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Scale insect genus-group names and their families (Hemiptera: Sternorrhyncha: Coccoidea).
|
Genus names of the scale insects (Hemiptera: Coccoidea) are listed with their current families. The list includes all generic names that are currently valid with synonyms, unjustified emendations, homonyms, nomia nuda and misspellings. The list has been compiled from many sources as discussed in the introduction. This is the first list to be prepared in recent years of all generic names and it is in alphabetical order.
|
['Animals', 'Biodiversity', 'Checklist', 'Hemiptera', 'Terminology as Topic']
| 24,943,268
|
[['B01.050'], ['G16.500.275.157.049', 'N06.230.124.049'], ['N05.715.360.300.179'], ['B01.050.500.131.617.412'], ['L01.559.598.400']]
|
['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]']
| 0
| 1
| 0
| 0
| 0
| 0
| 1
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Uterine glands of the pig during pregnancy. An ultrastructural and cytochemical study.
|
The ultrastructure of the porcine uterine glands is described from material taken from 11 pregnant pigs at exactly known stages of gestation (day 30; 58; 80; 100; 110). Fixation was performed by perfusion via a branch of the uterine artery and the tissue was routinely processed for electron microscopy. Additionally, cytochemical studies (phosphotungstic acid reaction for glycoproteins, according to Rambourg 1967; acid phosphatase reaction; ultrastructural localization of cellular iron, according to Parmley et al. 1978) were performed. On day 30 of pregnancy the uterine glands are coiled, simple tubular glands with a narrow lumen. The epithelial lining is simple columnar and consists basically of two cell types, ciliated cells and secretory cells. The secretory activity of the glandular epithelium is low; only a few secretory granules are present in the supranuclear cytoplasm. At midpregnancy the ultrastructure of the glands has significantly changed and the cells now show all the characteristics of high secretory activity: numerous parallel cisternae of rough endoplasmic reticulum, an extensively developed Golgi apparatus and many secretory granules which give a positive reaction for acid phosphatase and glycoproteins. The lumina of the glands are significantly enlarged and filled with a great amount of a granular, acid phosphatase-positive material. In the last third of pregnancy, only minor changes in the ultrastructure of the uterine glands are observed. The secretory activity is still high. The amount of rough endoplasmic reticulum has further increased and parallel arrays of cisternae occupy a considerable part of the supranuclear cytoplasm. The importance of the uterine secretion for embryonic nutrition and development is only partly understood. One of the secreted glycoproteins, uteroferrin, is believed to play an important role in the iron transfer from mother to fetus. From midpregnancy onward, a special cell type, the "granule laden cell" is found scattered between normal secretory cells of the uterine glands. Contrary to the opinion of Perry and Cromby (1982), we could demonstrate that these cells frequently extend to the lumen of the gland; hence the term "basal cell" seems inappropriate for this cell type.
|
['Acid Phosphatase', 'Animals', 'Cytoplasmic Granules', 'Exocrine Glands', 'Female', 'Pregnancy', 'Pregnancy, Animal', 'Swine', 'Time Factors', 'Uterus']
| 6,837,929
|
[['D08.811.277.352.650.025'], ['B01.050'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['A10.336'], ['G08.686.784.769'], ['G08.686.784.769.498'], ['B01.050.150.900.649.313.500.880'], ['G01.910.857'], ['A05.360.319.679']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]']
| 1
| 1
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| 1
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Lighting-up the dynamics of telomerization and DNA replication by CdSe-ZnS quantum dots.
|
CdSe-ZnS core-shell quantum dots (QDs) act as photochemical centers for lighting-up the dynamics of telomerization or DNA replication.
|
['Cadmium Compounds', 'DNA', 'DNA Replication', 'Deoxyribonucleotides', 'Fluorescence Resonance Energy Transfer', 'HeLa Cells', 'Humans', 'Nanotechnology', 'Particle Size', 'Photochemistry', 'Quantum Dots', 'Selenium Compounds', 'Sulfides', 'Telomerase', 'Telomere', 'Thermodynamics', 'Zinc Compounds']
| 14,611,202
|
[['D01.142'], ['D13.444.308'], ['G02.111.225', 'G05.226'], ['D13.695.201'], ['E05.196.712.516.600.676.500', 'G01.154.240.280', 'G02.111.255.280'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.603', 'J01.897.520.600'], ['G02.712'], ['H01.181.529.711'], ['E07.705', 'J01.637.512.600.650'], ['D01.810'], ['D01.248.497.158.874', 'D01.875.350.850', 'D02.886.520'], ['D08.811.913.696.445.308.300.750.750', 'D12.776.157.687.613', 'D12.776.157.725.500.921', 'D12.776.660.720.613', 'D12.776.664.962.500.921'], ['A11.284.430.106.279.345.190.160.845', 'G05.360.160.845'], ['G01.906'], ['D01.975']]
|
['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]']
| 1
| 1
| 0
| 1
| 1
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| 1
| 1
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Functional breast imaging using the single photon technique.
|
Early diagnosis of carcinoma of the breast is currently attempted by mammography and physical examination which together have a sensitivity of 85%. Mammography has a positive predictive value of only 15 to 40 percent. The usefulness of scintimammography for the detection of carcinoma of the breast has been studied which demonstrated improved specificity compared to conventional mammography. In future, with the development or dedicated breast imager and new targeted radiopharmaceuticals, we can achieve detection of smaller than 1 cm carcinoma. This type of imaging enables us to detect cancer at its 'pre-anatomic' stage.
|
['Breast Neoplasms', 'False Positive Reactions', 'Female', 'Humans', 'Sensitivity and Specificity', 'Tomography, Emission-Computed, Single-Photon']
| 12,089,481
|
[['C04.588.180', 'C17.800.090.500'], ['E01.354.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['E01.370.350.350.800.800', 'E01.370.350.600.350.800.800', 'E01.370.350.710.800.800', 'E01.370.350.825.800.800', 'E01.370.384.730.800.800']]
|
['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]']
| 0
| 1
| 1
| 0
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| 0
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Microbial detoxification of metalaxyl in aquatic system.
|
Four microorganisms, Pseudomonas sp. (ER2), Aspergillus niger (ER6), Cladosporium herbarum (ER4) and Penicilluim sp. (ER3), were isolated from cucumber leaves previously treated with metalaxyl using enrichment technique. These isolates were evaluated for detoxification of metalaxyl at the recommended dose level in aquatic system. The effect of pH and temperature on the growth ability of the tested isolates was also investigated by measuring the intracellular protein and mycelia dry weight for bacterial and fungal isolates, respectively. Moreover, the toxicity of metalaxyl after 28 d of treatment with the tested isolates was evaluated to confirm the complete removal of any toxic materials (metalaxyl and its metabolites). The results showed that the optimum degree pH for the growth of metalaxyl degrading isolates (bacterial and fungal isolates) was 7. The temperature 30 degrees C appeared to be the optimum degree for the growth of either fungal or bacterial isolates. The results showed that Pseudomonas sp. (ER2) was the most effective isolate in metalaxyl degradation followed by Aspergillus niger (ER6), Cladosporium herbarum (ER4) and Penicilluim sp. (ER3), respectively. There is no toxicity of metalaxyl detected in the supernatant after 28 d of treatment with Pseudomonas sp. (ER2). The results suggest that bioremediation by Pseudomonas sp. (ER2) isolate was considered to be effective method for detoxification of metalaxyl in aqueous media.
|
['Alanine', 'Aspergillus niger', 'Biodegradation, Environmental', 'Cladosporium', 'Hydrogen-Ion Concentration', 'Penicillium', 'Pseudomonas', 'Temperature', 'Water Microbiology', 'Water Pollutants, Chemical']
| 18,595,390
|
[['D12.125.042'], ['B01.300.381.081.450'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['B01.300.381.200'], ['G02.300'], ['B01.300.381.662'], ['B03.440.400.425.625.625', 'B03.660.250.580.590'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['H01.158.273.540.274.777', 'N06.850.425.450'], ['D27.888.284.903.655']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]']
| 0
| 1
| 0
| 1
| 0
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 1
| 0
|
The French version of the HSCL-25 has now been validated for use in primary care.
|
BACKGROUND: The Hopkins Symptom Checklist in 25 items (HSCL-25) helps to assess anxiety and depression in Primary Care. Anxiety and depression show considerable overlap in primary care. This self-administrated questionnaire is valid, reliable and ergonomic in the original US version. We have translated it into French. The aim of this study was to estimate the test characteristics of the HSCL-25, in its French version (F-HSCL-25), by comparing it to the Present State Examination-9 French version (F-PSE-9) and by determining its internal validity and dimensions.METHOD: Outpatients from three French General Practice settings (rural, semi-rural and urban) were recruited: approximately 20,000 outpatients among 17 GPs. Two groups were formed: F-HSCL-25 ?1.75 and F-HSCL-25 <1.75. A validated cut-off score of > 1.75 was considered to indicate a clinically relevant level of symptoms of depression and anxiety. In order to obtain two balanced groups, a different method of randomization was chosen for each group. The F-PSE-9 was randomly administered to 1 in 2 patients in the F-HSCL-25 ?1.75 group, and to 1 in 16 in the (much larger) F-HSCL-25 <1.75 group. The diagnostic performance was assessed and the test results obtained from both groups were compared with their F-PSE-9 results.RESULTS: Of the 1126 patients who completed the F-HCL-25, 886 joined the F-HSCL-25 <1.75 group and 240 the F-HSCL-25 ?1.75 group. The overall prevalence of depression, using the F-HSCL-25, was 21% in these medical practices. The diagnostic performance of the F-HSCL-25 versus the F-PSE-9, the external criteria were as follows: Positive Predictive Value (PPV) 69.8%, Negative Predictive Value (NPV) 87%; Sensitivity 59.1%, and Specificity 91.4%. The Principal Component Analysis showed that F-HSCL-25 is a one-dimensional tool (anxiety and depression dimensions combined) with a Cronbach Alpha of 0.93.CONCLUSION: The F-HSCL-25 is an appropriate diagnostic tool for anxiety and depression in primary care in France due to its high specificity and high NPV. The HSCL-25 scale has a high eigenvalue. This pilot study will be extended throughout Europe; however, preliminary evidence suggests that the HSCL-25 is a reliable and suitable diagnostic tool for primary care.
|
['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anxiety', 'Depression', 'Female', 'France', 'Humans', 'Male', 'Middle Aged', 'Pilot Projects', 'Primary Health Care', 'Psychometrics', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Surveys and Questionnaires', 'Translations', 'Young Adult']
| 30,946,774
|
[['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.470.132'], ['F01.145.126.350'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['N04.590.233.727'], ['F04.711.780'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['L01.178.682.920'], ['M01.060.116.815']]
|
['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]']
| 0
| 1
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| 1
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The creator of the term 'anancasm' was Hungarian: Guyla Don?th (1849-1944).
|
There is considerable confusion in the field of research on the history of psychiatry as to who created the term anancasm. This article seeks to clarify that the term was coined by the Hungarian psychiatrist Gyula Don?th, who was born in Baja, on the Danube, and worked mainly in Budapest. Don?th's publications reveal that his predominant sphere of interest and research was neurology and psychiatry. A number of his publications deal with epilepsy and obsessive-compulsive disorders. After a period of intensive research, during which he spent some time in Berlin at the clinic of neuroscientist Carl Westphal, Don?th proposed the term 'anancasm' in 1895 to describe compulsive mental processes.
|
['Compulsive Behavior', 'History, 19th Century', 'Humans', 'Hungary', 'Obsessive-Compulsive Disorder', 'Psychiatry', 'Terminology as Topic']
| 26,574,062
|
[['F01.145.527.100'], ['K01.400.504.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.248.495'], ['F03.080.600'], ['F04.096.544', 'H02.403.690'], ['L01.559.598.400']]
|
['Psychiatry and Psychology [F]', 'Humanities [K]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Information Science [L]']
| 0
| 1
| 0
| 0
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|
Altered Expression of IFN-ë2 in Allergic Airway Disorders and Identification of Its Cell Origins.
|
This study investigated the expression levels of interferon- (IFN-) ë2 in peripheral blood and tissues. The results showed that the levels of IFN-ë2 were elevated by 17.9% and 14.2% in the plasma of allergic rhinitis (AR) and combined rhinitis with asthma (AR + AS), which was positively correlated with the level of tryptase but negatively correlated with the level of IL-10. IFN-ë2 was predominately expressed in the CD16+ cells and CD14+ cells in healthy control subjects (HC) but upregulated only in CD8+ cells of AR and in eosinophils of asthma. It was observed that approximately 6.6% and 7.0% dispersed tonsil cells and 5.8% and 0.44% dispersed lung cells are IFN-ë2+ mast cells and macrophages. Moreover, tryptase and agonist peptides of PAR-2 induced enhanced IFN-ë2 mRNA expression in A549 cells. In conclusion, the elevated levels of IFN-ë2 in the plasma of AR and AR + AS indicate that IFN-ë2 is likely to contribute to the pathogenesis of allergic airway disorders. The potential origins of the elevated plasma IFN-ë2 include mast cells, macrophages, and epithelial cells in tissues, neutrophils, monocytes, CD8+ T cells, and eosinophils in peripheral blood. Development of IFN-ë2 related therapy may help to treat or prevent allergic airway disorders.
|
['Adolescent', 'Adult', 'Aged', 'Asthma', 'CD8-Positive T-Lymphocytes', 'Cell Line', 'Eosinophils', 'Female', 'Humans', 'Immunohistochemistry', 'Interleukin-10', 'Interleukins', 'Male', 'Middle Aged', 'Neutrophils', 'Rhinitis, Allergic', 'Young Adult']
| 27,057,098
|
[['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['A11.251.210'], ['A11.118.637.415.345', 'A11.627.340.345', 'A15.145.229.637.415.345', 'A15.382.490.315.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510', 'D23.529.374.465.510'], ['D12.644.276.374.465', 'D12.776.467.374.465', 'D23.529.374.465'], ['M01.060.116.630'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145.229.637.415.583', 'A15.382.490.315.583', 'A15.382.680.689'], ['C08.460.799.315', 'C08.674.453', 'C09.603.799.315', 'C20.543.480.680.443'], ['M01.060.116.815']]
|
['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]']
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 1
| 0
| 0
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|
Altered responsiveness of diabetic dog renal arteries to acetylcholine and phenylephrine: role of endothelium.
|
The mechanical responses to acetylcholine (ACh), sodium nitroprusside and phenylephrine (PE) were determined in normal and diabetic dog renal arterial strips with and without endothelium. Experimental diabetes increased the sensitivity, IC50 = (2.9 +/- 0.4) X 10(-8) mol/l in normal and (9.6 +/- 1.5) X 10(-9) mol/l in diabetic (p less than 0.01, n = 6) to ACh of endothelium intact renal arterial strips without influencing the maximum relaxation induced by this agonist. In all intact vessels PE produced contractions of equal magnitude. Removal of the endothelium completely abolished the relaxant ability of ACh, and caused a slight increase in the contractile response of both diabetic and normal strips to PE. The maximum contractile force generated by the denuded diabetic vessels in response to PE was significantly (p less than 0.01) greater than the maximum tension produced by the denuded nondiabetic arteries. The sensitivity of the tissues to PE was, however, not modified by either diabetes or endothelium removal. The direct relaxant sodium nitroprusside elicited a similar degree of relaxation in the two groups of arteries. Cyclooxygenase blockade had no effect on either the relaxation or contractile responses of any of the preparations. These findings suggest that short-term diabetes makes dog renal arteries supersensitive to ACh and hyperreactive to PE.
|
['Acetylcholine', 'Animals', 'Arteries', 'Diabetes Mellitus, Experimental', 'Dogs', 'Endothelium, Vascular', 'Female', 'Male', 'Muscle Contraction', 'Muscle, Smooth, Vascular', 'Nitroprusside', 'Phenylephrine']
| 2,727,056
|
[['D02.092.211.111'], ['B01.050'], ['A07.015.114'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['B01.050.150.900.649.313.750.250.216.200'], ['A07.015.700.500', 'A10.272.491.355'], ['G11.427.494'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.467.491'], ['D01.248.497.158.291.350.550', 'D01.490.100.300.550', 'D01.625.400.100.325.550'], ['D02.033.100.291.617', 'D02.092.063.291.617']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Experimental lung collapse following deployment of a self-expandable bronchial occluder in a rabbit model.
|
OBJECTIVES: Closure of a bronchopleural fistula is required to prevent fatal empyema or aspiration pneumonia. The purpose of this study was to determine the feasibility and efficacy of bronchial occlusion with a self-expandable occluder to induce experimental lung collapse in a rabbit model.METHODS: 10 bronchial occluders (wine glass appearance; 8 mm in diameter and 15 mm in length) were implanted in the native left main bronchi of 10 rabbits via an endotracheal route. We analysed the following: (1) diameters and morphological changes of the bronchial occluders during follow-up; (2) percentage volume of the collapsed lung during follow-up; and (3) complications and gross pathology. 1-day and 2-week follow-up CT scans were routinely obtained. Rabbits were sacrificed 4 weeks after the experiment.RESULTS: In all 10 rabbits, the bronchial occluders were successfully implanted and were completely expanded within 2 weeks. Complete collapse of the left lung occurred in three rabbits on day 1 and in an additional two rabbits 2 weeks following implantation. Two other rabbits maintained the percentage volume of the collapsed lung between 51% and 99% during follow-up; the other three rabbits had <50% during follow-up. Pneumothoraces occurred in nine rabbits, but completely resolved at the 2-week follow-up. Right lung herniation across the midline progressed 2 weeks after occluder implantation.CONCLUSION: Placement of self-expandable occluders in a rabbit bronchus model was feasible and showed a potential to induce artificial lung collapse. While pneumothoraces were common, they resolved during follow-up.
|
['Animals', 'Bronchi', 'Disease Models, Animal', 'Feasibility Studies', 'Imaging, Three-Dimensional', 'Prosthesis Design', 'Pulmonary Atelectasis', 'Rabbits', 'Stents', 'Tomography, X-Ray Computed']
| 21,385,911
|
[['B01.050'], ['A04.411.125'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E01.370.350.400', 'L01.224.308.410'], ['E05.320.550', 'E07.695.680'], ['C08.381.730'], ['B01.050.150.900.649.313.968.700'], ['E07.695.750'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']]
|
['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 1
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| 1
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|
Characterizing cardiac involvement in amyloidosis using cardiovascular magnetic resonance diffusion tensor imaging.
|
BACKGROUND: In-vivo cardiovascular magnetic resonance (CMR) diffusion tensor imaging (DTI) allows imaging of alterations of cardiac fiber architecture in diseased hearts. Cardiac amyloidosis (CA) causes myocardial infiltration of misfolded proteins with unknown consequences for myocardial microstructure. This study applied CMR DTI in CA to assess microstructural alterations and their consequences for myocardial function compared to healthy controls.METHODS: Ten patients with CA (8 AL, 2 ATTR) and ten healthy controls were studied using a diffusion-weighed second-order motion-compensated spin-echo sequence at 1.5 T. Additionally, left ventricular morphology, ejection fraction, strain and native T1 values were obtained in all subjects. In CA patients, T1 mapping was repeated after the administration of gadolinium for extracellular volume fraction (ECV) calculation. CMR DTI analysis was performed to yield the scalar diffusion metrics mean diffusivity (MD) and fractional anisotropy (FA) as well as the characteristics of myofiber orientation including helix, transverse and E2A sheet angle (HA, TA, E2A).RESULTS: MD and FA were found to be significantly different between CA patients and healthy controls (MD 1.77 ± 0.17 10- 3 vs 1.41 ± 0.07 10- 3 mm2/s, p < 0.001; FA 0.25 ± 0.04 vs 0.35 ± 0.03, p < 0.001). MD demonstrated an excellent correlation with native T1 (r = 0.908, p < 0.001) while FA showed a significant correlation with ECV in the CA population (r = - 0.851, p < 0.002). HA exhibited a more circumferential orientation of myofibers in CA patients, in conjunction with a higher TA standard deviation and a higher absolute E2A sheet angle. The transmural HA slope was found to be strongly correlated with the global longitudinal strain (r = 0.921, p < 0.001).CONCLUSION: CMR DTI reveals significant alterations of scalar diffusion metrics in CA patients versus healthy controls. Elevated MD and lower FA values indicate myocardial disarray with higher diffusion in CA that correlates well with native T1 and ECV measures. In CA patients, CMR DTI showed pronounced circumferential orientation of the myofibers, which may provide the rationale for the reduction of global longitudinal strain that occurs in amyloidosis patients. Accordingly, CMR DTI captures specific features of amyloid infiltration, which provides a deeper understanding of the microstructural consequences of CA.
|
['Aged', 'Amyloidosis', 'Cardiomyopathies', 'Case-Control Studies', 'Contrast Media', 'Diffusion Tensor Imaging', 'Female', 'Humans', 'Magnetic Resonance Imaging, Cine', 'Male', 'Middle Aged', 'Myocardium', 'Organometallic Compounds', 'Predictive Value of Tests', 'Prospective Studies', 'Stroke Volume', 'Ventricular Function, Left']
| 31,484,544
|
[['M01.060.116.100'], ['C18.452.845.500'], ['C14.280.238'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D27.505.259.500', 'D27.720.259'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500.510'], ['M01.060.116.630'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['D02.691'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.370.380.150.700', 'G09.330.380.124.882'], ['G09.330.955.800']]
|
['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
In vivo confocal endomicroscopy of small intestinal mucosal morphology in dogs.
|
BACKGROUND: Confocal endomicroscopy (CEM) is an endoscopic technology that permits in vivo cellular and subcellular imaging of the gastrointestinal mucosa.OBJECTIVE: To determine the feasibility of CEM to evaluate small intestinal mucosal topologic morphology in dogs and to characterize the appearance in healthy dogs.ANIMALS: Fourteen clinically healthy research colony dogs.METHODS: Experimental study. Dogs were anesthetized for standard endoscopic evaluation of the small intestine followed by CEM. Two fluorophores were used to provide contrast: fluorescein (10% solution, 15 mg/kg IV) before administration of topical acriflavine (0.05% solution) via an endoscopy spray catheter. A minimum of 5 sites within the small intestine were assessed and at each location, sequential adjustment of imaging depth allowed collection of a three-dimensional volume equivalent to an 'optical biopsy'. CEM-guided pinch biopsies were obtained for histologic examination.RESULTS: CEM provided high-quality in vivo cellular and subcellular images. Intravenous administration of fluorescein provided sufficient contrast to allow assessment of the vasculature, cellular cytoplasmic features and goblet cell numbers, and distribution. Topical application of acriflavine preferentially stained cellular nucleic acids, allowing evaluation of nuclear morphology. Quality of captured images was occasionally affected by motion artifact, but improved with operator experience.CONCLUSION AND CLINICAL IMPORTANCE: CEM provides in vivo images that allow for cellular and subcellular assessment of intestinal mucosal morphology during endoscopy. This has implications for aiding in vivo diagnosis of gastrointestinal disease.
|
['Acriflavine', 'Animals', 'Biopsy', 'Dogs', 'Endoscopy, Gastrointestinal', 'Female', 'Fluorescein', 'Histocytochemistry', 'Intestinal Mucosa', 'Intestine, Small', 'Male', 'Microscopy, Confocal']
| 24,128,334
|
[['D03.633.300.046.250.177'], ['B01.050'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04.210.240.250', 'E04.502.250.250.250'], ['D02.455.426.779.347.390', 'D03.633.300.953.275.390', 'D04.711.347.390'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['A03.556.124.369', 'A10.615.550.444'], ['A03.556.124.684'], ['E01.370.350.515.395', 'E05.595.395']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]']
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
|
Impact of anthropogenic activities on water quality of Lidder River in Kashmir Himalayas.
|
The pristine waters of Kashmir Himalaya are showing signs of deterioration due to multiple reasons. This study researches the causes of deteriorating water quality in the Lidder River, one of the main tributaries of Jhelum River in Kashmir Himalaya. The land use and land cover of the Lidder catchment were generated using multi-spectral, bi-seasonal IRS LISS III (October 2005 and May 2006) satellite data to identify the extent of agriculture and horticulture lands that are the main non-point sources of pollution at the catchment scale. A total of 12 water quality parameters were analyzed over a period of 1 year. Water sampling was done at eight different sampling sites, each with a varied topography and distinct land use/land cover, along the length of Lidder River. It was observed that water quality deteriorated during the months of June-August that coincides with the peak tourist flow and maximal agricultural/horticultural activity. Total phosphorus, orthophosphate phosphorus, nitrate nitrogen, and ammoniacal nitrogen showed higher concentration in the months of July and August, while the concentration of dissolved oxygen decreased in the same period, resulting in deterioration in water quality. Moreover, tourism influx in the Lidder Valley shows a drastic increase through the years, and particularly, the number of tourists visiting the valley has increased in the summer months from June to September, which is also responsible for deteriorating the water quality of Lidder River. In addition to this, the extensive use of fertilizers and pesticides in the agriculture and horticulture lands during the growing season (June-August) is also responsible for the deteriorating water quality of Lidder River.
|
['Agriculture', 'Environmental Monitoring', 'Fertilizers', 'India', 'Nitrogen', 'Phosphorus', 'Rivers', 'Seasons', 'Water Pollutants, Chemical', 'Water Pollution, Chemical', 'Water Quality']
| 23,001,554
|
[['J01.040'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D27.720.031.400'], ['Z01.252.245.393'], ['D01.268.604', 'D01.362.625'], ['D01.268.666'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['D27.888.284.903.655'], ['N06.850.460.790.410'], ['N06.850.460.350.080.750', 'N06.850.460.790.730']]
|
['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]']
| 0
| 0
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 1
|
Perinatal features of congenital cystic lung diseases: results of a nationwide multicentric study in Japan.
|
PURPOSE: The current study aimed to assess the perinatal risk and clinical features of congenital cystic lung diseases (CCLD).MATERIALS AND METHODS: Of the 874 CCLD patients identified in a nationwide survey, 428 patients born between 1992 and 2012 and treated at 10 high-volume centers, were retrospectively reviewed.RESULTS: Fetal hydrops was visualized using MRI in 9.2 % of the patients. Prenatal interventions were described for 221 of the 428 patients, including the maternal administration of steroid and pleuro-amniotic shunting. Postnatally, a right-to-left shunt flow through a persistent ductus arteriosus was observed in 7.8 % of the patients. The fetal lung lesion volume ratio (LVR) was significantly higher among these symptomatic patients (2.04 ± 1.71 vs. 0.98 ± 0.50, P < 0.00071), and decreased to a greater degree in non-CCAM patients compared with CCAM patients during the late gestational period (from 1.37 ± 1.28 to 1.14 ± 0.84 in CCAM and from 1.08 ± 0.47 to 0.46 ± 0.64 in non-CCAM).CONCLUSIONS: An estimated 8-9 % of prenatally diagnosed patients carry the highest risk of perinatal respiratory distress. Fetal LVR remaining at a high level during the late gestational period seems to predict a high risk.
|
['Abnormalities, Multiple', 'Adult', 'Cystic Adenomatoid Malformation of Lung, Congenital', 'Female', 'Humans', 'Hydrops Fetalis', 'Japan', 'Magnetic Resonance Imaging', 'Male', 'Pregnancy', 'Prenatal Diagnosis', 'Retrospective Studies', 'Ultrasonography, Prenatal']
| 27,461,429
|
[['C16.131.077'], ['M01.060.116'], ['C08.381.150', 'C08.695.290', 'C16.131.740.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.703.277.060.480', 'C15.378.295.480', 'C15.378.420.826.100.350', 'C16.300.060.480', 'C16.320.365.826.100.350', 'C20.306.480', 'C23.888.277.395'], ['Z01.252.474.463', 'Z01.639.595'], ['E01.370.350.825.500'], ['G08.686.784.769'], ['E01.370.378.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['E01.370.350.850.865', 'E01.370.378.630.865']]
|
['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]']
| 0
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 1
|
Activation of gonadotropin-releasing hormone receptors induces a long-term enhancement of excitatory postsynaptic currents mediated by ionotropic glutamate receptors in the rat hippocampus.
|
Whole-cell patch-clamp recordings were made from CA1 pyramidal neurons of the rat hippocampus to study the modulation of gonadotropin-releasing hormone (GnRH) on synaptic transmission mediated by ionotropic glutamate receptors. Leuprolide (10(-9)-10(-7) M), a specific GnRH analog, concentration-dependently elicited a long-lasting potentiation of excitatory postsynaptic currents (EPSCs) mediated by ionotropic glutamate receptors. GnRH receptor-induced synaptic potentiation was blocked by 1 microM [Acetyl-3,4-dehydro-Pro1,D-p-F-Phe2,D-Trp3,6]-LHRH, a specific GnRH receptor antagonist. Furthermore, GnRH receptor-induced synaptic potentiation was associated with the stimulation of protein kinase C (PKC), being considerably attenuated by a potent PKC inhibitor (30 microM H-7). The results suggest a long-term enhanced modulation of GnRH on synaptic transmission mediated by ionotropic glutamate receptors, possibly via the actions of PKC in the hippocampus that is an important integrative system in the regulation of reproductive processes.
|
['Animals', 'Excitatory Postsynaptic Potentials', 'Female', 'Hippocampus', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Kainic Acid', 'Receptors, LHRH']
| 10,027,693
|
[['B01.050'], ['G04.580.887.249', 'G07.265.675.887.249', 'G07.265.880.750.199', 'G11.561.570.918.249', 'G11.561.830.750.199'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D12.776.157.530.400.400.500.200', 'D12.776.543.550.450.500.200.200', 'D12.776.543.585.400.500.200.200', 'D12.776.543.750.720.200.450.400.200'], ['D12.776.543.750.695.410', 'D12.776.543.750.720.600.460', 'D12.776.543.750.750.555.460', 'D12.776.543.750.750.700.460']]
|
['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]']
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
A DNA motif related to the cAMP-responsive element and an exon-located activator protein-2 binding site in the human tissue-type plasminogen activator gene promoter cooperate in basal expression and convey activation by phorbol ester and cAMP.
|
Tissue-type plasminogen activator (t-PA) gene expression is regulated by the tumor-promoting phorbol ester, phorbol-12-myristate 13-acetate (PMA), by cyclic AMP analogues, and the cAMP agonist, forskolin. Based on nuclear "run-on" transcription assays, t-PA expression is modulated by PMA on the level of transcription. 8-Bromo-cyclic AMP and forskolin do not induce t-PA gene transcription alone but act synergistically with PMA. These effects are confirmed by transient expression assays in HeLa cells employing deletion mutants of the t-PA gene promoter fused to the chloramphenicol acetyltransferase (CAT) reporter gene. Constitutive expression and most of the PMA-mediated induction requires sequences downstream of position -145. DNase I protection ("footprint") analysis of this region reveals two protein-binding sites: one between position -102 and -115, differing from the consensus sequence of the cAMP-responsive element (CRE) by the substitution of an adenine for a guanine in the middle of the core motif (TGACATCA), and another, located in the first exon (between position +60 and +74), displaying homology to the consensus sequence of the activator protein 2- (AP-2) binding site (CCCCACCCCC). Base substitutions in the core of either the CRE-like element or the AP-2 site suppress constitutive CAT expression by over 80%, whereas the relative PMA- and PMA plus cAMP-mediated responses are retained. CAT expression is below the detection limit when both elements are mutagenized together. Hence, the CRE-like element and the exon-located AP-2-binding site have a cooperative impact on basal transcription, but each element can independently convey the effect of activators of the protein kinase C- and A-dependent pathways of signal transduction. The results of band-shift analysis and competition titration experiments demonstrate that the CRE-like element acts as a low affinity binding site for the same proteins which recognize the authentic CRE.
|
['Amanitins', 'Base Sequence', 'Binding Sites', 'Cell Line', 'Cloning, Molecular', 'Cyclic AMP', 'Cycloheximide', 'DNA', 'DNA-Binding Proteins', 'Deoxyribonuclease I', 'Exons', 'Gene Expression Regulation, Enzymologic', 'Genes', 'HeLa Cells', 'Humans', 'Molecular Sequence Data', 'Mutation', 'Oligonucleotide Probes', 'Promoter Regions, Genetic', 'RNA, Messenger', 'Templates, Genetic', 'Tetradecanoylphorbol Acetate', 'Tissue Plasminogen Activator', 'Transcription Factor AP-2', 'Transcription Factors', 'Transfection']
| 2,167,321
|
[['D04.345.566.050', 'D12.644.456.050', 'D12.644.641.050', 'D23.946.587.175'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['A11.251.210'], ['E05.393.220'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D03.383.621.808.240'], ['D13.444.308'], ['D12.776.260'], ['D08.811.277.352.335.350.250'], ['G05.360.340.024.340.137.232'], ['G05.308.320'], ['G05.360.340.024.340'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G05.365.590'], ['D13.444.600.601', 'D27.505.259.750.600.650', 'D27.720.470.530.600.650'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D13.444.735.544'], ['G05.360.840'], ['D02.455.849.291.500.510.850'], ['D08.811.277.656.300.760.875', 'D08.811.277.656.959.350.875', 'D12.776.124.125.662.768', 'D23.119.970'], ['D12.776.260.760', 'D12.776.930.907'], ['D12.776.930'], ['E05.393.350.810', 'G05.728.860']]
|
['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 1
| 0
| 0
| 0
|
Characterization of tuberculous lesions in naturally infected African buffalo (Syncerus caffer).
|
Tuberculosis pathology was studied on 19 African buffalo (Syncerus caffer) from a herd in the Hluhluwe-iMfolozi Park in South Africa. The animals tested positive with the comparative intradermal tuberculin test and were euthanized during a test-and-cull operation to decrease prevalence of bovine tuberculosis (bTB) in the park. The lymph nodes and lungs were examined grossly for presence of tuberculous lesions, which were scored on a 0-5 scale for macroscopic changes. The gross lesions were examined histologically and classified into grade I, II, III, or IV according to a grading system used for bTB lesions in domestic cattle. Macroscopic lesions were limited to the retropharyngeal, bronchial, and mediastinal lymph nodes and the lungs. The most frequently affected lymph nodes were the bronchial (in 16 animals) and mediastinal (in 11 animals). All four grades of microscopic lesions were observed, grade II lesions were the most frequent. Mycobacterium bovis was detected by PCR in 8 out of 19 animals, and acid-fast bacilli were seen in 7 out of 19 animals, together both techniques identified mycobacteria in 5 out of 19 animals. Lesions were paucibacillary, as acid-fast bacilli were only rarely observed. The absence of lesions in the mesenteric lymph nodes and the high frequency of lesions in respiratory tract associated lymph nodes suggest that the main route of M. bovis infection in African buffalo is by inhalation.
|
['Animals', 'Buffaloes', 'Female', 'Lung', 'Lymph Nodes', 'Male', 'Mycobacterium bovis', 'South Africa', 'Tuberculin Test', 'Tuberculosis']
| 21,908,368
|
[['B01.050'], ['B01.050.150.900.649.313.500.380.135'], ['A04.411'], ['A10.549.400', 'A15.382.520.604.412'], ['B03.510.024.962.500.402', 'B03.510.460.400.410.552.552.402'], ['Z01.058.290.175.735'], ['E01.370.225.812.871.800', 'E05.200.812.871.800', 'E05.478.594.890.800'], ['C01.150.252.410.040.552.846']]
|
['Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 1
|
Determination of patulin by capillary gas chromatography of the heptafluorobutyrate derivative.
|
Formation and capillary gas chromatography of patulin heptafluorobutyrate is reported for the first time. The derivative was identified by gas chromatography-mass spectrometry (M+ = 350). Electron-capture detector response for patulin heptafluorobutyrate was linear in the range 0.05 to 0.5 ng. This sensitive and reproducible derivatization technique was applied to the determination of patulin in apple juice by capillary gas chromatography-electron-capture detection. The overall method recovery averaged 84% and less than or equal to 10 micrograms/l could be detected.
|
['Beverages', 'Chromatography, Gas', 'Food Contamination', 'Fruit', 'Gas Chromatography-Mass Spectrometry', 'Patulin']
| 2,016,387
|
[['G07.203.100', 'J02.200'], ['E05.196.181.349'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['E05.196.181.349.500', 'E05.196.566.500'], ['D03.383.663.663', 'D23.946.587.725']]
|
['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]']
| 1
| 0
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 0
|
[Treatment of fresh humeral diaphysis fractures by Seidel intramedullary locked nailing. A study of 23 initial cases after 2.5 years with rotator cuff evaluation].
|
PURPOSE OF THE STUDY: The Seidel intramedullary locking nail is one of the alternative methods for operative treatment of humeral shaft fractures. Short follow-up demonstrated persistent pain and stiffness at the shoulder joint. The aims of this retrospective study were first to evaluate results with attention to operative technique, consolidation rate and postoperative complications. Second we studied rotator cuff healing in our first patients.MATERIAL AND METHODS: Twenty-five acute diaphyseal fractures were treated between May 91 and Dec 94. We reviewed personally 23 patients with a mean follow-up of 33 months (range 22-66). The dominant fracture type according to AO was type A. Clinical shoulder assessment was carried out using the Constant score. Isometric strength was recorded in both shoulders with a hand-held dynamometer in abduction, external and internal rotation. Sonographic evaluation of the rotator cuff was performed using a 7.5 MHz linear array transducer in all 23 patients.RESULTS: All but one fracture healed at an average of two months. Impingement was observed in three patients but pain relief and normal shoulder motion have been reached after nail removal. Infection occurred in one patient but final result was good. Constant score averaged 78.7 (range 51-94.2) classifying the result in all but two patients as excellent or good. Compared with the external and internal rotations, strength was significantly reduced in abduction but reached 83.5 per cent of the opposite shoulder. No statistical differences were found in relation with age, gender and side. Compared with the contralateral shoulder, rotator cuff evaluation with sonography was considered as normal in 18 patients. Calcium deposits of the cuff were noticed in the infected patient. In three cases sonography detected hyperechoic line considered as scar in the supraspinatus tendon without any partial or full-thickness tear.DISCUSSION AND CONCLUSION: A median starting point avoids the avascular area and gives a straight access to the medullary canal. This study demonstrates that using this entry portal and a reliable technique antegrade nailing of the humerus does not compromise rotator cuff healing and shoulder function. Technical errors lead to poor or fair results but despite this learning curve, Seidel nail when operative treatment is indicated, is a good choice. Attention must be paid to patients with clinical history of impingement or rotator cuff tendinopathy.
|
['Adult', 'Aged', 'Aged, 80 and over', 'Data Interpretation, Statistical', 'Female', 'Follow-Up Studies', 'Fracture Fixation, Intramedullary', 'Humans', 'Humeral Fractures', 'Male', 'Middle Aged', 'Rotator Cuff', 'Time Factors']
| 10,457,553
|
[['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E04.555.300.300.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.088.390', 'C26.404.500'], ['M01.060.116.630'], ['A02.633.567.912', 'A02.880.700'], ['G01.910.857']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]']
| 1
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 1
| 1
| 1
| 0
|
Protective effect of pioglitazone on cardiomyocyte apoptosis in low-dose streptozotocin & high-fat diet-induced type-2 diabetes in rats.
|
BACKGROUND & OBJECTIVES: Cardiomyocyte apoptosis is one of the pathologic phenomena associated with diabetes and related conditions including obesity, insulin resistance and hyperlipidaemia. In the present study, the protective effects of pioglitazone on cardiomyocyte apoptosis was evaluated in experimental diabetes induced by low dose of streptozoticin (STZ) combined with high fat diet (HFD) in rats.METHODS: Male Wistar rats (150-200 g) were injected with low-dose STZ (45 mg/kg, i.v., single dose) and orally fed with a HFD (20 g/day/rat) for a period of 28 days and simultaneously treated with pioglitazone (20 mg/kg/p.o.) for a period of 21 days (from 8 th day to 28 th day). On 29 th day blood was collected, serum separated and used for biochemical parameters. Heart tissue was used for cardiomyocyte apoptosis measurement and also for histopathological examination.RESULTS: Pioglitazone treatment resulted in a decrease in cardiomyocyte apoptosis as revealed by a decrease in cardiac caspase-3, lactate dehydrogenase (LDH) levels and DNA fragmentation, and an increase in Na+K+ATPase levels in diabetic rats. Cardiac histology of diabetic control rats showed dense focal fatty infiltration in the myocardial cells whereas normal architecture with regular morphology and well preserved cytoplasm was observed with pioglitazone treatment. Pioglitazone treatment significantly reduced the heart rate, mean arterial blood pressure, body mass index (BMI) and levels of serum glucose, leptin, insulin, HOMA-IR, total cholesterol (TC) and triglycerides (TGs), apoliproprotein-B glycosylated haemoglobin (HbA1c) levels and atherogenic index, and increased the levels of serum high density lipoprotein cholesterol (HDL-C) and cardiac antioxidant enzymes.INTERPRETATION & CONCLUSIONS: The present study results suggest that pioglitazone possesses cardiac anti-apoptotic potential in diabetic rat model and can be further explored for its use for treatment of diabetic cardiomyopathy.
|
['Animals', 'Apoptosis', 'Diabetes Mellitus, Type 2', 'Diet, High-Fat', 'Hypoglycemic Agents', 'Male', 'Myocytes, Cardiac', 'Pioglitazone', 'Rats', 'Rats, Wistar', 'Streptozocin', 'Thiazolidinediones']
| 26,658,596
|
[['B01.050'], ['G04.146.954.035'], ['C18.452.394.750.149', 'C19.246.300'], ['G07.203.650.240.267'], ['D27.505.696.422'], ['A07.541.704.570', 'A10.690.552.750.570', 'A11.620.500'], ['D02.886.675.933.250', 'D03.383.129.708.933.250'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D02.065.950.594.768', 'D02.654.692.768', 'D09.408.051.900'], ['D02.886.675.933', 'D03.383.129.708.933']]
|
['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]']
| 1
| 1
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.
|
The British Regional Heart Study (BRHS) reported in 1986 that much of the inverse relation of high-density lipoprotein cholesterol (HDLC) and incidence of coronary heart disease was eliminated by covariance adjustment. Using the proportional hazards model and adjusting for age, blood pressure, smoking, body mass index, and low-density lipoprotein cholesterol, we analyzed this relation separately in the Framingham Heart Study (FHS), Lipid Research Clinics Prevalence Mortality Follow-up Study (LRCF) and Coronary Primary Prevention Trial (CPPT), and Multiple Risk Factor Intervention Trial (MRFIT). In CPPT and MRFIT (both randomized trials in middle-age high-risk men), only the control groups were analyzed. A 1-mg/dl (0.026 mM) increment in HDLC was associated with a significant coronary heart disease risk decrement of 2% in men (FHS, CPPT, and MRFIT) and 3% in women (FHS). In LRCF, where only fatal outcomes were documented, a 1-mg/dl increment in HDLC was associated with significant 3.7% (men) and 4.7% (women) decrements in cardiovascular disease mortality rates. The 95% confidence intervals for these decrements in coronary heart and cardiovascular disease risk in the four studies overlapped considerably, and all contained the range 1.9-2.9%. HDLC levels were essentially unrelated to non-cardiovascular disease mortality. When differences in analytic methodology were eliminated, a consistent inverse relation of HDLC levels and coronary heart disease event rates was apparent in BRHS as well as in the four American studies.
|
['Adult', 'Aged', 'Cardiovascular Diseases', 'Cholesterol, HDL', 'Clinical Trials as Topic', 'Cohort Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Regression Analysis', 'Risk Factors', 'Sex Factors', 'Statistics as Topic']
| 2,642,759
|
[['M01.060.116'], ['M01.060.116.100'], ['C14'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725'], ['N05.715.350.675', 'N06.850.490.875'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.850.520.830']]
|
['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]']
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 1
| 1
| 0
|
Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging.
|
Nanoparticle uptake and distribution to solid tumors are limited by reticuloendothelial system systemic filtering and transport limitations induced by irregular intra-tumoral vascularization. Although vascular enhanced permeability and retention can aid targeting, high interstitial fluid pressure and dense extracellular matrix may hinder local penetration. Extravascular diffusivity depends upon nanoparticle size, surface modifications, and tissue vascularization. Gold nanoparticles functionalized with biologically-compatible layers may achieve improved uptake and distribution while enabling cytotoxicity through synergistic combination of chemotherapy and thermal ablation. Evaluation of nanoparticle uptake in vivo remains difficult, as detection methods are limited. We employ hyperspectral imaging of histology sections to analyze uptake and distribution of phosphatidylcholine-coated citrate gold nanoparticles (CGN) and silica-gold nanoshells (SGN) after tail-vein injection in mice bearing orthotopic pancreatic adenocarcinoma. For CGN, the liver and tumor showed 26.5 ± 8.2 and 23.3 ± 4.1 particles/100 ìm2 within 10 ìm from the nearest source and few nanoparticles beyond 50 ìm, respectively. The spleen had 35.5 ± 9.3 particles/100 ìm2 within 10 ìm with penetration also limited to 50 ìm. For SGN, the liver showed 31.1 ± 4.1 particles/100 ìm2 within 10 ìm of the nearest source with penetration hindered beyond 30 ìm. The spleen and tumor showed uptake of 22.1 ± 6.2 and 15.8 ± 6.1 particles/100 ìm2 within 10 ìm, respectively, with penetration similarly hindered. CGH average concentration (nanoparticles/ìm2) was 1.09 ± 0.14 in the liver, 0.74 ± 0.12 in the spleen, and 0.43 ± 0.07 in the tumor. SGN average concentration (nanoparticles/ìm2) was 0.43 ± 0.07 in the liver, 0.30 ± 0.06 in the spleen, and 0.20 ± 0.04 in the tumor. Hyperspectral imaging of histology sections enables analysis of phosphatidylcholine-coated gold-based nanoparticles in pancreatic tumors with the goal to improve nanotherapeutic efficacy.
|
['Adenocarcinoma', 'Animals', 'Cell Line, Tumor', 'Drug Delivery Systems', 'Female', 'Gold', 'Humans', 'Liver', 'Metal Nanoparticles', 'Mice, SCID', 'Nanoshells', 'Pancreatic Neoplasms', 'Particle Size', 'Phosphatidylcholines', 'Silicon Dioxide', 'Spectrophotometry', 'Spleen', 'Tissue Distribution', 'Transplantation, Heterologous']
| 26,046,360
|
[['C04.557.470.200.025'], ['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['E02.319.300'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['J01.637.512.600.500'], ['B01.050.150.900.649.313.992.635.505.500.550.780'], ['J01.637.512.600.500.575'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19.344.421'], ['G02.712'], ['D10.570.755.375.760.400.800'], ['D01.578.750', 'D01.650.550.825', 'D01.837.725'], ['E05.196.712.726', 'E05.196.867.826'], ['A10.549.700', 'A15.382.520.604.700'], ['G03.787.917', 'G07.690.725.949'], ['E04.936.764']]
|
['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
|
Peer victimization, cue interpretation, and internalizing symptoms: preliminary concurrent and longitudinal findings for children and adolescents.
|
This study examined hostile intent and causal, critical self-referent attributions for ambiguous peer cues to examine the hypothesis that these latter interpretations would be uniquely associated with symptoms of depression, social anxiety, and loneliness. Critical self-referent attributions were assessed in 116 kindergarteners (Study 1) and 159 adolescents (Study 2) using a hypothetical vignette procedure, replicating past work on social information processing. In both samples, critical self-referent attributions were concurrently associated with depressive symptoms as reported by teacher (Study 1), peer, and self-report (Study 2). Critical self-referent attributions also were concurrently associated with loneliness and with actual peer experiences, including peer rejection in both studies. Results from both studies support a cognitive vulnerability-stress model, suggesting that the tendency to derive critical self-referent attributions from ambiguous peer experiences is most closely associated with depressive symptoms when accompanied by high levels of peer victimization. Longitudinal findings (Study 2) offers preliminary evidence for this cognitive vulnerability-stress model as a predictor of adolescents' depressive symptoms over a 17-month interval.
|
['Adolescent', 'Child', 'Child, Preschool', 'Cognition', 'Crime Victims', 'Depression', 'Female', 'Hostility', 'Humans', 'Loneliness', 'Longitudinal Studies', 'Male', 'Peer Group', 'Phobic Disorders', 'Self Concept', 'Stress, Psychological']
| 15,677,277
|
[['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['F02.463.188'], ['M01.135'], ['F01.145.126.350'], ['F01.470.596'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.470.713', 'I01.880.853.748.435'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['F01.829.316.483'], ['F03.080.725'], ['F01.752.747.792'], ['F01.145.126.990', 'F02.830.900']]
|
['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]']
| 0
| 1
| 0
| 0
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 1
| 0
|
Understanding the effects of PBF process parameter interplay on Ti-6Al-4V surface properties.
|
Ti-6Al-4V is commonly used in orthopaedic implants, and fabrication techniques such as Powder Bed Fusion (PBF) are becoming increasingly popular for the net-shape production of such implants, as PBF allows for complex customisation and minimal material wastage. Present research into PBF fabricated Ti-6Al-4V focuses on new design strategies (e.g. designing pores, struts or lattices) or mechanical property optimisation through process parameter control-however, it is pertinent to examine the effects of altering PBF process parameters on properties relating to bioactivity. Herein, changes in Ti-6Al-4V microstructure, mechanical properties and surface characteristics were examined as a result of varying PBF process parameters, with a view to understanding how to tune Ti-6Al-4V bio-activity during the fabrication stage itself. The interplay between various PBF laser scan speeds and laser powers influenced Ti-6Al-4V hardness, porosity, roughness and corrosion resistance, in a manner not clearly described by the commonly used volumetric energy density (VED) design variable. Key findings indicate that the relationships between PBF process parameters and ultimate Ti-6Al-4V properties are not straightforward as expected, and that wide ranges of porosity (0.03 ± 0.01% to 32.59 ± 2.72%) and corrosion resistance can be achieved through relatively minor changes in process parameters used-indicating volumetric energy density is a poor predictor of PBF Ti-6Al-4V properties. While variations in electrochemical behaviour with respect to the process parameters used in the PBF fabrication of Ti-6Al-4V have previously been reported, this study presents data regarding important surface characteristics over a large process window, reflecting the full capabilities of current PBF machinery.
|
['Corrosion', 'Hardness', 'Implants, Experimental', 'Porosity', 'Titanium']
| 31,465,449
|
[['G02.165'], ['G01.374.647'], ['E07.695.340'], ['G01.374.710'], ['D01.268.557.800', 'D01.268.956.878', 'D01.552.547.800']]
|
['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]']
| 0
| 0
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Maternal education and adverse birth outcomes among immigrant women to the United States from Eastern Europe: a test of the healthy migrant hypothesis.
|
Immigrant women to the U.S. often have more favorable birth outcomes than their native-born counterparts, including lower rates of preterm birth and low birth weight, a phenomenon commonly attributed to a healthy migrant effect. However, this effect varies by ethnicity and country of origin. No previous study has examined birth outcomes among immigrants from the post-Communist countries of Eastern Europe, a group which includes both economic migrants and conflict refugees. Using data on 253,363 singletons births from New York City during 1995-2003 we examined the risk of preterm birth (PTB) (<37 weeks) or delivering a term small-for-gestational-age (SGA) infant among immigrants from Russia and Ukraine (RU), Poland, and former Yugoslavia Republics (FYR) relative to US-born non-Hispanic whites (NHW). Women in all three Eastern European groups had significantly later entry into prenatal care, were more likely to be Medicaid recipients, and had lower educational attainment than US-born NHW. In binomial regression analyses adjusting for age, education, parity, and pre-pregnancy weight, women from RU and FYR had lower risk of PTB than US-born NHW, whereas women from Poland had similar risk. Lower SGA risk was found among women from Poland and FYR, but not RU. When stratified by education, women with <12 years of education from all Eastern European groups had a reduced risk of PTB relative to US-born NHW. An educational gradient in PTB and SGA risk was less pronounced in all Eastern European groups compared to US-born NHW. The healthy migrant effect is present among immigrants from Eastern Europe to the U.S., especially among women with less education and those from the former Yugoslavia, a group that included many conflict refugees.
|
['Adult', 'Educational Status', 'Emigrants and Immigrants', 'European Continental Ancestry Group', 'Female', 'Health Status Disparities', 'Humans', 'Infant, Newborn', 'Infant, Small for Gestational Age', 'Mothers', 'New York City', 'Poland', 'Pregnancy', 'Premature Birth', 'Republic of North Macedonia', 'Risk', 'Russia', 'Ukraine', 'Young Adult']
| 21,724,312
|
[['M01.060.116'], ['N01.824.196'], ['M01.189'], ['M01.686.508.400'], ['I01.240.425.675', 'N01.224.425.437', 'N06.850.505.400.425.675'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.460.560'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['Z01.107.567.875.350.530.530', 'Z01.107.567.875.500.530.530', 'Z01.433.741'], ['Z01.542.248.679'], ['G08.686.784.769'], ['C13.703.420.491.500'], ['Z01.542.248.517'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700', 'N06.850.520.830.600.800'], ['Z01.252.122.500', 'Z01.542.248.775'], ['Z01.542.248.960', 'Z01.542.931.960', 'Z01.586.950.960'], ['M01.060.116.815']]
|
['Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 0
| 1
| 1
| 0
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 1
| 1
|
Anterior region of the atrioventricular perinodal area in relation to radiofrequency ablation procedures.
|
Atrioventricular nodal reentry tachycardia base on reentry circulation in nodal-perinodal area. The radical treatment of choice is radiofrequency ablation. Procedure approached from the anterior-superior (fast) region sufficient a few seconds of energy delivery for success, however this can result in A-V block. The possibility that arrhythmias substrate may lie very superficially (success of ablation) and damage the normal structures (complication) in the perinodal region must be considered. In order to confirm this hypothesis we examined the autopsy material of 100 normal hearts, both sexes from 18 to 105 years of age (control) and 50 hearts with A-V total block 45-95 years of age (block). We paid attention to the morphology of the nodal artery (NA), atrial inputs (AI) and transitional inputs (TI). It was observed that NA at the level of the central fibrous body was positioned in 94% in the central and in 6% in the inferior part of Koch's triangle. It was removed from the endocardium 3-6 mm in control and 2-5 mm in block group respectively (NS). In the perinodal area we distinguished AI that directly joined the A-V compact node: superficial (right part of the interatrial septum) or deep (left part). The former occurred in 100% of controls and in 80% of block groups (NS), and the latter in 80% of control group and in 34% in block respectively (p < 0.05). The real substrate of arrhythmia in anterior-superior region lies very superficially and far from the conduction tissue; NA in examined hearts was lying deep beneath the endocardium; ablation close to the node could result in A-V block.
|
['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Atrioventricular Node', 'Catheter Ablation', 'Female', 'Heart', 'Histocytochemistry', 'Humans', 'Male', 'Middle Aged', 'Tachycardia, Atrioventricular Nodal Reentry']
| 11,770,341
|
[['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.541.409.147'], ['E02.808.750.500', 'E04.014.760.500'], ['A07.541'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.067.845.787.249', 'C14.280.123.875.787.249', 'C23.550.073.845.787.500']]
|
['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 1
| 0
| 0
|
[Measurement of gamma-interferon in sera and CSF in patients with multiple sclerosis and inflammatory neurological diseases].
|
We examined whether gamma-interferon (gamma-IFN) can be detected in serum and CSF of patients with multiple sclerosis and other inflammatory neurological diseases. Gamma-IFN was assayed by solid phase radioimmunoassay on the forward sandwich principle. In 7 serum samples in acute stage of multiple sclerosis without corticosteroid, in 2 CSF samples in acute stage, gamma-IFN was not detected. In stable stage there was no case with positive gamma-IFN. The patient with tuberculous meningitis showed high titer in CSF but not in serum. One case with herpes zoster meningitis, one case out of 2 aseptic encephalitis showed positive gamma-IFN in CSF. In one case with Vogt-Koyanagi-Harada disease, gamma-IFN was detected both in serum and CSF. One case with Neuro-Beh?et syndrome showed positive gamma-IFN in CSF. No gamma-IFN was detected in 2 cases with Guillain-Barr? syndrome, one case with Crow-Fukase syndrome, Fisher syndrome, 2 cases with polymyosits. gamma-IFN in CSF was detected in meningitis and encephalitis, but not in serum. This suggests that the locally infiltrating cells produce gamma-IFN. However, we could not detect gamma-IFN in either CSF or serum of patients with multiple sclerosis. Negative results of gamma-IFN in patients with multiple sclerosis can be interpreted in 2 ways. 1. The half life of gamma-IFN is very short in vivo, and the level of gamma-IFN may not be detected at the time of sampling. 2. Generalized augmentation of gamma-IFN production may not be observed but locally infiltrating cells or astrocytes might produce gamma-IFN.(ABSTRACT TRUNCATED AT 250 WORDS)
|
['Behcet Syndrome', 'Humans', 'Interferon-gamma', 'Multiple Sclerosis', 'Polyradiculoneuropathy']
| 2,119,268
|
[['C07.465.075', 'C11.941.879.780.880.200', 'C14.907.940.100', 'C16.320.382.250', 'C17.800.827.368.250', 'C17.800.862.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893', 'D23.529.374.480.615.350'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['C10.114.750', 'C10.314.750', 'C10.668.829.800.750', 'C20.111.258.750']]
|
['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]']
| 0
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Phase II trial of Serratia marcescens extract in recurrent malignant astrocytoma.
|
Nineteen assessable patients with recurrent malignant astrocytomas who had failed standard therapy (surgery, radiation, and/or chemotherapy) were treated on a phase I-II trial with a biologic extract of Serratia marcescens (ImuVert; Cell Technology, Boulder, CO) a new biologic response modifier (BRM). Two complete responses (CRs) were seen, of 63 and 77+ weeks duration. One minor response (MR) occurred, of 6 weeks duration. There were four additional stable (S) patients, with durations of 58+, 39, 12, and 7 weeks. Median time to progression and median survival in the CR plus MR patients were 63 and 129+ weeks, respectively. Overall, median time to progression and median survival were 12 and 19 weeks, respectively. Three patients are alive greater than or equal to 2.5 years from study entry. Common toxicities included transient (less than 72 hours) tenderness, induration, and erythema at the injection sites. Systemic toxicities were less frequent and included fever, chills, nausea/vomiting, headache, arthralgia, and hypotension. The response rate (CR plus MR) to this new BRM is modest (16%). However, the observation of CRs in patients with advanced recurrent malignant astrocytomas, with acceptable overall toxicity, warrants further study of this agent.
|
['Adult', 'Aged', 'Antineoplastic Agents', 'Astrocytoma', 'Biological Products', 'Brain Neoplasms', 'Drug Evaluation', 'Female', 'Fever', 'Humans', 'Immunologic Factors', 'Male', 'Middle Aged', 'Nausea', 'Neoplasm Recurrence, Local', 'Remission Induction', 'Serratia marcescens', 'Survival Rate', 'Vomiting']
| 2,199,624
|
[['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['C04.557.465.625.600.380.080', 'C04.557.470.670.380.080', 'C04.557.580.625.600.380.080'], ['D20.215'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E05.290.625', 'E05.337.425'], ['C23.888.119.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477'], ['M01.060.116.630'], ['C23.888.821.712'], ['C04.697.655', 'C23.550.727.655'], ['E02.860'], ['B03.440.450.425.814.664', 'B03.660.250.150.720.500'], ['E05.318.308.985.550.900', 'N01.224.935.698.826', 'N06.850.505.400.975.550.900', 'N06.850.520.308.985.550.900'], ['C23.888.821.937']]
|
['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]']
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Perceptions of urinary symptoms and health-care-seeking behaviour amongst men aged 40-79 years.
|
BACKGROUND: Little is known about why men fail to seek medical help for urological symptoms.AIM: This study was designed to document men's perceptions of urinary symptoms and to increase understanding of health-care-seeking behaviour.METHOD: A stratified random sample of men aged 40-79 years was drawn from the age-sex register of a health centre in Central Scotland. Two hundred men were interviewed using semi-structured qualitative techniques and asked to complete a symptom questionnaire. The response rate was 65%.RESULTS: Urinary symptoms reported to be most bothersome were dribbling, hesitancy and straining. All but the youngest age group (40-49 years) associated developing urinary symptoms with ageing. This was considered to be a reason not to consult a doctor. Most symptoms were not thought to be serious. Pain, haematuria and acute retention gave cause for concern, and were perceived as reasons for seeking medical help. Although urinary symptoms interfered with selected activities in daily life, this was not a worry to the men and was not seen to be a sufficient reason alone to consult their general practitioner.CONCLUSION: The insidious development of urinary problems over time reinforces the belief that it is part of getting older and accounts for the accommodation of symptoms within men's everyday living experiences. Bothersomeness associated with urinary symptoms was not synonymous with worry or problems. Doctors must be prepared to initiate discussion about urinary function in order to assess the impact of symptoms on an individual's daily life.
|
['Adult', 'Age Factors', 'Aged', 'Attitude to Health', 'Humans', 'Male', 'Middle Aged', 'Patient Acceptance of Health Care', 'Perception', 'Urination Disorders']
| 8,983,253
|
[['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['F01.100.150', 'N05.300.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.100.150.750.500', 'F01.145.488.887.500', 'N05.300.150.800.500'], ['F02.463.593'], ['C12.777.934', 'C13.351.968.934']]
|
['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]']
| 0
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Endoscopic resection of ampullary adenomas: complications and outcomes.
|
AIM: Ampullary adenomas have the potential to progress from benign to malignant lesions. Endoscopic ampullectomy as curative therapy has gained credibility as a safe and effective alternative to surgical resection. This study was designed to assess outcomes of endoscopic resection of ampullary neoplasms at a single center.METHODS: Between May 1996 and August 2009, all patients referred to our center for endoscopic resection of an ampullary lesion were retrospectively identified. Patients were followed for complications and endoscopic surveillance performed per protocol to assess for recurrence.RESULTS: Endoscopic ampullectomy for adenoma was performed in 38 patients (22 females; mean age, 54.3 years, range, 22-85 years), with high-grade dysplasia (HGD) diagnosed in 6 and low-grade dysplasia (LGD) in 32. A direct relationship was observed between HGD and tumor size (P = 0.03). Lesions less than 2.5 cm in size demonstrated no evidence of invasion. Mean follow-up duration was 17.2 ± 2 months (range, 0-82.5 months). Complications were uniformly mild and occurred in 6 (16%) patients: bleeding in 2, pancreatitis in 3, and infection in 1. Adenoma recurrence was documented in 6 (16%) patients, 4 with LGD and 2 with HGD; no patients had tumors that progressed from LGD to HGD or HGD to cancer. Kaplan-Meier analysis showed insignificant differences in recurrence between HGD and LGD groups (P = 0.13).CONCLUSIONS: Endoscopic ampullectomy is a safe and effective treatment for benign ampullary neoplasms and should become the treatment of choice rather than surgical therapy.
|
['Adenoma', 'Adult', 'Aged', 'Aged, 80 and over', 'Ampulla of Vater', 'Common Bile Duct Neoplasms', 'Endoscopy, Gastrointestinal', 'Female', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Treatment Outcome', 'Young Adult']
| 21,761,167
|
[['C04.557.470.035'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A03.159.183.079.300.950', 'A03.556.124.684.124.236', 'A03.556.875.249.160', 'A03.734.667.500'], ['C04.588.274.120.250.250', 'C06.130.120.120.280', 'C06.130.120.250.280', 'C06.130.320.120.280', 'C06.301.120.250.250'], ['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04.210.240.250', 'E04.502.250.250.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['M01.060.116.815']]
|
['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
miR-146b level and variants is associated with endometriosis related macrophages phenotype and plays a pivotal role in the endometriotic pain symptom.
|
OBJECTIVE: The aim of this study was to explore the effect of miR-146b expression and variants on endometriosis and its associated pain symptom.MATERIALS AND METHODS: Genotyping and expression of miR-146b was performed on 74 endometriosis patients and 23 healthy controls. ESCs were subsequently co-cultured with peripheral blood (PB)-derived monocytes (PBMC)-driven macrophages. After overexpression and inhibition of miR-146b, cytokine production from the macrophages were determined by enzyme-linked immunosorbent assay (ELISA). Western blot were done to measure the regulation of IRF5 by miR-146b.RESULTS: We found that miR-146b expression was increased in PF supernatant and PF CD14 + monocytes/Macrophages of endometriosis patients, with endometriosis patients with pain (EPWP) showing higher miR-146b expression compared with the endometriosis patients without pain (EPNP). CT/CC genotype of miR-146b rs1536309 was associated with the risk of pain symptom of endometriosis. For the function studies, we found that miR-146b was involved in the negative regulation of inflammation through attenuating IRF5 expression. Macrophages from patients who carries CT/CC genotype of miR-146b rs1536309 showed decreasing miR-146b expression and enhancement of the ability of pro-inflammation.CONCLUSIONS: Our findings suggest an important role of miR-146b level and variants in endometriosis that helps to regulate the process of endometriosis and its associated pain.
|
['Adult', 'Case-Control Studies', 'Endometriosis', 'Female', 'Humans', 'Interferon Regulatory Factors', 'Macrophages', 'MicroRNAs', 'Pain', 'Stromal Cells', 'Surveys and Questionnaires']
| 31,122,533
|
[['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C13.351.500.163'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360.024.302', 'D12.776.157.057.050', 'D12.776.260.504', 'D12.776.476.024.385', 'D12.776.930.332'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['A11.329.830'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]']
| 1
| 1
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
An analysis of India's 2017 National Ethical Guidelines for Biomedical and Health Research Involving Human Participants: The Social and Behavioural Sciences aspect.
|
In this commentary on Section 9 (Social and Behavioural Sciences Research for Health) of the National Ethical Guidelines for Biomedical and Health Research Involving Human Participants (2017) by the Indian Council of Medical Research (ICMR), we appreciate that the guidelines clarify that human beings are "research participants" and not merely "subjects". Further, we appreciate and commend the ICMR for: i) contextualising the guidelines to India's unique sociocultural and economic situation and ii) affirming the multidisciplinary nature of health research and the wide scope of social and behavioural research. However, we question the prominence given to the difference between biomedical research and other aspects of health research and the description of social and psychological risks and discomforts as minor risks. Finally, we suggest that the guidelines would express greater value and diversity of the social aspects of health if they recommended wider representation of these aspects in the composition of research ethics committees.
|
['Behavioral Sciences', 'Biomedical Research', 'Ethical Review', 'Ethics Committees, Research', 'Ethics, Research', 'Guidelines as Topic', 'Human Experimentation', 'Humans', 'India', 'Organizations', 'Research Subjects', 'Risk', 'Social Sciences', 'Socioeconomic Factors']
| 30,211,676
|
[['F04.096'], ['H01.770.644.145'], ['K01.752.566.479.117', 'N05.350.250'], ['K01.752.566.479.147.750', 'N04.452.758.788.300.750', 'N05.350.268.750', 'N05.700.685.300.750'], ['K01.752.566.479.173', 'N05.350.670'], ['N04.761.700.350', 'N05.700.350'], ['E05.445', 'H01.770.644.145.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['N03.540'], ['M01.774'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700', 'N06.850.520.830.600.800'], ['F04.096.879', 'I01'], ['I01.880.853.996', 'N01.824']]
|
['Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Humanities [K]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]']
| 0
| 1
| 0
| 0
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 1
| 1
| 1
|
Validation of the accuracy of the perturbation peak method for determination of single and binary adsorption isotherm parameters in LC.
|
An analytical validation of the precision and accuracy of the perturbation peak (PP) method for determination of single and competitive thermodynamic isotherm parameters was performed using frontal analysis as a reference. The isotherm parameters of 11alpha-hydroxyprogesterone were determined in an achiral system and the isotherm parameters of (+)-methyl L-mandelate and (-)-methyl D-mandelate were determined in a chiral system, both for the single components and for the competitive binary mixture. The experimental errors in the PP method using different injection techniques were investigated, and we devised a new injection technique for the determination of competitive isotherm parameters that considerably reduced the experimental errors and also made both perturbation peaks detectable. We showed that the PP method with the new injection technique can be used to determine isotherm parameters directly from a racemic mixture. These parameters agreed well with those determined using several enantiomer ratios. Elution-band profiles simulated using the isotherm parameters showed excellent agreement with experimental profiles.
|
['Chromatography, Liquid', 'Hydroxyprogesterones', 'Models, Theoretical', 'Reproducibility of Results', 'Thermodynamics']
| 15,307,798
|
[['E05.196.181.400'], ['D04.210.500.745.745.654.829.395', 'D06.472.334.851.687.750.478'], ['E05.599'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['G01.906']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]']
| 0
| 0
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 0
|
Efficacy of electrohydraulic lithotripsy in the ureter.
|
Since January of 1983, 62 patients with ureteral calculi had their stones fragmented with electrohydraulic lithotripsy via an antegrade approach percutaneously or retrograde approach ureteroscopically. Success was achieved in 97% of these cases, with insignificant ureteral perforations noted in eight. Follow-up via intravenous pyelograms obtained in 60 patients revealed no significant persistent hydronephrosis. It appears, therefore, that the use of electrohydraulic lithotripsy in the ureter utilized with direct vision endoscopes is safe, efficacious and relatively inexpensive.
|
['Endoscopes', 'Endoscopy', 'Equipment Safety', 'Humans', 'Lithotripsy', 'Ureter', 'Ureteral Calculi']
| 10,148,925
|
[['E07.230.220', 'E07.858.240'], ['E01.370.388.250', 'E04.502.250'], ['E05.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.600', 'E04.943.500'], ['A05.810.776'], ['C12.777.725.938.500', 'C12.777.967.374.500', 'C12.777.967.500.851', 'C13.351.968.725.938.500', 'C13.351.968.967.374.500', 'C13.351.968.967.500.851', 'C23.300.175.850.750']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Effect of diet phase change, dietary Ca and P level and phytase on bird performance and real-time gizzard pH measurements.
|
In this study, a novel capsule technique was used to capture real-time pH readings from the gizzard over several hours, in response to different dietary treatments. 1. The first experiment was a preliminary study into capsule administration and pH recordings using 9 male Ross 308 broilers from 20 d. In the second experiment, broilers (576) were fed in two phases (0-21 and 21-42 d) with 4 treatment groups; low and adequate Ca and AvP diets with and without Quantum Blue phytase (1500 FTU/kg). Capsules were administered to 8 birds from each treatment group, pre and post diet phase change, with readings captured over a 2.5 h period. 2. Phytase addition improved body weight gain (BWG) and feed conversion ratio (FCR) of birds fed low dietary Ca, while having no significant effect on birds fed adequate Ca diets. Unexpectantly, diets with higher Ca levels gave a lower average gizzard pH compared to the low Ca diet. Phytase addition, irrespective of Ca level, increased average gizzard pH. Fluctuations in gizzard pH (0.6-3.8) were observed across all treatment groups. Higher frequencies of pH readings below pH 1.0 were seen in birds fed an adequate Ca diet and with phytase supplementation of a low Ca diet. 3. These results signify the potential use of capsule techniques to monitor real-time pH changes. The implication on gastric protein and fibre hydrolysis as a result of large fluctuations in pH should be considered.
|
['6-Phytase', 'Animal Feed', 'Animal Husbandry', 'Animals', 'Calcium, Dietary', 'Chickens', 'Dermatitis', 'Diet', 'Dietary Supplements', 'Foot Diseases', 'Gizzard, Avian', 'Housing, Animal', 'Hydrogen-Ion Concentration', 'Phosphorus, Dietary', 'Poultry Diseases']
| 28,277,796
|
[['D08.811.277.352.650.700'], ['G07.203.300.300.100', 'J02.500.300.100'], ['J01.040.090'], ['B01.050'], ['D01.146.395'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['C17.800.174'], ['G07.203.650.240'], ['G07.203.300.456', 'J02.500.456'], ['C05.360', 'C17.800.321'], ['A13.853.355'], ['J03.340.250', 'N06.230.150.360.250'], ['G02.300'], ['D01.695.635'], ['C22.131.728']]
|
['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]']
| 1
| 1
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 0
|
[Serum monitoring of methotrexate (MTX) and 7-hydroxymethotrexate concentrations in patients treated with MTX using high-pressure liquid chromatography (HPLC) and comparison of serum MTX levels between HPLC method and fluorescence polarization immunoassay (FPIA)].
|
In order to measure simultaneously the serum levels of methotrexate (MTX) and its major metabolite, 7-hydroxymethotrexate (7-OH-MTX), in samples obtained from patients treated with MTX, we have investigated the reversed-phase high-pressure liquid chromatographic assay using ion-pairing reagents. The mobile phase consisted of 77.5% solution of 0.005M tetrabutylammonium and 22.5% acetonitrile. SEP-PAK C18 Cartridges were used for the precolumn. The detectable range of MTX and 7-OH-MTX were 0.02-0.03 and 1.0 mumol/l respectively. A significant positive correlation was observed (r = 0.983) between FPIA and HPLC methods. Serum MTX levels with FPIA were significantly (p less than 0.05) higher than those of HPLC method. The serum 7-OH-MTX levels at 24 hr and 48 hr were 4.857 +/- 1.383 (n = 10) and 1.835 +/- 0.286 (n = 6) mumol/l respectively with the dosage of 400 mg/m2. The serum 7-OH-MTX levels at 48 hr were 6.254 +/- 3.053 mumol/l (n = 5) with the dosage of 3,000 mg. The serum half lives of MTX and 7-OH-MTX were 8.05 +/- 1.03 (n = 4) and 14.8 +/- 1.35 (n = 6) hours respectively between 24 hr and 48 hr after administration. The T1/2 7-OH-MTX/MTX ratio was 1.8. Percent cross-reactivity of 7-OH-MTX with concentrations ranging from 1-10 mumol/l were 0.6-2.0% by FPIA. However, patients' serum levels of 7-OH-MTX were 15-85 times (n = 21) higher than those of MTX. MTX levels of containing both MTX and 7-OH-MTX (7-OH-MTX/MTX ratio was 50/1) were significantly higher than those of containing MTX alone by FPIA.
|
['Adult', 'Aged', 'Child, Preschool', 'Chromatography, High Pressure Liquid', 'Female', 'Fluorescence Polarization Immunoassay', 'Humans', 'Lymphoma, Non-Hodgkin', 'Male', 'Methotrexate', 'Middle Aged', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma']
| 2,053,771
|
[['M01.060.116'], ['M01.060.116.100'], ['M01.060.406.448'], ['E05.196.181.400.300'], ['E01.370.225.500.607.512.240.655.350', 'E01.370.225.750.551.512.240.655.350', 'E05.196.712.516.600.390.350', 'E05.200.500.607.512.240.655.350', 'E05.200.750.551.512.240.655.350', 'E05.478.566.159.350', 'E05.478.583.375.655.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386.480', 'C15.604.515.569.480', 'C20.683.515.761.480'], ['D03.633.100.733.631.192.500'], ['M01.060.116.630'], ['C04.557.337.428.600', 'C15.604.515.560.600', 'C20.683.515.528.600']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]']
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Effects of inhaled platelet activating factor on bronchial responsiveness in patients with symptomatic and asymptomatic pulmonary embolism.
|
To determine the possible role of platelet-activating factor (PAF) in pulmonary embolism (PE), the reactivity of the airways to inhaled PAF, using doses ranging from 6.25 to 400 micrograms, was examined in 24 patients with a past episode of PE. Twelve of these patients had experienced acute respiratory insufficiency during the episode (with or without additional symptoms). None of the remaining 12 patients had experienced any respiratory symptoms during the PE episode. Diagnosis was established by means of a ventilation-perfusion lung scan performed when admitted to the hospital because of deep venous thrombosis (DVT) in the lower limbs. Nonspecific bronchial reactivity as measured by the response to bronchoprovocation testing with methacholine showed no significant differences between both groups. PAF caused a dose-dependent bronchoconstriction defined by at least a 35 percent decrease in specific airway conductance (SGaw) in all patients. The average dose of PAF needed to decrease SGaw 35 percent was significantly lower in patients who had had a symptomatic PE than in those with asymptomatic PE (p = 0.011). This finding suggests that patients who suffered from symptomatic PE may present a greater airway reactivity to inhaled PAF. This different behavior might explain the existence of some of the respiratory symptoms of PE, which could be attributed to PAF-related effects. However, additional studies are needed to evaluate the role of PAF in PE.
|
['Administration, Inhalation', 'Bronchial Provocation Tests', 'Bronchoconstriction', 'Female', 'Humans', 'Lung', 'Male', 'Methacholine Chloride', 'Middle Aged', 'Platelet Activating Factor', 'Pulmonary Embolism', 'Radionuclide Imaging']
| 1,516,409
|
[['E02.319.267.050'], ['E01.370.386.700.125'], ['G09.772.705.700.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['D02.092.877.883.555.500', 'D02.675.276.534.500'], ['M01.060.116.630'], ['D02.033.100.291.211.500', 'D02.092.063.291.211.500', 'D02.092.877.883.333.710', 'D02.675.276.232.710', 'D10.570.755.375.760.400.985.910', 'D23.119.865', 'D23.469.050.600'], ['C08.381.746', 'C14.907.355.350.700'], ['E01.370.350.710', 'E01.370.384.730']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Ascertaining baseline levels of antiretroviral therapy adherence in Uganda: a multimethod approach.
|
BACKGROUND: Many antiretroviral treatment (ART) adherence measurement methods have been employed by different studies, but no single method has been found to be appropriate for all settings. This study aimed to determine baseline levels of adherence using 2 measures of adherence.METHODS: Levels of adherence in 967 patients continuing to receive ART in 4 health facilities were assessed over a 28-week period using a clinic-based pill count method and a patient self-report questionnaire. Factors associated with adherence were also determined.RESULTS: Mean adherence (95% confidence interval) was 97.3% (96.8% to 97.9%) and 98.4% (97.9% to 98.8%) for the clinic-based pill count and patient self-report methods, respectively. Proportion of clients achieving optimal adherence (? 95%) was 89.9% by pill count and 94.2% by self-report. The 2 adherence measures were closely correlated with each other (r = 0.87, P = 0.000). Adherence increased with age (P = 0.014) with patients aged 40 years and below being less likely to achieve optimal adherence [odds ratio = 0.55; 95% confidence interval (0.34 to 0.89)].CONCLUSIONS: There is a very high level of optimal adherence among patients still on treatment. The combined use of these 2 replicable and reliable methods of measuring adherence is vital to ART programs in resource-constrained settings.
|
['Adolescent', 'Adult', 'Age Factors', 'Anti-HIV Agents', 'Confidence Intervals', 'Female', 'HIV Infections', 'Humans', 'Linear Models', 'Male', 'Medication Adherence', 'Middle Aged', 'Multivariate Analysis', 'Odds Ratio', 'Prospective Studies', 'Surveys and Questionnaires', 'Uganda', 'Young Adult']
| 20,531,208
|
[['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['D27.505.954.122.388.077.088'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['F01.100.150.750.500.600.500', 'F01.145.488.887.500.600.500', 'N05.300.150.800.500.600.500'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['E05.318.740.600.600', 'G17.680.500', 'N05.715.360.750.625.590', 'N06.850.520.830.600.600'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['Z01.058.290.120.880'], ['M01.060.116.815']]
|
['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]']
| 0
| 1
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 1
|
Morphological and compositional changes of rat plasma triglyceride-rich lipoproteins incubated with adipose tissue.
|
Triglyceride-rich rat lipoproteins (mainly VLDL), purified by ultracentrifugation and dialysis, were incubated for 120 min in the presence of epididymal fat-pad pieces from fed rats in media containing heparin. During this process, the lipoproteins were depleted of triglycerides and proportionally enriched with proteins, causing their increased density. After incubation, electron microscopic study of the triglyceride-rich lipoproteins revealed partially degraded structures, and some particles had atypical discoid flattened form and marked lamellar structure. These findings are in agreement with those of Blanchette-Mackie & Scow (1976) in triglyceride hydrolysed chylomicrons and confirm their observation of monolayers formed by accumulated lipolytic products that move by lateral diffusion, giving rise to a spiral fold between the core triglycerides and the aqueous space.
|
['Adipose Tissue', 'Animals', 'Female', 'Kinetics', 'Lipoproteins', 'Lipoproteins, VLDL', 'Male', 'Microscopy, Electron', 'Rats', 'Triglycerides']
| 6,166,266
|
[['A10.165.114'], ['B01.050'], ['G01.374.661', 'G02.111.490'], ['D10.532', 'D12.776.521'], ['D10.532.599', 'D12.776.521.622'], ['E01.370.350.515.402', 'E05.595.402'], ['B01.050.150.900.649.313.992.635.505.700'], ['D10.351.801']]
|
['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Acid phosphatase in normal human blood cells: characterization by isoelectric focusing in polyacrylamide gel.
|
Using the high resolution technique of isoelectric focusing in polyacrylamide gel, isoenzymatic components could be discerned in acid phosphatase extracted from normal human lymphocytes, granulocytes, monocytes, and platelets. For each cell type, distinctive isoenzymatic patterns of acid phosphatase activity could be observed. These studies provide further evidence that various types of cellular differentiation are associated with differences in isoenzymatic components of acid phosphatase.
|
['Acid Phosphatase', 'Blood Cells', 'Blood Platelets', 'Electrophoresis, Polyacrylamide Gel', 'Granulocytes', 'Humans', 'Isoelectric Focusing', 'Lymphocytes', 'Monocytes']
| 477,774
|
[]
|
[]
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Rare cardiopulmonary complications of chronically decompensated myasthenia gravis.
|
Although myasthenia gravis (MG) is frequently mentioned in standard textbooks and journal articles as a rare cause for pulmonary hypertension and right heart failure, no case can actually be found in the literature. The case described in this report is the first documented case of chronically decompensated MG manifesting itself as pulmonary hypertension, severe right heart failure, and functional prolapse of both the mitral and tricuspid valves. Interestingly, no hepatic biochemical abnormalities were present in spite of significant congestive hepatomegaly.
|
['Female', 'Heart Failure', 'Humans', 'Hypertension, Pulmonary', 'Middle Aged', 'Mitral Valve Prolapse', 'Myasthenia Gravis', 'Tricuspid Valve Insufficiency']
| 7,420,443
|
[['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.423', 'C14.907.489.556'], ['M01.060.116.630'], ['C14.280.484.400.500'], ['C04.588.614.550.500', 'C04.730.856.490', 'C10.114.656', 'C10.574.781.588', 'C10.668.758.725', 'C20.111.258.500'], ['C14.280.484.856']]
|
['Diseases [C]', 'Organisms [B]', 'Named Groups [M]']
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Observations on the effects of barite on the gill tissues of the suspension feeder Cerastoderma edule (Linn?) and the deposit feeder Macoma balthica (Linn?).
|
Barite, an important component of offshore drilling muds, is shown to adversely affect the ctenidia of the suspension feeding bivalve, Cerastoderma edule and the deposit feeder, Macoma balthica. SEM observations showed that exposure to barite caused cilia to shorten and coagulate, and, in some extreme cases, cause the disintegration of the gill structure itself. Using a simple ciliary condition index (CCI) the impact of the barite was quantified and damage rates expressed. The bivalves were treated with daily doses of 1, 2, and 3-mm depth equivalents of barite. In all treatments significant damage to the gills was recorded although, in the case of the 1-mm dose rate, this did not occur for 4 days. In the other two treatments, damage was apparent within a day of exposure with 100% mortality occurring within 12 days. Macoma balthica appeared slightly more tolerant of exposure to barite than C. edule.
|
['Animals', 'Barium Sulfate', 'Cilia', 'Contrast Media', 'Dose-Response Relationship, Drug', 'Gills', 'Industry', 'Microscopy, Electron, Scanning', 'Mollusca', 'Petroleum', 'Water Pollutants']
| 11,382,987
|
[['B01.050'], ['D01.103.075', 'D01.875.800.800.850.075'], ['A11.284.180.165'], ['D27.505.259.500', 'D27.720.259'], ['G07.690.773.875', 'G07.690.936.500'], ['A13.421'], ['J01.576'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['B01.050.500.644'], ['D20.345.630', 'N06.230.132.258.630'], ['D27.888.284.903']]
|
['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 1
| 0
|
A Novel and Highly Potent Urotensin II Receptor Antagonist Inhibits Urotensin II-Induced Pressure Response in Mice.
|
This study was designed to characterize the pharmacological profile of DS37001789, which is a structurally novel piperazine derivative that acts as urotensin II (U-II) receptor antagonist. DS37001789 inhibited [I]-U-II binding to human GPR14, U-II receptor, with an IC50 value 0.9 nM. Its potency was superior to that of ACT-058362, a nonpeptide U-II receptor antagonist whose IC50 was 120 nM. Human U-II-induced vascular contraction was blocked by DS37001789. The dose-response curve of DS37001789 in rats and monkeys did not show species differences, and it shifted to the right without any effects on the maximum vascular response. Moreover, orally administered DS37001789 dose-dependently prevented human U-II-induced blood pressure elevation in mice, and this effect was significant at dose and higher dose (30 and 100 mg/kg), and its potency was superior to that of ACT-058362 (100 mg/kg). These results suggest that DS37001789 is a highly potent U-II receptor antagonist both in vitro and in vivo, with no marked species difference. DS37001789 would be a useful tool to clarify the physiological roles of U-II/GPR14 system. In addition, it can serve as a novel therapeutic agent for diseases in which the U-II/GPR14 system is upregulated, such as hypertension, heart failure, renal dysfunction, and diabetes.
|
['Animals', 'Antihypertensive Agents', 'Aorta, Thoracic', 'Arterial Pressure', 'CHO Cells', 'Cricetulus', 'Dose-Response Relationship, Drug', 'Female', 'Humans', 'Macaca fascicularis', 'Male', 'Mice, Inbred C57BL', 'Rats, Sprague-Dawley', 'Receptors, G-Protein-Coupled', 'Signal Transduction', 'Urotensins', 'Vasodilation']
| 30,608,334
|
[['B01.050'], ['D27.505.954.411.162'], ['A07.015.114.056.372'], ['G09.330.380.076.347'], ['A11.251.210.200', 'A11.436.155'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D12.776.543.750.695'], ['G02.111.820', 'G04.835'], ['D06.472.699.905', 'D12.644.548.905', 'D23.469.050.375.925'], ['G09.330.380.928']]
|
['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]']
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
[Traumatic rupture of the thoracic aorta].
|
A man aged 19 years sustained multiple injuries on account of deceleration. Radiography of the thorax revealed increase in width of the mediastinum. Aortography after 1 1/2 days revealed pseudocoarctation of the aorta corresponding to rupture of the aortic isthmus. This investigation should be undertaken on broad indications in patients with relevant injuries and increase in width of the mediastinum.
|
['Accidents, Traffic', 'Adult', 'Aorta, Thoracic', 'Aortic Rupture', 'Humans', 'Male', 'Radiography']
| 2,929,045
|
[['N06.850.135.392'], ['M01.060.116'], ['A07.015.114.056.372'], ['C14.907.055.185.125', 'C14.907.055.239.175', 'C14.907.109.139.175', 'C26.761.125'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700']]
|
['Health Care [N]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Robust surface-based multi-template automated algorithm to segment healthy and pathological hippocampi.
|
The most frequent drug-resistant epilepsy is temporal lobe epilepsy (TLE) related to hippocampal atrophy. In addition, TLE is associated with atypical hippocampal morphologies. Automatic hippocampal segmentations have generally provided unsatisfactory results in this condition. We propose a novel segmentation method (SurfMulti) to statistically estimate locoregional texture and shape using a surface-based approach that guarantees shape-inherent point-wise correspondences. To account for inter-subject variability, including shape variants, we used a multi-template library derived from a large database of controls and patients. SurfMulti outperformed state-of-the-art volume-based single- and multi-template approaches, with performances comparable to controls (Dice index: 86.1 vs. 87.5%). Furthermore, the sensitivity of SurfMulti to detect atrophy was similar to that of manual volumetry. Given that the presence of hippocampal atrophy in TLE predicts a favorable seizure outcome after surgery, the proposed automated algorithm assures to be a robust surrogate tool in the presurgical evaluation for the time-demanding manual procedure.
|
['Adult', 'Algorithms', 'Diagnosis, Computer-Assisted', 'Diagnostic Imaging', 'Epilepsy, Temporal Lobe', 'Female', 'Hippocampus', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Pattern Recognition, Automated', 'Reproducibility of Results']
| 22,003,730
|
[['M01.060.116'], ['G17.035', 'L01.224.050'], ['E01.158', 'L01.313.500.750.100.158'], ['E01.370.350'], ['C10.228.140.490.360.290', 'C10.228.140.490.493.375'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['L01.399.750'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']]
|
['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]']
| 1
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 1
| 1
| 1
| 0
|
Occupational asthma and contact dermatitis in a spray painter after introduction of an aziridine cross-linker.
|
A 23-year-old spray painter developed contact dermatitis and respiratory difficulty characterized by small airways obstruction shortly after the polyfunctional aziridine cross-linker CX-100 began to be used in his workplace as a paint activator. The symptoms resolved after he was removed from the workplace and was treated with inhaled and topical steroids. Painters may have an increased risk of asthma due to exposure to a variety of agents, such as isocyanates, alkyd resins, and chromates. This case illustrates the importance of using appropriate work practices and personal protective equipment to minimize exposure. Occupational asthma is diagnosed by a history of work-related symptoms and exposure to known causative agents. The diagnosis is confirmed by serial pulmonary function testing or inhalational challenge testing. The risk of asthma attributable to occupational exposures is probably underappreciated due to underreporting and to inappropriate use of narrow definitions of exposure in epidemiologic studies of attributable risk.
|
['Adult', 'Asthma', 'Aziridines', 'Dermatitis, Contact', 'Humans', 'Male', 'Occupational Diseases', 'Paint']
| 10,379,008
|
[['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['D03.383.097.217'], ['C17.800.174.255', 'C17.800.815.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C24'], ['J01.637.597']]
|
['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]']
| 0
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 1
| 0
| 0
|
Is Geriatric Depression Scale-15 a suitable instrument for measuring depression in Brazil? Results of a Rasch analysis.
|
Depressive symptoms are the most prevalent mental health condition in older adults. Since it cannot be measured directly, the use of instruments is mandatory. The 15-item Geriatric Depression Scale (GDS) is one of the most widely used scales to measure depression in the elderly. It is recognized that the cultural context is a major determinant of the instrument's psychometric performance. Up to the present, this scale has mainly been investigated through classical psychometric approaches. The present study aims to explore whether the 15-item GDS is a suitable instrument in a Brazilian sample. In addition, it explores the potential improvement in the psychometric performance by item refinement. Four hundred twenty-four elderly adults selected through convenience sampling completed the 15-item GDS. Data were analyzed by the Rasch Measurement Model. The Rasch analysis is a powerful modern approach to explore psychometric performance of instruments in health sciences. It examines both the scale and the individual item performance in depth. The 15-item GDS proved not to be suitable in a Brazilian sample. Item misfit and differential item functioning were responsible for considerable misperformance. Scale reduction led to a 10-item structure. This refined format presented adequate psychometric performance and no differential item functioning. The present study offers an alternative and more adequate version of the GDS to be applied in Brazilian subjects. It is also in line with the need for shorter, valid scales in clinical settings. Further investigations are needed to develop a set of cultural-invariant items, which could then be applied in transcultural investigations free of bias.
|
['Aged', 'Aged, 80 and over', 'Brazil', 'Depression', 'Female', 'Geriatric Assessment', 'Humans', 'Interviews as Topic', 'Male', 'Models, Psychological', 'Psychometrics', 'Surveys and Questionnaires']
| 20,835,969
|
[['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.107.757.176'], ['F01.145.126.350'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['E05.599.695'], ['F04.711.780'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']]
|
['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]']
| 0
| 1
| 0
| 0
| 1
| 1
| 0
| 0
| 1
| 0
| 1
| 1
| 1
| 1
|
Safety and immunogenicity of yellow fever 17D vaccine in adults receiving systemic corticosteroid therapy: an observational cohort study.
|
OBJECTIVE: To assess the safety and immunogenicity of live attenuated yellow fever (YF) 17D vaccine in adults receiving systemic corticosteroid therapy.METHODS: All adult travelers on systemic corticosteroid therapy who had received the YF17D vaccine in 24 French vaccination centers were prospectively enrolled and matched with healthy controls (1:2) on age and history of YF17D immunization. Safety was assessed in a self-administered standardized questionnaire within 10 days after immunization. YF-specific neutralizing antibody titers were measured 6 months after vaccination in patients receiving corticosteroids.RESULTS: Between July 2008 and February 2011, 102 vaccine recipients completed the safety study (34 receiving corticosteroids and 68 controls). The median age was 54.9 years (interquartile range [IQR] 45.1-60.3 years) and 45 participants had a history of previous YF17D immunization. The median time receiving corticosteroid therapy was 10 months (IQR 1-67 months) and the prednisone or equivalent dosage was 7 mg/day (IQR 5-20). Main indications were autoimmune diseases (n = 14), rheumatoid arthritis (n = 9), and upper respiratory tract infections (n = 8). No serious adverse event was reported; however, patients receiving corticosteroids reported more frequent moderate/severe local reactions than controls (12% and 2%, respectively; relative risk 8.0, 95% confidence interval 1.4-45.9). All subjects receiving corticosteroids who were tested (n = 20) had neutralizing antibody titers >10 after vaccination.CONCLUSION: After YF17D immunization, moderate/severe local reactions may be more frequent in patients receiving systemic corticosteroid therapy. Immunogenicity seems satisfactory. Large-scale studies are needed to confirm these results.
|
['Adrenal Cortex Hormones', 'Adult', 'Arthralgia', 'Cohort Studies', 'Fatigue', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Surveys and Questionnaires', 'Yellow Fever', 'Yellow Fever Vaccine', 'Yellow fever virus']
| 23,554,297
|
[['D06.472.040'], ['M01.060.116'], ['C05.550.091', 'C23.888.592.612.094', 'F02.830.816.444.350', 'G11.561.790.444.350'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C23.888.369'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['C01.920.500.980', 'C01.925.081.980', 'C01.925.782.350.250.980', 'C01.925.782.417.881'], ['D20.215.894.899.970'], ['B04.820.578.344.350.990']]
|
['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]']
| 0
| 1
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
4-D x 3-D ultrasound: real-time scan conversion, filtering, and display of displacement vectors with a motorized curvilinear transducer.
|
Recent research in the field of elastography has sought to expand displacement tracking to three dimensions. Once the 3-D volumes of displacement data have been obtained, they must be scan converted so that further processing, such as inversion methods to obtain tissue elasticity, can take place in Cartesian coordinates. This paper details an efficient and geometrically accurate algorithm to scan convert 3-D volumes of displacement vectors obtained from a motorized sector transducer. The proposed algorithm utilizes the physical scan geometry to convert the 3-D volumes of displacement data to both Cartesian coordinates and Cartesian displacements. Spatially varying filters are also proposed to prevent aliasing while minimizing data loss. Validation of the system has shown the algorithm to be correct to floating point precision, and the 3-D scan conversion and filtering can be performed faster than the native rate of data acquisition for the motorized transducer.
|
['Algorithms', 'Animals', 'Female', 'Humans', 'Imaging, Three-Dimensional', 'Kidney', 'Phantoms, Imaging', 'Reproducibility of Results', 'Swine', 'Transducers', 'Ultrasonography', 'Ultrasonography, Mammary']
| 20,889,415
|
[['G17.035', 'L01.224.050'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['A05.810.453'], ['E07.671'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['B01.050.150.900.649.313.500.880'], ['E07.305.812'], ['E01.370.350.850'], ['E01.370.350.850.860', 'E01.370.378.850']]
|
['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]']
| 1
| 1
| 0
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 1
| 0
| 1
| 0
|
Theory-practice integration in selected clinical situations.
|
The current changes in health care systems challenge knowledgeable, mature and independent practitioners to integrate theoretical content with practice. The aim of this study was to investigate the problems of integrating theory with practice in selected clinical nursing situations. The study focused on rendering of family planning services to clients as a component of Community Nursing Science. Structured observation schedules were used to observe the theoretical content of the curriculum as well as the practical application of what has been taught in the clinical area. The findings of the study revealed that there was a need for an integrated holistic curriculum, which would address the needs of the community. It was concluded that a problem-based and community-based curriculum, intersectoral collaboration between college and hospital managements and student involvement in all processes of teaching and learning would improve the integration of theory and practice. There also appeared to be a need for tutors to be more involved in clinical teaching and accompaniment.
|
['Community Health Nursing', 'Curriculum', 'Family Planning Services', 'Humans', 'Nursing Education Research', 'Nursing Theory']
| 11,993,262
|
[['H02.478.676.150', 'N02.421.143.150'], ['I02.158'], ['N02.421.143.401', 'N02.421.800.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.770.644.145.390.413', 'H02.478.395.413', 'I02.358.462.612', 'N04.590.233.508.613.413'], ['H02.478.408']]
|
['Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]']
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
| 0
| 0
| 1
| 0
|
Differential localization of calmodulin, the 67kDa calcimedin and calpactin II in secretory ameloblasts.
|
By using specific antibodies, we have shown by Western blots that dental tissues contain calmodulin, the 67 kDa calcimedin and calpactin II. Moreover, by immunogold electron microscopy, we were able to compare the intracellular distribution of these three calcium-binding proteins in secretory ameloblasts. They were all found in the cytosol of these cells but only calcimedin was detected in the mitochondria. Calpactin II was the only one present in secretory vesicles. Twice as much calmodulin and calpactin II were detected in cell bodies as in Tomes' processes, but calcimedin was more abundant in the latter. The presence of these calcium mediators in well defined areas of ameloblasts may indicate differential ways for these cells to regulate different calcium-dependent processes during enamel formation.
|
['Ameloblasts', 'Animals', 'Annexins', 'Calcium-Binding Proteins', 'Calmodulin', 'Immunohistochemistry', 'Molecular Weight', 'Rats', 'Subcellular Fractions']
| 2,532,118
|
[['A11.436.107'], ['B01.050'], ['D12.776.157.125.050'], ['D12.776.157.125'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['G02.494'], ['B01.050.150.900.649.313.992.635.505.700'], ['A11.284.835']]
|
['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
|
Silencing profilin-1 inhibits endothelial cell proliferation, migration and cord morphogenesis.
|
Expression of several actin-binding proteins including profilin-1 is up-regulated during capillary morphogenesis of endothelial cells, the biological significance of which remains unknown. Specifically, we hypothesized that profilin-1 is important for endothelial migration and proliferation. In this study, we suppressed profilin-1 expression in human umbilical vein endothelial cells by RNA-interference. Gene silencing of profilin-1 led to significant reduction in the formation of actin filaments and focal adhesions. Loss of profilin-1 expression was also associated with reduced dynamics of cell-cell adhesion. Data from both wound-healing experiments and time-lapse imaging of individual cells showed inhibition of cell migration when profilin-1 expression was suppressed. Cells lacking profilin-1 exhibited defects in membrane protrusion, both in terms of its magnitude and directional persistence. Furthermore, loss of profilin-1 expression inhibited cell growth without compromising cell survival, at least in the short-term, thus suggesting that profilin-1 also plays an important role in endothelial proliferation as hypothesized. Finally, silencing profilin-1 expression suppressed matrigel-induced early cord morphogenesis of endothelial cells. Taken together, our data suggest that profilin-1 may play important role in biological events that involve endothelial proliferation, migration and morphogenesis.
|
['Actins', 'Cell Adhesion', 'Cell Movement', 'Cell Proliferation', 'Cells, Cultured', 'Cytoskeleton', 'Embryo, Mammalian', 'Endothelial Cells', 'Extracellular Matrix', 'Humans', 'Morphogenesis', 'Profilins', 'RNA Interference', 'Umbilical Cord']
| 16,968,742
|
[['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['G04.022'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['A11.284.430.214.190.750'], ['A16.254'], ['A11.436.275'], ['A11.284.295.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.345.500'], ['D05.750.078.730.637', 'D12.776.210.500.775', 'D12.776.220.525.637'], ['G05.308.203.374.790'], ['A16.378.693']]
|
['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]']
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Near-UV circular dichroism of trypsin inhibitor of adzuki beans attributable to disulfide groups.
|
The trypsin inhibitor of adzuki (Phaseolus angularis) beans shows a CD spectrum with a negative extremum at 280 nm and a positive shoulder around 245 nm. Since the inhibitor lacks tryptophan and tyrosine, the observed CD spectrum can be attributed to the six disulfide groups in the molecule. The CD features completely disappeared on reduction of the disulfide groups, and converged into a single negative extremum at 270 nm when the groups were modified to form mixed disulfides with glutathione. These observations of the CD properties of the inhibitor strongly suggest the presence of disulfide groups constrained with respect to their dihedral angles.
|
['Circular Dichroism', 'Disulfides', 'Glutathione', 'Hydrogen-Ion Concentration', 'Plants', 'Trypsin Inhibitors']
| 10,285
|
[['E05.196.867.151'], ['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['D12.644.456.448'], ['G02.300'], ['B01.650'], ['D27.505.519.389.745.800.900']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]']
| 0
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Lichenoid drug eruption induced by colchicine: case report.
|
Lichenoid drug eruption (LDE) is a common cutaneous side effect of drugs including antimalarials, antihypertensives, nonsteroids, anti-inflammatory drugs and diuretics. The physiopathologic relationship between colchicine treatment and LDE is unclear. There is very little documentation of LDE induced by colchicine in the literature. In this report, we present a case that developed LDE on the abdomen and the legs during the colchicine treatment.
|
['Abdomen', 'Administration, Cutaneous', 'Administration, Oral', 'Colchicine', 'Drug Eruptions', 'Exanthema', 'Female', 'Histamine Antagonists', 'Humans', 'Hyperpigmentation', 'Leg', 'Lichenoid Eruptions', 'Middle Aged', 'Mometasone Furoate', 'Pruritus', 'Skin', 'Stomatitis, Aphthous']
| 27,345,420
|
[['A01.923.047'], ['E02.319.267.120.060'], ['E02.319.267.100'], ['D03.132.225'], ['C17.800.174.600', 'C20.543.206.380', 'C25.100.468.380'], ['C17.800.257'], ['D27.505.519.625.375.425', 'D27.505.696.577.375.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.621.430'], ['A01.378.610.500'], ['C17.800.859.475'], ['M01.060.116.630'], ['D04.210.500.745.432.719.526'], ['C17.800.685', 'C23.888.885.625'], ['A17.815'], ['C07.465.864.750']]
|
['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]']
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Chromatography for rapid buffer exchange and refolding of secretory leukocyte protease inhibitor.
|
A DEAE-cellulose stationary phase in a rolled configuration was used to separate recombinant secretory leukocyte protease inhibitor (rSLPI) from denaturants and reducing agents (3 M guanidine-HCl and 5 mM DTT) in less than 5 min to promote refolding of the protein to an active form. The mobile phase consisted of buffer and 500 mM NaCl, where NaCl suppressed binding of protein to this stationary phase. Separation of an initial concentration of 2 mg/mL protein from the other constituents resulted in 96% recovery of the rSLPI at an average concentration of 1.28 mg/mL. When incubated for 4 h at 20 degrees C, the fractionated rSLPI gave a 46% yield of properly refolded protein. The protein concentration was 6.4 times higher than that reported in a previously published method, where refolding was carried out by diluting the mixture of protein, denaturants, and reducing agents by a factor of 10. The results show that a combination of rapid chromatographic separation over a cellulosic stationary phase followed by protein refolding will significantly enhance process throughput by minimizing tankage, water requirements, and process time.
|
['Chromatography, DEAE-Cellulose', 'Protein Folding', 'Proteinase Inhibitory Proteins, Secretory', 'Proteins', 'Recombinant Proteins', 'Serine Proteinase Inhibitors']
| 8,857,186
|
[['E05.196.181.400.383.349'], ['G01.154.651', 'G02.111.688'], ['D12.644.822', 'D12.776.645'], ['D12.776'], ['D12.776.828'], ['D27.505.519.389.745.800']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]']
| 0
| 0
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Supporting lower-income working women to initiate breastfeeding: Learning who is breastfeeding and what helps.
|
BACKGROUND AND PURPOSE: Based on the Women, Work, and Wee Ones longitudinal study, mothers' likelihood of breastfeeding is examined across demographic and health variables.METHODS: Frequencies of breastfeeding and cosleeping by 285 mothers from the Women, Work, and Wee Ones cohort are reported as related to mothers' work schedule, marital status, or mother or infant health.CONCLUSIONS: Breastfeeding rates were about 30% across most maternal characteristics. The frequency of mothers' breastfeeding was higher when mothers were both breastfeeding and cosleeping (breastfeeding-cosleeping), in comparison with breastfeeding only, as evident for mothers with nonstandard work schedules. Cosleeping was common across all mothers. Breastfeeding rates were low, perhaps reflecting challenges of early care. Premature infants were more likely to be cosleeping than breastfeeding. Approximately 30% of mothers breastfed across the different factors examined.IMPLICATIONS FOR PRACTICE: The information may help nurse practitioners in addressing early care needs and supporting breastfeeding across groups. Younger mothers were least likely to breastfeed and reported higher frequency of cosleeping. Overall breastfeeding frequency was higher when mothers were cosleeping. Nurse practitioners may find it important to provide clear information about safe infant sleep and safe approaches to protecting infants.
|
['Breast Feeding', 'Continental Population Groups', 'Educational Status', 'Female', 'Humans', 'Longitudinal Studies', 'Mothers', 'North Carolina', 'Poverty', 'Women, Working']
| 30,211,822
|
[['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['M01.686.508'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['Z01.107.567.875.075.475', 'Z01.107.567.875.750.530'], ['I01.880.735.634', 'I01.880.853.996.535', 'N01.824.600'], ['M01.975.825']]
|
['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]']
| 0
| 1
| 0
| 0
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 1
| 1
|
A placebo-controlled randomized double-blind study of adjuvant intrapleural BCG in patients with resected T1N0, T1N1, or T2N0 squamous cell carcinoma, adenocarcinoma, or large cell carcinoma of the lung. LCSG Protocol 771.
|
This article reviews the design and findings of LCSG Protocol 771, a randomized double-blind comparison of postoperative adjuvant intrapleural bacillus Calmette-Gu?rin (BCG) against saline solution placebo control in 473 patients with resected T1N0, T1N1, or T2N0 non-small cell lung cancer. Patients were randomized from August 30, 1977, through October 20, 1980, and follow-up ended on January 1, 1990. There was no evidence of improved survival or time to recurrence among patients given BCG in contrast to earlier promising findings. A calculation suggests that false-positive results due to chance are not uncommon in small preliminary studies, indicating the need for larger confirmatory trials such as LCSG Protocol 771. Other contributions from this Protocol are also reviewed, including data on BCG toxicity, immunologic effects, patterns of recurrence, and identification of prognostic risk groups.
|
['Adenocarcinoma', 'BCG Vaccine', 'Carcinoma, Non-Small-Cell Lung', 'Carcinoma, Squamous Cell', 'Combined Modality Therapy', 'Double-Blind Method', 'Follow-Up Studies', 'Humans', 'Lung Neoplasms', 'Neoplasm Recurrence, Local', 'Prognosis', 'Risk Factors', 'Survival Rate', 'Treatment Outcome']
| 7,988,246
|
[['C04.557.470.200.025'], ['D20.215.894.135.825.100'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.186'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04.697.655', 'C23.550.727.655'], ['E01.789'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725'], ['E05.318.308.985.550.900', 'N01.224.935.698.826', 'N06.850.505.400.975.550.900', 'N06.850.520.308.985.550.900'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]']
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
|
Brief report: Physician discomfort and variability with disability assessments.
|
BACKGROUND: Completing a disability assessment is a common physician task; yet, little formal training is available.OBJECTIVE: To assess physician comfort with disability assessments, and evaluate their consistency.DESIGN: We conducted 2 separate surveys. The "Comfort" survey asked physicians to rate their comfort (1 = very uncomfortable to 10 = very comfortable) with 12 potentially uncomfortable tasks, including disability assessment. The second survey described 2 different patients requesting disability assessment, 1 with acute and the other with chronic back pain; participants assigned each a level of disability.PARTICIPANTS: Resident and staff physicians at an urban county hospital.RESULTS: For 54 physicians returning "Comfort" surveys, disability assessment had the lowest average comfort rating (4.3, SD 1.9) compared with all other tasks (mean ratings ranged from 4.8 to 8.0). For the 73 physicians returning the "Disability Cases" survey, 88% found Case 1 qualified for limited employment, but varied on the types of limitations imposed. For Case 2, 39% assigned no disability, 39% limited employment, and 22% full disability.CONCLUSIONS: Our pilot studies support the hypothesis that physicians are not comfortable with disability assessment, and their assessments can be highly variable. Physician discomfort and lack of training may contribute to variability in disability assessments.
|
['Adult', 'Attitude of Health Personnel', 'Back Injuries', 'Disability Evaluation', 'Disabled Persons', 'Female', 'Health Care Surveys', 'Humans', 'Internal Medicine', 'Internship and Residency', 'Low Back Pain', 'Middle Aged', 'Physicians', 'Pilot Projects']
| 16,117,755
|
[['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['C26.117'], ['E01.370.400'], ['M01.150'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.429'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['C23.888.592.612.107.400'], ['M01.060.116.630'], ['M01.526.485.810', 'N02.360.810'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720']]
|
['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]']
| 0
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 1
| 1
| 0
|
Effects of hormone-releasing stimuli on the area of the perivascular space in the neural lobe of the rat.
|
Neural lobes from rats subjected to neurohypophysial hormone-releasing stimuli were examined electron microscopically following fixation in 4% tannic acid in 2.5% glutaraldehyde. This fixation allowed the delineation of the perivascular space in the neural lobe tissue. Measurement of the area of the perivascular space showed that it was significantly increased in the rats subjected to vagal stimulation and intraarterial calcium ions compared to the control rats. The rats which had been subjected to haemorrhage as a hormone-releasing stimulus did not show any significant change in the area of the perivascular space. The significance of these findings in relation to hormone release is discussed.
|
['Animals', 'Calcium', 'Extracellular Space', 'Hemorrhage', 'Male', 'Pituitary Gland, Posterior', 'Rats', 'Vagus Nerve']
| 688,367
|
[['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A10.082.500', 'A11.284.295'], ['C23.550.414'], ['A06.300.747.875', 'A06.688.178.875', 'A06.688.357.750.875', 'A08.186.211.180.497.352.435.500.875', 'A08.186.211.200.317.357.352.435.500.875', 'A08.713.049.875', 'A08.713.357.750.875'], ['B01.050.150.900.649.313.992.635.505.700'], ['A08.800.050.050.925', 'A08.800.050.600.825', 'A08.800.800.060.920', 'A08.800.800.120.900']]
|
['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]']
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Increased tissue endothelin-1-like immunoreactivity in the internal mammary artery of patients with diabetes or hypercholesterolemia modulates the graft flow in the peri-operative period.
|
OBJECTIVE: Peri-operative ischemic episodes following coronary artery bypass grafting with the internal mammary artery (IMA) are thought to be due to a vasospasm of this conduit. Endothelin-1 (ET-1) is a potent vasoconstrictor by itself and increases the response to other vasoconstrictor stimuli. This study focused on the possible role of an enhanced tissue ET-1-like immunoreactivity in the perioperative reaction of the IMA in patients with diabetes or hypercholesterolemia.METHODS: Specimens of the distal part of the IMA from 46 patients (mean age 58.5 years, four women, 42 men) were studied prospectively. Nine of those patients were diabetic and 26 had evidence of hypercholesterolemia. Another cohort of 20 IMA specimens was stained retrospectively; 10 of those biopsies were from patients that had experienced transient ischemic events peri-operatively in the myocardial area supplied by the IMA. The biopsies were examined histologically and immunohistochemically (rabbit polyclonal ET-1 antiserum, three-step avidin-biotin complex) with regard to their immunoreactivity to tissue ET-1.RESULTS: An immunoreactivity to ET-1 (graded 0-3) was present in 89% of the biopsies. The reactivity was significantly higher in patients with hypercholesterolemia ( 1.92+/-0.74) when compared to controls (1.0+/-0.63) (P = 0.04). The reactivity was also increased in patients with non-insulin-dependent diabetes mellitus (2.1+/-0.79), when compared to controls (P = 0.02). Mostly transient ischemic events in the area supplied by the IMA seemed to occur more frequently when the biopsies revealed a higher immunoreactivity to ET-1. They showed an increased reactivity to ET-1 (2.27+/-0.76) compared to 10 patients with an uneventful peri-operative course (1.66+/-0.71 ) (P = 0.04).CONCLUSIONS: This study provides evidence that the internal mammary artery is not a passive conduit. Vasospasm or vasoconstriction, in particular at its distal end, may occur more frequently in patients with hypercholesterolemia or diabetes, and may lead to post-operative ischemic events.
|
['Biopsy', 'Cohort Studies', 'Coronary Circulation', 'Diabetes Mellitus, Type 2', 'Endothelin-1', 'Endothelium, Vascular', 'Female', 'Humans', 'Hypercholesterolemia', 'Immunohistochemistry', 'Internal Mammary-Coronary Artery Anastomosis', 'Intraoperative Complications', 'Male', 'Mammary Arteries', 'Middle Aged', 'Myocardial Ischemia', 'Prospective Studies', 'Retrospective Studies', 'Vasoconstriction', 'Vasoconstrictor Agents']
| 9,845,140
|
[['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G09.330.100.324'], ['C18.452.394.750.149', 'C19.246.300'], ['D12.644.276.400.225', 'D12.776.467.400.225', 'D23.529.400.225'], ['A07.015.700.500', 'A10.272.491.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.584.500.500.396'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['E04.100.376.719.332.400', 'E04.100.814.868.750.400', 'E04.928.220.520.220.380'], ['C23.550.505'], ['A07.015.114.891.525'], ['M01.060.116.630'], ['C14.280.647', 'C14.907.585'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['G09.330.380.925'], ['D27.505.954.411.793']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Named Groups [M]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 1
| 1
| 0
|
Percutaneous aortic valve implantation using novel imaging guidance.
|
Thorough imaging of the aortic valve and related structures is highly important before and during percutaneous valve implantation. However, imaging modalities currently used in the catheterization room, namely, conventional aortography and transesophageal echocardiography are limited in guiding the precise valve placement during the implantation procedure. A novel real-time imaging modality capable of three-dimensional reconstruction of the ascending aorta has recently been introduced (CardioOp-THV, C-THV, Paieon Inc., Park Afek, Israel). We applied this system during a complex procedure of percutaneous aortic valve implantation in a patient with severe aortic tortuosity, large aortic-valve angulation, and asymmetric septal hypertrophy. We found the guidance system very helpful not only for accurate positioning of the valve but also for selecting the optimal projection for valve implantation, selecting the prosthetic valve size, and evaluating the results after deployment.
|
['Aorta', 'Aortic Valve', 'Aortic Valve Stenosis', 'Aortography', 'Cardiac Catheterization', 'Echocardiography, Transesophageal', 'Femoral Artery', 'Heart Valve Prosthesis', 'Heart Valve Prosthesis Implantation', 'Humans', 'Imaging, Three-Dimensional', 'Male', 'Prosthesis Design', 'Radiographic Image Interpretation, Computer-Assisted', 'Radiography, Interventional', 'Tomography, X-Ray Computed', 'Treatment Outcome']
| 20,552,651
|
[['A07.015.114.056'], ['A07.541.510.110'], ['C14.280.484.048.750', 'C14.280.955.249'], ['E01.370.350.700.060.070', 'E01.370.370.050.070'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E01.370.350.130.750.235', 'E01.370.350.850.220.235', 'E01.370.370.380.220.235'], ['A07.015.114.351'], ['E07.695.310'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['E05.320.550', 'E07.695.680'], ['E01.158.600.680', 'E01.370.350.350.700', 'E01.370.350.700.705', 'L01.313.500.750.100.158.600.680'], ['E01.370.350.700.725', 'E04.502.780'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 1
| 0
|
Risk profiles and pattern of antithrombotic use in patients with non-valvular atrial fibrillation in Thailand: a multicenter study.
|
BACKGROUND: Anticoagulation therapy is a standard treatment for stroke prevention in patients with non-valvular atrial fibrillation (NVAF) that have risk factors for stroke. However, anticoagulant increases the risk of bleeding, especially in Asians. We aimed to investigate the risk profiles and pattern of antithrombotic use in patients with NVAF in Thailand, and to study the reasons for not using warfarin in this patient population.METHODS: A nationwide multicenter registry of patients with NVAF was created that included data from 24 hospitals located across Thailand. Demographic data, atrial fibrillation-related data, comorbid conditions, use of antithrombotic drugs, and reasons for not using warfarin were collected. Data were recorded in a case record form and then transferred into a web-based system.RESULTS: A total of 3218 patients were included. Average age was 67.3 ± 11.3 years, and 58.2% were male. Average CHADS2, CHA2DS2-VASc, and HAS-BLED score was 1.8 ± 1.3, 3.0 ± 1.7, and 1.5 ± 1.0, respectively. Antiplatelet was used in 26.5% of patients, whereas anticoagulant was used in 75.3%. The main reasons for not using warfarin in those with CHA2DS2-VASc ?2 included already taking antiplatelet (26.6%), patient preference (23.1%), and using non-vitamin K antagonist oral anticoagulants (NOACs) (22.7%). Anticoagulant was used in 32.3% of CHA2DS2-VASc 0, 56.8% of CHA2DS2-VASc 1, and 81.6% of CHA2DS2-VASc ?2. The use of NOACs increased from 1.9% in 2014 to 25.6% in 2017.CONCLUSIONS: Anticoagulation therapy was prescribed in 75.3% of patients with NVAF. Among those receiving anticoagulant, 90.9% used warfarin and 9.1% used NOACs. The use of NOACs increased over time.
|
['Aged', 'Anticoagulants', 'Atrial Fibrillation', 'Clinical Decision-Making', 'Drug Prescriptions', 'Female', 'Fibrinolytic Agents', 'Hemorrhage', 'Humans', 'Male', 'Middle Aged', 'Patient Preference', 'Platelet Aggregation Inhibitors', "Practice Patterns, Physicians'", 'Registries', 'Risk Factors', 'Stroke', 'Thailand', 'Time Factors', 'Treatment Outcome', 'Warfarin']
| 30,144,802
|
[['M01.060.116.100'], ['D27.505.954.502.119'], ['C14.280.067.198', 'C23.550.073.198'], ['E01.055'], ['E02.319.307', 'N02.421.668.778.500'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.100.150.750.625.500', 'F01.145.488.887.625.500', 'N04.452.822.700.500', 'N05.300.150.800.625.500'], ['D27.505.954.502.780'], ['N04.590.374.577', 'N05.300.625'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.360.300.715.700', 'N06.850.520.308.970'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725'], ['C10.228.140.300.775', 'C14.907.253.855'], ['Z01.252.145.841'], ['G01.910.857'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['D03.383.663.283.446.520.914', 'D03.633.100.150.446.520.914']]
|
['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Phenomena and Processes [G]']
| 0
| 1
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 1
|
Renal and retroperitoneal metastasis from prostate adenocarcinoma: a case report.
|
BACKGROUND: Diffuse renal and retroperitoneal metastasis of prostatic origin is an uncommon spread pattern of prostate cancer.CASE PRESENTATION: We described a 74-year-old male patient who was admitted because of dysuria and nocturia. Physical examination and imaging study indicated prostate mass, and laboratory analysis revealed elevated prostate specific antigen (PSA). The diagnosis of prostate cancer was established after biopsy. In the further evaluation, diffuse renal and retroperitoneal metastasis of prostate cancer was confirmed. Radiotherapy combined with endocrine therapy was given.CONCLUSIONS: Our present case emphasized that the routine metastatic work-up was quite necessary, since a small proportion of men with advanced prostate cancer might experience metastases in atypical sites.
|
['Adenocarcinoma', 'Aged', 'Chemoradiotherapy', 'Humans', 'Kidney Neoplasms', 'Male', 'Neoplasm Grading', 'Prognosis', 'Prostatic Neoplasms', 'Retroperitoneal Neoplasms']
| 26,957,001
|
[['C04.557.470.200.025'], ['M01.060.116.100'], ['E02.186.079', 'E02.319.164', 'E02.815.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['E01.789.612'], ['E01.789'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['C04.588.033.731']]
|
['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]']
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
A study, by electron microscopy, of the specific uptake of alpha-fetoprotein by mouse embryonic fibroblasts in relation to in vitro aging, and by human mammary epithelial tumour cells in comparison with normal donors' cells.
|
A covalent conjugate of alpha-foetoprotein (AFP) and horseradish peroxidase (HRP) has been used to follow the internalization pathway of this serum protein in early and late passages of primary cultures of mouse embryonic fibroblasts as well as in a spontaneously immortalized cell line. AFP, as transferrin (Tf) used in parallel as a control, are endocytosed through coated pits and vesicles and move then to endosomes in every case; in cells of the late passages, at least a part of the internalized proteins would be routed to lysosomes. Cells of three different established human mammary cancer lines (MCF-7, Evsa-T, T-47D) internalize AFP-HRP through coated pits and vesicles. Such localization of the conjugate is practically never detected in normal human mammary epithelial cells in primary culture. Taken together, these results are in agreement with the view that AFP receptors are expressed at the surface of proliferating mouse embryonic fibroblasts and human mammary epithelial cancer cells but absent from the surface of normal human mature cells of the same origin.
|
['Animals', 'Biological Transport', 'Breast Neoplasms', 'Cell Line', 'Cell Survival', 'Endocytosis', 'Epithelium', 'Female', 'Fibroblasts', 'Humans', 'Mammary Neoplasms, Animal', 'Mice', 'Mice, Inbred Strains', 'Tumor Cells, Cultured', 'alpha-Fetoproteins']
| 1,709,818
|
[['B01.050'], ['G03.143'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210'], ['G04.346'], ['G04.417'], ['A10.272'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.531', 'C22.520'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['A11.251.860'], ['D12.776.124.790.106.092', 'D12.776.320.525.500', 'D12.776.377.228.500', 'D12.776.377.715.085.092', 'D23.101.140.050']]
|
['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]']
| 1
| 1
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Optimal resistance training: comparison of DeLorme with Oxford techniques.
|
OBJECTIVE: Progressive resistive exercises, such as the DeLorme or Oxford techniques, improve strength by adding weights to arrive at the ten-repetition maximum (10RM; DeLorme) or by starting at the 10RM and removing weight (Oxford). The goal of this study was to examine the efficacy of each training method.DESIGN: In this randomized, prospective, group design, evaluator-blind clinical trial, 50 subjects performed either the Oxford or DeLorme weight-training techniques. Three times a week for 9 wks, subjects completed three sets of ten-repetition knee extensions based on the 10RM measured weekly. Incremental or decremental changes in training weight were utilized in training sessions based on the protocol randomly assigned to each subject.RESULTS: The mean 10RM increase was 71.9 kg for the DeLorme group and 67.5 kg for the Oxford group, which was not significantly different. Examination with repeated measures multivariate analysis of variance revealed no significant difference between the two groups for 10RM increase, and no significant sex differences were found. Percentage change scores were not significantly different for 1RM and 10RM for both protocols and sexes.CONCLUSION: Both protocol groups were able to complete their lifting assignments and progressed similarly in weekly 10RM weight lifted. It can be concluded that both the DeLorme and Oxford protocols improve strength with equivalent efficacy. Further studies involving a larger sample size are needed to address potential sex-specific changes in strength improvement in response to the protocols.
|
['Adult', 'Exercise', 'Female', 'Humans', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Muscle, Skeletal', 'Physical Fitness', 'Prospective Studies']
| 14,627,926
|
[['M01.060.116'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['A02.633.567', 'A10.690.552.500'], ['G11.427.685', 'I03.450.642.845.054.800', 'N01.400.545'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650']]
|
['Named Groups [M]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]']
| 1
| 1
| 0
| 0
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 1
| 1
| 0
|
Use of temozolomide with other cytotoxic chemotherapy in the treatment of patients with recurrent brain metastases from lung cancer.
|
The use of chemotherapy for the treatment of brain metastases arising from lung cancer has been limited by poor efficacy and high toxicity. Temozolomide, an orally bioavailable alkylating agent that crosses the blood-brain barrier, has activity against brain metastases from both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) when used as a single agent, but response rates are low. Preclinical experiments and early clinical studies in other malignancies indicate that temozolomide may have additive or synergistic effects when used with other chemotherapeutic agents. We report a case of a patient with SCLC with recurrent brain metastases after treatment with multiple chemotherapeutic regimens and whole-brain radiation therapy (WBRT) who was treated with temozolomide (150 mg/m(2) for 5 days in a 28-day cycle) and oral etoposide (50 mg/m(2) for 10 days in a 28-day cycle). A second patient with NSCLC and brain metastases who progressed after treatment with chemotherapy and WBRT was treated with temozolomide (150 mg/m(2) for 5 days in a 28-day cycle) and gemcitabine (1,000 mg/m(2) weekly for 2 weeks in a 3- week cycle). In both patients, the temozolomide regimens were extremely well tolerated and resulted in dramatic and durable responses. The combination of temozolomide with other chemotherapeutic agents represents a promising strategy for treating patients with lung cancer and recurrent brain metastases and merits further study.
|
['Antineoplastic Agents, Alkylating', 'Antineoplastic Combined Chemotherapy Protocols', 'Brain Neoplasms', 'Carcinoma, Non-Small-Cell Lung', 'Carcinoma, Small Cell', 'Combined Modality Therapy', 'Dacarbazine', 'Etoposide', 'Female', 'Humans', 'Lung Neoplasms', 'Middle Aged', 'Prognosis', 'Temozolomide', 'Treatment Outcome']
| 12,604,733
|
[['D27.505.519.124.035', 'D27.505.954.248.150', 'D27.888.569.035.035'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['C04.557.470.200.380'], ['E02.186'], ['D02.925.200', 'D03.383.129.308.240'], ['D02.455.426.559.847.638.960.675.250', 'D04.615.638.960.675.250', 'D09.408.348.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['E01.789'], ['D02.925.200.500', 'D03.383.129.308.240.500'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]']
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
[Diagnostic value of bronchoscopy in diagnosis of pulmonary tuberculosis: bronchial aspirate, bronchial washing and transbronchial lung biopsy].
|
The diagnosis of pulmonary tuberculosis is confirmed by the detection of Mycobacterium tuberculosis in sputum. Bronchoscopy has been used for diagnosis of various pulmonary diseases. The value of bronchoscopy such as bronchial aspirate, bronchial washing and transbronchial lung biopsy in diagnosis of pulmonary tuberculosis was evaluated, and the results were as follows: 1) One hundred ninety cases were investigated bronchoscopically due to suspicion of pulmonary tuberculosis with sputum negative smear and 92 cases were confirmed to be pulmonary tuberculosis. 2) Out of 91 cases examined by bronchial aspirate and 46 cases by bronchial washing, smear positivity was 20.9% and 23.9% and culture positivity was 58.2% and 84.8%, respectively. Transbronchial lung biopsy showed positive findings of tuberculosis in 75.8% out of 33 specimens. 3) Out of 88 sputa taken before bronchoscopy and 50 sputa after bronchoscopy, smear positivity was 0% and 12%, and culture positivity was 54.5% and 40% respectively. Gastric lavage culture positivity was 29.4% in 17 cases examined. 4) Diagnosis of tuberculosis was made rapidly in 28 cases (30.4%) by smear positive results of bronchial aspirate, bronchial washing and sputa after bronchoscopy, and relatively rapidly in 20 cases (21.7%) by transbronchial lung biopsy.
|
['Biopsy', 'Bronchoalveolar Lavage Fluid', 'Bronchoscopy', 'Humans', 'Lung', 'Predictive Value of Tests', 'Sputum', 'Tuberculosis, Pulmonary']
| 2,313,959
|
[['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E05.927.100.500'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['A12.200.808'], ['C01.150.252.410.040.552.846.899', 'C01.748.939', 'C08.381.922', 'C08.730.939']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Diseases [C]']
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
|
Estrogens, progestins, and coronary artery reactivity in atherosclerotic monkeys.
|
It has been known for many years that sex hormones modulate vasodilator responses of arteries supplying the uterus with blood. Recently, it has been shown that sex hormones such as estrogen modulate vasomotor responses of other arteries, including coronary arteries. It is thought that modulation of vasodilator and constrictor responses of coronary arteries may be one mechanism by which estrogen affects the risk of coronary heart disease. Although several studies have examined the effects (and potential mechanisms) of estrogen on vasodilator responses of nonatherosclerotic arteries, few have focused on estrogen's effects on atherosclerotic coronary arteries. In studies of ovariectomized atherosclerotic female cynomolgus monkeys, both long-term (2 years) and short-term (20 min) estradiol treatment augments dilator responses to acetylcholine, but not nitroglycerin. Presumably, this indicates an effect of estradiol on endothelium-mediated dilator responses of coronary arteries. Addition of the progestin medroxyprogesterone acetate diminishes the beneficial effect of conjugated equine estrogens on these dilator responses. This is significant because a progestin is usually added to estrogen replacement to reduce the risk of endometrial and breast cancer associated with unopposed estrogen therapy. However, it would seem that not all progestins act similarly on vascular reactivity. Studies in monkeys indicate that addition of progesterone or the progestin medroxyprogesterone acetate does not diminish the beneficial effects of estrogen on coronary dilator responses. Thus it would appear that different estrogen/progestin combinations may affect vascular reactivity in different manners, There is also an effort being made to examine the potential of different kinds of estrogens on cardiovascular risk. Studies in monkeys indicate that one of the estrogens found in conjugated equine estrogens (17 alpha-dihydroequilenin) has estrogen effects on vascular reactivity without having detrimental effects on uterine pathology. The isoflavones "plant estrogens" found in soy protein also have estrogenic effects on vascular reactivity and inhibition.
|
['Acetylcholine', 'Animals', 'Coronary Artery Disease', 'Estrogens', 'Female', 'Macaca fascicularis', 'Male', 'Medroxyprogesterone Acetate', 'Megestrol', 'Norpregnadienes', 'Premenopause', 'Progestins', 'Sex Characteristics', 'Vasodilation', 'Vasodilator Agents']
| 9,699,876
|
[['D02.092.211.111'], ['B01.050'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['D27.505.696.399.472.277'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['D04.210.500.745.745.654.829.395.700.500'], ['D04.210.500.745.432.531'], ['D04.210.500.668.651.443'], ['G08.686.157.500.812', 'G08.686.841.249.500.812'], ['D27.505.696.399.472.858'], ['G08.686.815'], ['G09.330.380.928'], ['D27.505.954.411.918']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]']
| 0
| 1
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Effects of childbirth on podocyturia in women with normotensive, uncomplicated pregnancies.
|
Changes in hemodynamics and blood pressure occur shortly before and after childbirth regardless of the mode of delivery. This study aimed to test the hypothesis that parturition induces a temporal increase in podocyturia monitored by podocyte-specific protein podocin mRNA expression levels (Pod-mRNA). A total of 105 urine specimens, consisting of 43 and 62 from 18 and 20 otherwise healthy women with vaginal delivery (VD) and elective cesarean delivery (ECS), respectively, were studied. Determination of urine protein and creatinine (Cr) concentrations and quantitative analyses of Pod-mRNA, nephrin mRNA (Nep-mRNA), synaptopodin mRNA (Syn-mRNA), and aquaporin 2 mRNA expression were performed using RT-PCR in pelleted urine samples. Levels of mRNA expression were corrected by urine Cr concentration. Podocyturia increased significantly, concomitant with a significantly decreased Nep:Pod-mRNA ratio (NPR) in the urine, collected immediately before or after childbirth regardless of the delivery mode compared with urine collected before commencement of labor or on postpartum day 3 or later. Podocyturia was significantly negatively correlated with NPR [correlation coefficient (r) = -0.614/-0.750 for VD/ECS women, respectively], as well as the Syn:Pod-mRNA ratio. Systolic blood pressure exceeded 140 mmHg during labor in 50% of VD women, and mean arterial pressure was significantly positively correlated with podocyturia during labor in VD women (r = 0.733). Thus parturition induces a transient increase in urine podocytes with reduced Nep- and Syn-mRNA expressions. Glomerular podocytes with reduced Nep- and Syn-mRNA levels were suggested to be likely to detach from the glomerular basement membrane around childbirth.
|
['Adult', 'Aquaporin 2', 'Arterial Pressure', 'Cesarean Section', 'Creatinine', 'Elective Surgical Procedures', 'Female', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Membrane Proteins', 'Microfilament Proteins', 'Middle Aged', 'Parturition', 'Podocytes', 'Pregnancy', 'Proteinuria', 'RNA, Messenger', 'Time Factors', 'Urine', 'Young Adult']
| 28,274,928
|
[['M01.060.116'], ['D12.776.157.530.400.500.040.437', 'D12.776.543.550.450.730.040.437', 'D12.776.543.585.400.730.040.530'], ['G09.330.380.076.347'], ['E04.520.252.500'], ['D03.383.129.308.207'], ['E04.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ['D12.776.543'], ['D05.750.078.730', 'D12.776.220.525'], ['M01.060.116.630'], ['G08.686.784.769.490'], ['A05.810.453.324.359.372.650', 'A05.810.453.736.520.720', 'A11.436.720'], ['G08.686.784.769'], ['C12.777.934.734', 'C13.351.968.934.734', 'C23.888.942.750'], ['D13.444.735.544'], ['G01.910.857'], ['A12.207.927'], ['M01.060.116.815']]
|
['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]']
| 1
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Treating systolic hypertension in the very elderly with valsartan-hydrochlorothiazide vs. either monotherapy: ValVET primary results.
|
This 16-week trial investigated the efficacy and safety of single-pill valsartan/hydrochlorothiazide (HCTZ) vs. the individual components in patients 70 years and older with systolic hypertension. Patients were randomized to valsartan/HCTZ 160/12.5 mg (n=128), HCTZ 12.5 mg (n=128), or valsartan 160 mg (n=128) for 4 weeks. Patients whose blood pressure (BP) was ?140/90 mm Hg at weeks 4, 8, or 12 were up-titrated to a maximum of valsartan/HCTZ 320/25 mg. Week 4 systolic BP reduction (primary efficacy outcome) was greater with valsartan/HCTZ than valsartan (-17.3 mm Hg vs. -8.6 mm Hg, P <.0001) but only marginally greater than HCTZ (-13.6 mm Hg, P =.096). Median time to BP control was shorter with valsartan/HCTZ (4 weeks) vs HCTZ (8 weeks, P<.05) or valsartan (12 weeks, P<.0001). Thiazide monotherapy was more effective than angiotensin receptor blocker monotherapy (by about 5 mm Hg), but greater antihypertensive efficacy was achieved by initiating treatment with combination valsartan/HCTZ in the elderly.
|
['Aged', 'Aged, 80 and over', 'Antihypertensive Agents', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Drug Therapy, Combination', 'Female', 'Humans', 'Hydrochlorothiazide', 'Hypertension', 'Male', 'Systole', 'Tetrazoles', 'Treatment Outcome', 'Valine', 'Valsartan']
| 21,974,759
|
[['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.411.162'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.886.590.700.135.261.476', 'D02.886.655.500.261.476', 'D03.633.100.174.261.476'], ['C14.907.489'], ['G09.330.580.880', 'G11.427.494.570.880'], ['D03.383.129.617'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['D12.125.070.950', 'D12.125.142.930'], ['D03.383.129.617.850', 'D12.125.070.950.550', 'D12.125.142.930.500']]
|
['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]']
| 0
| 1
| 1
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
[Mexico recovers leadership on regulation of biosimilar biotech drugs].
|
Amid the epidemiological transition that Mexico is currently experiencing, an adequate access to biotech medicines is becoming very important. However, these medicines also involve new challenges for the sanitary authorities, given their higher complexity in structure and function than conventional chemical drugs. Consequently, it has been necessary to update the Mexican legal framework, which has placed Mexico at the forefront in this sector. This article describes briefly what biotech drugs are, why it has been necessary to regulate them differently, the evolution of the regulatory framework in Mexico, and the general features of the new system.
|
['Biological Products', 'Biosimilar Pharmaceuticals', 'Drug Industry', 'Leadership', 'Mexico']
| 22,367,313
|
[['D20.215'], ['D20.215.261'], ['J01.576.655.750'], ['F01.752.609'], ['Z01.107.567.589']]
|
['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]']
| 0
| 0
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 1
| 0
| 0
| 0
| 1
|
Salivary composition in diabetic patients.
|
Salivary composition and flow rate were examined in 35 patients with insulin-dependent diabetes mellitus (IDDM) and compared to 31 healthy controls. Significantly lower whole-saliva flow rate was observed in the IDDM patients, but was not correlated with the subjective complaint of xerostomy. Glucose concentration was significantly higher in the parotid saliva of the IDDM patients. Potassium concentration was significantly higher in whole and parotid, resting and stimulated saliva, as was total protein concentration in resting whole and in stimulated parotid saliva of the diabetics. No significant difference between diabetics and healthy controls was found in sodium and IgA concentration or in amylase activity. The significantly higher glucose, lower flow rate, and higher potassium and protein concentrations indicate that salivary glands are affected in IDDM. The subjective complaint of dry mouth, often present in diabetics, while not correlated with salivary flow rate, might reflect qualitative changes in salivary composition and/or altered mucosal perception. Salivary glucose concentration, although significantly higher in the diabetics, was not significantly correlated with serum glucose, preventing the use of saliva for monitoring blood sugar.
|
['Amylases', 'Blood Glucose', 'Diabetes Mellitus, Type 1', 'Glucose', 'Humans', 'Immunoglobulin A', 'Parotid Gland', 'Potassium', 'Reference Values', 'Saliva', 'Salivary Proteins and Peptides', 'Sodium']
| 2,458,369
|
[['D08.811.277.450.066'], ['D09.947.875.359.448.500'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.026', 'D12.776.124.790.651.114.619.026', 'D12.776.377.715.548.114.619.026'], ['A03.556.500.760.464', 'A10.336.779.464', 'A14.549.760.464'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['E05.978.810'], ['A12.200.666'], ['D12.644.848', 'D12.776.850'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850', 'D01.552.547.725']]
|
['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Rapid gas-liquid chromatographic method for determining residues of ethephon (2-chloroethyl phosphonic acid) in tomatoes.
|
A rapid method is described for the determination of the growth regulator ethephon (2-chloroethyl phosphonic acid) in tomatoes. Samples are extracted with ethyl acetate. The extract is methylated, decolorized with carbon, and analyzed by gas-liquid chromatography on a column packed with 15% QF-1/10% DC-200 on Chromosorb W (HP). A flame photometric detector is used. Recoveries from tomatoes fortified with 0.1-11.0 ppm ethephon were 78-98%. The sensitivity of this method is about 0.1 ppm.
|
['Chromatography, Gas', 'Chromatography, Liquid', 'Ethyl Chloride', 'Organophosphorus Compounds', 'Plant Growth Regulators', 'Vegetables']
| 965,343
|
[['E05.196.181.349'], ['E05.196.181.400'], ['D02.455.526.439.447'], ['D02.705'], ['D27.505.696.377.760'], ['B01.650.160.956', 'B01.650.510.956', 'G07.203.300.850', 'J02.500.850']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]']
| 0
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
|
Myristoylation-dependent replication and assembly of human immunodeficiency virus 1.
|
Covalent linkage of myristic acid to the N-terminal glycine residue of Pr55gag, the precursor of the major structural proteins of human immunodeficiency virus 1 (HIV-1), facilitates an essential step in virus assembly and propagation. Substitution of the myristoyl-acceptor glycine with alanine, in a functional clone of HIV-1, eliminates virus replication. Complementation of this defect, in trans, restores infectious particle production. The nonmyristoylated (myr-) gag precursor accumulates in infected cells and is not processed into the mature capsid components of the intact virion. However, myr- Pr55gag can be processed by purified HIV protease in vitro, demonstrating that the myristoyl moiety is not required for cleavage by the protease. Myristoylation of Pr55gag is not necessary for localization but is required for stable membrane association and assembly of HIV-1.
|
['Alanine', 'Base Sequence', 'Cell Fractionation', 'Cell Line', 'Gene Products, gag', 'Glycine', 'HIV-1', 'HeLa Cells', 'Humans', 'Kinetics', 'Molecular Sequence Data', 'Mutation', 'Myristic Acid', 'Myristic Acids', 'Oligonucleotide Probes', 'Protein Processing, Post-Translational', 'Subcellular Fractions', 'Transfection', 'Virus Replication']
| 2,405,382
|
[['D12.125.042'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.242.251'], ['A11.251.210'], ['D12.776.775.330', 'D12.776.964.775.350', 'D12.776.964.970.600.850.350'], ['D12.125.481'], ['B04.820.650.589.650.350.400'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['L01.453.245.667'], ['G05.365.590'], ['D10.251.640.630'], ['D10.251.640'], ['D13.444.600.601', 'D27.505.259.750.600.650', 'D27.720.470.530.600.650'], ['G02.111.660.871.790.600', 'G02.111.691.600', 'G03.734.871.790.600', 'G05.308.670.600'], ['A11.284.835'], ['E05.393.350.810', 'G05.728.860'], ['G06.920.925']]
|
['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 1
| 0
| 0
| 0
|
[Smarter medicine in ambulatory care : beliefs and practices of family doctors and training of future clinicians].
|
Following an American and then international initiative, the Swiss Society of Internal Medicine launched the « Smarter Medicine » campaign in 2014 with five recommendations of activities to be avoided, focusing on low back pain, antibiotic prescriptions, pre-operative chest x-rays, prostate cancer screening and treatment with proton pump inhibitors. In 2016, 69 % of family physicians reported that they knew the recommendations and levels of agreement were very high. However, physicians reported differences between recommendations in how often they are followed in practice, and there remains room for improvement. We need to put in place training programs at the pre- and post-graduate levels, as well as continuing medical education. It would also be useful to educate patients.
|
['Ambulatory Care', 'Attitude of Health Personnel', 'Education, Medical', 'Family Practice', 'Forecasting', 'Humans', "Practice Patterns, Physicians'"]
| 28,704,010
|
[['E02.760.106', 'N02.421.585.106'], ['F01.100.050', 'N05.300.100'], ['I02.358.399'], ['H02.403.340.500'], ['I01.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.374.577', 'N05.300.625']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Organisms [B]']
| 0
| 1
| 0
| 0
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 1
| 0
|
The protective role of epithelium-derived nitric oxide in isolated bovine trachea.
|
Airway epithelial cells from bovine airways can release relaxant factors such as nitric oxide (NO) and prostaglandin E(2) and the removal of airway epithelium results in an increased responsiveness of smooth muscle to spasmogen stimuli. In this study, we assessed whether or not epithelial NO modulates the contractile response of bovine trachea in vitro.Cumulative concentration-response curves to acetylcholine (ACh), histamine (Hist) and 5-hydroxytryptamine (5-HT) were obtained in both intact and epithelium denuded tracheal strips in the presence of indomethacin (10 microM).In intact, but not in epithelium denuded strips, preincubation with the NO synthase inhibitor L-N((G))-Nitro-arginine methyl ester (L-NAME), but not with D-NAME, shifted to the left the concentration-response curve to ACh (pD(2) values in the absence and in the presence of L-NAME were 3.47+/-0.1 and 4.60+/-0.1, respectively; P<0.05) and to Hist (pD(2) in the absence and in the presence of L-NAME: 3.89+/-0.1 and 4.54+/-0.1, respectively; P<0.05). This effect was reversed by L-arginine (1mM), but not by D-arginine. The contractile response to 5-HT was not affected by L-NAME in either intact or epithelium denuded strips. These data suggest that NO is an epithelial relaxant factor modulating airway cholinergic and histaminergic contraction of bovine trachea and that the activation of the epithelial NO synthase is a mediator-specific process.
|
['Acetylcholine', 'Animals', 'Arginine', 'Cattle', 'Enzyme Inhibitors', 'Epithelium', 'Histamine', 'In Vitro Techniques', 'Muscle Contraction', 'Muscle, Smooth', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Serotonin', 'Statistics as Topic', 'Trachea']
| 12,220,940
|
[['D02.092.211.111'], ['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['B01.050.150.900.649.313.500.380.271'], ['D27.505.519.389'], ['A10.272'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373', 'D23.469.050.300'], ['E05.481'], ['G11.427.494'], ['A02.633.570', 'A10.690.467'], ['D12.125.068.050.525', 'D12.125.095.104.525'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['D08.811.682.664.500.772'], ['D02.092.211.215.801.852', 'D03.633.100.473.914.814', 'D23.469.050.650'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.850.520.830'], ['A04.889']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 1
| 0
|
Interventional cardiac catheterization in infants weighing less than 2500 g.
|
The aim of our study was to share our clinical experience regarding cases of interventional cardiac catheterization in low-weight infants. We retrospectively reviewed all interventional catheterizations performed in infants weighing 2500 g or less between March 2001 and October 2012. Twenty patients were included in the study. The procedures included balloon atrial septostomy in 8 patients, balloon pulmonary valvuloplasty in 7 patients, balloon aortic valvuloplasty in 3 patients and balloon angioplasty for coarctation in 2 patients. The mean age at catheterization was 11.9 ± 9.6 days (range, 1 to 31 days) and the mean weight, 2038 ± 480 g (range, 1100 to 2500 g). The mean procedure time was 80.3 ± 32 minutes, and the mean fluoroscopy time was 17.5 ± 12 minutes. Only two patients had no benefit from the intervention. One patient died at day 4 after catheterization, due to sepsis. Complications occurred in 3 patients: one patient developed atrial flutter and respiratory arrest, one patient developed apnea episodes, and one patient developed anemia that required transfusion. In conclusion, although studies investigating complications related to invasive cardiac catheterization in infants weighing less than 2500 g have reported increased complication rates, such complications were less likely to result in permanent sequelae. We did not observe significant complications related to the procedure; therefore, we would like to suggest that invasive cardiac catheterization can appropriately be performed in low-weight infants.
|
['Angioplasty, Balloon', 'Balloon Valvuloplasty', 'Cardiac Catheterization', 'Female', 'Heart Defects, Congenital', 'Humans', 'Infant, Low Birth Weight', 'Infant, Newborn', 'Male', 'Operative Time', 'Retrospective Studies']
| 26,690,593
|
[['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['E02.148.108', 'E05.157.125'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520.460'], ['M01.060.703.520'], ['E04.614.374.500', 'N02.421.585.753.374.500'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]']
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
A genome-wide study of modern-day Tuscans: revisiting Herodotus's theory on the origin of the Etruscans.
|
BACKGROUND: The origin of the Etruscan civilization (Etruria, Central Italy) is a long-standing subject of debate among scholars from different disciplines. The bulk of the information has been reconstructed from ancient texts and archaeological findings and, in the last few years, through the analysis of uniparental genetic markers.METHODS: By meta-analyzing genome-wide data from The 1000 Genomes Project and the literature, we were able to compare the genomic patterns (>540,000 SNPs) of present day Tuscans (N = 98) with other population groups from the main hypothetical source populations, namely, Europe and the Middle East.RESULTS: Admixture analysis indicates the presence of 25-34% of Middle Eastern component in modern Tuscans. Different analyses have been carried out using identity-by-state (IBS) values and genetic distances point to Eastern Anatolia/Southern Caucasus as the most likely geographic origin of the main Middle Eastern genetic component observed in the genome of modern Tuscans.CONCLUSIONS: The data indicate that the admixture event between local Tuscans and Middle Easterners could have occurred in Central Italy about 2,600-3,100 years ago (y.a.). On the whole, the results validate the theory of the ancient historian Herodotus on the origin of Etruscans.
|
['DNA, Mitochondrial', 'Emigration and Immigration', 'Genetics, Population', 'Genome-Wide Association Study', 'Italy']
| 25,230,205
|
[['D13.444.308.283.225'], ['I01.240.600.525.500', 'N01.224.625.525.500', 'N06.850.505.400.700.525.500'], ['H01.158.273.343.335'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N06.850.520.470.500'], ['Z01.542.489']]
|
['Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]']
| 0
| 0
| 0
| 1
| 1
| 0
| 0
| 1
| 1
| 0
| 0
| 0
| 1
| 1
|
Description and evaluation of structured speaking and listening activities for hearing-impaired adults.
|
This study was designed to evaluate improvement in word comprehension, pronunciation, and auditory discrimination as a result of structured group experience in speaking and listening. Subjects included 75 college students with hearing impairment and auditory discrimination for speech. Subjects were divided into three groups matched on the basis of hearing characteristics. Groups A and B received 20 hours of instruction over a 10-wk interval. Group A was evaluated relative to word comprehension, word usage in writing, and pronunciation. Group B was evaluated relative to auditory discrimination before and after training. Group C (control) did not receive training but auditory discrimination was evaluated over the 10-wk interval. Significant improvements in word comprehension, word usage in writing, pronunciation, and in auditory discrimination were achieved as a result of training. No significant change in auditory discrimination was observed in the control group.
|
['Adult', 'Evaluation Studies as Topic', 'Hearing Disorders', 'Humans', 'Speech Perception', 'Speech Therapy']
| 438,363
|
[]
|
[]
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Y-chromosomal DNA haplotypes in infertile European males carrying Y-microdeletions.
|
We have determined Y-chromosomal DNA haplotypes in 73 infertile European males carrying Y microdeletions and compared them with the haplotypes of 299 infertile males lacking microdeletions. Chromosomes were typed with a set of 11 binary Y markers, which identified 8 haplogroups in the sample. Haplogroup frequencies were compared between 3 microdeletion classes and the non-deleted infertile males. Deletions arise on many different haplotypic backgrounds. No statistically significant differences in frequency were seen, although the small number of AZFa deletions lay predominantly on one branch of the Y haplotype tree.
|
['DNA', 'Europe', 'Gene Deletion', 'Gene Frequency', 'Haplotypes', 'Humans', 'Infertility, Male', 'Male', 'Phylogeny', 'Y Chromosome']
| 11,097,432
|
[['D13.444.308'], ['Z01.542'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.330'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['A11.284.187.865.983', 'G05.360.162.865.983']]
|
['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]', 'Anatomy [A]']
| 1
| 1
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 1
| 0
| 0
| 1
|
Derivation of indices of left ventricular contractility in the setting of continuous-flow left ventricular assist device support.
|
It is important to accurately monitor residual cardiac function in patients under long-term continuous-flow left ventricular assist device (cfLVAD) support. Two new measures of left ventricular (LV) chamber contractility in the cfLVAD-unloaded ventricle include IQ, a regression coefficient between maximum flow acceleration and flow pulsatility at different pump speeds; and K, a logarithmic relationship between volumes moved in systole and diastole. We sought to optimize these indices. We also propose RIQ, a ratio between maximum flow acceleration and flow pulsatility at baseline pump speed, as an alternative to IQ. Eleven patients (mean age 49 ± 11 years) were studied. The K index was derived at baseline pump speed by defining systolic and diastolic onset as time points at which maximum and minimum volumes move through the pump. IQ across the full range of pump speeds was markedly different between patients. It was unreliable in three patients with underlying atrial fibrillation (coefficient of determination R(2) range: 0.38-0.74) and also when calculated without pump speed manipulation (R(2) range: 0.01-0.74). The K index was within physiological ranges, but poorly correlated to both IQ (P = 0.42) and RIQ (P = 0.92). In four patients there was excellent correspondence between RIQ and IQ, while four other patients showed a poor relationship between these indices. As RIQ does not require pump speed changes, it may be a more clinically appropriate measure. Further studies are required to determine the validity of these indices.
|
['Adult', 'Female', 'Heart Failure', 'Heart Ventricles', 'Heart-Assist Devices', 'Humans', 'Male', 'Middle Aged', 'Muscle Contraction', 'Pulsatile Flow', 'Ventricular Function, Left']
| 24,660,889
|
[['M01.060.116'], ['C14.280.434'], ['A07.541.560'], ['E04.050.430', 'E07.695.300.300', 'E07.858.082.374.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G11.427.494'], ['G01.482.620', 'G09.330.380.630.555'], ['G09.330.955.800']]
|
['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]']
| 1
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Pure Leydig cell tumour (hilus cell) of the ovary: a rare cause of virilization after menopause.
|
A 58-year-old postmenopausal woman with high plasma testosterone levels and virilization, as demonstrated by hirsutism and alopecia, is presented. Urinary 17-ketosteroids and 17-hydroxycorticosteroids as well as the computed axial tomography scan of the adrenal glands were normal. Although no pelvic mass was detected by sonography or pelvic examination, the patient was found to have small pure Leydig cell tumour of the left ovary. Following total abdominal hysterectomy and bilateral salpingo-oophorectomy, the patient had regression of the hirsutism, and the plasma testosterone dropped to normal level.
|
['17-alpha-Hydroxyprogesterone', 'Adrenocorticotropic Hormone', 'Androgens', 'Androstenedione', 'Androsterone', 'Circadian Rhythm', 'Dehydroepiandrosterone', 'Female', 'Humans', 'Hydrocortisone', 'Leydig Cell Tumor', 'Middle Aged', 'Ovarian Neoplasms', 'Postmenopause', 'Testosterone', 'Time Factors', 'Virilism']
| 9,286,731
|
[['D04.210.500.745.745.654.829.395.400', 'D06.472.334.851.687.750.478.400'], ['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['D27.505.696.399.472.161'], ['D04.210.500.054.079.329', 'D04.210.500.578.502.112', 'D06.472.040.502.112', 'D06.472.334.851.968.875'], ['D04.210.500.054.040.129', 'D04.210.500.578.502.195', 'D06.472.040.502.195', 'D06.472.334.851.968.937'], ['G07.180.562.190'], ['D04.210.500.054.079.429.625', 'D04.210.500.578.502.400', 'D06.472.040.502.400', 'D06.472.334.851.968.952'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['C04.557.475.750.847.249', 'C04.588.322.762.500.249', 'C04.588.945.440.915.500.249', 'C12.294.260.937.500.249', 'C12.758.409.937.500.249', 'C19.344.762.500.249', 'C19.391.829.782.500.249'], ['M01.060.116.630'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'], ['G08.686.157.500.625', 'G08.686.841.249.500.625'], ['D04.210.500.054.079.429.824', 'D06.472.334.851.968.984'], ['G01.910.857'], ['C23.888.971']]
|
['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]']
| 0
| 1
| 1
| 1
| 0
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
An approach to the patient with hirsutism.
|
Hirsutism is a common endocrinological complaint. The causes of this complaint can vary from dissatisfaction with a normal pattern of hair growth on the one hand, to the first clinical manifestation of androgen overproduction by an adrenal adenocarcinoma on the other. The purpose of this short review is to reexamine the physiology of hair growth in normal women, identify the common abnormal patterns, and explore the differential diagnosis associated with each. An approach to working through the differential diagnosis will be described, and the commonly available treatment modalities for the various forms of hirsutism will be examined in terms of risk and benefit. The review is written from the point of view of the physician and the most efficient, cost effective, and safe clinical approach to the patient with the problem.
|
['Adolescent', 'Adult', 'Aged', 'Androgen Antagonists', 'Child', 'Cosmetic Techniques', 'Diagnosis, Differential', 'Electrolysis', 'Female', 'Hair', 'Hair Removal', 'Hirsutism', 'Humans', 'Laser Therapy', 'Middle Aged', 'Ovary', 'Terminology as Topic', 'Women', 'Young Adult']
| 22,962,669
|
[['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D06.347.065', 'D27.505.696.399.450.065'], ['M01.060.406'], ['E02.218'], ['E01.171'], ['E05.301.250'], ['A17.360'], ['E02.218.372'], ['C17.800.329.750', 'C23.888.971.468'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['M01.060.116.630'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['L01.559.598.400'], ['M01.975'], ['M01.060.116.815']]
|
['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]']
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
| 0
|
Antirheumatic drug use and the risk of acute myocardial infarction.
|
OBJECTIVE: To assess the risk of acute myocardial infarction (AMI) associated with the use of disease-modifying antirheumatic drugs (DMARDs) and other medications commonly used in rheumatoid arthritis (RA).METHODS: We conducted a nested case-control analysis within a cohort of subjects with RA, observed between 1999 and 2003, identified from the PharMetrics claims database. For each first AMI hospitalization identified during followup, 10 controls matched on sex, age, and time of study entry were randomly selected from the cohort. Conditional logistic regression was used to estimate the rate ratio (RR) of AMI associated with the current use of anti-RA therapy, as measured from dispensed prescriptions, after adjustment for AMI risk factors.RESULTS: The cohort included 107,908 subjects (average age 54 years at cohort entry). During followup, 558 AMI cases occurred (3.4 per 1,000 per year). AMI rate was significantly decreased with the current use of any DMARD (adjusted RR 0.80, 95% confidence interval [95% CI] 0.65-0.98). This effect was consistent across all DMARDs, including methotrexate (RR 0.81, 95% CI 0.60-1.08), leflunomide (RR 0.28, 95% CI 0.12-0.65), and other traditional DMARDs (RR 0.67, 95% CI 0.46-0.97), but not biologic agents (RR 1.30, 95% CI 0.92-1.83). AMI rate increased with the use of glucocorticoids (RR 1.32, 95% CI 1.02-1.72) but not with nonselective nonsteroidal antiinflammatory drugs (RR 1.05, 95% CI 0.81-1.36) or cyclooxygenase 2 (COX-2) inhibitors (RR 1.11, 95% CI 0.87-1.43).CONCLUSION: DMARD use is associated with a reduction in AMI risk in patients with RA. No risk increase was found with the COX-2 inhibitors in this population.
|
['Aged', 'Antirheumatic Agents', 'Arthritis, Rheumatoid', 'Case-Control Studies', 'Cohort Studies', 'Female', 'Humans', 'Isoxazoles', 'Leflunomide', 'Male', 'Methotrexate', 'Middle Aged', 'Myocardial Infarction', 'Random Allocation', 'Treatment Outcome']
| 16,874,796
|
[['M01.060.116.100'], ['D27.505.954.329'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.385'], ['D03.383.129.385.475'], ['D03.633.100.733.631.192.500'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]']
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Evaluation of locked plate in the osteosynthesis of fractures in osteoporotic bones.
|
BACKGROUND: The use of conventional dynamic compression plates (DCPs) in osteoporotic bones is associated with higher chances of implant failure. The advent and use of locking combi-plates have ensured a stable construct during osteosynthesis of fractures in osteoporotic bones.OBJECTIVES: The study aims to assess the outcome of use of locking combi-plates in the management of fractures in osteoporotic bones in our environment.MATERIALS AND METHODS: Cases of patients with nonunion and localized osteoporosis from January 2014 to December 2014 that were managed with locked combi-plates were reviewed. Outcome was assessed by time to healing, stability of implant construct after 6 and 12 months.RESULTS: There were 10 patients with mean age of 47.4 ± 12.63 years. There were 9 males and 1 female, and road traffic crashes were the mechanism of injury in 90% (n = 9) and gunshot injuries in 10% (n = 1). Atrophic nonunion was the most common indication for osteosynthesis with 80%, followed by fibrous nonunion with 10.0%. The humerus was the most common long bone involved with 50%. Locked broad DCP was used in 62.5%, and the duration between initial injury and surgery was 6 and 48 months, with an average of 17.5 months. The outcome was such that 90% healed after 12 months on follow-up while one case had the implant backing out and delay union at 6 months.CONCLUSION: The use of locked plate in the management of nonunion in the presence of osteoporosis ensures stable fixation construct and healing. Contexte: L'utilisation de plaques de compression dynamiques conventionnelles dans les os ost?oporotiques est associ?e ? des chances plus ?lev?es de d?faillance de l'implant. L'av?nement et l'utilisation de combi-plaques de verrouillage ont assur? une construction stable lors de l'ost?osyntheis de fractures dans les os ost?oporotiques. Objectifs: L'?tude vise ? ?valuer le r?sultat de l'utilisation de combi-plaques de verrouillage dans la gestion des fractures dans les os ost?oporotiques dans notre environnement. M?thodologie: Les cas de patients atteints d'ost?oporose non syndiqu?e et localis?e de janvier 2014 ? d?cembre 2014 qui ont ?t? g?r?s avec des combi-plaques verrouill?es ont ?t? examin?s. Le r?sultat a ?t? ?valu? par le temps de gu?rison, la stabilit? de la construction d'implant apr?s 6 et 12 mois. R?sultats: il y avait 10 patients avec un ?ge moyen de 47,4 12,63. Il y avait 9 hommes et 1 accident de la route et de la route ?tait le m?canisme de la blessure dans 90% (n = 9) et les blessures par balle dans 10% (n = 1). La non-union atrophique ?tait l'indication la plus courante pour l'ost?osynth?se avec 80%, suivie d'une non-union fibreuse avec 10,0%. L'hum?rus ?tait l'os le plus fr?quent impliqu? avec 50%. La plaque de compression dynamique bloqu?e (DCP) a ?t? utilis?e ? 62,5% et la dur?e entre la blessure initiale et la chirurgie ?tait de 6 et 48 mois avec une moyenne de 17,5 mois. Le r?sultat ?tait tel que 90% ont ?t? gu?ris apr?s 12 mois de suivi, tandis que 1 cas avait l'implantation de l'implant et retard? l'union ? 6 mois.CONCLUSION: L'utilisation de la plaque verrouill?e dans la gestion de la non-union en pr?sence d'ost?oporose assure une construction stable de fixation et une gu?rison.
|
['Adult', 'Aged', 'Bone Plates', 'Female', 'Fracture Fixation, Internal', 'Fracture Healing', 'Fractures, Bone', 'Humans', 'Male', 'Middle Aged', 'Osteoporosis', 'Treatment Outcome']
| 28,671,153
|
[['M01.060.116'], ['M01.060.116.100'], ['E07.695.370.374', 'E07.858.442.660.460.374', 'E07.858.690.725.460.374'], ['E04.555.300.300'], ['G16.762.891.500'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.116.198.579', 'C18.452.104.579'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]']
| 0
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Controlled synthesis of 3D multi-compartmental particles with centrifuge-based microdroplet formation from a multi-barrelled capillary.
|
Controlled synthesis of micro multi-compartmental particles using a centrifuge droplet shooting device (CDSD) is reported. Sodium alginate solutions introduced in a multi-barreled capillary form droplets at the capillary orifice under ultrahigh gravity and gelify in a CaCl(2) solution. The size, shape, and compartmentalization of the particles are controlled. Co-encapsulation of Jurkat cells and magnetic colloids into Janus particles is demonstrated. The Janus particles present sensitive reaction toward magnetic fields, while the viability of the encapsulated cells is 91%.
|
['Centrifugation', 'Microtechnology', 'Particle Size']
| 22,311,473
|
[['E05.181'], ['H01.570', 'J01.897.520.500'], ['G02.712']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]']
| 0
| 0
| 0
| 0
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
|
Preoperative and longitudinal serum levels of CA 125 and CA 15.3 in patients with breast cancer.
|
Serum levels of ovarian carcinoma antigen (CA 125) and breast carcinoma antigen (CA 15.3) were determined in 237 patients with breast carcinoma, 121 before any therapy and 116 after initial treatment, during uneventful follow-up or at the time of relapse. The aim was to assess how often the CA 125 test failed, i.e., was false-negative in patients in whom the CA 15.3 test was true-positive and, more important, whether it gave diagnostic information in patients in whom the CA 15.3 test failed. Before surgery or other initial therapy, serum CA 125 and CA 15.3 gave similar information in 85.1 percent of the patients: true-positive in 4.1 percent and false negative in 81.0 percent: CA 125 gave less information in 13.2 percent; and more information in only 1.7 percent. During follow-up, serum CA 125 and CA 15.3 gave similar information in 73.3 percent of the patients: true-positive (i.e., rising persistently from a nadir or elevated above 65 U/ml) in 23.3 percent, true-negative in 36.2 percent, and false-negative in 13.8 percent; CA 125 gave less information in 25.0 percent: false negative in 22.4 percent and false-positive in 2.6 percent; and more information in only 1.7 percent. Therefore, the CA 125 test appears useless for staging and is redundant when the CA 15.3 test is employed, for management of patients with breast cancer.
|
['Antigens, Tumor-Associated, Carbohydrate', 'Biomarkers, Tumor', 'Breast Neoplasms', 'Carcinoma', 'False Negative Reactions', 'Follow-Up Studies', 'Humans', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Preoperative Care', 'Retrospective Studies']
| 2,768,892
|
[['D23.050.285.050', 'D23.050.550.325', 'D23.101.140.075'], ['D23.101.140'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200'], ['E01.354.340'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.655', 'C23.550.727.655'], ['E01.789.625'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825']]
|
['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]']
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
|
Treatment of life-threatening primary pulmonary hemosiderosis with cyclophosphamide.
|
This report describes a five-year-old boy with severe pulmonary hemorrhage caused by primary pulmonary hemosiderosis with cow's milk sensitivity. After failing to respond to corticosteroids and azathioprine, he dramatically improved after being given cyclophosphamide. He worsened after discontinuation of cyclophosphamide on two occasions and improved significantly with its reinstitution. Cyclophosphamide was continued for 14 months without further bleeding or adverse effects. The patient has remained in remission for nearly five years. Cyclophosphamide may be a life-saving alternative therapy for refractory pulmonary hemorrhage with pulmonary hemosiderosis.
|
['Child, Preschool', 'Cyclophosphamide', 'Hemoptysis', 'Hemosiderosis', 'Humans', 'Lung Diseases', 'Male', 'Milk Hypersensitivity', 'Syndrome']
| 1,516,434
|
[['M01.060.406.448'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['C08.381.348', 'C23.550.414.896', 'C23.888.852.430'], ['C18.452.565.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['C20.543.480.370.500'], ['C23.550.288.500']]
|
['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]']
| 0
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1.
|
STAM1, a member of the STAM (signal transducing adapter molecule) family, has a unique structure containing a Src homology 3 domain and ITAM (immunoreceptor tyrosine-based activation motif). STAM1 was previously shown to be associated with the Jak2 and Jak3 tyrosine kinases and to be involved in the regulation of intracellular signal transduction mediated by interleukin-2 (IL-2) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in vitro. Here we generated mice lacking STAM1 by using homologous recombination with embryonic stem cells. STAM1(-/-) mice were morphologically indistinguishable from their littermates at birth. However, growth retardation in the third week after birth was observed for the STAM1(-/-) mice. Unexpectedly, despite the absence of STAM1, hematopoietic cells, including T- and B-lymphocyte and other hematopoietic cell populations, developed normally and responded well to several cytokines, including IL-2 and GM-CSF. However, histological analyses revealed the disappearance of hippocampal CA3 pyramidal neurons in STAM1(-/-) mice. Furthermore, we observed that primary hippocampal neurons derived from STAM1(-/-) mice are vulnerable to cell death induced by excitotoxic amino acids or an NO donor. These data suggest that STAM1 is dispensable for cytokine-mediated signaling in lymphocytes but may be involved in the survival of hippocampal CA3 pyramidal neurons.
|
['Adaptor Proteins, Signal Transducing', 'Animals', 'Behavior, Animal', 'Brain', 'Cells, Cultured', 'Disease Susceptibility', 'Endosomal Sorting Complexes Required for Transport', 'Female', 'Fertility', 'Gene Expression', 'Gene Targeting', 'Hippocampus', 'Interleukin-2', 'Kainic Acid', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Neurons', 'Phenotype', 'Phosphoproteins', 'Seizures', 'Subcellular Fractions', 'T-Lymphocytes']
| 11,340,172
|
[['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['F01.145.113'], ['A08.186.211'], ['A11.251'], ['C23.550.291.687', 'G07.100.250'], ['D05.500.199', 'D12.776.543.990.493'], ['G08.686.210'], ['G05.297'], ['E05.393.335'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D12.776.467.374.480.372', 'D23.529.374.465.155', 'D23.529.374.480.372'], ['D03.383.773.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500.550.455', 'B01.050.150.900.649.313.992.635.505.500.800.500'], ['A08.675', 'A11.671'], ['G05.695'], ['D12.776.744'], ['C10.597.742', 'C23.888.592.742'], ['A11.284.835'], ['A11.118.637.555.567.569', 'A15.145.229.637.555.567.569', 'A15.382.490.555.567.569']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 1
| 1
| 1
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Differentiation of the elastase-type protease of platelets from other elastases.
|
Elastase activities were determined near neutral pH on several specific substrates using platelet-derived preparations mixed with decreasing amounts of leukocytes. Activities were extrapolated to zero leukocyte content enabling the estimation of intrinsic platelet elastase activity. In contrast to human leukocyte elastase, metal chelating agents inhibited partly the elastase activity of the platelet extract and soybean trypsin inhibitor did not modify its activity. Serine active site titrants (phenylmethane sulfonyl fluoride) as well as acetyl-di-L-alanyl-L-propyl-L-valine chloromethylketone completely abolished the activity of platelet lysates. The platelet protease was purified from Triton X-100 platelet lysates. No cross-reactivity could be demonstrated by immunoelectrophoresis with either porcine pancreatic elastase or human leukocyte elastase using monospecific antisera. Applying gel electrophoresis, most of the elastase activity of the platelet protease migrated towards the anode, whereas the pancreatic and leukocyte elastases migrated towards the cathode. The anionic character of the platelet enzyme might explain its capacity to degrade better elastin treated with cationic detergents in contradistinction to other elastases which act better on anionic detergent-treated elastins.
|
['Animals', 'Blood Platelets', 'Chromatography, Gel', 'Elastin', 'Humans', 'Hydrolysis', 'Immunoelectrophoresis', 'Leukocytes', 'Muscle, Smooth, Vascular', 'Pancreas', 'Pancreatic Elastase', 'Rats', 'Swine']
| 6,567,487
|
[['B01.050'], ['A11.118.188', 'A15.145.229.188'], ['E05.196.181.400.250'], ['D05.750.078.421', 'D12.776.860.300.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.380'], ['E01.370.225.812.735.645.350.350', 'E05.196.401.568', 'E05.200.812.735.645.350.350', 'E05.301.300.568', 'E05.478.594.760.645.350.350', 'E05.478.605.492.350.350'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.467.491'], ['A03.734'], ['D08.811.277.656.300.760.560', 'D08.811.277.656.959.350.560'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.500.880']]
|
['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
SARS-CoV-2 receptor is co-expressed with elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cells.
|
SARS-CoV-2, the pathogenic agent of COVID-19, employs angiotensin converting enzyme-2 (ACE2) as its cell entry receptor. Clinical data reveal that in severe COVID-19, SARS-CoV-2 infects the lung, leading to a frequently lethal triad of respiratory insufficiency, acute cardiovascular failure, and coagulopathy. Physiologically, ACE2 plays a role in the regulation of three systems that could potentially be involved in the pathogenesis of severe COVID-19: the kinin-kallikrein system, resulting in acute lung inflammatory edema; the renin-angiotensin system, promoting cardiovascular instability; and the coagulation system, leading to thromboembolism. Here we assembled a healthy human lung cell atlas meta-analysis with ~ 130,000 public single-cell transcriptomes and show that key elements of the bradykinin, angiotensin and coagulation systems are co-expressed with ACE2 in alveolar cells and associated with their differentiation dynamics, which could explain how changes in ACE2 promoted by SARS-CoV-2 cell entry result in the development of the three most severe clinical components of COVID-19.
|
['Angiotensin-Converting Enzyme 2', 'Betacoronavirus', 'Blood Coagulation', 'Gene Expression Profiling', 'Humans', 'Kallikrein-Kinin System', 'Peptidyl-Dipeptidase A', 'Pulmonary Alveoli', 'Renin-Angiotensin System', 'SARS-CoV-2', 'Serine Endopeptidases']
| 33,177,594
|
[['D08.811.277.656.350.245.042'], ['B04.820.578.500.540.150.113'], ['G09.188.390.150'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.635.500.500', 'G03.493.485', 'G03.615.500.500', 'G07.410.810.500.500', 'G09.330.380.690'], ['D08.811.277.656.350.350.687'], ['A04.411.715'], ['G03.820', 'G09.330.380.813'], ['B04.820.578.500.540.150.113.968'], ['D08.811.277.656.300.760', 'D08.811.277.656.959.350']]
|
['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]']
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 0
|
Long-term follow-up of vocal fold movement impairment and feeding after neonatal cardiac surgery.
|
OBJECTIVE: To determine the long-term prognosis of children with vocal fold mobility impairment (VFMI) after cardiac surgery, with respect to time to normal feeding and incidence of admissions for pneumonia and feeding difficulties.METHODS: A retrospective chart review was conducted of all neonates who had otolaryngology exam after cardiac surgery at a tertiary children's hospital from May 2007 to May 2008. Charts were reviewed for demographics, type of cardiac surgery, vocal fold mobility, diet at time of discharge and at last follow-up, time to full oral feeding, and hospital admissions.RESULTS: There were a total of 94 patients included in the study, 17 of whom had VFMI. While significantly more patients with VFMI required modified diet at discharge, 48% compared to 19% of patients with normal vocal fold mobility; there was no statistically significant difference in time to regular diet on long-term follow-up, 0.8 years (VFMI) compared to 0.4 years (normal vocal fold mobility). Of the 25 patients with modified diet or gastrostomy tube at discharge, 52% returned to full feeds within a year. There was no difference in hospitalizations for pneumonia in patients with or without VFMI. However in patients with VFMI, 35% required readmission for feeding difficulty or poor weight gain compared to only 5% in the infants with normal vocal fold mobility.CONCLUSION: After neonatal cardiac surgery, there do not appear to be long-term effects of VFMI with regards to readmission for pneumonia. However, there is an increased risk for hospitalization with respect to feeding difficulties in those neonates with VFMI. The overall prognosis for time to oral feeding is good.
|
['Cardiac Surgical Procedures', 'Child, Preschool', 'Feeding Methods', 'Feeding and Eating Disorders', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Male', 'Prognosis', 'Retrospective Studies', 'Vocal Cord Paralysis', 'Vocal Cords']
| 26,968,079
|
[['E04.100.376', 'E04.928.220'], ['M01.060.406.448'], ['E02.421'], ['F03.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.703'], ['M01.060.703.520'], ['E01.789'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['C08.360.931', 'C09.400.931', 'C10.292.887.800', 'C10.597.622.943', 'C23.888.592.636.943'], ['A04.329.364.737']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]']
| 1
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
The role of the clinical nurse specialist in promoting evidence-based practice and effecting positive patient outcomes.
|
Clinical nurse specialists (CNSs) are vital members of the healthcare delivery leadership team. The knowledge and expertise of the CNS is germane to the quality of care a patient receives. More than 50 CNSs practice at Massachusetts General Hospital (the state's first Magnet hospital), where they share their clinical skills, mentor staff through difficult situations, identify learning needs, and implement innovative approaches to patient care. This article presents a brief history of the CNS role and describes how the CNS role is operationalized at Massachusetts General Hospital and its impact on unit-based and organizational outcomes. In addition, several programs and interventions identified by the CNSs in response to results of the Staff Perception of the Professional Practice Environment Survey are discussed. How the CNS influences the professional development of staff and potential implications for the future role of the CNS are described. An exemplar is included depicting a typical work day of a CNS on an acute adult medical unit.
|
['Attitude of Health Personnel', 'Boston', 'Certification', 'Cooperative Behavior', 'Diffusion of Innovation', 'Education, Nursing, Continuing', 'Evidence-Based Medicine', 'Forecasting', 'Health Services Needs and Demand', 'Hospitals, General', 'Hospitals, Teaching', 'Hospitals, Urban', 'Humans', 'Interprofessional Relations', 'Job Description', 'Leadership', 'Nurse Clinicians', "Nurse's Role", 'Nursing Research', 'Nursing Staff, Hospital', 'Outcome Assessment, Health Care', 'Program Evaluation', 'Staff Development']
| 18,050,983
|
[['F01.100.050', 'N05.300.100'], ['Z01.107.567.875.550.510.210', 'Z01.433.210'], ['N03.706.110.120', 'N05.700.200.190'], ['F01.145.813.115'], ['L01.143.320'], ['I02.358.212.450', 'I02.358.462.399'], ['H02.249.750', 'H02.403.200.400'], ['I01.320'], ['N03.349.380.420', 'N05.300.450'], ['N02.278.421.389'], ['N02.278.020.300', 'N02.278.421.639'], ['N02.278.421.660'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['N04.452.677.410'], ['F01.752.609'], ['M01.526.485.650.648.525', 'N02.360.650.648.525'], ['F01.829.316.616.625.450', 'N05.300.100.337'], ['H01.770.644.145.390', 'H02.478.395', 'N04.590.233.508.613'], ['M01.526.485.680.490', 'M01.526.485.740.523', 'N02.360.680.490', 'N02.360.740.523'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['I02.574.700', 'N04.452.677.822']]
|
['Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]']
| 0
| 1
| 0
| 0
| 1
| 1
| 0
| 1
| 1
| 0
| 1
| 1
| 1
| 1
|
Influence of patellar thickness on patellar tracking and patellofemoral contact characteristics after total knee arthroplasty.
|
Although total knee arthroplasty (TKA) has become a very common procedure, patellar problems remain a major cause of disability. Patellar thickness is one of the most challenging factors. The influence of patellar thickness on patellofemoral kinematics and contact characteristics following TKA was investigated. Seven unembalmed whole-lower-extremity cadaveric specimens were used. The kinematics was measured with a magnetic tracking device (3Space Tracker System, Polhemus Navigation Sciences Division, Colchester, VT). Contact area was calculated from the kinematic data and the digitized joint surface geometrics based on a theoretical method. The patellofemoral joint contact force was measured directly using a uniaxial force transducer. Kinematically, the influence of patellar thickness on patellar flexion, rotation, and proximodistal shift was not significant. Orthopaedic surgeons are often challenged by derangement of the patellofemoral joint, especially following TKA. It is commonly assumed that restoration of overall patellar thickness is most desirable. A thin patella can reduce the contact force, but it also poses the potential risks of stress fracture and anteroposterior instability. Increasing patellar thickness might be expected to increase the effective quadriceps moment arm at low flexion angles of the knee, but potentially reduces the range of motion of the knee and predisposes to patellar subluxation. Either a thicker or a thinner patella had a smaller contact area than intact and normal-thickness patella. Therefore, the surgical technique of patellar resurfacing during TKA should attempt to reproduce the original patellar thickness.
|
['Aged', 'Biomechanical Phenomena', 'Female', 'Humans', 'In Vitro Techniques', 'Knee Joint', 'Knee Prosthesis', 'Male', 'Middle Aged', 'Patella', 'Range of Motion, Articular', 'Reference Values', 'Rotation', 'Surface Properties']
| 8,676,121
|
[['M01.060.116.100'], ['G01.154.090', 'G01.374.089'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['A02.835.583.475'], ['E07.695.400.410'], ['M01.060.116.630'], ['A02.835.232.043.650.624', 'A02.835.232.730.500'], ['E01.370.600.700', 'G11.427.760'], ['E05.978.810'], ['G01.482.703'], ['G02.860']]
|
['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]']
| 1
| 1
| 0
| 0
| 1
| 0
| 1
| 0
| 0
| 0
| 0
| 1
| 0
| 0
|
Preferences of patients' family regarding family-witnessed cardiopulmonary resuscitation: A qualitative perspective of intensive care patients' family members.
|
OBJECTIVES: To describe preferences of intensive care patients' family members regarding the idea of an inpatient family-witnessed cardiopulmonary resuscitation.RESEARCH METHODOLOGY/DESIGN: A descriptive qualitative design was used in this study. Twelve family members of intensive care patients took part in individual semi-structured interviews. Data were analysed using thematic analysis.SETTING: A population of Finnish and Polish former intensive care adult patients' relatives.FINDINGS: The thematic analysis resulted in two main themes with four subthemes each: (Theme 1) Being more involved and engaged in patient's care in case of cardiopulmonary resuscitation, with subthemes: (a) Having an option to decide, (b) Being in physical proximity to the patient, (c) Feeling like having more control and impact and (d) Having a better idea about the situation. (Theme 2) Being cared for and treated respectfully during possible cardiopulmonary resuscitation, with subthemes: (a) Need for more support and understanding from the staff, (b) Uniqueness of the family - patient relationship, (c) Need for staff to be more humane and less mechanical and (d) Professional and highly qualified staff.CONCLUSION: Results of this study suggest a possible gap in family-centred care delivery in intensive care settings. System changes are necessary in order to increase nurses' awareness of patients' families' preferences, and successfully implement recommended family-witnessed cardiopulmonary resuscitation.
|
['Adult', 'Cardiopulmonary Resuscitation', 'Family', 'Family Planning Policy', 'Female', 'Finland', 'Humans', 'Intensive Care Units', 'Male', 'Middle Aged', 'Perception', 'Poland', 'Qualitative Research']
| 29,699,912
|
[['M01.060.116'], ['E02.365.647.110'], ['F01.829.263', 'I01.880.853.150'], ['I01.655.500.608.200', 'I01.880.604.825.608.200', 'N03.623.500.608.214'], ['Z01.542.816.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493'], ['M01.060.116.630'], ['F02.463.593'], ['Z01.542.248.679'], ['H01.770.644.241.850']]
|
['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]']
| 0
| 1
| 0
| 0
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 1
| 1
| 1
|
The effect of extraction of infraoccluded deciduous molars: A longitudinal study.
|
Infraocclusion of deciduous molars is often associated with ankylosis. Such teeth are believed to be potential sites of malocclusion, with a risk of tipping of neighboring teeth and loss of space. Extraction has therefore been the most widely recommended treatment. The aim of this study was to follow longitudinally the effect of extraction versus nonextraction treatment in twenty-three homologous pairs of mandibular deciduous molars with infraocclusion when unilateral extraction was performed. The study comprised fifteen children with a mean age at the start of 10.1 years. Recordings were made at the start of the study and every 6 months thereafter until eruption of permanent successors. Periodic identical periapical radiographs and study models were taken every 6 months. Ten of the twenty-three mandibular deciduous molars on the nonextraction side showed progression of the degree of infraocclusion. All infraoccluded deciduous molars exfoliated within the normal time. There was a normal alveolar bone height on both sides after eruption of the successors. Extraction resulted in a gradually increasing space loss in fourteen of the fifteen children. In two cases a definite space deficiency at the time of eruption of the successors was registered. It has been possible to confirm very few of the previously reported negative effects following nontreatment of infraoccluded deciduous molars on exfoliation, eruption, and occlusal development in this study. The results favor a more conservative approach to extraction therapy of infraoccluded deciduous molars.
|
['Adolescent', 'Alveolar Process', 'Ankylosis', 'Child', 'Dental Arch', 'Dental Models', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Malocclusion', 'Molar', 'Tooth Diseases', 'Tooth Eruption', 'Tooth Exfoliation', 'Tooth Extraction', 'Tooth, Deciduous']
| 3,855,349
|
[['M01.060.057'], ['A02.835.232.781.324.502.125', 'A14.521.125', 'A14.549.167.646.094'], ['C05.550.069'], ['M01.060.406'], ['A02.835.232.781.324.502.320', 'A14.521.320'], ['E06.261', 'J01.897.280.500.545.129.200', 'L01.178.820.090.545.129.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['C07.793.494'], ['A14.549.167.860.525'], ['C07.793'], ['G10.549.810'], ['G10.549.820'], ['E04.545.700', 'E06.645.700'], ['A14.549.167.860.700']]
|
['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]']
| 1
| 1
| 1
| 0
| 1
| 0
| 1
| 0
| 0
| 1
| 1
| 1
| 1
| 0
|
Radiology faculty evaluation: bi-institutional implementation of an experimental appraisal instrument.
|
RATIONALE AND OBJECTIVES: The authors evaluated the reliability and validity of an experimental radiology faculty appraisal instrument.MATERIALS AND METHODS: Residents from the University of Wisconsin (UW) and Indiana University (IU) were asked to use a previously developed behaviorally based, 53-item experimental faculty appraisal instrument. Twenty UW residents evaluated 29 UW faculty members and 37 IU residents evaluated 31 IU faculty members by using the experimental instrument. Residents also evaluated faculty by using their institution's existing appraisal instrument.RESULTS: Correlations between existing and experimental forms were .69 and .87 for UW and IU, respectively. Existing form reliabilities were .89 and .94 and experimental form reliabilities were .98 and .98 for UW and IU, respectively. Experimental form length was reduced to 30 items by eliminating the questions that correlated the least with section scores. Reliabilities of scores on the shortened form were .97 and .98 and correlated .65 and .88 with scores on the longer form for UW and IU, respectively.CONCLUSION: Ratings obtained with the existing forms correlated substantially with the experimental form, attesting to the experimental form's validity. Shortening the experimental form had a minimal effect on the reliability and validity of the data obtained. The behavior-based form was used to rate behaviors that residents believed discriminated between effective and ineffective instructors, enabling an objective and relevant assessment to be made.
|
['Adult', 'Attitude of Health Personnel', 'Evaluation Studies as Topic', 'Faculty, Medical', 'Female', 'Humans', 'Indiana', 'Internship and Residency', 'Male', 'Radiology', 'Wisconsin']
| 9,809,080
|
[['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['E05.337', 'N05.715.360.335'], ['M01.526.485.375', 'M01.526.702.250.373', 'N02.360.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.360', 'Z01.107.567.875.510.360'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['H02.403.740'], ['Z01.107.567.875.350.900', 'Z01.107.567.875.510.900']]
|
['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]']
| 0
| 1
| 0
| 0
| 1
| 1
| 0
| 1
| 1
| 0
| 0
| 1
| 1
| 1
|
Candida arthritis in a premature infant treated successfully with oral fluconazole for six months.
|
INTRODUCTION: Candida arthritis in premature infants is a rare condition mainly treated with parenteral amphotericin B.CLINICAL PICTURE: Arthritis 9 weeks after birth. The infection resulted out of colonisation at birth and fungaemia at day 6 and day 13 of life.TREATMENT: Oral fluconazole for 6 months (5 mg/kg/day after loading with 7 mg/kg/day).OUTCOME: Full remission.CONCLUSIONS: Oral fluconazole is an alternative to parenteral amphotericin B in the treatment of premature infants, but proof of absorption and an extended treatment period according to prematurity might be warranted.
|
['Administration, Oral', 'Antifungal Agents', 'Arthritis, Infectious', 'Candidiasis', 'Drug Administration Schedule', 'Fluconazole', 'Follow-Up Studies', 'Humans', 'Infant', 'Infant, Newborn', 'Infant, Premature, Diseases', 'Treatment Outcome']
| 10,895,350
|
[['E02.319.267.100'], ['D27.505.954.122.136'], ['C01.100', 'C05.550.114.099'], ['C01.150.703.160'], ['E02.319.283'], ['D03.383.129.799.450'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C16.614.521'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']]
|
['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]']
| 0
| 1
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| 1
| 1
| 0
|
Use patterns among early adopters of adaptive cruise control.
|
OBJECTIVE: The objective of this study was to investigate use patterns among early adopters of adaptive cruise control (ACC).BACKGROUND: Extended use ofACC may influence a driver's behavior in the long-term, which can have unintended safety consequences.METHOD: The authors examined the use of a motion-based simulator by 24 participants (15 males and 9 females). Cluster analysis was performed on drivers' use of ACC and was based on their gap settings, speed settings, number of warnings issued, and ACC disengaged. The data were then examined on the basis of driving performance measures and drivers' subjective responses to trust in ACC, understanding of system operations, and driving styles. Driving performance measures included minimum time headway, adjusted minimum time to collision, and drivers' reaction time to critical events.RESULTS: Three groups of drivers were observed on the basis of risky behavior, moderately risky behavior, and conservative behavior. Drivers in the conservative group stayed farther behind the lead vehicle than did drivers in the other two groups. Risky drivers responded later to critical events and had more ACC warnings issued.CONCLUSION: Safety consequences with ACC may be more prevalent in some driver groups than others. The findings suggest that these safety implications are related to trust in automation, driving styles, understanding of system operations, and personalities.APPLICATION: Potential applications of this research include enhanced design for next-generation ACC systems and countermeasures to improve safe driving with ACC.
|
['Accidents, Traffic', 'Adult', 'Aged', 'Attention', 'Automation', 'Automobile Driving', 'Automobiles', 'Computer Simulation', 'Equipment Design', 'Female', 'Humans', 'Iowa', 'Male', 'Middle Aged', 'Reaction Time', 'Risk-Taking', 'Task Performance and Analysis']
| 23,156,618
|
[['N06.850.135.392'], ['M01.060.116'], ['M01.060.116.100'], ['F02.830.104.214'], ['J01.897.104'], ['I03.125'], ['J01.937.500.100'], ['L01.224.160'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.510.370'], ['M01.060.116.630'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['F01.145.722'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600']]
|
['Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]']
| 0
| 1
| 0
| 0
| 1
| 1
| 1
| 0
| 1
| 1
| 1
| 1
| 1
| 1
|
Unmet need for disability-related health care services and employment status among adults with disabilities in the Massachusetts Medicaid program.
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BACKGROUND: The employment rate among adults with disabilities is significantly lower than that among adults without disabilities. Ensuring access to rehabilitative and other health care services may help to address health-related barriers to employment for working-age people with disabilities. This study examined the relationship of unmet need for 6 disability-related health care services to current employment status among working-age adults with disabilities enrolled in the Massachusetts Medicaid (MassHealth Standard) program.METHODS: Study participants included 436 MassHealth Standard members aged 19 to 64 who responded to the 2005/2006 MassHealth Employment and Disability Survey. Variables included members' demographic characteristics; Medicaid health plan and Medicare enrollment; members' self-report of potentially disabling conditions and current health status; access to health care as well as need and unmet need for 6 specific disability-related health care services (medications, mental health services, substance abuse services, medical supplies, durable medical equipment, personal assistance services); and current employment status.RESULTS: Fifteen percent of members reported currently working. Logistic regression analysis showed that (controlling for demographics, disability, health status, and other factors) members with greater unmet need were significantly less likely to be working (odds ratio = 0.58; 95% confidence interval = 0.33 to 0.99). Members' experience of unmet need was significantly greater for physical health services (supplies, durable medical equipment, personal assistance services) than for behavioral health services (mental health and substance abuse services) or medications. Working members generally rated services as important to work. Approximately 10% to 22% of nonworking members thought they would be able to work if needs were met.CONCLUSIONS: Meeting unmet needs for disability-related health care services may result in modest increases in employment among certain working-age adults with disabilities enrolled in the Massachusetts Medicaid program.
|
['Adult', 'Attitude to Health', 'Disabled Persons', 'Employment', 'Female', 'Health Care Surveys', 'Health Services', 'Health Services Accessibility', 'Health Services Needs and Demand', 'Humans', 'Logistic Models', 'Male', 'Massachusetts', 'Medicaid', 'Middle Aged', 'Odds Ratio', 'United States', 'Young Adult']
| 22,014,668
|
[['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['M01.150'], ['N01.824.245'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['N02.421'], ['N04.590.374.350', 'N05.300.430'], ['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695.470', 'N06.850.520.830.500.525', 'N06.850.520.830.600.800.450', 'N06.850.520.830.750.450'], ['Z01.107.567.875.550.510'], ['N03.219.521.346.506.564.655', 'N03.706.615.693'], ['M01.060.116.630'], ['E05.318.740.600.600', 'G17.680.500', 'N05.715.360.750.625.590', 'N06.850.520.830.600.600'], ['Z01.107.567.875'], ['M01.060.116.815']]
|
['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]']
| 0
| 1
| 0
| 0
| 1
| 1
| 1
| 0
| 0
| 0
| 0
| 1
| 1
| 1
|
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