Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Topical gel formulation of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 confers protection against HIV-1 vaginal challenge in a humanized mouse model. | The new generation broadly neutralizing antibody VRC01 against HIV-1 shows great potential as a topically administered microbicide to prevent sexual transmission. We evaluated its efficacy in a RAG-hu humanized mouse model of vaginal HIV-1 transmission. Mice were challenged vaginally with R5 tropic HIV-1 BaL an hour af... | ['Administration, Topical', 'Animals', 'Antibodies, Monoclonal', 'Antibodies, Neutralizing', 'Chemistry, Pharmaceutical', 'DNA-Binding Proteins', 'Disease Models, Animal', 'Female', 'Gels', 'HIV Antibodies', 'HIV Infections', 'HIV-1', 'Homeodomain Proteins', 'Humans', 'Mice', 'Mice, Inbred BALB C', 'Vagina'] | 22,832,125 | [['E02.319.267.120'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['H01.158.703.007', 'H01.181.466'], ['D12.776.260'], ['C22.232', 'E05.598.500', 'E05.599.395.08... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The photochemical C2-C6 cyclization of enyne-allenes: interception of the fulvene diradical with a radical clock ring opening. | The mechanism of the photochemical C(2)-C(6) cyclization of enyne-allenes has been studied through radical clock, intramolecular kinetic isotope effect, and laser flash photolysis (LFP) experiments as well as density functional theory (DFT) and ab initio computations. While the photochemical cyclization of enyne-allene... | ['Alkadienes', 'Alkenes', 'Alkynes', 'Cyclization', 'Cyclopentanes', 'Kinetics', 'Lasers', 'Photolysis'] | 19,601,583 | [['D02.455.326.271.665.146'], ['D02.455.326.271'], ['D02.455.326.397'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['D02.455.426.392.368.450'], ['G01.374.661', 'G02.111.490'], ['E07.632.490', 'E07.710.520'], ['G02.740.685']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Conductance-voltage relations in large-conductance chloride channels in proliferating L6 myoblasts. | Large-conductance chloride channels (maxi-Cl channels) were studied in cultured myoblasts (L6 rat muscle cell line); in excised (inside-out) and in cell attached membrane patches using a conventional patch clamp method. The incidence of maxi-Cl channels was substantially higher in proliferating myoballs, then in quiesc... | ['Animals', 'Cell Line', 'Chloride Channels', 'Electric Conductivity', 'Electrophysiology', 'Ion Channel Gating', 'Kinetics', 'Membrane Potentials', 'Muscles', 'Patch-Clamp Techniques', 'Probability', 'Rats', 'Sodium Chloride'] | 7,835,680 | [['B01.050'], ['A11.251.210'], ['D12.776.157.530.400.175', 'D12.776.543.550.450.175', 'D12.776.543.585.400.175'], ['G01.358.500.249.277'], ['H01.158.344.528', 'H01.158.782.236'], ['G02.111.820.400', 'G04.835.400', 'G07.265.625'], ['G01.374.661', 'G02.111.490'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
The Race Idea in Reproductive Technologies: Beyond Epistemic Scientism and Technological Mastery. | This paper explores the limitations of epistemic scientism for understanding the role the concept of race plays in assisted reproductive technology (ART) practices. Two major limitations centre around the desire to use scientific knowledge to bring about social improvement. In the first case, undue focus is placed on d... | ['African Americans', 'Child', 'Continental Population Groups', 'European Continental Ancestry Group', 'Female', 'Humans', 'Internationality', 'Male', 'Parents', 'Politics', 'Reproductive Techniques, Assisted', 'Social Class', 'Socioeconomic Factors', 'Sperm Banks', 'Surrogate Mothers', 'United Kingdom', 'United States... | 26,615,542 | [['M01.686.508.100.100', 'M01.686.754.100'], ['M01.060.406'], ['M01.686.508'], ['M01.686.508.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620'], ['I01.738'], ['E02.875.800', 'E05.820.800'], ['I01.880.853.996.755', 'N01.824.782'], ['I01.880.... | ['Named Groups [M]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The influence of espresso coffee on neurocognitive function in HIV-infected patients. | The aim of our study was to evaluate the impact of coffee intake on cognitive function in persons living with HIV (PLWH). 130 PLWH with CD4 > 200 cells/mm(3), undetectable viral load, treated with HAART were included. A structured interview was applied and relevant clinical and laboratory data were assessed, including ... | ['Adult', 'Antiretroviral Therapy, Highly Active', 'Attention', 'Caffeine', 'Coffee', 'Cognition', 'Cognition Disorders', 'Executive Function', 'Female', 'HIV Infections', 'Humans', 'Male', 'Memory, Short-Term', 'Middle Aged', 'Neuropsychological Tests', 'Plant Extracts', 'Psychometrics', 'Regression Analysis', 'Viral ... | 26,932,511 | [['M01.060.116'], ['E02.319.310.075'], ['F02.830.104.214'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D20.215.784.249', 'G07.203.100.325', 'J02.200.325'], ['F02.463.188'], ['F03.615.250'], ['F02.463.217'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Symptoms, signs and early course of optic neuritis. | The study was an anlysis of the early course of optic neuritis based on the case histories of 185 patients, 57% of whom were females and 43% males. More than half of the patients suffered from multiple sclerosis. In 28% of the patients the etiology remained unknown. The most common initial symptom was acute decrease in... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Female', 'Humans', 'Male', 'Middle Aged', 'Optic Neuritis', 'Visual Acuity', 'Visual Fields'] | 1,174,002 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.292.700.550', 'C11.640.576'], ['E01.370.380.850.950', 'F02.463.593.932.901', 'G14.940'], ['F02.463.593.932.934', 'G14.950']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Wives and ex-wives: a new test for homogamy bias in the widowhood effect. | Increased mortality following the death of a spouse (the "widowhood effect") may be due to (1) causation, (2) bias from spousal similarity (homogamy), or (3) bias from shared environmental exposures. This article proposes new tests for bias in the widowhood effect by examining husbands, wives, and ex-wives in a longitu... | ['Adaptation, Psychological', 'Aged', 'Bias', 'Causality', 'Family Characteristics', 'Female', 'Humans', 'Models, Statistical', 'Mortality', 'Probability', 'Proportional Hazards Models', 'Regression Analysis', 'Risk Factors', 'Sex Factors', 'United States', 'Widowhood'] | 19,110,901 | [['F01.058'], ['M01.060.116.100'], ['N05.715.350.150', 'N06.850.490.500'], ['N05.715.350.200', 'N06.850.490.625'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.224.361', 'N01.824.308', 'N06.850.505.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Liability claims based on drug use. | The incidence of drug-related liability claims is discussed, and data from a number of studies in this area are reviewed. Drug categories that appear to cause the greatest problems are hormones, anticoagulants, adrenal steroids, and antibiotics. Focusing attention on these categories may enable the pharmacist to functi... | ['Drug-Related Side Effects and Adverse Reactions', 'Humans', 'Insurance, Liability', 'Malpractice'] | 6,617,491 | [['C25.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.443'], ['I01.880.604.583.524', 'N03.706.535.606']] | ['Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Species identification by experts and non-experts: comparing images from field guides. | Accurate species identification is fundamental when recording ecological data. However, the ability to correctly identify organisms visually is rarely questioned. We investigated how experts and non-experts compared in the identification of bumblebees, a group of insects of considerable conservation concern. Experts an... | ['Animals', 'Bees', 'Professional Competence', 'Reproducibility of Results'] | 27,644,140 | [['B01.050'], ['B01.050.500.131.617.720.500.500.875.387'], ['I02.399.630'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Ripple phase in asymmetric unilamellar bilayers with saturated and unsaturated phospholipids. | In a solution of phosphate-buffered saline (PBS), unilamellar bilayers with saturated phosphatidylcholines in one leaflet and negatively charged, unsaturated phospholipids in the other leaflet were observed in the ripple phase at room temperature using atomic force microscopy (AFM). This is the first observation of the... | ['Ions', 'Lipid Bilayers', 'Microscopy, Atomic Force', 'Phospholipids'] | 7,547,997 | [['D01.248.497'], ['D10.570.510', 'J01.637.087.500.510'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['D10.570.755']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Association of Mild to Moderate Aortic Valve Stenosis Progression With Higher Lipoprotein(a) and Oxidized Phospholipid Levels: Secondary Analysis of a Randomized Clinical Trial. | Importance: Several studies have reported an association of levels of lipoprotein(a) (Lp[a]) and the content of oxidized phospholipids on apolipoprotein B (OxPL-apoB) and apolipoprotein(a) (OxPL-apo[a]) with faster calcific aortic valve stenosis (CAVS) progression. However, whether this association is threshold or line... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anticholesteremic Agents', 'Aortic Valve', 'Aortic Valve Stenosis', 'Biomarkers', 'Disease Progression', 'Echocardiography, Doppler', 'Female', 'Humans', 'Lipoprotein(a)', 'Male', 'Middle Aged', 'Oxidation-Reduction', 'Phospholipids', 'Risk Factors', 'Rosuvastatin C... | 30,476,957 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.519.186.071.202', 'D27.505.954.557.500.202'], ['A07.541.510.110'], ['C14.280.484.048.750', 'C14.280.955.249'], ['D23.101'], ['C23.550.291.656'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pharmacokinetic study on piroxicam at the steady-state in elderly subjects and younger adults after administration of piroxicam beta-cyclodextrin. | The age effect on the kinetics of piroxicam at the steady-state after oral administration of piroxicam beta-cyclodextrin was evaluated. The mean plasma concentration of piroxicam at the steady-state was significantly higher in elderly subjects (9.30 +/- 0.69 micrograms/ml mean +/- s.e.) than in younger adults (6.24 +/-... | ['Adult', 'Aged', 'Aged, 80 and over', 'Aging', 'Cyclodextrins', 'Female', 'Humans', 'Male', 'Middle Aged', 'Piroxicam', 'beta-Cyclodextrins'] | 3,403,105 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['D04.345.103', 'D09.301.915.400.375', 'D09.698.365.855.400.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D02.886.665.500', 'D03.383.855.500'], ['D04.345.103.333', 'D09.301.915.400.375.333', 'D09.698.365.85... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Evidence for evolutionary stasis and genetic drift by genetic analysis of two equine influenza H3 viruses isolated in France. | The amino acid sequences of the HA(1) portion of the haemagglutinin of two equine A(H3N8) influenza viruses isolated in France in 1993 and 1998 were analysed to determine their evolutionary relationship with 51 other HA(1) amino acid sequences available in databanks. Our data show that the French strain isolated in 199... | ['Amino Acid Sequence', 'Animals', 'Evolution, Molecular', 'France', 'Gene Frequency', 'Hemagglutination Tests', 'Hemagglutinin Glycoproteins, Influenza Virus', 'Horse Diseases', 'Horses', 'Influenza A virus', 'Molecular Sequence Data', 'Orthomyxoviridae Infections', 'Phylogeny', 'RNA, Viral'] | 10,799,778 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G05.045.250', 'G16.075.250'], ['Z01.542.286'], ['G05.330'], ['E01.370.225.812.735.050.375', 'E05.200.812.735.050.375', 'E05.478.594.760.050.375'], ['D12.776.964.970.880.345.500'], ['C22.488'], ['B01.050.150.900.649.313.984.235.472'], ['B04.820.480.968.405.400'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Synthetic aperture-based beam compression for intravascular ultrasound imaging. | In this paper, intravascular ultrasound (IVUS) images acquired with a 64-element array transducer using a multistatic acquisition scheme are presented. The images are reconstructed from a collection of pulse-echo measurements using a synthetic aperture array imaging technique. The main limitations of IVUS imaging are a... | ['Computer Simulation', 'Coronary Vessels', 'Fourier Analysis', 'Humans', 'Models, Cardiovascular', 'Phantoms, Imaging', 'Signal Processing, Computer-Assisted', 'Transducers', 'Ultrasonography'] | 11,367,787 | [['L01.224.160'], ['A07.015.114.269', 'A07.015.908.194'], ['E05.377', 'G17.226', 'L01.224.800.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.161'], ['E07.671'], ['L01.224.800'], ['E07.305.812'], ['E01.370.350.850']] | ['Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Impaired IL-10 transcription and release in animal models of Gaucher disease macrophages. | A number of studies have shown altered cytokine levels in serum from Gaucher disease patients, including changes in levels of the anti-inflammatory cytokine, interleukin-10 (IL-10). However, the source of IL-10, or the mechanisms leading to changes in IL-10 serum levels are not known. We now show that mouse macrophages... | ['Animals', 'Cells, Cultured', 'Gaucher Disease', 'Glucosylceramidase', 'Inositol', 'Interleukin-10', 'Macrophages', 'Mice', 'Mice, Inbred C57BL', 'RNA, Messenger', 'Transcription, Genetic', 'Tumor Necrosis Factor-alpha'] | 19,380,242 | [['B01.050'], ['A11.251'], ['C10.228.140.163.100.435.825.400', 'C16.320.565.189.435.825.400', 'C16.320.565.398.641.803.441', 'C16.320.565.595.554.825.400', 'C18.452.132.100.435.825.400', 'C18.452.584.687.803.441', 'C18.452.648.189.435.825.400', 'C18.452.648.398.641.803.441', 'C18.452.648.595.554.825.400'], ['D08.811.27... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Recording of electroencephalograms and electrocardiograms during daytime sleep in trained canines: preparation of the sleeping dogs. | Although respiration in trained canines is well investigated, the process of preparing dogs has not been described in any great detail. Moreover, their daytime patterns of sleep and wakefulness during 1 or 2 h of electroencephalogram (EEG) and electrocardiogram (ECG) recordings are not clear. Therefore, we describe the... | ['Animals', 'Cerebral Cortex', 'Circadian Rhythm', 'Dogs', 'Electrocardiography', 'Electrodes', 'Electroencephalography', 'Female', 'Male', 'Polysomnography', 'Reaction Time', 'Reference Values', 'Sleep Stages', 'Sleep, REM', 'Wakefulness'] | 9,316,171 | [['B01.050'], ['A08.186.211.200.885.287.500'], ['G07.180.562.190'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E07.305.250'], ['E01.370.376.300', 'E01.370.405.245'], ['E01.370.520.625'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['E05.978.810'], ['F02.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Central pancreatectomy: a technique for the resection of pancreatic neck lesions. | HYPOTHESIS: Central pancreatectomy has been used sparingly because the spectrum of indications is quite narrow. Although historically used for traumatic pancreatic transection and chronic pancreatitis, it currently is reserved for selective management of pancreatic neck lesions that are benign or have low malignant pot... | ['Adenoma, Islet Cell', 'Cystadenoma, Serous', 'Female', 'Humans', 'Liposarcoma', 'Male', 'Mesenteric Veins', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Pancreatectomy', 'Pancreatic Neoplasms', 'Reoperation', 'Retrospective Studies', 'Tomography, X-Ray Computed'] | 16,549,696 | [['C04.557.470.035.100', 'C04.588.274.761.249', 'C04.588.322.475.249', 'C06.301.761.249', 'C06.689.667.249', 'C19.344.421.249'], ['C04.557.470.035.320.240', 'C04.557.470.590.485.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.550.420', 'C04.557.450.795.465'], ['A07.015.908.670.385'], ['M01.060.116... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Divergent toxicity of parathion in two freshwater invertebrates, orconectes rusticus and viviparus malleatus. | The toxicity of parathion and its metabolite paraoxon was examined in the crayfish Orconectes rusticus and the snail Viviparus malleatus and attempts were made to relate this to parathion uptake and metabolism. The crayfish was found to be very susceptible with all animals tested dying at 0.1 ppb of parathion in 48 hou... | ['Animals', 'Astacoidea', 'Dose-Response Relationship, Drug', 'Paraoxon', 'Parathion', 'Snails'] | 512,294 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Breast cancer diagnosis with a microwave thermoacoustic imaging technique-a numerical approach. | Microwave-induced thermoacoustic imaging (MITAI) is an imaging technique with great potential for detecting breast cancer at early stages. Thermoacoustic imaging (TAI) combines the advantages of both microwave and ultrasound imaging techniques. In the current study, a three-dimensional novel numerical simulation of TAI... | ['Acoustics', 'Breast Neoplasms', 'Electromagnetic Phenomena', 'Female', 'Humans', 'Mammary Glands, Human', 'Microwaves', 'Models, Biological', 'Temperature', 'Thermography'] | 30,919,269 | [['H01.671.031'], ['C04.588.180', 'C17.800.090.500'], ['G01.358.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.236.249', 'A10.336.532'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['E05.599.395'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.1... | ['Disciplines and Occupations [H]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Fathers' Stress in a Neonatal Intensive Care Unit. | BACKGROUND: Healthcare professionals in neonatal intensive care units (NICUs) tend to focus attention on the mothers and the newborn infants. Thus, fathers may find it difficult to establish an optimal father-child relationship and their stress may increase and persist during hospitalization.PURPOSE: To investigate the... | ['Denmark', 'Father-Child Relations', 'Fathers', 'Humans', 'Infant, Newborn', 'Intensive Care Units, Neonatal', 'Male', 'Program Evaluation', 'Stress, Psychological', 'Surveys and Questionnaires'] | 29,746,269 | [['Z01.542.816.124'], ['F01.829.263.370.290.110'], ['F01.829.263.500.320.100', 'I01.880.853.150.500.340.210', 'M01.620.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N02.278.388.493.390.380'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['F01.145.126.990', 'F02.830.900'], ['E05.31... | ['Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Hepatic exposure of metformin in patients with non-alcoholic fatty liver disease. | AIMS: Metformin is first-line treatment of type 2 diabetes mellitus and reduces cardiovascular events in patients with insulin resistance and type 2 diabetes. Target tissue for metformin action is thought to be the liver, where metformin distribution depends on facilitated transport by polyspecific transmembrane organi... | ['Adult', 'Aged', 'Biopsy', 'Carbon Radioisotopes', 'Diabetes Mellitus, Type 2', 'Female', 'Gene Expression Profiling', 'Humans', 'Hypoglycemic Agents', 'Liver', 'Male', 'Metformin', 'Middle Aged', 'Non-alcoholic Fatty Liver Disease', 'Organic Cation Transport Proteins', 'Positron Emission Tomography Computed Tomograph... | 30,973,968 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['C18.452.394.750.149', 'C19.246.300'], ['E05.393.332'], ['B01.050.150.900.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A novel population of cells in the peripheral blood of a cow with a neurofibrosarcoma. | An unusual population of leukocytes was observed in the peripheral blood of a cow with a large tumor burden, using flow microfluorimetry. This new population accounted for 50% of the total cells in the peripheral blood of this animal. These cells expressed the p150,95 molecule (bovine CD11c equivalent), identified by t... | ['Animals', 'Cattle', 'Cattle Diseases', 'Cytotoxicity, Immunologic', 'Female', 'Integrin alphaXbeta2', 'Leukocytes', 'Mesentery', 'Neurofibroma', 'Peritoneal Neoplasms'] | 2,251,765 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['G12.287'], ['D12.776.395.550.200.275', 'D12.776.543.550.200.275', 'D12.776.543.750.705.408.600.100', 'D12.776.543.750.705.833.249', 'D23.050.301.350.275'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['A01.923.047.025.600.451'], ['C04.557.580.... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Treatment of depression, anxiety, and trauma-related disorders during the perinatal period: A systematic review. | Women with psychiatric disorders during pregnancy and the postpartum period (i.e., perinatal period) are at increased risk for adverse maternal and child outcomes. Effective treatment of psychiatric disorders during the perinatal period is imperative. This review summarizes the outcomes of 78 studies focused on the tre... | ['Anxiety Disorders', 'Complementary Therapies', 'Depressive Disorder', 'Female', 'Humans', 'Pregnancy', 'Pregnancy Complications', 'Psychotherapy', 'Trauma and Stressor Related Disorders'] | 29,935,979 | [['F03.080'], ['E02.190'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['C13.703'], ['F04.754'], ['F03.950']] | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chemistry of cephalosporin antibiotics. 28. Preparation and biological activity of 3-(substituted)vinyl cephalosporins. | 3-(Substituted)vinylcephem nuclei have been prepared by the reaction of 3-formylcephem derivatives with stabilized phosphoranes. Appropriate synthetic steps allowed preparation of a series of 3-ethoxycarbonylvinyl- and 3-carboxyvinylcephem derivatives bearing a variety of 7-acylamino functions. The phenoxyacetyl and th... | ['Bacillus subtilis', 'Cephalosporins', 'Enterobacter', 'Escherichia coli', 'Klebsiella pneumoniae', 'Microbial Sensitivity Tests', 'Pseudomonas aeruginosa', 'Salmonella', 'Sarcina', 'Serratia marcescens', 'Shigella', 'Spectrophotometry, Ultraviolet', 'Staphylococcus aureus', 'Structure-Activity Relationship', 'Vinyl C... | 808,607 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['B03.440.450.425.275', 'B03.660.250.150.170'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Renal and cardiorespiratory effects of treatment with lactated Ringer's solution or physiologic saline (0.9% NaCl) solution in cats with experimentally induced urethral obstruction. | OBJECTIVE: To compare the renal and cardiorespiratory effects of IV treatment with lactated Ringer's solution (LRS) or physiologic saline (0.9% NaCl) solution (PSS) in severely decompensated cats with urethral obstruction (UO).ANIMALS: 14 cats (4 cats were used only to establish infusion rates).PROCEDURES: An occluded ... | ['Animals', 'Body Temperature', 'Cat Diseases', 'Cats', 'Diuresis', 'Fluid Therapy', 'Heart Rate', 'Isotonic Solutions', 'Kidney', 'Male', 'Orchiectomy', "Ringer's Lactate", 'Serum Albumin', 'Sodium Chloride', 'Urethral Obstruction'] | 20,594,088 | [['B01.050'], ['E01.370.600.875.374', 'G07.110'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['G08.852.179'], ['E02.319.360'], ['E01.370.600.875.500', 'G09.330.380.500'], ['D26.776.498'], ['A05.810.453'], ['E04.270.282.679', 'E04.950.165.679', 'E04.950.774.860.618'], ['D26.776.498.500.500'], ['D12.77... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tooth preparation. | This final article in the series describes the modification of teeth to improve their shape for the support and retention of RPDs. | ['Denture, Partial, Removable', 'Humans', 'Tooth Preparation, Prosthodontic'] | 11,325,154 | [['E06.780.346.760.943.413', 'E07.695.190.200.220.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E06.931.750']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of human unfertilized oocytes and pronuclear zygotes--correlation between chromosome/chromatin status and patient-related factors. | OBJECTIVE: The objective was to evaluate the relationship between ploidy and chromatin status of human unfertilized oocytes/zygotes and infertility history, female age, and stimulation regimens.STUDY DESIGN: Two hundred and eighty-nine unfertilized oocytes and 63 zygotes were subjected to cytogenetic analysis: karyotyp... | ['Adult', 'Age Factors', 'Aneuploidy', 'Cell Culture Techniques', 'Chromatin', 'Chromosome Aberrations', 'Female', 'Fertilization in Vitro', 'Humans', 'Infertility', 'Oocytes', 'Ovulation Induction', 'Spectral Karyotyping', 'Zygote'] | 16,650,520 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C23.550.210.050', 'G05.365.590.175.050', 'G05.700.131'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['C23.550.210', 'G05.365.590.175'], ['E02.875.... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Morphological, microstereological and immunohistoenzymological studies of the jejuni of infants with recurrent constructive bronchitis and chronic diarrhea due to cow's milk protein allergy]. | Morphological, microstereological and immunohistoenzymatic technique were used to assess jejunal biopsy samples obtained from 17 infants suffering from chronic diarrhoea and bronchitis spastica (the study group), and 5 infants with chronic diarrhoea and weight deficiency (group G). In the first group, histopathological... | ['Animals', 'Bronchitis', 'Chronic Disease', 'Connective Tissue', 'Diarrhea', 'Humans', 'Immunoglobulin E', 'Immunoglobulin G', 'Immunoglobulin M', 'Infant, Newborn', 'Jejunum', 'Lymphocytes', 'Milk', 'Milk Hypersensitivity', 'Milk Proteins'] | 8,710,421 | [['B01.050'], ['C01.748.099', 'C08.127.446', 'C08.381.495.146', 'C08.730.099'], ['C23.550.291.500'], ['A10.165'], ['C23.888.821.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D12.776.377.715.548.114.619.312'], ['D12.776.124.486.485.114.619... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
The penultimate arginine of the carboxyl terminus determines slow desensitization in a P2X receptor from the cattle tick Boophilus microplus. | P2X ion channels have been functionally characterized from a range of eukaryotes. Although these receptors can be broadly classified into fast and slow desensitizing, the molecular mechanisms underlying current desensitization are not fully understood. Here, we describe the characterization of a P2X receptor from the c... | ['Amino Acid Sequence', 'Animals', 'Arginine', 'Cattle', 'Female', 'Molecular Sequence Data', 'Mutation', 'Peptide Fragments', 'Protein Structure, Tertiary', 'Receptors, Purinergic P2X', 'Ticks', 'Time Factors', 'Xenopus laevis'] | 21,212,138 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['B01.050.150.900.649.313.500.380.271'], ['L01.453.245.667'], ['G05.365.590'], ['D12.644.541'], ['G02.111.570.820.709.610'], ['D12.776.157.530.400.400.750', 'D12.776.543.550.450.500.600', 'D12.776.543.58... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Activation of arachidonic acid metabolism in mouse macrophages by bacterial amphiphiles. | The relative activities of lipoteichoic acid (LTA) from four Gram-positive bacteria were compared to different lipopolysaccharide (LPS) preparations for activation of arachidonic acid metabolism in mouse peritoneal macrophages. Total eicosanoid was determined in cultures labeled with [3H]-arachidonic acid. Prostaglandi... | ['Animals', 'Arachidonic Acid', 'Cells, Cultured', 'Chromatography', 'Eicosanoids', 'Gram-Positive Bacteria', 'Lipopolysaccharides', 'Macrophage Activation', 'Macrophages, Peritoneal', 'Mice', 'Mice, Inbred ICR', 'Salmonella', 'Sepharose', 'Streptomyces', 'Teichoic Acids', 'Tetradecanoylphorbol Acetate'] | 7,996,048 | [['B01.050'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['A11.251'], ['E05.196.181'], ['D10.251.355.255', 'D23.469.050.175'], ['B03.510'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['G12.287.500'], ['A11.329.372.630', 'A11.627.482.630', 'A11.733.397.630',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Morphologic variations and aging in the atrioventricular conduction system of large breed dogs. | The microscopic anatomy of the atrioventricular node, bundle of His, both bundle branches and surrounding fibrous cardiac skeleton was studied in 40 large breed dogs of various ages. In the AV conduction system of all dogs over five years of age there was an increase of fibrous connective tissue, an infiltration of adi... | ['Aging', 'Animals', 'Atrioventricular Node', 'Dogs', 'Heart', 'Heart Conduction System'] | 426,312 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PapX, a P fimbrial operon-encoded inhibitor of motility in uropathogenic Escherichia coli. | Motility and adherence are two integral aspects of bacterial pathogenesis. Adherence, often mediated by fimbriae, permits bacteria to attach to host cells and establish infection, whereas flagellum-driven motility allows bacteria to disseminate to sites more advantageous for colonization. Both fimbriae and flagella hav... | ['Animals', 'Bacterial Adhesion', 'Electrophoretic Mobility Shift Assay', 'Escherichia coli', 'Escherichia coli Proteins', 'Fimbriae Proteins', 'Fimbriae, Bacterial', 'Flagella', 'Flagellin', 'Fluorescent Antibody Technique, Indirect', 'Gene Expression', 'Gene Expression Regulation, Bacterial', 'Mice', 'Oligonucleotide... | 18,710,869 | [['B01.050'], ['G06.099.050'], ['E05.196.401.500'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['D12.776.097.120.425', 'D12.776.543.100.300'], ['A11.284.180.285', 'A20.843'], ['A11.284.180.290'], ['D12.776.097.380'], ['E01.370.225.500.607.512.240.310', 'E01.370.225.750.551.512.240.310'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[AIDS, activism, and the regulation of clinical trials in Brazil: Protocol 028]. | This paper examines the politics and practices of drug evaluation in Brazil. It traces the history of AIDS activists' influence on the organization of modern clinical trials and their scientific rationale. Using the Merck indinavir trial as a case study, the authors discuss how organized civil society has developed str... | ['Acquired Immunodeficiency Syndrome', 'Brazil', 'Clinical Protocols', 'Clinical Trials as Topic', 'Community Participation', 'Conflict of Interest', 'Drug Approval', 'Ethics, Professional', 'HIV Protease Inhibitors', 'Humans', 'Indinavir', 'Legislation, Drug'] | 11,514,867 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['Z01.107.757.176'], ['E02.183', 'N05.715.360.330.125'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['N02.421.143.21... | ['Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Humanities [K]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
In vitro folding and thermodynamic stability of an antibody fragment selected in vivo for high expression levels in Escherichia coli cytoplasm. | We recently isolated a mutant of a human anti-beta-galactosidase single chain antibody fragment (scFv) able to fold at high levels in Escherichia coli cytoplasm. When targeted to the periplasm, this mutant and the wild-type scFv are both expressed at comparable levels in a soluble, active and oxidized form. If a reduci... | ['Cytoplasm', 'Disulfides', 'Escherichia coli', 'Humans', 'Immunoglobulin Fragments', 'Kinetics', 'Mutation', 'Oxidation-Reduction', 'Periplasm', 'Protein Binding', 'Protein Denaturation', 'Protein Folding', 'Protein Renaturation', 'Recombinant Proteins', 'Solubility', 'Thermodynamics', 'Urea'] | 10,525,415 | [['A11.284.430.214'], ['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.541.500', 'D12.776.124.486.485.680', 'D12.776.124.790.651.680', 'D12.776.377.715.548.680'], ['G01.374.661', 'G02... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Challenge of pigs with classical swine fever viruses after C-strain vaccination reveals remarkably rapid protection and insights into early immunity. | Pre-emptive culling is becoming increasingly questioned as a means of controlling animal diseases, including classical swine fever (CSF). This has prompted discussions on the use of emergency vaccination to control future CSF outbreaks in domestic pigs. Despite a long history of safe use in endemic areas, there is a pa... | ['Animals', 'Antibodies, Neutralizing', 'Classical Swine Fever', 'Classical Swine Fever Virus', 'Interferon-gamma', 'Male', 'Swine', 'T-Lymphocytes', 'Time Factors', 'Vaccination'] | 22,235,283 | [['B01.050'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['C01.925.782.350.675.200', 'C22.905.170'], ['B04.820.578.344.700.125'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Protein-hydrocarbon interactions. Interactions of various proteins with decane in the presence of alcohols. | 1. Solutions of proteins were subjected to gentle agitation in the presence of small quantities of decane containing different alcohols. 2. Some of the protein was lost from solution and adsorbed on the surface of the emulsion formed; at the same time some decane was bound to the protein remaining in solution. 3. Compa... | ['Adsorption', 'Alcohols', 'Alkanes', 'Animals', 'Buffers', 'Carbon Isotopes', 'Cattle', 'Emulsions', 'Hydrogen-Ion Concentration', 'Muramidase', 'Protein Binding', 'Proteins', 'Ribonucleases', 'Serum Albumin, Bovine', 'Surface Properties', 'Vibration'] | 5,463,329 | [['G01.030', 'G02.020'], ['D02.033'], ['D02.455.326.146'], ['B01.050'], ['D27.720.470.280'], ['D01.268.150.075', 'D01.496.123'], ['B01.050.150.900.649.313.500.380.271'], ['D20.280.260', 'D26.255.165.260'], ['G02.300'], ['D08.811.277.450.642'], ['G02.111.679', 'G03.808'], ['D12.776'], ['D08.811.277.352.700'], ['D12.776.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of partial unfolding and aggregation of human stefin B (cystatin B) EPM1 mutants G50E and Q71P on selective cleavages by cathepsins B and S. | Human stefins and cystatins are physiologically important cysteine proteinase inhibitors, acting as a first line of defense against undesirable proteolysis. Mutations in the cystatin B gene cause a rare form of epilepsy EPM1. Its two missense mutants, G50E and Q71P, lack the inhibitory activity and are partially unfold... | ['Cathepsin B', 'Cathepsins', 'Cystatin B', 'Electrophoresis, Polyacrylamide Gel', 'Fluorescent Antibody Technique', 'Humans', 'Mutant Proteins', 'Protein Stability', 'Protein Structure, Quaternary', 'Protein Unfolding', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'Unverricht-Lundborg Syndrome'] | 23,362,198 | [['D08.811.277.656.224.125', 'D08.811.277.656.262.500.133', 'D08.811.277.656.300.200.133'], ['D08.811.277.656.224'], ['D12.776.215.200'], ['E05.196.401.402', 'E05.301.300.319'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['B01... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Study of the Prevention of Anal Cancer (SPANC): design and methods of a three-year prospective cohort study. | BACKGROUND: The incidence of human papillomavirus (HPV)-associated anal cancer is increasing in men who have sex with men (MSM). Screening for the presumed cancer precursor, high-grade anal squamous intraepithelial lesions (HSIL) in a manner analogous to cervical cancer screening has been proposed. Uncertainty remains ... | ['Adult', 'Anal Canal', 'Anus Neoplasms', 'Carcinoma, Squamous Cell', 'Early Detection of Cancer', 'HIV Seropositivity', 'Homosexuality, Male', 'Humans', 'Male', 'New South Wales', 'Papillomaviridae', 'Papillomavirus Infections', 'Prospective Studies', 'Quality of Life', 'Research Design', 'Risk Factors', 'Surveys and ... | 24,107,134 | [['M01.060.116'], ['A03.556.124.526.070', 'A03.556.249.249.070'], ['C04.588.274.476.411.307.790.040', 'C06.301.371.411.307.790.040', 'C06.405.249.411.307.790.040', 'C06.405.469.491.307.790.040', 'C06.405.469.860.101.163', 'C06.405.469.860.180.500.040'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E01.390.500'], [... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities... | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
[Computer analysis of single channel current record by extracellular patch clamp]. | Neher and Sakmann had provided the presence of the channel protein by the direct measurement of single channel current from excitable membrane in 1976. The advantage of this method "patch clamp" is to isolate a small part of membrane and pick up electrical excitability. In order to record single channel current the sea... | ['Electric Conductivity', 'Humans', 'Ion Channels', 'Signal Processing, Computer-Assisted'] | 2,484,972 | [['G01.358.500.249.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['L01.224.800']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Beta2-glycoprotein I Expression in Lupus Nephritis Patients with Antiphospholipid-associated Nephropathy. | OBJECTIVE: Antiphospholipid-associated nephropathy (aPLN) is a severe condition in patients with lupus nephritis (LN). aPLN should be distinguished from other reasons for renal ischemia. The most important cofactor of antiphospholipid antibodies (aPL), â2-glycoprotein I (â2GPI), was shown in vitro to bind endothelial c... | ['Adolescent', 'Adult', 'Antibodies, Antiphospholipid', 'Antiphospholipid Syndrome', 'Endothelial Cells', 'Female', 'Humans', 'Kidney', 'Lupus Nephritis', 'Male', 'Middle Aged', 'Retrospective Studies', 'Young Adult', 'beta 2-Glycoprotein I'] | 27,633,824 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.323.210', 'D12.776.124.790.651.114.323.210', 'D12.776.377.715.548.114.323.210'], ['C20.111.197'], ['A11.436.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419.570.363.680', 'C13.351.968.419.570.363.680', 'C17.300.480.680', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Label-free nanoUPLC-MSE based quantification of antimicrobial peptides from the leaf apoplast of Nicotiana attenuata. | BACKGROUND: Overexpressing novel antimicrobial peptides (AMPs) in plants is a promising approach for crop disease resistance engineering. However, the in planta stability and subcellular localization of each AMP should be validated for the respective plant species, which can be challenging due to the small sizes and ex... | ['Amino Acid Sequence', 'Antimicrobial Cationic Peptides', 'Chemistry Techniques, Analytical', 'Chromatography, High Pressure Liquid', 'Mass Spectrometry', 'Plant Proteins', 'Plants, Genetically Modified', 'Protein Structure, Quaternary', 'Tobacco'] | 25,604,123 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.644.050', 'D12.776.543.695.054'], ['E05.196'], ['E05.196.181.400.300'], ['E05.196.566'], ['D12.776.765'], ['B01.650.520', 'B05.620.600'], ['G02.111.570.820.709.550'], ['B01.650.940.800.575.912.250.908.500.900']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Multiplex reverse transcription PCR Luminex assay for detection and quantitation of viral agents of gastroenteritis. | BACKGROUND: Several viruses can cause diarrheal disease, a leading cause of morbidity and mortality worldwide. Existing diagnostic methods include ELISA and nucleic acid amplification, usually performed individually.OBJECTIVES: (1) To develop a multiplexed assay for simultaneous detection of major enteric viral pathoge... | ['Adenoviruses, Human', 'Diarrhea', 'Feces', 'Fluorescent Dyes', 'Gastroenteritis', 'Humans', 'Microspheres', 'RNA Viruses', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sensitivity and Specificity', 'Tanzania', 'Viral Load'] | 21,256,076 | [['B04.280.030.500.350'], ['C23.888.821.214'], ['A12.459'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['C06.405.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.565'], ['B04.820'], ['E05.393.620.500.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725',... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Segmental innervation of rotated and supernumerary axolotl hindlimbs. | The segmental nerve supply to axolotl limbs was misrouted by severing the limbs at the level of the femur, rotating them 180 degrees around their long axis, and then suturing them to the intact proximal stump. Following return of the blood supply to the rotated limb by the cross-anastomosing of blood vessels, a blastem... | ['Ambystoma', 'Ambystoma mexicanum', 'Animals', 'Cholinesterases', 'Hindlimb', 'Muscles', 'Transplantation, Autologous'] | 7,462,973 | [['B01.050.150.900.090.608.080.068'], ['B01.050.150.900.090.608.080.068.525'], ['B01.050'], ['D08.811.277.352.100.170'], ['A13.473'], ['A02.633', 'A10.690'], ['E04.936.664']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structural investigations of acridine derivatives by CoMFA and CoMSIA reveal novel insight into their structures toward DNA G-quadruplex mediated telomerase inhibition and offer a highly predictive 3D-model for substituted acridines. | Stabilization of G-quadruplex structures formed from telomeric DNA, by means of G-quadruplex selective ligands, is a means of inhibiting the telomerase enzyme. This makes G-quadruplex an emerging target for cancer therapy. The objective of the current 3D QSAR study is to uncover structural requirements for acridine der... | ['Acridines', 'DNA', 'G-Quadruplexes', 'Models, Molecular', 'Telomerase'] | 19,413,274 | [['D03.633.300.046'], ['D13.444.308'], ['G02.111.570.820.486.550', 'G05.360.580.550'], ['E05.599.595'], ['D08.811.913.696.445.308.300.750.750', 'D12.776.157.687.613', 'D12.776.157.725.500.921', 'D12.776.660.720.613', 'D12.776.664.962.500.921']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Flecainide toxicity in a neonate with supraventricular tachycardia. | Class IC antiarrhythmic drugs, specifically encainide and flecainide, have been used with increasing frequency in children and young adults with both atrial and ventricular tachyarrhythmias. As a result of the recent findings from the Cardiac Arrhythmia Suppression Trial (CAST) study, their use in adults as well as chi... | ['Electrocardiography', 'Flecainide', 'Heart Block', 'Humans', 'Infant, Newborn', 'Male', 'Tachycardia, Supraventricular'] | 1,960,074 | [['E01.370.370.380.240', 'E01.370.405.240'], ['D03.383.621.270'], ['C14.280.067.558', 'C14.280.123.500', 'C23.550.073.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C14.280.067.845.880', 'C14.280.123.875.880', 'C23.550.073.845.880']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Instantaneous Heart Rate detection using short-time autocorrelation for wearable healthcare systems. | This report describes a robust method of Instantaneous Heart Rate (IHR) detection from noisy electrocardiogram (ECG) signals. Generally, the IHR is calculated from the interval of R-waves. Then, the R-waves are extracted from the ECG using a threshold. However, in wearable biosignal monitoring systems, various noises (... | ['Algorithms', 'Artifacts', 'Computer Simulation', 'Electrocardiography, Ambulatory', 'Electrodes', 'Equipment Design', 'Exercise', 'Exercise Test', 'Heart Rate', 'Humans', 'Models, Cardiovascular', 'Models, Statistical', 'Reproducibility of Results', 'Signal Processing, Computer-Assisted'] | 23,367,467 | [['G17.035', 'L01.224.050'], ['E05.047'], ['L01.224.160'], ['E01.370.370.380.240.230', 'E01.370.405.240.230', 'E01.370.520.500.230'], ['E07.305.250'], ['E05.320'], ['G11.427.410.698.277', 'I03.350'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Experimental tooth movement temporally changes neural excitation and topographical map in rat somatosensory cortex. | During orthodontic treatment, binding teeth, may change the topographically organized representation of teeth in the cerebral cortex. To test the hypothesis that experimental tooth movement (ETM) changes the somatotopy of an individual tooth arrangement in the somatosensory cortex, we examined the spatiotemporal featur... | ['Animals', 'Brain Mapping', 'Cerebral Cortex', 'Electric Stimulation', 'Incisor', 'Male', 'Molar', 'Neuronal Plasticity', 'Nociception', 'Optical Imaging', 'Rats', 'Rats, Sprague-Dawley', 'Somatosensory Cortex', 'Tooth Mobility', 'Tooth Movement Techniques'] | 29,928,871 | [['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['E05.723.402'], ['A14.549.167.860.425'], ['A14.549.167.860.525'], ['G11.561.638'], ['F02.463.593.504.500'], ['E01.370.350.589', 'E05.642'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.15... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Automating the Paris System for urine cytopathology-A hybrid deep-learning and morphometric approach. | BACKGROUND: The Paris System for Urine Cytopathology (the Paris System) has succeeded in making the analysis of liquid-based urine preparations more reproducible. Any algorithm seeking to automate this system must accurately estimate the nuclear-to-cytoplasmic (N:C) ratio and produce a qualitative "atypia score." The a... | ['Algorithms', 'Automation', 'Cytodiagnosis', 'Deep Learning', 'Humans', 'Urinalysis'] | 30,702,803 | [['G17.035', 'L01.224.050'], ['J01.897.104'], ['E01.370.225.500.384', 'E05.200.500.384', 'E05.242.384'], ['G17.035.250.500.250', 'G17.485.500', 'L01.224.050.375.530.250', 'L01.224.050.375.605.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.124.810', 'E01.370.390.810', 'E05.200.124.810']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Regulation of NF-E2 activity in erythroleukemia cell differentiation. | The erythroid transcription factor NF-E2 is an obligate heterodimer composed of two different subunits (p45 and p18), each containing a basic region-leucine zipper DNA binding domain, and it plays a critical role in erythroid differentiation as an enhancer-binding protein for expression of the beta-globin gene. We show... | ['5-Aminolevulinate Synthetase', 'Animals', 'Calcium-Calmodulin-Dependent Protein Kinases', 'Cell Differentiation', 'DNA-Binding Proteins', 'Dimethyl Sulfoxide', 'Drug Resistance', 'Enhancer Elements, Genetic', 'Erythroid-Specific DNA-Binding Factors', 'Erythropoiesis', 'Gene Expression Regulation, Developmental', 'Gen... | 9,478,996 | [['D08.811.913.050.276'], ['B01.050'], ['D08.811.913.696.620.682.700.125', 'D12.644.360.100', 'D12.776.476.100'], ['G04.152'], ['D12.776.260'], ['D02.886.640.150'], ['G07.690.773.984'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.360.340.024.340.137.750.249'], ['D12.776.260.235', 'D12.776.930.216'], ['G04.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A pool of reversibly cell-associated cholesteryl esters involved in the selective uptake of cholesteryl esters from high-density lipoproteins by Hep G2 hepatoma cells. | Selective uptake of high-density lipoprotein (HDL) cholesteryl esters without parallel uptake of HDL apolipoproteins occurs by a non-endocytotic pathway that results in net delivery of cholesteryl esters to cells. With respect to the cellular mechanism of this pathway, previous studies with adrenal cells showed a chole... | ['Animals', 'Carcinoma, Hepatocellular', 'Cell Membrane', 'Cholesterol Esters', 'Cholesterol, HDL', 'Humans', 'Iodine Radioisotopes', 'Liver Neoplasms', 'Mice', 'Time Factors', 'Tritium', 'Trypsin', 'Tumor Cells, Cultured'] | 8,382,960 | [['B01.050'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.284.149'], ['D04.210.500.247.222.284.200', 'D04.210.500.247.808.197.200', 'D10.570.938.208.250'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['B01.050.150.... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Changes in serum anti-Helicobacter pylori IgG antibody, pepsinogen I, and pepsinogen II after eradication therapy of Helicobacter pylori]. | To investigate the changes in serum anti-Helicobacter pylori IgG antibody (HP Ab), pepsinogen I (PG I), pepsinogen II (PG II), and pepsinogen I/II ratio (PG I/II) after eradication therapy of Helicobacter pylori (HP), we studied 78 patients with HP-positive peptic diseases. They received combination therapy (proton pum... | ['Amoxicillin', 'Anti-Bacterial Agents', 'Antibodies, Bacterial', 'Clarithromycin', 'Drug Therapy, Combination', 'Female', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Immunoglobulin G', 'Male', 'Middle Aged', 'Penicillins', 'Pepsinogens', 'Peptic Ulcer', 'Proton Pump Inhibitors'] | 9,396,326 | [['D02.065.589.099.750.750.050.050', 'D02.886.108.750.750.050.050', 'D03.633.100.300.750.750.050.050'], ['D27.505.954.122.085'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D02.540.576.500.992.100'], ['E02.319.310'], ['C01.150.252.400.466'], ['B03.440.500.550', 'B03.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Venous thrombosis and tissue plasminogen activator release deficiency: a family study. | Thrombotic events are often due to fibrinolytic defects such as impaired tissue plasminogen activator (tPA) synthesis and/or release or increased plasminogen activator inhibitor (PAI) levels. In this report we describe four members of a family with a history of recurrent venous thrombosis, who demonstrated defective tP... | ['Adult', 'Constriction', 'Deamino Arginine Vasopressin', 'Female', 'Fibrinolysis', 'Humans', 'Male', 'Pedigree', 'Plasminogen', 'Thrombophlebitis', 'Tissue Plasminogen Activator', 'Veins'] | 1,909,902 | [['M01.060.116'], ['E05.225'], ['D06.472.699.631.692.781.100.250', 'D12.644.400.900.100.250', 'D12.644.456.925.100.250', 'D12.644.548.691.692.781.100.250', 'D12.776.631.650.937.100.250'], ['G09.188.390.150.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.673'], ['D08.622.610', 'D12.776.124.790.223.580'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The osteoplastic effectiveness of the implants made of mesh titanium nickelide constructs. | The purpose of the work was to study the features of reparative osteogenesis for filling the defect of tubular bone under implantation of mesh titanium nickelide constructs. Tibial fenestrated defect was modeled experimentally in 30 Wistar pubertal rats, followed by implant intramedullary insertion. The techniques of r... | ['Animals', 'Biocompatible Materials', 'Bone Remodeling', 'Bone Substitutes', 'Bone and Bones', 'Electron Probe Microanalysis', 'Female', 'Haversian System', 'Implants, Experimental', 'Male', 'Neovascularization, Physiologic', 'Nickel', 'Osseointegration', 'Osteoblasts', 'Osteogenesis', 'Rats', 'Rats, Wistar', 'Tibia',... | 24,579,962 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['G11.427.213', 'G16.762.150'], ['D25.130.325', 'J01.637.051.130.325'], ['A02.835.232', 'A10.165.265'], ['E01.370.350.515.402.250', 'E05.196.867.800.360', 'E05.595.402.250', 'E05.799.830.360'], ['A10.165.265.521.500'], ['E07.695.340'], ['G09.330.630'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Prevalence and risk factors concerning postpartum depression among women within early postnatal periods in Turkey. | PURPOSE: Postpartum depression (PPD) stands out as an important health issue that affects not only the mother but her partner and the entire family. A few studies from Turkey have found the high prevalence for PPD. In the current study we aimed: (1) to report the prevalence of postpartum depression among Turkish women ... | ['Adult', 'Delivery, Obstetric', 'Depression, Postpartum', 'Female', 'Humans', 'Male', 'Pregnancy', 'Prevalence', 'Psychiatric Status Rating Scales', 'Risk Factors', 'Social Support', 'Turkey', 'Young Adult'] | 20,191,280 | [['M01.060.116'], ['E04.520.252'], ['C13.703.844.253', 'F03.600.300.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['F04.711.513.653'], ['E05.318.740.600.800.725', 'N05.715.350... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The role of antiviral therapy in immunocompromised patients with herpes simplex virus meningitis. | BACKGROUND: Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are important causes of acute neurologic illness. Although the role of acyclovir in treating HSV encephalitis is clear, the role of antiviral therapy in HSV meningitis remains controversial.METHODS: In this retrospective observational study, we reviewed t... | ['Acyclovir', 'Adult', 'Antiviral Agents', 'Cerebrospinal Fluid', 'Encephalitis, Herpes Simplex', 'Female', 'Herpesvirus 1, Human', 'Herpesvirus 2, Human', 'Humans', 'Immunocompromised Host', 'Male', 'Middle Aged', 'Retrospective Studies', 'Treatment Outcome', 'Young Adult'] | 25,273,082 | [['D03.633.100.759.758.399.454.250'], ['M01.060.116'], ['D27.505.954.122.388'], ['A12.207.270.210'], ['C01.207.245.340.350', 'C01.207.399.750.350', 'C01.925.182.525.350', 'C01.925.256.466.262', 'C10.228.140.430.520.750.350', 'C10.228.228.245.340.350', 'C10.228.228.399.750.350'], ['B04.280.382.100.750.390'], ['B04.280.3... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Traumatic myelopathy in a seventeen-year-old child with cervical spinal stenosis (without fracture or dislocation) and a C2-C3 Klippel-Feil fusion. A case report. | A 17-year-old white male patient sustained a cervical hyperextension injury while body surfing. Plain cervical radiographs, tomography, and CAT scan showed neither fracture nor subluxation, but congenital narrowing of the spinal canal and fusion of C2-C3 (Klippel-Feil). Clinically, he had a central cord syndrome, chara... | ['Adolescent', 'Fractures, Bone', 'Humans', 'Joint Dislocations', 'Klippel-Feil Syndrome', 'Male', 'Quadriplegia', 'Spinal Cord Injuries', 'Spinal Stenosis'] | 6,474,247 | [['M01.060.057'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.518', 'C26.289'], ['C05.116.099.370.535', 'C05.660.551', 'C16.131.621.551'], ['C10.597.622.760', 'C23.888.592.636.786'], ['C10.228.854.763', 'C10.900.850', 'C26.819'], ['C05.116.900.825']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Decreased Desmin expression in the developing diaphragm of the nitrofen-induced congenital diaphragmatic hernia rat model. | PURPOSE: Congenital diaphragmatic hernia (CDH) is presumed to originate from defects in the primordial diaphragmatic mesenchyme, mainly comprising of muscle connective tissue (MCT). Thus, normal diaphragmatic morphogenesis depends on the structural integrity of the underlying MCT. Developmental mutations that inhibit n... | ['Animals', 'Desmin', 'Diaphragm', 'Disease Models, Animal', 'Female', 'Fetal Development', 'Fluorescent Antibody Technique', 'Hernias, Diaphragmatic, Congenital', 'Phenyl Ethers', 'Rats', 'Rats, Sprague-Dawley', 'Real-Time Polymerase Chain Reaction'] | 27,651,373 | [['B01.050'], ['D05.750.078.593.200', 'D12.776.220.475.200'], ['A02.633.567.900.300'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.345.500.325.235', 'G08.686.784.170.157'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren. | The protective effect of combination therapy with valsartan and aliskiren against renal fibrosis remains to be defined. This study was undertaken to examine the protective effects of the combination of valsartan and aliskiren against renal fibrosis induced by unilateral ureteral obstruction (UUO). Combination therapy w... | ['Actins', 'Amides', 'Anatomy, Cross-Sectional', 'Animals', 'Antihypertensive Agents', 'Blood Pressure', 'Blotting, Western', 'Collagen', 'Drug Therapy, Combination', 'Extracellular Signal-Regulated MAP Kinases', 'Fibrosis', 'Fumarates', 'Immunohistochemistry', 'Kidney', 'Kidney Diseases', 'Kidney Function Tests', 'Mal... | 20,685,818 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['D02.065'], ['H01.158.100.185'], ['B01.050'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D05.750.078.280', 'D12.776.86... | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Aetiologies and outcomes of diffuse alveolar haemorrhage presenting as acute respiratory failure of uncertain cause. | BACKGROUND AND OBJECTIVE: Connective tissue diseases are the most common disorders causing diffuse alveolar haemorrhage (DAH) confirmed by open lung biopsy. However, it is not known whether these diseases are also the most common causes of DAH in patients presenting with the features of ARDS/acute lung injury (ALI). Th... | ['Acute Lung Injury', 'Adult', 'Aged', 'Aged, 80 and over', 'Connective Tissue Diseases', 'Female', 'Hemorrhage', 'Humans', 'Incidence', 'Korea', 'Lung Diseases', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Prognosis', 'Respiratory Distress Syndrome', 'Retrospective Studies'] | 19,210,654 | [['C08.381.520.500'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C17.300'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['Z01.252.474.557', 'Z01.586.407'], ['C08.... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Spinal cord compression by a rheumatoid nodule. | A case, believed to be unique, is reported of spinal cord compression due to an extradural rheumatoid nodule. | ['Humans', 'Male', 'Rheumatic Nodule', 'Spinal Cord', 'Spinal Cord Compression'] | 1,206,413 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.114.843.566', 'C05.799.825.566'], ['A08.186.854'], ['C10.228.854.761', 'C26.819.678']] | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5. | We examined the agonist-dependent sequestration/internalization of dopamine D2 receptor (the long form D2L and short form D2S), which were transiently expressed in COS-7 and HEK 293 cells with or without G-protein-coupled receptor kinases (GRK2 or GRK5). Sequestration was assessed quantitatively by loss of [3H] sulpiri... | ['Animals', 'Binding Sites', 'COS Cells', 'Cyclic AMP-Dependent Protein Kinases', 'Dopamine', 'G-Protein-Coupled Receptor Kinase 2', 'G-Protein-Coupled Receptor Kinase 5', 'Gene Expression', 'Humans', 'Protein-Serine-Threonine Kinases', 'Receptor Protein-Tyrosine Kinases', 'Receptors, Dopamine D2', 'Spiperone', 'Sulpir... | 10,091,590 | [['B01.050'], ['G02.111.570.120'], ['A11.251.210.172.500', 'A11.329.228.220'], ['D08.811.913.696.620.682.700.150.125', 'D12.644.360.200.125', 'D12.776.476.200.125'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D08.811.913.696.620.682.700.364.049.200', 'D12.644.360.293.249.200', ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Routine screening for fetal limb abnormalities in the first trimester. | OBJECTIVE: We aim to determine the accuracy of first-trimester ultrasonography in detecting fetal limb abnormalities.METHODS: This is a retrospective study of all women undergoing fetal nuchal translucency (NT) assessment and detailed fetal anatomic survey in the first trimester at a single tertiary-care referral cente... | ['Adolescent', 'Adult', 'Bone Diseases, Developmental', 'China', 'Clubfoot', 'Ectromelia', 'Female', 'Humans', 'Limb Deformities, Congenital', 'Middle Aged', 'Nuchal Translucency Measurement', 'Pregnancy', 'Pregnancy Trimester, First', 'Retrospective Studies', 'Sensitivity and Specificity', 'Syndactyly', 'Tertiary Care... | 26,573,084 | [['M01.060.057'], ['M01.060.116'], ['C05.116.099'], ['Z01.252.474.164'], ['C05.330.488.655.063', 'C05.330.495.681.063', 'C05.660.585.512.380.813.063', 'C16.131.621.585.512.500.681.063'], ['C05.660.585.350', 'C16.131.621.585.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.660.585', 'C16.131.621.585'], ['M0... | ['Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Microfilariae in fine needle aspirates from epididymal lesions. | Microfilariae of Wuchereria bancrofti were observed in fine needle aspiration smears from three epididymal nodules, and degenerating microfilariae suggestive of Brugia malayi were found in the smears from a fourth case. The smears in all four cases showed a polymorphonuclear inflammatory cell component as well as epith... | ['Adolescent', 'Adult', 'Elephantiasis, Filarial', 'Epididymis', 'Humans', 'Larva', 'Lymphedema', 'Male', 'Testicular Diseases'] | 3,468,719 | [['M01.060.057'], ['M01.060.116'], ['C01.610.335.508.700.750.361.350', 'C01.920.750', 'C15.604.496.490'], ['A05.360.444.371'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B05.500.500', 'G07.345.500.550.500.500'], ['C15.604.496'], ['C12.294.829', 'C19.391.829']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Clinical outcomes of children treated with intravenous prochlorperazine for migraine in a pediatric emergency department. | BACKGROUND: Prochlorperazine is the only treatment that has been studied so far in a randomized controlled trial and found to reduce pain at 1 h in children with migraine who presented to an emergency department (ED).OBJECTIVE: To evaluate the rate of treatment failure associated with prochlorperazine used in children ... | ['Adolescent', 'Child', 'Diphenhydramine', 'Dopamine Antagonists', 'Drug Therapy, Combination', 'Emergency Service, Hospital', 'Female', 'Humans', 'Hypnotics and Sedatives', 'Infusions, Intravenous', 'Male', 'Medical Audit', 'Migraine Disorders', 'Pain Measurement', 'Prochlorperazine', 'Retrospective Studies', 'Treatme... | 19,150,192 | [['M01.060.057'], ['M01.060.406'], ['D02.092.471.320', 'D02.455.426.559.389.115.250'], ['D27.505.519.625.150.175', 'D27.505.696.577.150.175'], ['E02.319.310'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.277.350', 'D27.505.954... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ultrasound cystourethrography by perineal scanning for the assessment of female stress urinary incontinence. | Perineal scanning using linear array ultrasound was used as an alternative to radiologic cystourethrography in the investigation of female urinary incontinence. The technique provides similar information to that obtained by fluoroscopy without exposing the patient and the physician to radiation. The bladder neck and ur... | ['Female', 'Fluoroscopy', 'Humans', 'Ultrasonography', 'Urinary Catheterization', 'Urinary Incontinence, Stress', 'Urodynamics', 'Urography'] | 3,526,217 | [['E01.370.350.700.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.850'], ['E01.370.390.820', 'E02.148.947', 'E05.157.500'], ['C12.777.934.852.249', 'C13.351.968.934.814.500', 'C23.888.942.343.800.500'], ['G08.852.898'], ['E01.370.350.700.830', 'E01.370.390.830']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny. | Mitochondrial DNA (mtDNA) somatic mutations have been identified in nearly all kinds of cancer during the past decade. Normally one need to determine the complete mtDNA sequences from both cancerous and normal tissues of the same patient to score the somatic mutation in cancer. In this study, we intended to explore a s... | ['Adult', 'Aged', 'DNA, Mitochondrial', 'DNA, Neoplasm', 'Female', 'Genetic Techniques', 'Humans', 'Male', 'Middle Aged', 'Mutation', 'Phylogeny', 'Stomach Neoplasms'] | 21,419,139 | [['M01.060.116'], ['M01.060.116.100'], ['D13.444.308.283.225'], ['D13.444.308.425'], ['E05.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G05.365.590'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Role of two essential domains of Escherichia coli FtsA in localization and progression of the division ring. | The FtsA protein is a member of the actin superfamily that localizes to the bacterial septal ring during cell division. Deletions of domain 1C or the S12 and S13 beta-strands in domain 2B of the Escherichia coli FtsA, previously postulated to be involved in dimerization, result in partially active proteins that do not ... | ['Cell Division', 'Cell Shape', 'Escherichia coli', 'Escherichia coli Proteins', 'Models, Molecular', 'Protein Structure, Tertiary', 'Two-Hybrid System Techniques'] | 15,387,815 | [['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.320'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['E05.599.595'], ['G02.111.570.820.709.610'], ['E05.393.220.870', 'E05.601.690.650', 'E05.601.870']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Historical review of pandemic influenza A in Taiwan, 2009. | Influenza is an important disease in children. In April 2009, human infections caused by a novel swine H1N1 virus were reported in Mexico, followed by a pandemic. As of 14 March 2010, more than 213 countries and overseas territories or communities have reported laboratory-confirmed cases of pandemic influenza H1N1 2009... | ['Disease Outbreaks', 'History, 15th Century', 'History, 20th Century', 'Humans', 'Influenza A Virus, H1N1 Subtype', 'Influenza Vaccines', 'Influenza, Human', 'Taiwan', 'Vaccination'] | 20,417,458 | [['N06.850.290'], ['K01.400.475.500'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B04.820.480.968.405.400.214'], ['D20.215.894.899.302'], ['C01.748.310', 'C01.925.782.620.365', 'C08.730.310'], ['Z01.252.474.872', 'Z01.639.850'], ['E02.095.465.425.400.530.890', 'E05.478.550.600.890', 'N02.42... | ['Health Care [N]', 'Humanities [K]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease. | Two recent genome-wide association studies in Asians have reported the association between the PSCA (prostate stem cell antigen) rs2294008C>T gene polymorphism and two Helicobacter pylori infection-related diseases such as gastric cancer (GC) and duodenal ulcer (DU). Since rs2294008 allele frequencies differ notably am... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Alleles', 'Antigens, Neoplasm', 'Case-Control Studies', 'Duodenal Ulcer', 'European Continental Ancestry Group', 'Female', 'GPI-Linked Proteins', 'Genetic Predisposition to Disease', 'Genome-Wide Association Study', 'Helicobacter Infections', 'Helicobacter pylori', ... | 25,721,731 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G05.360.340.024.340.030'], ['D23.050.285'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C06.405.469.275.800.348', 'C06.405.748.586.349'], ['M01.686.508.400'], ['D12.776.395.550.448', 'D12.776.543.484.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A simple duplex-PCR protocol for routine diagnosis and follow up of canine leishmaniasis. | The introduction of PCR has efficiently improved diagnosis of canine leishmaniasis. In order to provide a robust, efficient and reliable diagnostic method, a duplex PCR assay targeting the Leishmania infantum kDNA minicircle and the canine GAPDH gene as inner control was designed. Sensitivity of the assay reached 0.15 ... | ['Allopurinol', 'Animals', 'Antiprotozoal Agents', 'DNA, Kinetoplast', 'Dog Diseases', 'Dogs', 'Drug Therapy, Combination', 'Female', 'Leishmania infantum', 'Leishmaniasis, Visceral', 'Lymph Nodes', 'Lymphadenitis', 'Male', 'Meglumine', 'Meglumine Antimoniate', 'Organometallic Compounds', 'Parasitemia', 'Phosphoric Mon... | 18,412,042 | [['D03.633.100.759.160'], ['B01.050'], ['D27.505.954.122.250.100'], ['D13.444.308.283.225.200', 'D13.444.308.442.200'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['E02.319.310'], ['B01.268.475.868.488.325'], ['C01.610.752.300.500.510', 'C01.920.813.510'], ['A10.549.400', 'A15.382.520.604.412'], ['C15.60... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Model-based derivation, analysis and control of unstable microaerobic steady-states--considering Rhodospirillum rubrum as an example. | Microaerobic (oxygen-limited) conditions are critical for inducing many important microbial processes in industrial or environmental applications. At very low oxygen concentrations, however, the process performance often suffers from technical limitations. Available dissolved oxygen measurement techniques are not sensi... | ['Aerobiosis', 'Bioreactors', 'Cell Culture Techniques', 'Models, Biological', 'Oxygen', 'Reproducibility of Results', 'Rhodospirillum rubrum', 'Systems Biology'] | 24,285,380 | [['G02.111.017', 'G03.049'], ['E07.115', 'J01.897.120.115'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['E05.599.395'], ['D01.268.185.550', 'D01.362.670'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['B03.440.400.425.708.733.650', 'B03.660.050.7... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Bim deficiency leads to exacerbation and prolongation of joint inflammation in experimental arthritis. | OBJECTIVE: : Rheumatoid arthritis (RA) is characterized by hyperplasia of the synovial lining, inflammation, and destruction of cartilage and bone. Since there are only a few detectable cells undergoing apoptosis in the joint, it is possible that a defect in apoptosis may contribute to synovial hyperplasia. This study ... | ['Animals', 'Ankle Joint', 'Apoptosis', 'Apoptosis Regulatory Proteins', 'Arthritis, Rheumatoid', 'Bcl-2-Like Protein 11', 'Disease Models, Animal', 'Gene Expression Regulation', 'Interleukin-1beta', 'Membrane Proteins', 'Mice', 'Mice, Knockout', 'Myeloid Cell Leukemia Sequence 1 Protein', 'Neoplasm Proteins', 'Proto-O... | 17,009,248 | [['B01.050'], ['A02.835.583.378.062'], ['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D12.644.360.075.323', 'D12.776.476.075.323', 'D12.776.543.116', 'D12.776.624.664.700.025'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.308... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cerebrospinal fluid high mobility group box 1 is associated with neuronal death in subarachnoid hemorrhage. | We aim to determine the cerebrospinal fluid levels of high mobility group box 1 in subarachnoid hemorrhage patients and to investigate the involvement of the receptor for advanced glycation end products and high mobility group box 1 in the pathogenesis of post-subarachnoid hemorrhage neuronal death. The study included ... | ['Adult', 'Aged', 'Animals', 'Brain', 'Cell Death', 'Cells, Cultured', 'Female', 'Glycation End Products, Advanced', 'HMGB1 Protein', 'Humans', 'Male', 'Middle Aged', 'Neurons', 'Prognosis', 'Rats, Wistar', 'Receptor for Advanced Glycation End Products', 'Recombinant Proteins', 'Subarachnoid Hemorrhage'] | 26,823,474 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050'], ['A08.186.211'], ['G04.146'], ['A11.251'], ['D12.776.643.500'], ['D12.776.260.356.300', 'D12.776.660.235.400.600.300', 'D12.776.664.235.400.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A08.675', 'A11.671'], ['E01.789'], ['B01.050.... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Treatment-related reductions in PTSD and changes in physical health symptoms in women. | This study examined the relationship between change in posttraumatic stress disorder (PTSD) symptoms over the course of PTSD treatment and the association with changes in general physical health symptoms. Both positive health habits (e.g., exercise) and negative (e.g., smoking), were examined to determine if they accou... | ['Adult', 'Cognitive Behavioral Therapy', 'Female', 'Habits', 'Health Behavior', 'Health Status', 'Humans', 'Middle Aged', 'Stress Disorders, Post-Traumatic', 'Treatment Outcome'] | 23,471,544 | [['M01.060.116'], ['F04.754.137.350'], ['F01.145.466'], ['F01.145.488'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F03.950.750.500'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Acoustic characteristics of vowels by normal Malaysian Malay young adults. | The acoustic characteristics of sustained vowel have been widely investigated across various languages and ethnic groups. These acoustic measures, including fundamental frequency (F(0)), jitter (Jitt), relative average perturbation (RAP), five-point period perturbation quotient (PPQ5), shimmer (Shim), and 11-point ampl... | ['Asian Continental Ancestry Group', 'Female', 'Humans', 'Malaysia', 'Male', 'Phonetics', 'Sex Characteristics', 'Speech Acoustics', 'Young Adult'] | 21,429,707 | [['M01.686.508.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.145.487'], ['L01.559.598.518'], ['G08.686.815'], ['G11.561.812.650', 'G11.561.820'], ['M01.060.116.815']] | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 |
Novel polystyrene microspheres functionalized by imidazolium and the electrocatalytic activity towards H₂O₂ of its Prussian blue composite. | Copolymerization of styrene (St) and 1-vinyl-3-ethylimidazolium bromide (VEIB), novel poly(St-co-VEIB) microspheres were generated. Owing to the presence of imidazolium groups, such microspheres having an average diameter of 125 nm, behave electropositively when dispersed in aqueous solution. Furthermore, due to the pr... | ['Catalysis', 'Electromagnetic Fields', 'Ferrocyanides', 'Hydrogen Peroxide', 'Imidazoles', 'Imidazolines', 'Materials Testing', 'Microspheres', 'Polystyrenes'] | 23,619,536 | [['G02.130'], ['G01.358.500.260', 'G01.358.750.500'], ['D01.248.497.158.291.370', 'D01.490.200.250', 'D01.625.400.100.350'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['D03.383.129.308'], ['D03.383.129.308.436'], ['E05.570'], ['E07.565'], ['D02.455.426.559.389.150... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Fusion of an oligopeptide to the N terminus of an alkaline á-amylase from Alkalimonas amylolytica simultaneously improves the enzyme's catalytic efficiency, thermal stability, and resistance to oxidation. | In this study, we constructed and expressed six fusion proteins composed of oligopeptides attached to the N terminus of the alkaline á-amylase (AmyK) from Alkalimonas amylolytica. The oligopeptides had various effects on the functional and structural characteristics of AmyK. AmyK-p1, the fusion protein containing pepti... | ['Amino Acid Sequence', 'Bacterial Proteins', 'Biocatalysis', 'Detergents', 'Enzyme Stability', 'Gammaproteobacteria', 'Gene Expression', 'Half-Life', 'Hot Temperature', 'Hydrogen Peroxide', 'Hydrogen-Ion Concentration', 'Kinetics', 'Models, Structural', 'Molecular Dynamics Simulation', 'Molecular Sequence Data', 'Olig... | 23,455,344 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['G02.111.086', 'G02.130.500', 'G03.105'], ['D27.720.877.265', 'J01.516.381'], ['E05.916.360', 'G02.111.700.500'], ['B03.660.250'], ['G05.297'], ['G01.910.405'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
[Characteristic of ocular safety profile of triamcinolone made in China]. | OBJECTIVE: To characterize the safety profile of triamcinolone acetonide made in China (Transton) and triamcinolone acetonide acetate (Tongyong) for their ocular application.METHODS: Experimental study. In vitro cell viability assay was performed on 3 types of human ocular cells to evaluate the cytotoxicity of the simu... | ['Animals', 'Cell Survival', 'China', 'Electroretinography', 'Fibroblasts', 'Glucocorticoids', 'Guinea Pigs', 'Humans', 'Intraocular Pressure', 'Intravitreal Injections', 'Ophthalmoscopy', 'Rabbits', 'Random Allocation', 'Retina', 'Retinal Pigment Epithelium', 'Tonometry, Ocular', 'Triamcinolone Acetonide', 'Vision, Oc... | 25,312,463 | [['B01.050'], ['G04.346'], ['Z01.252.474.164'], ['E01.370.380.225', 'E01.370.405.270'], ['A11.329.228'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['B01.050.150.900.649.313.992.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['E02.319.267.530.475.500'], ['E01.370.380.560'], ['B01.050.150.900.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Intermediate frequency magnetic field and chick embryotoxicity. | Intermediate frequency magnetic fields (MFs) have widely been used in industrial machines and home appliances, such as induction heating cookers, although toxicity studies to evaluate the potential health risks of such fields are insufficient. In induction heating cookers, the MF source (i.e. hobs), is located near the... | ['Animals', 'Chick Embryo', 'Chickens', 'Congenital Abnormalities', 'Embryonic Development', 'Fetal Death', 'Magnetic Fields', 'Time Factors'] | 23,998,264 | [['B01.050'], ['A13.350.150', 'A16.331.200'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['C16.131'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['C13.703.223', 'C23.550.260.585'], ['G01.358.750'], ['G01.910.857']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preload dependence of Doppler-derived indexes of left ventricular diastolic function in humans. | To determine the effect of filling pressure on the pattern of left ventricular filling in humans, the mitral flow velocity profile was measured by pulsed wave Doppler echocardiography during right and left heart catheterization in 11 patients before and during nitroglycerin infusion. Nitroglycerin reduced mean arterial... | ['Adult', 'Aged', 'Blood Flow Velocity', 'Cardiac Catheterization', 'Diastole', 'Echocardiography', 'Female', 'Heart', 'Heart Ventricles', 'Hemodynamics', 'Humans', 'Male', 'Middle Aged', 'Mitral Valve', 'Myocardial Contraction', 'Nitroglycerin', 'Pressure', 'Rheology'] | 2,958,532 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['A07.541'], ['A07.541.560'], ['G09.330.380'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Seven new species of the genus <i>Xestoleberis</i> (Ostracoda: Podocopida: Cytheroidea) from the Fiji Archipelago. | The genus Xestoleberis has a global distribution, and although they are predominant in shallow marine environments adapted to both sediment and algal habitats, only two species of this genus, Xestoleberis curta (Brady, 1866) and Xestoleberis variegata Brady, 1880, have previously been reported from the Fiji archipelago... | ['Animal Distribution', 'Animals', 'Crustacea', 'Ecosystem', 'Female', 'Fiji', 'Male', 'Microscopy, Electron, Scanning'] | 28,006,811 | [['F01.145.113.069', 'G16.049'], ['B01.050'], ['B01.050.500.131.365'], ['G16.500.275.157', 'N06.230.124'], ['Z01.639.760.590.373'], ['E01.370.350.515.402.541', 'E05.595.402.541']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain. | Dual-specificity protein phosphatases (DSPs) dephosphorylate proteins at Ser/Thr and Tyr. FYVE domain is a double zinc finger motif which specifically binds phosphatidylinositol(3)-phosphate. Here, we report a novel dual specificity phosphatase that contains a FYVE domain at the C-terminus. We designate the protein FYV... | ['Alternative Splicing', 'Amino Acid Sequence', 'Cell Compartmentation', 'Cells, Cultured', 'Cloning, Molecular', 'Conserved Sequence', 'Humans', 'Isoenzymes', 'Molecular Sequence Data', 'Protein Structure, Tertiary', 'Protein Tyrosine Phosphatases', 'Protein Tyrosine Phosphatases, Non-Receptor', 'Sequence Analysis, DN... | 10,733,931 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G04.128'], ['A11.251'], ['E05.393.220'], ['G02.111.570.580'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['L01.453.245.667'], ['G02.111.570.820.709.610'], ['D08.811... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cognitive and serotonergic vulnerability to depression: convergent findings. | Cognitive reactivity (CR) is a psychological vulnerability marker of depression, whereas response to acute tryptophan depletion (ATD; a serotonergic challenge procedure) is a biological vulnerability marker. The aim of this study was to investigate the relationship between these markers. Thirty-nine remitted depressed ... | ['Adult', 'Cognition Disorders', 'Cross-Over Studies', 'Depression', 'Double-Blind Method', 'Female', 'Humans', 'Male', 'Personality Disorders', 'Serotonin', 'Tryptophan'] | 17,324,019 | [['M01.060.116'], ['F03.615.250'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['F01.145.126.350'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.675'], ['D02.092.211.215.801.852', 'D03.633.100.473.914.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Gas-phase peptide fragmentation: how understanding the fundamentals provides a springboard to developing new chemistry and novel proteomic tools. | This tutorial provides an overview of the evolution of some of the key concepts in the gas-phase fragmentation of different classes of peptide ions under various conditions [e.g. collision-induced dissociation (CID) and electron transfer dissociation (ETD)], and then demonstrates how these concepts can be used to devel... | ['Amino Acids', 'Cations', 'Disulfides', 'Electrons', 'Free Radicals', 'Gas Chromatography-Mass Spectrometry', 'Metals', 'Peptides', 'Phenylalanine', 'Proteomics'] | 18,819,114 | [['D12.125'], ['D01.248.497.300'], ['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['G01.249.335', 'G01.358.500.750'], ['D01.339', 'D02.389'], ['E05.196.181.349.500', 'E05.196.566.500'], ['D01.552'], ['D12.644'], ['D12.125.072.050.685', 'D12.125.142.666'], ['H01.158.201.843', 'H01.158.273.180.350... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of single-chain variable fragments (scFv) against influenza virus targeting hemagglutinin subunit 2 (HA2). | Influenza A viruses (IAV) are widespread in birds and domestic poultry, occasionally causing severe epidemics in humans and posing health threats. Hence, the need to develop a strategy for prophylaxis or therapy, such as a broadly neutralizing antibody against IAV, is urgent. In this study, single-chain variable fragme... | ['Antibodies, Neutralizing', 'Antibody Specificity', 'Hemagglutinin Glycoproteins, Influenza Virus', 'Humans', 'Immunoglobulin Fc Fragments', 'Influenza A Virus, H1N1 Subtype', 'Influenza A Virus, H3N2 Subtype', 'Influenza A Virus, H5N1 Subtype', 'Influenza, Human', 'Single-Chain Antibodies'] | 26,446,888 | [['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['G12.100'], ['D12.776.964.970.880.345.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.541.500.697', 'D12.776.124.486.485.538.500', 'D12.776.124.486.485.680.697', 'D12.776.124.790.651.538.500', 'D12.776.124... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis of the suspected trans-11,cis-13 conjugated linoleic acid isomer in ruminant mammary tissue by FADS3-catalyzed Ä13-desaturation of vaccenic acid. | The octadecadienoic conjugated linoleic acid (CLA) isomer with trans-11 and cis-13 double bonds (trans-11,cis-13 CLA) has been described in ruminant milk. For now, this specific CLA is suspected to derive exclusively from ruminal biohydrogenation of dietary á-linolenic acid. However, in rodents, the fatty acid desatura... | ['Animal Feed', 'Animals', 'Cattle', 'Diet', 'Epithelial Cells', 'Fatty Acid Desaturases', 'Female', 'Goats', 'Isomerism', 'Linoleic Acids, Conjugated', 'Mammary Glands, Animal', 'Milk', 'Oleic Acids', 'RNA, Messenger', 'Stearoyl-CoA Desaturase', 'alpha-Linolenic Acid'] | 27,865,506 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G07.203.650.240'], ['A11.436'], ['D08.811.682.690.708.392'], ['B01.050.150.900.649.313.500.380.513'], ['G02.111.570.685', 'G02.607.445'], ['D10.251.355.343.500.750'], ['A10.336.482', 'A13.589'], ['A12.200.455', 'A12.790... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Primary cutaneous mucormycosis with a Mucor species: is iron overload a factor? | A severely debilitated patient showed primary cutaneous mucormycosis with a Mucor species at a tape erosion site. The pathogenic nature and epidemiologic features of this unusual fungal infection are reviewed to emphasize its recognition in the differential diagnosis of ischemic lesions in immunocompromised patients. I... | ['Dermatomycoses', 'Female', 'Humans', 'Iron', 'Middle Aged', 'Mucormycosis', 'Risk Factors'] | 7,805,414 | [['C01.150.703.302', 'C01.800.200', 'C17.800.838.208'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['M01.060.116.630'], ['C01.150.703.980.600'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Limits of selection against cheaters: birds prioritise visual fruit advertisement over taste. | The concept of biological markets aims to explain how organisms interact with each other. Market theory predicts that organisms choose the most rewarding partner in mutualisms. However, partner choice may also be influenced by advertisement which may not be reliable. In seed dispersal mutualism, we analysed whether see... | ['Animals', 'Choice Behavior', 'Color', 'Cues', 'Diet', 'Fruit', 'Linear Models', 'Passeriformes', 'Sambucus', 'Seed Dispersal', 'Taste'] | 24,390,478 | [['B01.050'], ['F02.463.785.373.346'], ['G01.590.540.199'], ['F02.463.425.234'], ['G07.203.650.240'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Testing hypotheses regarding the causes of comorbidity: examining the underlying deficits of comorbid disorders. | The authors examined the validity of a method commonly used to test alternative hypotheses regarding the causes of comorbidity: the examination of underlying deficits of comorbid disorders. The authors simulated data in which the true causes of comorbidity were known, then compared the patterns of underlying deficits o... | ['Adult', 'Attention Deficit Disorder with Hyperactivity', 'Causality', 'Child', 'Comorbidity', 'Computer Simulation', 'Dyslexia', 'Humans', 'Mental Disorders', 'Models, Statistical', 'Risk Factors', 'Statistics as Topic'] | 16,117,572 | [['M01.060.116'], ['F03.625.094.150'], ['N05.715.350.200', 'N06.850.490.625'], ['M01.060.406'], ['N05.715.350.225', 'N06.850.490.687'], ['L01.224.160'], ['C10.597.606.150.500.300', 'C10.597.606.150.550.200', 'C23.888.592.604.150.500.300', 'C23.888.592.604.150.550.200', 'F03.625.562.400'], ['B01.050.150.900.649.313.988.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Syntaxin-3 and syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell lines. | AIMS/HYPOTHESIS: Syntaxin-1A (Syn-1A) is known to play a negative regulatory role in insulin secretion but the precise mechanisms for its action are not clear. Syn-2, -3 and -4 are also present in islet beta cells but their functions are not known. Here, we investigated the role of these syntaxins in the insulin secret... | ['Animals', 'Antigens, Surface', 'Calcium Channel Blockers', 'Calcium Channels, L-Type', 'Cell Line', 'DNA Primers', 'Exocytosis', 'Insulin', 'Insulin Secretion', 'Islets of Langerhans', 'Membrane Proteins', 'Mice', 'Nerve Tissue Proteins', 'Patch-Clamp Techniques', 'Promoter Regions, Genetic', 'Qa-SNARE Proteins', 'Ra... | 11,935,155 | [['B01.050'], ['D23.050.301'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['D12.776.157.530.400.150.400', 'D12.776.543.550.450.150.400', 'D12.776.543.585.400.150.400'], ['A11.251.210'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G04.468'], ['D06.472.699.587.200.500.625', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Physicochemical investigations of biogenic chitosan-silver nanocomposite as antimicrobial and anticancer agent. | Chitosan (CS), a seaweed polysaccharide is a natural macromolecule which is widely being used in medical applications because of its distinctive antimicrobial and anticancer properties. Silver, a noble metal, is also receiving wide attention for its potential usage in antimicrobial and anticancer therapeutics. In this ... | ['Anti-Infective Agents', 'Antineoplastic Agents', 'Bacteria', 'Cell Line, Tumor', 'Chitosan', 'Drug Screening Assays, Antitumor', 'Humans', 'Nanocomposites', 'Neoplasms', 'Silver'] | 27,381,584 | [['D27.505.954.122'], ['D27.505.954.248'], ['B03'], ['A11.251.210.190', 'A11.251.860.180'], ['D05.750.078.139.500', 'D09.698.211.500'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.637.512.150'], ['C04'], ['D01.268.556.812', 'D01.26... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p. | BACKGROUND: Clear cell renal cell carcinoma (CCRCC) is characterized by a highly metastatic potential. The stromal communication between stem cells and cancer cells critically influences metastatic dissemination of cancer cells.METHODS: The effect of exosomes isolated from cancer stem cells (CSCs) of CCRCC patients on ... | ['Animals', 'Antigens, CD', 'Biological Transport', 'Biomarkers, Tumor', 'Carcinoma, Renal Cell', 'Cell Communication', 'Cell Line, Tumor', 'Cell Proliferation', 'Epithelial-Mesenchymal Transition', 'Exosomes', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Integrin alpha Chains', 'Kidney Neoplasms', 'L... | 30,975,145 | [['B01.050'], ['D23.050.301.264.035', 'D23.101.100.110'], ['G03.143'], ['D23.101.140'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['G04.085'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.34... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Electron microscopic study of the vacuolar system of the granular cells of the frog bladder under the effect of the antidiuretic hormone]. | The ultrastructure of the vacuolar system of the frog urinary bladder epithelium has been studied under the influence of an antidiuretic hormone (ADH). It has been shown that large vacuoles of irregular form appear during the water stimulation. In some cases, the vacuole reservoirs are continuous with the electron dens... | ['Animals', 'Epithelium', 'Microscopy, Electron', 'Organoids', 'Rana temporaria', 'Urinary Bladder', 'Vacuoles', 'Vasopressins'] | 6,979,120 | [['B01.050'], ['A10.272'], ['E01.370.350.515.402', 'E05.595.402'], ['A10.802'], ['B01.050.150.900.090.180.708.420'], ['A05.810.890'], ['A11.284.430.214.190.875.190.920'], ['D06.472.699.631.692.781', 'D12.644.400.900', 'D12.644.456.925', 'D12.644.548.691.692.781', 'D12.776.631.650.937']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A pleiotropic mutation affecting purine metabolism in Bacillus subtilis. | A pleiotropic mutation (cpm) which is localized in the vicinity of the spoOA gene is described in Bacillus subtilis. The mutation inhibits spore formation, rendering bacteria auxotrophic for adenine and tyrosine, enhances sensitivity to antibiotics, decreases cell motility, inhibits the ability to grow on pentoses and ... | ["5'-Nucleotidase", 'Bacillus subtilis', 'Inosine', 'Mutation', 'Purine-Nucleoside Phosphorylase', 'Purines', 'Spores, Bacterial'] | 2,126,515 | [['D08.811.277.352.650.600.600'], ['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D03.633.100.759.590.616', 'D13.570.583.616', 'D13.570.800.573'], ['G05.365.590'], ['D08.811.913.400.725.800'], ['D03.633.100.759'], ['A... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of nitrendipine (NIT) on maternal and fetal blood pressure, uterine blood flow, and blood gas status in pregnant sheep. | Ewes of between 126-134 days of gestation (term 147 days) were anesthetized and underwent vascular cannula placement in the maternal and fetal jugular vein and carotid artery. A flow probe was placed around the uterine artery supplying the pregnant horn. A median of 7 days after surgery, the effect of nitrendipine (NIT... | ['Animals', 'Blood Gas Analysis', 'Blood Pressure', 'Female', 'Fetus', 'Heart Rate', 'Nitrendipine', 'Pregnancy', 'Regional Blood Flow', 'Sheep', 'Uterus'] | 2,468,895 | [['B01.050'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A16.378'], ['E01.370.600.875.500', 'G09.330.380.500'], ['D03.383.725.203.590'], ['G08.686.784.769'], ['G09.330.100.780'], ['B01.050.150.900.649.313.500.380.791'], ['A05.360.319.679']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Design and one-pot and microwave-assisted synthesis of 2-amino/5-aryl-1,3,4-oxadiazoles bearing a benzimidazole moiety as antioxidants. | In this study, two new series of 2-amino-1,3,4-oxadiazoles and 5-aryl-1,3,4-oxadiazoles carrying a benzimidazole moiety were synthesized. The antioxidant properties of these compounds were investigated in vitro by the determination of the microsomal NADPH-dependent inhibition of lipid peroxidation levels (LP), the micr... | ['Animals', 'Antioxidants', 'Benzimidazoles', 'Biphenyl Compounds', 'Crystallography, X-Ray', 'Cytochrome P-450 CYP1A1', 'Drug Design', 'Free Radicals', 'In Vitro Techniques', 'Lipid Peroxidation', 'Male', 'Microsomes, Liver', 'Microwaves', 'Molecular Structure', 'Oxadiazoles', 'Picrates', 'Rats', 'Rats, Wistar', 'Stru... | 22,467,524 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D03.633.100.103'], ['D02.455.426.559.389.185'], ['E05.196.309.742.225'], ['D08.244.453.005.332', 'D08.244.453.100.500', 'D08.811.682.690.708.170.010.277', 'D08.811.682.690.708.170.020.500', 'D12.776.422.220.453.010.332', 'D12.776.422.220.453... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nitric oxide synthase localization in cultured cerebrovascular endothelium during mitosis. | Nitric oxide synthase (NOS) is present in cultured endothelial cells of cerebrovascular origin in a unique membrane-bound subcellular distribution. The enzyme can be detected by its ability to reduce nitro blue tetrazolium to an insoluble dense blue formazan precipitate. In resting cells, enzyme is located adjacent to ... | ['Amino Acid Oxidoreductases', 'Animals', 'Brain', 'Cattle', 'Cells, Cultured', 'Cytoplasm', 'Endothelium, Vascular', 'Golgi Apparatus', 'Microtubules', 'Mitosis', 'Nitric Oxide Synthase', 'Spindle Apparatus', 'Subcellular Fractions'] | 7,511,538 | [['D08.811.682.664.500'], ['B01.050'], ['A08.186.211'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['A11.284.430.214'], ['A07.015.700.500', 'A10.272.491.355'], ['A11.284.430.214.190.875.336'], ['A11.284.430.214.190.750.602'], ['G04.144.220.220.781', 'G05.113.220.781'], ['D08.811.682.664.500.772'], ['A11.284.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fibronectin assembly during early embryo development: A versatile communication system between cells and tissues. | BACKGROUND: Fibronectin extracellular matrix is essential for embryogenesis. Its assembly is a cell-mediated process where secreted fibronectin dimers bind to integrin receptors on receiving cells, which actively assemble fibronectin into a fibrillar matrix. During development, paracrine communication between tissues i... | ['Animals', 'Autocrine Communication', 'Avian Proteins', 'Chick Embryo', 'Embryo, Mammalian', 'Embryonic Development', 'Extracellular Matrix', 'Fibronectins', 'Mice', 'Paracrine Communication'] | 26,845,241 | [['B01.050'], ['G04.085.100'], ['D12.776.095'], ['A13.350.150', 'A16.331.200'], ['A16.254'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['A11.284.295.310'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['B01.050.150.900.649.313.992.635.505.500'], ['G04.085.600']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sex-related severity of inflammation in parenchymal brain cysticercosis. | To determine sex-related differences in the severity of host inflammatory reaction to cysticercosis, we studied computed tomographic findings in 100 patients with parenchymal neurocysticercosis and cerebrospinal fluid results in 239 patients with subarachnoid neurocysticercosis. Computed tomographic and cerebrospinal f... | ['Cysticercosis', 'Encephalitis', 'Female', 'Humans', 'Male', 'Prognosis', 'Risk', 'Sex Factors', 'Tomography, X-Ray Computed'] | 3,341,855 | [['C01.610.335.190.902.185'], ['C10.228.140.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700', 'N06.850.520.830.600.800'], ['N05.715.350.675', 'N06.850.490.875'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.7... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Mapping of a novel gene for familial hypertrophic cardiomyopathy to chromosome 11. | Familial hypertrophic cardiomyopathy (FHC) is a cardiac disorder transmitted as an autosomal dominant trait. FHC has been shown to be genetically heterogeneous with less than 50% of published pedigrees being associated with mutations in the beta myosin heavy chain (beta-MHC) gene on chromosome 14q11-q12. A second locus... | ['Cardiomyopathy, Hypertrophic', 'Chromosome Mapping', 'Chromosomes, Human, Pair 11', 'DNA, Satellite', 'Female', 'Genetic Linkage', 'Genetic Markers', 'Humans', 'Male', 'Oligodeoxyribonucleotides', 'Pedigree', 'Polymorphism, Genetic', 'Repetitive Sequences, Nucleic Acid'] | 8,358,441 | [['C14.280.238.100', 'C14.280.484.048.750.070.160'], ['E05.393.183'], ['A11.284.187.520.300.325.355', 'G05.360.162.520.300.325.355'], ['D13.444.308.480', 'G02.111.570.080.708.800.150', 'G05.360.080.708.800.150', 'G05.360.340.024.220.150', 'G05.360.340.024.850.150'], ['G05.348'], ['D23.101.387', 'G05.695.450'], ['B01.05... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.