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SAPPHIRE: scenarios, architecture, and process. | General Medical Practice (GMP) information systems within the UK are becoming more sophisticated and more complex and are widely available from numerous suppliers. Although such systems are viewed as being important, they are problematic in terms of interpreting and assessing their usefulness, and their impact upon wor... | ['Accreditation', 'Family Practice', 'Humans', 'Information Systems', 'Software', 'Software Design', 'Systems Integration', 'United Kingdom', 'User-Computer Interface'] | 7,956,163 | [['N03.706.110.070', 'N05.700.200.100'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.313.500.750.300'], ['L01.224.900'], ['L01.224.900.820'], ['H01.770.787', 'L01.906.787'], ['Z01.542.363'], ['L01.224.900.910']] | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Comparison of cyclophosphamide, cytarabine, and etoposide as immunosuppressive agents before allogeneic bone marrow transplantation. | Etoposide and cytarabine have been shown to exert high antileukemic activity and are currently under study as preparatory agents before allogeneic bone marrow transplantation. However, data concerning their engraftment-promoting potency are scarce. Therefore, we tested these agents in LEW rats receiving a myeloablative... | ['Animals', 'Bone Marrow Transplantation', 'Busulfan', 'Cyclophosphamide', 'Cytarabine', 'Dose-Response Relationship, Radiation', 'Etoposide', 'Graft Survival', 'Immunosuppression', 'Rats', 'Rats, Inbred Strains', 'Skin Transplantation', 'Whole-Body Irradiation'] | 3,052,627 | [['B01.050'], ['E02.095.147.725.040', 'E04.936.580.040'], ['D02.033.455.125.125', 'D02.455.326.146.100.050.500.100', 'D02.886.645.600.055.050.510.100'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['E05.799.513.500', 'G01.750.740.500', '... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol. | BACKGROUND AND OBJECTIVES: A single-nucleotide polymorphism (SNP) of the human multidrug-resistance gene in wobble position of exon 26 reportedly predicts expression and function of P-glycoprotein in human enterocytes and lymphocytes. Several other allelic variants of MDR1 have been identified, some of which lead to am... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Adult', 'Area Under Curve', 'Duodenum', 'Female', 'Genes, MDR', 'Genotype', 'Humans', 'Male', 'Polymorphism, Genetic', 'Propanolamines', 'RNA, Messenger'] | 12,426,521 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['M01.060.116'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['A03.556.12... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Resting membrane potential as a marker of apoptosis: studies on Xenopus oocytes microinjected with cytochrome c. | Observation of the electrical potential difference across the cell membrane is described as a new method for monitoring apoptosis of a single cell. The resting membrane potential (DeltaPsi) of Xenopus oocytes has been recorded in real time following microinjection of cytochrome c. Soon after microinjection, DeltaPsi be... | ['Animals', 'Apoptosis', 'Caspase Inhibitors', 'Caspases', 'Cell Membrane', 'Cytochrome c Group', 'Cytochromes c', 'Enzyme Activation', 'Enzyme Inhibitors', 'Membrane Potentials', 'Microinjections', 'Oocytes', 'Oxidation-Reduction', 'Peptide Hydrolases', 'Protein Conformation', 'Saccharomyces cerevisiae Proteins', 'Sig... | 11,313,704 | [['B01.050'], ['G04.146.954.035'], ['D27.505.519.389.745.325.500'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['A11.284.149'], ['D08.244.286', 'D12.776.422.220.286'], ['D08.244.286.100', 'D12.776.422.220.286.100'], ['G02.111.263', 'G03.328'], ['D27.505... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A conserved carboxy-terminal domain in the major tegument structural protein VP22 facilitates virion packaging of a chimeric protein during productive herpes simplex virus 1 infection. | Recombinant virus HSV-1(RF177) was previously generated to examine tegument protein VP22 function by inserting the GFP gene into the gene encoding VP22. During a detailed analysis of this virus, we discovered that RF177 produces a novel fusion protein between the last 15 amino acids of VP22 and GFP, termed GCT-VP22. Th... | ['Amino Acid Sequence', 'Animals', 'Chlorocebus aethiops', 'Conserved Sequence', 'Herpes Simplex', 'Herpesvirus 1, Human', 'Protein Structure, Tertiary', 'Recombination, Genetic', 'Vero Cells', 'Viral Structural Proteins', 'Virus Assembly'] | 19,307,008 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['G02.111.570.580'], ['C01.925.256.466.382', 'C01.925.825.320', 'C17.800.838.790.320'], ['B04.280.382.100.750.390'], ['G02.111.570.820.709.610'], ['G05.728'], ['A11.251.210.955', 'A11.436.955'], ['D12.776.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
TrkA amino acids controlling specificity for nerve growth factor. | Neurotrophins are important for the development and maintenance of the vertebrate nervous system, mediating their signal into the cell by specific interaction with tyrosine kinase receptors of the Trk family. The extracellular portion of the Trk receptors has been previously proposed to consist of a cysteine-rich motif... | ['Amino Acid Sequence', 'Amino Acids', 'Binding Sites', 'Brain-Derived Neurotrophic Factor', 'Humans', 'Models, Molecular', 'Molecular Sequence Data', 'Nerve Growth Factor', 'Neurotrophin 3', 'Protein Binding', 'Protein Engineering', 'Receptor, trkA', 'Receptor, trkC', 'Sequence Homology, Amino Acid'] | 10,713,102 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.125'], ['G02.111.570.120'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['L01.453.245.667'], ['D12.644.276.860.437', 'D12.776.467.860.437', 'D12.776.631.600.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Histological reassessment of three kidneys originally described by Richard Bright in 1827-36. | Portions of kidney from three patients with renal disease that were originally described by Richard Bright between 1827 and 1836 have been preserved in the Gordon Museum at Guy's Hospital. Histological study has shown that two cases fall into the current diagnostic category of mesangiocapillary (membranoproliferative) ... | ['Adult', 'Edema', 'Female', 'Glomerulonephritis', 'History, 19th Century', 'Humans', 'Kidney', 'Kidney Failure, Chronic', 'Kidney Glomerulus', 'London', 'Male', 'Nephrotic Syndrome', 'Pathology', 'Staining and Labeling', 'Uremia'] | 4,113,938 | [['M01.060.116'], ['C23.888.277'], ['C12.777.419.570.363', 'C13.351.968.419.570.363'], ['K01.400.504.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['A05.810.453.324.359', 'A05.810.453.736.520'], ['Z01.433.553', 'Z01.542.363.300.553']... | ['Named Groups [M]', 'Diseases [C]', 'Humanities [K]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 |
Hot-flashes in breast cancer survivors: effectiveness of low-dosage fluoxetine. A pilot study. | Breast carcinoma survivors suffering from hot-flashes experience a negative impact on their quality of life. Antidepressants have recently been proven to be effective in these women, significantly reducing the vasomotor symptoms. With this in mind, a single-arm clinical trial low-dose regimen of Fluoxetine (10 mg/day f... | ['Adult', 'Breast Neoplasms', 'Dose-Response Relationship, Drug', 'Female', 'Fluoxetine', 'Hot Flashes', 'Humans', 'Middle Aged', 'Pilot Projects', 'Serotonin Uptake Inhibitors', 'Treatment Outcome'] | 16,270,523 | [['M01.060.116'], ['C04.588.180', 'C17.800.090.500'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.092.831.280'], ['C23.888.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['D27.505.519.562.437.850', 'D27.505... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Fibroblast populated collagen matrix promotes islet survival and reduces the number of islets required for diabetes reversal. | Islet transplantation represents a viable treatment for type 1 diabetes. However, due to loss of substantial mass of islets early after transplantation, islets from two or more donors are required to achieve insulin independence. Islet-extracellular matrix disengagement, which occurs during islet isolation process, lea... | ['Animals', 'Apoptosis', 'Blood Glucose', 'Cell Proliferation', 'Cells, Cultured', 'Coculture Techniques', 'Collagen Type I', 'Diabetes Mellitus, Experimental', 'Fibroblasts', 'Fibronectins', 'Graft Survival', 'Insulin', 'Intercellular Signaling Peptides and Proteins', 'Islets of Langerhans', 'Islets of Langerhans Tran... | 21,506,112 | [['B01.050'], ['G04.146.954.035'], ['D09.947.875.359.448.500'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['E05.481.500.374'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['A11.329.228'], ['D12.776.377.715.390', 'D12.776.395.550.350',... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Postpartum contraception: effect of lynestrenol during the lactation period (author's transl)]. | 167 women were treated with 0.5 mg lynestrenol/day for a period of 8-32 weeks immediately postpartum. The lactation periods of 67 of the women were observed during the stay in hospital (maximum 7 days) in comparison with a control group (n = 20) of untreated women in the puerperium. There was no quantitative difference... | ['Adolescent', 'Adult', 'Cervix Mucus', 'Female', 'Humans', 'Lactation', 'Lynestrenol', 'Menstruation Disturbances', 'Milk, Human', 'Platelet Aggregation', 'Postpartum Period', 'Pregnancy'] | 408,604 | [['M01.060.057'], ['M01.060.116'], ['A12.200.503.339'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.523', 'G08.686.702.500'], ['D04.210.500.668.651.693.494'], ['C23.550.568'], ['A12.200.467', 'A12.790.500', 'G07.203.100.700.500', 'G07.203.300.350.525.500', 'J02.200.700.500', 'J02.500.350.525.500'], ['G09... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
The role of dexamethasone on decreasing urinary cytokines in children with acute pyelonephritis. | Cytokines play a major role in renal scar formation following febrile urinary tract infection (UTI). We investigated the role of dexamethasone combined with antibiotics in diminishing urinary interleukin-6 (UIL-6) and UIL-8 concentrations during the acute phase of pyelonephritis compared with standard antibiotic therap... | ['Acute Disease', 'Ceftriaxone', 'Child', 'Child, Preschool', 'Cicatrix', 'Creatinine', 'Cytokines', 'Dexamethasone', 'Female', 'Humans', 'Infant', 'Interleukin-6', 'Interleukin-8', 'Leukocyte Count', 'Male', 'Pyelonephritis', 'Urinary Tract Infections', 'Vesico-Ureteral Reflux'] | 18,551,321 | [['C23.550.291.125'], ['D02.065.589.099.249.190.190.155', 'D02.886.665.074.190.190.155', 'D03.633.100.300.249.190.190.155'], ['M01.060.406'], ['M01.060.406.448'], ['A10.165.450.300', 'C23.550.355.274', 'G16.762.891.249'], ['D03.383.129.308.207'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D04.210.500.745.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4. | PURPOSE: Bone defects and nonunions are major clinical skeletal problems. Growth factors are commonly used to promote bone regeneration; however, the clinical impact is limited because the factors do not last long at a given site. The introduction of tissue engineering aimed to deter the diffusion of these factors is a... | ['Animals', 'Bone Morphogenetic Protein 4', 'Collagen', 'Drug Carriers', 'Female', 'Fibronectins', 'Histocytochemistry', 'Humans', 'Mice', 'Nanoparticles', 'Osteogenesis', 'Rabbits', 'Recombinant Fusion Proteins', 'Skull', 'Tissue Engineering', 'Tissue Scaffolds'] | 23,630,418 | [['B01.050'], ['D12.644.276.954.200.400', 'D12.776.467.942.200.400', 'D23.529.942.200.400'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D26.255.260', 'E02.319.300.380'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Enhanced sorption of polycyclic aromatic hydrocarbons from aqueous solution by modified pine bark. | To enhance removal efficiency of natural sorbent with polycyclic aromatic hydrocarbons (PAHs), single-solute and bi-solute sorption of phenanthrene and pyrene onto raw and modified pine bark were investigated. Pine bark was modified using Soxhlet extraction, saponification and acid hydrolysis, yielding six bark fractio... | ['Adsorption', 'Biodegradation, Environmental', 'Hydrolysis', 'Lignin', 'Phenanthrenes', 'Pinus', 'Plant Bark', 'Polycyclic Aromatic Hydrocarbons', 'Pyrenes', 'Regression Analysis', 'Solutions', 'Temperature', 'Water Pollutants, Chemical'] | 20,578,284 | [['G01.030', 'G02.020'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['G02.380'], ['D05.750.078.562.180.515', 'D05.750.078.687', 'D20.538', 'D25.720.099.687', 'J01.637.051.720.099.687'], ['D02.455.426.559.847.723', 'D04.615.723'], ['B01.650.940.800.575.912.625.875.777'], ['A18.024.750.200'], ['D02.455.426.559.847',... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Isolation and characterization of Rhodobacter capsulatus mutants affected in cytochrome cbb3 oxidase activity. | The facultative phototrophic bacterium Rhodobacter capsulatus contains only one form of cytochrome (cyt) c oxidase, which has recently been identified as a cbb3-type cyt c oxidase. This is unlike other related species, such as Rhodobacter sphaeroides and Paracoccus denitrificans, which contain an additional mitochondri... | ['Bacterial Proteins', 'Chromosome Mapping', 'Electron Transport Complex IV', 'Genes, Bacterial', 'Genetic Complementation Test', 'Genomic Library', 'Molecular Sequence Data', 'Mutation', 'Operon', 'Oxidoreductases', 'Oxidoreductases, N-Demethylating', 'Rhodobacter capsulatus', 'Sequence Analysis, DNA', 'Species Specif... | 9,473,054 | [['D12.776.097'], ['E05.393.183'], ['D05.500.562.374', 'D08.811.600.250.687', 'D08.811.682.285', 'D12.776.157.530.450.250.875.304', 'D12.776.543.277.687', 'D12.776.543.585.450.250.875.484'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['E05.393.281.526'], ['G05.360.325.425', '... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Gene expression profile of renal proximal tubules regulated by proteinuria. | BACKGROUND: Proximal tubules activated by reabsorption of protein are thought to play significant roles in the progression of kidney diseases. Thus, identification of genes related to proteinuria should provide insights into the pathological process of tubulointerstitial fibrosis.METHOD: Gene expression profiles were c... | ['Amino Acid Sequence', 'Animals', 'Antigens, Ly', 'Avian Proteins', 'Base Sequence', 'Chromosome Mapping', 'Disease Models, Animal', 'Female', 'Gene Expression Profiling', 'Humans', 'Kidney Tubules, Proximal', 'Lipoproteins', 'Male', 'Membrane Proteins', 'Mice', 'Mice, Inbred C57BL', 'Molecular Sequence Data', 'Nephri... | 11,967,007 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D23.050.301.264.920', 'D23.101.100.920'], ['D12.776.095'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.45... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The presence of free G protein beta/gamma subunits in human neutrophils results in suppression of adenylate cyclase activity. | We have examined the adenylate cyclase of human neutrophil membranes and compared it to that of human platelet membranes. Stimulated activities were at least 20-fold lower in the neutrophil than in the human platelet. The inhibitory hormone epinephrine was able to attenuate markedly the adenylate cyclase activity of hu... | ['Adenylyl Cyclase Inhibitors', 'Adenylyl Cyclases', 'Animals', 'Blood Platelets', 'Cattle', 'Cell Membrane', 'Epinephrine', 'GTP-Binding Proteins', "Guanosine 5'-O-(3-Thiotriphosphate)", 'Guanosine Triphosphate', 'Humans', 'Macromolecular Substances', 'Neutrophils', 'Thionucleotides'] | 3,100,516 | [['D27.505.519.389.108'], ['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['A11.118.188', 'A15.145.229.188'], ['B01.050.150.900.649.313.500.380.271'], ['A11.284.149'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.46... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Targeting miRNA for Therapy of Juvenile and Adult Diabetic Cardiomyopathy. | Prevalence of diabetes mellitus (DM), a multifactorial disease often diagnosed with high blood glucose levels, is rapidly increasing in the world. Association of DM with multi-organ dysfunction including cardiomyopathy makes it a leading cause of morbidity and mortality. There are two major types of DM: type 1 DM (T1D)... | ['Adult', 'Child', 'Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 2', 'Diabetic Cardiomyopathies', 'Exosomes', 'Fibrosis', 'Gene Expression Regulation', 'Humans', 'Inflammation', 'Insulin Resistance', 'MicroRNAs', 'Molecular Targeted Therapy', 'Myocardium', 'Myocytes, Cardiac', 'Oxidative Stress', 'RNA Interfere... | 29,754,174 | [['M01.060.116'], ['M01.060.406'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C18.452.394.750.149', 'C19.246.300'], ['C14.280.238.235', 'C19.246.099.625'], ['A11.284.295.588.750', 'A11.284.430.214.190.875.190.880.495'], ['C23.550.355'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.5... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Genetic defect in biosynthesis of the precursor form of the fourth component of complement. | Under cell-free conditions, liver polysomes from guinea pigs genetically deficient in the fourth component of complement (C4) did not synthesize pro-C4 (the precursor of C4), but did synthesize nascent C4 polypeptides which remained polysome bound. The defect was specific for pro-C4 synthesis since the amounts of total... | ['Animals', 'Cell-Free System', 'Complement C4', 'Guinea Pigs', 'Immunoprecipitation', 'Liver', 'Polyribosomes', 'Protein Biosynthesis', 'RNA, Messenger'] | 17,569,484 | [['B01.050'], ['A11.284.835.168'], ['D12.776.124.486.274.350'], ['B01.050.150.900.649.313.992.550'], ['E05.196.150.639', 'E05.478.605'], ['A03.620'], ['A11.284.430.214.190.875.811.740'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['D13.444.735.544']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Potential use of folate-polyethylene glycol (PEG)-appended dendrimer (G3) conjugate with á-cyclodextrin as DNA carriers to tumor cells. | We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with á-cyclodextrin (á-CyD) having an average degree of substitution of 2.4 of á-CyD (á-CDE) provided remarkable aspects as novel carriers for DNA and small-interfering RNA. To develop novel á-CDE derivatives with tu... | ['Animals', 'DNA', 'Dendrimers', 'Folic Acid', 'Gene Transfer Techniques', 'Humans', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Microscopy, Confocal', 'Polyamines', 'Transfection', 'alpha-Cyclodextrins'] | 22,402,627 | [['B01.050'], ['D13.444.308'], ['D05.750.327', 'E02.319.300.380.200', 'J01.637.512.600.200'], ['D03.633.100.733.631.400'], ['E05.393.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Revised estimates of enterococcal chromosomal sizes. | We previously reported that the chromosomal sizes of four strains of enterococci ranged from 2,045 to 2,761 kb. Extensive analysis and mapping subsequently confirmed the size of Enterococcus faecalis strain OG1 as 2,825 kb (prior size estimate range, 2,750-2,761 kb) (Murray et al., J. Bacteriol. 175, 5216, 1993). Howev... | ['Chromosomes, Bacterial', 'DNA, Bacterial', 'Enterococcus faecalis', 'Enterococcus faecium', 'Molecular Weight', 'Restriction Mapping', 'Species Specificity'] | 7,702,757 | [['A11.284.187.190', 'A20.812', 'G05.360.162.190'], ['D13.444.308.212'], ['B03.353.750.250.250.280', 'B03.510.550.250.250.280'], ['B03.353.750.250.250.300', 'B03.510.550.250.250.300'], ['G02.494'], ['E05.393.183.620.650', 'E05.393.712'], ['G16.824']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improved thin-layer chromatography bioautographic assay for the detection of actylcholinesterase inhibitors in plants. | INTRODUCTION: Thin-layer chromatography (TLC) bioautographic method is a simple and rapid method to screen acetylcholinesterase inhibitors from plant extracts. However, the high consumption of enzyme (6 U/mL) in current methods makes the procedure expensive, which is an obstacle to scientific research centers lacking f... | ['Acetylation', 'Alkaloids', 'Anisoles', 'Chlorides', 'Cholinesterase Inhibitors', 'Chromatography, High Pressure Liquid', 'Chromatography, Thin Layer', 'Chromogenic Compounds', 'Color', 'Enzyme Assays', 'Ferric Compounds', 'Ferricyanides', 'Hydrolysis', 'Limit of Detection', 'Molecular Structure', 'Phellodendron', 'Ph... | 21,433,160 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['D03.132'], ['D02.355.601.200', 'D02.355.726.158', 'D02.455.426.559.389.657.654.158'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['E05.196.181.400.300'], ['E05.196.181.400.537'], ['D... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Secular trends in body mass index and skinfold thickness with socioeconomic factors in young adult men. | Secular trends in the relationship of body mass index (BMI) and skinfold thickness to educational and income levels were examined for white and black men aged 18-34 y over the period 1960-80 with data from three successive national surveys: NHES Cycle I, NHANES I, and NHANES II. Statistical models were fitted to assess... | ['Adult', 'African Americans', 'Body Height', 'Body Weight', 'Educational Status', 'European Continental Ancestry Group', 'Health Surveys', 'Humans', 'Male', 'Skinfold Thickness', 'Socioeconomic Factors', 'Statistics as Topic', 'United States'] | 3,414,569 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['N01.824.196'], ['M01.686.508.400'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Attention during natural vision warps semantic representation across the human brain. | Little is known about how attention changes the cortical representation of sensory information in humans. On the basis of neurophysiological evidence, we hypothesized that attention causes tuning changes to expand the representation of attended stimuli at the cost of unattended stimuli. To investigate this issue, we us... | ['Adult', 'Attention', 'Brain Mapping', 'Cerebral Cortex', 'Concept Formation', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Motion Pictures', 'Neuropsychological Tests', 'Semantics', 'Visual Perception'] | 23,603,707 | [['M01.060.116'], ['F02.830.104.214'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['F02.463.785.233'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['J01.897.280.500.598', 'K01.093.545', 'L01.178.590.500', 'L01.178.820.090.598... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Humanities [K]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
[Clinical study of noise-induced deafness. Part 12: Results of tests on cases of tinnitus and evaluation]. | For 80 cases of noise-induced deafness, various tests on tinnitus were performed to obtain results as follows. 1) When tinnitus was analyzed by the tinnitus questionnaire, many had bilateral tinnitus all the time, while few noted changes in the tone and loudness of sound. 2) As for the tinnitus frequency obtained by th... | ['Aged', 'Hearing Loss, Noise-Induced', 'Hearing Tests', 'Humans', 'Male', 'Middle Aged', 'Tinnitus'] | 2,376,790 | [['M01.060.116.100'], ['C09.218.458.341.887.460', 'C10.597.751.418.341.887.460', 'C23.888.592.763.393.341.887.460'], ['E01.370.382.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C09.218.458.670', 'C10.597.751.418.670', 'C23.888.592.763.393.670']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Differential acute-phase response of rat kininogen genes involves type I and type II interleukin-6 response elements. | The serum concentration of rat T1 kininogen increases 20-30-fold in response to acute inflammation. This increase, induced in the liver, is regulated primarily at the transcriptional level. In contrast, synthesis of a homologous K kininogen is not induced. In this study, we further analyzed a 321-base pair interleukin ... | ['Animals', 'Base Sequence', 'Binding Sites', 'CCAAT-Enhancer-Binding Protein-delta', 'CCAAT-Enhancer-Binding Proteins', 'Cell Line', 'DNA-Binding Proteins', 'Dexamethasone', 'Exons', 'Gene Expression Regulation', 'Humans', 'Interleukin-6', 'Kininogens', 'Molecular Sequence Data', 'Nuclear Proteins', 'Oligodeoxyribonuc... | 8,244,962 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D12.776.260.108.124.812', 'D12.776.660.167.812', 'D12.776.930.127.124.812'], ['D12.776.260.108.124', 'D12.776.660.167', 'D12.776.930.127.124'], ['A11.251.210'], ['D12.776.260'], ['D04.210.500.745.432.769.344', 'D04.210.500.9... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Surgical management of trigeminal schwannomas: defining the role for endoscopic endonasal approaches. | OBJECT: Because multiple anatomical compartments are involved, the surgical management of trigeminal schwannomas requires a spectrum of cranial base approaches. The endoscopic endonasal approach to Meckel's cave provides a minimal access corridor for surgery, but few reports have assessed outcomes of the procedure or p... | ['Adult', 'Cranial Nerve Neoplasms', 'Endoscopy', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neurilemmoma', 'Nose', 'Prospective Studies', 'Retrospective Studies', 'Trigeminal Nerve'] | 25,270,136 | [['M01.060.116'], ['C04.588.614.300', 'C04.588.614.596.240', 'C10.292.225', 'C10.551.360', 'C10.551.775.250'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C04.557.465.625.650.595', 'C04.557.580.600.610.595', 'C04.557.580.625.650.59... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transcriptional activation of the human immunodeficiency virus long terminal repeat sequences by tumor necrosis factor. | The recombinant plasmid pBHIV-1 carrying the long terminal repeat (LTR) of the human immunodeficiency virus 1 (HIV-1), linked to the reported chloramphenicol acetyl transferase (CAT) gene, was introduced into human and rat fibroblasts. Stable transfectants were obtained which were resistant to genetecin and expressed C... | ['Animals', 'Cell Line', 'Chloramphenicol O-Acetyltransferase', 'Dose-Response Relationship, Drug', 'Gentamicins', 'HIV Long Terminal Repeat', 'HIV-1', 'Humans', 'Kinetics', 'Rats', 'Recombinant Proteins', 'Transcription, Genetic', 'Transcriptional Activation', 'Transfection', 'Tumor Necrosis Factor-alpha'] | 1,295,450 | [['B01.050'], ['A11.251.210'], ['D08.811.913.050.134.170'], ['G07.690.773.875', 'G07.690.936.500'], ['D09.408.051.374'], ['G02.111.570.080.708.850.400', 'G05.360.080.708.850.400'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['B01.050.150.900.649.313... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lingual nerve injury during suspension microlaryngoscopy. | Lingual nerve injury is an uncommon complication of laryngoscopy. We report a case of isolated unilateral lingual nerve injury that occurred during suspension microlaryngoscopy. The injury was transient, with complete return of sensation within 3 months after surgery. Several mechanisms have been proposed to explain th... | ['Adult', 'Cysts', 'Humans', 'Laryngeal Diseases', 'Laryngoscopes', 'Lingual Nerve Injuries', 'Male', 'Nerve Compression Syndromes', 'Postoperative Complications', 'Risk Factors', 'Tongue', 'Vocal Cords'] | 10,807,339 | [['M01.060.116'], ['C04.182', 'C23.300.306'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.360', 'C09.400'], ['E07.230.220.525', 'E07.858.240.525'], ['C07.465.299.625.500.349.500', 'C10.292.200.875.500', 'C10.292.319.625.700.349.500', 'C10.900.300.218.775.500', 'C26.915.300.400.825.500'], ['C10.668.829.550'],... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Disulfide between Cys392 and Cys438 of human serum albumin is redox-active, which is responsible for the thioredoxin-supported lipid peroxidase activity. | Human serum albumin (HSA) is an abundant protein found in blood plasma and extracellular fluids. Previously, we found that HSA has a distinct thioredoxin (Trx)-dependent lipid peroxidase activity in the presence of palmitoyl-CoA. In this paper, we identified the redox-active disulfide, which can be specifically reduced... | ['Binding Sites', 'Catalysis', 'Cysteine', 'Disulfides', 'Humans', 'Lipid Peroxidation', 'Oxidation-Reduction', 'Peptide Fragments', 'Peroxidases', 'Serum Albumin', 'Thioredoxins'] | 16,343,416 | [['G02.111.570.120'], ['G02.130'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.515', 'G03.295.531.587'], ['G02.700', 'G03.295.531'], ['D12.644.541'], ['D08.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel bioactive porous bredigite (Ca7MgSi4O16) scaffold with biomimetic apatite layer for bone tissue engineering. | The aim of this study was to develop a novel bioactive, degradable and cytocompatible bredigite (Ca(7)MgSi(4)O(16)) scaffold with biomimetic apatite layer for bone tissue engineering. Porous bredigite scaffolds were prepared using polymer sponge method. The bredigite scaffolds with biomimetic apatite layer (BTAP) were ... | ['Absorbable Implants', 'Animals', 'Apatites', 'Asbestos, Amphibole', 'Biocompatible Materials', 'Biomimetic Materials', 'Body Fluids', 'Calcium Phosphates', 'Cell Differentiation', 'Cell Proliferation', 'Cells, Cultured', 'Materials Testing', 'Microscopy, Electron, Scanning', 'Osteoblasts', 'Rats', 'Spectrophotometry,... | 17,211,720 | [['E07.695.025'], ['B01.050'], ['D01.029.260.700.675.374.075.025', 'D01.146.360.050', 'D01.578.122', 'D01.695.625.675.650.075.025'], ['D01.578.725.050.050', 'D01.837.725.700.760.070.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['J01.637.087'], ['A12.207'], ['D01.029.260.700.675.374.075', 'D01.146.360', 'D0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Expressed Emotion, Family Functioning, and Treatment Outcome for Adolescents with Anorexia Nervosa. | The current study examined the relation between parental expressed emotion (EE) and treatment outcome among adolescents participating in a treatment study for adolescent anorexia nervosa, as well as its impact on family functioning. One hundred and twenty-one families were assigned to family-based treatment or adolesce... | ['Adolescent', 'Anorexia Nervosa', 'Child', 'Expressed Emotion', 'Family Therapy', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Parent-Child Relations', 'Parents', 'Treatment Outcome'] | 26,201,083 | [['M01.060.057'], ['F03.400.125'], ['M01.060.406'], ['F01.829.197'], ['F04.754.864.581.273'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.290'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620']... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Current status of treatment of type 2 diabetes mellitus in Ningbo, China. | BACKGROUND: The treatment status of type 2 diabetes mellitus (T2DM) in Ningbo has not been reported in the past. To evaluate the current status of T2DM in Ningbo and provide evidence to formulate more policies, a multicenter investigation was needed.METHODS: The Ningbo Clinical Research Group of Diabetes constituted ni... | ['Aged', 'Blood Glucose', 'China', 'Diabetes Mellitus, Type 2', 'Dyslipidemias', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Overweight', 'Prevalence', 'Treatment Outcome'] | 30,461,061 | [['M01.060.116.100'], ['D09.947.875.359.448.500'], ['Z01.252.474.164'], ['C18.452.394.750.149', 'C19.246.300'], ['C18.452.584.500'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381', 'D12.776.422.316.762.380.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
CD52 expression in peripheral T-cell lymphomas determined by combined immunophenotyping using tumor cell specific T-cell receptor antibodies. | For peripheral T-cell lymphomas (PTCL), anti-CD52 (alemtuzumab) therapy is currently under investigation. Previous studies reported widely divergent CD52 expression within PTCL using conventional immunohistochemistry. To accurately discriminate between the presumed mechanistically relevant CD52 expression in tumor vers... | ['Antibodies', 'Antigens, CD', 'Antigens, Neoplasm', 'CD52 Antigen', 'Fluorescent Antibody Technique', 'Glycoproteins', 'Humans', 'Immunophenotyping', 'Ki-1 Antigen', 'Lymphoma, Large-Cell, Anaplastic', 'Lymphoma, T-Cell, Peripheral', 'Receptors, Antigen, T-Cell, alpha-beta'] | 19,479,612 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.285'], ['D12.776.395.550.448.190', 'D12.776.543.484.500.190', 'D12.776.543.550.418.190', 'D23.050.285.022', 'D23.101.100.943'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.5... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Safe high-pressure freezing of infectious micro-organisms. | We describe how high-pressure freezing of infectious biological material can safely be accomplished with the help of membrane carriers. The method described is easy to perform; however, careful manipulations are required. Existing safety regulations must still be followed. However, the procedure reduces the risk of dis... | ['Containment of Biohazards', 'Cryopreservation', 'Equipment Safety', 'Humans', 'Hydrostatic Pressure', 'Microscopy, Electron', 'Streptococcus pneumoniae'] | 22,364,646 | [['E05.235', 'N06.850.135.060.075.249'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['E05.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.715.352'], ['E01.370.350.515.402', 'E05.595.402'], ['B03.35... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Sirolimus-eluting stents versus bare-metal stents in routine clinical use: a nonrandomized comparison. | Conflicting patient outcomes have been reported after the use of sirolimus-eluting stents or bare-metal stents. In this nonrandomized study, we examine the outcomes after placement of sirolimus-eluting versus bare-metal stents in an unselected population of patients who underwent percutaneous coronary revascularization... | ['Aged', 'Angioplasty, Balloon, Coronary', 'Cardiovascular Agents', 'Cerebrovascular Disorders', 'Chi-Square Distribution', 'Coronary Artery Disease', 'Drug-Eluting Stents', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Logistic Models', 'Male', 'Metals', 'Middle Aged', 'Myocardial Infarction', 'Patient Selection', 'Pr... | 22,163,124 | [['M01.060.116.100'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['D27.505.954.411'], ['C10.228.140.300', 'C14.907.253'], ['E05.318.740.994.300', 'G17.820.300', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Pharmacophore search for anti-fertility and estrogenic potencies of estrogen analogs. | Estrogen mediates its action following binding to the estrogen receptor to form an estrogen-receptor complex. The complex initiates gene transcription and produces estrogen-induced cell and/or tissue responses, i.e., estrogenic actions. High doses of estrogen can be used effectively as a contraceptive but are associate... | ['Contraceptive Agents', 'Drug Design', 'Estradiol Congeners', 'Estrogens', 'Hydrogen Bonding', 'Models, Molecular', 'Molecular Structure', 'Quantitative Structure-Activity Relationship'] | 18,663,492 | [['D27.505.696.875.360', 'D27.505.954.705.360'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D06.472.334.851.437'], ['D27.505.696.399.472.277'], ['G02.282'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['G02.111.830.500', 'G07.690.773.997.500']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Taste-to-postingestive consequence conditioning: is the rise in sham feeding with repeated experience a learning phenomenon? | Although the progressive increase in intake with repeated sham feeding experience is assumed to reflect the extinction of learned satiety, the involvement of associative learning in this phenomenon has never been directly demonstrated. We show that: a) animals attenuate sham feeding on initial exposure only with foods ... | ['Animals', 'Behavior, Animal', 'Conditioning, Classical', 'Feeding Behavior', 'Inhibition, Psychological', 'Learning', 'Male', 'Rats', 'Taste'] | 2,756,038 | [['B01.050'], ['F01.145.113'], ['F02.463.425.179.308'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['F01.145.544', 'F02.463.425.475', 'F02.739.794.405'], ['F02.463.425', 'F02.784.629.529'], ['B01.050.150.900.649.313.992.635.505.700'], ['F02.830.816.724', 'G11.561.790.724']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Phenotypic changes of mast cells during hepatocarcinogenesis in rats]. | Sequential observation was made to detect the phenotypic change of mast cells during the process of dimethylaminoazobenzene-induced hepatocarcinogenesis in rats by cytochemistry, immunocytochemistry and electron microscopy. The number of mast cells in the liver tissues increased in various extent 4 weeks following the ... | ['Animals', 'Liver', 'Liver Neoplasms, Experimental', 'Male', 'Mast Cells', 'Phenotype', 'Rats', 'Rats, Sprague-Dawley', 'p-Dimethylaminoazobenzene'] | 1,477,939 | [['B01.050'], ['A03.620'], ['C04.588.274.623.460', 'C04.619.540', 'C06.301.623.460', 'C06.552.697.580', 'E05.598.500.496.750'], ['A11.329.427', 'A15.382.652'], ['G05.695'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D02.092.146.325']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Risk, severity and predictors of physical and psychological morbidity after axillary lymph node dissection for breast cancer. | The aim of this study was to investigate the nature and severity of the arm complaints among breast cancer patients after axillary lymph node dissection (ALND) and to study the effects of this treatment-related morbidity on daily life and well-being. 400 women, who underwent ALND as part of breast cancer surgery, fille... | ['Activities of Daily Living', 'Adult', 'Aged', 'Anxiety', 'Arm', 'Axilla', 'Breast Neoplasms', 'Female', 'Humans', 'Lymph Node Excision', 'Lymphedema', 'Middle Aged', 'Musculoskeletal Diseases', 'Pain', 'Quality of Life', 'Risk Factors', 'Surveys and Questionnaires'] | 11,334,724 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116'], ['M01.060.116.100'], ['F01.470.132'], ['A01.378.800.075'], ['A01.378.800.090'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.446'], ['C15.604.496'], ['M01.060.116.630'], ['C05'], ['C... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Humanities [K]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons. | Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons. J. Neurophysiol. 78: 2790-2794, 1997. To better understand the neuronal mechanism of neuropathic pain, the effect of axotomy on the excitability of dorsal root ganglion (DRG) cells with unmyelinated axons (C cells) was investigate... | ['Animals', 'Animals, Newborn', 'Axons', 'Axotomy', 'Ganglia, Spinal', 'In Vitro Techniques', 'Nerve Fibers, Myelinated', 'Neural Conduction', 'Neurons', 'Patch-Clamp Techniques', 'Rats', 'Rats, Sprague-Dawley', 'Reaction Time', 'Sciatic Nerve', 'Sodium Channels', 'Tetrodotoxin'] | 9,356,426 | [['B01.050'], ['B01.050.050.282'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['E04.525.210.158'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['E05.481'], ['A08.675.542.512', 'A11.671.501.512', 'A11.671.514'], ['G07.265.753', 'G11.561.601'], ['A08.675', 'A11.671'],... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of UV-induced squamous cell carcinomas is suppressed in the absence of SPARC. | SPARC (Secreted Protein Acidic and Rich in Cysteine) is a multifunctional glycoprotein belonging to a group of matrix-associated factors that mediate cell-extracellular matrix interactions but have no structural roles. In the present study we investigated the contribution of SPARC to factors that influence the developm... | ['Animals', 'Carcinoma, Squamous Cell', 'Dermatitis, Contact', 'Extracellular Matrix Proteins', 'Female', 'Hyperplasia', 'Male', 'Mice', 'Mice, Hairless', 'Mice, Inbred C57BL', 'Mice, Mutant Strains', 'Neoplasms, Radiation-Induced', 'Neovascularization, Pathologic', 'Osteonectin', 'Skin', 'Skin Neoplasms', 'Transformin... | 15,304,102 | [['B01.050'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C17.800.174.255', 'C17.800.815.255'], ['D12.776.860.300'], ['C23.550.444'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.200', 'B01.050.150.900.649.313.992.635.505.500.400.200', 'B01.050.150.900.649.313.992.635.505.500.550.230'], ... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Sequence-independent amplification and cloning of large dsRNA virus genome segments by poly(dA)-oligonucleotide ligation. | A strategy was developed for sequence-independent synthesis and amplification of full-length cDNA of 3-4 kb genes of dsRNA viruses. The method of single primer amplification (Lambden et al., 1992) was adapted by the inclusion of a 3' poly(A) tail to an oligonucleotide ligated to dsRNA genome segments as a template for ... | ['African Horse Sickness Virus', 'Animals', 'Blotting, Northern', 'DNA Primers', 'DNA, Complementary', 'Electrophoresis, Agar Gel', 'Gene Amplification', 'Genome, Viral', 'Horses', 'RNA Viruses'] | 9,694,332 | [['B04.820.223.719.550.050'], ['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['E05.196.401.153', 'E05.301.300.100'], ['G05.308.250', 'G05.365.590.310', 'G05.558... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Postoperative pain management in pediatric patients undergoing minimally invasive repair of pectus excavatum: the role of intercostal block. | PURPOSE: There are no published data regarding value of intercostal block following pectus excavatum repair. Our aim was to evaluate the efficacy of intercostal block in children following minimally invasive repair of pectus excavatum (MIRPE).METHODS: Forty-five patients given patient-controlled analgesia (PCA) with mo... | ['Adolescent', 'Analgesia, Patient-Controlled', 'Analgesics, Opioid', 'Anesthetics, Local', 'Bupivacaine', 'Child', 'Drug Administration Schedule', 'Drug Therapy, Combination', 'Epinephrine', 'Female', 'Follow-Up Studies', 'Funnel Chest', 'Humans', 'Linear Models', 'Male', 'Minimally Invasive Surgical Procedures', 'Mor... | 24,314,181 | [['M01.060.057'], ['E03.091.120'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['D02.065.199.239', 'D02.092.146.113.239'], ['M01.060.406'], ['E02.319.2... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Contractile properties of the cultured vascular smooth muscle cells: the crucial role played by RhoA in the regulation of contractility. | Vascular smooth muscle cells (VSMCs) have a remarkable degree of plasticity and in response to vascular injury, they can change to a dedifferentiated state that can be typically seen in cell cultures. Recently, Y27632, a Rho kinase inhibitor, has been reported to preferentially correct hypertension in a hypertensive ra... | ['Amides', 'Animals', 'Calcium', 'Cells, Cultured', "Guanosine 5'-O-(3-Thiotriphosphate)", 'Muscle, Smooth, Vascular', 'Myocytes, Smooth Muscle', 'Myosin Light Chains', 'Phosphorylation', 'Protein Kinase C', 'Pyridines', 'RNA Interference', 'Swine', 'Vasoconstriction', 'rhoA GTP-Binding Protein'] | 15,774,857 | [['D02.065'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251'], ['D02.886.765.380', 'D13.695.667.454.504.380', 'D13.695.827.426.504.380', 'D13.695.900.380'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.467.491'], ['A11.620.520'], ['D05.750.078.730.475.200', 'D12.776.157.125.475', 'D12... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Carbamazepine but not valproate induces CYP2A6 activity in smokers with mental illness. | BACKGROUND: Antiepileptic drugs (AED) are being increasingly used in the management of serious mental illness, but their effects on nicotine metabolism have not been studied.METHODS: This study investigated the effects of three AEDs (carbamazepine, oxcarbazepine, and valproic acid) on nicotine and nicotine metabolite l... | ['Adult', 'Anticonvulsants', 'Aryl Hydrocarbon Hydroxylases', 'Bipolar Disorder', 'Carbamazepine', 'Cotinine', 'Cytochrome P-450 CYP2A6', 'Enzyme Induction', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nicotine', 'Oxcarbazepine', 'Schizophrenia', 'Smoking', 'Valproic Acid', 'Young Adult'] | 20,719,908 | [['M01.060.116'], ['D27.505.954.427.080'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['F03.084.500'], ['D03.633.300.240.127'], ['D03.383.773.812.180'], ['D08.244.453.491.250', 'D08.811.682.690.708.170.450.250', 'D12.776.422.220.453.491.250'], ['G05.308.320.200'], ['B01.050.150.900.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Effects of ischemia on peripheral nerve evoked potential. Experimental and clinical study]. | The association between impaired circulation and peripheral nerve disorders has been recognized for many years. Although many experimental and clinical studies have been carried out on the "ischemic neuropathy", the routine examination to certify it may have not yet been established. Peripheral nerve evoked potential m... | ['Adolescent', 'Adult', 'Animals', 'Arterial Occlusive Diseases', 'Cats', 'Diabetes Mellitus', 'Evoked Potentials', 'Female', 'Humans', 'Ischemia', 'Male', 'Median Nerve', 'Middle Aged', 'Peripheral Nerves'] | 6,470,540 | [['M01.060.057'], ['M01.060.116'], ['B01.050'], ['C14.907.137'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['C18.452.394.750', 'C19.246'], ['G07.265.216.500', 'G11.561.200.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.513'], ['A08.800.800.720.050.500'], ['M01.060.116.630'], ['A08.800.800']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of dietary intervention and lipid-lowering treatment on brachial vasoreactivity in patients with ischemic heart disease and hypercholesterolemia. | BACKGROUND: The "Mediterranean" diet and statin treatment have both independently been shown to improve survival and reduce the risk of cardiovascular events in patients with ischemic heart disease (IHD), but no studies have evaluated the effect of this combination on endothelial function. We therefore sought to evalua... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Brachial Artery', 'Cholesterol', 'Cholesterol, LDL', 'Combined Modality Therapy', 'Diet, Mediterranean', 'Endothelium, Vascular', 'Fatty Acids, Monounsaturated', 'Female', 'Fluvastatin', 'Humans', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Indoles', 'Male', ... | 12,766,751 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.015.114.139'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'], ['E02.186'], ['E02.642.249.270', 'G07.203.650... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Brain death with calcium oxalate deposition in the kidney: clue to the diagnosis of ethylene glycol poisoning. | A young man presented to the emergency department with mental status changes, severe metabolic acidosis, and oliguria. Acute ethylene glycol intoxication was diagnosed. The patient suffered clinical brain death three days after admission despite intensive care and continuous hemodiafiltration. The patient died one mont... | ['Adult', 'Brain', 'Brain Death', 'Calcium Oxalate', 'Ethylene Glycol', 'Forensic Pathology', 'Humans', 'Kidney', 'Kidney Cortex Necrosis', 'Male', 'Meningoencephalitis', 'Poisoning', 'Sinus Thrombosis, Intracranial'] | 17,697,792 | [['M01.060.116'], ['A08.186.211'], ['C10.228.140.151', 'C10.597.606.358.800.200.100', 'C23.550.260.159'], ['D02.241.081.337.593.750.500'], ['D02.033.455.250.268'], ['H02.403.330.300', 'H02.403.650.249', 'I01.198.780.937.460'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419.393', 'C13.35... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
Systemic Venous Rerouting Through the Coronary Sinus for ccTGA With Bilateral SVCs. | The double-switch operation for congenitally corrected transposition of the great arteries, in which the morphologic left ventricle is restored to the systemic circulation, is an effective surgical option. This case report describes an atrial switch technique without using supplemental material during the double-switch... | ['Abnormalities, Multiple', 'Arterial Switch Operation', 'Cardiac Catheterization', 'Combined Modality Therapy', 'Computed Tomography Angiography', 'Coronary Sinus', 'Follow-Up Studies', 'Heart Defects, Congenital', 'Heart Septal Defects, Atrial', 'Humans', 'Imaging, Three-Dimensional', 'Infant', 'Male', 'Rare Diseases... | 29,054,237 | [['C16.131.077'], ['E04.100.376.031', 'E04.928.220.055'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E02.186'], ['E01.370.350.350.810.335', 'E01.370.350.567.250', 'E01.370.350.600.350.700.810.335', 'E01.370.350.700.700.810.335', 'E01.370.350.700.810.810.568', 'E01.370.350.825.810.810.499'], ['A07.015.908.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Quantitative determination of Plasmodium parasitemia by flow cytometry and microscopy. | The traditional light microscopy has limitations for precise growth assays of malaria parasites in culture or for assessment of new compounds for antimalarial activity; the speed and high reproducibility of flow cytometry can overcome these limitations. A flow cytometric method using PicoGreen, a DNA-binding fluorochro... | ['Flow Cytometry', 'Fluorescent Dyes', 'Humans', 'Microscopy', 'Organic Chemicals', 'Parasitemia', 'Plasmodium falciparum', 'Reproducibility of Results', 'Ribonucleases', 'Signal-To-Noise Ratio'] | 23,091,308 | [['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
CANDI: an R package and Shiny app for annotating radiographs and evaluating computer-aided diagnosis. | MOTIVATION: Radiologists have used algorithms for Computer-Aided Diagnosis (CAD) for decades. These algorithms use machine learning with engineered features, and there have been mixed findings on whether they improve radiologists' interpretations. Deep learning offers superior performance but requires more training dat... | ['Algorithms', 'Deep Learning', 'Humans', 'Machine Learning', 'Neural Networks, Computer', 'Software'] | 30,304,439 | [['G17.035', 'L01.224.050'], ['G17.035.250.500.250', 'G17.485.500', 'L01.224.050.375.530.250', 'L01.224.050.375.605.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G17.035.250.500', 'L01.224.050.375.530'], ['G17.485', 'L01.224.050.375.605'], ['L01.224.900']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages. | Lipin-2 is a member of the lipin family of enzymes, which are key effectors in the biosynthesis of lipids. Mutations in the human lipin-2 gene are associated with inflammatory-based disorders; however, the role of lipin-2 in cells of the immune system remains obscure. In this study, we have investigated the role of lip... | ['Animals', 'Cell Line', 'Cytokines', 'Enzyme Activation', 'Fatty Acids', 'Humans', 'Inflammation', 'JNK Mitogen-Activated Protein Kinases', 'Macrophages', 'Mice', 'Monocytes', 'Nuclear Proteins', 'Phosphatidate Phosphatase', 'Signal Transduction', 'Transcription Factor AP-1', 'Triglycerides', 'Up-Regulation'] | 22,334,674 | [['B01.050'], ['A11.251.210'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G02.111.263', 'G03.328'], ['D10.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['D08.811.913.696.620.682.700.567.374', 'D12.644.360.450.340', 'D12.776.476.450.340'], ['A11.329.372', 'A11.627.482', 'A11.733.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Catechin metabolism: glutathione conjugate formation catalyzed by tyrosinase, peroxidase, and cytochrome p450. | The metabolic pathways of dietary flavonoids are still largely unknown. In the present work, mass spectrometry and UV-vis spectroscopy studies were used to show that the naturally occurring flavonoid catechin underwent enzymatic oxidation by tyrosinase in the presence of glutathione (GSH) to form mono-, bi-, and tri-gl... | ['Animals', 'Catalysis', 'Catechin', 'Cytochrome P-450 Enzyme System', 'Glutathione', 'Hepatocytes', 'Magnetic Resonance Spectroscopy', 'Male', 'Microsomes, Liver', 'Models, Molecular', 'Monophenol Monooxygenase', 'Oxidation-Reduction', 'Peroxidase', 'Polymers', 'Rats', 'Rats, Sprague-Dawley'] | 11,453,730 | [['B01.050'], ['G02.130'], ['D03.383.663.283.240.190', 'D03.383.663.283.266.450.206', 'D03.633.100.150.240.190', 'D03.633.100.150.266.450.206'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['D12.644.456.448'], ['A11.436.348'], ['E05.196.867.519'], ['A11.284.835.540.541'], ['E05.599.595'], ['D08.8... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
An interesting case of bilateral bifid insertion of superior rectus muscle as an intra-operative finding in a patient with oculocutaneous albinism. | We report a case of bilateral bifid insertion of superior rectus muscles, in a patient with oculocutaneous albinism as an incidental intraoperative finding during eye muscle surgery. The muscle was successfully operated on and the patient did well postoperatively. To our knowledge, this is the first report of this anom... | ['Albinism, Oculocutaneous', 'Child', 'Female', 'Follow-Up Studies', 'Humans', 'Incidental Findings', 'Intraoperative Period', 'Oculomotor Muscles'] | 23,975,092 | [['C11.270.040.545', 'C16.320.290.040.100', 'C16.320.565.100.102.100', 'C16.320.850.080.100', 'C17.800.621.440.102.100', 'C17.800.827.080.100', 'C18.452.648.100.102.100'], ['M01.060.406'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.40... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Preoperative radiographic assessment of hepatic steatosis with histologic correlation. | BACKGROUND: The adverse impact of hepatic steatosis on perioperative outcomes after liver resection is gaining recognition. But the accuracy of preoperative radiologic assessment of fatty liver disease remains unclear. The objective of this study was to correlate preoperative radiologic estimation with postoperative hi... | ['Aged', 'Body Mass Index', 'Contrast Media', 'Fatty Liver', 'Female', 'Hepatectomy', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Reproducibility of Results', 'Retrospective Studies', 'Tomography, X-Ray Computed'] | 18,308,219 | [['M01.060.116.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D27.505.259.500', 'D27.720.259'], ['C06.552.241'], ['E04.210.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E05.318.370.800.650', 'N05.715.360.32... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Morningness/eveningness and the need for sleep. | The purpose of this study was to determine, in a large sample of adults of all ages (17-80 years), the effect of morningness/eveningness on sleep/wake schedules, sleep needs, sleep hygiene and subjective daytime somnolence. A total of 617 subjects (219 subjects per chronotype group) matched for age, sex and employment ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Automobile Driving', 'Chronobiology Phenomena', 'Circadian Rhythm', 'Disorders of Excessive Somnolence', 'Female', 'Humans', 'Male', 'Middle Aged', 'Sleep', 'Sleep Deprivation', 'Surveys and Questionnaires', 'Wakefulness'] | 10,646,169 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['I03.125'], ['G07.180'], ['G07.180.562.190'], ['C10.886.425.800.200', 'F03.870.400.800.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F02.830.855', 'G11.561.803'], ['C10.886.425.175', 'C23.888.592.796.772',... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Changes in brain metabolites related to stress resilience: Metabolomic analysis of the hippocampus in a rat model of depression. | The ability to cope successfully with stress is known as 'resilience', and those with resilience are not prone to developing depression. One preclinical animal model for depression is the chronic mild stress (CMS) model. There are CMS-resilient (do not manifest anhedonia) and CMS-susceptible (manifest anhedonia) rats. ... | ['Anhedonia', 'Animals', 'Aspartic Acid', 'Biomarkers', 'Brain-Derived Neurotrophic Factor', 'Depressive Disorder', 'Dietary Sucrose', 'Disease Models, Animal', 'Disease Susceptibility', 'Food Preferences', 'Hippocampus', 'Male', 'Metabolomics', 'Motor Activity', 'Rats, Wistar', 'Resilience, Psychological', 'Stress, Ps... | 30,447,240 | [['C10.597.606.057', 'C23.888.592.604.039', 'F01.700.039'], ['B01.050'], ['D12.125.067.500', 'D12.125.119.170', 'D12.125.427.040'], ['D23.101'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['F03.600.300'], ['D09.301.831.250', 'D09.698.629.305.770.200', 'D09.947.500.250', 'D... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Perirenal hemorrhage as first presentation of Wilms tumor. | Wilms tumor typically presents as an abdominal mass, though occasionally patients present with other manifestations. We report a case of a child presenting with a perirenal hemorrhage and an initially occult Wilms tumor, found only on subsequent renal arteriography. Symptoms in this patient were caused by the presence ... | ['Angiography', 'Child, Preschool', 'Diagnosis, Differential', 'Female', 'Hemorrhage', 'Humans', 'Kidney Neoplasms', 'Tomography, X-Ray Computed', 'Ultrasonography', 'Wilms Tumor'] | 16,770,676 | [['E01.370.350.700.060', 'E01.370.370.050'], ['M01.060.406.448'], ['E01.171'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.35... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Study on reduction of acrylamide in fried bread sticks by addition of antioxidant of bamboo leaves and extract of green tea. | This paper investigated the efficiency of antioxidant of bamboo leaves (AOB) and extract of green tea (EGT) on the reduction of acrylamide in fried bread sticks and summarized the optimal levels of two additives. Seven experimental groups including a control group were organized for both of additives. Fried bread stick... | ['Acrylamide', 'Antioxidants', 'Bread', 'Chromatography, Liquid', 'Dose-Response Relationship, Drug', 'Food Additives', 'Food Contamination', 'Food Handling', 'Humans', 'Mass Spectrometry', 'Oxidation-Reduction', 'Plant Extracts', 'Plant Leaves', 'Sasa', 'Taste', 'Tea'] | 17,392,091 | [['D02.065.122.015', 'D02.241.081.069.094.015'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G07.203.300.100', 'J02.500.100'], ['E05.196.181.400'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.720.372.300', 'G07.203.300.514.500', 'J02.500.514.500'], ['J01.576.423.850.730.500.249', 'N06.850.460.400... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[Effect of intra-arterial and local administration of MCNU on cerebral malignant gliomas]. | Twenty-six patients with cerebral malignant glioma (7 cases of astrocytoma Grade 3, and 19 of astrocytoma Grade 4) were treated by intra-arterial and local administration of MCNU. Nineteen patients were treated in combination with local radiation in a dose of 60 Gy. Intra-arterial administration of MCNU was performed b... | ['Antineoplastic Agents', 'Brain Edema', 'Brain Neoplasms', 'Combined Modality Therapy', 'Drug Administration Schedule', 'Glioblastoma', 'Humans', 'Infusion Pumps, Implantable', 'Injections, Intra-Arterial', 'Injections, Intralesional', 'Liver', 'Nitrosourea Compounds'] | 7,755,390 | [['D27.505.954.248'], ['C10.228.140.187'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E02.186'], ['E02.319.283'], ['C04.557.465.625.600.380.080.335', 'C04.557.470.670.380.080.335', 'C04.557.580.625.600.380.080.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.505.254', 'E07.858.082.505... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transplantation of Endothelial Progenitor Cells Attenuates Lipopolysaccharide-Induced Lung Injury via Inhibiting the Inflammatory Secretion of Neutrophils in Rats. | BACKGROUND: Endothelial progenitor cells (EPCs) are special types of stem cells and are a potential novel therapeutic approach in acute lung injury (ALI). Transplantation of EPCs can ameliorate the inflammatory state by reducing adhesion and exudation of inflammatory cells. However, the mechanism underlying the effect ... | ['Acute Lung Injury', 'Animals', 'Endothelial Progenitor Cells', 'Inflammation', 'Lipopolysaccharides', 'Neutrophils', 'Rats', 'Rats, Sprague-Dawley'] | 30,611,320 | [['C08.381.520.500'], ['B01.050'], ['A11.148.174', 'A11.436.275.182'], ['C23.550.470'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145.229.637.415.583', 'A15.382.490.315.583', 'A15.382.680.689'], ['B01.050.1... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[2 cases of anaphylaxis from droperidol]. | Following two cases of anaphylactoid reactions during anaesthesia, immunoallergological investigations showed up the responsibility of droperidol, which probably acted by way of an anaphylactic mechanism. In both cases, there were no cardiovascular signs, the main clinical symptom being bronchospasm. The exceptional na... | ['Adult', 'Anaphylaxis', 'Anesthesia, General', 'Basophils', 'Bronchial Spasm', 'Droperidol', 'Drug Hypersensitivity', 'Female', 'Humans', 'Male'] | 6,517,399 | [['M01.060.116'], ['C20.543.480.099'], ['E03.155.197'], ['A11.118.637.415.120', 'A11.627.340.120', 'A15.145.229.637.415.120', 'A15.382.490.315.120'], ['C08.127.321'], ['D02.522.352.343', 'D03.633.100.103.393'], ['C20.543.206', 'C25.100.468'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Ovarian function during hormonal replacement therapy in perimenopausal women. | To determine the need for contraception during Hormonal Replacement Therapy (HRT) in perimenopausal women, ultrasound monitoring of ovarian function was performed on 10 perimenopausal women in the second month of treatment. All patients were not at risk of unwanted pregnancy during the study period and had last regular... | ['Administration, Oral', 'Drug Implants', 'Dydrogesterone', 'Estrogen Replacement Therapy', 'Estrogens', 'Female', 'Humans', 'Menopause', 'Middle Aged', 'Ovary', 'Ovulation', 'Time Factors', 'Ultrasonography'] | 8,342,457 | [['E02.319.267.100'], ['D26.255.210.315'], ['D04.210.500.745.432.296'], ['E02.319.452.150'], ['D27.505.696.399.472.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.157.500', 'G08.686.841.249.500'], ['M01.060.116.630'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['G08.686.784.690'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of dietborne copper and silver on reproduction by Ceriodaphnia dubia. | Recent studies have indicated the potential for dietborne metals as an important exposure pathway for metal toxicity in freshwater organisms. We conducted a study in which freshwater cladocerans (Ceriodaphnia dubia) were fed green algae (either Pseudokirchneriella subcapitata or Chlorella vulgaris) that were grown in A... | ['Animals', 'Copper', 'Crustacea', 'Diet', 'Eukaryota', 'Reproduction', 'Silver'] | 18,710,300 | [['B01.050'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['B01.050.500.131.365'], ['G07.203.650.240'], ['B01'], ['G08.686.784'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Synthesis cloning and expressions in E coli of human insulin A and B chain genes]. | Human insulin A and B chain genes were designed and synthesized by using a rapid and simple method. The synthesized A and B chain genes were cloned separately. The expression (plasmids) pWR 590-HIA and pWR 590-HIB were constructed, and the two plasmids can direct the synthesis of the approximately 590 amino acid-long t... | ['Amino Acid Sequence', 'Base Sequence', 'Cloning, Molecular', 'Escherichia coli', 'Genes, Synthetic', 'Humans', 'Insulin', 'Molecular Sequence Data', 'Plasmids', 'Recombination, Genetic'] | 1,476,017 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.340.024.340.465'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Changes in sex steroids, gonadotropins, prolactin, and inhibin in pregnant and nonpregnant Japanese black bears (Ursus thibetanus japonicus). | We examined changes in the concentrations of serum progesterone (P4), estradiol-17beta (E2), FSH, LH, prolactin (PRL), and inhibin to determine their interaction and their effect on the reproductive endocrine controls of pregnant and nonpregnant female Japanese black bears. Fourteen female bears were used in this study... | ['Animals', 'Estradiol', 'Female', 'Follicle Stimulating Hormone', 'Gonadal Steroid Hormones', 'Gonadotropins, Pituitary', 'Inhibins', 'Luteinizing Hormone', 'Pregnancy', 'Progesterone', 'Prolactin', 'Pseudopregnancy', 'Seasons', 'Ursidae'] | 11,566,720 | [['B01.050'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['D06.472.334.851'], ['D06.472.699.322.576', 'D06.472.699.631.525.343', 'D12.644.548.691.525.343'], ['D06.472.334.968', 'D06.472.699.337', 'D12.644.548.387', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Determination of three-dimensional low-resolution viral structure from solution x-ray scattering data. | The capsid is modeled as a region of constant electron density located between inner and outer envelopes that exhibit icosahedral symmetry. For computational purposes the envelopes are represented as truncated sums of weighted icosahedral harmonics. Methods are described for estimating the weights from x-ray solution s... | ['Biophysical Phenomena', 'Biophysics', 'Bromovirus', 'Capsid', 'Comovirus', 'Electrons', 'Mathematics', 'Models, Biological', 'Molecular Structure', 'Scattering, Radiation', 'Viruses', 'X-Rays'] | 8,527,677 | [['G01.154'], ['H01.158.344', 'H01.671.100'], ['B04.715.081.080', 'B04.715.464.080', 'B04.820.578.282.080'], ['A21.249.500.250'], ['B04.715.464.150', 'B04.715.700.150', 'B04.820.578.813.150'], ['G01.249.335', 'G01.358.500.750'], ['H01.548'], ['E05.599.395'], ['G02.111.570', 'G02.466'], ['E05.196.822', 'G01.867'], ['B04... | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytotoxicity of millimolar concentrations of ethanol on HepG2 human tumor cell line compared to normal rat hepatocytes in vitro. | PURPOSE: The antiproliferative effect of high concentrations of ethanol (80-100 mmol) on liver carcinoma is well known. However, the high concentrations of ethanol affect both tumor cells and normal hepatocytes. The present study was designed to determine the effect of low ethanol concentrations (0-10 mmol) on cell pro... | ['Alcohol Dehydrogenase', 'Animals', 'Apoptosis', 'Carcinoma, Hepatocellular', 'Cell Division', 'Cells, Cultured', 'DNA Fragmentation', 'Dose-Response Relationship, Drug', 'Enzyme Inhibitors', 'Ethanol', 'Fomepizole', 'Humans', 'L-Lactate Dehydrogenase', 'Liver', 'Liver Neoplasms', 'Male', 'Necrosis', 'Pyrazoles', 'Rat... | 11,003,562 | [['D08.811.682.047.820.250'], ['B01.050'], ['G04.146.954.035'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['G05.200.230'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.505.519.389'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Optical coherence tomography imaging in complicated acute myocardial infarction treated with primary angioplasty and AngioJet. | We describe the case of a 47-year-old man presenting with inferior acute myocardial infarction complicated by complete atrioventricular block and cardiogenic shock, who underwent primary angioplasty and rheolytic thrombectomy with AngioJet and subsequent evaluation by optical coherence tomography. Optical coherence tom... | ['Angioplasty, Balloon, Coronary', 'Atrioventricular Block', 'Coronary Angiography', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Predictive Value of Tests', 'Shock, Cardiogenic', 'Thrombectomy', 'Tomography, Optical Coherence', 'Treatment Outcome'] | 19,412,119 | [['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['C14.280.067.558.230', 'C14.280.123.500.230', 'C23.550.073.425.062'], ['E01.370.350.130.625', 'E01.370.350.700.060.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Electrophoretic mobilities of PEGylated gold NPs. | Electromigration of nanoparticles (NPs) is relevant to many technological and biological applications. We correlate the experimentally observed electromigration of Au NPs with a closed-form theoretical model that furnishes key NP characteristics, including the previously unknown values of Au NP core æ-potential, PEG-co... | ['Electrophoresis', 'Gold', 'Hydrogel, Polyethylene Glycol Dimethacrylate', 'Metal Nanoparticles', 'Models, Theoretical', 'Particle Size', 'Polyethylene Glycols'] | 20,958,038 | [['E05.196.401', 'E05.301.300'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['D02.033.455.250.700.485', 'D05.750.219.500', 'D05.750.741.485', 'D20.280.320.609.500', 'D25.720.532.500', 'D25.720.741.485', 'D26.255.165.320.375.375', 'J01.637.051.720.584.500', 'J01.637.051.720.741.485'], ['J01.637.512.600.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Improving the titer of recombinant adenovirus by suppressing problematic transgene transcription during packaging. | A new strategy to package "problematic" transgenes in adenovirus was developed that was based on modifications of the tetracycline-inducible system. This strategy used two components: the adenoviral genome containing the transgene under control of a hybrid TRE promoter/SV40 enhancer and a trans-encoded tTS suppressor U... | ['Adenoviridae', 'Animals', 'Base Sequence', 'Gene Expression Regulation, Viral', 'Genetic Vectors', 'HeLa Cells', 'Humans', 'Jurkat Cells', 'Luciferases', 'Molecular Sequence Data', 'Plasmids', 'Rats', 'Rats, Sprague-Dawley', 'Transcription, Genetic', 'Transduction, Genetic', 'Transgenes', 'Virus Assembly'] | 18,254,384 | [['B04.280.030'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G05.308.385'], ['G05.360.337'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.495', 'A11.251.860.180.495', 'A15.382.490.555.567.569.440'], ['D08... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells. | BACKGROUND: Folic acid [corrected] plays an essential role in cellular metabolism. Its deficiency can lead to neural tube defects. However, optimization of body folate homeostasis can reduce the incidence of neural tube defects and may decrease the risk of Alzheimer and cardiovascular diseases and cancer. Hence, food f... | ['Blotting, Western', 'Caco-2 Cells', 'Carrier Proteins', 'Dietary Supplements', 'Down-Regulation', 'Epithelial Cells', 'Folate Receptors, GPI-Anchored', 'Folic Acid', 'Humans', 'Intestinal Mucosa', 'Intestines', 'Kidney', 'Membrane Transport Proteins', 'Proton-Coupled Folate Transporter', 'RNA, Messenger', 'Receptors,... | 17,616,776 | [['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['D12.776.157'], ['G07.203.300.456', 'J02.500.456'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A11.436'], ['D12.776.157.530.450.074.500.299.500'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[A photographic microfluorimetric method for determining the DNA content in individual human chromosomes]. | A method for determination of DNA contents in individual human chromosomes has been elaborated based of the two step analysis: 1) identification of chromosomes by Q-banding; 2) photographic microfluorimetry of chromosomes after the Feulgen staining (a fluorescent variant using a Schiff-type reagent of Auramine-SO2). Th... | ['Animals', 'Cells, Cultured', 'Chromosome Banding', 'Chromosomes, Human', 'Coloring Agents', 'Cytophotometry', 'DNA', 'Humans', 'Lymphocytes', 'Metaphase', 'Photography', 'Rosaniline Dyes', 'Staining and Labeling'] | 2,483,280 | [['B01.050'], ['A11.251'], ['E01.370.225.500.385.130', 'E01.370.225.500.620.670.130', 'E01.370.225.750.600.670.130', 'E05.200.500.385.130', 'E05.200.500.620.670.130', 'E05.200.750.600.670.130', 'E05.242.385.130', 'E05.393.285.130'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['D27.720.233'], ['E01.370.225.500.386'... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Sildenafil use and relevant risk factors among middle-aged or elderly male clients of female commercial sex workers in the central areas of Guangxi, China]. | OBJECTIVE: To understand the illegal sidenafil use among middle-aged and elderly male clients of female sex workers (FSWs) in central region of Guangxi as well as on related risk factors. Initial evaluation regarding the effect of illegal sidenafil use on HIV infection among the middle-aged and elderly men was also con... | ['Age Distribution', 'Aged', 'China', 'Condoms', 'Female', 'HIV Infections', 'Humans', 'Male', 'Middle Aged', 'Piperazines', 'Prescription Drug Misuse', 'Prevalence', 'Purines', 'Risk Factors', 'Sex Work', 'Sex Workers', 'Sexual Partners', 'Sildenafil Citrate', 'Sulfonamides', 'Syphilis'] | 25,598,251 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['Z01.252.474.164'], ['E07.190.270.150'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D03.3... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Interpretation of French Society of ENT guidelines on the roles of the various treatment options in childhood obstructive sleep apnea-hypopnea syndrome]. | The French Society of ENT and Head Neck Surgery?SFORL?present the guidelines on the roles of the various treatment options in childhood obstructive sleep apnea in May 2018?this paper is the interpretation of the guidelines. | ['Child', 'France', 'Humans', 'Practice Guidelines as Topic', 'Sleep Apnea, Obstructive', 'Societies, Medical'] | 32,086,910 | [['M01.060.406'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.700.350.650', 'N05.700.350.650'], ['C08.618.085.852.850', 'C10.886.425.800.750.850'], ['N03.540.828.589']] | ['Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The protein-specific phosphatase 1 antagonizes the beta-adrenergic increase of the cardiac Ca current. | In isolated ventricular cells from the adult guinea pig heart the slow Ca current was recorded during beta-adrenergic stimulation and during cell dialysis with a protein-specific phosphatase-1 (PPase-1). The increase in the amplitude of ICa during bath application of isoprenaline (5 X 10(-8) M) could be completely reve... | ['Animals', 'Calcium', 'Guinea Pigs', 'Heart', 'In Vitro Techniques', 'Ion Channels', 'Isoproterenol', 'Myocardium', 'Phosphoproteins', 'Ribosomal Proteins'] | 2,430,258 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['B01.050.150.900.649.313.992.550'], ['A07.541'], ['E05.481'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559.389.657.166.175.649'], ['A02.633.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Salmonella typhimurium mutants defective in the formate dehydrogenase linked to nitrate reductase. | Six fdn mutants of Salmonella typhimurium defective in the formation of nitrate reductase-linked formate dehydrogenase (FDHN) but capable of producing both the hydrogenase-linked formate dehydrogenase (FDHH) and nitrate reductase were characterized. Results of phage P22 transduction experiments indicated that there may... | ['Aldehyde Oxidoreductases', 'Ascorbic Acid', 'Chromosome Mapping', 'Chromosomes, Bacterial', 'Cytochrome b Group', 'Cytochromes', 'Formate Dehydrogenases', 'Mutation', 'Nitrate Reductases', 'Photosystem II Protein Complex', 'Salmonella typhimurium'] | 7,035,433 | [['D08.811.682.657.163'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['E05.393.183'], ['A11.284.187.190', 'A20.812', 'G05.360.162.190'], ['D08.244.187', 'D12.776.422.220.187'], ['D08.244', 'D12.776.422.220'], ['D08.811.682.657.180'], ['G05.365.590'], ['D08.811.682.655.500'], ['D05.500.562.488.750', ... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lung cancer risk and vitamin A consumption in New Mexico. | The association between dietary intake of vitamin A and lung cancer risk was examined in a population-based, case-control study of 447 patients and 759 control subjects in New Mexico. A food frequency interview was used to measure usual consumption of total vitamin A retinol, preformed vitamin A, and carotene. With all... | ['Aged', 'Carcinoma', 'Carotenoids', 'Diet', 'European Continental Ancestry Group', 'Female', 'Hispanic Americans', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'New Mexico', 'Risk', 'Smoking', 'Vitamin A'] | 3,970,450 | [['M01.060.116.100'], ['C04.557.470.200'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['G07.203.650.240'], ['M01.686.508.400'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.11... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A model for computer simulation of P-glycoprotein and transmembrane delta pH-mediated anthracycline transport in multidrug-resistant tumor cells. | Anthracycline resistance in multidrug-resistant (MDR) tumor cells is due in part to a reduced cellular drug accumulation. Using a simple kinetic model and numerical computer simulations, we have analyzed mathematically the following possible mechanisms controlling fluxes of the membrane permeable anthracyclines in MDR ... | ['Animals', 'Antibiotics, Antineoplastic', 'Biological Transport', 'Carcinoma, Ehrlich Tumor', 'Cell Line', 'Cell Membrane', 'Computer Simulation', 'Daunorubicin', 'Drug Resistance', 'Hydrogen-Ion Concentration', 'Kinetics', 'Mathematics', 'Mice', 'Models, Biological', 'Neoplasm Proteins'] | 2,242,381 | [['B01.050'], ['D27.505.954.248.106'], ['G03.143'], ['C04.557.470.200.200', 'C04.619.169'], ['A11.251.210'], ['A11.284.149'], ['L01.224.160'], ['D02.455.426.559.847.562.050.200', 'D04.615.562.050.200', 'D09.408.051.059.200'], ['G07.690.773.984'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['H01.548'], ['B01.050.150.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[PROGNOSTIC SIGNIFICANCE OF ADJUVANT RADIOTHERAPY IN EARLY IB1 STAGE CERVICAL CANCER]. | The cervical cancer is one of the most common malignancies. Worldwide 500,000 women a year become ill from cervical cancer. The aim of the study was to establish the role of adjuvant radiotherapy in patients with IB1 cervical cancer in terms of disease free survival. Between 2002-2012, 132 patients diagnosed as IB1 sta... | ['Cervix Uteri', 'Disease-Free Survival', 'Female', 'Humans', 'Hysterectomy', 'Lymph Node Excision', 'Lymph Nodes', 'Neoplasm Staging', 'Prognosis', 'Radiotherapy, Adjuvant', 'Uterine Cervical Neoplasms'] | 26,817,258 | [['A05.360.319.679.256'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['E04.446'], ['A10.549.400', 'A15.382.520.604.412'], ['E01.789.625']... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Osteocalcin gene Hind III polymorphism is not correlated with calcium oxalate stone disease. | The formation of urinary stones is presumed to be associated with polymorphism of the osteocalcin gene. The most frequently seen polymorphism is the Hind III type located at the promoter region. This polymorphism has been used as a genetic marker in the search for a correlation between urolithiasis and normal subjects.... | ['Adult', 'Aged', 'Calcium Oxalate', 'Female', 'Humans', 'Male', 'Middle Aged', 'Osteocalcin', 'Polymorphism, Genetic', 'Site-Specific DNA-Methyltransferase (Adenine-Specific)', 'Urinary Calculi'] | 11,396,736 | [['M01.060.116'], ['M01.060.116.100'], ['D02.241.081.337.593.750.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D12.776.157.125.700'], ['G05.365.795'], ['D08.811.913.555.500.350.700'], ['C12.777.967.500', 'C13.351.968.967.500', 'C23.300.175.850']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Tubulitis in primary vascular and glomerular renal disease. | A semiquantitative light microscopic study of 274 renal biopsy and 12 nephrectomy specimens was carried out to assess the frequency and severity of tubulitis (mononuclear leukocytes in the renal tubular wall) in all common glomerular diseases, diabetic nephropathy, renal amyloidosis and renal artery stenosis. The exten... | ['Diabetic Nephropathies', 'Fibrosis', 'Glomerulonephritis', 'Humans', 'Kidney Tubules', 'Nephritis, Interstitial', 'Renal Artery Obstruction'] | 8,927,573 | [['C12.777.419.192', 'C13.351.968.419.192', 'C19.246.099.875'], ['C23.550.355'], ['C12.777.419.570.363', 'C13.351.968.419.570.363'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453.736.560'], ['C12.777.419.570.643', 'C13.351.968.419.570.643'], ['C12.777.419.775', 'C13.351.968.419.775', 'C14.907.137.727']... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of cilnidipine on lipids, lipoproteins and fibrinolytic system in hypertensive patients. | Sixteen Japanese patients of both sexes aged 46-78 years with essential hypertension were studied at the cardiac clinic of the Department of Cardiology, Shizuoka General Hospital, Shizuoka, Japan. Serum lipids, lipoproteins, plasma fibrinolytic parameters, renin and noradrenaline were determined before and after 3 mont... | ['Aged', 'Antihypertensive Agents', 'Blood Pressure', 'Calcium Channel Blockers', 'Dihydropyridines', 'Female', 'Humans', 'Hypertension', 'Lipids', 'Lipoproteins', 'Male', 'Middle Aged', 'Plasminogen Activator Inhibitor 1', 'Tissue Plasminogen Activator'] | 11,109,511 | [['M01.060.116.100'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['D03.383.725.203'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['D10'], ['D10.532', 'D12.776.521'], ['M01.060.116.630'], ['D12.644.861... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The HLA-DQ(alpha 1*0102, beta 1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA-DR(alpha 1*01, beta 1*1501) heterodimer. | The frequencies of DR2, DQ6-related DRB1, DQA1, DQB1 haplotypes were compared in 181 multiple sclerosis patients and 294 controls in Norway. All individuals carried either DR2 or DQ6, i.e., the DQ(alpha 1*0102, beta 1*0602) heterodimer. The DR(alpha 1*01, beta 1*1501) and the DQ(alpha 1*0102, beta 1*0602) heterodimers ... | ['Alleles', 'Dimerization', 'Disease Susceptibility', 'Genotype', 'HLA-DQ Antigens', 'HLA-DQ alpha-Chains', 'HLA-DQ beta-Chains', 'HLA-DR Antigens', 'HLA-DRB1 Chains', 'Haplotypes', 'Humans', 'Multiple Sclerosis', 'Protein Conformation'] | 9,243,750 | [['G05.360.340.024.340.030'], ['G02.206', 'G03.230'], ['C23.550.291.687', 'G07.100.250'], ['G05.380'], ['D12.776.395.550.509.400.430', 'D12.776.543.550.440.400.430', 'D23.050.301.500.400.400.430', 'D23.050.301.500.450.400.430', 'D23.050.705.552.410.400.430', 'D23.050.705.552.450.400.430'], ['D12.776.395.550.509.400.430... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor. | Castration-recurrent prostate cancer (CRPC) is suspected to depend on androgen receptor (AR). The AF-1 region in the amino-terminal domain (NTD) of AR contains most, if not all, of the transcriptional activity. Here we identify EPI-001, a small molecule that blocked transactivation of the NTD and was specific for inhib... | ['Androgen Receptor Antagonists', 'Androgens', 'Animals', 'Antineoplastic Agents, Hormonal', 'Apoptosis', 'Benzhydryl Compounds', 'CREB-Binding Protein', 'Castration', 'Cell Line, Tumor', 'Cell Proliferation', 'Chlorohydrins', 'DNA', 'Gene Expression', 'Humans', 'Ligands', 'Male', 'Mice', 'Mice, Inbred NOD', 'Mice, SCI... | 20,541,699 | [['D06.347.065.249', 'D27.505.696.399.450.065.249'], ['D27.505.696.399.472.161'], ['B01.050'], ['D27.505.954.248.169'], ['G04.146.954.035'], ['D02.455.426.559.389.115'], ['D08.811.913.050.134.415.500.575.249', 'D12.776.930.680.300'], ['E04.270.282', 'E04.950.165'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Decreased Beclin-1 expression is correlated with the growth of the primary tumor in patients with squamous cell carcinoma and adenocarcinoma of the lung. | Beclin-1 is a Bcl-2-interacting protein, and it may delay cell cycle progression and induce autophagy. The function and expression of Beclin-1 and Bcl-2 in squamous cell carcinoma and adenocarcinoma of the lung remain largely unknown. Herein, we investigated the expression of Beclin-1 and Bcl-2 in squamous cell carcino... | ['Adenocarcinoma', 'Adult', 'Aged', 'Aged, 80 and over', 'Apoptosis Regulatory Proteins', 'Beclin-1', 'Biomarkers, Tumor', 'Carcinoma, Squamous Cell', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Membrane Proteins', 'Middle Aged', 'Neoplasm Staging', 'Republic of Korea', 'Survival Rate', 'Tissue Array Analysis'] | 21,777,947 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.644.360.075', 'D12.776.476.075'], ['D12.644.360.075.335', 'D12.776.094.500', 'D12.776.476.075.335'], ['D23.101.140'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16. | A young girl with clinical features of pachyonychia congenita type 1 was unusual in that the typical skin and nail changes were not noted until the age of 6 years. Direct sequencing of the KRT16A gene, encoding keratin K16, revealed a novel mutation K354N in the central 2B domain of the K16 polypeptide. The mutation cr... | ['Child', 'Female', 'Humans', 'Keratins', 'Mutation, Missense', 'Nails, Malformed'] | 11,359,398 | [['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D05.750.078.593.450', 'D12.776.220.475.450', 'D12.776.860.607'], ['G05.365.590.650'], ['C23.300.820']] | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Recovery of a medieval Brucella melitensis genome using shotgun metagenomics. | Shotgun metagenomics provides a powerful assumption-free approach to the recovery of pathogen genomes from contemporary and historical material. We sequenced the metagenome of a calcified nodule from the skeleton of a 14th-century middle-aged male excavated from the medieval Sardinian settlement of Geridu. We obtained ... | ['Brucella melitensis', 'Genome, Bacterial', 'Metagenomics'] | 25,028,426 | [['B03.440.400.425.215.500.500', 'B03.660.050.070.100.500'], ['G05.360.340.358.207'], ['H01.158.273.343.350.261']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Medical technology at the end of life. What would physicians and nurses want for themselves? | BACKGROUND: Advance directives assume that patients are able to decide what interventions they would wish in the event of catastrophic illness. This study examines the preferences of nurses and physicians, who have extensive exposure to sick patients, for care at the end of life.METHODS: Nursing and medical staff of a ... | ['Adult', 'Advance Directives', 'Attitude of Health Personnel', 'Double Effect Principle', 'Ethics', 'Female', 'Hospitals, Community', 'Hospitals, Teaching', 'Humans', 'Intention', 'Male', 'Medical Staff, Hospital', 'Middle Aged', 'Multivariate Analysis', 'Nurses', 'Nursing Staff, Hospital', 'Physicians', 'Treatment Re... | 8,239,847 | [['M01.060.116'], ['I01.880.604.583.020', 'N03.706.535.020', 'N04.590.233.624.124.050'], ['F01.100.050', 'N05.300.100'], ['K01.752.566.479.101', 'N05.350.238'], ['K01.752.566.479', 'N05.350'], ['N02.278.421.306'], ['N02.278.020.300', 'N02.278.421.639'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658.650', '... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The Role of Surgical Resection for Stage IV Gastric Cancer With Synchronous Hepatic Metastasis. | BACKGROUND: With improved responses to chemotherapy and targeted treatments, the role of surgery in metastatic gastric cancer (MGC) to the liver needs to be revisited. We sought to examine whether surgical resection is associated with improvement of long-term survival.METHODS: The National Cancer Database was queried f... | ['Adenocarcinoma', 'Age Factors', 'Aged', 'Antineoplastic Agents', 'Chemotherapy, Adjuvant', 'Female', 'Follow-Up Studies', 'Gastrectomy', 'Humans', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Neoadjuvant Therapy', 'Neoplasm Grading', 'Neoplasm Staging', 'Palliative Care', 'Prognosis', 'Retrospective Studies', 'Stomach'... | 30,463,751 | [['C04.557.470.200.025'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D27.505.954.248'], ['E02.186.170', 'E02.319.170'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E04.210.419'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C0... | ['Diseases [C]', 'Health Care [N]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Halothane-induced relaxation of vascular smooth muscle: a possible contribution of increased cyclic GMP formation. | Halothane (0.75 to 2.25%) dose-dependently relaxed the vascular smooth muscle of endothelium-denuded rat aortae previously contracted with KCl, and the relaxing effect was not significantly affected by indomethacin nor dexamethasone, but partly inhibited by methylene blue. The cyclic GMP levels were increased by treatm... | ['Animals', 'Cyclic GMP', 'Dexamethasone', 'Halothane', 'In Vitro Techniques', 'Indomethacin', 'Male', 'Methylene Blue', 'Muscle, Smooth, Vascular', 'Rats', 'Rats, Inbred Strains', 'Vasodilator Agents'] | 1,645,814 | [['B01.050'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['D02.455.526.340'], ['E05.481'], ['D03.633.100.473.420'], ['D02.886.369.517', 'D03.633.300.783.517'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intracellular expression of camelid single-domain antibodies specific for influenza virus nucleoprotein uncovers distinct features of its nuclear localization. | UNLABELLED: Perturbation of protein-protein interactions relies mostly on genetic approaches or on chemical inhibition. Small RNA viruses, such as influenza A virus, do not easily lend themselves to the former approach, while chemical inhibition requires that the target protein be druggable. A lack of tools thus constr... | ['Animals', 'Cell Line', 'Cell Nucleus', 'Dogs', 'Gene Expression', 'Influenza A virus', 'Molecular Biology', 'Nucleocapsid Proteins', 'RNA-Binding Proteins', 'Single-Domain Antibodies', 'Viral Core Proteins', 'Virology', 'Virus Replication'] | 25,540,369 | [['B01.050'], ['A11.251.210'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['B01.050.150.900.649.313.750.250.216.200'], ['G05.297'], ['B04.820.480.968.405.400'], ['H01.158.201.636', 'H01.158.273.343.595', 'H01.181.122.650'], ['D12.776.964.970.600'], ['D12.776.157.725', 'D12.776.664.962'], ['D12.644.541.500.650.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
On the possible role of biliverdin stimulation of cyclic AMP levels as a trigger for liver regeneration in the rat. | Contrary to a recent report by Okazaki et al. (Biochem. biophys. Res. Commun., 1978, 81, 512-520) we show that high concentrations of biliverdin (100 mg/kg, i.p.) slightly reduce the mitotic rate in rat liver. Adenylate cyclase and both the "high Km" and "low Km" phosphodiesterase of rat liver plasma membranes are inhi... | ["3',5'-Cyclic-AMP Phosphodiesterases", 'Adenylyl Cyclases', 'Animals', 'Bilirubin', 'Biliverdine', 'Carrier Proteins', 'Cyclic AMP', 'Glutathione Transferase', 'Kinetics', 'Liver', 'Liver Regeneration', 'Male', 'Mitotic Index', 'Rats', 'Rats, Inbred Strains'] | 6,329,226 | [['D08.811.277.352.640.150', 'D12.644.360.008', 'D12.776.476.008'], ['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['D03.383.129.578.840.249.184.200', 'D03.633.400.909.249.184.200', 'D04.34... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High-Speed 3D Printing of High-Performance Thermosetting Polymers via Two-Stage Curing. | Design and direct fabrication of high-performance thermosets and composites via 3D printing are highly desirable in engineering applications. Most 3D printed thermosetting polymers to date suffer from poor mechanical properties and low printing speed. Here, a novel ink for high-speed 3D printing of high-performance epo... | ['Epoxy Compounds', 'Printing, Three-Dimensional', 'Silver'] | 29,383,797 | [['D02.355.291.411'], ['J01.897.564', 'L01.224.108.150.500', 'L01.296.110.150.500'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Ancestral Genomes: a resource for reconstructed ancestral genes and genomes across the tree of life. | A growing number of whole genome sequencing projects, in combination with development of phylogenetic methods for reconstructing gene evolution, have provided us with a window into genomes that existed millions, and even billions, of years ago. Ancestral Genomes (http://ancestralgenomes.org) is a resource for comprehen... | ['Animals', 'Databases, Genetic', 'Eukaryota', 'Evolution, Molecular', 'Extinction, Biological', 'Genes', 'Genes, Archaeal', 'Genes, Bacterial', 'Genes, Protozoan', 'Genome', 'Molecular Sequence Annotation', 'Phylogeny', 'Software'] | 30,371,900 | [['B01.050'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['B01'], ['G05.045.250', 'G16.075.250'], ['G16.510'], ['G05.360.340.024.340'], ['G05.360.340.024.340.364.124', 'G05.360.340.358.024.124', 'G05.360.340.358.050.500'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.... | ['Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A qualitative exploration of the experiences of community health animation on malaria control in rural Malawi. | BACKGROUND: While great strides have been achieved in fighting malaria through the Roll Back Malaria (RBM) strategy, the recent world malaria report shows an increase in malaria-related deaths compared to previous years. Malaria control tools are efficacious and effective in preventing the disease; however, the human b... | ['Disease Management', 'Female', 'Focus Groups', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Malaria', 'Malawi', 'Male', 'Middle Aged', 'Public Health', 'Qualitative Research', 'Rural Population'] | 32,197,660 | [['N04.590.607'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.752.530', 'C01.920.875'], ['Z01.058.290.175.500'], ['M01.060.116.630'], ['H02.403.720', 'N01.400.550', 'N06.850'], ['H01.770.644.241.850... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Named Groups [M]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
A comparative study of mechanical and homograft prostheses in the pulmonary position. | BACKGROUND: Homografts (HGs) are considered the gold standard for pulmonary valve replacement. However, to avoid further operations, the use of mechanical valves (MVs) might be considered, especially in patients who had had multiple prior operations or require an additional MV in another position.METHODS: Data of 19 pa... | ['Adolescent', 'Adult', 'Child', 'Female', 'Heart Valve Diseases', 'Heart Valve Prosthesis', 'Humans', 'Male', 'Prosthesis Design', 'Pulmonary Valve', 'Transplantation, Homologous', 'Young Adult'] | 19,853,107 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['C14.280.484'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.320.550', 'E07.695.680'], ['A07.541.510.738'], ['E04.936.864'], ['M01.060.116.815']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The role of adrenergic, purinergic and opiate receptors in the control of prostacyclin-induced contraction in the guinea-pig ileum. | The interactions between prostacyclin (PGI2) and adrenergic, opiate, purinergic receptor agonists and antagonists were studied in isolated segments of guinea-pig ileum by recording the changes in isometric tension. The contractile response of these preparations to PGI2 was rapid and qualitatively similar to the effect ... | ['Animals', 'Epoprostenol', 'Female', 'Guinea Pigs', 'Ileum', 'In Vitro Techniques', 'Male', 'Morphine', 'Muscle Contraction', 'Muscle, Smooth', 'Norepinephrine', 'Phentolamine', 'Phenylisopropyladenosine', 'Receptors, Adrenergic', 'Receptors, Neurotransmitter', 'Receptors, Opioid', 'Receptors, Purinergic', 'Theophylli... | 6,093,721 | [['B01.050'], ['D10.251.355.255.550.550.500', 'D23.469.050.175.725.550.500'], ['B01.050.150.900.649.313.992.550'], ['A03.556.124.684.249', 'A03.556.249.124'], ['E05.481'], ['D03.132.577.249.562.571', 'D03.605.497.607.587', 'D03.633.400.686.607.587', 'D04.615.723.795.576.571'], ['G11.427.494'], ['A02.633.570', 'A10.690.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain. | A novel LIM-homeodomain gene, Lhx9, was isolated by degenerate RT-PCR followed by mouse embryonic library screening. Lhx9 cDNA encodes a protein that is most closely related to Drosophila apterous and rodent Lhx2 proteins. The Lhx9 spatiotemporal pattern of expression during embryogenesis was similar but distinct from ... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Chick Embryo', 'Female', 'Gene Expression Regulation, Developmental', 'Homeodomain Proteins', 'Image Processing, Computer-Assisted', 'In Situ Hybridization', 'LIM-Homeodomain Proteins', 'Mice', 'Mice, Inbred C57BL', 'Molecular Sequence Data', 'Organ Specificity', 'Pr... | 9,880,598 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A13.350.150', 'A16.331.200'], ['G05.308.310'], ['D12.776.260.400'], ['L01.224.308'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325',... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Medical complications associated with carotid endarterectomy. North American Symptomatic Carotid Endarterectomy Trial (NASCET) | BACKGROUND AND PURPOSE: Carotid endarterectomy (CE) has been shown to be beneficial in patients with symptomatic high-grade (70% to 99%) internal carotid artery stenosis. To achieve this benefit, complications must be kept to a minimum. Complications not associated with the procedure itself, but related to medical cond... | ['Aged', 'Cardiovascular Diseases', 'Carotid Artery, Internal', 'Carotid Stenosis', 'Confusion', 'Endarterectomy', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Postoperative Complications', 'Proportional Hazards Models', 'Regression Analysis', 'Respiration Disorders', 'Risk Factors'] | 10,471,420 | [['M01.060.116.100'], ['C14'], ['A07.015.114.186.200.230'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['C10.597.606.337', 'C23.888.592.604.339', 'F01.700.250'], ['E04.100.814.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', ... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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