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Fibroblast growth factor stimulates the proliferation and differentiation of neural precursor cells in vitro. | We have developed an in vitro culture system to study the regulation of proliferation and differentiation of neural precursor cells contained within the neuroepithelium of embryonic day 10 mice. A number of soluble growth factors have been tested for their ability to regulate these early events and, of these factors, w... | ['Animals', 'Brain', 'Cell Differentiation', 'Cell Division', 'Cells, Cultured', 'Embryo, Mammalian', 'Fibroblast Growth Factors', 'Glial Fibrillary Acidic Protein', 'Intermediate Filament Proteins', 'Mice', 'Mice, Inbred CBA', 'Neurofilament Proteins', 'Stem Cells', 'Thymidine'] | 2,112,611 | [['B01.050'], ['A08.186.211'], ['G04.152'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['A16.254'], ['D12.644.276.624', 'D12.776.467.624', 'D23.529.624'], ['D05.750.078.593.400', 'D12.776.220.475.400'], ['D05.750.078.593', 'D12.776.220.475'], ['B01.050.150.900.649.313.992.635... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Does failure hurt? The effects of failure feedback on pain report, pain tolerance and pain avoidance. | In this study an experiment was conducted to examine whether failure experiences have an effect on pain report, pain tolerance and pain avoidance. Furthermore, it was investigated if negative affectivity (NA) affected the impact of failure feedback on pain report, either as a mediator, in the case of negative state aff... | ['Adolescent', 'Adult', 'Analysis of Variance', 'Behavior', 'Biofeedback, Psychology', 'Cold Temperature', 'Female', 'Humans', 'Pain Measurement', 'Pain Threshold', 'Predictive Value of Tests', 'Regression Analysis', 'Stress, Psychological'] | 11,124,005 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F01.145'], ['E02.190.525.123', 'F02.830.131', 'F04.754.137.301', 'F04.754.308.500'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Is sublobar resection sufficient for carcinoid tumors? | BACKGROUND: The existing guidelines for extent of resection of carcinoid tumors are based on other, more malignant non-small cell lung cancers. Because of the small number of patients in any single institution, we analyzed the Surveillance Epidemiology and End Results (SEER) database to study the effect of the extent o... | ['Carcinoid Tumor', 'Databases, Factual', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Pneumonectomy', 'Retrospective Studies', 'SEER Program', 'Survival Rate'] | 21,704,299 | [['C04.557.465.625.650.200', 'C04.557.470.200.025.200', 'C04.557.580.625.650.200'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['E04.620', 'E04.928.600.600'], ['E05.318.372.500.500.500',... | ['Diseases [C]', 'Information Science [L]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Collagen XV, a novel factor in zebrafish notochord differentiation and muscle development. | Muscle cells are surrounded by extracellular matrix, the components of which play an important role in signalling mechanisms involved in their development. In mice, loss of collagen XV, a component of basement membranes expressed primarily in skeletal muscles, results in a mild skeletal myopathy. We have determined the... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Basement Membrane', 'Body Patterning', 'Cloning, Molecular', 'Collagen', 'Hedgehog Proteins', 'Molecular Sequence Data', 'Motor Neurons', 'Muscle Development', 'Notochord', 'Signal Transduction', 'Zebrafish', 'Zebrafish Proteins'] | 18,281,032 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A10.272.220', 'A10.615.179'], ['G07.345.500.100'], ['E05.393.220'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D12.644.276.671', 'D12.776.467.671', 'D23.529.671'], ['L01.453.245.667'], ['A08.675.655... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Identifying young people exposed to or at risk of sexual ill health: pilot implementation of an evidence-informed toolkit (SEXIT) at Swedish youth clinics. | OBJECTIVES: We aimed to develop and pilot-implement an evidence-informed toolkit (SEXual health Identification Tool; SEXIT) for identifying young people exposed to or at risk of sexual ill health, at Swedish youth clinics, and to investigate SEXIT's potential to identify young people in need of special care and monitor... | ['Adolescent', 'Adolescent Behavior', 'Family Planning Services', 'Feasibility Studies', 'Female', 'Health Plan Implementation', 'Humans', 'Male', 'Pilot Projects', 'Risk Assessment', 'Risk-Taking', 'Sex Education', 'Sexual Behavior', 'Sexual Health', 'Sexual Partners', 'Sweden', 'Young Adult'] | 30,730,215 | [['M01.060.057'], ['F01.145.022'], ['N02.421.143.401', 'N02.421.800.249'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['N03.349.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['E05.318.740.6... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Open-label trial of atomoxetine hydrochloride in adults with ADHD. | BACKGROUND: While atomoxetine is an established treatment for attention-deficit/hyperactivity disorder in children, few studies have examined its efficacy for adults.METHODS: Open-label trial of atomoxetine in 20 individuals with ADHD, aged 19-47 years, for 10 weeks, and a total of one year for responders.RESULTS: Ten ... | ['Adrenergic Uptake Inhibitors', 'Adult', 'Atomoxetine Hydrochloride', 'Attention Deficit Disorder with Hyperactivity', 'Drug Administration Schedule', 'Female', 'Humans', 'Intention to Treat Analysis', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Patient Selection', 'Propylamines', 'Time', 'Treatment Outcome'] | 19,458,384 | [['D27.505.519.562.437.050', 'D27.505.519.625.050.601', 'D27.505.519.625.600.050', 'D27.505.696.577.050.601', 'D27.505.696.577.600.050'], ['M01.060.116'], ['D02.092.831.085'], ['F03.625.094.150'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.250.250.365.500.500', 'N05.715.360.330.250.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The relationship between differences in regional growth rates and changes in shape during human fetal craniofacial growth. | Large differences in growth rates between various craniofacial regions have been reported but have not distinguished between absolute and relative rates. Measurements on 60 fetuses, 49-212 mm crown-rump length, showed that absolute growth rates correlated highly with size of the craniofacial region measured (r = 0.9996... | ['Cephalometry', 'Embryonic and Fetal Development', 'Face', 'Facial Bones', 'Humans', 'Skull'] | 3,857,883 | [['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['G07.345.500.325', 'G08.686.784.170'], ['A01.456.505'], ['A02.835.232.781.324'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Vulvar surgery for neurofibromatosis. | Von Recklinghausen's neurofibromatosis is an unusual disorder with a wide variety of manifestations. The initial findings may at times involve the female genitalia. When the vulva is affected, the obstetrician-gynecologist has an opportunity for the establishment of an accurate diagnosis as well as for cosmetic correct... | ['Adult', 'Child', 'Female', 'Humans', 'Neurofibromatosis 1', 'Vulvar Neoplasms'] | 3,917,565 | [['M01.060.116'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.580.600.580.590.650', 'C04.700.631.650', 'C10.562.600.500', 'C10.574.500.549.400', 'C10.668.829.675', 'C16.320.400.560.400', 'C16.320.700.633.650'], ['C04.588.945.418.968', 'C13.351.500.944.819', 'C13.351.937.418.968']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A comprehensive ubiquitous healthcare solution on an Android™ mobile device. | Provision of ubiquitous healthcare solutions which provide healthcare services at anytime anywhere has become more favorable nowadays due to the emphasis on healthcare awareness and also the growth of mobile wireless technologies. Following this approach, an Android™ smart phone device is proposed as a mobile monitorin... | ['Cell Phone', 'Delivery of Health Care', 'Electrocardiography, Ambulatory', 'Humans', 'Remote Sensing Technology', 'Telemedicine', 'Wireless Technology'] | 22,163,986 | [['L01.178.847.698.300'], ['N04.590.374', 'N05.300'], ['E01.370.370.380.240.230', 'E01.370.405.240.230', 'E01.370.520.500.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.520.750.500', 'E05.925.500', 'L01.178.847.675.500'], ['H02.403.840', 'L01.178.847.652', 'N04.590.374.800'], ['L01.178.847.950']] | ['Information Science [L]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
[Results of a questionnaire issued to expectant and delivered mothers (author's transl)]. | At the Department of Obstetrics and Gynaecology, Wilhelminenspital der Stadt Wien, Vienna, 98% of all deliveries are continuously monitored. 30% (1979) received epidural anaesthesia. The presence of the husband in the delivery room and partial rooming-in is available to all mothers. To find out if the service to expect... | ['Anesthesia, Epidural', 'Austria', 'Consumer Behavior', 'Female', 'Fetal Monitoring', 'Hospital Departments', 'Humans', 'Infant, Newborn', 'Labor, Obstetric', 'Obstetrics and Gynecology Department, Hospital', 'Pregnancy', 'Rooming-in Care'] | 7,281,696 | [['E03.155.086.131'], ['Z01.542.088'], ['F01.145.236'], ['E01.370.378.230', 'E01.370.520.230'], ['N02.278.216.500.968', 'N04.452.442.452.422'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['G08.686.784.769.326'], ['N02.278.216.500.968.495', 'N04.452.442.452.422.495'], ['G08.686.784.769'], ['N0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Treating chronically ill people with diabetes mellitus with limited life expectancy: implications for performance measurement. | OBJECTIVES: To develop an algorithm to identify individuals with limited life expectancy and examine the effect of limited life expectancy on glycemic control and treatment intensification in individuals with diabetes mellitus.DESIGN: Individuals with diabetes mellitus and coexisting congestive heart failure, chronic o... | ['Aged', 'Algorithms', 'Chronic Disease', 'Diabetes Mellitus', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Life Expectancy', 'Male', 'Middle Aged', 'Treatment Outcome'] | 22,260,627 | [['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['C23.550.291.500'], ['C18.452.394.750', 'C19.246'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381', 'D12.776.422.316.762.380.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.450', 'N01.224.935.464', 'N06.850.505.400.975.450', ... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Freeze-all, oocyte vitrification, or fresh embryo transfer? Lessons from an egg-sharing donation program. | OBJECTIVE: To compare the outcomes of ETs using cryopreserved embryos, cryopreserved oocytes, or fresh embryos.DESIGN: Observational, cohort study.SETTING: Private university-affiliated fertility center.PATIENT(S): This study included 8,210 mature oocytes obtained from 425 oocyte donors. Of those, 5,440 were used for t... | ['Adult', 'Blastocyst', 'Cryopreservation', 'Embryo Implantation', 'Embryo Transfer', 'Female', 'Fertility', 'Humans', 'Infertility', 'Middle Aged', 'Oocyte Donation', 'Pregnancy', 'Pregnancy Rate', 'Program Evaluation', 'Risk Factors', 'Sperm Injections, Intracytoplasmic', 'Tissue Preservation', 'Treatment Outcome', '... | 27,262,501 | [['M01.060.116'], ['A16.254.500'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['G08.686.784.170.104.500'], ['E02.875.800.500', 'E05.820.800.500'], ['G08.686.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Gluten sensitivity in patients with primary biliary cirrhosis. | OBJECTIVE: Whereas celiac disease and primary biliary cirrhosis have been reported to coexist in the same patient, the frequency of this relationship has not been clarified. Nowadays, the concept of celiac disease has been extended from that of a severe enteropathy to a broader concept of gluten-driven intestinal immun... | ['Adult', 'Aged', 'Female', 'Gliadin', 'Glutens', 'Histocompatibility Testing', 'Humans', 'Immunoglobulin A', 'Immunoglobulin G', 'Intestine, Small', 'Liver Cirrhosis, Biliary', 'Male', 'Middle Aged', 'Rectum'] | 9,580,141 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.765.433.500.500.400', 'D12.776.765.725.500.500.400'], ['D12.776.765.433.500.500', 'D12.776.765.725.500.500'], ['E01.370.225.812.385', 'E05.200.812.385', 'E05.478.594.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.026', 'D12.776.124.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Stereochemical specificity for sterols in Saccharomyces cerevisiae. | When sterol biosynthesis in oxygen-deprived wild type Saccharomyces cerevisiae was prevented by the presence of 2,3-iminosqualene, an inhibitor of 2,3-oxidosqualene cyclase, an absolute requirement for a sterol with a 24 beta-methyl group was found. Neither the configuration nor the size of the alkyl group at C-24 coul... | ['Cholesterol', 'Kinetics', 'Saccharomyces cerevisiae', 'Squalene', 'Sterols'] | 6,339,498 | [['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['G01.374.661', 'G02.111.490'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D02.455.326.271.665.806', 'D02.455.849.919.681'], ['D04.210.500.247.808', 'D10.570.938']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Renin and aldosterone]. | The radioimmunological dosages of renin and of aldosterone are used nowadays in clinical practice for research purposes only. The measurement of activity of plasma renin may be considered a significant indication of the concentration of the enzime in plasma and, indirectly, of its secretion. Several factors take a par... | ['Aldosterone', 'Angiotensin II', 'Humans', 'Hyperaldosteronism', 'Hypertension', 'Juxtaglomerular Apparatus', 'Liver Cirrhosis', 'Radioimmunoassay', 'Renin'] | 1,232,875 | [['D04.210.500.745.745.654.062', 'D06.472.040.585.353.118'], ['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.053.800.604'], ['C14.907.489'], ['A05.810.453.324.359.520', ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of hypofractionated radiotherapy in the management of head and neck cancer - a modelling approach. | INTRODUCTION: Cancer stem cells (CSCs) and hypoxia are key contributors towards radioresistance and they influence the choice of radiotherapy schedule for optimal tumour control. Since hypofractionation is becoming more popular in head and neck cancer (HNC) management, the aim of this work is to use a modelling approac... | ['Cell Proliferation', 'Computer Simulation', 'Head and Neck Neoplasms', 'Humans', 'Models, Biological', 'Monte Carlo Method', 'Neoplasm Recurrence, Local', 'Neoplastic Stem Cells', 'Radiation Dose Hypofractionation', 'Radiation Tolerance', 'Squamous Cell Carcinoma of Head and Neck', 'Tumor Burden', 'Tumor Cells, Cultu... | 31,493,484 | [['G04.161.750', 'G07.345.249.410.750'], ['L01.224.160'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['C04.697.655', 'C23.550.727.655'], ['A11.872.650'], ['E02.815.639.200.500'], ['G04.712', 'G0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Reflex regulation of hormonal responses during pregnancy. | 1. During pregnancy in most species, the resting levels of plasma angiotensin II, plasma ACTH (corticotropin) are increased. The concentration of vasopressin is also increased relatively to the osmolality in rats and in humans. 2. In the pregnant state mean arterial pressure is decreased, despite an increase in blood v... | ['Adrenocorticotropic Hormone', 'Animals', 'Arginine Vasopressin', 'Blood Pressure', 'Estrogens', 'Female', 'Glucose', 'Nitroprusside', 'Pregnancy', 'Pregnancy, Animal', 'Renin', 'Time Factors'] | 7,621,608 | [['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. | The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We hypothesise that early life physical and psychosocial environments, immunological, physiological, nutritional, hormonal and metabolic influences interact with gene... | ['Adult', 'Asthma', 'Canada', 'Child', 'Child Development', 'Child, Preschool', 'Chronic Disease', 'Cohort Studies', 'Female', 'Gene-Environment Interaction', 'Humans', 'Hypersensitivity', 'Infant', 'Longitudinal Studies', 'Male', 'Pregnancy', 'Socioeconomic Factors', 'Surveys and Questionnaires'] | 26,069,286 | [['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['Z01.107.567.176'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['M01.060.406.448'], ['C23.550.291.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G05.695.337'], ['B01.050.150.90... | ['Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Silicon-based optical leaky wave antenna with narrow beam radiation. | We propose a design of a dielectric (silicon nitride) optical leaky wave antenna (OLWA) with periodic semiconductor (silicon) corrugations, capable of producing narrow beam radiation. The optical antenna radiates a narrow beam because a leaky wave (LW) with low attenuation constant is excited at one end of the corrugat... | ['Computer-Aided Design', 'Equipment Design', 'Equipment Failure Analysis', 'Light', 'Photometry', 'Silicon', 'Transducers'] | 21,643,126 | [['L01.224.108.150', 'L01.296.110.150'], ['E05.320'], ['E05.325.192'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.196.712'], ['D01.268.513.937'], ['E07.305.812']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Acute and chronic effects of adriamycin on fatty acid oxidation in isolated cardiac myocytes. | This study was designed to determine if acute (in vitro) or chronic (in vivo) adriamycin inhibits cardiac fatty acid oxidation and if so at what sites in the fatty acid oxidation pathway. In addition, the role of L-carnitine in reversing or preventing this effect was examined. We determined the effects of adriamycin in... | ['Animals', 'Antibiotics, Antineoplastic', 'Caprylates', 'Carnitine', 'Carnitine O-Palmitoyltransferase', 'Cells, Cultured', 'Dose-Response Relationship, Drug', 'Doxorubicin', 'Fatty Acids', 'Glucose', 'Heart', 'Male', 'Mitochondria, Heart', 'Myocardium', 'Oxidation-Reduction', 'Palmitic Acid', 'Pyruvic Acid', 'Rats', ... | 9,140,835 | [['B01.050'], ['D27.505.954.248.106'], ['D02.241.081.222', 'D10.251.122'], ['D02.092.877.883.099'], ['D08.811.913.050.350.200'], ['A11.251'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['D10.251'], ['D09.947.875.359.448'], ['A07... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of training and albuterol on pain and fatigue in facioscapulohumeral muscular dystrophy. | BACKGROUND: We recently reported a randomised controlled trial on the efficacy of strength training and the beta2-adrenergic agonist albuterol in patients with facioscapulohumeral muscular dystrophy (FSHD). Strength training and albuterol appeared safe interventions with limited positive effect on muscle strength and v... | ['Adrenergic beta-Agonists', 'Adult', 'Albuterol', 'Combined Modality Therapy', 'Double-Blind Method', 'Exercise', 'Fatigue', 'Female', 'Humans', 'Male', 'Middle Aged', 'Muscle Strength', 'Muscular Dystrophy, Facioscapulohumeral', 'Pain', 'Pain Management', 'Pain Measurement', 'Physical Fitness', 'Sickness Impact Profi... | 17,361,345 | [['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['M01.060.116'], ['D02.033.100.291.057', 'D02.092.063.291.057', 'D02.092.471.683.061'], ['E02.186'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['G11.427.410.698.277', 'I03.350'], ['C23.888.369'], ['B01.050.150.9... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Potential Moderating Effects of Psychiatric Diagnosis and Symptom Severity on Subjective and Behavioral Responses to Reduced Nicotine Content Cigarettes. | INTRODUCTION: Given FDA's authority to implement a cigarette nicotine reduction policy, possible outcomes of this regulation must be examined, especially among those who may be most affected, such as those with comorbid psychiatric disorders.METHODS: In this secondary analysis of a multisite, randomized, clinical labor... | ['Anxiety', 'Depression', 'Humans', 'Nicotine', 'Smokers', 'Smoking', 'Smoking Cessation', 'Tobacco Products'] | 31,867,653 | [['F01.470.132'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.132.760.570', 'D03.383.725.518'], ['M01.808'], ['F01.145.805'], ['F01.145.488.732'], ['J01.637.767.844']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Hyperhomocysteinaemia: risk of retinal vascular occlusion. | To investigate the possible relationship between hyperhomocysteinaemia and retinal vascular occlusion, we measured plasma homocysteine levels in 25 patients with a history of retinal vascular occlusion in the previous 2 years and in a control group of 24. The difference in mean plasma homocysteine levels was not statis... | ['Adult', 'Age of Onset', 'Aged', 'Aged, 80 and over', 'Case-Control Studies', 'Diabetes Complications', 'Female', 'Homocysteine', 'Hospitals, Teaching', 'Humans', 'Hyperhomocysteinemia', 'Hyperlipidemias', 'Hypertension', 'Iran', 'Male', 'Middle Aged', 'Retinal Vein Occlusion', 'Risk Factors', 'Sample Size', 'Single-B... | 16,335,656 | [['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C19.246.099'], ['D02.886.030.498', 'D12.125.166.498'], ['N02.278.020.300', 'N02.278.421.639'], ['B01.050.150.900.649.313.988.40... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Response compatibility and the relationship between event-related potentials and the timing of a motor response. | 1. Earlier studies have shown that changes in the difficulty of sensory discrimination in a choice reaction time task result in a prolongation of the peak latency for several components of the long-latency event-related potential (ERP). With the use of the technique of response-locked averaging, we have previously show... | ['Adult', 'Discrimination Learning', 'Electroencephalography', 'Electromyography', 'Evoked Potentials, Motor', 'Female', 'Humans', 'Male', 'Middle Aged', 'Motor Activity', 'Photic Stimulation', 'Psychomotor Performance', 'Reaction Time', 'Reference Values'] | 8,985,868 | [['M01.060.116'], ['F02.463.425.280'], ['E01.370.376.300', 'E01.370.405.245'], ['E01.370.405.255', 'E01.370.530.255'], ['G07.265.216.500.385', 'G11.561.200.500.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.145.632', 'G11.427.410.698'], ['E05.723.729'], ['F02.808', 'G11.427.700', 'G1... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Antagonists of ionotropic gamma-aminobutyric acid receptors impair the NiCl2-mediated stimulation of the electroretinogram b-wave amplitude from the isolated superfused vertebrate retina. | PURPOSE: NiCl(2) (15 microM) stimulates the electroretinogram (ERG) b-wave amplitude of vertebrate retina up to 1.5-fold through its blocking of E/R-type voltage-gated Ca(2+) channels. Assuming that such an increase is mediated by blocking the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) vi... | ['Animals', 'Bicuculline', 'Calcium Channels', 'Calcium Channels, R-Type', 'Cation Transport Proteins', 'Cattle', 'Dose-Response Relationship, Drug', 'Drug Combinations', 'Electroretinography', 'GABA Antagonists', 'Glycine Agents', 'In Vitro Techniques', 'Nickel', 'Night Vision', 'Phosphinic Acids', 'Photoreceptor Cell... | 20,002,018 | [['B01.050'], ['D03.132.098.077', 'D03.633.100.531.085.077'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['D12.776.157.530.400.150.585.867', 'D12.776.543.550.450.150.585.867', 'D12.776.543.585.400.150.585.867'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'], ['B01.050.15... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clonal proliferation and cytokine requirement of murine progenitors for natural killer cells. | We have established a clonal cell culture system that supports the proliferation of committed natural killer (NK) cell progenitors of mice to investigate the pathway and cytokine regulation of NK cell development. Day 14 fetal thymocytes cultured in methylcellulose with interleukin-7 (IL-7), IL-15, and steel factor (SF... | ['Animals', 'Cell Culture Techniques', 'Cell Division', 'Clone Cells', 'Cytokines', 'Dose-Response Relationship, Drug', 'Hematopoietic Stem Cells', 'Killer Cells, Natural', 'Mice'] | 9,166,839 | [['B01.050'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.353'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.148.378', 'A11.872.378', 'A15.378.31... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Malakoplakia of the ureter and bladder. | Malakoplakia is an uncommon granulomatous inflammatory disease that most often involves the urinary tract. Typically, there is an associated urinary tract infection (UTI) by coliform organisms. Histologically, the Michaelis-Gutmann bodies are the hallmark of this disease. Radiographically, malakoplakia may simulate oth... | ['Aged', 'Aged, 80 and over', 'Diagnosis, Differential', 'Female', 'Humans', 'Malacoplakia', 'Male', 'Middle Aged', 'Radiography', 'Ureteral Diseases', 'Urinary Bladder Diseases'] | 2,281,580 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.548'], ['M01.060.116.630'], ['E01.370.350.700'], ['C12.777.725', 'C13.351.968.725'], ['C12.777.829', 'C13.351.968.829']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Vasoactive intestinal polypeptide and somatostatin in experimental endogenous gram-negative peritonitis. | Vasoactive intestinal polypeptide (VIP) and somatostatin were measured during endogenous gram-negative peritonitis and septicaemia in rats. Both peptides were found to increase in blood, but not in peritoneal fluid. The VIP values coincided with the levels of endotoxin and bacterial counts. However, if the development ... | ['Animals', 'Endotoxins', 'Gram-Negative Bacteria', 'Male', 'Models, Biological', 'Peritoneum', 'Peritonitis', 'Rats', 'Rats, Inbred Strains', 'Sepsis', 'Somatostatin', 'Vasoactive Intestinal Peptide'] | 2,869,631 | [['B01.050'], ['D23.946.123.329'], ['B03.440'], ['E05.599.395'], ['A01.923.047.025.600', 'A10.615.789.596'], ['C01.463.600', 'C06.844.640'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['C01.757', 'C23.550.470.790.500'], ['D06.472.699.327.700.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Emotional intelligence competencies provide a developmental curriculum for medical training. | Since healthcare faces challenges of access, quality, and cost, effective leadership for healthcare is needed. This need is especially acute among physicians, whose demanding training focuses on scientific and clinical skills, eclipsing attention to leadership development. Among the competencies needed by leaders, emot... | ['Curriculum', 'Education, Medical, Undergraduate', 'Emotional Intelligence', 'Humans', 'Leadership', 'Students, Medical', 'United States'] | 23,360,483 | [['I02.158'], ['I02.358.399.450'], ['F01.752.543.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.609'], ['M01.848.769.602'], ['Z01.107.567.875']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
Applicability of MIKE 21 to assess temporal and spatial variation in water quality of an estuary under the impact of effluent from an industrial estate. | This study aims at analysing the impact of wastewater load of industrial units in Haldia on the water quality of the Hoogly estuary using numerical modelling techniques. Modelling was never attempted in this region because it was generally felt that simulating such a complex system would not be easy with limited data a... | ['Environmental Monitoring', 'India', 'Industrial Waste', 'Models, Theoretical', 'Reproducibility of Results', 'Time Factors', 'Waste Disposal, Fluid', 'Water', 'Water Pollutants, Chemical'] | 21,902,033 | [['N06.850.460.350.080', 'N06.850.780.375'], ['Z01.252.245.393'], ['D20.944.420', 'N06.850.460.710.420'], ['E05.599'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['G01.910.857'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['D01.045.250.875', 'D01.248.497.158.4... | ['Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Vascular associated gene variants in patients with preeclampsia: results from the Danish National Birth Cohort. | OBJECTIVE: Preeclampsia has been linked to subsequent vascular disease with many shared predisposing factors. We investigated the association between severe preeclampsia, and its subtypes, and specific vascular-related polymorphisms.DESIGN: The study was a retrospective nested case-cohort design.SETTING: Pregnant Danis... | ['Adult', 'Age Distribution', 'Birth Weight', 'Body Mass Index', 'Case-Control Studies', 'Cohort Studies', 'Denmark', 'Female', 'Genotype', 'Humans', 'Infant, Newborn', 'Infant, Small for Gestational Age', 'Odds Ratio', 'Parity', 'Polymorphism, Single Nucleotide', 'Pre-Eclampsia', 'Pregnancy', 'Pregnancy Outcome', 'Ret... | 22,676,277 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.50... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
MR imaging of meniscal tears: narrow versus conventional window width photography. | Narrow window width photography of magnetic resonance (MR) images of knee menisci is promoted as a useful tool in the detection of meniscal tears. To assess the diagnostic efficacy of this method, conventional and narrow window width MR images of 48 patients (96 menisci, 37 tears) were interpreted by two experienced ob... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Female', 'Humans', 'Knee Injuries', 'Magnetic Resonance Imaging', 'Male', 'Menisci, Tibial', 'Middle Aged', 'ROC Curve', 'Tibial Meniscus Injuries'] | 8,497,639 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.558.554'], ['E01.370.350.825.500'], ['A02.165.308.538.500', 'A02.835.583.475.590', 'A10.165.382.350.163.500'], ['M01.060.116.630'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Unexpectedly high prevalence of sarcoidosis in a representative U.S. Metropolitan population. | The prevalence of sarcoidosis in the United States is unknown, with estimates ranging widely from 1 to 40 per 100,000. We sought to determine the prevalence of sarcoidosis in our health system compared to other rare lung diseases and to further establish if the prevalence was changing over time. We interrogated the ele... | ['Adult', 'African Americans', 'Age Distribution', 'European Continental Ancestry Group', 'Female', 'Humans', 'Lung Diseases', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Ohio', 'Prevalence', 'Rare Diseases', 'Sarcoidosis, Pulmonary', 'Sex Distribution', 'United States'] | 22,417,737 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.686.508.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['Z01.107.567.875.075.512', 'Z01.107.567.875... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction. | cAMP is important in sea urchin sperm signaling, yet the molecular nature of the adenylyl cyclases (ACs) involved remained unknown. These cells were recently shown to contain an ortholog of the mammalian soluble adenylyl cyclase (sAC). Here, we show that sAC is present in the sperm head and as in mammals is stimulated ... | ['Acrosome', 'Acrosome Reaction', 'Adenylyl Cyclases', 'Animals', 'Bicarbonates', 'Dose-Response Relationship, Drug', 'Male', 'Sea Urchins', 'Solubility'] | 17,524,362 | [['A05.360.490.890.820.100', 'A11.284.430.214.190.875.190.550.040', 'A11.497.760.400.100'], ['G08.686.784.277.800.100'], ['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.500.408.578'], ['G02.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Translocation of fluorescent ether phospholipid, but not its diacyl counterpart, after insertion in plasma membranes of control and plasmalogen-deficient fibroblasts. | Fluorescently labelled ether phospholipid (1-O-alkyl/alkenyl-2-acyl- glycerophosphocholine) readily internalizes at low temperatures (2 degrees C) after insertion into the plasma membrane of cultured fibroblasts. This fate differs markedly from that of its diacyl phospholipid analogue, which remains associated with the... | ['Cell Membrane', 'Cells, Cultured', 'Chondrodysplasia Punctata', 'Fibroblasts', 'Humans', 'Membrane Lipids', 'Microscopy, Fluorescence', 'Phosphatidylcholines', 'Phospholipid Ethers', 'Plasmalogens', 'Temperature'] | 8,452,863 | [['A11.284.149'], ['A11.251'], ['C05.116.099.708.195'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.570'], ['E01.370.350.515.458', 'E05.595.458'], ['D10.570.755.375.760.400.800'], ['D02.033.800.875.875.750', 'D02.355.460.750', 'D10.570.755.375.760.400.985'], ['D10.570.755.375.760.400.985.820... | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Therapeutic effects of a synthetic peptide of C-reactive protein in pre-clinical tumor models. | Previous studies have shown that multilamellar vesicles (MLV) or other carriers containing purified human C-reactive protein (CRP) have therapeutic activity in preclinical tumor models. Here we evaluated the therapeutic effects of MLV containing novel synthetic peptides, derived from the structure of CRP, on the extent... | ['Adenocarcinoma', 'Animals', 'C-Reactive Protein', 'Carcinoma, Renal Cell', 'Colonic Neoplasms', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Drug Carriers', 'Fibrosarcoma', 'Humans', 'Immunotherapy', 'Kidney Neoplasms', 'Lung Neoplasms', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', '... | 8,439,977 | [['C04.557.470.200.025'], ['B01.050'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180',... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A randomized, double-blinded trial of preemptive analgesia in laparoscopy. | OBJECTIVE: We tested the hypothesis that local anesthetic administered before skin incision, an example of preemptive analgesia, reduces postoperative pain for women undergoing laparoscopy, as compared with postincisional local anesthetic or placebo.METHODS: Patients undergoing diagnostic laparoscopy were randomized to... | ['Adolescent', 'Adult', 'Analgesia', 'Anesthetics, Local', 'Bupivacaine', 'Double-Blind Method', 'Female', 'Humans', 'Laparoscopy', 'Middle Aged', 'Pain, Postoperative', 'Postoperative Care', 'Preoperative Care'] | 9,840,560 | [['M01.060.057'], ['M01.060.116'], ['E03.091'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['D02.065.199.239', 'D02.092.146.113.239'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program. | Clinical and prognostic significance of preclinical abortions in assisted reproduction is ill defined. Strict diagnostic criteria include a transient and synchronous elevation of serum beta-human chorionic gonadotropin (hCG), estradiol, and progesterone levels 13 days after hCG administration, ending in a bleeding epis... | ['Abortion, Spontaneous', 'Adult', 'Chorionic Gonadotropin', 'Embryo Transfer', 'Estradiol', 'Female', 'Fertilization in Vitro', 'Humans', 'Menstrual Cycle', 'Norway', 'Pregnancy', 'Progesterone', 'Prognosis'] | 2,318,326 | [['C13.703.039', 'G08.686.784.769.496.125'], ['M01.060.116'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['E02.875.800.500', 'E05.820.800.500'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['E02.875.800.750', 'E05.820.800.750'], ['B01.050.150.900.649.313.988.40... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Dichotic listening tests in studying brain-behavior relationships. | The magnitude of perceptual asymmetry (PA) on a CVC fused dichotic words test and on VCV and CV fused nonsense syllables tests were compared. In each test the set of distinguishing phonemic cues was the same; the six English stop consonants, b,p,d,t,g,k. Although test-retest reliability was very high on all three tests... | ['Adult', 'Cues', 'Dichotic Listening Tests', 'Dominance, Cerebral', 'Female', 'Field Dependence-Independence', 'Humans', 'Male', 'Models, Neurological', 'Phonetics', 'Psychoacoustics', 'Speech Perception', 'Wechsler Scales'] | 4,033,907 | [['M01.060.116'], ['F02.463.425.234'], ['E01.370.382.375.200'], ['F02.830.297', 'G11.561.225'], ['F02.463.593.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.642'], ['L01.559.598.518'], ['E01.370.382.375.060.530', 'E01.370.685.628', 'F04.096.753.628'], ['F02.463.593.071.875', 'G07.888.125.875'], [... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Atelectatic tympanic membrane: histologic study. | This study aims to elucidate the morphological difference between the noncollapsible physiologic tympanic membrane (TM) and the collapsible atelectatic TM. Histologic examination of atelectatic TMs obtained at surgery from 16 ears revealed inflammatory changes and destruction of the pars tensa collagenous "backbone." T... | ['Ear Diseases', 'Humans', 'Tympanic Membrane'] | 8,373,096 | [['C09.218'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A09.246.272.702']] | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Socioeconomic factors, health behaviors, and mortality: results from a nationally representative prospective study of US adults. | CONTEXT: A prominent hypothesis regarding social inequalities in mortality is that the elevated risk among the socioeconomically disadvantaged is largely due to the higher prevalence of health risk behaviors among those with lower levels of education and income.OBJECTIVE: To investigate the degree to which 4 behavioral... | ['Adult', 'Aged', 'Alcohol Drinking', 'Body Weight', 'Exercise', 'Female', 'Health Behavior', 'Humans', 'Life Style', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Mortality', 'Proportional Hazards Models', 'Prospective Studies', 'Risk Factors', 'Smoking', 'Socioeconomic Factors', 'United States'] | 9,624,022 | [['M01.060.116'], ['M01.060.116.100'], ['F01.145.317.269'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G11.427.410.698.277', 'I03.350'], ['F01.145.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458'], ['E05.318.372.500.750.50... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. | A variety of analogues of caffeine and theophylline in which the 1-,3-, and 7-methyl substituents have been replaced with n-propyl, allyl, propargyl, and isobutyl and, in a few cases, with chloroethyl, hydroxyethyl, or benzyl were assessed for potency and selectivity as antagonists at A1- and A2-adenosine receptors in ... | ['Animals', 'Caffeine', 'Cell Membrane', 'Cerebral Cortex', 'Indicators and Reagents', 'Mass Spectrometry', 'Rats', 'Receptors, Purinergic', 'Structure-Activity Relationship', 'Theophylline', 'Xanthines'] | 3,806,581 | [['B01.050'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['A11.284.149'], ['A08.186.211.200.885.287.500'], ['D27.720.470.410'], ['E05.196.566'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.543.750.695.700', 'D12.776.543.750.720.700'], ['G02.111.830', 'G07.690.773.997'], ['D03.132.960.751', 'D03.633.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of the opioid receptor antagonist naltrexone on smoking and related behaviors in smokers preparing to quit: a randomized controlled trial. | AIMS: To determine if naltrexone affects smoking behaviors in smokers preparing to quit, and whether or not such pre-quit responses predict post-quit date outcomes.DESIGN: Double-blind, placebo-controlled, randomized study. The current study focused on smoking-related outcomes in the pre-quit phase, which was 1 week pr... | ['Adult', 'Alcohol Drinking', 'Behavior, Addictive', 'Chicago', 'Double-Blind Method', 'Female', 'Humans', 'Male', 'Middle Aged', 'Naltrexone', 'Narcotic Antagonists', 'Smoking', 'Smoking Cessation', 'Treatment Outcome'] | 23,714,324 | [['M01.060.116'], ['F01.145.317.269'], ['F01.145.527.100.120'], ['Z01.107.567.875.350.350.200', 'Z01.107.567.875.510.350.200', 'Z01.433.305'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D03.132.577.249.706... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Adult case of an omphalomesenteric cyst resected by laparoscopic-assisted surgery. | This report describes an extremely rare adult case of an omphalomesenteric cyst resected by laparoscopic-assisted surgery. A 29-years-old Japanese man was referred and admitted to Kyushu University Hospital because of an abdominal mass and an elevated serum CEA (carcinoembryonic antigen) level (21.3 ng/mL) in August 20... | ['Adult', 'Cysts', 'Humans', 'Laparoscopy', 'Male', 'Vitelline Duct'] | 16,521,206 | [['M01.060.116'], ['C04.182', 'C23.300.306'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['A16.920']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Linguistic pattern analysis of misspellings of typically developing writers in grades 1-9. | PURPOSE: A mixed-methods approach, evaluating triple word-form theory, was used to describe linguistic patterns of misspellings.METHOD: Spelling errors were taken from narrative and expository writing samples provided by 888 typically developing students in Grades 1-9. Errors were coded by category (phonological, ortho... | ['Adolescent', 'Adolescent Development', 'Age Factors', 'Child', 'Child Development', 'Educational Measurement', 'Educational Status', 'Female', 'Humans', 'Linguistics', 'Male', 'Phonetics', 'Reading', 'Semantics', 'Verbal Behavior', 'Verbal Learning', 'Vocabulary', 'Writing'] | 22,473,834 | [['M01.060.057'], ['F01.525.049', 'G07.345.374.500'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['I02.399'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.559.598'], ['L01.559.598.518'], ['L01.559.423.557'], ['L01.559.598.745'], ['F01.145.209.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Spouse health status, depressed affect, and resilience in mid and late life: a longitudinal study. | This study used longitudinal data to examine the effects of spousal illness on depressive symptoms among middle-aged and older married individuals and the extent to which the adverse effects of illness in a spouse were mitigated by 2 psychological resources, mastery and self-esteem. Using 1,704 married participants who... | ['Adaptation, Psychological', 'Adult', 'Aged', 'Aged, 80 and over', 'Aging', 'Analysis of Variance', 'Depression', 'Female', 'Health Status', 'Human Development', 'Humans', 'Longitudinal Studies', 'Male', 'Marriage', 'Middle Aged', 'Regression Analysis', 'Resilience, Psychological', 'Self Concept', 'Spouses', 'Stress, ... | 24,364,828 | [['F01.058'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F01.145.126.350'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['F01.525', 'G07.345.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Synthesis and antifungal activity of derivatives of 2- and 3-benzofurancarboxylic acids. | We found that amiodarone has potent antifungal activity against a broad range of fungi, potentially defining a new class of antimycotics. Investigations into its molecular mechanisms showed amiodarone mobilized intracellular Ca2+, which is thought to be an important antifungal characteristic of its fungicidal activity.... | ['Aequorin', 'Amiodarone', 'Antifungal Agents', 'Aspergillus fumigatus', 'Benzofurans', 'Calcium', 'Cryptococcus neoformans', 'Cytoplasm', 'Drug Design', 'Drug Synergism', 'Fungi', 'Humans', 'Indicators and Reagents', 'K562 Cells', 'Magnetic Resonance Spectroscopy', 'Microbial Sensitivity Tests', 'Saccharomyces cerevis... | 22,892,340 | [['D12.776.532.020'], ['D03.633.100.127.075'], ['D27.505.954.122.136'], ['B01.300.381.081.295'], ['D03.633.100.127'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['B01.300.381.258.366', 'B01.300.930.316.366'], ['A11.284.430.214'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['G07.690.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Lack of efficacy of topical mycophenolic acid in psoriasis vulgaris. | Mycophenolic acid is effective for systemic treatment of psoriasis. However, there is no report about its topical use in this cutaneous disorder so far. We undertook a randomized, placebo-controlled, within subject comparison of mycophenolic acid 1% incorporated in an ointment base and the corresponding vehicle alone (... | ['Adult', 'Aged', 'Double-Blind Method', 'Humans', 'Immunosuppressive Agents', 'Male', 'Middle Aged', 'Mycophenolic Acid', 'Psoriasis'] | 10,775,867 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['M01.060.116.630'], ['D02.241.081.193.678', 'D10.251.618'], ['C17.800.859.675']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of sex on the diagnostic efficacy of dobutamine stress echocardiography with early atropine administration in the detection of coronary artery disease. | INTRODUCTION: Considering a poorer diagnostic accuracy of exercise stress test in women, echocardiographic stress tests are often recommended for the diagnosis of coronary artery disease (CAD) in this patient group.OBJECTIVES: The aim of the study was to compare the diagnostic value of a modified protocol of dobutamine... | ['Atropine', 'Cardiotonic Agents', 'Coronary Angiography', 'Coronary Artery Disease', 'Dobutamine', 'Echocardiography', 'Echocardiography, Stress', 'Electrocardiography', 'Exercise Test', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Sensitivity and Specificity', 'Sex Factors'] | 24,556,795 | [['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['D27.505.954.411.222', 'D27.720.799.080'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250.260', 'C14.907.137.126... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Intense exercise stimulates albumin synthesis in the upright posture. | We tested the hypothesis that an elevation in albumin synthetic rate contributes to increased plasma albumin content during exercise-induced hypervolemia. Albumin synthetic rate was measured in seven healthy subjects at 1-5 and 21-22 h after 72 min of intense (85% peak oxygen consumption rate) intermittent exercise and... | ['Adult', 'Deuterium', 'Exercise', 'Female', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Kinetics', 'Male', 'Oxygen Consumption', 'Phenylalanine', 'Plasma Volume', 'Posture', 'Serum Albumin', 'Supine Position'] | 10,642,360 | [['M01.060.116'], ['D01.268.406.500', 'D01.362.340.500', 'D01.496.289'], ['G11.427.410.698.277', 'I03.350'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['G03.680'], ['D12.125.072.050.685', 'D12.125.142.666'], ['G09.188.130.610', 'G09.330.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Changes in the content of the fibrillar collagens and the expression of their mRNAs in the menisci of the rabbit knee joint during development and ageing. | The menisci are first seen as triangular aggregations of cells in the 20-day rabbit fetus. At 25-days, a matrix that contains types I, III and V collagens has formed. These collagens are also found in the 1-week neonatal meniscus, but by 3 weeks, type II collagen is present in some regions. By 12 to 14 weeks, typically... | ['Aging', 'Animals', 'Collagen', 'Enzyme-Linked Immunosorbent Assay', 'In Situ Hybridization', 'Joint Capsule', 'Joints', 'RNA, Messenger', 'Rabbits'] | 8,762,058 | [['G07.345.124'], ['B01.050'], ['D05.750.078.280', 'D12.776.860.300.250'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.66... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of glucagon or 5-(tetradecyloxy)-2-furoic acid on binding to mitochondria and phosphorylation of ATP-citrate lyase. | To study the binding to mitochondria and the phosphorylation of ATP-citrate lyase (EC 4.1.3.8), isolated rat hepatocytes were fractionated by exposure to digitonin. After incubation of hepatocytes with the hypolipidemic agent 5-(tetradecyloxy)-2-furoic acid, which decreases the cellular CoA, the amount of bound ATP-cit... | ['ATP Citrate (pro-S)-Lyase', 'Animals', 'Cells, Cultured', 'Coenzyme A', 'Furans', 'Glucagon', 'Male', 'Mitochondria, Liver', 'Phosphorylation', 'Rats'] | 7,066,484 | [['D08.811.913.050.331'], ['B01.050'], ['A11.251'], ['D03.633.100.759.646.138.382', 'D08.211.211', 'D13.695.667.138.382', 'D13.695.827.068.382'], ['D03.383.312'], ['D06.472.699.587.730.500', 'D12.644.548.586.730.500'], ['A11.284.430.214.190.875.564.461', 'A11.284.835.626.461'], ['G02.111.665', 'G02.607.780', 'G03.796']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Suicide substrates reveal properties of the homology-dependent steps during integrative recombination of bacteriophage lambda. | BACKGROUND: A fundamental feature of bacteriophage lambda site-specific recombination is the strict requirement for a region of sequence identity between recombining DNA duplexes. It has been difficult to understand how the recombination machinery identifies and responds to nonhomologies as subtle as a single base-pair... | ['Bacteriophage lambda', 'Base Sequence', 'Binding Sites', 'DNA Nucleotidyltransferases', 'DNA, Viral', 'Integrases', 'Molecular Sequence Data', 'Recombination, Genetic', 'Virus Integration'] | 8,574,589 | [['B04.123.150.800.230', 'B04.123.205.230', 'B04.280.090.800.230'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D08.811.913.696.445.308'], ['D13.444.308.568'], ['D08.811.739.500'], ['L01.453.245.667'], ['G05.728'], ['G05.935', 'G06.920.877']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A zebrafish homologue of the Drosophila neurogenic gene Notch and its pattern of transcription during early embryogenesis. | We describe here the primary structure of a zebrafish homologue of the Drosophila neurogenic gene Notch and its pattern of mRNA accumulation during embryogenesis. The gene produces a 8.5 kb transcript encoding a putative transmembrane protein with a high degree of sequence similarity to members of the Notch family, com... | ['Amino Acid Sequence', 'Animals', 'Brain', 'Cloning, Molecular', 'DNA, Complementary', 'Drosophila', 'Embryonic Development', 'Mesoderm', 'Molecular Sequence Data', 'Nervous System', 'RNA, Messenger', 'Sequence Homology, Amino Acid', 'Time Factors', 'Transcription, Genetic', 'Zebrafish'] | 8,297,791 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A08.186.211'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['A16.504.660'], ['L01.453.245.667'], ['A08'], ['D13... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Epidemic dengue 4 in the Yucat?n, M?xico, 1984. | An outbreak of dengue 4 occurred in the Yucat?n, M?xico in 1984. During the course of the outbreak, 538 of 5486 reported cases of dengue-like illness were studied; 200 were confirmed as dengue serologically and/or virologically. Dengue 4 virus was isolated from 34 patients and dengue 1 from one. Severe haemorrhagic sym... | ['Adolescent', 'Adult', 'Age Distribution', 'Child', 'Dengue', 'Dengue Virus', 'Disease Outbreaks', 'Female', 'Humans', 'Male', 'Mexico', 'Middle Aged', 'Sex Distribution'] | 8,115,814 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.406'], ['C01.920.500.270', 'C01.925.081.270', 'C01.925.782.350.250.214', 'C01.925.782.417.214'], ['B04.820.578.344.350.270'], ['N06.850.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.589'], ['M01.0... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Estimation of optimal feeding strategies for fed-batch bioprocesses. | A generic methodology for feeding strategy optimization is presented. This approach uses a genetic algorithm to search for optimal feeding profiles represented by means of artificial neural networks (ANN). Exemplified on a fed-batch hybridoma cell cultivation, the approach has proven to be able to cope with complex opt... | ['Algorithms', 'Bioreactors', 'Computer Simulation', 'Models, Theoretical'] | 15,928,931 | [['G17.035', 'L01.224.050'], ['E07.115', 'J01.897.120.115'], ['L01.224.160'], ['E05.599']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Accuracy of digital panoramic images displayed on monitor, glossy paper, and film for assessment of mandibular third molars. | OBJECTIVE: The aim of this study was to compare the accuracy of 3 modalities of digital panoramic radiographs-monitor-displayed images and printed copies on glossy paper and on blue transparent film-for assessment of position and morphology of mandibular third molars.STUDY DESIGN: 164 third molars were recorded with on... | ['Adolescent', 'Adult', 'Computer Terminals', 'Data Display', 'Humans', 'Mandible', 'Matched-Pair Analysis', 'Molar, Third', 'Observer Variation', 'Paper', 'Printing', 'Radiography, Dental, Digital', 'Radiography, Panoramic', 'Reproducibility of Results', 'Tooth, Impacted'] | 15,316,548 | [['M01.060.057'], ['M01.060.116'], ['L01.224.230.260.115.500'], ['F02.784.412.221', 'L01.296'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['E05.318.370.485', 'E05.318.740.475', 'N05.715.360.325.500', 'N05.715.360.750.500', 'N06.850.520.445.485', 'N06.850.520.830.47... | ['Named Groups [M]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
Visualization of aortic valve leaflets using black blood MRI. | Although magnetic resonance imaging (MRI) is capable of imaging various physiological parameters associated with the heart valves, it has generally been difficult to visualize the valve leaflets directly. The aortic valve was imaged in 120 patients referred for cardiac MRI to assess myocardial volumes or mass. The aver... | ['Adult', 'Aortic Valve', 'Feasibility Studies', 'Female', 'Heart Valve Diseases', 'Humans', 'Image Enhancement', 'Magnetic Resonance Imaging', 'Male'] | 10,548,787 | [['M01.060.116'], ['A07.541.510.110'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['C14.280.484'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.370.350.825.500']] | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Weekly 5-fluorouracil and leucovorin: achieving lower toxicity with higher dose-intensity in adjuvant chemotherapy after colorectal cancer resection. | BACKGROUND: Current standard therapy following resection of high-risk colon cancer is intravenous bolus 5-fluorouracil (5-FU) with leucovorin (LV), but there is no consensus on the optimum regimen of these drugs: practice ranges from the high toxicity Mayo Clinic schedule to the very low toxicity weekly QUASAR schedule... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Chemotherapy, Adjuvant', 'Colorectal Neoplasms', 'Female', 'Fluorouracil', 'Humans', 'Leucovorin', 'Male', 'Middle Aged', 'Treatment Outcome'] | 15,033,660 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E02.186.170', 'E02.319.170'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['D03.383.742.698.875.404'], ['B01.050.150.900... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Telemedicine support system in home care of patients with chronic respiratory failure: preliminary results]. | We report the preliminary results of an advanced telemedicine system for the delivery of home care services. We have been trying out a system for a ternary telemedicine network for remote consultation in patients with chronic respiratory failure. The elements of this system are: the patients at home, the home doctor (a... | ['Aged', 'Chronic Disease', 'Computer Systems', 'Delivery of Health Care', 'Hemodynamics', 'Home Care Services, Hospital-Based', 'Humans', 'Male', 'Oxygen Inhalation Therapy', 'Quality of Life', 'Respiration', 'Respiratory Insufficiency', 'Telemedicine'] | 12,772,595 | [['M01.060.116.100'], ['C23.550.291.500'], ['L01.224.230'], ['N04.590.374', 'N05.300'], ['G09.330.380'], ['N02.421.143.524.403'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.880.690'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['G09.772.705'], ['C08.618.846'], ['H02.403.840', 'L01.178.847.65... | ['Named Groups [M]', 'Diseases [C]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Mothers' experiences of the time after the diagnosis of an intrauterine death until the induction of the delivery: a qualitative Internet-based study. | AIM: This study aims to describe how mothers spend the period of time between being diagnosed with a dead baby in utero and the induction of the delivery.MATERIAL AND METHODS: Data were collected using a web questionnaire. Five hundred and fifteen women who had experienced a stillbirth after the 22nd week of gestation ... | ['Adaptation, Psychological', 'Adult', 'Female', 'Fetal Death', 'Humans', 'Internet', 'Mothers', 'Pregnancy', 'Qualitative Research', 'Social Support', 'Stillbirth', 'Surveys and Questionnaires'] | 21,793,995 | [['F01.058'], ['M01.060.116'], ['C13.703.223', 'C23.550.260.585'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['G08.686.784.769'], ['H01.770.644.241.850'], ['I01.880.853.500.600'], ['C13.703.223.650', 'C23.550.260.... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Hea... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. | G-protein-coupled receptor kinase 2 (GRK2) is a central regulator of G-protein-coupled receptor signaling. We report that Mdm2, an E3-ubiquitin ligase involved in the control of cell growth and apoptosis, plays a key role in GRK2 degradation. Mdm2 and GRK2 association is enhanced by beta(2)-adrenergic receptor stimulat... | ['Apoptosis', 'Arrestins', 'Cell Line', 'G-Protein-Coupled Receptor Kinase 2', 'Gene Expression Regulation, Enzymologic', 'Humans', 'Insulin-Like Growth Factor I', 'Oncogene Protein v-akt', 'Protein Processing, Post-Translational', 'Proto-Oncogene Proteins c-mdm2', 'Signal Transduction', 'Ubiquitin', 'Ubiquitin-Protein... | 17,006,543 | [['G04.146.954.035'], ['D12.644.360.024.098', 'D12.776.157.057.005', 'D12.776.306.090', 'D12.776.476.024.104', 'D12.776.543.090'], ['A11.251.210'], ['D08.811.913.696.620.682.700.364.049.200', 'D12.644.360.293.249.200', 'D12.776.476.293.249.200'], ['G05.308.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.6... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Accessibility Videos. | It can be difficult to understand accessibility, if you do not have the personal experience. The Accessibility Centre ESKE produced short videos which demonstrate the meaning of accessibility in different situations. Videos will raise accessibility awareness of architects, other planners and professionals in the constr... | ['Architectural Accessibility', 'Disabled Persons', 'Humans', 'Teaching', 'Video Recording'] | 27,534,282 | [['J01.086.339.070'], ['M01.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.903'], ['L01.280.960']] | ['Technology, Industry, and Agriculture [J]', 'Named Groups [M]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 |
Molecular epidemiology of Entamoeba spp.: evidence of a bottleneck (Demographic sweep) and transcontinental spread of diploid parasites. | Entamoeba histolytica causes amebic colitis and liver abscess in developing countries such as Mexico and India. Entamoeba dispar is morphologically identical but is not associated with disease. Here we determined the ploidy of E. histolytica and developed PCR-based methods for distinguishing field isolates of E. histol... | ['Actins', 'Amino Acid Sequence', 'Animals', 'Bacterial Proteins', 'Base Sequence', 'Chitinases', 'Demography', 'Diploidy', 'Entamoeba', 'Entamoeba histolytica', 'Entamoebiasis', 'Humans', 'In Situ Hybridization, Fluorescence', 'India', 'Introns', 'Mexico', 'Molecular Epidemiology', 'Molecular Sequence Data', 'Polymera... | 11,015,408 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.450.207'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['G05.700.264'], ['B01.046.500.100.700.335'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Disciplines and Occupati... | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Photoionization assessment of C3-C5 alkadienes and alkenes in urban air. | Hydrocarbons from samples of traffic-polluted urban air were separated by gas chromatography on an aluminium oxide column and assessed simultaneously by photoionization detection (PID) and flame ionization detection (FID) after effluent splitting. The 10.2 eV photoionization detector selectively detects alkadienes and ... | ['Air Pollutants', 'Alkadienes', 'Alkenes', 'Chromatography, Gas', 'Flame Ionization', 'Ions', 'Photochemistry'] | 1,613,058 | [['D27.888.284.101'], ['D02.455.326.271.665.146'], ['D02.455.326.271'], ['E05.196.181.349'], ['E05.196.181.349.390'], ['D01.248.497'], ['H01.181.529.711']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Handedness in a virtual haptic environment: assessments from kinematic behavior and modeling. | This study evaluated hand asymmetries in performance of a dexterous, controlled task under haptic feedback. Participants punctured a virtual membrane with a pushing or pulling movement, using the left or right hand. For pulling movements, the dominant (right) hand exhibited faster average stopping latency and shorter s... | ['Adult', 'Biomechanical Phenomena', 'Environment', 'Feedback, Physiological', 'Female', 'Functional Laterality', 'Humans', 'Male', 'Movement', 'Psychomotor Performance', 'User-Computer Interface'] | 25,553,342 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['G16.500.275', 'N06.230'], ['G07.410.732'], ['F02.830.297.425', 'G11.561.225.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.568', 'G11.427.410'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['L01.224.900.910']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins. | Mia40 and Erv1 execute a disulfide relay to import the small Tim proteins into the mitochondrial intermembrane space. Here, we have reconstituted the oxidative folding pathway in vitro with Tim13 as a substrate and determined the midpoint potentials of Mia40 and Tim13. Specifically, Mia40 served as a direct oxidant of ... | ['Circular Dichroism', 'Disulfides', 'Electrophoresis, Polyacrylamide Gel', 'Hydrogen Peroxide', 'Mitochondrial Membrane Transport Proteins', 'Mitochondrial Proteins', 'Oxidation-Reduction', 'Oxidoreductases Acting on Sulfur Group Donors', 'Protein Folding', 'Saccharomyces cerevisiae Proteins', 'Signal Transduction', '... | 19,477,928 | [['E05.196.867.151'], ['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['E05.196.401.402', 'E05.301.300.319'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['D12.776.543.585.475', 'D12.776.575.750'], ['D12.776.575'], ['G02.700', 'G03.295.531'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Simplified stratum corneum model membranes for studying the effects of permeation enhancers. | The activity of transdermal permeation enhancers is usually evaluated in vitro on human or animal skin, but skin samples can be hard to source and highly variable. To provide a more consistent basis for evaluating the activity of permeation enhancers, we prepared relatively simple and inexpensive artificial membranes t... | ['Administration, Cutaneous', 'Animals', 'Azepines', 'Ceramides', 'Cholesterol', 'Humans', 'Indomethacin', 'Membrane Lipids', 'Membranes, Artificial', 'Permeability', 'Skin', 'Skin Absorption', 'Stearic Acids', 'Swine', 'Theophylline'] | 29,061,325 | [['E02.319.267.120.060'], ['B01.050'], ['D03.383.066'], ['D02.065.313', 'D09.400.410.420.525.200', 'D10.390.470.675.200', 'D10.570.877.360.612.200'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473.420'], ['D10.570'], ['D25.47... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Percutaneous catheter extraction of a ruptured Port-A-Cath in a small child]. | A male child with protein-losing enteropathy received the completely implanted venous access catheter "Port-A-Cath" (Pharmacia Co.) at the age of 13 months for the regular application of human albumine infusions. After 12 months of impeccable functioning the catheter ruptured. By means of a percutaneous transfemoral an... | ['Catheterization, Central Venous', 'Catheters, Indwelling', 'Equipment Failure', 'Foreign Bodies', 'Heart Ventricles', 'Humans', 'Infant', 'Male', 'Parenteral Nutrition', 'Protein-Losing Enteropathies', 'Vena Cava, Superior'] | 3,116,321 | [['E02.148.167', 'E04.100.814.529.875', 'E04.502.382.875', 'E05.157.313'], ['E07.132.500'], ['E05.325'], ['C26.392'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E02.421.505', 'E02.642.500.505'], ['C06.405.469.818'], ['A07.015.908.949.815']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Educational intervention to improve effectiveness in treatment and control of patients with high cardiovascular risk in low-resource settings in Argentina: study protocol of a cluster randomised controlled trial. | INTRODUCTION: Hypercholesterolaemia is estimated to cause 2.6 million deaths annually and one-third of the cases of ischaemic heart disease. In Argentina, the prevalence of hypercholesterolaemia increased between 2005 and 2013 from 27.9% to 29.8%. Only one out of four subjects with a self-reported diagnosis of coronary... | ['Adult', 'Aged', 'Argentina', 'Cardiovascular Diseases', 'Decision Support Techniques', 'Developing Countries', 'Education, Medical, Continuing', 'Education, Pharmacy', 'Healthy Lifestyle', 'Humans', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Hypercholesterolemia', 'Medication Adherence', 'Middle Aged', 'Mobil... | 28,143,840 | [['M01.060.116'], ['M01.060.116.100'], ['Z01.107.757.077'], ['C14'], ['E05.245', 'L01.313.500.750.190'], ['I01.615.500.300'], ['I02.358.212.350', 'I02.358.399.250'], ['I02.358.525'], ['F01.829.458.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.186.071.202.370', 'D27.505.519.389.370', 'D27.505.954... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Di... | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Characteristics of locomotion, muscle strength, and muscle tissue in regenerating rat skeletal muscles. | Although numerous studies have aimed to elucidate the mechanisms used to repair the structure and function of injured skeletal muscles, it remains unclear how and when movement recovers following damage. We performed a temporal analysis to characterize the changes in movement, muscle function, and muscle structure afte... | ['Animals', 'Biomarkers', 'Biomechanical Phenomena', 'Disease Models, Animal', 'Gait Disorders, Neurologic', 'Isometric Contraction', 'Male', 'Muscle Fibers, Skeletal', 'Muscle Strength', 'Muscle, Skeletal', 'Muscular Atrophy', 'Muscular Diseases', 'Predictive Value of Tests', 'Rats', 'Rats, Wistar', 'Regeneration', 'S... | 20,405,501 | [['B01.050'], ['D23.101'], ['G01.154.090', 'G01.374.089'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C10.597.404', 'C23.888.592.413'], ['G11.427.494.472'], ['A10.690.552.500.500', 'A11.620.249'], ['E01.370.600.425', 'G11.427.560'], ['A02.633.567', 'A10.690.552.500'], ['C10.597.613.612', 'C23.300.070.500', 'C23.8... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes. | Synephrine is a natural compound, frequently added to ephedra-free dietary supplements for weight-loss, due to its effects as a nonspecific adrenergic agonist. Though only p-synephrine has been documented in plants, the presence of m-synephrine has also been reported in weight-loss products. The use of synephrine in di... | ['1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt', 'Acetylcysteine', 'Adrenergic alpha-Agonists', 'Animals', 'Antioxidants', 'Biological Transport', 'Catecholamine Plasma Membrane Transport Proteins', 'Gas Chromatography-Mass Spectrometry', 'Glutathione', 'Male', 'Myocytes, Cardiac', 'Organic Cation Transport P... | 21,140,131 | [['D02.455.426.559.389.097.175', 'D02.455.426.559.389.657.166.210', 'D02.886.645.600.080.050.100.150'], ['D02.886.030.230.259', 'D12.125.166.230.259'], ['D27.505.519.625.050.100.100', 'D27.505.696.577.050.100.100'], ['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G03.143'], ['D12.776.157.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Objective passive-smoking indicators and respiratory morbidity in young children. | Exposure to environmental tobacco smoke is associated with increased respiratory morbidity in young children, but few studies have assessed such exposure objectively by urinary cotinine measurements. 501 children aged 1-5 years, a random 5% sample of children attending an outpatient clinic, were classified as exposed o... | ['Child, Preschool', 'Confounding Factors, Epidemiologic', 'Cotinine', 'Environmental Exposure', 'Greece', 'Humans', 'Infant', 'Logistic Models', 'Odds Ratio', 'Random Allocation', 'Respiratory Tract Diseases', 'Tobacco Smoke Pollution'] | 7,630,249 | [['M01.060.406.448'], ['N05.715.350.240', 'N06.850.490.718'], ['D03.383.773.812.180'], ['N06.850.460.350'], ['Z01.542.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Diverse incidences of individual oligopeptides (dipeptidic to hexapeptidic) in proteins of human, bakers' yeast, and Escherichia coli origin registered in the Swiss-Prot data base. | Oligopeptidic permutations of the 20 amino acid residues give rise to proteins of diverse functions. Our long-term goal is to produce a lexicon of oligopeptides, classifying them into at least five categories: (i) ubiquitous, (ii) function specific, (iii) group specific, (iv) species specific, and (v) nonexistent. To b... | ['Amino Acid Sequence', 'Animals', 'Bacterial Proteins', 'Biological Evolution', 'Databases, Factual', 'Dipeptides', 'Escherichia coli', 'Hominidae', 'Humans', 'Molecular Sequence Data', 'Oligopeptides', 'Peptide Fragments', 'Proteins', 'Saccharomyces cerevisiae', 'Switzerland', 'Viral Proteins'] | 7,708,741 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.097'], ['G05.045', 'G16.075'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['D12.644.456.345'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.988.400.112.400'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Cloning of type 8 capsule genes and analysis of gene clusters for the production of different capsular polysaccharides in Staphylococcus aureus. | Eleven serotypes of capsular polysaccharide from Staphylococcus aureus have been reported. We have previously cloned a cluster of type 1 capsule (cap1) genes responsible for type 1 capsular polysaccharide biosynthesis in S. aureus M. To clone the type 8 capsule (cap8) genes, a plasmid library of type 8 strain Becker wa... | ['Bacterial Capsules', 'Carbohydrate Sequence', 'Cloning, Molecular', 'Gene Deletion', 'Genes, Bacterial', 'Immunoelectrophoresis', 'Molecular Sequence Data', 'Multigene Family', 'Polysaccharides, Bacterial', 'Restriction Mapping', 'Sequence Homology, Nucleic Acid', 'Staphylococcus aureus'] | 8,606,192 | [['A20.186'], ['G02.111.570.160', 'L01.453.245.667.160'], ['E05.393.220'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['E01.370.225.812.735.645.350.350', 'E05.196.401.568', 'E05.200.812.735.645.350.350', 'E05.301.300.568', 'E05.478.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Prevalence of clinical abnormalities in cats found to have nonneoplastic middle ear disease at necropsy: 59 cases (1991-2007). | OBJECTIVE: To determine the prevalence of nonneoplastic middle ear disease among cats undergoing necropsy and the prevalence of clinical abnormalities in cats in which nonneoplastic middle ear disease was identified.DESIGN: Retrospective case series.ANIMALS: 59 cats that underwent necropsy between January 1991 and Augu... | ['Animals', 'Cat Diseases', 'Cats', 'Ear, Middle', 'Female', 'Male', 'Otitis Media', 'Prevalence', 'Retrospective Studies'] | 19,793,014 | [['B01.050'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['A09.246.397'], ['C09.218.705.663'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.7... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Diagnosis of an isolated persistent left side superior vena cava by contrast echocardiography compared with invasive angiographic study. | BACKGROUND: The prevalence of left side superior vena cava (LSVC) is low and usually invasive angiography is necessary to validate its presence. Non-invasive echocardiographic study is important for the diagnosis and definition of associated lesions. The aim of this study is to demonstrate the clinical feasibility and ... | ['Adult', 'Aged', 'Echocardiography', 'Echocardiography, Transesophageal', 'Female', 'Humans', 'Male', 'Middle Aged', 'Radiography', 'Vena Cava, Superior'] | 12,365,649 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E01.370.350.130.750.235', 'E01.370.350.850.220.235', 'E01.370.370.380.220.235'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.700'], ['A07.015.908.949.815']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Structure enhancement diffusion and contour extraction for electron tomography of mitochondria. | The interpretation and measurement of the architectural organization of mitochondria depend heavily upon the availability of good software tools for filtering, segmenting, extracting, measuring, and classifying the features of interest. Images of mitochondria contain many flow-like patterns and they are usually corrupt... | ['Diffusion', 'Electron Microscope Tomography', 'HeLa Cells', 'Humans', 'Image Enhancement', 'Image Processing, Computer-Assisted', 'Mitochondria'] | 19,254,765 | [['G01.202', 'G02.196'], ['E01.370.350.825.249', 'E05.595.402.580.239'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['L01.224.308'], ['A11.284.430.214.190.875.564', 'A11.284.835.626']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Regulatory network controlling extracellular proteins in Erwinia carotovora subsp. carotovora: FlhDC, the master regulator of flagellar genes, activates rsmB regulatory RNA production by affecting gacA and hexA (lrhA) expression. | Erwinia carotovora subsp. carotovora produces an array of extracellular proteins (i.e., exoproteins), including plant cell wall-degrading enzymes and Harpin, an effector responsible for eliciting hypersensitive reaction. Exoprotein genes are coregulated by the quorum-sensing signal, N-acyl homoserine lactone, plant sig... | ['Bacterial Proteins', 'Blotting, Northern', 'Blotting, Western', 'DNA-Binding Proteins', 'Models, Biological', 'Pectobacterium carotovorum', 'RNA-Binding Proteins', 'Repressor Proteins', 'Sigma Factor', 'Transcription Factors'] | 18,441,056 | [['D12.776.097'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D12.776.260'], ['E05.599.395'], ['B03.440.450.425.585.120', 'B03.660.250.150.542.120'], ['D12.776.157.725', 'D12.776.664.962'], ['D12.776.260.70... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Capacitative Ca2+ entry contributes to the Ca2+ influx induced by thyrotropin-releasing hormone (TRH) in GH3 pituitary cells. | Treatment of GH3 cells with either hypothalamic peptide thyrotropin-releasing hormone (TRH), the endomembrane Ca2+-ATPase inhibitor thapsigargin or the Ca2+ ionophore ionomycin mobilized, with different kinetics, essentially all of the Ca2+ pool from the intracellular Ca2+ stores. Any of the above- described treatments... | ['Calcium', 'Calcium Channels', 'Calcium-Transporting ATPases', 'Cell Line', 'Cell Membrane Permeability', 'Cytochrome P-450 Enzyme Inhibitors', 'Dihydropyridines', 'Intracellular Membranes', 'Ionomycin', 'Manganese', 'Pituitary Gland, Anterior', 'Signal Transduction', 'Terpenes', 'Thapsigargin', 'Thyrotropin-Releasing... | 8,594,545 | [['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['D08.811.277.040.025.314.250', 'D12.776.157.530.450.250.500', 'D12.776.157.530.813.250', 'D12.776.543.585.450.250.500', 'D12.776.543.585.813.250'], ['A11.251.210'], ['G03.143.335',... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Detoxification of hazardous dust with marine sediment. | Hazardous electric arc furnace dust containing dioxins/furans and heavy metals is blended with harbor sediment, fired at 950-1100 °C to prepare lightweight aggregates. Dust addition can lower the sintering temperature by about 100 °C, as compared to a typical industrial process. After firing at 950 °C and 1050 °C, more... | ['Dioxins', 'Dust', 'Environmental Pollution', 'Geologic Sediments', 'Hot Temperature', 'Industrial Waste', 'Metals, Heavy', 'Microscopy, Electron, Scanning', 'Taiwan'] | 24,461,694 | [['D02.309.500', 'D03.383.231'], ['D20.633.222'], ['N06.850.460'], ['G01.311.330', 'G16.500.320'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['D20.944.420', 'N06.850.460.710.420'], ['D01.268.556', 'D01.552.544'], ['E01.370.35... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling. | Responses to alpha interferon (IFN-á)-based treatment are dependent on both host and viral factors and vary markedly among patients infected with different hepatitis C virus (HCV) genotypes (GTs). Patients infected with GT3 viruses consistently respond better to IFN treatment than do patients infected with GT1 viruses.... | ['Hepacivirus', 'Host-Pathogen Interactions', 'Humans', 'Interferon Type I', 'Models, Biological', 'Phosphorylation', 'Protein Binding', 'Protein Interaction Domains and Motifs', 'Protein Interaction Mapping', 'STAT1 Transcription Factor', 'Signal Transduction', 'Viral Nonstructural Proteins'] | 22,674,974 | [['B04.450.380', 'B04.820.578.344.475'], ['G06.462', 'G16.527.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890', 'D12.776.467.374.440.890', 'D23.529.374.440.890'], ['E05.599.395'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709.275.750.500']... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Accuracy of portable quantitative capnometers and capnographs under prehospital conditions. | This study was designed to assess the pCO(2) accuracy of portable mainstream (Tidal Wave, Novametrix; Propaq 106, Protocol) and sidestream capnometers (Capnocheck 8200, BCI; Capnocount mini, Weinmann; NPB-75, Nellcor Puritan Bennett; SC-210, Pryon) with respect to international standards and preclinical emergency condi... | ['Capnography', 'Emergency Treatment', 'Equipment Design', 'Humans', 'Statistics, Nonparametric'] | 14,655,228 | [['E01.370.386.700.150'], ['E02.365'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.995', 'N05.715.360.750.760', 'N06.850.520.830.995']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Molecular sequencing and morphological identification reveal similar patterns in native bee communities across public and private grasslands of eastern North Dakota. | Bees play a key role in the functioning of human-modified and natural ecosystems by pollinating agricultural crops and wild plant communities. Global pollinator conservation efforts need large-scale and long-term monitoring to detect changes in species' demographic patterns and shifts in bee community structure. The ob... | ['Animals', 'Bees', 'Biodiversity', 'Conservation of Natural Resources', 'Crops, Agricultural', 'Ecosystem', 'Grassland', 'Humans', 'Pollination', 'Sequence Analysis, DNA'] | 31,971,987 | [['B01.050'], ['B01.050.500.131.617.720.500.500.875.387'], ['G16.500.275.157.049', 'N06.230.124.049'], ['J01.256', 'N06.230.080'], ['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['G16.500.275.157', 'N06.230.124'], ['G16.500.275.157.531', 'N06.230.124.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
MASS: meta-analysis of score statistics for sequencing studies. | SUMMARY: MASS is a command-line program to perform meta-analysis of sequencing studies by combining the score statistics from multiple studies. It implements three types of multivariate tests that encompass all commonly used association tests for rare variants. The input files can be generated from the accompanying sof... | ['Data Interpretation, Statistical', 'Genetic Variation', 'Humans', 'Meta-Analysis as Topic', 'Sequence Analysis, DNA', 'Software'] | 23,698,861 | [['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.500', 'E05.581.500.501', 'N05.715.360.325.515', 'N06.850.520.445.500'], ['E05.393.760.700'], ['L01.224.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
An extreme allele of hooded spotting in the Norway rat. | A new allele (he) of hooded white spotting is described. The typical homozygous phenotype is an almost or completely white rat. The almost white animals have variable coloured spots on the sides of the head, usually around or above the eyes or covering the ears. Superficially, the eyes are dark but careful examination ... | ['Alleles', 'Animals', 'Genotype', 'Hair Color', 'Phenotype', 'Rats'] | 2,599,381 | [['G05.360.340.024.340.030'], ['B01.050'], ['G05.380'], ['G13.500', 'G16.690.490'], ['G05.695'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Depressed suicidal adolescent males have an altered cortisol response to a pharmacological challenge. | Dysregulation of the HPA axis and the dysfunction of the central serotonin (5HT) system are the most replicated biomarkers of depression and suicidal ideation and behavior. However, few studies have examined the two systems simultaneously. In this study, cortisol response was measured in depressed adolescents, followin... | ['Adolescent', 'Depressive Disorder, Major', 'Female', 'Humans', 'Hydrocortisone', 'Hypothalamo-Hypophyseal System', 'Male', 'Piperazines', 'Pituitary-Adrenal System', 'Serotonin Receptor Agonists', 'Sex Characteristics', 'Suicidal Ideation', 'Suicide, Attempted'] | 24,524,706 | [['M01.060.057'], ['F03.600.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['A06.688.357', 'A08.186.211.180.497.352.435', 'A08.186.211.200.317.357.352.435', 'A08.713.357'], ['D03.383.606'], ['A06.300.691'], ['D27.505.519... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Evaluation of deformable registration of patient lung 4DCT with subanatomical region segmentations. | Deformable registration is needed for a variety of tasks in establishing the voxel correspondence between respiratory phases. Most registration algorithms assume or imply that the deformation field is smooth and continuous everywhere. However, the lungs are contained within closed invaginated sacs called pleurae and ar... | ['Algorithms', 'Carcinoma, Non-Small-Cell Lung', 'Humans', 'Imaging, Three-Dimensional', 'Lung Neoplasms', 'Phantoms, Imaging', 'Radiographic Image Enhancement', 'Radiographic Image Interpretation, Computer-Assisted', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Subtraction Technique', 'Tomography, X-R... | 18,383,700 | [['G17.035', 'L01.224.050'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['E07.671'], ['E01.370.350.600.350.700', 'E01.370.350.700.70... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
c-ABL tyrosine kinase modulates p53-dependent p21 induction and ensuing cell fate decision in response to DNA damage. | The c-ABL non-receptor tyrosine kinase and the p53 tumor suppressor protein are pivotal modulators of cellular responses to DNA damage. However, a comprehensive understanding of the role of c-ABL kinase in p53-dependent transcription of p21(CIP1/WAF1) and ensuing cell fate decision is still obscure. Here, we demonstrat... | ['Apoptosis', 'Benzamides', 'Cell Line, Tumor', 'Cyclin-Dependent Kinase Inhibitor p21', 'DNA Damage', 'Doxorubicin', 'G2 Phase Cell Cycle Checkpoints', 'HeLa Cells', 'Humans', 'Imatinib Mesylate', 'Piperazines', 'Proto-Oncogene Proteins c-abl', 'Pyrimidines', 'RNA Interference', 'RNA, Small Interfering', 'Tumor Suppre... | 24,177,958 | [['G04.146.954.035'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.644.360.225.500', 'D12.776.157.687.250', 'D12.776.167.187.500', 'D12.776.476.225.500', 'D12.776.624.776.355.500', 'D12.776.660.720.250'], ['G05.200'], ['D02.455.426.559.847.562.050.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Photoexcitation dynamics of coupled semiconducting carbon nanotube thin films. | Carbon nanotubes are a promising means of capturing photons for use in solar cell devices. We time-resolved the photoexcitation dynamics of coupled, bandgap-selected, semiconducting carbon nanotubes in thin films tailored for photovoltaics. Using transient absorption spectroscopy and anisotropy measurements, we found t... | ['Nanotubes, Carbon', 'Photons', 'Quantum Dots', 'Solar Energy'] | 23,464,618 | [['D01.268.150.250.500', 'J01.637.512.850.500'], ['G01.249.705', 'G01.358.500.505.650.782', 'G01.590.540.782', 'G01.750.250.650.782', 'G01.750.770.578.782'], ['E07.705', 'J01.637.512.600.650'], ['G01.750.897', 'N06.230.132.644.500']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Diurnal variation of urinary markers of nucleic acid oxidation. | AIMS: Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo) are biomarkers of oxidative stress with clinical potential in a variety of diseases. As part of their clinical validation, this study aimed to investigate whether the urinary excretion of 8-oxodG and 8-oxoGuo undergoes... | ["8-Hydroxy-2'-Deoxyguanosine", 'Adult', 'Aged', 'Biomarkers', 'Circadian Rhythm', 'Creatinine', 'Deoxyguanosine', 'Female', 'Guanosine', 'Humans', 'Male', 'Middle Aged', 'Oxidation-Reduction', 'Oxidative Stress', 'Reproducibility of Results'] | 24,628,455 | [['D03.633.100.759.590.454.240.500', 'D13.570.230.360.500', 'D13.570.583.454.240.500'], ['M01.060.116'], ['M01.060.116.100'], ['D23.101'], ['G07.180.562.190'], ['D03.383.129.308.207'], ['D03.633.100.759.590.454.240', 'D13.570.230.360', 'D13.570.583.454.240'], ['D03.633.100.759.590.454', 'D13.570.583.454', 'D13.570.800.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characteristics of the immune response in a patient with Whipple's disease. | A patient with Whipple's disease has been studied to examine the effect of antibiotic therapy on the immune status of the patient, and the specific immune response to a cell wall deficient form of an alpha-haemolytic streptococcus (alpha HS) isolated from this patient. T lymphocyte numbers were reduced, and cutaneous a... | ['Adult', 'Antibodies, Bacterial', 'Autoantibodies', 'Female', 'Humans', 'Immunity', 'Immunity, Cellular', 'Streptococcus', 'Tetracycline', 'Whipple Disease'] | 71,895 | [['M01.060.116'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450'], ['G12.450.050.400'], ['B03.353.750.737.872', 'B03.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Phosphate-dependent glutaminase in enterocyte mitochondria and its regulation by ammonium and other ions. | The effects of ammonium and other ions on phosphate dependent glutaminase (PDG) activity in intact rat enterocyte mitochondria were investigated. Sulphate and bicarbonate activated the enzyme in absence and presence of added phosphate. In presence of 10 mM phosphate, ammonium at concentrations <1 mM inhibited the enzym... | ['Animals', 'Bicarbonates', 'Enterocytes', 'Glutaminase', 'Glutamine', 'In Vitro Techniques', 'Ions', 'Male', 'Mitochondria', 'Phosphates', 'Quaternary Ammonium Compounds', 'Rats', 'Rats, Sprague-Dawley', 'Sulfates'] | 12,768,506 | [['B01.050'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['A03.556.124.369.290', 'A10.615.550.444.290', 'A11.436.290'], ['D08.811.277.087.483'], ['D12.125.068.330', 'D12.125.095.461', 'D12.125.154.424'], ['E05.481'], ['D01.248.497'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['D01.029.260.700.675.374... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Three explanations of marital status differences in suicide rates: social integration, marital status integration, and the culture of suicide. | Our first goal is to link empirical measures of three theoretical explanations of marital status differences to the variation in male and female standardized suicide difference coefficients SSDCs in 12 developed countries, circa 1960. We include predictors of Durkheim's social integration hypothesis, Gibbs and Martin's... | ['Cultural Characteristics', 'Female', 'Global Health', 'Humans', 'Interpersonal Relations', 'Male', 'Marriage', 'Models, Psychological', 'Risk Factors', 'Sex Factors', 'Social Behavior', 'Social Environment', 'Suicide'] | 18,210,894 | [['I01.076.201.450.324', 'I01.880.853.100.329'], ['H02.403.371', 'N01.400.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F01.829.263.315.500.500', 'I01.240.361.500.500', 'I01.880.853.150.423.500.500', 'N01.224.361.500.500', 'N01.824.308.500.500'], ['E05.599.695'], ['E05.318.740.600.800.725',... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Dose-response effects of atropine and HI-6 treatment of organophosphorus poisoning in guinea pigs. | HI-6 (1-2-hydroxyiminomethyl-1-pyridino-3-(4-carbamoyl-1-pyridino -2- oxapropane dichloride) has been evaluated as an oxime alternative to pralidoxime, and toxogonin in the treatment of organophosphorus (OP) poisoning. The dose response effects of atropine (ATR) and HI-6 were investigated to more fully explore the inte... | ['Animals', 'Antidotes', 'Atropine', 'Cholinesterase Inhibitors', 'Cholinesterase Reactivators', 'Diazepam', 'Dose-Response Relationship, Drug', 'Drug Synergism', 'Female', 'Guinea Pigs', 'Lethal Dose 50', 'Male', 'Organophosphate Poisoning', 'Organophosphates', 'Oximes', 'Pyridinium Compounds', 'Soman'] | 7,497,907 | [['B01.050'], ['D27.505.696.706.037', 'D27.720.799.037'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['D27.505.519.405.347', 'D27.505.519.625.120.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Distributed Encoding of Reinforcement in Rat Cortico-Striatal-Limbic Networks. | Decision-making in the mammalian brain typically involves multiple brain structures within the midbrain, thalamus, striatum, limbic system, and cortex. Although task specific contributions of each brain region have been identified, neurons responding to reinforcement have been found throughout these structures. We soug... | ['Animals', 'Cerebral Cortex', 'Choice Behavior', 'Corpus Striatum', 'Limbic System', 'Machine Learning', 'Male', 'Neural Networks, Computer', 'Rats, Long-Evans', 'Reinforcement, Psychology'] | 31,229,632 | [['B01.050'], ['A08.186.211.200.885.287.500'], ['F02.463.785.373.346'], ['A08.186.211.200.885.287.249.487'], ['A08.186.211.180'], ['G17.035.250.500', 'L01.224.050.375.530'], ['G17.485', 'L01.224.050.375.605'], ['B01.050.150.900.649.313.992.635.505.700.500'], ['F02.463.425.770']] | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Stacking for nonaqueous capillary electrophoresis. | Nonaqueous capillary electrophoresis (NACE) is a useful mode in CE for separation and quantification of hydrophobic compounds. However, because of the low conductivity of most of the organic solutions, stacking is not used often in this technique and the sample volume is very limited. As a result of the small sample vo... | ['Electrophoresis, Capillary', 'Humans', 'Organic Chemicals', 'Procainamide', 'Salts', 'Sodium Acetate', 'Solvents', 'Tyramine'] | 12,179,981 | [['E05.196.401.190', 'E05.301.300.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02'], ['D02.065.277.650', 'D02.241.223.100.050.500.875', 'D02.241.223.100.100.650', 'D02.455.426.559.389.127.020.937.875', 'D02.455.426.559.389.127.085.650'], ['D01.786'], ['D02.241.081.018.165.500'], ['D27.720.844'], ['D02.092... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Does family experience influence political beliefs? Relation between interparental conflict perceptions and political efficacy in late adolescence. | The study examined the relation between adolescents' interparental conflict perceptions and their political efficacy regarding local issues. Longitudinal data (age 15 and 17) from 444 adolescents were analyzed using structural equation modeling. Results showed that young people experiencing frequent interparental confl... | ['Adolescent', 'Conflict, Psychological', 'Europe', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Intention', 'Longitudinal Studies', 'Male', 'Parent-Child Relations', 'Politics', 'Surveys and Questionnaires', 'Trust'] | 22,024,338 | [['M01.060.057'], ['F01.658.209'], ['Z01.542'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658.650', 'F02.463.306'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['F01.829.263.370.290'], ['I01.738'], ['E05.318.308.980', 'N... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Expression of CD56 and CD19 in Patients with Newly Diagnosed Multiple Myeloma and Their Relationship with Karyotypes and Prognosis]. | OBJECTIVE: To study the relationship between surface markers of CD56 and CD19 and karyotypes and prognosis in multiple myeloma.METHODS: A total of 126 cases of newly diagnosed multiple myeloma in the first hospital of Peking university from 2011 to 2015 were enrolled in this study. Cytogenetic abnormalities and immunop... | ['Chromosome Aberrations', 'Chromosome Deletion', 'Flow Cytometry', 'Humans', 'Immunophenotyping', 'In Situ Hybridization, Fluorescence', 'Karyotyping', 'Multiple Myeloma', 'Prognosis'] | 27,531,777 | [['C23.550.210', 'G05.365.590.175'], ['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G05.558.800.180', 'G05.700.131.500.500'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350',... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of regulation of high blood pressure on plasma endothelin-1 levels in blacks with hypertension. | Plasma concentrations of immunoreactive endothelin-1 (irET-1) are significantly elevated in blacks with hypertension. In the present study, we investigated the effect of the regulation of high blood pressure on plasma irET-1 levels in black hypertensive individuals. After the initial blood samples were collected from 2... | ['Adult', 'African Continental Ancestry Group', 'Aged', 'Endothelin-1', 'Female', 'Humans', 'Hypertension', 'Male', 'Middle Aged'] | 9,832,184 | [['M01.060.116'], ['M01.686.508.100'], ['M01.060.116.100'], ['D12.644.276.400.225', 'D12.776.467.400.225', 'D23.529.400.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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