 'RNA, Guide', 'Reverse Transcr... | 26,674,669 | [['D12.776.097'], ['D08.811.277.352.355.325.150', 'D12.776.097.219', 'D12.776.212.500'], ['G05.308.203.374.394'], ['A11.251.210'], ['D13.444.308'], ['D08.811.277.352.335.350.250'], ['D08.811.277.352.355'], ['G05.360.340.024.340.435'], ['E05.393.420'], ['G05.360.340.350'], ['D12.776.532.265'], ['B01.050.150.900.649.313.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
DEVOTE 3: temporal relationships between severe hypoglycaemia, cardiovascular outcomes and mortality. | AIMS/HYPOTHESIS: The double-blind Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients with Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE) assessed the cardiovascular safety of insulin degludec. The incidence and rates of adjudicated severe hypoglycaemia, and all-cau... | ['Diabetes Mellitus, Type 2', 'Double-Blind Method', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Hypoglycemia', 'Hypoglycemic Agents', 'Insulin Glargine', 'Insulin, Long-Acting', 'Male'] | 28,913,543 | [['C18.452.394.750.149', 'C19.246.300'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381', 'D12.776.422.316.762.380.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.984'], ['D27.505.696.422'], ['D0... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The routine assessment of severity amongst people with mental illness. | BACKGROUND: Specialist mental health services are required to prioritise their work. To help this process numerous definitions of severe mental illness have been suggested. Such definitions vary, and are not necessarily valid or reliable. This investigation examined whether there was agreement over who constituted the ... | ['Adult', 'Aged', 'Community Mental Health Services', 'Female', 'Humans', 'London', 'Male', 'Mental Disorders', 'Middle Aged', 'Needs Assessment', 'Observer Variation', 'Patient Care Planning', 'Practice Guidelines as Topic', 'Psychiatric Status Rating Scales', 'Reproducibility of Results', 'Sampling Studies', 'Severit... | 11,518,034 | [['M01.060.116'], ['M01.060.116.100'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.433.553', 'Z01.542.363.300.553'], ['F03'], ['M01.060.116.630'], ['I02.594', 'N03.349.380.565', 'N05.300.537'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Articular hypermotility syndrome (AHS): clinical characteristics and specific features of AHS-related rheumatoid arthritis and osteoarthritis]. | Articular and extraarticular manifestations of AHS were studied in 114 AHS patients. Locomotor complaints were getting more frequent and serious with progression of AHS. Rheumatoid arthritis arising in the presence of hypermotility was characterized by minor symptoms and destructive changes and was not very active. Fun... | ['Adult', 'Arthritis, Rheumatoid', 'Diagnosis, Differential', 'Female', 'Humans', 'Joint Instability', 'Male', 'Osteoarthritis', 'Range of Motion, Articular', 'Severity of Illness Index', 'Syndrome'] | 9,503,528 | [['M01.060.116'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.521'], ['C05.550.114.606', 'C05.799.613'], ['E01.370.600.700', 'G11.427.760'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.8... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Modes and models of GABA(A) receptor gating. | Upon activation by agonist, the type A gamma-aminobutyric acid receptor (GABAR) 'gates', allowing chloride ions to permeate membranes and produce fast inhibition of neurons. There is no consensus kinetic model for the GABAR gating mechanism. We expressed human alpha(1)beta(1)gamma(2S) GABARs in HEK 293 cells and record... | ['Action Potentials', 'Cell Line', 'Computer Simulation', 'Dose-Response Relationship, Drug', 'Humans', 'Ion Channel Gating', 'Kidney', 'Membrane Potentials', 'Models, Neurological', 'Neural Inhibition', 'Receptors, GABA-A', 'gamma-Aminobutyric Acid'] | 16,455,693 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['A11.251.210'], ['L01.224.160'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.820.400', 'G04.835.400', 'G07.265.625'], ['A05.810.453'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E05.599.395.6... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm. | Delayed ischemic neurological deficit (DIND) is a major driver of adverse outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH), defining an unmet need for therapeutic development. Cell-free hemoglobin that is released from erythrocytes into the cerebrospinal fluid (CSF) is suggested to cause vasoconstric... | ['Animals', 'Basilar Artery', 'Brain', 'Cerebrospinal Fluid', 'Disease Models, Animal', 'Female', 'Haptoglobins', 'Hemoglobins', 'Humans', 'Intracranial Aneurysm', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Proteomics', 'Sheep', 'Signal Transduction', 'Subarachnoid Hemorrhage', 'Subarachnoid Space', 'Swine', 'Vasospasm, In... | 31,454,333 | [['B01.050'], ['A07.015.114.106'], ['A08.186.211'], ['A12.207.270.210'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.776.124.050.300', 'D12.776.124.790.106.394', 'D12.776.377.715.085.394', 'D12.776.395.560.373'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Authentication of the 31 species of Toxic and Potent Chinese Materia Medica (T/PCMM) by microscopic technique, part 2: Three species of seed T/PCMM. | Toxic and Potent Chinese Materia Medica (T/PCMM) are being used more and more in the treatment of various diseases. In view of their toxic side effects and to ensure their safe use, accurate and reliable authentication is indispensable. However, identifying characteristics of T/PCMM are seldom reported, even though mod... | ['Drugs, Chinese Herbal', 'Euphorbia', 'Hyoscyamus', 'Materia Medica', 'Microscopy, Polarization', 'Seeds', 'Strychnos nux-vomica'] | 18,219,667 | [['D20.215.784.500.350', 'D26.335'], ['B01.650.940.800.575.912.250.859.797.438.333'], ['B01.650.940.800.575.912.250.908.500.274'], ['D26.526'], ['E01.370.350.515.624', 'E05.595.624'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500.775'], ['B01.650.940.800.575.912.250.456.875.750.500']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Pd(II) catalyzed ortho C-H iodination of phenylcarbamates at room temperature using cyclic hypervalent iodine reagents. | A novel approach to access ortho iodinated phenols using cyclic hypervalent iodine reagents through palladium(II) catalyzed C-H activation has been developed through weak coordination. The reaction showed excellent regioselectivity, reactivity and good functional group tolerance. A unique mechanism was proposed. | ['Halogenation', 'Indicators and Reagents', 'Iodine', 'Isomerism', 'Palladium', 'Phenylcarbamates', 'Temperature'] | 26,001,095 | [['G02.111.323', 'G03.360'], ['D27.720.470.410'], ['D01.268.380.400'], ['G02.111.570.685', 'G02.607.445'], ['D01.268.556.680', 'D01.268.956.718', 'D01.552.544.680'], ['D02.241.081.251.583'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Echocardiography overestimates LV mass in the elderly as compared to cardiac CT. | PURPOSE: Echocardiographic studies have shown an increase in LV mass with advanced age. However, autopsy and MRI studies demonstrate that with aging, LV mass is unchanged or slightly decreased, with a decrease in LV volume and an increase in wall thickness consistent with concentric remodeling. LV structural remodeling... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Echocardiography', 'Female', 'Heart Ventricles', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Radiography, Thoracic', 'Retrospective Studies', 'Tomography, X-Ray Computed', 'Young Adult'] | 31,648,248 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E01.370.350.700.730'], ['E05.318.372.500.500.500', 'E0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Continuous inhalation of carbon monoxide attenuates hypoxic pulmonary hypertension development presumably through activation of BKCa channels. | OBJECTIVE: We tested the hypothesis that inhalation of a low concentration of exogenous carbon monoxide (CO) attenuates the development of hypoxic pulmonary artery hypertension by activation of large-conductance voltage and Ca(2+)-activated K(+) channels (BK(Ca)).METHODS: The BK(Ca) activity was measured using whole-ce... | ['Animals', 'Calcium', 'Carbon Monoxide', 'Cell Polarity', 'Chronic Disease', 'Drug Administration Schedule', 'Hemodynamics', 'Hypertension, Pulmonary', 'Hypoxia', 'Male', 'Membrane Potentials', 'Muscle Cells', 'Muscle, Smooth', 'Patch-Clamp Techniques', 'Peptides', 'Potassium Channels, Calcium-Activated', 'Rats', 'Rat... | 15,664,403 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D01.200.250', 'D01.362.200', 'D01.650.550.250'], ['G04.250'], ['C23.550.291.500'], ['E02.319.283'], ['G09.330.380'], ['C08.381.423', 'C14.907.489.556'], ['C23.888.852.079'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['A11.620'], ['A0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Activation of adenosine A(3) receptors supports hematopoiesis-stimulating effects of granulocyte colony-stimulating factor in sublethally irradiated mice. | PURPOSE: Research areas of 'post-exposure treatment' and 'cytokines and growth factors' have top priority among studies aimed at radiological nuclear threat countermeasures. The experiments were aimed at testing the ability of N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA), an adenosine A(3) receptor agoni... | ['Adenosine', 'Animals', 'Erythroid Precursor Cells', 'Granulocyte Colony-Stimulating Factor', 'Hematopoiesis', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Receptor, Adenosine A3', 'Whole-Body Irradiation'] | 20,586,541 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['B01.050'], ['A11.148.378.590.837.250', 'A11.443.240.497', 'A11.872.378.590.817.250', 'A15.378.316.378.590.837.250'], ['D12.644.276.374.410.240.350', 'D12.776.395.240.200', 'D12.776.467.374.410.240.350', 'D23.529.374.410.240.350'], ['G04.152.825', 'G0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The transfer of movement sequences: effects of decreased and increased load. | A number of recent experiments have demonstrated that a movement structure develops during the course of learning a movement sequence that provides the basis for transfer. After learning a movement sequence participants have been shown to be able to effectively produce the sequence when movement demands require that th... | ['Biomechanical Phenomena', 'Electromyography', 'Humans', 'Motor Skills', 'Movement', 'Muscle Contraction', 'Practice, Psychological', 'Retention, Psychology', 'Serial Learning', 'Students', 'Task Performance and Analysis', 'Time Factors', 'Transfer, Psychology', 'Weight-Bearing'] | 17,514,593 | [['G01.154.090', 'G01.374.089'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.808.260'], ['G07.568', 'G11.427.410'], ['G11.427.494'], ['F02.463.425.674'], ['F02.463.425.540.772'], ['F02.463.425.952.747'], ['M01.848'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600'... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Transition metal cations extraction by ester and ketone derivatives of chromogenic azocalix[4]arenes. | The molecule of azocalix[n]arene is a macrocyclic used effectively in the complexation of the heavy metal pollutants (like silver and mercury). In this work, our main aim is to prepare new chromogenic azocalix[n]arene molecules to elaborate an extractant with high extractant selectivity for metal ions able to detect th... | ['Azo Compounds', 'Calixarenes', 'Environmental Pollutants', 'Esters', 'Ketones', 'Ligands', 'Metals', 'Phenols', 'Picrates'] | 18,023,970 | [['D02.172'], ['D04.345.025'], ['D27.888.284'], ['D02.241.400'], ['D02.522'], ['D27.720.470.480'], ['D01.552'], ['D02.455.426.559.389.657'], ['D02.455.426.559.389.657.566.690', 'D02.640.743.690']] | ['Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Recursive Mahalanobis separability measure for gene subset selection. | Mahalanobis class separability measure provides an effective evaluation of the discriminative power of a feature subset, and is widely used in feature selection. However, this measure is computationally intensive or even prohibitive when it is applied to gene expression data. In this study, a recursive approach to Maha... | ['Algorithms', 'Computational Biology', 'Data Interpretation, Statistical', 'Data Mining', 'Databases, Genetic', 'Gene Expression Profiling', 'Humans', 'Neoplasms', 'Oligonucleotide Array Sequence Analysis', 'Regression Analysis'] | 20,479,500 | [['G17.035', 'L01.224.050'], ['H01.158.273.180', 'L01.313.124'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['L01.313.500.750.280.199', 'L01.470.625'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['E05.393.332'], ['B01.050.150.900.649.313... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
[Study of growth hormone in spontaneous dwarf rat]. | In 1977, in the Research Laboratories, Morishita Pharmaceutical Co. Ltd., we were fortunate to discover that small mutant rats named Spontaneous Dwarf Rat (gene symbol dr), inherited an autosomal recessive. In previous papers, we reported that these rats might be characterized by a defect of growth hormone (GH). In thi... | ['Animals', 'Dwarfism', 'Growth Hormone', 'Pituitary Gland, Anterior', 'Rats', 'Rats, Inbred Strains'] | 6,510,538 | [['B01.050'], ['C05.116.099.343', 'C16.320.240', 'C19.297'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['A06.300.747.500', 'A06.688.357.750.500', 'A08.186.211.180.497.352.435.500.500', 'A08.186.211.200.317.357.352.435.500.500', 'A08.713.357.750.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Conformational dynamics of a biologically active three-fragment complex of horse cytochrome c. | The conformational dynamics of a biologically active noncovalent complex containing three fragments, ferroheme fragment (1-25)H and apofragments (28-38) and [3H](56-104) [or [3H](39-104)], of horse cytochrome c has been studied with respect to kinetics and thermodynamics of dissociation. The rate of unfolding of the tw... | ['Animals', 'Cytochrome c Group', 'Horses', 'Kinetics', 'Motion', 'Protein Conformation', 'Structure-Activity Relationship', 'Temperature', 'Thermodynamics'] | 6,281,788 | [['B01.050'], ['D08.244.286', 'D12.776.422.220.286'], ['B01.050.150.900.649.313.984.235.472'], ['G01.374.661', 'G02.111.490'], ['G01.482'], ['G02.111.570.820.709'], ['G02.111.830', 'G07.690.773.997'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Prevalence of Trichomonas vaginalis in women of reproductive age at a family health clinic. | INTRODUCTION: Trichomonas vaginalis is considered the most prevalent curable sexually transmitted infection, and its occurrence exceeds that of gonococcal and chlamydia infections. This parasite has been identified as responsible for the increased risk of transmission of HIV and has also been associated with prostate a... | ['Adolescent', 'Adult', 'Brazil', 'Cross-Sectional Studies', 'Female', 'Humans', 'Hydrogen-Ion Concentration', 'Middle Aged', 'Prevalence', 'Risk Factors', 'Sexual Behavior', 'Surveys and Questionnaires', 'Trichomonas Infections', 'Trichomonas vaginalis', 'Vagina', 'Young Adult'] | 28,368,862 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.757.176'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['M01.060.116.630'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Evidence for telomerase activation in VSMCs exposed to hyperglycemic and hyperhomocysteinemic conditions. | PURPOSE: While diabetes and homocysteinemia have been demonstrated to be independent risk factors for progression of vascular disease, the activation of telomerase has not been linked to the potent effects of high levels of homocysteine (Hcy) and glucose on vascular smooth muscle cells (VSMC). We examined the prolifera... | ['Cell Proliferation', 'Cell Survival', 'Cells, Cultured', 'Enzyme Activation', 'Glucose', 'Homocysteine', 'Humans', 'Hyperglycemia', 'Hyperhomocysteinemia', 'Muscle, Smooth, Vascular', 'Myocytes, Smooth Muscle', 'Phosphorylation', 'Signal Transduction', 'Telomerase', 'Time Factors', 'p38 Mitogen-Activated Protein Kina... | 19,398,425 | [['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['A11.251'], ['G02.111.263', 'G03.328'], ['D09.947.875.359.448'], ['D02.886.030.498', 'D12.125.166.498'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.952'], ['C16.320.565.100.480', 'C18.452.603.378', 'C18.452.648.100.480', 'C18.654.521.500.133.699... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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