Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Simultaneous gene clustering and subset selection for sample classification via MDL. | MOTIVATION: The microarray technology allows for the simultaneous monitoring of thousands of genes for each sample. The high-dimensional gene expression data can be used to study similarities of gene expression profiles across different samples to form a gene clustering. The clusters may be indicative of genetic pathwa... | ['Algorithms', 'Cell Line, Tumor', 'Cluster Analysis', 'Colonic Neoplasms', 'Databases, Genetic', 'Gene Expression Profiling', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Leukemia', 'Models, Genetic', 'Models, Statistical', 'Neoplasms', 'Oligonucleotide Array Sequence Analysis', 'Pattern Recognition, Automated... | 12,801,870 | [['G17.035', 'L01.224.050'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['L01.313.500.750.300.188.400.325', 'L01.47... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Study on the efficacy and safety of adefovir dipivoxil treatment in post-liver transplant patients with hepatitis B virus infection and lamivudine-resistant hepatitis B virus. | Hepatitis B virus (HBV) recurrence and de novo HBV infection are frequent events in liver transplantation recipients. Treatment with lamivudine is initially efficient in both infections but the incidence of lamivudine-resistant HBV emergence increases over time. Adefovir appears to be promising in post-liver transplant... | ['Adenine', 'Alanine Transaminase', 'Drug Resistance, Viral', 'Female', 'Hepatitis B', 'Hepatitis B Surface Antigens', 'Hepatitis B e Antigens', 'Hepatitis B virus', 'Hepatitis C', 'Humans', 'Lamivudine', 'Liver Transplantation', 'Male', 'Organophosphonates', 'Recurrence', 'Retrospective Studies', 'Safety'] | 16,386,596 | [['D03.633.100.759.138'], ['D08.811.913.477.700.100'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D23.050.327.495.500.475'], ['D23.050.327.495.500.469'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['C01.221.250.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Introducing early medical abortion in Australia: there is a need to update abortion laws. | Recent changes to Federal Therapeutic Goods Administration legislation have seen the limited introduction of the drug mifepristone to Australia for the purpose of early medical abortion. At the same time it has become evident that both methotrexate and misoprostol, licenced and available for other indications, are bein... | ['Abortifacient Agents, Steroidal', 'Abortion, Legal', 'Australia', 'Family Planning Services', 'Female', 'Government Regulation', 'Humans', 'Legislation as Topic', 'Mifepristone', 'Pregnancy', 'Pregnancy Trimester, First', 'Public Opinion', "Women's Rights"] | 18,082,063 | [['D27.505.696.875.131.200', 'D27.505.954.705.131.200'], ['E04.520.050.055'], ['Z01.639.100', 'Z01.678.100.373'], ['N02.421.143.401', 'N02.421.800.249'], ['I01.880.604.394', 'N03.706.358'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.706.615'], ['D04.210.500.365.415.580'], ['G08.686.784.769'], ['G08.686.707.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind-limb function. | To foster axonal growth from a Schwann cell bridge into the caudal spinal cord, spinal cells caudal to the implant were transduced with adeno-associated viral (AAV) vectors encoding for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (AAV-NT-3). Control rats received AAV vectors encoding for green fluoresce... | ['Adenoviridae', 'Animals', 'Brain Tissue Transplantation', 'Brain-Derived Neurotrophic Factor', 'Female', 'Fluorescent Dyes', 'Gene Transfer Techniques', 'Genetic Vectors', 'Graft Survival', 'Growth Cones', 'Hindlimb', 'Nerve Growth Factors', 'Nerve Regeneration', 'Neural Pathways', 'Neurotrophin 3', 'Rats', 'Rats, In... | 12,676,157 | [['B04.280.030'], ['B01.050'], ['E02.095.147.725.090', 'E04.525.090', 'E04.936.580.090'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['E05.393.350'], ['G05.360.337'], ['G12.875.545.340'], ['A11.284.180.075.249', 'A11.284.180.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Association rate constants rationalise the pharmacodynamics of apixaban and rivaroxaban. | Rivaroxaban and apixaban are selective direct inhibitors of free and prothrombinase-bound factor Xa (FXa). Surprisingly prothrombin time (PT) is little sensitive to clinically relevant changes in drug concentration, especially with apixaban. To investigate this pharmacodynamic discrepancy we have compared the kinetics ... | ['Blood Coagulation', 'Computer Simulation', 'Factor Xa Inhibitors', 'Half-Life', 'Humans', 'Hydrogen-Ion Concentration', 'Kinetics', 'Models, Biological', 'Prothrombin Time', 'Pyrazoles', 'Pyridones', 'Rivaroxaban', 'Thrombin'] | 25,761,505 | [['G09.188.390.150'], ['L01.224.160'], ['D27.505.519.389.745.800.449.500', 'D27.505.954.502.119.500.500'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['E05.599.395'], ['E01.370.225.625.115.610', 'E05.200.625.115.610', 'G09.188.680'], ['D03.383.129.539'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Kin discrimination and the benefit of helping in cooperatively breeding vertebrates. | In many cooperatively breeding vertebrates, a dominant breeding pair is assisted in offspring care by nonbreeding helpers. A leading explanation for this altruistic behavior is Hamilton's idea that helpers gain indirect fitness benefits by rearing relatives (kin selection). Many studies have shown that helpers typicall... | ['Altruism', 'Animals', 'Behavior, Animal', 'Birds', 'Breeding', 'Cooperative Behavior', 'Family', 'Female', 'Helping Behavior', 'Male', 'Mammals', 'Probability', 'Sexual Behavior, Animal', 'Social Behavior', 'Species Specificity'] | 14,576,431 | [['F01.145.813.090'], ['B01.050'], ['F01.145.113'], ['B01.050.150.900.248'], ['E05.820.150', 'G05.090'], ['F01.145.813.115'], ['F01.829.263', 'I01.880.853.150'], ['F01.145.813.225'], ['B01.050.150.900.649'], ['E05.318.740.600', 'G17.680', 'N05.715.360.750.625', 'N06.850.520.830.600'], ['F01.145.113.252.748'], ['F01.145... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Isolation of leukotriene C4 from human seminal fluid. | LTC4 was isolated and characterized from seminal fluid of seven human volunteers. A compound with a similar retention time to that of synthetic LTC4 was obtained using reverse-phase high performance liquid chromatography. The ultraviolet absorbance of the extracted substance was identical to synthetic LTC4. Furthermore... | ['Animals', 'Biological Assay', 'Chromatography, High Pressure Liquid', 'Chromones', 'Dinoprostone', 'Guinea Pigs', 'Humans', 'Ileum', 'Lung', 'Male', 'Muscle Contraction', 'Prostaglandins B', 'Prostaglandins E', 'SRS-A', 'Semen', 'Spectrophotometry, Ultraviolet'] | 6,597,495 | [['B01.050'], ['E05.091'], ['E05.196.181.400.300'], ['D03.383.663.283.266', 'D03.633.100.150.266'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['B01.050.150.900.649.313.992.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.684.249', 'A03.556.249.124'], ['A04.411'], ['G11.427.494... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reference intervals and age and gender dependency for arterial blood gases and electrolytes in adults. | BACKGROUND: Although results from blood gas analyzers are frequently used in clinical work surprisingly few and small studies have examined reference intervals for arterial blood gases and acid-base status. We have established reference values based on a large group of healthy people with a wide age distribution.METHOD... | ['Adult', 'Age Factors', 'Aged', 'Arteries', 'Blood Gas Analysis', 'Electrolytes', 'Female', 'Humans', 'Hydrogen-Ion Concentration', 'Male', 'Middle Aged', 'Oximetry', 'Reference Values', 'Sex Factors', 'Young Adult'] | 21,619,466 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['A07.015.114'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['D01.248'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['M01.060.116.630'], ['E01.370.225.124.100.100.600', 'E01.370.370.380.600'... | ['Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Proliferative and degenerative events in the early development of chick dorsal root ganglia. II. Responses to altered peripheral fields. | Responses of chick embryo dorsal root ganglia to early wing bud amputation were examined histologically using tritiated thymidine (3H-TdR) and autoradiography to analyze proliferation and the Feulgen procedure to visualize degenerating cells. Right wing buds were amputated at stage 15 or 16. At 4.5 to 9.5 days of incub... | ['Amputation', 'Animals', 'Chick Embryo', 'Forelimb', 'Ganglia, Spinal', 'Mitosis', 'Nerve Degeneration'] | 721,976 | [['E04.555.080'], ['B01.050'], ['A13.350.150', 'A16.331.200'], ['A13.395'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['G04.144.220.220.781', 'G05.113.220.781'], ['C23.550.737']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Carbon nanotube transistor controlled by a biological ion pump gate. | We report a hybrid bionanoelectronic transistor that has a local ATP-powered protein gate. ATP-dependent activity of a membrane ion pump, Na(+)/K(+)-ATPase, embedded in a lipid membrane covering the carbon nanotube, modulates the transistor output current by up to 40%. The ion pump gates the device by shifting the pH o... | ['Adenosine Triphosphate', 'Biomimetic Materials', 'Equipment Design', 'Equipment Failure Analysis', 'Ion Channel Gating', 'Lipid Bilayers', 'Nanotechnology', 'Nanotubes, Carbon', 'Particle Size', 'Signal Processing, Computer-Assisted', 'Sodium-Potassium-Exchanging ATPase', 'Transistors, Electronic'] | 20,426,455 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['J01.637.087'], ['E05.320'], ['E05.325.192'], ['G02.111.820.400', 'G04.835.400', 'G07.265.625'], ['D10.570.510', 'J01.637.087.500.510'], ['H01.603', 'J01.897.520.600'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['G02.712'], ['L01.224... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. | We have previously shown that risperidone, an antipsychotic drug with high affinity for 5-hydroxytryptamine (5-HT)2A and dopamine (DA)2 receptors, as well as for alpha 2- and alpha 2-adrenoceptors, enhances 5-HT metabolism selectively in the rat frontal cortex (FC). To further study the influence of risperidone on cent... | ['Adrenergic alpha-Antagonists', 'Animals', 'Antipsychotic Agents', 'Cerebral Cortex', 'Dopamine', 'Dose-Response Relationship, Drug', 'Idazoxan', 'Male', 'Piperazines', 'Pyridines', 'Raphe Nuclei', 'Rats', 'Risperidone', 'Serotonin'] | 9,194,049 | [['D27.505.519.625.050.200.100', 'D27.505.696.577.050.200.100'], ['B01.050'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['A08.186.211.200.885.287.500'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['G07.690.773.875', 'G07.690.936.50... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of 204 skin biopsies. | Current pathologic criteria cannot reliably distinguish cutaneous anaplastic large cell lymphoma from other CD30-positive T-cell lymphoproliferative disorders (lymphomatoid papulosis, systemic anaplastic large cell lymphoma with skin involvement, and transformed mycosis fungoides). We previously reported IRF4 (interfer... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Biopsy', 'Child', 'Child, Preschool', 'Diagnosis, Differential', 'Female', 'Humans', 'Immunohistochemistry', 'In Situ Hybridization, Fluorescence', 'Interferon Regulatory Factors', 'Lymphoma, Large-Cell, Anaplastic', 'Lymphoma, Primary Cutaneous... | 21,169,992 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['M01.060.406'], ['M01.060.406.448'], ['E01.171'], ['B01.050.150.900.649.313.98... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Laminar air flow isolation and decontamination: a prospective randomized study of the effects of prophylactic systemic antibiotics in bone marrow transplant patients. | 122 patients with hematologic malignancies underwent allogeneic marrow transplantation from HLA-matched sibling donors and received one of two forms of infection prophylaxis while granulocytopenic: 1) decontamination and laminar air flow isolation (LAF, 68 patients), and 2) LAF plus prophylactic systemic antibiotics (L... | ['Adolescent', 'Adult', 'Anti-Bacterial Agents', 'Bone Marrow Transplantation', 'Child', 'Child, Preschool', 'Environment, Controlled', 'Graft vs Host Disease', 'Granulocytes', 'Humans', 'Infection Control', 'Infections', 'Leukocyte Count', 'Middle Aged', 'Patient Isolation', 'Premedication', 'Prospective Studies', 'Pu... | 3,089,939 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.122.085'], ['E02.095.147.725.040', 'E04.936.580.040'], ['M01.060.406'], ['M01.060.406.448'], ['N06.230.150'], ['C20.452'], ['A11.118.637.415', 'A11.148.350', 'A11.627.340', 'A15.145.229.637.415', 'A15.378.316.340', 'A15.382.490.315'], ['B01.050.150.900.649.313.988.400.11... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The cell adhesion molecule L1 is developmentally regulated in the renal epithelium and is involved in kidney branching morphogenesis. | We immunopurified a surface antigen specific for the collecting duct (CD) epithelium. Microsequencing of three polypeptides identified the antigen as the neuronal cell adhesion molecule L1, a member of the immunoglobulin superfamily. The kidney isoform showed a deletion of exon 3. L1 was expressed in the mesonephric du... | ['Amino Acid Sequence', 'Animals', 'Ankyrins', 'Cell Adhesion', 'Epithelial Cells', 'Exons', 'Gene Expression Regulation, Developmental', 'Humans', 'Kidney', 'Leukocyte L1 Antigen Complex', 'Membrane Glycoproteins', 'Mesonephros', 'Molecular Sequence Data', 'Morphogenesis', 'Neural Cell Adhesion Molecules', 'Organ Cult... | 9,864,376 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.543.080'], ['G04.022'], ['A11.436'], ['G05.360.340.024.340.137.232'], ['G05.308.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['D12.776.157.125.750.500', 'D12.776.631.655.500', 'D23.050.301.562'], ['D12.776.395.550', 'D12.776... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Role of pilA, an essential regulatory gene of Neisseria gonorrhoeae, in the stress response. | Sequence analysis has shown that PilA, a transcriptional regulator of pilin gene expression in Neisseria gonorrhoeae, has extensive homology with the 54-kDa protein of the signal recognition particle of eukaryotes and its receptor, as well as with two proteins of Escherichia coli, FtsY and Ffh, which have been proposed... | ['Bacterial Outer Membrane Proteins', 'Bacterial Proteins', 'Biological Transport', 'DNA-Binding Proteins', 'Fimbriae Proteins', 'Gene Expression Regulation, Bacterial', 'Genes, Regulator', 'Heat-Shock Proteins', 'Neisseria gonorrhoeae'] | 1,522,071 | [['D12.776.097.120', 'D12.776.543.100'], ['D12.776.097'], ['G03.143'], ['D12.776.260'], ['D12.776.097.120.425', 'D12.776.543.100.300'], ['G05.308.300'], ['G05.360.340.024.340.425'], ['D12.776.580.216'], ['B03.440.400.425.550.550.474', 'B03.660.075.525.520.400']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
First-line therapy and methylation status of CHFR in serum influence outcome to chemotherapy versus EGFR tyrosine kinase inhibitors as second-line therapy in stage IV non-small-cell lung cancer patients. | The potential differential effect of first-line treatment and molecular mechanisms on survival to second-line chemotherapy or EGFR tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC) has not been fully investigated. In particular, CHFR is frequently methylated in NSCLC and may influence outcome. We ... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Carcinoma, Non-Small-Cell Lung', 'Cell Cycle Proteins', 'Cell Line, Tumor', 'Cell Proliferation', 'Cisplatin', 'ErbB Receptors', 'Erlotinib Hydrochloride', 'Female', 'Gene Expression Regulation, Neoplastic', 'Genes, ras', 'Humans', 'Lung Neoplasms', 'Male', 'Methylation', 'Mi... | 20,705,357 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['D12.776.167'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D08.811.913.696.620.682.725... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Bone marrow stromal cells co-modified with BMP-2 and bFGF gene]. | AIM: To establish modified bone marrow stromal cells(BMSCs) which can express BMP-2 and bFGF stably.METHODS: BMP-2 and bFGF gene were amplified by RT-PCR, and then cloned into the expression vector pcDNA3.0. After being confirmed by DNA sequencing, pcDNA3.0-BMP-2 and pcDNA3.0-bFGF were co-transfected into rat BMSCs wit... | ['Animals', 'Bone Marrow Cells', 'Bone Morphogenetic Protein 2', 'Cells, Cultured', 'Fibroblast Growth Factor 2', 'Gene Expression', 'Gene Transfer Techniques', 'Rats', 'Rats, Sprague-Dawley', 'Stromal Cells'] | 16,507,241 | [['B01.050'], ['A11.148', 'A15.378.316'], ['D12.644.276.954.200.200', 'D12.776.467.942.200.200', 'D23.529.942.200.200'], ['A11.251'], ['D12.644.276.624.120', 'D12.776.467.624.120', 'D23.529.624.120'], ['G05.297'], ['E05.393.350'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.75... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells. | TNF-like weak inducer of apoptosis (TWEAK) and fibroblast growth factor (FGF)-inducible 14 (Fn14) are a TNF superfamily ligand-receptor pair involved in many cellular processes including proliferation, migration, differentiation, inflammation, and angiogenesis. The Fn14 receptor is expressed at relatively low levels in... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Cell Line, Tumor', 'Female', 'Gene Expression Regulation, Neoplastic', 'HMGB1 Protein', 'HT29 Cells', 'Humans', 'Immunoconjugates', 'Injections, Intravenous', 'Jurkat Cells', 'Mice', 'Mice, Nude', 'Neoplasms', 'Protein Binding', 'Receptors, Tumor Necrosis Factor', 'Rib... | 21,586,630 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['G05.308.370'], ['D12.776.260.356.300', 'D12.776.660.235.400.600.300', 'D12.776.664.235.400.600.300'], ['A11.251.210.190.475', 'A11.251.860.180.475', 'A11.436.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.77... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bosutinib, dasatinib, imatinib, nilotinib, and ponatinib differentially affect the vascular molecular pathways and functionality of human endothelial cells. | The tyrosine kinase inhibitors (TKIs), nilotinib, ponatinib, and dasatinib (but not bosutinib or imatinib), are associated with vascular adverse events (VAEs) in chronic myeloid leukemia (CML). Though the mechanism is inadequately understood, an effect on vascular cells has been suggested. We investigated the effect of... | ['Aniline Compounds', 'Antineoplastic Agents', 'Cell Culture Techniques', 'Cell Survival', 'Dasatinib', 'Endothelium, Vascular', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Imatinib Mesylate', 'Imidazoles', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Neovascularization, Physiologic', 'Nitriles', 'Prot... | 29,741,440 | [['D02.092.146'], ['D27.505.954.248'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.346'], ['D02.886.675.184', 'D03.383.129.708.198', 'D03.383.742.148'], ['A07.015.700.500', 'A10.272.491.355'], ['A11.436.275.682'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.065.277.456... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibition of bile-salt-induced hepatocyte apoptosis by the antioxidant lazaroid U83836E. | Intracellular retention of toxic bile salts contributes to hepatocellular injury during cholestasis. We have recently demonstrated that toxic bile salts directly induce apoptosis in hepatocytes. As oxidative stress has been implicated in many models of apoptosis, our aim was to determine if oxidative injury is a critic... | ['Animals', 'Antioxidants', 'Apoptosis', 'Cell Nucleus', 'Cells, Cultured', 'Cholestasis', 'Chromans', 'DNA Fragmentation', 'Glycochenodeoxycholic Acid', 'Lipid Peroxidation', 'Liver', 'Oxidative Stress', 'Piperazines', 'Rats'] | 9,007,040 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G04.146.954.035'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.251'], ['C06.130.120.135'], ['D03.383.663.283.240', 'D03.633.100.150.240'], ['G05.200.230'], ['D04.210.500.105.225.272.150.350', 'D04.210.500.105.225.272.411.360', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Human epidermal growth factor receptor signaling contributes to tumor growth via angiogenesis in her2/neu-expressing experimental Wilms' tumor. | BACKGROUND: The human epidermal growth factor family (HER) members play a significant role in the mesenchymal-to-epithelial transition during renal tubulogenesis. HER misexpression has been linked also to loss of growth control, invasiveness, and promotion of angiogenesis in breast cancers and other human malignant tum... | ['Animals', 'Antibodies, Monoclonal', 'Antibodies, Monoclonal, Humanized', 'Cell Division', 'Cell Line, Tumor', 'Female', 'Genes, erbB-2', 'Humans', 'Kidney Neoplasms', 'Mice', 'Mice, Nude', 'Neoplasm Proteins', 'Neovascularization, Pathologic', 'Receptor, ErbB-2', 'Trastuzumab', 'Wilms Tumor', 'Xenograft Model Antitum... | 14,614,702 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210.190', 'A11.251.8... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preclinical studies of a panel of 12 monoclonal antibodies in view of bone marrow purging in acute lymphoblastic leukemia. | We analysed the optimal conditions for autologous bone marrow purging using complement binding monoclonal antibodies (mAbs). Twelve mAbs belonging to four clusters (CD9, CD10, CD19, CD24), alone or combined were evaluated by using direct cytotoxicity and clonogenic assays. We observed the following data: (1) optimal cy... | ['Antibodies, Monoclonal', 'Antigens, Neoplasm', 'Antigens, Surface', 'Bone Marrow', 'Bone Marrow Transplantation', 'Cell Count', 'Complement System Proteins', 'Fluorescent Antibody Technique', 'Humans', 'Leukemia, Lymphoid', 'Neprilysin', 'Transplantation, Autologous'] | 2,961,950 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.285'], ['D23.050.301'], ['A15.382.216'], ['E02.095.147.725.040', 'E04.936.580.040'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['D12.776.124.486.274'], ['E01.370.225.500.607.512.240', 'E... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rehydration driven RNAi: a novel approach for effectively delivering dsRNA to mosquito larvae. | The soft bodies and aquatic habitats of mosquito larvae pose a challenge for applying standard RNA-interference techniques to silence expression of target genes. Here we describe a novel technique for delivering double-stranded RNA into mosquito larvae by exploiting the larva's dehydration tolerance. Larvae were dehydr... | ['Animals', 'Culex', 'HSP90 Heat-Shock Proteins', 'Larva', 'RNA Interference', 'RNA, Double-Stranded', 'Transfection', 'Water'] | 22,308,791 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750.712.500.875.225'], ['D12.776.580.216.380'], ['B05.500.500', 'G07.345.500.550.500.500'], ['G05.308.203.374.790'], ['D13.444.735.490', 'G02.111.570.820.486.775', 'G05.360.580.775'], ['E05.393.350.810', 'G05.728.860'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of light-emitting diode (LED) curing modes on resin/dentin bond strength. | PURPOSE: This study aimed to compare the effect of three curing modes of a high-powered curing-light source on the shear bond strength and marginal gap of light- and dual-cured adhesive resin cements to dentin.MATERIALS AND METHODS: Twelve freshly extracted intact human mandibular molars were selected for this study an... | ['Acid Etching, Dental', 'Adhesiveness', 'Bisphenol A-Glycidyl Methacrylate', 'Ceramics', 'Composite Resins', 'Curing Lights, Dental', 'Dental Bonding', 'Dental Marginal Adaptation', 'Dental Materials', 'Dental Porcelain', 'Dental Stress Analysis', 'Dentin', 'Glass Ionomer Cements', 'Humans', 'Hydrofluoric Acid', 'Mate... | 19,682,222 | [['E06.931.475.111'], ['G02.860.139'], ['D02.241.081.069.600.150', 'D02.455.426.559.389.657.100', 'D05.750.716.822.308.200', 'D25.339.816.500.200', 'D25.720.716.822.308.200', 'J01.637.051.339.816.500.200', 'J01.637.051.720.716.822.308.200'], ['J01.637.153'], ['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Significant deterioration of anti-atherogenic efficacy of nebivolol in a double (apolipoprotein E and endothelial nitric oxide synthase) knockout mouse model of atherosclerosis in comparison to single (apolipoprotein E) knockout model. | Anti-atherogenic action of nebivolol in apolipoprotein E (apoE)-single knockout mouse model can be explained by its beneficial effect on endothelium, especially on endothelial nitric oxide synthase (eNOS). We, therefore, decided to use apoE and eNOS-double knockout mouse model to confirm that mechanism of nebivolol ben... | ['Animals', 'Aorta', 'Apolipoproteins E', 'Atherosclerosis', 'Benzopyrans', 'Cholesterol', 'Disease Models, Animal', 'Ethanolamines', 'Female', 'Mice, Knockout', 'Nebivolol', 'Nitric Oxide Synthase Type III', 'Triglycerides'] | 25,554,992 | [['B01.050'], ['A07.015.114.056'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['C14.907.137.126.307'], ['D03.383.663.283', 'D03.633.100.150'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D02.033.100.291', 'D02.033.37... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genetic markers for closely-related parasitic nematodes. | Seven species of closely-related nematode parasite (Trichostrongylus axei, T. colubriformis, T. probolurus, T. retortaeformis, T. rugatus, T. vitrinus and T. tenuis) were characterized using a polymerase chain reaction-linked restriction fragment length polymorphism technique (PCR-RFLP). The rDNA region spanning the fi... | ['Animals', 'DNA Restriction Enzymes', 'DNA, Helminth', 'DNA, Ribosomal', 'Genes, Helminth', 'Genetic Markers', 'Male', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length', 'Species Specificity', 'Trichostrongylus'] | 8,569,771 | [['B01.050'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['D13.444.308.315'], ['D13.444.308.475'], ['G05.360.340.024.340.310', 'G05.360.340.337.500'], ['D23.101.387', 'G05.695.450'], ['E05.393.620.500'], ['G05.365.795.595'], ['G16.824'], ['B01.050.500.500.294.400.968.746.610']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genetic variability of the low-molecular-weight glutenin subunits in spelt wheat (Triticum aestivum ssp. spelta L. em Thell.). | The low-molecular-weight glutenin subunit composition of a collection of 403 accessions of spelt wheat ( Triticum aestivum ssp. spelta L. em. Thell) was analyzed by SDS-PAGE. Extensive variation was found, including 46 different patterns for zone B and 16 for zone C. Patterns within zone B exhibited from two to six ban... | ['Electrophoresis, Polyacrylamide Gel', 'Genetic Variation', 'Glutens', 'Molecular Weight', 'Triticum'] | 14,614,566 | [['E05.196.401.402', 'E05.301.300.319'], ['G05.365'], ['D12.776.765.433.500.500', 'D12.776.765.725.500.500'], ['G02.494'], ['B01.650.940.800.575.912.250.822.918']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neuronal cell cultures as toxicologic test systems. | Neuronal cell cultures now represent well-characterized systems with which acute and chronic toxicologic effects of a variety of agents can be evaluated. Extensive synapse formation occurs over a period of days and weeks in these cell cultures and can be assayed semiquantitatively by morphological and electrophysiologi... | ['Action Potentials', 'Animals', 'Cells, Cultured', 'Central Nervous System', 'Etorphine', 'Mice', 'Neurons', 'Spinal Cord', 'Synapses', 'Time Factors', 'Toxicology', 'gamma-Aminobutyric Acid'] | 720,311 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['A11.251'], ['A08.186'], ['D03.132.577.249.270', 'D03.605.497.320', 'D03.633.400.686.320', 'D04.615.723.795.270'], ['B01.050.150.900.649.313.992.635.505.500'], ['A08.675', 'A11.671'], ['A08.186.854'], ['A08.850', 'A11.284.149.165.420.780'], ['G01.910... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Force time-history affects fatigue accumulation during repetitive handgrip tasks. | Muscle fatigue is associated with a higher risk of workplace injury, in particular during repetitive tasks. This study aimed to identify the effect of a complex force-time history (a task with multiple different submaximal effort levels) on fatigue accumulation and recovery during a handgrip task. We measured surface e... | ['Adult', 'Biomechanical Phenomena', 'Electromyography', 'Female', 'Hand Strength', 'Humans', 'Movement', 'Muscle Fatigue', 'Muscle, Skeletal'] | 25,465,984 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['E01.370.405.255', 'E01.370.530.255'], ['E01.370.600.425.500', 'G11.427.560.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.568', 'G11.427.410'], ['G11.427.550'], ['A02.633.567', 'A10.690.552.500']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The permeability of the skin of the aquatic anuran Xenopus laevis (Pipidae). | The undirectional transcutaneous fluxes of Na, Cl, water and urea were measured, in vitro, in the pipoid anuran Xenopus laevis. An active uptake (outside to inside) of Na was observed but Cl movements appeared to be passive. The effluxes of Na and Cl were low compared to those measured in other species of amphibians. T... | ['Animals', 'Biological Transport, Active', 'Chlorides', 'Permeability', 'Skin', 'Sodium', 'Urea', 'Vasotocin', 'Water', 'Xenopus'] | 624,899 | [['B01.050'], ['G03.143.310'], ['D01.210.450.150', 'D01.248.497.158.215'], ['G02.723'], ['A17.815'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850', 'D01.552.547.725'], ['D02.065.950'], ['D06.472.699.631.692.881', 'D12.644.548.691.692.881'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925'], [... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Epikeratoplasty for keratoconus. | The 6 eyes of 6 patients operated on using keratoconic epikeratoplasty are evaluated, and the mean 11-month postoperative results are reported. Uncorrected visual acuities improved in 4 patients and were maintained in 1 patient. One patient revealed a decrease of uncorrected visual acuity in the postoperative 6th month... | ['Adolescent', 'Adult', 'Corneal Transplantation', 'Female', 'Follow-Up Studies', 'Humans', 'Keratoconus', 'Male', 'Retrospective Studies', 'Treatment Outcome', 'Visual Acuity', 'Wound Healing'] | 1,942,600 | [['M01.060.057'], ['M01.060.116'], ['E02.095.147.725.225', 'E04.540.825.374', 'E04.936.580.225'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.204.627'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A signal detection theory analysis of behavioral pattern separation paradigms. | Behavioral pattern separation (BPS) paradigms ask participants to discriminate previously encoded (old) stimuli from highly similar (lure) and categorically distinct (novel) stimuli. The lure-old discrimination, thought to uniquely reflect pattern separation in the hippocampal formation, is typically pitted against the... | ['Female', 'Humans', 'Male', 'Models, Psychological', 'Neuropsychological Tests', 'ROC Curve', 'Recognition, Psychology', 'Signal Detection, Psychological', 'Young Adult'] | 26,179,230 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.695'], ['F04.711.513'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.700.680', 'N06.850.520.445.800.750'], ['F02.463.425.540.706'], ['E01.370.685.814', 'E05.796.908', 'F02.463.593.257.800', 'F02.463.593.710.725', 'F04.096.753.814', 'F04.669.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Distribution of risk factors according to socioeconomic status in male and female cases with coronary artery disease]. | OBJECTIVE: Socioeconomic status (SES) is associated with coronary artery disease (CAD) risk factors, coronary morbidity and mortality. In industrialized countries several studies showed that the lowest SES groups have higher coronary morbidity and mortality rates and higher coronary risk factors profile. The aim of our... | ['Aged', 'Coronary Artery Disease', 'Female', 'Humans', 'Male', 'Middle Aged', 'Obesity', 'Prevalence', 'Risk Factors', 'Sex Factors', 'Socioeconomic Factors', 'Turkey'] | 15,590,357 | [['M01.060.116.100'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['E05.318.308.985.525.750', 'N01.224.935.59... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Synthesis of high-molar-activity [18 | [18F]6-fluoro-L-DOPA ([18F]FDOPA) is a diagnostic radiopharmaceutical for positron emission tomography (PET) imaging that is used to image Parkinson's disease, brain tumors, and focal hyperinsulinism of infancy. Despite these important applications, [18F]FDOPA PET remains underutilized because of synthetic challenges a... | ['Boronic Acids', 'Chemistry Techniques, Synthetic', 'Copper', 'Dihydroxyphenylalanine', 'Fluorine Radioisotopes', 'Glycols', 'Halogenation'] | 32,269,382 | [['D01.029.260.110', 'D01.132.285', 'D02.203.200'], ['E05.197', 'J01.897.836.249'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D02.092.311.200', 'D02.455.426.559.389.657.166.175.200', 'D12.125.072.050.685.400', 'D12.125.072.050.875.130'], ['D01.496.749.340'], ['D02.033.455'], ['G02.111.323', 'G03.360'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Chronic dizziness in a pain patient--pharmacogenomic identification of tramadol as cause]. | This casuistic reports on a 59-year-old pain patient taking normal dosage Tramadol as analgetic drug, who suffered from chronic dizziness leading to immobilisation for more than 9 months. On admission to inpatient rehabilitation Tramadol was removed in exchange for morphine sulphate with the unexpected result of a prom... | ['Analgesics, Opioid', 'Anti-Inflammatory Agents, Non-Steroidal', 'Chemotherapy, Adjuvant', 'Cytochrome P-450 CYP2D6', 'Delayed-Action Preparations', 'Dipyrone', 'Dizziness', 'Drug Therapy, Combination', 'Genes, Duplicate', 'Humans', 'Male', 'Mesothelioma', 'Middle Aged', 'Morphine', 'Pain', 'Pain Measurement', 'Pain, ... | 21,140,323 | [['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['E02.186.170', 'E02.319.170'], ['D08.244.453.005.600', 'D08.244.453.491.372', 'D08.811.682.690.708.170.010.60... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Tibiofemoral kinematics and condylar motion during the stance phase of gait. | Accurate knowledge of the dynamic knee motion in-vivo is instrumental for understanding normal and pathological function of the knee joint. However, interpreting motion of the knee joint during gait in other than the sagittal plane remains controversial. In this study, we utilized the dual fluoroscopic imaging techniqu... | ['Adult', 'Biomechanical Phenomena', 'Female', 'Femur', 'Gait', 'Humans', 'Knee Joint', 'Male', 'Middle Aged', 'Motion', 'Tibia', 'Walking'] | 19,497,573 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['A02.835.232.043.150'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['M01.060.116.630'], ['G01.482'], ['A02.835.232.043.650.883'], ['G11.427.410.568.900', 'G11.427.410.698.277.937', 'I03.350.937'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
International medical graduates' reflections on facilitators and barriers to undertaking the Australian medical council examination. | OBJECTIVE: In Australia, 25% of international medical graduates (IMGs) make up the medical workforce. Concern is expressed in the literature about the lack of awareness and knowledge of issues that impinge on IMGs' education. Although there is literature alluding to difficulties IMGs face with undertaking the Australia... | ['Australia', 'Clinical Competence', 'Educational Measurement', 'Foreign Medical Graduates', 'Humans', 'Interviews as Topic'] | 22,935,121 | [['Z01.639.100', 'Z01.678.100.373'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.399'], ['M01.526.407.435', 'M01.526.485.810.390', 'N02.360.810.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420']] | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Activation of caspase-3 and c-Jun NH2-terminal kinase signaling pathways involving heroin-induced neuronal apoptosis. | Heroin has been shown to cause spongiform leukoencephalopathy (SLE) in heroin addicts. In this study, we found that heroin could induce apoptosis of primary cultured cerebellar granule cells (CGC) and c-Jun N-terminal kinase (JNK) pathway is activated during CGCs apoptosis. Inhibiting JNK with a specific inhibitor, SP6... | ['Animals', 'Animals, Newborn', 'Apoptosis', 'Caspase 3', 'Caspase Inhibitors', 'Cerebellum', 'Cytoplasmic Granules', 'Disease Models, Animal', 'Enzyme Activation', 'Heroin', 'Heroin Dependence', 'MAP Kinase Signaling System', 'Mitogen-Activated Protein Kinase 8', 'Narcotics', 'Neurons', 'Primary Cell Culture', 'Rats',... | 21,856,377 | [['B01.050'], ['B01.050.050.282'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D27.505.519.389.745.325.500'], ['A08.186.211.132.810.428.200'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antemortem diagnosis and successful management of noncompressive segmental myelopathy in a Siberian-Bengal mixed breed tiger. | A 10-yr-old female spayed mixed breed tiger presented for a 9-day history of acute and nonprogressive paralysis of the pelvic limbs. Magnetic resonance imaging revealed a lesion suggestive of fibrocartilaginous embolic myelopathy with regional spinal cord edema, decreased disk signal intensity at L2-L3, and mild interv... | ['Animals', 'Anti-Ulcer Agents', 'Cartilage Diseases', 'Dexamethasone', 'Embolism', 'Gastritis', 'Glucocorticoids', 'Spinal Cord Diseases', 'Sucralfate', 'Tigers'] | 24,450,082 | [['B01.050'], ['D27.505.954.483.203'], ['C05.182', 'C17.300.182'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['C14.907.355.350'], ['C06.405.205.697', 'C06.405.748.398'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['C10.228.854'], ['D02.886.740.299', 'D09.698.629.305.770.850', 'D09.947.750.770.850'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis, intracellular processing and secretion of thrombospondin in human endothelial cells. | The biosynthesis of thrombospondin, a glycoprotein first described in platelets, has been studied in human endothelial cells. This glycoprotein has a molecular mass of 450 kDa. It is secreted and incorporated into the extracellular matrix of several cell types in culture. Pulse-chase experiments with [3H]leucine were p... | ['Acetylglucosaminidase', 'Blood Platelets', 'Carbohydrate Metabolism', 'Cells, Cultured', 'Chromatography, Affinity', 'Chromatography, Gel', 'Electrophoresis, Polyacrylamide Gel', 'Endothelium', 'Glycoproteins', 'Glycoside Hydrolases', 'Humans', 'Hydrolysis', 'Immunochemistry', 'Mannosyl-Glycoprotein Endo-beta-N-Acety... | 3,935,437 | [['D08.811.277.450.483.180.500'], ['A11.118.188', 'A15.145.229.188'], ['G02.111.158', 'G03.191'], ['A11.251'], ['E05.196.181.400.170'], ['E05.196.181.400.250'], ['E05.196.401.402', 'E05.301.300.319'], ['A10.272.491'], ['D09.400.430', 'D12.776.395'], ['D08.811.277.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The triakontatetraneuropeptide TTN increases [CA2+]i in rat astrocytes through activation of peripheral-type benzodiazepine receptors. | Astrocytes synthesize a series of regulatory peptides called endozepines, which act as endogenous ligands of benzodiazepine receptors. We have recently shown that one of these endozepines, the triakontatetraneuropeptide TTN, stimulates DNA synthesis in astroglial cells. The purpose of the present study was to determine... | ['Animals', 'Animals, Newborn', 'Astrocytes', 'Binding Sites', 'Calcium', 'Calcium Channel Blockers', 'Calcium Channels, L-Type', 'Calcium Signaling', 'Cells, Cultured', 'Central Nervous System', 'Cytosol', 'Membrane Potentials', 'Neuropeptides', 'Patch-Clamp Techniques', 'Peptide Fragments', 'Radioligand Assay', 'Rats... | 11,460,265 | [['B01.050'], ['B01.050.050.282'], ['A08.637.200', 'A11.650.200'], ['G02.111.570.120'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['D12.776.157.530.400.150.400', 'D12.776.543.550.450.150.400', 'D12.776.543.585.400.150.400'], ['G02.111.8... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sampling through time and phylodynamic inference with coalescent and birth-death models. | Many population genetic models have been developed for the purpose of inferring population size and growth rates from random samples of genetic data. We examine two popular approaches to this problem, the coalescent and the birth–death-sampling model (BDM), in the context of estimating population size and birth rates i... | ['Animals', 'Death', 'Genetics, Population', 'Humans', 'Models, Genetic', 'Parturition'] | 25,401,173 | [['B01.050'], ['C23.550.260'], ['H01.158.273.343.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.397'], ['G08.686.784.769.490']] | ['Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Capillary electrophoresis-mass spectrometry reveals the distribution of carbon metabolites during nitrogen starvation in Synechocystis sp. PCC 6803. | Nitrogen availability is one of the most important factors for the survival of cyanobacteria. Previous studies on Synechocystis revealed a contradictory situation with regard to metabolism during nitrogen starvation; that is, glycogen accumulated even though the expressions of sugar catabolic genes were widely upregula... | ['Carbohydrate Metabolism', 'Carbon', 'Citric Acid Cycle', 'Electrophoresis, Capillary', 'Gene Expression Regulation, Bacterial', 'Glycogen', 'Mass Spectrometry', 'Metabolome', 'Nitrogen', 'Purines', 'Pyrimidines', 'Starvation', 'Synechocystis'] | 23,796,428 | [['G02.111.158', 'G03.191'], ['D01.268.150'], ['G02.111.165', 'G03.295.342', 'G03.493.170'], ['E05.196.401.190', 'E05.301.300.190'], ['G05.308.300'], ['D05.750.078.562.388', 'D09.698.365.388'], ['E05.196.566'], ['G03.500'], ['D01.268.604', 'D01.362.625'], ['D03.633.100.759'], ['D03.383.742'], ['C18.654.521.750'], ['B03... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute diarrhoeal disease in children under 7 years of age in a peri-urban slum of Santiago, Chile. | A group of 168 families who lived in a peri-urban slum in Santiago were surveyed for 9 months. All of them had a child under 7 years of age. Medical activities and data collection were carried out at a Field Station and by means of twice-weekly visits to each home, at which time cases of diarrhoea were recorded and inv... | ['Age Factors', 'Bacterial Infections', 'Child', 'Child, Preschool', 'Chile', 'Diarrhea', 'Feces', 'Humans', 'Hygiene', 'Infant', 'Rotavirus Infections', 'Social Class', 'Urban Population'] | 4,067,299 | [['N05.715.350.075', 'N06.850.490.250'], ['C01.150.252'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.107.757.235'], ['C23.888.821.214'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.547', 'N06.850.670'], ['M01.060.703'], ['C01.925.782.791.814'], ['I01.880.853.996.755', 'N01.824.782'], ['N01.600.... | ['Health Care [N]', 'Diseases [C]', 'Named Groups [M]', 'Geographicals [Z]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
What is eupnea. | Respiratory neuronal networks in vertebrates appear to be able to generate a variety of rhythmic patterns in vivo, leading to the biological diversity of eupneic patterns as well as to life-threatening dyspneic patterns. Eupnea is best viewed as the collection of respiratory strategies preventing potential dyspneas, th... | ['Adaptation, Physiological', 'Animals', 'Apnea', 'Brain', 'Dyspnea', 'Humans', 'Hypoxia', 'Neurobiology', 'Respiration', 'Respiratory Physiological Phenomena'] | 14,637,315 | [['G07.025', 'G16.012.500'], ['B01.050'], ['C08.618.085', 'C23.888.852.130'], ['A08.186.211'], ['C08.618.326', 'C23.888.852.371'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079'], ['H01.158.273.610', 'H01.158.610.080'], ['G09.772.705'], ['G09.772']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Do Skin Perforator Flaps Accommodate Foot Growth in Children after Reconstruction? | Backgrounds Whether or not the flap accommodates growth is unpredictable and remains to be determined. We hypothesized that perforator flaps may accommodate growth after reconstruction in children and evaluated change of the flap after foot and ankle reconstruction. Methods A retrospective review of 28 children from 20... | ['Adolescent', 'Ankle', 'Ankle Injuries', 'Child', 'Child, Preschool', 'Female', 'Foot', 'Foot Injuries', 'Humans', 'Male', 'Perforator Flap', 'Range of Motion, Articular', 'Reconstructive Surgical Procedures', 'Reproducibility of Results', 'Retrospective Studies', 'Soft Tissue Injuries', 'Treatment Outcome'] | 27,367,806 | [['M01.060.057'], ['A01.378.610.050'], ['C26.558.100'], ['M01.060.406'], ['M01.060.406.448'], ['A01.378.610.250'], ['C26.558.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.850.710.750', 'E07.862.710.750'], ['E01.370.600.700', 'G11.427.760'], ['E04.680'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.32... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Diagnostic significance of tests with toxoplasmin in clinical practice]. | Intracutaneous test (ICT) with toxoplasmin is a technically simple and inexpensive method of laboratory diagnosis of toxoplasmosis. Of the 5472 examined sick persons, 54.28 percent displayed a positive ICT. With a positive ICT, any titer of any serological reaction of toxoplasmosis is regarded as a diagnostic titer. | ['Animals', 'Antibodies, Protozoan', 'Antigen-Antibody Reactions', 'Humans', 'Immune Sera', 'Immunoassay', 'Immunoglobulins', 'Serologic Tests', 'Skin Tests', 'Toxoplasma', 'Toxoplasmosis'] | 12,889,370 | [['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['G12.122'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.573', 'D12.776.377.715.548.114.573', 'D20.215.401'], ['E05.478.566', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol. | Genome-wide association (GWA) studies represent a powerful strategy for identifying susceptibility genes for complex diseases in human populations but results must be confirmed and replicated. Because of the close homology between mouse and human genomes, the mouse can be used to add evidence to genes suggested by huma... | ['Amino Acid Sequence', 'Animals', 'Cholesterol, HDL', 'Chromosome Mapping', 'Computational Biology', 'Gene Expression Profiling', 'Genome', 'Genome, Human', 'Genome-Wide Association Study', 'Haplotypes', 'Humans', 'Mice', 'Mice, Inbred Strains', 'Molecular Sequence Data', 'Quantitative Trait Loci', 'Sequence Homology'... | 21,444,760 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['E05.393.183'], ['H01.158.273.180', 'L01.313.124'], ['E05.393.332'], ['G05.360.340'], ['G05.360.340.350'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Structural and Kinetic Characteristics of 1,4-Dioxane-Degrading Bacterial Consortia Containing the Phylum TM7. | 1,4-Dioxane-degrading bacterial consortia were enriched from forest soil (FS) and activated sludge (AS) using a defined medium containing 1,4-dioxane as the sole carbon source. These two enrichments cultures appeared to have inducible tetrahydrofuran/dioxane and propane degradation enzymes. According to qPCR results on... | ['Bacteria', 'Bacterial Proteins', 'Biodegradation, Environmental', 'Dioxanes', 'Kinetics', 'Microbial Consortia', 'Mixed Function Oxygenases', 'Phylogeny', 'Sewage', 'Soil Microbiology'] | 27,470,275 | [['B03'], ['D12.776.097'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['D03.383.188'], ['G01.374.661', 'G02.111.490'], ['G06.591.750', 'G16.500.275.157.049.100.500.750', 'N06.230.124.049.100.500.500'], ['D08.811.682.690.708'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D20.944.932.500'], ['H01.158.273.540.274.55... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Ethanol-induced limb defects in mice: effect of strain and Ro15-4513. | It is now thought that ethanol exerts many of its behavioral effects in the CNS by interaction with the gamma-aminobutyric acid (GABA) receptor, and it has been shown that the benzodiazepine reverse agonist Ro15-4513 reverses some of the CNS effects produced by ethanol. The hypothesis was tested that ethanol exerts its... | ['Abnormalities, Drug-Induced', 'Animals', 'Azides', 'Benzodiazepines', 'Ethanol', 'Female', 'Fetal Resorption', 'Forelimb', 'Maternal-Fetal Exchange', 'Mice', 'Mice, Inbred C57BL', 'Pregnancy', 'Radiography', 'Receptors, GABA-A'] | 2,160,130 | [['C16.131.042'], ['B01.050'], ['D01.625.100', 'D02.159'], ['D03.633.100.079.080'], ['D02.033.375'], ['C13.703.223.300', 'C23.550.260.585.260'], ['A13.395'], ['G08.686.784.769.455'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['G08.68... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Detection of DNA damage induced by apoptosis in the rat brain following incomplete ischemia. | To clarify the pathogenesis and molecular basis of ischemia-related nerve cell death, we examined the occurrence of DNA fragmentation as a hallmark of apoptotic cell death following incomplete ischemia in the rat brain by means of in situ end labeling of fragmented DNA. Incomplete ischemia was produced by permanently o... | ['Animals', 'Apoptosis', 'Cerebral Cortex', 'DNA Damage', 'Deoxyribonuclease I', 'Ischemic Attack, Transient', 'Male', 'Prosencephalon', 'Rats', 'Rats, Wistar'] | 7,609,899 | [['B01.050'], ['G04.146.954.035'], ['A08.186.211.200.885.287.500'], ['G05.200'], ['D08.811.277.352.335.350.250'], ['C10.228.140.300.150.836', 'C14.907.253.092.836'], ['A08.186.211.200'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Microneedle delivery of trivalent influenza vaccine to the skin induces long-term cross-protection. | A painless self-immunization method with effective and broad cross-protection is urgently needed to prevent infections against newly emerging influenza viruses. In this study, we investigated the cross-protection efficacy of trivalent influenza vaccine containing inactivated A/PR/8/34 (H1N1), A/Hong Kong/68 (H3N2) and ... | ['Animals', 'Female', 'Immunoglobulin G', 'Influenza A Virus, H1N1 Subtype', 'Influenza A Virus, H3N2 Subtype', 'Influenza Vaccines', 'Injections, Intradermal', 'Mice, Inbred BALB C', 'Needles', 'Orthomyxoviridae Infections'] | 26,957,023 | [['B01.050'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['B04.820.480.968.405.400.214'], ['B04.820.480.968.405.400.300'], ['D20.215.894.899.302'], ['E02.319.267.530.620.410'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.33... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The partograph for the prevention of obstructed labor. | Obstructed labor is an important cause of maternal and perinatal mortality and morbidity. The partograph graphically represents key events in labor and provides an early warning system. The World Health Organization partographs are the best known partographs in low resource settings. Experiences with World Health Organ... | ['Decision Making', 'Female', 'Fetal Monitoring', 'Humans', 'Labor, Obstetric', 'Maternal Mortality', 'Obstetric Labor Complications', 'Pregnancy', 'Uterine Contraction', 'World Health Organization'] | 19,407,533 | [['F02.463.785.373'], ['E01.370.378.230', 'E01.370.520.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769.326'], ['E05.318.308.985.550.500', 'N01.224.935.698.653', 'N06.850.505.400.975.550.500', 'N06.850.520.308.985.550.500'], ['C13.703.420'], ['G08.686.784.769'], ['G08.686.784.769.326.700', 'G11... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Control of Auditory Attention in Children With Specific Language Impairment. | PURPOSE: Children with specific language impairment (SLI) appear to demonstrate deficits in attention and its control. Selective attention involves the cognitive control of attention directed toward a relevant stimulus and simultaneous inhibition of attention toward irrelevant stimuli. The current study examined attent... | ['Acoustic Stimulation', 'Attention', 'Auditory Perception', 'Child', 'Executive Function', 'Female', 'Humans', 'Inhibition, Psychological', 'Language Disorders', 'Male', 'Psychological Tests', 'Reaction Time'] | 26,262,428 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['F02.830.104.214'], ['F02.463.593.071', 'G07.888.125'], ['M01.060.406'], ['F02.463.217'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.544', 'F02.463.425.475', 'F02.739.794.405'], ['C10.597.606.150.500', 'C23.888.592.604.150.500'], ['F04.711'], ['E05.796.81... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
PredHydroxy: computational prediction of protein hydroxylation site locations based on the primary structure. | Compared to well-known and extensively studied protein phosphorylation, protein hydroxylation attracts much less attention and the molecular mechanism of the hydroxylation is still incompletely understood. And yet annotation of hydroxylation in proteomes is a first-critical step toward decoding protein function and und... | ['Amino Acid Sequence', 'Amino Acids', 'Computational Biology', 'Hydroxylation', 'Position-Specific Scoring Matrices', 'Proteins', 'ROC Curve', 'Reproducibility of Results', 'Software', 'Support Vector Machine', 'Web Browser'] | 25,534,958 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.125'], ['H01.158.273.180', 'L01.313.124'], ['G02.111.385', 'G02.607.348', 'G03.425'], ['E05.318.740.600.650', 'E05.393.760.670', 'G02.111.570.580.175.500'], ['D12.776'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.700.680', 'N06.850.520.445.800.750'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I/IGFBP-1 concentrations. | The present study tests the clinical postulate that elevated testosterone (Te) and estradiol (E2) concentrations modulate the effects of constant iv infusion of saline vs. recombinant human IGF-I on free IGF-I, IGF binding protein (IGFBP)-1, and dimeric IGF-I/IGFBP-1 concentrations in healthy aging adults. To this end,... | ['Aged', 'Cross-Over Studies', 'Dimerization', 'Estradiol', 'Female', 'Humans', 'Insulin-Like Growth Factor Binding Protein 1', 'Insulin-Like Growth Factor Binding Proteins', 'Insulin-Like Growth Factor I', 'Male', 'Middle Aged', 'Pregnancy Proteins', 'Prospective Studies', 'Testosterone'] | 15,713,723 | [['M01.060.116.100'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['G02.206', 'G03.230'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.420.250'], ['D12.776.157.420'], ['D12.644.276.937.400', 'D12.776.124.862.400', 'D12.776.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Assessing the risk of Alzheimer's disease in first-degree relatives of Alzheimer's disease cases. | Family history of Alzheimer's disease (AD) was investigated using a telephone reinterview of 99 cases and 116 controls selected from a case-control study of 170 matched pairs. It was found that the family history method used in the initial interview was satisfactory in identifying first-degree relatives and assessing t... | ['Age of Onset', 'Aged', 'Alzheimer Disease', 'Australia', 'Case-Control Studies', 'Data Collection', 'Family', 'Female', 'Humans', 'Male', 'Pedigree', 'Reproducibility of Results', 'Risk Factors'] | 8,134,515 | [['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['Z01.639.100', 'Z01.678.100.373'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Direct and indirect costs attributable to osteoarthritis in active subjects. | OBJECTIVE: To estimate the direct and indirect costs of osteoarthritis (OA) in an active population, and to identify factors significantly influencing these expenditures.METHODS: A cohort of 3,440 subjects employed by the Li?ge City Council was followed prospectively for 6 months. Subjects were asked to report monthly ... | ['Adult', 'Belgium', 'Cost of Illness', 'Disability Evaluation', 'Employment', 'Female', 'Health Expenditures', 'Health Status', 'Humans', 'Male', 'Middle Aged', 'Osteoarthritis', 'Quality of Life', 'Severity of Illness Index'] | 16,755,664 | [['M01.060.116'], ['Z01.542.115'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['E01.370.400'], ['N01.824.245'], ['N03.219.151.450', 'N05.300.385'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'],... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Theory development should begin (but not end) with good empirical fits: a comment on Roberts and Pashler (2000). | S. Roberts and H. Pashler (2000) argued against using goodness of fit as evidence to support theories. The authors agree with their suggestions for how to go beyond good fits but disagree with their starting point. In this comment, the authors argue that good fits are part and parcel of theory development, that they ar... | ['Decision Support Techniques', 'Humans', 'Models, Psychological', 'Psychological Theory', 'Social Behavior'] | 12,088,247 | [['E05.245', 'L01.313.500.750.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.695'], ['F02.739'], ['F01.145.813']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Curcumin derivatives as metal-chelating agents with potential multifunctional activity for pharmaceutical applications. | Curcuminoids represent new perspectives for the development of novel therapeutics for Alzheimer's disease (AD), one probable mechanism of action is related to their metal complexing ability. In this work we examined the metal complexing ability of substituted curcuminoids to propose new chelating molecules with biologi... | ['Chelating Agents', 'Copper', 'Curcumin', 'Free Radical Scavengers', 'Gallium', 'Hydrogen-Ion Concentration', 'Models, Molecular', 'Molecular Conformation', 'Superoxides', 'Thermodynamics'] | 24,968,097 | [['D27.505.519.914.500', 'D27.720.832.500'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D02.455.326.146.485.222.222', 'D02.455.426.559.389.657.166.200', 'D02.455.426.559.694.222'], ['D27.505.519.217.500'], ['D01.268.556.289', 'D01.552.544.289'], ['G02.300'], ['E05.599.595'], ['G02.111.570.820'], ['D01... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A population-based case-control study of risk factors for neural tube defects in four high-prevalence areas of Shanxi province, China. | Shanxi province in Northern China has one of the highest reported prevalence rates of neural tube defects (NTD) in the world. To explore the risk factors for NTDs in Shanxi province, we carried out a population-based case-control study in four selected counties with prevalence rates >10 per 1000 births during 2003. Usi... | ['Adult', 'Anencephaly', 'Case-Control Studies', 'China', 'Encephalocele', 'Female', 'Humans', 'Logistic Models', 'Neural Tube Defects', 'Pregnancy', 'Pregnancy Complications', 'Prevalence', 'Risk Factors', 'Spinal Dysraphism'] | 16,420,340 | [['M01.060.116'], ['C10.500.680.196', 'C16.131.085.197', 'C16.131.666.680.196'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['Z01.252.474.164'], ['C10.500.680.488', 'C16.131.666.680.488', 'C23.300.707.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Genes significantly associated with lineage II food isolates of Listeria monocytogenes. | BACKGROUND: Listeria monocytogenes is a widespread foodborne pathogen that can cause listeriosis, a potentially fatal infection. L. monocytogenes is subdivided into four phylogenetic lineages, with the highest incidence of listeriosis occurring within lineage I followed by lineage II. Strains of L. monocytogenes differ... | ['Disease Outbreaks', 'Food Microbiology', 'Genes, Bacterial', 'Humans', 'Listeria monocytogenes', 'Listeriosis', 'Polymorphism, Single Nucleotide', 'Serogroup', 'Stress, Physiological', 'Virulence'] | 30,253,738 | [['N06.850.290'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.300', 'N06.850.425.200', 'N06.850.460.400.300', 'N06.850.601.500.249.300'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.353.500.500.500', 'B03.510.... | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
A qualitative evaluation of the impact of palliative care day services: the experiences of patients, informal carers, day unit managers and volunteer staff. | OBJECTIVES: To explore the experiences of people involved in UK palliative care day services (PCDS) and identify the important outcomes of this service.METHODS: Focus groups were carried out separately with patients, informal carers and volunteers from four purposively selected palliative care day units and with day un... | ['Adult', 'Aged', 'Caregivers', 'Day Care, Medical', 'Female', 'Focus Groups', 'Home Nursing', 'Humans', 'Male', 'Middle Aged', 'Palliative Care', 'Patient Satisfaction', 'Program Evaluation', 'Quality of Life', 'Respite Care', 'United Kingdom'] | 15,690,870 | [['M01.060.116'], ['M01.060.116.100'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['E02.760.246', 'N02.421.585.246'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['E02.760.611.470', 'N02.421.143.524.470', 'N02.421.533.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Verotoxin A subunit protects lymphocytes and T cell lines against X4 HIV infection in vitro. | Our previous genetic, pharmacological and analogue protection studies identified the glycosphingolipid, Gb(3) (globotriaosylceramide, Pk blood group antigen) as a natural resistance factor for HIV infection. Gb(3) is a B cell marker (CD77), but a fraction of activated peripheral blood mononuclear cells (PBMCs) can also... | ['Cell Proliferation', 'Cell Survival', 'Cells, Cultured', 'Gene Expression Profiling', 'HIV Infections', 'HIV-1', 'Humans', 'Jurkat Cells', 'Leukocytes, Mononuclear', 'Oligonucleotide Array Sequence Analysis', 'Protein Subunits', 'Shiga Toxin 1', 'Shiga Toxin 2', 'T-Lymphocytes'] | 23,242,319 | [['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['A11.251'], ['E05.393.332'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.495', 'A11.2... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reversible plasma and red blood cells volumes increases in acromegaly. | Plasma volume (PV) and red blood cells volume (RBCV) were measured in 76 normotensive acromegalic patients (42 males and 34 females) and compared with those of 28 controls on the basis of body surface. In untreated males PV and RBCV were significantly higher than in normals (P less than 0.001) and total blood volume (T... | ['Acromegaly', 'Adult', 'Aged', 'Erythrocytes', 'Female', 'Growth Hormone', 'Hematocrit', 'Humans', 'Male', 'Middle Aged', 'Plasma Volume'] | 577,334 | [['C05.116.132.082', 'C10.228.140.617.738.250.100', 'C19.700.355.179'], ['M01.060.116'], ['M01.060.116.100'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['E01.370.225.625.400', 'E05.200.625.400', 'G09.188.370.374'], ['B01.050.150.900.649.313.988.400.112.40... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin. | The Escherichia coli SMC complex, MukBEF, acts in chromosome segregation. MukBEF shares the distinctive architecture of other SMC complexes, with one prominent difference; unlike other kleisins, MukF forms dimers through its N-terminal domain. We show that a 4-helix bundle adjacent to the MukF dimerisation domain inter... | ['Chromosomal Proteins, Non-Histone', 'Escherichia coli', 'Escherichia coli Proteins', 'Gene Expression Regulation, Bacterial', 'Protein Binding', 'Protein Domains', 'Protein Interaction Mapping', 'Protein Multimerization'] | 29,323,635 | [['D12.776.660.235', 'D12.776.664.235'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['G05.308.300'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709.275.750', 'G02.111.570.820.709.610.500'], ['E05.601.690'], ['G02.111.694']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Streptococcus sinensis sp. nov., a novel species isolated from a patient with infective endocarditis. | A bacterium was isolated from the blood culture of a patient with infective endocarditis. The cells were facultative anaerobic, nonsporulating, gram-positive cocci arranged in chains. The bacterium grows on sheep blood agar as alpha-hemolytic, gray colonies of 0.5 to 1 mm in diameter after 24 h of incubation at 37 degr... | ['Adult', 'Base Sequence', 'Endocarditis, Bacterial', 'Female', 'Humans', 'Molecular Sequence Data', 'Phenotype', 'Phylogeny', 'Prospective Studies', 'RNA, Ribosomal, 16S', 'Streptococcus'] | 11,880,397 | [['M01.060.116'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C01.150.252.245', 'C01.190.249', 'C14.260.249', 'C14.280.282.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G05.695'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.318.372.500.750.625', 'N05.715.360.330.50... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Nanomolar concentrations of prostaglandin E1 induce changes in the surface organization of high-density lipoproteins. | Incubation of high-density lipoproteins (HDL) with small amounts of the prostaglandin E1 (PGE1) results in mobilization of the spin-label 5-doxylstearic acid incorporated into the HDL surface monolayer as well as in decreased binding of apoprotein A1 antibodies to the HDL surface. These effects are manifested at striki... | ['Alprostadil', 'Apolipoprotein A-I', 'Cyclic N-Oxides', 'Dose-Response Relationship, Drug', 'Electron Spin Resonance Spectroscopy', 'Humans', 'Lipoproteins, HDL', 'Spin Labels', 'Surface Properties', 'Ultracentrifugation'] | 8,387,742 | [['D10.251.355.255.550.250.100', 'D10.251.355.325.050', 'D23.469.050.175.725.250.100'], ['D10.532.091.200.100', 'D12.776.070.400.200.100', 'D12.776.521.120.200.100'], ['D03.661.243'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.196.867.519.274'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.532.432', 'D12.7... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
ADP-ribosylating and glucosylating toxins as tools to study secretion in RBL cells. | The influence of different ADP-ribosylating and glucosylating cytotoxins on stimulated protein tyrosine phosphorylation and secretion in rat basophilic leukemia (RBL) cells was studied. Treatment of RBL cells with Clostridium botulinum C2 toxin, which specifically ADP-ribosylated monomeric G-actin and caused complete d... | ['ADP Ribose Transferases', 'Adenosine Diphosphate Ribose', 'Animals', 'Bacterial Proteins', 'Bacterial Toxins', 'Basophils', 'Botulinum Toxins', 'Clostridioides difficile', 'Glycosylation', 'Leukemia, Basophilic, Acute', 'Phosphorylation', 'Poly(ADP-ribose) Polymerases', 'Rats', 'Serotonin', 'Tumor Cells, Cultured'] | 9,193,676 | [['D08.811.913.400.725.115'], ['D03.633.100.759.646.138.124.070.125', 'D09.408.620.569.070.125', 'D13.695.667.138.124.070.125', 'D13.695.827.068.124.070.125', 'D13.695.827.708.070.125'], ['B01.050'], ['D12.776.097'], ['D23.946.123'], ['A11.118.637.415.120', 'A11.627.340.120', 'A15.145.229.637.415.120', 'A15.382.490.315... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of physical training on the lung growth of infant rats. | The effect of swimming exercise on the growth of the lungs was examined in 60 Charles River Outbred Albino male rats during their second and third months of life. A tw0-by-three factorial analysis of variance design was used for significant differences due to duration of exercise (swimming 5 minutes per day 5 days per ... | ['Animals', 'Blood Volume', 'Body Weight', 'Lung', 'Lung Volume Measurements', 'Male', 'Organ Size', 'Physical Exertion', 'Pulmonary Alveoli', 'Rats', 'Swimming', 'Time Factors'] | 1,011,959 | [['B01.050'], ['G09.188.130', 'G09.330.380.092'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['A04.411'], ['E01.370.386.700.485'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['G11.427.683'], ['A04.411.71... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
A Pilot Stability Study of Dehydroepiandrosterone Rapid-dissolving Tablets Prepared by Extemporaneous Compounding. | Dehydroepiandrosterone supplementation is used to treat a variety of conditions. Rapid-dissolving tablets are a relatively novel choice for compounded dehydroepiandrosterone dosage forms. While rapid-dissolving tablets offer ease of administration, there are uncertainties about the physical and chemical stability of th... | ['Chromatography, High Pressure Liquid', 'Dehydroepiandrosterone', 'Drug Compounding', 'Drug Stability', 'Drug Storage', 'Humidity', 'Kinetics', 'Pilot Projects', 'Solubility', 'Steroids', 'Tablets', 'Temperature', 'Time Factors', 'Water'] | 28,346,201 | [['E05.196.181.400.300'], ['D04.210.500.054.079.429.625', 'D04.210.500.578.502.400', 'D06.472.040.502.400', 'D06.472.334.851.968.952'], ['E05.916.270'], ['E05.916.330'], ['E05.916.350'], ['G16.500.275.063.725.310', 'G16.500.750.775.310', 'N06.230.150.372', 'N06.230.300.100.725.310'], ['G01.374.661', 'G02.111.490'], ['E... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Acute segmental testicular infarction. | We report a case of segmental testicular infarction occurring in a patient with sickle cell trait. A 20-year-old African American man presented with a complaint of sudden onset, acute severe left testicular pain for 24 hours. Scrotal ultrasound revealed a hypo-echoic mass in the left testicle. The hypo-echoic area demo... | ['Acute Disease', 'Adult', 'Humans', 'Male', 'Necrosis', 'Testicular Diseases', 'Ultrasonography'] | 16,771,749 | [['C23.550.291.125'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.717'], ['C12.294.829', 'C19.391.829'], ['E01.370.350.850']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
High frequency of concomitant mastocytosis in patients with acute myeloid leukemia exhibiting the transforming KIT mutation D816V. | The KIT mutation D816V is associated with autonomous growth of mast cells (MC) and is detectable in most patients with systemic mastocytosis (SM), including cases with associated hematologic non-MC-lineage disease (AHNMD). Recently, KIT D816V was reported to be expressed in patients with acute myeloid leukemia (AML). H... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Leukemia, Myeloid, Acute', 'Male', 'Mast Cells', 'Mastocytosis, Systemic', 'Middle Aged', 'Mutation', 'Polymorphism, Restriction Fragment Length', 'Proto-Oncogene Proteins c-kit', 'Retrospective Studies', 'Sensitivity and... | 20,471,335 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['C04.557.337.539.275'], ['A11.329.427', 'A15.382.652'], ['C04.557.450.565.465.750', 'C20.543.520.350.750'], ['... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Self-medication in smoking cessation among smokers]. | INTRODUCTION: According to the World Health Organization defines self-medication by using OTC (over-the-counter) to treatment diseases or symptoms recognized by yourself without pay a visit to the doctor's office. Increasing availability of OTC medicines cause that Poles are more and more willing to take self-medicatio... | ['Adult', 'Female', 'Humans', 'Male', 'Middle Aged', 'Poland', 'Self Medication', 'Smoking Cessation', 'Surveys and Questionnaires', 'Tobacco Use Cessation Devices', 'Treatment Outcome'] | 26,946,559 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.542.248.679'], ['E02.319.900', 'E02.900.900'], ['F01.145.488.732'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['E02.980'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Severe sepsis and septic shock due to Plasmodium vivax infection. | Plasmodium vivax malaria is typically characterized by a mild and benign clinical course. Organ dysfunction is rarely seen, whereas acute lung injury has been found to occur after starting antimalarial treatment. We present an unusual case of severe sepsis and septic shock due to Plasmodium vivax monoinfection. | ['Adult', 'Humans', 'Malaria, Vivax', 'Male', 'Sepsis', 'Shock, Septic'] | 23,380,095 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.752.530.700', 'C01.920.875.700'], ['C01.757', 'C23.550.470.790.500'], ['C01.757.800', 'C23.550.470.790.500.800', 'C23.550.835.900.712']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effectiveness of a new multibending scope for endoscopic mucosal resection. | BACKGROUND AND STUDY AIMS: Each year at our institution we have been performing over 100 endoscopic mucosal resections (EMRs) for gastric tumor. However, there are some tumor locations where it is difficult to carry out this procedure, such as the lesser curvature or posterior wall of the gastric body, the cardia, and ... | ['Adenoma', 'Aged', 'Aged, 80 and over', 'Endoscopes, Gastrointestinal', 'Female', 'Gastric Mucosa', 'Gastroscopy', 'Humans', 'Male', 'Middle Aged', 'Stomach Neoplasms'] | 15,057,677 | [['C04.557.470.035'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.230.220.260', 'E07.858.240.260'], ['A03.556.875.875.440', 'A10.615.550.291'], ['E01.370.372.250.250.325', 'E01.370.388.250.250.250.320', 'E04.210.240.250.320', 'E04.502.250.250.250.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction. | In the present paper, we examined the effects of a natural cyclopeptide RA-V on human breast cancer cells and the underlying mechanisms. RA-V significantly inhibited the growth of human breast cancer MCF-7, MDA-MB-231 cells and murine breast cancer 4T1 cells. In addition, RA-V triggered mitochondrial apoptotic pathway ... | ['Animals', 'Antineoplastic Agents, Phytogenic', 'Apoptosis', 'Breast Neoplasms', 'Cell Line, Tumor', 'Female', 'Humans', 'Mice', 'Mitochondria', 'Peptides, Cyclic', 'Plant Extracts', 'Protein Interaction Mapping', 'Protein-Serine-Threonine Kinases', 'Proto-Oncogene Proteins c-akt', 'Pyruvate Dehydrogenase Acetyl-Trans... | 23,274,515 | [['B01.050'], ['D27.505.954.248.179'], ['G04.146.954.035'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['D04.345.566', 'D12.644.641'], ['D20.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The vibrational spectra of [15N2]-succinonitrile. | For the first time, the infrared and Raman spectra of [15N2]-succinonitrile are presented and discussed in detail. Assignments of the vibrational bands of its two rotational conformers gauche and trans, respectively, have been made for both infrared and Raman spectra. The assignments were based on a recent ab-initio fo... | ['Nitriles', 'Nitrogen Isotopes', 'Spectrophotometry, Infrared', 'Spectrum Analysis, Raman', 'Vibration'] | 11,471,715 | [['D02.626'], ['D01.268.604.500', 'D01.362.625.500', 'D01.496.586'], ['E05.196.712.726.676', 'E05.196.867.826.676'], ['E05.196.822.860', 'E05.196.867.890'], ['G01.374.930']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fatigue in Emergency Services Operations: Assessment of the Optimal Objective and Subjective Measures Using a Simulated Wildfire Deployment. | Under controlled laboratory conditions, neurobehavioral assays such as the Psychomotor Vigilance Task (PVT) are sensitive to increasing levels of fatigue, and in general, tend to correlate with subjective ratings. However, laboratory studies specifically curtail physical activity, potentially limiting the applicability... | ['Adult', 'Australia', 'Diagnostic Self Evaluation', 'Fatigue', 'Female', 'Firefighters', 'Fires', 'Hot Temperature', 'Humans', 'Male', 'Middle Aged', 'Occupational Diseases', 'Occupational Exposure', 'Sleep Deprivation'] | 26,840,323 | [['M01.060.116'], ['Z01.639.100', 'Z01.678.100.373'], ['E01.370.360', 'F01.752.747.792.220'], ['C23.888.369'], ['M01.526.373.400'], ['N06.230.216'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Migraines and other headaches: an approach to diagnosis and classification. | Headache is a symptom that accounts for over 18 million visits to physicians each year. In an effort to resolve inconsistencies and problems with the differentiation of specific types of headache, the International Headache Society (IHS) has established a classification system. For each major type of headache, the IHS ... | ['Headache', 'Humans', 'Magnetic Resonance Imaging', 'Migraine Disorders', 'Physical Examination', 'Tomography, X-Ray Computed'] | 7,732,951 | [['C23.888.592.612.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['C10.228.140.546.399.750'], ['E01.370.600'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Autoimmune diseases in adults with atopic dermatitis. | BACKGROUND: An increased susceptibility to autoimmune disease has been shown in patients with atopic dermatitis (AD), but data remain scarce and inconsistent.OBJECTIVE: We examined the co-occurrence of selected autoimmune diseases in adult patients with AD.METHODS: Nationwide health registers were used. Adult patients ... | ['Adult', 'Autoimmune Diseases', 'Dermatitis, Atopic', 'Female', 'Humans', 'Male'] | 27,742,171 | [['M01.060.116'], ['C20.111'], ['C16.320.850.210', 'C17.800.174.193', 'C17.800.815.193', 'C17.800.827.210', 'C20.543.480.343'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Tryptophan metabolism and urinary quinoline bases in the greyhound. | Three quinoline bases may be found in greyhound urine. 2-aminomethylquinoline is excreted in fresh urine and two others, quinaldine and 2-hydroxymethylquinoline, are formed as the urine decays. Radiolabelling was employed to demonstrate that these bases are derived from the amino acid tryptophan. | ['Animals', 'Chromatography, Thin Layer', 'Dogs', 'Female', 'Hydroxyquinolines', 'Male', 'Quinaldines', 'Quinolines', 'Tryptophan'] | 3,775,119 | [['B01.050'], ['E05.196.181.400.537'], ['B01.050.150.900.649.313.750.250.216.200'], ['D03.633.100.810.350'], ['D03.633.100.810.637'], ['D03.633.100.810'], ['D12.125.072.050.850', 'D12.125.142.875']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Expression regulation of the protelomerase gene of the bacteriophage N15]. | The N15 bacteriophage, when in the lysogenic state, does not integrate into the chromosome; in fact, it exists as a linear plasmid with the covalently closed ends. Upon infection, the phage DNA circularizes via its cohesive ends, after which a specific enzyme, the N15 protelomerase, cuts the circular molecule thus gene... | ['Bacteriophages', 'Base Sequence', 'Enzyme Precursors', 'Gene Expression Regulation, Viral', 'Molecular Sequence Data', 'Promoter Regions, Genetic', 'Telomerase', 'Viral Proteins', 'Virus Replication'] | 15,164,718 | [['B04.123'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.622', 'D12.776.811.243'], ['G05.308.385'], ['L01.453.245.667'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D08.811.913.696.445.308.300.750.750', 'D12.776.157.687.613', 'D12.776.157.725.500.921', ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease. | Heparan sulfate (HS) is a structurally complex polysaccharide that interacts with a broad spectrum of extracellular effector ligands and thereby is thought to regulate a diverse array of biologic processes. The specificity of HS-ligand interactions is determined by the arrangement of sulfate groups on HS, which creates... | ['Amyloidogenic Proteins', 'Amyloidosis', 'Animals', 'Antibodies, Monoclonal', 'Biomarkers', 'CHO Cells', 'Carbohydrate Sequence', 'Cell Proliferation', 'Cricetinae', 'Cricetulus', 'Disease Models, Animal', 'Endothelial Cells', 'Female', 'Heparitin Sulfate', 'Humans', 'Male', 'Mice', 'Neoplasms', 'Rats', 'Rats, Wistar'... | 20,837,479 | [['D12.776.049.407'], ['C18.452.845.500'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.101'], ['A11.251.210.200', 'A11.436.155'], ['G02.111.570.160', 'L01.453.245.667.160'], ['G04.161.750', 'G07.345.249.410.750'], ['B01.050.150.900.649.313.992.635.07... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of the veterinary ionophore monensin on the structure and activity of a tropical soil bacterial community. | Monensin (MON) is a coccidiostat used as a growth promoter that can reach the environment through fertilization with manure from farm animals. To verify whether field-relevant concentrations of this drug negatively influence the structure and activity of tropical soil bacteria, plate counts, CO2 efflux measurements, ph... | ['Bacteria', 'Carbon Dioxide', 'Costa Rica', 'Dose-Response Relationship, Drug', 'Fatty Acids', 'Ionophores', 'Microbial Consortia', 'Monensin', 'Phospholipids', 'Soil Microbiology', 'Soil Pollutants', 'Veterinary Drugs'] | 31,588,829 | [['B03'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['Z01.107.169.238'], ['G07.690.773.875', 'G07.690.936.500'], ['D10.251'], ['D27.505.519.562.374', 'D27.720.395'], ['G06.591.750', 'G16.500.275.157.049.100.500.750', 'N06.230.124.049.100.500.500'], ['D03.383.312.600'], ['D10.570.755'], ['H01.158.273.540.274.55... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Necrotizing tracheobronchitis: a complication of high frequency jet ventilation. | The tracheal and bronchial lesions observed are described in seven patients, presenting with respiratory distress syndrome and receiving both conventional and high frequency jet ventilation for various periods. The histological findings are related to the duration of the exposure as well as the number of pulsations adm... | ['Adolescent', 'Adult', 'Bronchitis', 'Female', 'High-Frequency Jet Ventilation', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Middle Aged', 'Respiratory Distress Syndrome, Newborn', 'Tracheitis'] | 3,135,663 | [['M01.060.057'], ['M01.060.116'], ['C01.748.099', 'C08.127.446', 'C08.381.495.146', 'C08.730.099'], ['E02.041.625.508.510', 'E02.880.820.508.510'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['M01.060.116.630'], ['C08.381.840.500', 'C08.618.840.500', 'C16.614.521.563'], ['C0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Connexin 43 expression on peripheral blood eosinophils: role of gap junctions in transendothelial migration. | Eosinophils circulate in the blood and are recruited in tissues during allergic inflammation. Gap junctions mediate direct communication between adjacent cells and may represent a new way of communication between immune cells distinct from communication through cytokines and chemokines. We characterized the expression ... | ['Cell Line', 'Cell Separation', 'Coloring Agents', 'Connexin 43', 'Endothelial Cells', 'Eosinophils', 'Fluoresceins', 'Gap Junctions', 'Humans', 'Microscopy, Confocal', 'Microvessels', 'Transendothelial and Transepithelial Migration'] | 25,110,696 | [['A11.251.210'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['D27.720.233'], ['D12.776.543.585.250.200'], ['A11.436.275'], ['A11.118.637.415.345', 'A11.627.340.345', 'A15.145.229.637.415.345', 'A15.382.490.315.251'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['A11.284.149.165.420.4... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Diagnosis of sympathetically maintained pain in posttraumatic complex regional pain syndrome with laser Doppler flowmetry]. | Forty-nine patients with posttraumatic complex regional pain syndrome (CRPS) of the upper extremities were investigated by laser Doppler flowmetry (LDF) with wavelet-analysis of skin blood flow oscillations. Clinical evaluation of sympathetically maintained pain was carried out after the thoracoscopic clipping above an... | ['Aged', 'Complex Regional Pain Syndromes', 'Female', 'Hand', 'Humans', 'Laser-Doppler Flowmetry', 'Male', 'Middle Aged', 'Radius Fractures', 'Regional Blood Flow', 'Sympathetic Nervous System', 'Wavelet Analysis'] | 22,677,665 | [['M01.060.116.100'], ['C10.177.195', 'C10.668.829.250'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.370.475', 'E05.830.500'], ['M01.060.116.630'], ['C26.088.268.556', 'C26.404.562'], ['G09.330.100.780'], ['A08.800.050.800'], ['E05.959', 'G17.915', 'L01.224.800.750']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Cyanosis and Stroke due to Functional Cor Triatriatum Dexter in a Neonate. | Small remnants of the right valve of the sinus venosus are commonly found in adults, but the incidence and risk associated with these embryonic remnants in neonates are not well studied. The following report describes a cyanotic neonate with a large Eustachian valve remnant creating a functional cor triatriatum dexter ... | ['Cardiac Surgical Procedures', 'Cor Triatriatum', 'Cyanosis', 'Diagnosis, Differential', 'Echocardiography', 'Female', 'Humans', 'Infant, Newborn', 'Magnetic Resonance Imaging', 'Stroke'] | 29,316,539 | [['E04.100.376', 'E04.928.220'], ['C14.240.400.200', 'C14.280.400.200', 'C16.131.240.400.200'], ['C23.888.248'], ['E01.171'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E01.370.350.825.500'], ['C10.228.140.300.775', 'C14... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The stress-related hormone norepinephrine induced upregulation of Nix, contributing to ECM protein expression. | Organ fibrosis has been viewed as a major medical problem that leads to progressive dysfunction of the organ and eventually the death of patients. Stress-related hormone norepinephrine (NE) has been reported to exert fibrogenic actions in the injured organ. Nix plays a critical role in pressure overload-induced cardiac... | ['Adrenergic Agonists', 'Adrenergic Antagonists', 'Animals', 'Cell Proliferation', 'Collagen', 'Dose-Response Relationship, Drug', 'Extracellular Matrix', 'Fibroblasts', 'Fibronectins', 'Fibrosis', 'Membrane Proteins', 'Mice', 'Mitochondrial Proteins', 'NIH 3T3 Cells', 'Norepinephrine', 'Protein Kinase C', 'Protein Kin... | 24,803,315 | [['D27.505.519.625.050.100', 'D27.505.696.577.050.100'], ['D27.505.519.625.050.200', 'D27.505.696.577.050.200'], ['B01.050'], ['G04.161.750', 'G07.345.249.410.750'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.284.295.310'], ['A11.329.228'], ['D12.776.377.715.390', 'D12.776... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Navigated Iso-C(3D)-based drilling of a osteochondral lesion of the talus]. | Retrograde drilling of osteochondral lesions has obtained acceptable results in the initial stage. Intraoperatively not all lesions are accessible with the arthroscopic technique, despite being readily identifiable with modern imaging preoperatively. As an alternative, open surgical treatment is recommended to achieve ... | ['Adult', 'Equipment Design', 'Fluoroscopy', 'Humans', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Magnetic Resonance Imaging', 'Male', 'Mathematical Computing', 'Osteochondritis', 'Postoperative Complications', 'Reproducibility of Results', 'Surgery, Computer-Assisted', 'Surgical Instruments'... | 14,634,741 | [['M01.060.116'], ['E05.320'], ['E01.370.350.700.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.400', 'L01.224.308.410'], ['E01.370.350.825.500'], ['L01.224.680'], ['C05.116.791', 'C05.182.520', 'C17.300.182.520'], ['C23.550.767'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
MAP1B related syndrome: Case presentation and review of literature. | The microtubule-associated protein 1B (MAP1B) gene serves an important role in axonal growth and brain development. Its expression is known to be elevated in regions that retain high brain plasticity and is regulated by the fragile X mental retardation protein. MAP1B mutations have recently been associated with a pheno... | ['Axons', 'Brain', 'Codon, Nonsense', 'Developmental Disabilities', 'Exome', 'Female', 'Fragile X Mental Retardation Protein', 'Gene Expression Regulation, Developmental', 'Genetic Predisposition to Disease', 'Humans', 'Infant', 'Infant, Newborn', 'Intellectual Disability', 'Microtubule-Associated Proteins', 'Pregnancy... | 31,317,654 | [['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A08.186.211'], ['D13.444.735.544.355.250.235', 'G05.360.335.355.250.235', 'G05.365.590.195'], ['F03.625.421'], ['G05.360.340.011'], ['D12.776.157.725.061', 'D12.776.631.299', 'D12.776.664.962.124'], ['G05.308.310'], ['C23.550.291.687.500', 'G0... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A new generation of tools for search, recovery and quality evaluation of World Wide Web medical resources. | Although the Internet is already a valuable information resource in medicine, there are important challenges to be faced before physicians and general users will have extensive access to this information. As a result of a research effort to compile a health-related Internet directory, new tools and strategies have been... | ['Documentation', 'Evaluation Studies as Topic', 'Information Storage and Retrieval', 'Internet', 'Software', 'User-Computer Interface'] | 11,142,063 | [['L01.453.245'], ['E05.337', 'N05.715.360.335'], ['L01.313.500.750.280', 'L01.470'], ['L01.224.230.110.500'], ['L01.224.900'], ['L01.224.900.910']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Sarcopenia in Ovarian Cancer Patients, Oncologic Outcomes Revealing the Importance of Clinical Nutrition: Review of Literature. | INTRODUCTION: Ovarian cancer is the leading cause of death among gynecological malignancies. Its usual clinical manifestation is at advanced stages, with nutritional impairment, weight loss, and a consequent decline in skeletal muscle mass and strength (defined as sarcopenia). The relationship between sarcopenia and de... | ['Female', 'Humans', 'Muscle, Skeletal', 'Ovarian Neoplasms', 'Sarcopenia'] | 31,333,115 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.567', 'A10.690.552.500'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'], ['C10.597.613.612.500', 'C23.300.070.500.500', 'C23.888.592.608.612.500']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Predictors of mortality in surgical patients with Acinetobacter baumannii bacteremia. | BACKGROUND: Acinetobacter baumannii has emerged as an important pathogen of nosocomial infection. The aim of this study was to evaluate the predictors of poor outcome in surgical patients with A baumannii bacteremia.METHODS: We retrospectively recruited a total of 50 patients who developed A baumannii bacteremia within... | ['Acinetobacter Infections', 'Acinetobacter baumannii', 'Adult', 'Aged', 'Aged, 80 and over', 'Bacteremia', 'Cross Infection', 'Female', 'Humans', 'Male', 'Microbial Sensitivity Tests', 'Middle Aged', 'Retrospective Studies', 'Treatment Outcome'] | 21,524,616 | [['C01.150.252.400.560.022'], ['B03.440.400.425.537.050.099', 'B03.660.250.530.050.099'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['C01.248', 'C23.550.291.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.5... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Surgical Treatment as a First Option of the Lower Eyelid Xanthelasma. | Xanthelasma palpebrarum represents yellowish plaques, which mostly appear near the inner cantus of the eyelid. In most patients, cosmetic reasons are the main purpose for their removal.The author presents a patient with a lower eyelid xanthelasma where surgical excision was used as a first treatment option. Cosmetic re... | ['Eyelid Diseases', 'Female', 'Humans', 'Middle Aged', 'Xanthomatosis'] | 28,857,993 | [['C11.338'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C18.452.584.750']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Squamous cell carcinoma of penis presenting as groin metastasis 3 years before the primary. | A 78-year-old patient who developed bilateral inguinal node metastatic squamous cell carcinoma, more than 3 years before the primary penile carcinoma declared itself, is presented. An exhaustive multispeciality search for the primary including a circumcision proved fruitless. A review of the relevant literature is summ... | ['Aged', 'Carcinoma, Squamous Cell', 'Humans', 'Inguinal Canal', 'Lymphatic Metastasis', 'Male', 'Neoplasms, Unknown Primary', 'Penile Neoplasms'] | 16,631,563 | [['M01.060.116.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.923.047.412'], ['C04.697.650.560', 'C23.550.727.650.560'], ['C04.697.650.895', 'C23.550.727.650.895'], ['C04.588.945.440.715', 'C12.294.260.500', 'C12.294.494.591', 'C12.758.409.500']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Role of spirituality in patients with sickle cell disease. | BACKGROUND: Patients with sickle cell disease cope with their disease in various ways, such as psychological counseling, hypnosis, medication, and prayer. Spirituality is a coping mechanism in a variety of diseases. This study evaluates the role of spirituality in patients coping with the pain of sickle cell disease.ME... | ['Adaptation, Psychological', 'Adult', 'Anemia, Sickle Cell', 'Cross-Sectional Studies', 'Female', 'Georgia', 'Holistic Health', 'Humans', 'Male', 'Middle Aged', 'Pain', 'Regression Analysis', 'Religion', 'Surveys and Questionnaires'] | 11,314,918 | [['F01.058'], ['M01.060.116'], ['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['Z01.107.567.875.075.250', 'Z01.107.567.875.750.370'], ['E02.190.321', 'K01.752.667.710', 'N01.400.350'], ['B01.050.150.900... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Is the precautionary principle used to cover up ignorance? | The precautionary principle is rapidly spreading in risk management in spite of vague understanding of its consequences. Some caveats are presented in this commentary, and some principles proposed for improved risk assessment/risk management procedures. Improvement is especially needed in such cases where the risks of ... | ['Administrative Personnel', 'Animals', 'Forecasting', 'Humans', 'International Agencies', 'Research Support as Topic', 'Risk Assessment', 'Risk Management'] | 15,379,779 | [['M01.526.070'], ['B01.050'], ['I01.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.540.514'], ['N03.219.483.645'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['N03.219.463.800', 'N04.452.871']] | ['Named Groups [M]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Unilateral cortical dysplasia associated with contralateral hyperplasia of the brainstem. | Magnetic resonance imaging of a patient with unilateral frontotemporal cortical dysplasia is described. The brainstem showed ipsilateral hypoplasia, a usual but subjective radiological finding reportedly associated with unilateral cortical dysplasias, which inherently may cause underestimation of contralateral brainste... | ['Adolescent', 'Brain Stem', 'Cerebral Cortex', 'Humans', 'Hyperplasia', 'Magnetic Resonance Imaging', 'Male'] | 7,491,194 | [['M01.060.057'], ['A08.186.211.132'], ['A08.186.211.200.885.287.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.444'], ['E01.370.350.825.500']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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