Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Lesson of the month 2: A case of nitrous oxide-induced pancytopenia. | An 18-year-old female patient presented to the emergency department with non-specific neurological and gastrointestinal symptoms and was found to be pancytopenic. Her vitamin B12 level was low with a normal mean corpuscular volume and her full blood count 2 months previously had been within normal range. She reported h... | ['Adolescent', 'Female', 'Humans', 'Hydroxocobalamin', 'Nitrous Oxide', 'Pancytopenia', 'Vitamin B 12 Deficiency'] | 30,872,294 | [['M01.060.057'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.578.840.437.777.560', 'D03.633.400.909.437.777.560', 'D04.345.783.437.777.560'], ['D01.362.635.625', 'D01.625.550.550', 'D01.650.550.587.650'], ['C15.378.700'], ['C18.654.521.500.133.699.923']] | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Endocrine changes in maturing primary queens of Zootermopsis angusticollis. | Termite queens are highly specialized for reproduction, but little is known about the endocrine mechanisms regulating this ability. We studied changes in the endocrinology and ovarian maturation in primary reproductive females of the dampwood termite Zootermopsis angusticollis following their release from inhibitory st... | ['Animals', 'Corpora Allata', 'Ecdysteroids', 'Endocrine System', 'Female', 'Hemolymph', 'Isoptera', 'Juvenile Hormones', 'Male', 'Ovary', 'Sex Characteristics', 'Sexual Behavior, Animal'] | 16,081,092 | [['B01.050'], ['A08.713.100', 'A13.250'], ['D04.210.500.247.222.265.165', 'D04.210.500.247.808.756.143', 'D06.472.445.573.271', 'D10.570.938.795.143', 'D23.704.500.143'], ['A06'], ['A13.453'], ['B01.050.500.131.617.485'], ['D06.472.445.573.666'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['G08.686.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The age of alcohol onset and alcohol, cigarette, and marijuana use patterns: an analysis of drug use progression of young adults in New York State. | The authors extend the gateway theory by examining the relationship between the onset age of alcohol and the progression of drug use (alcohol, cigarettes, and marijuana) among 16 to 24 year old young adults residing in New York State. Logit analysis is employed to estimate the impact of the early onset of alcohol use o... | ['Adolescent', 'Adult', 'Age Factors', 'Alcohol Drinking', 'Cannabis', 'Child', 'Female', 'Humans', 'Logistic Models', 'Male', 'New York', 'Nicotine', 'Sex Factors', 'Substance-Related Disorders', 'Surveys and Questionnaires', 'United States'] | 1,446,964 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.145.317.269'], ['B01.650.940.800.575.912.250.859.937.055.500'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances. | The 5' and 3' termini of RNA play important roles in many cellular processes. Using F?rster resonance energy transfer (FRET), we show that mRNAs and lncRNAs have an intrinsic propensity to fold in the absence of proteins into structures in which the 5' end and 3' end are ?7 nm apart irrespective of mRNA length. Computa... | ['Algorithms', 'Base Sequence', 'Fluorescence Resonance Energy Transfer', 'Humans', 'Nucleic Acid Conformation', 'RNA, Long Noncoding', 'RNA, Messenger'] | 30,337,527 | [['G17.035', 'L01.224.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.712.516.600.676.500', 'G01.154.240.280', 'G02.111.255.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.444.735.790.375'], ['D13.444.735.544']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives. | A series of novel oligorhamnoside derivatives (1-10) and naturally occurring cleistrioside-5 were synthesized and evaluated for their in vitro antibacterial activities. Among them, dirhamnoside derivative 7 and cleistrioside-5 displayed similar antibacterial profiles and exhibited moderate to good inhibitory activities... | ['Anti-Bacterial Agents', 'Bacteria', 'Glycosides', 'Microbial Sensitivity Tests'] | 21,864,832 | [['D27.505.954.122.085'], ['B03'], ['D09.408'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantification of arterial flow using digital subtraction angiography. | PURPOSE: In this paper, a method for the estimation of arterial hemodynamic flow from x-ray video densitometry data is proposed and validated using an in vitro setup.METHODS: The method is based on the acquisition of three-dimensional rotational angiography and digital subtraction angiography sequences. A modest contra... | ['Angiography, Digital Subtraction', 'Arteries', 'Carotid Arteries', 'Cerebral Arteries', 'Hemodynamics', 'Humans', 'Phantoms, Imaging'] | 23,039,662 | [['E01.370.350.600.350.700.060', 'E01.370.350.700.060.060', 'E01.370.350.700.700.060', 'E01.370.350.760.060', 'E01.370.370.050.060'], ['A07.015.114'], ['A07.015.114.186'], ['A07.015.114.228'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.671']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Distinct Kv channel subtypes contribute to differences in spike signaling properties in the axon initial segment and presynaptic boutons of cerebellar interneurons. | The discrete arrangement of voltage-gated K(+) (Kv) channels in axons may impart functional advantages in action potential (AP) signaling yet, in compact cell types, the organization of Kv channels is poorly understood. We find that in cerebellar stellate cell interneurons of mice, the composition and influence of Kv c... | ['Animals', 'Axons', 'Cerebellum', 'Electrophysiological Phenomena', 'Female', 'Fluorescent Dyes', 'Immunohistochemistry', 'Interneurons', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Microscopy, Fluorescence', 'Patch-Clamp Techniques', 'Potassium Channels', 'Presynaptic Terminals', 'Receptors, AMPA', 'Receptors, GABA-A', 'R... | 24,806,686 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A08.186.211.132.810.428.200'], ['G07.265'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.5... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Risk factors for colonization with extended-spectrum beta-lactamase-producing bacteria and intensive care unit admission. | Extended-spectrum beta-lactamase (ESBL)-producing bacteria are emerging pathogens. To analyze risk factors for colonization with ESBL-producing bacteria at intensive care unit (ICU) admission, we conducted a prospective study of a 3.5-year cohort of patients admitted to medical and surgical ICUs at the University of Ma... | ['Aged', 'Cohort Studies', 'Cross-Sectional Studies', 'Drug Resistance, Multiple, Bacterial', 'Escherichia coli', 'Escherichia coli Infections', 'Female', 'Humans', 'Intensive Care Units', 'Klebsiella', 'Klebsiella Infections', 'Male', 'Microbial Sensitivity Tests', 'Middle Aged', 'Prospective Studies', 'Risk Factors',... | 17,953,083 | [['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['B03.440.450.425.325.300', 'B03.660.250.1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Etiology of urethral discharge in West Africa: the role of Mycoplasma genitalium and Trichomonas vaginalis. | OBJECTIVE: To determine the etiological role of pathogens other than Neisseria gonorrhoeae and Chlamydia trachomatis in urethral discharge in West African men.METHODS: Urethral swabs were obtained from 659 male patients presenting with urethral discharge in 72 primary health care facilities in seven West African countr... | ['Adult', 'Africa, Western', 'Animals', 'Case-Control Studies', 'Chlamydia trachomatis', 'Humans', 'Logistic Models', 'Mycoplasma', 'Mycoplasma Infections', 'Neisseria gonorrhoeae', 'Polymerase Chain Reaction', 'Prevalence', 'Sexually Transmitted Diseases', 'Statistics, Nonparametric', 'Trichomonas Infections', 'Tricho... | 11,242,818 | [['M01.060.116'], ['Z01.058.290.190'], ['B01.050'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B03.440.190.190.190.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.5... | ['Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
DNA uptake in competent Streptococcus pneumoniae requires ATP and is regulated by cytoplasmic pH. | DNA uptake in competent Streptococcus pneumoniae was strongly dependent on intracellular pH. Ionophore treatments that either acidified or alkalinized the cytoplasm reduced DNA transport. This indicates that the optimum pH for DNA uptake corresponds to the intracellular pH of competent bacteria which is 8.3 +/- 0.2. In... | ['Adenosine Triphosphate', 'Arsenates', 'Biological Transport, Active', 'DNA, Bacterial', 'Hydrogen-Ion Concentration', 'Monensin', 'Nigericin', 'Potassium', 'Sodium', 'Streptococcus pneumoniae', 'Transformation, Bacterial'] | 2,612,880 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D01.075.025', 'D01.248.497.158.050'], ['G03.143.310'], ['D13.444.308.212'], ['G02.300'], ['D03.383.312.600'], ['D03.383.312.634', 'D03.383.663.620'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['D01.268.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fatal Vipera xanthina palestinae envenomation in 16 dogs. | Sixteen fatal dog envenomations by the snake Vipera palaestinae over a 14-y period are described. Most envenomations occurred during the late night hours in the warm months, and 8/16 dogs were bitten on the limbs. The most frequent clinical signs upon admission were soft tissue swelling and edema, local pain, depressio... | ['Animals', 'Dog Diseases', 'Dogs', 'Dyspnea', 'Edema', 'Fatal Outcome', 'Glucocorticoids', 'Hematologic Tests', 'Hemorrhage', 'Pain', 'Retrospective Studies', 'Snake Bites', 'Viperidae'] | 15,487,652 | [['B01.050'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['C08.618.326', 'C23.888.852.371'], ['C23.888.277'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['E01.370.225.625', 'E05.200.625'... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Conformational study of poly(L-lysine) interacting with acidic phospholipid vesicles. | Circular dichroism measurements were carried out on poly(L-lysine) in the presence of vesicles of the negatively charged phospholipids, phosphatidylserine (PS; from bovine brain), phosphatidic acid (PA; prepared from egg yolk lecithin) and dimyristoylphosphatidylglycerol (DMPG). PS vesicles induced a conformational cha... | ['Chemical Phenomena', 'Chemistry, Physical', 'Circular Dichroism', 'Phosphatidic Acids', 'Phosphatidylcholines', 'Phosphatidylglycerols', 'Phosphatidylserines', 'Polylysine', 'Protein Conformation'] | 2,611,343 | [['G02'], ['H01.181.529'], ['E05.196.867.151'], ['D10.570.755.375.760'], ['D10.570.755.375.760.400.800'], ['D10.570.755.375.760.400.885'], ['D10.570.755.375.760.400.971'], ['D12.125.068.555.750', 'D12.125.095.647.750', 'D12.644.760'], ['G02.111.570.820.709']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Transient expression of the angiotensin II receptor: a rapid and functional analysis of a calcium-mobilizing seven-transmembrane domain receptor in COS-7 cells. | The mas oncogene/angiotensin II receptor was subcloned into a mammalian expression vector pCDM8 and used to transiently transfect monkey kidney derived COS-7 cells. As a result, the mas transfected COS-7 cells expressed a functional angiotensin II receptor capable of transducing an increase in intracellular Ca2+ follow... | ['Angiotensin II', 'Animals', 'Calcium', 'Cell Line', 'Cell Membrane', 'Cloning, Molecular', 'Epinephrine', 'Gene Expression', 'Genetic Vectors', 'Haplorhini', 'Kidney', 'Receptors, Angiotensin', 'Transfection'] | 2,514,688 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251.210'], ['A11.284.149'], ['E05.393.220'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A minimalist glutamyl-tRNA synthetase dedicated to aminoacylation of the tRNAAsp QUC anticodon. | Escherichia coli encodes YadB, a protein displaying 34% identity with the catalytic core of glutamyl-tRNA synthetase but lacking the anticodon-binding domain. We show that YadB is a tRNA modifying enzyme that evidently glutamylates the queuosine residue, a modified nucleoside at the wobble position of the tRNA(Asp) QUC... | ['Acylation', 'Anticodon', 'Base Sequence', 'Biological Evolution', 'Conserved Sequence', 'Escherichia coli', 'Glutamate-tRNA Ligase', 'Molecular Mimicry', 'Nucleoside Q', 'Periodic Acid', 'RNA, Bacterial', 'RNA, Transfer, Asp', 'RNA, Transfer, Glu'] | 15,150,343 | [['G02.111.012', 'G02.607.063', 'G03.040'], ['D13.444.735.757.286', 'G05.360.335.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G05.045', 'G16.075'], ['G02.111.570.580'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D08.811.464.263.200.250'], ['G02.111.560', 'G05.545', 'G16.012.750.500... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients. | OBJECTIVE: This study aimed to investigate the potential parameters associated with imaging progression on chest CT from coronavirus disease 19 (COVID-19) patients.RESULTS: The average age of 273 COVID-19 patients enrolled with imaging progression were older than those without imaging progression (p = 0.006). The white... | ['COVID-19', 'Coronavirus Infections', 'Disease Progression', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pandemics', 'Pneumonia, Viral', 'Thorax', 'Tomography, X-Ray Computed'] | 32,275,643 | [['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['C01.925.782.600.550.200'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N06.850.290.200.600'], ['C01.748.610.763', 'C0... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Involvement of toll-like receptor 2 and pro-apoptotic signaling pathways in bone remodeling in osteomyelitis. | BACKGROUND AND AIMS: Osteomyelitis is a common manifestation of invasive Staphylococcus aureus infection characterized by bone loss and destruction. We investigated the role of toll-like receptor 2 (TLR2) in bacterial recognition and clearance in response to infection with an osteomyelitis isolate of S. aureus.METHODS:... | ['Alkaline Phosphatase', 'Animals', 'Apoptosis', 'Bone Remodeling', 'Calcium', 'Cell Differentiation', 'Flow Cytometry', 'Humans', 'JNK Mitogen-Activated Protein Kinases', 'Mice', 'Osteoblasts', 'Osteomyelitis', 'Signal Transduction', 'Staphylococcal Infections', 'Staphylococcus aureus', 'Toll-Like Receptor 2'] | 25,503,704 | [['D08.811.277.352.650.035'], ['B01.050'], ['G04.146.954.035'], ['G11.427.213', 'G16.762.150'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.152'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cyclophosphamide desensitization in patients with severe hypersensitivity reactions to bendamustine. | INTRODUCTION: Cyclophosphamide is a nitrogen mustard alkylator employed in the treatment of many malignancies and autoimmune disorders. Despite reports of cyclophosphamide hypersensitivity ranging from rash to anaphylaxis, no cases of desensitization have been reported in the oncologic setting.CASE REPORT: We report a ... | ['Aged', 'Antineoplastic Agents, Alkylating', 'Bendamustine Hydrochloride', 'Cyclophosphamide', 'Desensitization, Immunologic', 'Drug Hypersensitivity', 'Female', 'Humans', 'Middle Aged', 'Severity of Illness Index'] | 31,433,727 | [['M01.060.116.100'], ['D27.505.519.124.035', 'D27.505.954.248.150', 'D27.888.569.035.035'], ['D02.241.081.114.625', 'D02.455.526.728.650.103', 'D03.633.100.103.123'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['E02.095.465.425.450.310', 'E05.478.610.310'], ['C20.543.206', 'C25.100.468'], ['B01.050.150.90... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Do too many cooks spoil the broth? Multiple physician involvement in medical management of elderly patients and potentially inappropriate drug combinations. | OBJECTIVES: To determine (a) whether the risk of a potentially inappropriate drug combination (PIDC) increases with the number of physicians involved in the medical management of an elderly patient and (b) whether the risk of a PIDC is reduced if a patient has a single primary care physician or a single dispensing phar... | ['Aged', 'Aged, 80 and over', 'Anti-Inflammatory Agents, Non-Steroidal', 'Cardiovascular Agents', 'Community Pharmacy Services', 'Cross-Sectional Studies', 'Drug Interactions', 'Drug Prescriptions', 'Drug Therapy, Combination', 'Family Practice', 'Female', 'Humans', 'Male', 'Odds Ratio', 'Psychotropic Drugs', 'Quebec',... | 8,612,253 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D27.505.954.411'], ['N02.421.143.221', 'N02.421.668.274'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.690.773.968'], ['E02.319.307', 'N02.421.668.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons. | Disruptions in lipid homeostasis have been observed in many neurodevelopmental disorders that are associated with dendrite morphogenesis defects. However, the molecular mechanisms of how lipid homeostasis affects dendrite morphogenesis are unclear. We find that easily shocked (eas), which encodes a kinase with a critic... | ['Animals', 'Calcium', 'Dendrites', 'Drosophila', 'Drosophila Proteins', 'Homeostasis', 'Neurogenesis', 'Phosphatidylethanolamines', 'Phosphotransferases (Alcohol Group Acceptor)', 'Sensory Receptor Cells', 'Sterol Regulatory Element Binding Proteins'] | 29,069,593 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['G07.410'], ['G04.152.912', 'G07.345.500.325.377.687', 'G08.686.784.170.450.500', 'G11.561.620'], ['D10.570.755.375.760.400.8... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Illumination of Arabidopsis roots induces immediate burst of ROS production. | Arabidopsis roots are routinely exposed to light both during their cultivation within transparent Petri dishes and during their confocal microscopy analysis. Here we report that illumination of roots which naturally grow in darkness, even for a few seconds, induces an immediate and strong burst of reactive oxygen speci... | ['Arabidopsis', 'Darkness', 'Light', 'Models, Biological', 'Plant Roots', 'Reactive Oxygen Species', 'Seedlings', 'Staining and Labeling'] | 21,957,498 | [['B01.650.940.800.575.912.250.157.100'], ['G01.590.540.233'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.599.395'], ['A18.400'], ['D01.339.431', 'D01.650.775'], ['A18.550', 'B01.650.819'], ['E01.370.225.500.620.670', 'E01.370.225.750.600.670', 'E05.200.500.620.670', 'E05.200.75... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pontine hypoplasia in Carey-Fineman-Ziter (CFZ) syndrome. | We describe an infant with multiple congenital anomalies including cleft palate and micrognathia, M?bius sequence, developmental delay, myopathy, hydronephrosis, and bilateral clubfeet. These features are consistent with Carey-Fineman-Ziter (CFZ) syndrome (MIM 254940), which has been previously reported in six children... | ['Abnormalities, Multiple', 'Humans', 'Infant, Newborn', 'Magnetic Resonance Imaging', 'Male', 'Pons', 'Syndrome'] | 15,150,780 | [['C16.131.077'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E01.370.350.825.500'], ['A08.186.211.132.810.428.600'], ['C23.550.288.500']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Maternal synchronization of gestational length and lung maturation. | Among all mammals, fetal growth and organ maturation must be precisely synchronized with gestational length to optimize survival at birth. Lack of pulmonary maturation is the major cause of infant mortality in preterm birth. Whether fetal or maternal genotypes influence the close relationship between the length of gest... | ['Animals', 'CCAAT-Enhancer-Binding Proteins', 'Cyclic AMP Response Element-Binding Protein', 'Female', 'Fetal Organ Maturity', 'Genotype', 'Gestational Age', 'Humans', 'Lung', 'Mice', 'Mice, Inbred C57BL', 'Pregnancy'] | 22,096,492 | [['B01.050'], ['D12.776.260.108.124', 'D12.776.660.167', 'D12.776.930.127.124'], ['D12.776.260.108.184', 'D12.776.930.127.184'], ['G07.345.500.325.235.750', 'G07.345.500.325.377.249', 'G08.686.784.170.157.750'], ['G05.380'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular species delimitation in the Racomitrium canescens complex (Grimmiaceae) and implications for DNA barcoding of species complexes in mosses. | In bryophytes a morphological species concept is still most commonly employed, but delimitation of closely related species based on morphological characters is often difficult. Here we test morphological species circumscriptions in a species complex of the moss genus Racomitrium, the R. canescens complex, based on vari... | ['Base Sequence', 'Bryophyta', 'DNA Barcoding, Taxonomic', 'DNA, Plant', 'Genetic Variation', 'Species Specificity'] | 23,341,927 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.650.940.800.575.137'], ['E05.393.542.249', 'E05.393.760.700.149'], ['D13.444.308.435'], ['G05.365'], ['G16.824']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Diabetic nephropathy and arterial hypertension. | The relationship between arterial blood pressure and diabetic nephropathy was examined in 61 Type 1 (insulin-dependent) diabetic patients (22 females and 39 males). All patients fulfilled the following criteria: persistent proteinuria (greater than 0.5 g/day), onset of diabetes before 31 years of age, age less than 42 ... | ['Adult', 'Aging', 'Blood Pressure', 'Creatinine', 'Diabetic Nephropathies', 'Female', 'Humans', 'Hypertension', 'Male', 'Proteinuria'] | 6,825,976 | [['M01.060.116'], ['G07.345.124'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D03.383.129.308.207'], ['C12.777.419.192', 'C13.351.968.419.192', 'C19.246.099.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['C12.777.934.734', 'C13.351.968.934.734', 'C23.888.942.750']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Anatomy of the medial suprapatellar plica and medial synovial shelf. | The anatomy of the medial suprapatellar plica and medial synovial shelf was studied arthroscopically in 500 knees. The medical suprapatellar plica extended up to one third of the way across the suprapatellar pouch in 64.2% of knees, between one and two thirds in 4%, and two thirds or more in 31.6%. The medial synovial ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Arthroscopy', 'Child', 'Female', 'Humans', 'Knee Joint', 'Male', 'Middle Aged', 'Patella', 'Synovial Membrane'] | 2,363,784 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['M01.060.116.630'], ['A02.835.232.043.650.624', 'A02.835.232.730.500'], ['A02.835.583.443.80... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Early dose response analysis of ocular hypotensive effects of propranolol in patients with ocular hypertension. | Placebo and propranolol (Inderal) in doses of 20, 40, and 80 mg were given in a single-blind test to two groups of six ocular hypertensives. The groups consisted of patients with an intraocular pressure ranging from 20 to 29 mmHg and 30 to 39 mmHg. The doses were given 48 hours apart and administered after fasting 12 h... | ['Adult', 'Aged', 'Clinical Trials as Topic', 'Dose-Response Relationship, Drug', 'Female', 'Glaucoma', 'Humans', 'Intraocular Pressure', 'Male', 'Propranolol'] | 795,456 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['G07.690.773.875', 'G07.690.936.500'], ['C11.525.381'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['D02.033.100.624.698.711', 'D02.033.755.624.698.711', 'D02.092.063.624.698.711', '... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor. | Human neutrophil elastase (HNE), a trypsin-type serine protease, is of pivotal importance in the onset and progression of chronic obstructive pulmonary disease (COPD). COPD encompasses a group of slowly progressive respiratory disorders and is a major medical problem and the fifth leading cause of death worldwide. HNE ... | ['Binding Sites', 'Catalytic Domain', 'Enzyme Inhibitors', 'Humans', 'Leukocyte Elastase', 'Models, Molecular', 'Protein Conformation', 'Pulmonary Disease, Chronic Obstructive', 'Pyrimidines'] | 21,549,129 | [['G02.111.570.120'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['D27.505.519.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.656.300.760.560.500', 'D08.811.277.656.959.350.560.500'], ['E05.599.595'], ['G02.111.570.820.709'], ['C08.381.495.389'], ['D03.383.742']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner. | Fibroblast growth loop (FGL) is a neural cell adhesion molecule (NCAM)-mimetic peptide that mimics the interaction of NCAM with fibroblast growth factor receptor (FGFR). FGL increases neurite outgrowth and promotes neuronal survival in vitro, and it has also been shown to have neuroprotective effects in vivo. More rece... | ['Animals', 'Antigens, CD', 'Astrocytes', 'Biomarkers', 'Cells, Cultured', 'Cytokines', 'Enzyme-Linked Immunosorbent Assay', 'Inflammation', 'Lipopolysaccharides', 'Macrophage Activation', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Neuroglia', 'Peptides', 'RNA, Messenger', 'Real-Time Polymerase Chain Reaction'] | 23,337,536 | [['B01.050'], ['D23.050.301.264.035', 'D23.101.100.110'], ['A08.637.200', 'A11.650.200'], ['D23.101'], ['A11.251'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['C23.550.470'], ['D09.400.500',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel X-linked combined immunodeficiency disease. | A novel X-linked combined immunodeficiency disease was found in five living males in an extended family in the United States. The age of the affected males ranged from 2.5 to 34 yr. The most prominent clinical abnormalities were a paucity of lymphoid tissue; recurrent sinusitis, otitis media, bronchitis, and pneumonia;... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Female', 'Genetic Linkage', 'Humans', 'Immunoglobulins', 'Immunologic Deficiency Syndromes', 'Leukocyte Count', 'Male', 'Pedigree', 'Phenotype', 'T-Lymphocytes', 'X Chromosome'] | 2,243,135 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['G05.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485', 'D12.776.124.790.651', 'D12.776.377.715.548'], ['C20.673'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.200.625.10... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Porcine adipose tissue-derived mesenchymal stem cells retain their proliferative characteristics, senescence, karyotype and plasticity after long-term cryopreservation. | We and others have provided evidence that adipose tissue-derived mesenchymal stem cells (ASCs) can mitigate rat cardiac functional deterioration after myocardial ischemia, even though the mechanism of action or the relevance of these findings to human conditions remains elusive. In this regard, the porcine model is a k... | ['Adipose Tissue', 'Animals', 'Antigens, Surface', 'Cell Differentiation', 'Cell Proliferation', 'Cell Survival', 'Cellular Senescence', 'Cryopreservation', 'Immunophenotyping', 'Karyotype', 'Male', 'Mesenchymal Stem Cells', 'Swine', 'Time Factors', 'Transcriptome'] | 23,874,472 | [['A10.165.114'], ['B01.050'], ['D23.050.301'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['G04.043'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['E01.370.225.812.447', 'E05.200.812.447', 'E... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Possible association of HMOX1 and NQO1 polymorphisms with anti-tuberculosis drug-induced liver injury: A matched case-control study. | WHAT IS KNOWN AND OBJECTIVE: Reactive metabolites from anti-tuberculosis (anti-TB) drugs can result in abnormal accumulation of reactive oxygen species (ROS), which plays an important role in anti-TB drug-induced liver injury (ATLI). Liver cells could keep the production of ROS in balance by antioxidant activities. The... | ['Antitubercular Agents', 'Asian Continental Ancestry Group', 'Case-Control Studies', 'Chemical and Drug Induced Liver Injury', 'Female', 'Genetic Predisposition to Disease', 'Genotype', 'Heme Oxygenase-1', 'Humans', 'Male', 'Middle Aged', 'NAD(P)H Dehydrogenase (Quinone)', 'Polymorphism, Single Nucleotide', 'Tuberculo... | 30,776,144 | [['D27.505.954.122.085.255'], ['M01.686.508.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['D08.811.682.690.708.410.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.06... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enzymatically Modified Low-Density Lipoprotein Promotes Foam Cell Formation in Smooth Muscle Cells via Macropinocytosis and Enhances Receptor-Mediated Uptake of Oxidized Low-Density Lipoprotein. | OBJECTIVE: Enzyme-modified nonoxidized low-density lipoprotein (ELDL) is present in human atherosclerotic lesions. Our objective is to understand the mechanisms of ELDL uptake and its effects on vascular smooth muscle cells (SMC).APPROACH AND RESULTS: Transformation of murine aortic SMCs into foam cells in response to ... | ['Acetylation', 'Animals', 'Atherosclerosis', 'Biological Transport', 'Calcium', 'Calcium Channel Blockers', 'Cells, Cultured', 'Foam Cells', 'Humans', 'Lipoproteins, LDL', 'Macrophages, Peritoneal', 'Mice', 'Mice, Knockout', 'Muscle, Smooth, Vascular', 'Myocytes, Smooth Muscle', 'Phosphatidylinositol 3-Kinase', 'Phosp... | 27,079,883 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['B01.050'], ['C14.907.137.126.307'], ['G03.143'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['A11.251'], ['A11.329.372.368', 'A11.627.482.368', 'A11.733.397.368', 'A15.382.670.522... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Calcium-regulated expression of activin A in RBL-2H3 mast cells. | The present study examined the regulatory expression of activin A, a potent growth and differentiation factor, in rat basophilic leukemia (RBL-2H3) mast cells. Treatment of RBL-2H3 cells sensitized with anti-dinitrophenyl IgE with multivalent dinitrophenyl led to a clear increase in RT-PCR products of inhibin/activin b... | ['Activins', 'Animals', 'Calcium', 'Calmodulin', 'Inhibin-beta Subunits', 'JNK Mitogen-Activated Protein Kinases', 'MAP Kinase Signaling System', 'Mast Cells', 'Mitogen-Activated Protein Kinases', 'Rats', 'Transcriptional Activation', 'Tumor Cells, Cultured', 'p38 Mitogen-Activated Protein Kinases'] | 12,681,448 | [['D06.472.334.500', 'D06.472.699.009', 'D12.644.548.009', 'D12.776.395.022'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['D06.472.334.500.500', 'D06.472.334.968.500', 'D06.472.699.009.500', 'D06.472.699.337.500', 'D12.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preapproval Information Exchange: Perspectives of U.S. Population Health Decision Makers on Preferences for Early Engagement with Investigational Therapies. | BACKGROUND: Preapproval information exchange (PIE) is the communication of clinical and health care economic information (HCEI) on therapies in development between U.S. population health decision makers (PHDMs) and drug manufacturers before regulatory approval. Early access to HCEI can help PHDMs plan budgets, inform f... | ['Budgets', 'Consensus', 'Decision Making', 'Delivery of Health Care', 'Delphi Technique', 'Drug Approval', 'Drug Industry', 'Guidelines as Topic', 'Health Policy', 'Health Services Accessibility', 'Humans', 'Surveys and Questionnaires', 'Therapies, Investigational', 'United States'] | 30,698,089 | [['N03.219.463.060'], ['F01.829.316.068', 'F02.463.785.373.433'], ['F02.463.785.373'], ['N04.590.374', 'N05.300'], ['L01.906.197'], ['E05.290.250', 'E05.337.300', 'I01.880.604.605.250.250'], ['J01.576.655.750'], ['N04.761.700.350', 'N05.700.350'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'... | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 |
Changes in height of jump, maximal voluntary contraction force and low-frequency fatigue after 100 intermittent or continuous jumps with maximal intensity. | Healthy untrained males (age 25.4 +/- 1.7 years, n=12) gave their informed consent to take part in all experiments within the study. After 100 intermittent (every 20 s) drop jumps from the height of 0. 4 m, jumps with counter-movement to 90 degrees angle in the knee and immediate maximal rebound (eccentric-concentric e... | ['Adult', 'Electric Stimulation', 'Energy Metabolism', 'Humans', 'Male', 'Motor Activity', 'Muscle Contraction', 'Muscle Fatigue', 'Muscle Fibers, Skeletal', 'Muscle, Skeletal', 'Physical Exertion', 'Volition'] | 10,759,611 | [['M01.060.116'], ['E05.723.402'], ['G03.295'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.632', 'G11.427.410.698'], ['G11.427.494'], ['G11.427.550'], ['A10.690.552.500.500', 'A11.620.249'], ['A02.633.567', 'A10.690.552.500'], ['G11.427.683'], ['F02.463.902']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Meta-analysis of anthropogenic habitat disturbance effects on animal-mediated seed dispersal. | Anthropogenic habitat disturbance is a strong biodiversity change driver that compromises not only the species persistence but also the ecological interactions in which they are involved. Even though seed dispersal is a key interaction involved in the recruitment of many tree species and in consequence critical for bio... | ['Animals', 'Birds', 'Climate', 'Conservation of Natural Resources', 'Ecosystem', 'Feeding Behavior', 'Insecta', 'Mammals', 'Seed Dispersal'] | 26,149,368 | [['B01.050'], ['B01.050.150.900.248'], ['G16.500.275.071', 'N06.230.300.100.250'], ['J01.256', 'N06.230.080'], ['G16.500.275.157', 'N06.230.124'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.500.131.617'], ['B01.050.150.900.649'], ['G01.154.767', 'G15.620.500', 'G15.808']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Twenty-four-hour time course of intraocular pressure in healthy and glaucomatous Africans: relation to sleep patterns. | OBJECTIVE: The study was performed in early middle-aged African natives with primary open-angle glaucoma to compare the 24-hour intraocular pressure (IOP) variations in healthy versus young glaucoma patients, because IOP follows a circadian (24-hour) oscillation in healthy Caucasians.DESIGN: Case-control study.PARTICIP... | ['Adult', 'African Continental Ancestry Group', 'Case-Control Studies', 'Circadian Rhythm', 'Female', 'Glaucoma, Open-Angle', 'Humans', 'Intraocular Pressure', 'Male', 'Middle Aged', 'Niger', 'Polysomnography', 'Sleep Stages', 'Tonometry, Ocular', 'Wakefulness'] | 11,150,279 | [['M01.060.116'], ['M01.686.508.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G07.180.562.190'], ['C11.525.381.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['M01.060.116.630'], ['Z01.058.290.190.560'], ['E01.370.520.625'], ['F02.830.855.796', 'G11.561.80... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Separation and Analysis of Aspirin and Metformin HCl Using Green Subcritical Water Chromatography. | Organic solvents are widely used in pharmaceutical and chemical industry for chromatographic separations. In recent years, subcritical water chromatography (SBWC) has shown ability in replacing hazardous organic solvents used in traditional high-performance liquid chromatography (HPLC). In this work, a pain killer-aspi... | ['Aspirin', 'Chromatography, High Pressure Liquid', 'Metformin'] | 30,189,589 | [['D02.455.426.559.389.657.410.595.176'], ['E05.196.181.400.300'], ['D02.078.370.141.450']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intron-mediated RNA interference, intronic microRNAs, and applications. | Nearly 97% of the human genome is non-coding DNA. The intron occupies most of it around the gene-coding regions. Numerous intronic sequences have been recently found to encode microRNAs (miRNAs), responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. miRNAs, small single-stranded reg... | ['Animals', 'Chickens', 'Disease', 'Genetic Therapy', 'Humans', 'Introns', 'Mice', 'MicroRNAs', 'Molecular Biology', 'Pluripotent Stem Cells', 'RNA Interference', 'RNA, Small Interfering', 'Zebrafish'] | 20,387,152 | [['B01.050'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['C23.550.288'], ['E02.095.301', 'E05.393.420.301'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515'], ['B01.050.150.900.649.313.992.635.505.500'], ['D13.150.650.319', 'D13.444.735.15... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of size and location of the oligosaccharide chain on protease degradation of bovine pancreatic ribonuclease. | We have investigated the effect of size and location of the oligosaccharide chain on protease degradation of bovine pancreatic ribonuclease. The sensitivity of nonglycosylated RNase A to trypsin and chymotrypsin was compared with three glycosylated species of RNase B which differed with respect to the size of the carbo... | ['Amino Acid Sequence', 'Animals', 'Carbohydrate Sequence', 'Cattle', 'Chymotrypsin', 'Kinetics', 'Oligosaccharides', 'Pancreas', 'Peptide Fragments', 'Ribonuclease, Pancreatic', 'Ribonucleases', 'Structure-Activity Relationship', 'Temperature', 'Trypsin'] | 6,630,185 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.160', 'L01.453.245.667.160'], ['B01.050.150.900.649.313.500.380.271'], ['D08.811.277.656.300.760.176', 'D08.811.277.656.959.350.176'], ['G01.374.661', 'G02.111.490'], ['D09.698.629'], ['A03.734'], ['D12.644.541'], ['D08.811.277.352.355.350.715', 'D... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Regulation of unsaturated fatty acid biosynthesis in Saccharomyces: the endoplasmic reticulum membrane protein, Mga2p, a transcription activator of the OLE1 gene, regulates the stability of the OLE1 mRNA through exosome-mediated mechanisms. | The Saccharomyces cerevisiae OLE1 gene encodes a membrane-bound Delta9 fatty-acid desaturase, whose expression is regulated through transcriptional and mRNA stability controls. In wild type cells grown on fatty acid-free medium, OLE1 mRNA has a half-life of 10 +/- 1.5 min (basal stability) that becomes highly unstable ... | ['Cell Membrane', 'DNA', 'Endoplasmic Reticulum', 'Fatty Acid Desaturases', 'Fatty Acids', 'Fatty Acids, Unsaturated', 'Gene Expression Regulation, Fungal', 'Kinetics', 'Membrane Proteins', 'Models, Genetic', 'Plasmids', 'Promoter Regions, Genetic', 'Protein Structure, Tertiary', 'RNA, Messenger', 'Saccharomyces cerevi... | 15,220,333 | [['A11.284.149'], ['D13.444.308'], ['A11.284.430.214.190.875.248'], ['D08.811.682.690.708.392'], ['D10.251'], ['D10.251.355'], ['G05.308.330'], ['G01.374.661', 'G02.111.490'], ['D12.776.543'], ['E05.599.395.397'], ['G05.360.600'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enzyme-amplified electrochemical biosensor for detection of PML-RARá fusion gene based on hairpin LNA probe. | In this study, an enzyme-amplified electrochemical biosensor was developed for detection of the promyelocytic leukemia/retinoic acid receptor alpha (PML/RARá) fusion gene in acute promyelocytic leukemia (APL). This new sensor employs a hairpin locked nucleic acids (LNAs) probe dually labeled with biotin and carboxyfluo... | ['Biosensing Techniques', 'DNA Probes', 'Electrochemical Techniques', 'Humans', 'Leukemia, Promyelocytic, Acute', 'Oligonucleotides', 'Oncogene Proteins, Fusion', 'Polymerase Chain Reaction', 'Sensitivity and Specificity', 'Spectrophotometry', 'Streptavidin'] | 21,840,703 | [['E05.601.043'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['E05.301'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.275.700'], ['D13.695.578.424'], ['D12.776.602.500.500', 'D12.776.624.664.500'], ['E05.393.620.500'], ['E05.318.370.800', 'E05.318.740.872', 'G17.80... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[The demonstration and specificity of autoreactive T-lymphocytes in type-1 diabetes]. | BACKGROUND AND OBJECTIVE: Type 1 diabetes is characterised by a chronic autoimmune process predominantly transmitted by T-cells. Yet current knowledge about autoimmune reactions in type 1 diabetes transmitted by antigen-specific T-cells is very limited. In this study we investigated T-cell reactivity to potential autoa... | ['Adolescent', 'Adult', 'Autoantigens', 'Autoimmune Diseases', 'Autoimmunity', 'Child', 'Chronic Disease', 'Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 2', 'Epitopes', 'Humans', 'Immunologic Tests', 'Middle Aged', 'T-Lymphocytes', 'Twins'] | 9,229,550 | [['M01.060.057'], ['M01.060.116'], ['D23.050.422'], ['C20.111'], ['G12.450.192'], ['M01.060.406'], ['C23.550.291.500'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C18.452.394.750.149', 'C19.246.300'], ['D23.050.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812', 'E05.200.812', 'E05... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Test/inform/retest: a useful technique in undergraduate rheumatology teaching. | Twenty final year medical students had their ability to interpret rheumatological physical signs tested by 10 multiple choice questions (MCQ) on days 1 and 4 of an educational study. Ten theory questions were used as controls. They were then given an information sheet on the interpretation of physical signs, and repeat... | ['Education, Medical, Undergraduate', 'Prospective Studies', 'Rheumatology', 'Teaching'] | 1,730,107 | [['I02.358.399.450'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['H02.403.429.730'], ['I02.903']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Pulse therapy in pemphigus: report of 11 cases. | In this study, five cases of pemphigus vulgaris and two cases of pemphigus foliaceus were treated with cyclophosphamide pulse therapy associated with prednisone, resulting in the need for a smaller maintenance dose of prednisone. In three cases of pemphigus vulgaris and one case of pemphigus foliaceus, dexamethasone an... | ['Adolescent', 'Adult', 'Cyclophosphamide', 'Dermatologic Agents', 'Dexamethasone', 'Drug Therapy, Combination', 'Female', 'Glucocorticoids', 'Humans', 'Male', 'Middle Aged', 'Pemphigus', 'Prednisone', 'Pulse Therapy, Drug', 'Recurrence', 'Time Factors', 'Treatment Outcome'] | 24,068,153 | [['M01.060.057'], ['M01.060.116'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['D27.505.954.444'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['E02.319.310'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C17.800.865.716... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hesperidin in orange juice reduces the absorption of celiprolol in rats. | It has been reported that the intestinal absorption of celiprolol, an antihypertensive drug, is inhibited when it is taken with orange juice; it has been suggested that element(s) in citrus juice are responsible for this. In the present study, the pharmacokinetic interaction between celiprolol and orange juice was char... | ['Animals', 'Antihypertensive Agents', 'Area Under Curve', 'Beverages', 'Celiprolol', 'Chromatography, Liquid', 'Citrus sinensis', 'Food-Drug Interactions', 'Hesperidin', 'Intestinal Absorption', 'Male', 'Rats', 'Rats, Wistar', 'Spectrometry, Mass, Electrospray Ionization'] | 18,344,215 | [['B01.050'], ['D27.505.954.411.162'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['G07.203.100', 'J02.200'], ['D02.033.100.624.698.268', 'D02.033.755.624.698.268', 'D02.065.950.681.241', 'D02.092.063.624.698.268', 'D02.455.426.559.389.703.241'], ['E05.196.181.400'], ['B01.650.940.800... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[Thrombocyte kinetics before and after gold therapy in rheumatoid arthritis]. | Before and after performing a basic therapy with sanocrysin, thromboytic kinetic examinations were carried out in 12 patients suffering from rheumatoid arthritis. The thrombocyte survival time, maximal recovery and thrombocyte turnover were determined. The surface activity values were given in the form of spleen-heart ... | ['Arthritis, Rheumatoid', 'Blood Platelets', 'Cell Survival', 'Gold', 'Humans', 'Indomethacin', 'Liver', 'Myocardium', 'Spleen'] | 64,411 | [['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['A11.118.188', 'A15.145.229.188'], ['G04.346'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473.420'], ['A03.620'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['A... | ['Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Memory-driven attentional capture reveals the waxing and waning of working memory activation due to dual-task interference. | Previous studies have shown that information held in working memory (WM) actively or as a residue of previous processing can lead to attentional capture by corresponding stimuli in the environment. Here, we compared attentional capture by goal-driven and residual WM activation and examined how these effects are affecte... | ['Adult', 'Attention', 'Executive Function', 'Female', 'Humans', 'Male', 'Memory, Short-Term', 'Young Adult'] | 27,125,221 | [['M01.060.116'], ['F02.830.104.214'], ['F02.463.217'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.407'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Uracil-DNA glycosylase (UNG) influences the melting temperature (T(m)) of herpes simplex virus (HSV) hybridization probes. | Prior to PCR amplification, uracil-DNA glycosylase (UNG) can be incorporated to prevent amplicon contamination. Melting temperature (T(m)) analysis of herpes simplex virus (HSV) hybridization probes was used to demonstrate a concentration-dependent decrease in T(m) values when heat stabile or heat labile UNG was added. | ['DNA Probes', 'DNA, Viral', 'Enzyme Stability', 'Herpes Simplex', 'Herpesvirus 1, Human', 'Herpesvirus 2, Human', 'Hot Temperature', 'Humans', 'Nucleic Acid Hybridization', 'Polymerase Chain Reaction', 'Transition Temperature', 'Uracil-DNA Glycosidase'] | 18,468,698 | [['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['D13.444.308.568'], ['E05.916.360', 'G02.111.700.500'], ['C01.925.256.466.382', 'C01.925.825.320', 'C17.800.838.790.320'], ['B04.280.382.100.750.390'], ['B04.280.382.100.750.440'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.75... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
In vivo assembly of the tau-complex of the DNA polymerase III holoenzyme expressed from a five-gene artificial operon. Cleavage of the tau-complex to form a mixed gamma-tau-complex by the OmpT protease. | A plasmid was constructed that encodes all five subunits of the Escherichia coli tau-complex on a single artificially constructed operon under the control of an inducible promoter. The proteins tau, delta, delta , chi, and psi overproduced from this artificial operon assemble efficiently in vivo, providing an efficient... | ['Base Sequence', 'Cloning, Molecular', 'DNA Polymerase II', 'Escherichia coli', 'Macromolecular Substances', 'Molecular Sequence Data', 'Oligodeoxyribonucleotides', 'Operon', 'Plasmids', 'Protein Processing, Post-Translational', 'Serine Endopeptidases'] | 8,626,597 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D08.811.913.696.445.308.300.230'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D05'], ['L01.453.245.667'], ['D13.695.578.424.450'], ['G05.360.340.024.686', 'G05.360.340.358.207.500'], ['G05.360.600'], ['G02.111.660.871.790.600'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Evaluation, surveillance and treatment of panoral leukoplakia. | Leukoplakia is well-recognised as a premalignant condition of the oral mucosa. Despite many attempts to produce definitive laboratory tests for the prediction of those cases of premalignant leukoplakia which may undergo malignant transformation, there is as yet no fool-proof method of clinical and laboratory assessment... | ['Aged', 'Cryosurgery', 'Cytodiagnosis', 'Humans', 'Leukoplakia, Oral', 'Precancerous Conditions', 'Staining and Labeling'] | 54,399 | [['M01.060.116.100'], ['E04.014.180'], ['E01.370.225.500.384', 'E05.200.500.384', 'E05.242.384'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.591.545', 'C04.834.512.513', 'C07.465.530.545', 'C23.300.816.513'], ['C04.834'], ['E01.370.225.500.620.670', 'E01.370.225.750.600.670', 'E05.200.500.620.670', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Transforming growth factor-beta 2 both stimulates and inhibits neurogenesis of rat cerebellar granule cells in culture. | Transforming growth factor-beta 2 (TGF beta 2) is expressed in the developing cerebellar cortex during the period of granule cell proliferation and maturation. However, the role of TGF beta 2 in granule cell development is confused by conflicting observations regarding TGF beta 2 control of neurogenesis. To resolve the... | ['Animals', 'Cell Division', 'Cells, Cultured', 'Cerebellum', 'Linear Models', 'Neurons', 'Rats', 'Transforming Growth Factor beta'] | 8,922,667 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['A08.186.211.132.810.428.200'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['A08.675',... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Outpatient perineal sling in adolescent boys with neurogenic incontinence. | PURPOSE: Management for urinary incontinence in boys with sphincteric incompetence secondary to a neurogenic etiology is a challenge. Minimally invasive approaches have inconsistent efficacy and may require multiple treatments. Open bladder neck reconstruction requires inpatient hospitalizations and can be associated w... | ['Adolescent', 'Ambulatory Surgical Procedures', 'Humans', 'Male', 'Polypropylenes', 'Retrospective Studies', 'Suburethral Slings', 'Urinary Bladder, Neurogenic', 'Urinary Incontinence', 'Urologic Surgical Procedures, Male', 'Young Adult'] | 19,692,039 | [['M01.060.057'], ['E04.030'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.326.271.665.590', 'D05.750.716.550', 'D25.720.716.550', 'J01.637.051.720.716.550'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Placenta percreta and uterine rupture associated with prior whole body radiation therapy. | BACKGROUND: Injury to reproductive organs including the uterus is a known complication of ionizing radiation, but the risks to the mother and fetus during subsequent pregnancies are not well defined.CASE: A young woman with a remote history of whole body irradiation for childhood leukemia had uterine rupture at 17 week... | ['Adult', 'Female', 'Humans', 'Placenta Accreta', 'Pregnancy', 'Radiation Injuries', 'Uterine Rupture', 'Uterus', 'Whole-Body Irradiation'] | 11,704,208 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.703.420.643', 'C13.703.590.609'], ['G08.686.784.769'], ['C26.733', 'G01.750.748.500', 'N06.850.460.350.850.500', 'N06.850.810.300.360'], ['C13.351.500.852.904', 'C13.703.420.904', 'C26.761.853'], ['A05.360.319.679'], ['E02.815.814', 'E05.980']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Value of turbo-spin-echo sequences in cerebral magnetic resonance tomography in children]. | AIM: The value of turbo-spin-echo (TSE) sequences was compared with conventional spin-echo (SE) and inversion-recovery (IR) sequences for cerebral MRT in 70 children at 0.5 T and 1.5 T. In addition we evaluated whether proton weighted sequences (PD) were diagnostically important and in what proportion of cases.METHOD: ... | ['Adolescent', 'Age Factors', 'Brain', 'Brain Diseases', 'Child', 'Child, Preschool', 'Evaluation Studies as Topic', 'Humans', 'Infant', 'Infant, Newborn', 'Magnetic Resonance Imaging'] | 7,670,014 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['A08.186.211'], ['C10.228.140'], ['M01.060.406'], ['M01.060.406.448'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E01.370.350.825.500']] | ['Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Glutamatergic chloride currents associated to glutamate transport? | Especially in arthropod glutamatergic synaptic systems, microM l-glutamate (Glu) concentrations often elicit Cl- currents, in addition to the excitatory cationic currents that are triggered by much higher Glu concentrations. In crayfish, Ibotenate (Ibo) is a specific agonist of the Glu-ergic Cl- currents. Application o... | ['Amino Acid Transport System X-AG', 'Animals', 'Chloride Channel Agonists', 'Chloride Channels', 'Dose-Response Relationship, Drug', 'Excitatory Postsynaptic Potentials', 'Glutamic Acid', 'Ibotenic Acid', 'In Vitro Techniques'] | 15,755,521 | [['D12.776.157.530.200.249.500', 'D12.776.157.530.937.250', 'D12.776.543.585.200.249.500', 'D12.776.543.585.937.250'], ['B01.050'], ['D27.505.519.562.311'], ['D12.776.157.530.400.175', 'D12.776.543.550.450.175', 'D12.776.543.585.400.175'], ['G07.690.773.875', 'G07.690.936.500'], ['G04.580.887.249', 'G07.265.675.887.249... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Drinking on the premises in Norway: young adults' use of public drinking places. | In this paper various aspects of young adults' use of premises licensed to sell alcoholic beverages are discussed. Data were obtained from national surveys of drinking habits in 1999 and 2004 (SIRUS), and the age group was 18 to 34 years. Bivariate methods showed a positive association between drinking in licensed prem... | ['Adolescent', 'Adult', 'Alcohol Drinking', 'Alcoholic Intoxication', 'Female', 'Humans', 'Licensure', 'Male', 'Norway', 'Public Facilities', 'Regression Analysis', 'Social Responsibility'] | 17,490,826 | [['M01.060.057'], ['M01.060.116'], ['F01.145.317.269'], ['C25.775.100.175', 'F03.900.100.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.706.110.510', 'N05.700.200.450'], ['Z01.542.816.374'], ['J03.720'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['F01.829.500.760', 'K01.752.566.8... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Tailoring of temperature- and pH-responsive cotton fabric with antimicrobial activity: Effect of the concentration of a bio-barrier-forming agent. | A stimuli-responsive cotton fabric was designed using temperature and pH-responsive poly-N-isopropylacrylamide (poly-NiPAAm) and chitosan (PNCS) microgel as a carrier of antimicrobially active 3-(trimethoxysilyl)-propyldimethyloctadecyl ammonium chloride (Si-QAC), which forms a bio-barrier on the fibre surface. The inf... | ['Acrylic Resins', 'Anti-Infective Agents', 'Chitosan', 'Drug Carriers', 'Escherichia coli', 'Gossypium', 'Hydrogen-Ion Concentration', 'Organosilicon Compounds', 'Quaternary Ammonium Compounds', 'Spectroscopy, Fourier Transform Infrared', 'Staphylococcus aureus', 'Temperature', 'Textiles'] | 28,821,119 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['D27.505.954.122'], ['D05.750.078.139.500', 'D09.698.211.500'], ['D26.255.260', 'E02.319.300.380'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.650.940.800.575.912.250.859.821.500.244'], ['G02.300'], ['D02.756'], ['D01.62... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Isolation of mycoplasma membranes by digitonin. | The cell membrane of Mycoplasma hominis was isolated by lysing the cells with digitonin. Electron microscopy and chemical, density gradient, and electrophoretic analyses of the membrane proteins showed the membranes so obtained, like those isolated by osmotic lysis, to be relatively free of cytoplasmic contaminants. Se... | ['Bacterial Proteins', 'Bacteriological Techniques', 'Bacteriolysis', 'Cell Fractionation', 'Cell Membrane', 'Cholesterol', 'Culture Media', 'Densitometry', 'Drug Resistance, Microbial', 'Electrophoresis, Disc', 'Magnesium', 'Microscopy, Electron', 'Mycoplasma', 'Oleic Acids', 'Osmolar Concentration', 'Phosphotungstic ... | 4,112,256 | [['D12.776.097'], ['E01.370.225.875.150', 'E05.200.875.150'], ['G06.099.115'], ['E05.242.251'], ['A11.284.149'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D27.720.470.305', 'E07.206'], ['E05.196.712.224'], ['G06.225', 'G07.690.773.984.269'], ['E05.196.401.402.236', 'E05.301.300.319.40... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Differences in the action of typical and atypical tranquilizers on the structure and function of mitochondria during emotional-painful stress]. | Experiments were made to study the effect of a typical (chlorodiasepoxide) and an atypical (lithonite) tranquilizers on the structure and function of mitochondria in emotional-painful stress. It was demonstrated that emotional-painful stress gives rise to the disturbance of the activity of mitochondrial enzymes respons... | ['Animals', 'Brain', 'Chlordiazepoxide', 'Energy Metabolism', 'Humans', 'Male', 'Mitochondria', 'Nicotinic Acids', 'Rats', 'Rats, Inbred Strains', 'Somatosensory Cortex', 'Stress, Psychological', 'Tranquilizing Agents'] | 6,540,123 | [['B01.050'], ['A08.186.211'], ['D03.633.100.079.080.150'], ['G03.295'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['D03.066.515', 'D03.383.725.547'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Why Should We Abolish Daylight Saving Time? | Local and national governments around the world are currently considering the elimination of the annual switch to and from Daylight Saving Time (DST). As an international organization of scientists dedicated to studying circadian and other biological rhythms, the Society for Research on Biological Rhythms (SRBR) engage... | ['Circadian Rhythm', 'Humans', 'Light', 'Photoperiod', 'Seasons', 'Solar System', 'Time Factors'] | 31,170,882 | [['G07.180.562.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['G01.910.675'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['G01.060.075.730'], ['G01.910.857']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
C-Jun N-terminal kinase (JNK) regulation of iNOS expression in glial cells: predominant role of JNK1 isoform. | The mitogen-activated protein kinases (MAPKs) play a central role in mediating the activation and transcriptional responses of diverse cells, including glia. c-Jun N-terminal kinase (JNK), a member of the MAPK family, is activated by a variety of stress and proinflammatory signals and in turn phosphorylates its downstr... | ['Animals', 'Anthracenes', 'Astrocytes', 'Cells, Cultured', 'Enzyme Activation', 'Interferon-gamma', 'Isoenzymes', 'JNK Mitogen-Activated Protein Kinases', 'Lipopolysaccharides', 'Mitogen-Activated Protein Kinase 8', 'Nitric Oxide Synthase Type II', 'RNA, Small Interfering', 'Rats', 'Tumor Necrosis Factor-alpha'] | 16,771,680 | [['B01.050'], ['D02.455.426.559.847.117', 'D04.615.117'], ['A08.637.200', 'A11.650.200'], ['A11.251'], ['G02.111.263', 'G03.328'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893', 'D23.529.374.480.615.350'], ['D08.811.348', 'D12.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anomalous origin of the left coronary artery from the right pulmonary artery associated with complex congenital heart disease. | The rare coexistence of anomalous origin of the left coronary artery from the main pulmonary artery with other cardiac malformations prompts us to report an unusual case of anomalous origin of the left coronary artery from the right pulmonary artery associated with complete atrioventricular canal, patent ductus arterio... | ['Abnormalities, Multiple', 'Coronary Angiography', 'Coronary Vessel Anomalies', 'Female', 'Heart Defects, Congenital', 'Humans', 'Infant, Newborn', 'Pulmonary Artery'] | 7,060,119 | [['C16.131.077'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.240.400.210', 'C14.280.400.210', 'C16.131.240.400.210'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['A07.015.114.715']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Optimization of kinetic energy harvesters design for fully implantable Cochlear Implants. | Fully implantable Cochlear Implants (CIs) would represent a tremendous advancement in terms of quality of life, comfort and cosmetics, for patients with profound sensorineural deafness. One of the main challenges involved in the development of such implants consists of finding a power supply means which does not requir... | ['Algorithms', 'Cochlear Implants', 'Computer Simulation', 'Fourier Analysis', 'Kinetics', 'Prosthesis Design', 'Thermodynamics'] | 22,256,117 | [['G17.035', 'L01.224.050'], ['E07.305.250.319.381.500.500', 'E07.695.150', 'E07.695.202.381.500.500', 'E07.814.458.150'], ['L01.224.160'], ['E05.377', 'G17.226', 'L01.224.800.625'], ['G01.374.661', 'G02.111.490'], ['E05.320.550', 'E07.695.680'], ['G01.906']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Acute myocardial infarction as the first manifestation of Takayasu arteritis: A case report. | RATIONALE: Takayasu arteritis (TA) is a chronic inflammatory disease involving the aorta and its major branches. Initial diagnosis is usually difficult due to the highly variable symptoms. Acute myocardial infarction (AMI) is a very rare presentation in patients with TA. Moreover, the choice of early management for the... | ['Adult', 'Combined Modality Therapy', 'Diagnosis, Differential', 'Female', 'Humans', 'Myocardial Infarction', 'Takayasu Arteritis'] | 30,985,685 | [['M01.060.116'], ['E02.186'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['C14.907.109.239.650', 'C14.907.940.090.800', 'C17.800.862.875']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Copper(II) complexes of terminally free alloferon mutants containing two histidyl binding sites inside peptide chain structure and stability. | Mononuclear and polynuclear copper(II) complexes of alloferon 1 with point mutations, H1A/H12A H2N-A(1)GVSGH(6)GQH(9)GVA(12)G-COOH, H1A/H9A H2N-A(1)GVSGH(6)GQA(9)GVH(12)G-COOH, and H1A/H6A H2N-A(1)GVSGA(6)GQH(9)GVH(12)G-COOH, have been studied by potentiometric, UV-visible, CD, and EPR spectroscopy, and mass spectromet... | ['Binding Sites', 'Coordination Complexes', 'Copper', 'Hydrogen-Ion Concentration', 'Peptides', 'Point Mutation', 'Potentiometry', 'Spectrometry, Mass, Electrospray Ionization', 'Spectrophotometry, Ultraviolet'] | 26,565,558 | [['G02.111.570.120'], ['D01.234', 'D02.257'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['G02.300'], ['D12.644'], ['G05.365.590.675'], ['E05.196.922.750', 'E05.301.710'], ['E05.196.566.600'], ['E05.196.712.726.802', 'E05.196.867.826.802']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study. | OBJECTIVES: To investigate the performance of classic risk factors, and of some new biomarkers, in predicting cardiovascular mortality in very old people from the general population with no history of cardiovascular disease.DESIGN: The Leiden 85-plus Study (1997-2004) is an observational prospective cohort study with 5... | ['Aged, 80 and over', 'Biomarkers', 'Cardiovascular Diseases', 'Cohort Studies', 'Female', 'Humans', 'Male', 'Netherlands', 'Risk Assessment', 'Risk Factors'] | 19,131,384 | [['M01.060.116.100.080'], ['D23.101'], ['C14'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.651'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715']... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Biochemistry and genetics of esterase-20 (ES-20), a second trimeric carboxylesterase of the house mouse (Mus musculus). I. Purification and characterization of ES-20C1 from male kidney. | ES-20 was isolated from male mouse kidney and purified 350-fold by ion-exchange chromatography, isoelectric focusing, and gel filtration. The resultant product was apparently homogeneous by the criteria of polyacrylamide gel electrophoresis and immunodiffusion and represented a major fraction of male mouse kidney ester... | ['Animals', 'Carboxylic Ester Hydrolases', 'Hydrogen-Ion Concentration', 'Kidney', 'Kinetics', 'Male', 'Mice', 'Mice, Inbred Strains', 'Molecular Weight'] | 4,084,215 | [['B01.050'], ['D08.811.277.352.100'], ['G02.300'], ['A05.810.453'], ['G01.374.661', 'G02.111.490'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['G02.494']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lung function and breathing regulation parameters during pregnancy. | AIM: The aim of this study was to evaluate the changes in lung function and breathing regulation parameters measured in women who did not suffer from any respiratory system disorders (in comparison with body mass index values obtained before pregnancy) in any particular trimester of pregnancy.METHODS: The study was car... | ['Adult', 'Analysis of Variance', 'Body Mass Index', 'Case-Control Studies', 'Female', 'Humans', 'Lung', 'Pregnancy', 'Respiration', 'Risk Factors', 'Spirometry'] | 15,616,844 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Global processing training to improve visuospatial memory deficits after right-brain stroke. | Visuospatial stimuli are normally perceived from the global structure to local details. A right-brain stroke often disrupts this perceptual organization, resulting in piecemeal encoding and thus poor visuospatial memory. Using a randomized controlled design, the present study examined whether promoting the global-to-lo... | ['Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Male', 'Memory Disorders', 'Middle Aged', 'Neuropsychological Tests', 'Space Perception', 'Stroke', 'Stroke Rehabilitation', 'Treatment Outcome', 'Visual Perception'] | 23,070,314 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.525', 'C23.888.592.604.529', 'F01.700.625'], ['M01.060.116.630'], ['F04.711.513'], ['F02.463.593.778'], ['C10.228.140.300.775', 'C14.907.253.855'], ['E02.760.169.063.500.477.500', 'E02.831.477.500', 'H02.403.68... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Vinorelbine plus Capecitabine (Vinocap): a retrospective analysis in heavily pretreated HER2 negative metastatic breast cancer patients. | PURPOSE: Metastatic breast cancer is regarded as an incurable entity. In heavily pretreated patients with increasingly limited options for palliative management, ensuring proper quality of life continues is to be an elusive issue. With this in mind, the authors evaluated the efficacy and safety of the Vinorelbine/Capec... | ['Adult', 'Aged', 'Antimetabolites, Antineoplastic', 'Antineoplastic Agents, Phytogenic', 'Antineoplastic Combined Chemotherapy Protocols', 'Breast Neoplasms', 'Capecitabine', 'Female', 'Humans', 'Middle Aged', 'Neoplasm Metastasis', 'Quality of Life', 'Receptor, ErbB-2', 'Retrospective Studies', 'Survival Analysis', '... | 30,900,138 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['D27.505.954.248.179'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.180', 'C17.800.090.500'], ['D03.383.742.680.245.500.425', 'D03.383.742.698.875.404.425', 'D13.570.230.329.313', 'D13... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Maternal periodontal disease in early pregnancy and risk for a small-for-gestational-age infant. | OBJECTIVE: The objective of the study was to determine whether periodontal disease is associated with delivery of a small-for-gestational-age infant.STUDY DESIGN: In a prospective study of oral health, periodontal disease was categorized as health, mild, or moderate/severe on the basis of clinical criteria. Small for g... | ['Adult', 'Case-Control Studies', 'Female', 'Humans', 'Infant, Newborn', 'Infant, Small for Gestational Age', 'Periodontal Diseases', 'Pregnancy', 'Pregnancy Complications', 'Prospective Studies', 'Risk Factors', 'Severity of Illness Index'] | 16,647,916 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.460.560'], ['C07.465.714'], ['G08.686.784.769'], ['C13.703'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sensitivity analysis for healthcare models fitted to data by statistical methods. | After fitting complex models to data using statistical methods, a sensitivity analysis can be carried out. This determines which parts of a model are causing the bulk of the uncertainty in the model predictions (model "output"), and is a decision-support tool for the modeller who contemplates refining a model further o... | ['Breast Neoplasms', 'Cost-Benefit Analysis', 'Decision Support Techniques', 'Decision Theory', 'Delivery of Health Care', 'Health Policy', 'Humans', 'Likelihood Functions', 'Mass Screening', 'Models, Statistical', 'Sensitivity and Specificity', 'State Medicine', 'United Kingdom'] | 12,437,275 | [['C04.588.180', 'C17.800.090.500'], ['N03.219.151.125'], ['E05.245', 'L01.313.500.750.190'], ['G17.162'], ['N04.590.374', 'N05.300'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.5... | ['Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Aberrant muscle syndrome: hypertrophy of the hand and arm due to aberrant muscles with or without hypertrophy of the muscles. | Five patients were reported in our congenital anomaly registry who had six hands in total with muscular hyperplasia, aberrant muscles, ulnar drift of the fingers in the metacarpophalangeal (MP) joints, flexion contractures of the MP joints, and enlargement of the metacarpal spaces. Thirty patients with unilateral invol... | ['Adolescent', 'Child, Preschool', 'Female', 'Fingers', 'Hand Deformities, Congenital', 'Humans', 'Hypertrophy', 'Male', 'Muscle, Skeletal', 'Muscular Diseases', 'Syndrome', 'Upper Extremity Deformities, Congenital'] | 20,214,671 | [['M01.060.057'], ['M01.060.406.448'], ['A01.378.800.667.430'], ['C05.390.408', 'C05.660.585.988.425', 'C16.131.621.585.988.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.300.775'], ['A02.633.567', 'A10.690.552.500'], ['C05.651', 'C10.668.491'], ['C23.550.288.500'], ['C05.660.585.988', 'C16.131.621.585.9... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Concepts of behaviorally oriented assertiveness training, problems of differentiating between assertive and aggressive behavior]. | This article demonstrates the failing of hitherto attempts to differentiate between assertive and aggressive behavior and points out the necessity to develop more appropriate models for the treatment of interpersonal communication problems. | ['Aggression', 'Assertiveness', 'Behavior Therapy', 'Communication', 'Humans', 'Social Adjustment'] | 7,415,372 | [['F01.145.126.125', 'F01.145.813.045'], ['F01.752.049'], ['F04.754.137'], ['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.813.621']] | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Foetus in foetu--a case report. | A three-month old baby presented to the Paediatric Department with a problem of abdominal distension. Clinically, he had a large right abdominal mass which on investigations suggested a teratomatous lesion. At operation, a foetus-like tumour mass was located in the retroperitoneal space. A diagnosis of foetus in foetu ... | ['Abdominal Neoplasms', 'Diagnosis, Differential', 'Fetus', 'Humans', 'Infant', 'Male', 'Radiography', 'Retroperitoneal Neoplasms', 'Teratoma', 'Twins'] | 2,617,306 | [['C04.588.033'], ['E01.171'], ['A16.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.350.700'], ['C04.588.033.731'], ['C04.557.465.910'], ['M01.438.873']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Spatial performance of unilateral vestibular defective patients in nonvisual versus visual navigation. | The purpose of this study was to investigate the effects of unilateral vestibular neurotomy on humans ability to perform navigation tasks. These tasks provided self-motion feedback by way of either locomotor activity only (nonvisual navigation or "locomotor task") or visual motion cues only (visually simulated navigati... | ['Distance Perception', 'Female', 'Humans', 'Kinesthesis', 'Locomotion', 'Male', 'Meniere Disease', 'Middle Aged', 'Orientation', 'Proprioception', 'Social Environment', 'Visual Perception'] | 10,334,015 | [['F02.463.593.200.390', 'F02.463.593.778.255.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.830.816.541.504', 'G11.561.790.541.587'], ['G07.568.500', 'G11.427.410.568'], ['C09.218.568.217.500'], ['M01.060.116.630'], ['F01.058.577', 'F02.830.606'], ['F02.830.816.541', 'G07.888.750', 'G11.561.790.541'], [... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Breast lesions: imaging with contrast-enhanced subharmonic US--initial experience. | PURPOSE: To prospectively compare accuracy of gray-scale subharmonic imaging (SHI) with that of standard gray-scale ultrasonography (US), power Doppler US (with and without contrast material), and mammography for the diagnosis of breast cancer, with histopathologic or clinical follow-up results as the reference standar... | ['Adult', 'Aged', 'Albumins', 'Breast Neoplasms', 'Chi-Square Distribution', 'Contrast Media', 'Diagnosis, Differential', 'Female', 'Fluorocarbons', 'Humans', 'Mammography', 'Middle Aged', 'Pilot Projects', 'Predictive Value of Tests', 'Prospective Studies', 'ROC Curve', 'Sensitivity and Specificity', 'Ultrasonography,... | 17,690,324 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.034'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['D27.505.259.500', 'D27.720.259'], ['E01.171'], ['D02.455.526.510.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Functional linkage of the cardiac ATP-sensitive K+ channel to the actin cytoskeleton. | The role of the cytoskeleton in the rundown and reactivation of adenosine triphosphate (ATP) sensitive K+ channels (KATP channels) was examined by perturbing selectively the intracellular surface of inside-out membrane patches excised from guinea-pig ventricular myocytes. Actin filament-depolymerizing agents (cytochala... | ['Actins', 'Adenosine Triphosphate', 'Animals', 'Colchicine', 'Cytochalasin D', 'Cytoskeleton', 'Guinea Pigs', 'Heart', 'Heart Ventricles', 'Myocardium', 'Phosphatidylinositol 4,5-Diphosphate', 'Phosphatidylinositol Phosphates', 'Potassium Channels', 'Ventricular Function'] | 8,596,692 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D03.132.225'], ['D03.633.100.473.231.450', 'D23.946.587.370.450'], ['A11.284.430.214.190.750'], ['B01.050.150.900.649.313.992.550'], ['A07.541'], ['A07.54... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Survival of the very-low-birth-weight infants after cardiopulmonary resuscitation in neonatal intensive care unit. | OBJECTIVE: To assess whether advances in neonatal care in the last decade have altered the outcome of very-low-birth-weight (VLBW) infants after cardiopulmonary resuscitation (CPR) in the neonatal intensive care unit (NICU).STUDY DESIGN: Medical records of all VLBW infants (n=283, body weight (BW)=1066+/-281 g, gestati... | ['Birth Weight', 'Cardiopulmonary Resuscitation', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Infant, Premature, Diseases', 'Infant, Very Low Birth Weight', 'Intensive Care Units, Neonatal', 'Louisiana', 'Survival Analysis', 'Therapeutics'] | 15,042,108 | [['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E02.365.647.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['C16.614.521'], ['M01.060.703.520.460.600'], ['N02.278.388.493.39... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Surface properties of inclusion complexes between alpha-cyclodextrin and poly(ethylene oxide). | The surface properties of the supramolecular inclusion complex (IC) obtained from the threading of alpha-cyclodextrin (alpha-CD) onto poly(ethylene oxide) (PEO) free in solution are studied. The complexes were characterized by IR, (1)H NMR spectroscopy, and thermal analysis. The variation of the interfacial tension, ga... | ['Macromolecular Substances', 'Polyethylene Glycols', 'Surface Properties', 'Surface Tension', 'Temperature', 'Thermodynamics', 'Water', 'alpha-Cyclodextrins'] | 16,780,856 | [['D05'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], ['G02.860'], ['G02.860.816'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.906'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925'], ['D04.345... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Characterization of nonrapid virologic response patients infected with HCV genotype 1 who may relapse after standard therapy with peginterferon plus ribavirin. | Approximately 50% of patients with hepatitis C virus (HCV) genotype 1 treated with peginterferon alfa-2a/ribavirin discontinue treatment early or experience a suboptimal response despite 48 weeks of therapy. The objective of this analysis was to develop a model to identify nonrapid virologic response (non-RVR) patients... | ['Adult', 'Aged', 'Antiviral Agents', 'Female', 'Genotype', 'Hepacivirus', 'Hepatitis C, Chronic', 'Humans', 'Interferon-alpha', 'Male', 'Middle Aged', 'Models, Statistical', 'Polyethylene Glycols', 'Prognosis', 'Recombinant Proteins', 'Recurrence', 'Retrospective Studies', 'Ribavirin', 'Risk Assessment', 'Sensitivity ... | 22,239,499 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.388'], ['G05.380'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', 'C06.552.380.705.440.120'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890.250... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Repair of furcal perforation treated with mineral trioxide aggregate in a primary molar tooth: 20-month follow-up. | Furcal perforations may occur during access opening of the pulp chamber or cavity preparation. The perforation can cause an inflammatory reaction in the periodontal ligament. Management of these iatrogenic accidents can pose a significant clinical challenge, mainly when they occur in primary teeth. Current developments... | ['Aluminum Compounds', 'Calcium Compounds', 'Child', 'Dental Pulp Cavity', 'Drug Combinations', 'Follow-Up Studies', 'Glass Ionomer Cements', 'Humans', 'Iatrogenic Disease', 'Male', 'Molar', 'Oxides', 'Periapical Diseases', 'Pulpotomy', 'Retreatment', 'Root Canal Filling Materials', 'Silicates', 'Tooth Root', 'Tooth, D... | 18,647,517 | [['D01.056'], ['D01.146'], ['M01.060.406'], ['A14.549.167.900.265'], ['D26.310'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['D25.339.291.402', 'J01.637.051.339.291.402'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.291.875'], ['A14.549.167.860.525'], ['D0... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
DAB389IL2 diphtheria fusion toxin produces clinical responses in tumor stage cutaneous T cell lymphoma. | Four patients with late stage cutaneous T cell lymphoma (IB-IVA) who had failed at least two previous therapies were treated with DAB389IL2 at 9 or 18 microg/kg as 15-min intravenous infusions daily for 5 days every 3 weeks for eight cycles. Mild vascular leak syndrome (VLS) with transient edema, hypoalbuminemia, weigh... | ['Administration, Topical', 'Adult', 'Diphtheria Toxin', 'Female', 'Humans', 'Interleukin-2', 'Lymphoma, T-Cell', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Recombinant Fusion Proteins', 'Skin Neoplasms', 'Treatment Outcome'] | 9,590,158 | [['E02.319.267.120'], ['M01.060.116'], ['D08.811.913.400.725.115.220', 'D23.946.123.305'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D12.776.467.374.480.372', 'D23.529.374.465.155', 'D23.529.374.480.372'], ['C04.557.386.480.750', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evidence-based veterinary medicine: a clear and present challenge. | If evidence-based veterinary medicine is to become a reality, the veterinary profession must be both prepared and in a position to undertake the necessary research, says Lance Lanyon. | ['Animals', 'Biomedical Research', 'Evidence-Based Medicine', 'Humans', 'United Kingdom', 'Veterinary Medicine'] | 24,526,538 | [['B01.050'], ['H01.770.644.145'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.363'], ['H02.956']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Edentulousness in patients attending a university dental clinic. | The purpose of this study was to establish base-line data on the prevalence of edentulism in adult patients seeking care at the College of Dentistry, in the City of Saskatoon. Out of a total of 548 patients, 75 (13.7 per cent) were totally edentulous. However, there were no individuals edentulous only in the mandible. ... | ['Adult', 'Age Factors', 'Aged', 'Dental Clinics', 'Female', 'Humans', 'Jaw, Edentulous', 'Male', 'Middle Aged', 'Mouth, Edentulous', 'Saskatchewan', 'Schools, Dental', 'Sex Factors'] | 2,645,031 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['N02.278.192.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.500.480', 'C07.320.550', 'C07.465.550.425', 'C07.793.597.425'], ['M01.060.116.630'], ['C07.465.550', 'C07.793.597'], ['Z01.107.567.176.858'], ['I02.783.495.481'], ['... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Chemical structure of nuclear proteins which are phosphorylated during meiotic maturation of starfish oocytes. | Oocytes of the starfish, Asterina pectinifera, are arrested at the G2 phase of meiosis I and possess a prominent germinal vesicle in which maternal stores of nuclear proteins which are destined for use primarily by the early embryo are stored. Germinal vesicle breakdown and subsequent oocyte maturation is triggered by ... | ['Amino Acid Sequence', 'Animals', 'CDC2 Protein Kinase', 'Consensus Sequence', 'Conserved Sequence', 'DNA-Binding Proteins', 'Evolution, Molecular', 'Female', 'G2 Phase', 'Humans', 'Meiosis', 'Molecular Sequence Data', 'Nuclear Proteins', 'Oocytes', 'Peptide Fragments', 'Phosphorylation', 'Sea Urchins', 'Sequence Alig... | 10,828,953 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D08.811.913.696.620.682.700.646.500.500.250', 'D08.811.913.696.620.682.700.646.500.984.500', 'D12.644.360.250.067.249', 'D12.644.360.250.580.500', 'D12.776.167.200.067.249', 'D12.776.167.200.580.500', 'D12.776.476.250.067.249', 'D12.776.476.250.580.500', 'D12.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Interpretation of polymorphic DNA patterns in the human alpha-amylase multigene family. | Previous molecular studies have clearly shown that the human amylase locus has a very complicated structure. Multiple salivary and pancreatic amylase genes are present on haplotypes with variable numbers of genes. To study the population heterogeneity, human genomic DNA from family members and random individuals was di... | ['Blotting, Southern', 'Crossing Over, Genetic', 'DNA', 'Deoxyribonucleases, Type II Site-Specific', 'Genes', 'Haplotypes', 'Humans', 'Models, Genetic', 'Multigene Family', 'Pedigree', 'Polymorphism, Restriction Fragment Length', 'Pseudogenes', 'alpha-Amylases'] | 1,679,752 | [['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['G05.728.615.200'], ['D13.444.308'], ['D08.811.150.280.260', 'D08.811.277.352.335.350.300.260', 'D08.811.277.352.355.325.300.260'], ['G05.360.340.024.340'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.397'], ['G05.360.340.024.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Men Sustain Higher Dysregulation Levels Than Women Without Becoming Frail. | The aging process differs in important ways between the sexes, with women living longer but at higher risk for frailty (the male-female health-survival paradox). The underlying biological mechanisms remain poorly understood, but may relate to sex differences in physiological dysregulation patterns. Here, using biomarke... | ['Aged', 'Aged, 80 and over', 'Aging', 'Biomarkers', 'Female', 'Frail Elderly', 'Homeostasis', 'Humans', 'Male', 'Middle Aged', 'Mortality', 'Sex Characteristics'] | 28,977,345 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['D23.101'], ['M01.060.116.100.540'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.505.400.975.550', 'N06.850.520.308.985.550'], ['G08.686.815']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Autoantibodies to gliadin-binding 90 kDa glycoprotein in coeliac disease. | Patients with untreated coeliac disease were found to have high concentrations of circulating antibodies to 90 kDa glycoprotein, a mannose rich protein found in skin and intestinal mucosa. In contrast, patients with active Crohn's disease or ulcerative colitis had antibody concentrations within the normal range. In coe... | ['Adolescent', 'Adult', 'Aged', 'Antigens, Neoplasm', 'Autoantibodies', 'Biomarkers, Tumor', 'Carrier Proteins', 'Celiac Disease', 'Colitis, Ulcerative', 'Crohn Disease', 'Gliadin', 'Glutens', 'Glycoproteins', 'Humans', 'Middle Aged', 'Plant Proteins', 'Rheumatic Diseases'] | 3,485,069 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D23.050.285'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D23.101.140'], ['D12.776.157'], ['C06.405.469.637.250', 'C18.452.603.250'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
De novo concurrent 5p deletion and distal 17q duplication identified by fluorescence in situ hybridization (FISH). | A de novo case of unbalanced 5p/17q translocation showing a concurrent 5p deletion and distal 17q duplication has initially eluded a definitive cytogenetic identification based on chromosome banding patterns and clinical features. But it is subsequently unequivocally identified by fluorescence in situ hybridization tec... | ['Chromosome Deletion', 'Chromosomes, Human, Pair 17', 'Chromosomes, Human, Pair 5', 'Humans', 'In Situ Hybridization, Fluorescence', 'Infant, Newborn', 'Karyotyping', 'Male', 'Multigene Family', 'Translocation, Genetic'] | 8,166,430 | [['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G05.558.800.180', 'G05.700.131.500.500'], ['A11.284.187.520.300.415.425', 'G05.360.162.520.300.415.425'], ['A11.284.187.520.300.280.290', 'G05.360.162.520.300.280.290'], ['B01.050.150.900.649.313.988.400.112.4... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Perioperative outcome after laparoscopic radiofrequency ablation of liver tumors: an analysis of 521 cases. | BACKGROUND: Radiofrequency thermal ablation (RFA) is gaining increased acceptance for the treatment of unresectable primary and metastatic liver tumors. Understanding the morbidity and laboratory changes after RFA is important for operative indications and perioperative management.METHODS: The authors prospectively ana... | ['Adult', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Biopsy, Needle', 'Catheter Ablation', 'Cohort Studies', 'Female', 'Follow-Up Studies', 'Hepatectomy', 'Humans', 'Immunohistochemistry', 'Laparoscopy', 'Liver Function Tests', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Perioperative Care... | 17,287,917 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
International EMS systems: France. | The EMS (Emergency Medical Service) system in France is a centrally based, two-tiered, physician-manned system. The first level is composed of BLS (Basic Life Support) fire department ambulances (called "VSAB") based at fire stations. The second level is composed of ALS (Advanced Life Support) physician staffed-ambulan... | ['Emergency Medical Services', 'France', 'International Cooperation', 'Workforce'] | 15,451,580 | [['N02.421.297'], ['Z01.542.286'], ['I01.615.500'], ['N04.452.525']] | ['Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Cutting stress off at the pass: reducing vigilance and responsiveness to social threat by manipulating attention. | Personality processes relating to social perception have been shown to play a significant role in the experience of stress. In 5 studies, the authors demonstrate that early stage attentional processes influence the perception of social threat and modify the human stress response. The authors first show that cortisol re... | ['Adult', 'Arousal', 'Attention', 'Brain', 'Facial Expression', 'Female', 'Habituation, Psychophysiologic', 'Humans', 'Hydrocortisone', 'Internal-External Control', 'Magnetic Resonance Imaging', 'Male', 'Pattern Recognition, Visual', 'Rejection, Psychology', 'Self Concept', 'Set, Psychology', 'Social Perception', 'Stre... | 17,892,337 | [['M01.060.116'], ['F02.830.104', 'G11.561.035'], ['F02.830.104.214'], ['A08.186.211'], ['E01.370.600.225', 'F01.145.209.530.385'], ['F02.463.425.393', 'F02.830.422', 'G11.561.312'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], [... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Biodegradation of kraft-lignin by Bacillus sp. isolated from sludge of pulp and paper mill. | Eight bacterial strains were isolated on kraft lignin (KL) containing mineral salt medium (L-MSM) agar with glucose and peptone from the sludge of pulp and paper mill. Out of these, ITRC-S8 was selected for KL degradation, because of its fast growth at highest tested KL concentration and use of various lignin-related l... | ['Bacillus', 'Biodegradation, Environmental', 'DNA, Ribosomal', 'Gas Chromatography-Mass Spectrometry', 'Hydrogen-Ion Concentration', 'Industrial Waste', 'Lignin', 'Molecular Weight', 'Paper', 'Phylogeny', 'Sewage'] | 17,308,883 | [['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['D13.444.308.475'], ['E05.196.181.349.500', 'E05.196.566.500'], ['G02.300'], ['D20.944.420', 'N06.850.460.710.420'], ['D05.750.078.562.180.51... | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Effect of marrow on the high frequency ultrasonic properties of cancellous bone. | A number of investigators have performed in vitro measurements of cancellous bone to determine how various ultrasonic parameters depend on bone density and trabecular orientation. To facilitate handling and storage of bone specimens, the marrow is often removed prior to ultrasonic measurements. However, the assumption ... | ['Animals', 'Bone Density', 'Bone Marrow', 'Bone and Bones', 'Cattle', 'Scattering, Radiation', 'Tibia', 'Ultrasonics', 'Ultrasonography'] | 12,375,829 | [['B01.050'], ['G11.427.100'], ['A15.382.216'], ['A02.835.232', 'A10.165.265'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.822', 'G01.867'], ['A02.835.232.043.650.883'], ['H01.671.031.849'], ['E01.370.350.850']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Biliary catheter drainage complicated by hemobilia: treatment by balloon embolotherapy. | Seventeen patients experienced severe hemobilia following percutaneous (nine patients) or surgical (eight patients) placement of biliary drainage catheters. Fourteen patients bled early after catheter placement (0.5-32 weeks; mean, 5.4 weeks) and three bled late during long-term biliary drainage (1.1-3.6 years; mean, 2... | ['Adult', 'Aged', 'Bile Ducts', 'Catheterization', 'Drainage', 'Embolization, Therapeutic', 'Female', 'Follow-Up Studies', 'Hemobilia', 'Hepatic Artery', 'Humans', 'Male', 'Middle Aged', 'Punctures', 'Radiography'] | 4,059,553 | [['M01.060.116'], ['M01.060.116.100'], ['A03.159.183'], ['E02.148', 'E05.157'], ['E02.309', 'E04.237'], ['E02.520.360', 'E02.926.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C23.550.414.864'], ['A07.015.114.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
N-myc down regulates neural cell adhesion molecule expression in rat neuroblastoma. | In human neuroblastoma, amplification of the N-myc oncogene is correlated with increased metastatic ability. We recently showed that transfection of the rat neuroblastoma cell line B104 with an N-myc expression vector resulted in an increase in metastatic ability and a significant reduction in the expression of major h... | ['Animals', 'Cell Adhesion Molecules, Neuronal', 'Cloning, Molecular', 'Fluorescent Antibody Technique', 'Gene Expression Regulation', 'Molecular Weight', 'Neuroblastoma', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-myc', 'RNA, Messenger', 'Rats', 'Transfection'] | 2,183,016 | [['B01.050'], ['D12.776.395.550.200.250', 'D12.776.543.550.200.250', 'D23.050.301.350.250'], ['E05.393.220'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['G05.308'], ['G02.494'], ['C04.557.465.625.600.590.650.550', 'C04.557.47... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of hemorrhage and resuscitation on serum levels of immunoreactive atrial natriuretic factor. | To determine if atrial natriuretic factor (ANF) might have a role in blood volume regulation during hypovolemia, the serum level was measured before and after hemorrhage and resuscitation (RESUS) in a porcine shock model. Hemorrhage of 40% of the blood volume produced significant (p less than 0.01) decreases in mean ar... | ['Animals', 'Atrial Natriuretic Factor', 'Catecholamines', 'Diuresis', 'Female', 'Fluid Therapy', 'Hemodynamics', 'Male', 'Natriuresis', 'Radioimmunoassay', 'Renin', 'Shock, Hemorrhagic', 'Swine'] | 2,963,597 | [['B01.050'], ['D06.472.699.584.500', 'D12.644.548.585.500'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['G08.852.179'], ['E02.319.360'], ['G09.330.380'], ['G08.852.179.557'], ['E01.370.384.700', 'E05.478.566.639', 'E05.601.470.639'], ['D08.811.277.656.074.500.780', 'D08.811.277.656.300.048.780', 'D08.811.277... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pelvic fractures at a new level 1 trauma centre: who dies from pelvic trauma? The Inkosi Albert Luthuli Central Hospital experience. | OBJECTIVE: To identify the incidence of pelvic trauma, causes of death and factors predicting death with pelvic fractures.METHODS: All pelvic fractures were retrospectively identified from a registry spanning from March 2007 to August 2009. Data was captured on a proforma. Data for survivors, non-survivors and a subgro... | ['Accidental Falls', 'Accidents, Traffic', 'Adolescent', 'Adult', 'Aged', 'Blood Transfusion', 'Cause of Death', 'Child', 'Child, Preschool', 'Female', 'Fractures, Bone', 'Humans', 'Male', 'Middle Aged', 'Pelvic Bones', 'Retrospective Studies', 'South Africa', 'Trauma Centers', 'Treatment Outcome', 'Young Adult'] | 23,109,305 | [['N06.850.135.122'], ['N06.850.135.392'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.095.135'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['M01.060.406'], ['M01.060.406.448'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.40... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
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