Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Avoidance response of Enchytraeus albidus in relation to carbendazim ageing. | In this study, avoidance response of Enchytraeus albidus to LUFA 2.2 soil contaminated with pesticide carbendazim was investigated. The aim was to clarify minimal test duration and temporal changes in avoidance response due to contamination ageing. Firstly, the concentration causing 50% avoidance (EC(50)) was determine... | ['Animals', 'Benzimidazoles', 'Carbamates', 'Dose-Response Relationship, Drug', 'Environmental Monitoring', 'Escape Reaction', 'Fungicides, Industrial', 'Oligochaeta', 'Soil Pollutants', 'Time Factors'] | 18,992,976 | [['B01.050'], ['D03.633.100.103'], ['D02.241.081.251'], ['G07.690.773.875', 'G07.690.936.500'], ['N06.850.460.350.080', 'N06.850.780.375'], ['F01.145.113.780.688', 'F01.145.367', 'F01.145.875.439.500.688', 'G07.568.500.590.688', 'G11.427.410.568.850.688'], ['D27.720.031.700.288', 'D27.888.723.288'], ['B01.050.500.091.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hypothalamic mitochondrial abnormalities occur downstream of inflammation in diet-induced obesity. | Hypothalamic dysfunction is a common feature of experimental obesity. Studies have identified at least three mechanisms involved in the development of hypothalamic neuronal defects in diet-induced obesity: i, inflammation; ii, endoplasmic reticulum stress; and iii, mitochondrial abnormalities. However, which of these m... | ['Animals', 'Biomarkers', 'Diet, High-Fat', 'Endoplasmic Reticulum Stress', 'GTP Phosphohydrolases', 'Hypothalamus', 'Inflammation', 'Mice', 'Mitochondria', 'Neutralization Tests', 'Obesity', 'Tumor Necrosis Factor-alpha'] | 28,760,600 | [['B01.050'], ['D23.101'], ['G07.203.650.240.267'], ['G04.434'], ['D08.811.277.040.330'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['C23.550.470'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['E01.370.225.812.735.550', 'E05.200.812.735.550', 'E05.478.594.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The ultrastructure of the neurons of a graft developing in the brain of rats experiencing hypoxia]. | Fragments of the brain cortex of 17- or 18-day-old rat embryos were allotransplanted into the brain cortex of rats subjected to hypoxia. Four days later the graft consisted of mixed differentiating neuroblasts. By the 100th to 130th day after transplantation the graft contained mature neurons, differentiating neurons a... | ['Acute Disease', 'Animals', 'Cell Differentiation', 'Cerebral Cortex', 'Embryo, Mammalian', 'Female', 'Hypoxia, Brain', 'Microscopy, Electron', 'Neurons', 'Rats', 'Rats, Inbred Strains', 'Time Factors'] | 2,234,792 | [['C23.550.291.125'], ['B01.050'], ['G04.152'], ['A08.186.211.200.885.287.500'], ['A16.254'], ['C10.228.140.624', 'C23.888.852.079.797'], ['E01.370.350.515.402', 'E05.595.402'], ['A08.675', 'A11.671'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chlorpromazine modulates cytokine expression in the liver and lung after burn injury and endotoxemia. | BACKGROUND: Previous data from our laboratory have demonstrated that alterations in cytokine production occur in the lung and liver as the result of a two-hit model of injury, i.e., burn with subsequent endotoxin administration. The purpose of this study was to determine whether the phenothiazine derivative chlorpromaz... | ['Animals', 'Burns', 'Chemokine CCL4', 'Chlorpromazine', 'Endotoxemia', 'Escherichia coli Infections', 'Interleukin-10', 'Liver', 'Lung', 'Macrophage Inflammatory Proteins', 'Male', 'Mice', 'Mice, Inbred Strains', 'RNA, Messenger', 'Tumor Necrosis Factor-alpha'] | 10,697,077 | [['B01.050'], ['C26.200'], ['D12.644.276.374.200.110.200', 'D12.644.276.374.200.600.200', 'D12.776.467.374.200.110.200', 'D12.776.467.374.200.600.200', 'D23.125.300.110.200', 'D23.125.300.600.750', 'D23.469.200.110.200', 'D23.529.374.200.110.200', 'D23.529.374.200.600.200'], ['D02.886.369.198', 'D03.633.300.783.198'], ... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of oestrogens and medroxyprogesterone acetate on the uptake of cytotoxic drugs by MCF-7 breast cancer cells. | Previous studies have shown that human breast cancer cells (MCF-7) show an increased response to a number of cytotoxic drugs after 48 h pretreatment with medroxyprogesterone acetate (MPA). As there is evidence that MPA can influence membrane fluidity, we have examined the effect of pre-treatment with MPA on the uptake ... | ['Antineoplastic Agents', 'Breast Neoplasms', 'Estrogens', 'Female', 'Humans', 'Medroxyprogesterone', 'Medroxyprogesterone Acetate', 'Methotrexate', 'Tumor Cells, Cultured', 'Vincristine'] | 1,533,753 | [['D27.505.954.248'], ['C04.588.180', 'C17.800.090.500'], ['D27.505.696.399.472.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.829.395.700'], ['D04.210.500.745.745.654.829.395.700.500'], ['D03.633.100.733.631.192.500'], ['A11.251.860'], ['D03.132.436.681.827.817', 'D03.633.100.473.402... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reduction of inappropriate medication in older populations by electronic decision support (the PRIMA-eDS study): a qualitative study of practical implementation in primary care. | BACKGROUND: Within the EU-funded project PRIMA-eDS (Polypharmacy in chronic diseases: Reduction of Inappropriate Medication and Adverse drug events in older populations by electronic Decision Support) an electronic decision support tool (the "PRIMA-eDS-tool") was developed for general practitioners (GPs) to reduce inap... | ['Adult', 'Aged', 'Attitude of Health Personnel', 'Decision Support Systems, Clinical', 'Female', 'General Practitioners', 'Germany', 'Humans', 'Implementation Science', 'Male', 'Middle Aged', 'Potentially Inappropriate Medication List', 'Primary Health Care', 'Qualitative Research'] | 29,986,668 | [['M01.060.116'], ['M01.060.116.100'], ['F01.100.050', 'N05.300.100'], ['L01.313.500.750.300.190'], ['M01.526.485.810.485', 'N02.360.810.485'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.143.320.400'], ['M01.060.116.630'], ['N04.761.700.615', 'N05.700.594'], ['N04.590.233.727'], ['H01.770.6... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Information Science [L]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Prognostic significance of p53 mutations in colon cancer at the population level. | Some studies have reported that p53 mutations or certain types of p53 mutation are associated with poor prognosis in colon cancer, while other studies have failed to show such a relationship. None of these previous studies was population-based. We therefore evaluated the prognostic significance of p53 mutations in a la... | ['Amino Acid Motifs', 'Codon', 'Colonic Neoplasms', 'DNA Mutational Analysis', 'Genes, p53', 'Genes, ras', 'Humans', 'Mutation', 'Polymorphism, Single-Stranded Conformational', 'Prognosis'] | 11,992,552 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['E05.393.760.700.300'], ['G05.360.340.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
One single dose of histidine-tryptophan-ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: a prospective randomized study. | OBJECTIVES: Histidine-tryptophan-ketoglutarate (HTK-Custodiol) cardioplegic solution is administered as one single dose for more than 2 hours of ischemia. No prospective randomized clinical study has compared the effects of HTK and cold blood cardioplegia on myocardial damage in elective mitral valve surgery. Thus, the... | ['Biomarkers', 'Cardiac Surgical Procedures', 'Cardioplegic Solutions', 'Chi-Square Distribution', 'Creatine Kinase, MB Form', 'Elective Surgical Procedures', 'Female', 'Glucose', 'Heart Arrest, Induced', 'Humans', 'Hypothermia, Induced', 'Linear Models', 'Male', 'Mannitol', 'Middle Aged', 'Mitral Valve', 'Mitral Valve... | 20,800,244 | [['D23.101'], ['E04.100.376', 'E04.928.220'], ['D26.776.708.160', 'D27.505.954.411.207', 'D27.505.954.578.322', 'D27.720.752.322'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['D08.811.913.696.640.150.625'], ['E04.249'], ['D09.947.875.359.448'], ['E04.100.376.374', 'E0... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Quality of life after surgery for rectal cancer. | Patients' health-related quality of life (HRQoL) is now considered a relevant clinical outcome. This study systematically reviewed articles published in the last 5 years, focusing on the impact of rectal cancer treatment on patients' HRQoL. Of the 477 articles retrieved, 56 met the inclusion criteria. The most frequent... | ['Humans', 'Laparoscopy', 'Quality of Life', 'Rectal Neoplasms', 'Rectum'] | 25,103,003 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['C04.588.274.476.411.307.790', 'C06.301.371.411.307.790', 'C06.405.249.411.307.790', 'C06.405.469.491.307.790', 'C06.405.469.860.180.500'], ['A03.556.124.526.767', 'A... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Susceptibility to cartap-induced lethal effect and diaphragmatic injury via ocular exposure in rabbits. | Cartap is extensively used to control agricultural pests. Pertinent literatures have indicated that it causes no eye irritation [D.E. Ray, Insecticides derived from plants and other organisms, in: W.J. Hayes, E.R. Laws (Eds.), Handbook of Insecticide Toxicology, Classes of Insecticides, vol. 2, Academic Press, New York... | ['Animals', 'Creatine Kinase', 'Diaphragm', 'Female', 'Heart', 'Insecticides', 'Instillation, Drug', 'L-Lactate Dehydrogenase', 'Lethal Dose 50', 'Microscopy, Electron', 'Muscle Contraction', 'Muscle, Skeletal', 'Myocardium', 'Phrenic Nerve', 'Rabbits', 'Thigh', 'Thiocarbamates'] | 14,580,782 | [['B01.050'], ['D08.811.913.696.640.150'], ['A02.633.567.900.300'], ['A07.541'], ['D27.720.031.700.491', 'D27.888.723.491'], ['E02.319.267.641'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['E05.940.402', 'G07.225.500', 'G07.690.773.875.750', 'G07.690.936.500.750'], ['E01.370.350.515.402', 'E05.595.402'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevention of rebleeding from oesophageal varices: two-year follow up of a prospective controlled trial of propranolol in addition to sclerotherapy. | A prospective randomised trial comparing propranolol and sclerotherapy to sclerotherapy alone was conducted over a 2-year follow up in a district hospital setting of unselected patients. Rebleeding and survival were analysed. Thirty-nine patients were randomised to propranolol plus sclerotherapy and 34 to sclerotherapy... | ['Adolescent', 'Adult', 'Aged', 'Blood Pressure', 'Combined Modality Therapy', 'Esophageal and Gastric Varices', 'Female', 'Follow-Up Studies', 'Humans', 'Hypertension, Portal', 'Liver Cirrhosis, Alcoholic', 'Male', 'Middle Aged', 'Propranolol', 'Prospective Studies', 'Recurrence', 'Sclerotherapy', 'Survival Analysis',... | 7,963,426 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E02.186'], ['C06.405.117.240', 'C06.552.494.414'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.494'], ['C06.552.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Central pontine myelinolysis as a complication of partial ornithine carbamoyl transferase deficiency. | Central pontine myelinolysis (CPM) is a demyelinating condition of the central pons with or without associated foci of demyelination in extrapontine areas. We present a case of partial ornithine carbamoyl transferase deficiency in a 5-year-old girl which was complicated by CPM. The patient was a previously undiagnosed ... | ['Amino Acid Metabolism, Inborn Errors', 'Ammonia', 'Child, Preschool', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Myelinolysis, Central Pontine', 'Ornithine Carbamoyltransferase Deficiency Disease'] | 7,573,173 | [['C16.320.565.100', 'C18.452.648.100'], ['D01.362.075', 'D01.625.050'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['C10.228.140.163.560', 'C10.314.500', 'C18.452.132.560'], ['C10.228.140.163.100.937.750', 'C16.320.322.828', 'C16.320.565.100.940.750', 'C16.320.565.18... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Gene Encoding a Novel Enzyme of LDH2/MDH2 Family is Lost in Plant and Animal Genomes During Transition to Land. | L-Lactate/malate dehydrogenases (LDH/MDH) and type 2 L-lactate/malate dehydrogenases (LDH2/MDH2) belong to NADH/NADPH-dependent oxidoreductases (anaerobic dehydrogenases). They form a large protein superfamily with multiple enzyme homologs found in all branches of life: from bacteria and archaea to eukaryotes, and play... | ['Animals', 'Aquatic Organisms', 'Biological Evolution', 'Databases, Genetic', 'Evolution, Molecular', 'Humans', 'L-Lactate Dehydrogenase', 'Malate Dehydrogenase', 'Oxidoreductases', 'Phylogeny', 'Plants'] | 30,607,448 | [['B01.050'], ['B05.080', 'G16.500.275.725.500.650.075'], ['G05.045', 'G16.075'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['G05.045.250', 'G16.075.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['D08.811.682.047.820.496'], ['D08.811.68... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Morphological characteristics of the intramural neural apparatus of the mesentery in neoplasms of the small and large intestines]. | The author has studied the nervous elements of the mesentery in various tumors of the large and small intestine. Different structural alterations were found in all the components of the mesentery intramural nervous apparatus: nervous cells, the intracellular plexus, nervous fibres and receptor-structures in all kinds o... | ['Adult', 'Ganglia', 'Humans', 'Intestinal Neoplasms', 'Intestine, Large', 'Intestine, Small', 'Mesentery', 'Neoplasm Staging', 'Nerve Degeneration', 'Nerve Endings', 'Neurons'] | 516,564 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Relationship between hypoxia inducible factor 1alpha: expression and neuron apoptosis during hypoxia ischemia brain damage in neonatal rats]. | OBJECTIVE: To investigate the relationship between the expression of hypoxia inducible factor la (HIF-1alpha) and the neuron apoptosis during a hypoxia ischemia brain damage and explore the role of HIF-1alpha in regulating the neuron apoptosis and repairing the brain damaged by hypoxia and ischemia.METHODS: Forty SD ra... | ['Animals', 'Apoptosis', 'Brain Injuries', 'Caspase 3', 'Cerebral Cortex', 'Disease Models, Animal', 'Female', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'Hypoxia-Ischemia, Brain', 'Immunohistochemistry', 'In Situ Nick-End Labeling', 'Male', 'Neurons', 'Random Allocation', 'Rats', 'Rats, Sprague-Dawley', 'Time Factor... | 18,277,677 | [['B01.050'], ['G04.146.954.035'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A08.186.211.200.885.287.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D1... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Identification and characterization of endoplasmic reticulum-associated degradation proteins differentially affected by endoplasmic reticulum stress. | The disposal of misfolded proteins from the lumen of the endoplasmic reticulum (ER) is one of the quality control mechanisms present in the protein secretory pathway. Through ER-associated degradation, misfolded substrates are targeted to the cytosol where they are degraded by the proteasome. We have identified four ma... | ['Amino Acid Sequence', 'Consensus Sequence', 'Endoplasmic Reticulum', 'Humans', 'Membrane Proteins', 'Molecular Sequence Data', 'Multigene Family', 'Plant Leaves', 'Plant Proteins', 'Plant Roots', 'Plant Stems', 'Ribotyping', 'Sequence Alignment', 'Sequence Homology, Amino Acid', 'Zea mays'] | 15,849,299 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.580.175'], ['A11.284.430.214.190.875.248'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543'], ['L01.453.245.667'], ['G05.360.340.024.340.645'], ['A18.024.812'], ['D12.776.765'], ['A18.400'], ['A18.024.937'], ['E01.370.225.875.150.125.765', 'E05.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Thermodynamics of double- and triple-helical aggregates formed by self-complementary oligoribonucleotides of the type rAxUy. | The thermal denaturation of a series of oligoribonucleotides of the form rAxUy (x = 5 or 7 and y = 3-11) has been characterized by means of IR spectroscopy, UV spectroscopy, and DSC. IR spectra proved the occurrence of double- and triple-helical regions at various contents of uracil residues in the nucleotide. From DSC... | ['Codon', 'Models, Chemical', 'Nucleic Acid Conformation', 'Oligoribonucleotides', 'RNA, Double-Stranded', 'Spectrophotometry, Infrared', 'Thermodynamics'] | 2,383,543 | [['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['E05.599.495'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.695.578.424.500'], ['D13.444.735.490', 'G02.111.570.820.486.775', 'G05.360.580.775'], ['E05.196.712.726.676', 'E05.196.867.826.676'], ['G01.906']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Psychometric testing of an instrument measuring nurse aides' patient safety attitudes. | AIM: To develop and test the patient safety attitude scale-nurse aide (PSAS-NA) scale in measuring nurse aides' attitudes to patient safety and event reporting.BACKGROUND: Although nurse aides are unlicensed personnel, their roles in delivering care can not be ignored. A measure specific to nurse aides is needed.METHOD... | ['Adult', 'Attitude of Health Personnel', 'Cross-Sectional Studies', 'Factor Analysis, Statistical', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nursing Assistants', 'Patient Safety', 'Principal Component Analysis', 'Psychometrics', 'Reproducibility of Results'] | 23,410,086 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.740.400', 'N05.715.360.750.350', 'N06.850.520.830.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.526.485.067.652', 'N02.360.067.652'], ['N06.850.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Structure of the N-terminal Gyrase B fragment in complex with ADP?Pi reveals rigid-body motion induced by ATP hydrolysis. | Type II DNA topoisomerases are essential enzymes that catalyze topological rearrangement of double-stranded DNA using the free energy generated by ATP hydrolysis. Bacterial DNA gyrase is a prototype of this family and is composed of two subunits (GyrA, GyrB) that form a GyrA2GyrB2 heterotetramer. The N-terminal 43-kDa ... | ['Adenosine Diphosphate', 'Adenosine Triphosphatases', 'Adenosine Triphosphate', 'Binding Sites', 'DNA Gyrase', 'DNA, Superhelical', 'Escherichia coli', 'Escherichia coli Proteins', 'Hydrolysis', 'Motion', 'Protein Structure, Tertiary'] | 25,202,966 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D08.811.277.040.025'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G02.111.570.120'], ['D08.811.399.403.741.149', 'D12.776.097.237'], ['D13.444.308.283.250', 'G02.111.570.820.486.212.250', 'G05.360.580... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dendritic cells stimulated with Actinobacillus actinomycetemcomitans elicit rapid gamma interferon responses by natural killer cells. | Human immunoglobulin G2 (IgG2) responses are gamma interferon (IFN-gamma) dependent, and monocyte-derived dendritic cells (mDCs) promote IgG2 production. DCs spontaneously emerge from monocytes in cultures prepared from localized aggressive periodontitis (LagP) patients, and these patients have high levels of IgG2 that... | ['Aggregatibacter actinomycetemcomitans', 'Dendritic Cells', 'Humans', 'Interferon-gamma', 'Interleukin-12', 'Killer Cells, Natural', 'Lipopolysaccharides', 'Membrane Glycoproteins', 'Monocytes', 'Protein Subunits', 'Receptors, Cell Surface', 'Toll-Like Receptor 4', 'Toll-Like Receptors'] | 15,322,002 | [['B03.440.450.600.224.500', 'B03.660.250.550.170.500'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893', 'D23... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intraoral malignant melanotic schwannoma. Ultrastructural evidence for melanogenesis by Schwann's cells. | Clinical and light and electron microscopic findings of one case of malignant melanotic schwannoma of the oral cavity are presented. The tumor recurred four times and developed submandibular metastasis. At autopsy, 24 months after manifestation of the initial symptoms, a hematogenous metastatic nodule was present in th... | ['Female', 'Humans', 'Lymphatic Metastasis', 'Melanocytes', 'Melanoma', 'Middle Aged', 'Neurilemmoma', 'Palatal Neoplasms'] | 6,687,793 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['A11.409.750', 'A11.436.613'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['M01.060.116.630'], ['C04.557.465.625.650.595', 'C04.557.580.600.610.595', 'C04.557.580.625.650.595'], ['C04.588.149.7... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Perfluoroalkyl substances and metabolic syndrome. | BACKGROUND: Perfluoroalkyl substances (PFAS) are a class of contaminants used in many industrial applications and consumer products. Certain PFAS are regulated or voluntarily limited due to concern about environmental persistence and adverse health effects.OBJECTIVES: In this analysis we examine PFAS levels and their a... | ['Adult', 'Environmental Exposure', 'Female', 'Fluorocarbons', 'Humans', 'Male', 'Metabolic Syndrome', 'Middle Aged', 'Nutrition Surveys'] | 30,290,996 | [['M01.060.116'], ['N06.850.460.350'], ['D02.455.526.510.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968.500.570', 'C18.452.625'], ['M01.060.116.630'], ['E05.318.308.980.485', 'N05.715.360.300.800.469', 'N06.850.505.616', 'N06.850.520.308.980.469']] | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data. | The independent and joint associations of serum selenium and vitamin A (retinol) and E (alpha tocopherol) concentrations with the risk of death from cancer were studied in 51 case-control pairs--that is, 51 patients with cancer, each paired with a control matched for age, sex, and smoking. Case-control pairs came from ... | ['Adult', 'Cholesterol', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Prospective Studies', 'Risk', 'Selenium', 'Smoking', 'Vitamin A', 'Vitamin A Deficiency', 'Vitamin E', 'Vitamin E Deficiency'] | 3,918,611 | [['M01.060.116'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Low income, race, and the use of mammography. | OBJECTIVE: To describe national trends in mammography use by race and income and to test whether higher use of mammography among low-income African American women than low-income white women can be explained by health insurance coverage, usual place of health care, or place of residence.DATA SOURCES/STUDY SETTING: Data... | ['African Americans', 'European Continental Ancestry Group', 'Female', 'Humans', 'Income', 'Insurance Coverage', 'Logistic Models', 'Mammography', 'Middle Aged', 'National Center for Health Statistics, U.S.', 'Odds Ratio', 'Patient Acceptance of Health Care', 'Poverty', 'United States'] | 10,199,671 | [['M01.686.508.100.100', 'M01.686.754.100'], ['M01.686.508.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['N03.219.521.576.265'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360... | ['Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effects of acute rejection and antirejection therapy on arteries and veins from canine single lung allografts. | Experiments were designed to compare the function of the endothelium and smooth muscle in intralobar pulmonary arteries and veins of transplanted lungs during acute rejection and after treatment of rejection. Single lung allografts were performed in dogs. Dogs were monitored for 5 days to allow good recovery from the o... | ['Animals', 'Azathioprine', 'Cyclosporine', 'Dogs', 'Drug Therapy, Combination', 'Endothelium, Vascular', 'Female', 'Graft Rejection', 'Immunosuppressive Agents', 'Lung Transplantation', 'Male', 'Methylprednisolone', 'Muscle, Smooth, Vascular', 'Pulmonary Artery', 'Pulmonary Veins', 'Reference Values', 'Transplantation... | 8,642,824 | [['B01.050'], ['D02.886.759.111', 'D03.633.100.759.570.090', 'D13.570.900.111'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['B01.050.150.900.649.313.750.250.216.200'], ['E02.319.310'], ['A07.015.700.500', 'A10.272.491.355'], ['G12.875.545.328'], ['D27.505.696.477.656'], ['E04.928.600.495', 'E04.936.450.495'], ['D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytotoxicity of formaldehyde on human osteoblastic cells is related to intracellular glutathione levels. | Formaldehyde that leaches out of formaldehyde-releasing root canal sealers, specifically from setting material extruded into the periapical region may participate in the development of periapical inflammation or the continuation of a pre-existing periapical lesion. However, the effects of formaldehyde on human osteobla... | ['Buthionine Sulfoximine', 'Cell Line', 'Cell Proliferation', 'Formaldehyde', 'Glutathione', 'Humans', 'Osteoblasts', 'Pyrrolidonecarboxylic Acid', 'Root Canal Filling Materials', 'Thiazolidines'] | 17,385,229 | [['D02.886.030.676.620.125', 'D12.125.166.676.620.125'], ['A11.251.210'], ['G04.161.750', 'G07.345.249.410.750'], ['D02.047.407'], ['D12.644.456.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.629'], ['D03.383.773.812.718', 'D12.125.067.625.850', 'D12.125.072.401.761'], ['D25.339.859', 'J01.637.051.33... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity in patients with panic disorder. | BACKGROUND: The catechol-O-methyltransferase (COMT) gene val158met polymorphism (rs4680) has been found to be associated with various psychiatric phenotypes including panic disorder. Considering the probable genetic influence of COMT on the pathogenesis of panic disorder and white matter connectivity, the present study... | ['Adult', 'Brain', 'Catechol O-Methyltransferase', 'Diffusion Tensor Imaging', 'Female', 'Genotype', 'Humans', 'Male', 'Middle Aged', 'Panic Disorder', 'Polymorphism, Genetic', 'Young Adult'] | 23,141,115 | [['M01.060.116'], ['A08.186.211'], ['D08.811.913.555.500.250'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F03.080.700'], ['G05.365.795'], ['M01.060.116.815']] | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Reaction mechanism of recombinant 3-oxoacyl-(acyl-carrier-protein) synthase III from Cuphea wrightii embryo, a fatty acid synthase type II condensing enzyme. | A unique feature of fatty acid synthase (FAS) type II of higher plants and bacteria is 3-oxoacyl-[acyl-carrier-protein (ACP)] synthase III (KAS III), which catalyses the committing condensing reaction. Working with KAS IIIs from Cuphea seeds we obtained kinetic evidence that KAS III catalysis follows a Ping-Pong mechan... | ['3-Oxoacyl-(Acyl-Carrier-Protein) Synthase', 'Base Sequence', 'Catalytic Domain', 'Circular Dichroism', 'Cloning, Molecular', 'DNA Primers', 'Escherichia coli', 'Fatty Acid Synthases', 'Kinetics', 'Magnoliopsida', 'Mutagenesis, Site-Directed', 'Recombinant Proteins', 'Seeds', 'Substrate Specificity'] | 10,600,651 | [['D08.811.913.050.622'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['E05.196.867.151'], ['E05.393.220'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D08.811.277.352.897... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
[Reasons for underuse of oral anticoagulation in atrial fibrillation-associated stroke: prospective study of German stroke patients]. | Oral anticoagulation in atrial fibrillation (AF) is effective in primary and secondary prevention of cardioembolic stroke, but is often underused in practice. The detailed reasons for non-use of oral anticoagulation are less well known. We prospectively analyzed 105 consecutive cases of acute ischemic stroke associated... | ['Administration, Oral', 'Aged', 'Anticoagulants', 'Atrial Fibrillation', 'Brain Ischemia', 'Drug Utilization', 'Electrocardiography', 'Female', 'Germany', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Risk Factors', 'Stroke'] | 18,604,772 | [['E02.319.267.100'], ['M01.060.116.100'], ['D27.505.954.502.119'], ['C14.280.067.198', 'C23.550.073.198'], ['C10.228.140.300.150', 'C14.907.253.092'], ['N04.452.706.477'], ['E01.370.370.380.240', 'E01.370.405.240'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.50... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Screening programs to identify children at risk for diabetes mellitus: psychological impact on children and parents. | Screening programs to identify persons atrisk for diabetes mellitus (DM), before disease onset, are considered essential to understanding the natural history of the disease and for prevention program development. However, screening programs are complicated by imprecise markers of disease risk, the absence of a known ef... | ['Anxiety', 'Child, Preschool', 'Diabetes Mellitus, Type 1', 'Humans', 'Mass Screening', 'Parents', 'Risk Factors'] | 11,393,559 | [['F01.470.132'], ['M01.060.406.448'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['F01.829.263.500.320', 'I01.... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Talker- and language-specific effects on speech intelligibility in noise assessed with bilingual talkers: Which language is more robust against noise and reverberation? | OBJECTIVE: Investigate talker- and language-specific aspects of speech intelligibility in noise and reverberation using highly comparable matrix sentence tests across languages.DESIGN: Matrix sentences spoken by German/Russian and German/Spanish bilingual talkers were recorded. These sentences were used to measure spee... | ['Acoustic Stimulation', 'Acoustics', 'Adult', 'Auditory Threshold', 'Comprehension', 'Female', 'Humans', 'Male', 'Multilingualism', 'Noise', 'Observer Variation', 'Perceptual Masking', 'Predictive Value of Tests', 'Recognition, Psychology', 'Reproducibility of Results', 'Sound Spectrography', 'Speech Acoustics', 'Spee... | 26,486,466 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['H01.671.031'], ['M01.060.116'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['F02.463.188.357'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.559.423.452'], ['G01.750.770.776.567', 'G16.500.275.600', 'N06.230.400', 'N06.850.460.610'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Conditioned fear exacerbates acute morphine dependence. | A variety of physical stressors have been shown to enhance reactivity to opioid drugs. Few studies have examined the effects of nonphysical stressors on opioid drug reactivity. In this regard, it has previously been shown that animals administered morphine in the presence of shock-associated cues demonstrate increases ... | ['Animals', 'Conditioning, Psychological', 'Electroshock', 'Fear', 'Male', 'Morphine Dependence', 'Naloxone', 'Pain Measurement', 'Rats', 'Rats, Sprague-Dawley', 'Substance Withdrawal Syndrome'] | 7,667,361 | [['B01.050'], ['F02.463.425.179'], ['E05.723.402.403', 'F04.669.224'], ['F01.470.361'], ['C25.775.643.500.600', 'F03.900.647.500.600'], ['D03.132.577.249.706', 'D03.605.497.750', 'D03.633.400.686.750', 'D04.615.723.795.706'], ['E01.370.600.550.324'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.31... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Making health care more sustainable: the case of the English NHS. | The NHS is the most revered organisation in Britain: 'the proudest achievement of our modern society'. It is certainly the largest, although since its inception in 1948 it has operated in a government-funded environment of restricted resources. Nevertheless, it has also benefitted from a generally effective model of in... | ['Delivery of Health Care', 'Humans', 'State Medicine', 'United Kingdom'] | 26,410,181 | [['N04.590.374', 'N05.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.349.550.902', 'N03.858'], ['Z01.542.363']] | ['Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The 5-D itch scale: a new measure of pruritus. | BACKGROUND: Itching is a subjective and multidimensional experience which is difficult to quantify. Most methodologies to assess itching suffer from being unidimensional, for example only measuring intensity without impact on quality of life, or only measuring scratching activity. None has actually been demonstrated to... | ['Adult', 'Chronic Disease', 'Disability Evaluation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pruritus', 'Quality of Life', 'Severity of Illness Index', 'Statistics as Topic', 'Surveys and Questionnaires'] | 19,995,367 | [['M01.060.116'], ['C23.550.291.500'], ['E01.370.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C17.800.685', 'C23.888.885.625'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
3D Shape-Based Body Composition Inference Model Using a Bayesian Network. | Body composition can be assessed in many different ways. High-end medical equipment, such as Dual-energy X-ray Absorptiometry (DXA), Computed Tomography (CT), and Magnetic Resonance Imaging (MRI) offers high-fidelity pixel/voxel-level assessment, but is prohibitive in cost. In the case of DXA and CT, the approach expos... | ['Algorithms', 'Bayes Theorem', 'Body Composition', 'Data Mining', 'Female', 'Humans', 'Imaging, Three-Dimensional', 'Supervised Machine Learning', 'Whole Body Imaging'] | 30,843,854 | [['G17.035', 'L01.224.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['L01.313.500.750.280.199', 'L01.470.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['G17.035.250.500.500', 'L01.224.050... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK. | Cumulative exposure to solar ultraviolet (SUV) irradiation is regarded as the major etiologic factor in the development of skin cancer. The activation of the MAPK cascades occurs rapidly and is vital in the regulation of SUV-induced cellular responses. The T-LAK cell-originated protein kinase (TOPK), an upstream activa... | ['Animals', 'Antineoplastic Agents', 'Cell Line, Tumor', 'Cell Proliferation', 'Cell Transformation, Neoplastic', 'Disease Models, Animal', 'Enzyme Activation', 'Female', 'Gene Expression', 'Genes, Reporter', 'Humans', 'Mice', 'Mitogen-Activated Protein Kinase Kinases', 'Protein Kinase Inhibitors', 'Signal Transduction... | 28,655,782 | [['B01.050'], ['D27.505.954.248'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G02.111.263', 'G03.328'], ['G05.297'], ['G05.360.340.024.340.435'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Prostaglandin E1 decreases the low-density-lipoprotein entry into rabbit arterial wall. | 1. In 72 male rabbits fed a 1% cholesterol supplemented diet the effect of a 4 weeks daily infusion of prostaglandin E1 (PGE1, 20 micrograms kg-1 min-1 over 2 h) on [125I]-low density lipoprotein (LDL) accumulation (10 microCi; 0.5 mg protein ml-1) was examined versus sham-treatment after removal of the endothelium of ... | ['Alprostadil', 'Animals', 'Aorta, Abdominal', 'Arteries', 'Cholesterol, Dietary', 'Endothelium, Vascular', 'In Vitro Techniques', 'Iodine Radioisotopes', 'Lipoproteins, LDL', 'Male', 'Rabbits'] | 1,933,127 | [['D10.251.355.255.550.250.100', 'D10.251.355.325.050', 'D23.469.050.175.725.250.100'], ['B01.050'], ['A07.015.114.056.205'], ['A07.015.114'], ['D04.210.500.247.808.197.225', 'D10.212.302.347', 'D10.570.938.208.222'], ['A07.015.700.500', 'A10.272.491.355'], ['E05.481'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Serological and biomolecular survey on canine herpesvirus-1 infection in a dog breeding kennel. | Canine herpesvirus-1 (CaHV-1) is a globally distributed pathogen causing reproductive, respiratory, ocular and neurological disorders in adult dogs and neonatal death in puppies. This pathogen is considered poorly immunogenic, and neutralizing antibodies are found for only a short time following exposure. Further, sero... | ['Animals', 'Dog Diseases', 'Dogs', 'Female', 'Herpesviridae Infections', 'Herpesvirus 1, Canid', 'Italy', 'Male', 'Polymerase Chain Reaction', 'Prevalence', 'Risk Factors', 'Serologic Tests'] | 26,726,105 | [['B01.050'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['C01.925.256.466'], ['B04.280.382.100.900.420'], ['Z01.542.489'], ['E05.393.620.500'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['E05.318.740.600.800.725', 'N05.715.350.200.7... | ['Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The inhibitor of F VIIa in plasma measured with a sensitive chromogenic substrate assay: comparison with antithrombin, protein C and heparin cofactor II in a clinical material. | The plasma inhibitor(s) of factor VIIa-tissue thromboplastin cooperates with factor Xa. This "Extrinsic Pathway Inhibitor" has been quantitated with a sensitive chromogenic substrate assay. Gel filtration of plasma separates 3 EPI peaks. Postoperatively, both EPI and the other coagulation inhibitors decrease. Unlike th... | ['Antithrombins', 'Biomarkers', 'Chromatography, Gel', 'Disseminated Intravascular Coagulation', 'Factor VII', 'Factor VIIa', 'Glycoproteins', 'Heparin Cofactor II', 'Humans', 'Pneumonia', 'Protein C'] | 2,465,215 | [['D27.505.519.389.745.800.449', 'D27.505.954.502.119.500'], ['D23.101'], ['E05.196.181.400.250'], ['C15.378.100.220', 'C15.378.463.250', 'C15.378.925.220'], ['D08.622.432', 'D12.776.124.125.325', 'D12.776.811.243.432', 'D23.119.325'], ['D08.811.277.656.300.760.300', 'D08.811.277.656.959.350.300', 'D12.776.124.125.325.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cerebrofaciothoracic syndrome. | We report on a patient with a large septum pellucidum, hypodensity of gray matter, hypertelorism, and costovertebral anomalies. Only 5 previous cases have been described with this distinctive phenotype. Autosomal recessive inheritance seems likely. | ['Abnormalities, Multiple', 'Brain', 'Humans', 'Hypertelorism', 'Infant, Newborn', 'Male', 'Phenotype', 'Syndrome', 'Thoracic Vertebrae'] | 8,669,442 | [['C16.131.077'], ['A08.186.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.099.370.231.480', 'C05.660.207.231.480', 'C16.131.621.207.231.480'], ['M01.060.703.520'], ['G05.695'], ['C23.550.288.500'], ['A02.835.232.834.892']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Type II papillary histology predicts poor outcome in patients with renal cell carcinoma and vena cava thrombus. | UNLABELLED: What's known on the subject? and What does the study add? In patients with pRCC, the presence of venous tumour thrombus is known to be a predictor of poorer outcomes. However, a paucity of data is available regarding the prognostic significance of histology in patients with RCC and IVC thrombus. In our seri... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Renal Cell', 'Female', 'Follow-Up Studies', 'Humans', 'Kidney Neoplasms', 'Male', 'Middle Aged', 'Prognosis', 'Proportional Hazards Models', 'Republic of Korea', 'Retrospective Studies', 'Survival Rate', 'Thrombectomy', 'Vena Cava, Inferior', 'Venous Thrombosis'] | 22,973,869 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. | Genetically obese fatty/fatty rats and obese/obese mice exhibit increased sensitivity to endotoxin hepatotoxicity, quickly developing steatohepatitis after exposure to low doses of lipopolysaccharide (LPS). Among obese animals, females are more sensitive to endotoxin liver injury than males. LPS induction of tumor necr... | ['Animals', 'Escherichia coli', 'Fatty Liver', 'Female', 'Hepatitis, Animal', 'Kupffer Cells', 'Lipopolysaccharides', 'Liver', 'Male', 'Mice', 'Mice, Obese', 'Obesity', 'Polymerase Chain Reaction', 'Rats', 'Rats, Zucker', 'Sex Characteristics', 'Time Factors', 'Tumor Necrosis Factor-alpha'] | 9,122,234 | [['B01.050'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C06.552.241'], ['C01.436', 'C06.552.380.315', 'C22.467'], ['A11.329.372.588', 'A11.627.482.588', 'A11.733.397.588', 'A15.382.670.522.588', 'A15.382.680.397.588'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Camperdown Program for adults who stutter: a student training clinic Phase I trial. | OBJECTIVES: During speech pathology professional preparation there is a need for adequate student instruction with speech-restructuring treatments for adults. An important part of that clinical educational experience is to participate in a clinical setting that produces outcomes equivalent to those attained during clin... | ['Adult', 'Ambulatory Care Facilities', 'Female', 'Humans', 'Male', 'Middle Aged', 'Observer Variation', 'Patient Satisfaction', 'Program Evaluation', 'Speech', 'Speech Production Measurement', 'Speech Therapy', 'Stuttering', 'Treatment Outcome', 'Young Adult'] | 22,788,223 | [['M01.060.116'], ['N02.278.035'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', 'N05.300.150.800.625', 'N05.715.360.600'], ['E05.337.820', 'N04.761... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Relationship with health care provider and adherence to HIV medications. | Suboptimal adherence to antiretroviral medications was reported in a sample of 97 inner-city residents with HIV/AIDS. Most respondents had been seeing the same physician for several years. Those who perceived themselves to be more engaged with their health care provider also reported better treatment adherence. This fi... | ['Antiviral Agents', 'HIV Seropositivity', 'Health Personnel', 'Humans', 'Patient Compliance', 'Physician-Patient Relations'] | 14,650,680 | [['D27.505.954.122.388'], ['C01.221.250.875.500', 'C01.221.812.640.400.500', 'C01.778.640.400.500', 'C01.925.782.815.616.400.500', 'C01.925.813.400.500', 'C20.673.480.500'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500.600', 'F01.145.488.887.500.600', 'N05.300.150.8... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
On-line coupling of solid-phase extraction with mass spectrometry for the analysis of biological samples. II. Determination of clenbuterol in urine using multiple-stage mass spectrometry in an ion-trap mass spectrometer. | Solid-phase extraction (SPE) was coupled to ion-trap mass spectrometry to determine clenbuterol in urine. For SPE a cartridge exchanger was used and, after extraction, the eluate was directly introduced into the mass spectrometer. For two types of cartridges, i.e. C18 and polydivinylbenzene (PDVB), the total SPE proced... | ['Amino Acid Sequence', 'Aspartic Acid', 'Hydrolysis', 'Molecular Sequence Data', 'Peptides', 'Spectrometry, Mass, Electrospray Ionization', 'Trypsin'] | 11,114,016 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.125.067.500', 'D12.125.119.170', 'D12.125.427.040'], ['G02.380'], ['L01.453.245.667'], ['D12.644'], ['E05.196.566.600'], ['D08.811.277.656.300.760.895', 'D08.811.277.656.959.350.895']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Molecular survey on the presence of zoonotic arthropod-borne pathogens in wild red deer (Cervus elaphus). | To estimate the prevalence of some zoonotic tick-borne pathogens in red deer (Cervus elaphus) living in Italian areas with high risk of arthropod exposure, blood samples from 60 red deer were tested by PCR for A. phagocytophilum, Borrelia burgdorferi s.l., Coxiella burnetii, Francisella tularensis, and piroplasms. Thir... | ['Anaplasma phagocytophilum', 'Animals', 'Animals, Wild', 'Babesia', 'Borrelia burgdorferi', 'Coxiella burnetii', 'Deer', 'Disease Reservoirs', 'Ehrlichiosis', 'Francisella tularensis', 'Italy', 'Ixodes', 'Polymerase Chain Reaction', 'Tick-Borne Diseases', 'Zoonoses'] | 27,477,510 | [['B03.440.664.750.050.600', 'B03.660.050.783.500.050.600'], ['B01.050'], ['B01.050.050.300'], ['B01.043.075.600.580.070'], ['B03.440.425.410.711.193.150.125', 'B03.851.595.193.150.125'], ['B03.440.400.425.297.150.100', 'B03.660.250.132.150.100'], ['B01.050.150.900.649.313.500.380.373'], ['N06.850.520.203.250'], ['C01.... | ['Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The use of potato fibre to improve bread physico-chemical properties during storage. | Bread staling reduction is a very important issue for the food industry. A fibre with high water holding capacity, extracted from potato peel, was studied for its ability to reduce bread staling even if employed at low level (0.4 g fibre/100 g flour). Physico-chemical properties (water activity, moisture content, froze... | ['Bread', 'Dietary Fiber', 'Food Storage', 'Magnetic Resonance Spectroscopy', 'Solanum tuberosum', 'Water'] | 26,575,713 | [['G07.203.300.100', 'J02.500.100'], ['D09.301.416', 'G07.203.300.400', 'J02.500.400'], ['J01.576.423.200.387'], ['E05.196.867.519'], ['B01.650.940.800.575.912.250.908.500.725.777'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate exhibits antihypertensive activity in rats through increase in intracellular cGMP level and blockade of calcium channels. | We report here the antihypertensive and vasorelaxant potential of some steroidal and non-steroidal compounds identified through a library of compounds. All the novel analogues showed vasorelaxant potential in isolated rat aorta. The most potent lead neolignan1 (Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate... | ['Animals', 'Antihypertensive Agents', 'Aorta', 'Calcium Channel Blockers', 'Calcium Channels', 'Coumaric Acids', 'Cyclic GMP', 'Intracellular Space', 'Lignans', 'Male', 'Molecular Docking Simulation', 'Potassium Channels', 'Protein Conformation', 'Rats', 'Rats, Inbred SHR', 'Vasodilation'] | 28,159,537 | [['B01.050'], ['D27.505.954.411.162'], ['A07.015.114.056'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['D02.241.223.200.210'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.69... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Activity of alkaline and acid phosphatases in dental epithelial cells and enameloid during odontogenesis in two teleost fish, Oreochromis niloticus and Tilapia buttikoferi. | The dental epithelial cells and enameloid at the stages of enameloid matrix formation, mineralization and maturation in the teleosts Oreochromis niloticus and Tilapia buttikoferi were investigated by means of enzyme histochemistry in order to identify their functions associated with the structural modification. No mark... | ['Acid Phosphatase', 'Alkaline Phosphatase', 'Animals', 'Dental Enamel', 'Epithelial Cells', 'Microscopy, Electron', 'Odontogenesis', 'Tilapia'] | 9,541,265 | [['D08.811.277.352.650.025'], ['D08.811.277.352.650.035'], ['B01.050'], ['A14.549.167.900.255'], ['A11.436'], ['E01.370.350.515.402', 'E05.595.402'], ['G07.345.500.325.377.750'], ['B01.050.150.900.493.602.200.800']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oocyte maturation in the mummichog (Fundulus heteroclitus): effects of steroids on germinal vesicle breakdown of intact follicles in vitro. | The effects of several steroids on the maturation of follicle-enclosed oocytes of the mummichog Fundulus heteroclitus in vitro were examined. At a relatively high concentration (1.0 microgram/ml), a number of different steroids, including pregnenolone, 17 alpha-hydroxypregnenolone, corticosterone, cortisol, 11-deoxycor... | ['20-alpha-Dihydroprogesterone', 'Animals', 'Cyprinodontiformes', 'Female', 'Hydroxyprogesterones', 'In Vitro Techniques', 'Killifishes', 'Oocytes', 'Oogenesis', 'Ovarian Follicle', 'Steroids'] | 3,781,226 | [['D04.210.500.745.745.654.829.100', 'D06.472.334.851.687.750.074'], ['B01.050'], ['B01.050.150.900.493.850.280'], ['D04.210.500.745.745.654.829.395', 'D06.472.334.851.687.750.478'], ['E05.481'], ['B01.050.150.900.493.850.280.500'], ['A05.360.490.690.680', 'A11.497.497.600'], ['G04.152.650.249', 'G08.686.784.310.500'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Proposal for a unified selection to medical residency programs. | OBJECTIVE: This paper proposes the unification of entrance exams to medical residency programs (MRP) in Brazil. Problems related to MRP and its interface with public health problems in Brazil are highlighted and how this proposal are able to help solving these problems.METHODS: The proposal is to create a database to b... | ['Brazil', 'Clinical Competence', 'Curriculum', 'Education, Medical, Undergraduate', 'Educational Measurement', 'Humans', 'Internship and Residency', 'Models, Educational', 'Quality Assurance, Health Care', 'Teaching'] | 24,215,667 | [['Z01.107.757.176'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.158'], ['I02.358.399.450'], ['I02.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['E05.599.545', 'I02.903.302'], ['N04.761.700', 'N05.700'], ['I02.903']] | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Correlates of fatigue phenomenon in palliative care patients with advance cancers in Taiwan. | BACKGROUND: Fatigue is a multidimensional phenomenon that has different meanings according to different societal and cultural settings. This study aims to decipher fatigue in Taiwanese patients with cancer.METHODS: We recruited 440 patients with advanced cancer admitted consecutively to the palliative care unit of a ma... | ['Adult', 'Aged', 'Aged, 80 and over', 'Fatigue', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Neoplasms', 'Palliative Care', 'Prospective Studies', 'Severity of Illness Index', 'Taiwan'] | 22,612,408 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['M01.060.116.630'], ['C04'], ['E02.760.666', 'N02.421.585.666'], ['E05.318.372.500.750.625', 'N05.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Dilemmas surrounding passive euthanasia--a Malaysian perspective. | In western societies where the principle of autonomy is jealously guarded, perhaps active euthanasia is more often the focus of public concern and debates rather than any other forms of euthanasia. However due to the advance in technology and its corresponding ability in prolonging life, in Malaysia passive euthanasia ... | ['Euthanasia, Passive', 'Humans', 'Malaysia'] | 16,229,394 | [['E02.760.905.199.500', 'E02.760.952.500', 'N02.421.585.905.199.625', 'N02.421.585.952.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.145.487']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Isolation and characterization of the complete mitochondrial genome of Taenioides anguillaris (Gobiidae: Amblyopinae) with phylogenetic consideration. | Here we first isolated and characterized the complete mitochondrial genome DNA of Taenioides anguillaris. It was 16 974 bp in length, and contained 13 protein-coding genes, 22 tRNA genes, two rRNA genes, and a putative control region. The structure and the gene arrangement of this genome were identical to those isolate... | ['Animals', 'Base Composition', 'Evolution, Molecular', 'Genes, Mitochondrial', 'Genome, Mitochondrial', 'Perciformes', 'Phylogeny', 'Sequence Analysis, DNA'] | 26,642,858 | [['B01.050'], ['G02.111.080'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.024.340.365', 'G05.420.275.500'], ['G05.360.340.360'], ['B01.050.150.900.493.602'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.760.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles. | Binge alcohol consumption is a health problem, but differences between the sexes remain poorly defined. We have examined the in vivo effects of three acute, repeat binge alcohol administration on the liver in male and female rats. Sprague-Dawley rats were gavaged with alcohol (5 g/kg body weight) three times at 12-hour... | ['Animals', 'Binge Drinking', 'Cytochrome P-450 CYP2E1', 'Diacylglycerol Kinase', 'Epigenesis, Genetic', 'Ethanol', 'Female', 'Glycerophospholipids', 'Liver', 'MAP Kinase Signaling System', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Sex Factors', 'Transcription, Genetic'] | 31,262,967 | [['B01.050'], ['C25.775.100.437', 'F01.145.317.269.500', 'F03.900.100.550'], ['D08.244.453.491.375', 'D08.811.682.662.582.338', 'D08.811.682.690.708.170.450.375', 'D12.776.422.220.453.491.375'], ['D08.811.913.696.620.200'], ['G05.308.203'], ['D02.033.375'], ['D10.570.755.375.760.400'], ['A03.620'], ['G02.111.820.560', ... | ['Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Association of cancer of the thyroid gland with other malignant tumors]. | In a group of 705 cases of thyroid cancer, 30 female patients (4.2%) had malignant tumors of other sites. Primary multiple neoplasms were registered in 5.8% of female cases. Combinations of thyroid cancer with breast or reproductive organs tumors were observed most frequently: 46.6 and 30%, respectively. In 10%, a seco... | ['Adolescent', 'Adult', 'Aged', 'Breast Neoplasms', 'Carcinoma, Papillary', 'Carcinoma, Squamous Cell', 'Female', 'Humans', 'Lymphatic Metastasis', 'Lymphoma', 'Male', 'Mastectomy', 'Middle Aged', 'Neoplasm Metastasis', 'Neoplasms, Multiple Primary', 'Thyroid Neoplasms', 'Thyroidectomy'] | 3,798,839 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['C04.557.386', 'C15.604.515.569', 'C20... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A novel class of anti-DNA antibodies identified in BALB/c mice. | We have characterized four IgG monoclonal antibodies (mAbs) derived from BALB/c mice that bind double-stranded DNA (dsDNA) with high affinity. The hydridomas were selected for expression of a member of the VHS107 family. Three of the four cell lines use the VH11 gene and one uses the VH1 gene. These antibodies exhibit ... | ['Amino Acid Sequence', 'Animals', 'Antibodies, Antinuclear', 'Antibodies, Monoclonal', 'Base Sequence', 'Carrier Proteins', 'Cross Reactions', 'DNA', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Genes, Immunoglobulin', 'Hybridomas', 'Immunization', 'Immunoblotting', 'Immunoglobulin G', 'Immunoglobulin Variable Regi... | 1,988,536 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.323.204', 'D12.776.124.790.651.114.323.204', 'D12.776.377.715.548.114.323.204'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Bioinformatics Assembling and Assessment of Novel Coxsackievirus B1 Genome. | The human microbiome project via application of metagenomic next-generation sequencing techniques has found surprising large and diverse amounts of microbial sequences across different body sites. There is a wave of investigators studying autoimmune related diseases designing from birth case and control studies to eluc... | ['Computational Biology', 'Enterovirus B, Human', 'Genome, Viral', 'Genomics', 'Humans', 'Metagenome', 'Metagenomics', 'Quality Control'] | 30,129,002 | [['H01.158.273.180', 'L01.313.124'], ['B04.820.578.750.284.182'], ['G05.360.340.358.840'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.360.340.550'], ['H01.158.273.343.350.261'], ['J01.897.608']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Care diaries: a way of increasing head and neck cancer patient's involvement in their own care and the communication between clinicians. | Head and neck (H&N) cancer patients and their families meet a large number of clinicians during their long treatment period and many of them find it difficult to understand all the information given concerning their illness, treatment, and care. We have developed a care diary for these patients and their families, used... | ['Adult', 'Attitude of Health Personnel', 'Communication', 'Family', 'Female', 'Forms and Records Control', 'Head and Neck Neoplasms', 'Health Personnel', 'Humans', 'Interprofessional Relations', 'Male', 'Middle Aged', 'Needs Assessment', 'Nursing Evaluation Research', 'Nursing Methodology Research', 'Nursing Records',... | 15,253,169 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['F01.145.209', 'L01.143'], ['F01.829.263', 'I01.880.853.150'], ['N04.452.758.708.200.400'], ['C04.588.443'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['M01.060.116.630'], ['I02.594', 'N03.349.380.565', 'N05.300.5... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [... | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Long-term exogenous melatonin treatment modulates overall feed efficiency and protects ovarian tissue against injuries caused by ethanol-induced oxidative stress in adult UChB rats. | BACKGROUND: Chronic ethanol intake leads to reproductive damage including reactive oxygen species formation, which accelerates the oxidative process. Melatonin is known to regulate the reproductive cycle, food/liquid intake, and it may also act as a potent antioxidant indoleamine. The aim of this study was to verify th... | ['Alcohol Drinking', 'Animals', 'Antioxidants', 'Body Weight', 'Central Nervous System Depressants', 'Estrous Cycle', 'Ethanol', 'Feeding Behavior', 'Female', 'Glycemic Index', 'Injections, Intraperitoneal', 'Melatonin', 'Ovary', 'Oxidative Stress', 'Protective Agents', 'Rats', 'Reactive Oxygen Species', 'Superoxide Di... | 21,438,888 | [['F01.145.317.269'], ['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D27.505.696.277', 'D27.505.954.427.210'], ['G08.686.195'], ['D02.033.375'], ['F01.145.113.547', 'F01.14... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
The human hepatocyte cell lines IHH and HepaRG: models to study glucose, lipid and lipoprotein metabolism. | Metabolic diseases reach epidemic proportions. A better knowledge of the associated alterations in the metabolic pathways in the liver is necessary. These studies need in vitro human cell models. Several human hepatoma models are used, but the response of many metabolic pathways to physiological stimuli is often lost. ... | ['Apolipoproteins B', 'Cell Line', 'Colforsin', 'Gene Expression Regulation', 'Gluconeogenesis', 'Glucose', 'Glycolysis', 'Hepatocytes', 'Humans', 'Insulin', 'Lipid Metabolism', 'Models, Biological', 'RNA, Small Interfering', 'Transfection'] | 22,594,799 | [['D10.532.091.300', 'D12.776.070.400.300', 'D12.776.521.120.300'], ['A11.251.210'], ['D02.455.849.291.300'], ['G05.308'], ['G02.111.158.500', 'G03.191.500'], ['D09.947.875.359.448'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['A11.436.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D0... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A phase I study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer. | INTRODUCTION: This investigator-initiated study explores the safety, maximum tolerated dose, clinical response, and pharmacokinetics of hydroxychloroquine (HCQ) with and without erlotinib in patients with advanced non-small-cell lung cancer.METHODS: Patients with prior clinical benefit from an epidermal growth factor r... | ['Adenocarcinoma', 'Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Carcinoma, Non-Small-Cell Lung', 'Enzyme Inhibitors', 'ErbB Receptors', 'Everolimus', 'Female', 'Follow-Up Studies', 'Humans', 'Hydroxychloroquine', 'Immunosuppressive Agents', 'Lung Neoplasms', 'Male', 'Maximum Tolerated Dose', 'Mid... | 22,878,749 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['D27.505.519.389'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.4... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Factors influencing central line infections in children with acute lymphoblastic leukemia: results of a single institutional study. | BACKGROUND: We compared the rates of infection in external catheters (ECs) and totally implantable devices (TIDs) and the effect of timing of insertion in children with acute lymphoblastic leukemia (ALL).PROCEDURE: Central line data was collected on all children with ALL referred to the National Guard Hospital, Jeddah.... | ['Age Factors', 'Antineoplastic Combined Chemotherapy Protocols', 'Catheterization, Central Venous', 'Child', 'Child, Preschool', 'Equipment Design', 'Female', 'Humans', 'Infections', 'Male', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Retrospective Studies', 'Risk Factors', 'Time Factors'] | 14,966,828 | [['N05.715.350.075', 'N06.850.490.250'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E02.148.167', 'E04.100.814.529.875', 'E04.502.382.875', 'E05.157.313'], ['M01.060.406'], ['M01.060.406.448'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01'], ['C04.557.337.428.600', 'C15.604.515.... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of formulation properties on chemical stability of captopril in aqueous preparations. | The influence of various formulation properties on the chemical stability of captopril in aqueous media at pH 3 was investigated, in order to reformulate and increase the shelf-life of an oral mixture of the drug. At this pH, chemical stability is improved by an increase in drug concentration (1-5 mg/ml) and a decrease... | ['Angiotensin-Converting Enzyme Inhibitors', 'Buffers', 'Captopril', 'Catalysis', 'Chelating Agents', 'Chemistry, Pharmaceutical', 'Chromatography, High Pressure Liquid', 'Drug Stability', 'Drug Storage', 'Excipients', 'Hot Temperature', 'Hydrogen-Ion Concentration', 'Oxygen', 'Protons', 'Solutions', 'Solvents', 'Spect... | 19,177,902 | [['D27.505.519.389.745.085'], ['D27.720.470.280'], ['D12.125.072.401.623.270'], ['G02.130'], ['D27.505.519.914.500', 'D27.720.832.500'], ['H01.158.703.007', 'H01.181.466'], ['E05.196.181.400.300'], ['E05.916.330'], ['E05.916.350'], ['D26.650.700.419', 'D27.720.744.770.419'], ['G01.906.595.543', 'G16.500.275.063.725.710... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[Conflict management in the workplace]. | Our sanitary system and our health organizations have to confront the conflicts which have derived from the successive social and sanitary changes which have developed over the most recent decades. These new realities in the health fields oblige the professionals dedicated to them, the administrators of our organizatio... | ['Conflict, Psychological', 'Dissent and Disputes', 'Health Personnel', 'Humans', 'Negotiating', 'Workplace'] | 20,387,409 | [['F01.658.209'], ['F01.829.401.094', 'F02.463.785.373.476'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.520', 'F01.829.401.520', 'F02.463.785.373.520', 'L01.143.620', 'N04.452.677.430'], ['N01.824.245.925', 'N04.452.677.975']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Comparative analysis of the epidemiology of amyotrophic lateral sclerosis in the province of Poznan]. | In the Province of Pozna? on the point day Dec 31 1986 the prevalence of lateral amyotrophic sclerosis was found to be 1.9 per 100 thousand and the incidence in 1986 was 1.1 per 100 thousand. In relation to a similar study in 1965 these results are insufficient for accepting a change in the prevalence of amyotrophic la... | ['Adult', 'Amyotrophic Lateral Sclerosis', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Poland', 'Prevalence'] | 2,131,426 | [['M01.060.116'], ['C10.228.854.139', 'C10.574.562.250', 'C10.574.950.050', 'C10.668.467.250', 'C18.452.845.800.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.116.630'], ['Z01.542.248.679... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Human nucleoside diphosphate kinase B (Nm23-H2) from melanoma cells shows altered phosphoryl transfer activity due to the S122P mutation. | The Ser122 --> Pro mutation in human nucleoside diphosphate kinase (NDK)-B/Nm23-H2 was recently found in melanoma cells. In comparison to the wild-type enzyme, steady state activity of NDKS122P with ATP and TDP as substrates was slowed down 5-fold. We have utilized transient kinetic techniques to analyze phosphoryl tra... | ['Adenosine Triphosphate', 'Base Sequence', 'DNA Primers', 'Guanosine Triphosphate', 'Humans', 'Melanoma', 'Monomeric GTP-Binding Proteins', 'Mutation', 'NM23 Nucleoside Diphosphate Kinases', 'Nucleoside-Diphosphate Kinase', 'Phosphorylation', 'Transcription Factors', 'Tumor Cells, Cultured'] | 10,400,630 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D03.633.100.759.646.454.504', 'D13.695.667.454.504', 'D13.695.827.426.504'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
In vitro T cell-mediated killing of Pseudomonas aeruginosa. IV. Nonresponsiveness in polysaccharide-immunized BALB/c mice is attributable to vinblastine-sensitive suppressor T cells. | We reported previously that BALB/c mice immunized with a polysaccharide (PS) antigen isolated from immunotype 1 Pseudomonas aeruginosa and vinblastine sulfate develop T cell-mediated protective immunity, despite their failure to produce specific antibody. In vitro, Lyt-1-,2+, I-J+ T cells from vinblastine- and PS-immun... | ['Animals', 'Antigens, Differentiation, T-Lymphocyte', 'Antigens, Ly', 'Antigens, Surface', 'Blood Bactericidal Activity', 'Cyclophosphamide', 'Immune Tolerance', 'Immunity, Cellular', 'Mice', 'Mice, Inbred BALB C', 'Polysaccharides, Bacterial', 'Pseudomonas aeruginosa', 'Suppressor Factors, Immunologic', 'T-Lymphocyte... | 2,943,808 | [['B01.050'], ['D23.050.301.264.894', 'D23.101.100.894'], ['D23.050.301.264.920', 'D23.101.100.920'], ['D23.050.301'], ['G09.188.100', 'G12.450.564.204'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['G12.535.425'], ['G12.450.050.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessment of arterial stiffness and cardiovascular hemodynamics by oscillometric method in psoriasis patients with normal cardiac functions. | Arterial stiffness is associated with increased cardiovascular risk. Pulse wave velocity (PWV) and augmentation index (AIx) are non-invasive markers for assessment of arterial stiffness. Increased arterial stiffness is associated with atherosclerosis in patients with psoriasis. Previous studies have shown that high neu... | ['Adult', 'Cardiovascular Diseases', 'Case-Control Studies', 'Chi-Square Distribution', 'Cross-Sectional Studies', 'Early Diagnosis', 'Female', 'Heart Rate', 'Hemodynamics', 'Humans', 'Linear Models', 'Logistic Models', 'Lymphocyte Count', 'Lymphocytes', 'Male', 'Middle Aged', 'Neutrophils', 'Odds Ratio', 'Oscillometry... | 24,633,494 | [['M01.060.116'], ['C14'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E01.390'], ['E01.370.600.875.500', 'G09... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Vittorio Benussi and experimental psychoanalysis]. | This essay proposes to reconstruct the project of experimental psychoanalysis initiated by Vittorio Benussi in the Psychology Laboratory of the University of Padua between 1919 and 1927. For Benussi, the language of the unconscious never refers back to an experimental or psychoanalytical context, but always to a possib... | ['Biomedical Research', 'History, 20th Century', 'Italy', 'Psychoanalysis'] | 21,657,090 | [['H01.770.644.145'], ['K01.400.504.968'], ['Z01.542.489'], ['F04.096.544.779']] | ['Disciplines and Occupations [H]', 'Humanities [K]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
[Detection of tumor cells in peripheral blood for patients with ovarian epithelial carcinoma]. | OBJECTIVE: To detect tumor cell contamination of peripheral blood stem cell (PBSC) and the presence of tumor cells in peripheral circulating blood in patients with primary advanced ovarian cancer.METHODS: To establish limits of sensitivity of the immunocytochemical stainings technique (ABC method) for tumor cell detect... | ['Adenocarcinoma', 'Aged', 'Cystadenocarcinoma, Papillary', 'Female', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Middle Aged', 'Neoplastic Cells, Circulating', 'Ovarian Neoplasms'] | 11,326,940 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['C04.557.470.200.025.480.230', 'C04.557.470.590.480.230'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A11.642', 'C04.697.650.900', 'C23.550.727.650.900'], ['C04.588.322.455', 'C13.351.500.056... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lamin A is not synthesized as a larger precursor polypeptide. | Isolation of rat liver nuclei in the presence of N-ethylmaleimide (NEM) led to the recovery in the final nuclear matrix of a higher molecular weight form of lamin A. The 2 kDa larger form was identified as lamin A by isoelectric point determination, recognition by an anti-lamin A and C monoclonal antibody and peptide m... | ['Animals', 'Cells, Cultured', 'Ethylmaleimide', 'Lamin Type A', 'Lamins', 'Male', 'Molecular Weight', 'Nuclear Proteins', 'Protein Precursors', 'Rats', 'Rats, Inbred Strains'] | 3,426,582 | [['B01.050'], ['A11.251'], ['D02.241.081.337.502.524.418', 'D02.478.440.418', 'D03.383.129.578.399.418'], ['D12.776.660.650.875.500'], ['D12.776.660.650.875'], ['G02.494'], ['D12.776.660'], ['D12.776.811'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of dietary eugenol on xenobiotic metabolism and mediation of UDP-glucuronosyltransferase and cytochrome P450 1A1 expression in rat liver. | Xenobiotic-metabolizing enzymes (XMEs) play an important role in the elimination and detoxification of xenobiotics and drugs. A variety of natural dietary agents are known to protect against cancer by inducing XME. To elucidate the molecular mechanism of XME induction, we examined the effect of dietary eugenol (4-allyl... | ['Animals', 'Cytochrome P-450 CYP1A1', 'Diet', 'Drug Interactions', 'Eugenol', 'Glucuronosyltransferase', 'Glutathione Transferase', 'Liver', 'Male', 'Neoplasms', 'Phytotherapy', 'Plant Extracts', 'Rats', 'Rats, Sprague-Dawley', 'Xenobiotics'] | 24,144,396 | [['B01.050'], ['D08.244.453.005.332', 'D08.244.453.100.500', 'D08.811.682.690.708.170.010.277', 'D08.811.682.690.708.170.020.500', 'D12.776.422.220.453.010.332', 'D12.776.422.220.453.100.500'], ['G07.203.650.240'], ['G07.690.773.968'], ['D02.241.223.200.054.500'], ['D08.811.913.400.450.480'], ['D08.811.913.225.500'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial. | BACKGROUND: Extensive distribution of the different components of renin angiotensin system (RAS) in the brain, along with their roles in promoting anxiety, depression and brain inflammation, opposes RAS as a potential therapeutic target in major depression. Actions of angiotensin II, the main product of RAS, are reduce... | ['Adolescent', 'Adult', 'Aged', 'Alleles', 'Antidepressive Agents', 'Depressive Disorder, Major', 'Female', 'Fluoxetine', 'Genotype', 'Humans', 'Male', 'Middle Aged', 'Peptidyl-Dipeptidase A', 'Polymorphism, Genetic', 'Sertraline', 'Young Adult'] | 27,262,302 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['G05.360.340.024.340.030'], ['D27.505.954.427.700.122'], ['F03.600.300.375'], ['D02.092.831.280'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D08.811.277.656.350.350.687'], ['G05.365.795'], ['D02.092.705.800', 'D02.455.42... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Proliferative hippocampal activity in a group of patients with Rasmussen's encephalitis: Neuronal, glial, and BDNF tissue expression correlations. | Rasmussen's encephalitis (RE) is a rare and devastating unilateral inflammatory brain disease that causes severe and intractable partial epilepsy. It has been shown that epilepsy and subsequent inflammation have deleterious influence on hippocampal cell survival and neurogenesis, but this still has not been systematica... | ['Brain-Derived Neurotrophic Factor', 'Case-Control Studies', 'Cell Proliferation', 'Child', 'Child, Preschool', 'Dentate Gyrus', 'Encephalitis', 'Female', 'Gene Expression', 'Hippocampus', 'Humans', 'Male', 'Neuroglia', 'Neurons', 'Tissue Distribution'] | 29,579,552 | [['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G04.161.750', 'G07.345.249.410.750'], ['M01.060.406'], ['M01.060.406.448'], ['A08.186.211.180.405.200', 'A08.186.211.200.885.287.500.345.200'], ['C1... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Purine metabolism of the human erythrocyte]. | Purine metabolism has been much investigated in human erythrocytes, both for the interest focused on this peculiar cell biochemistry, and four purine pathological implications in man. Most mammalian red blood cells lack de novo purine synthesis, and are completely dependent on base salvage pathway for their purine nucl... | ['Adenosine', 'Erythrocyte Membrane', 'Erythrocytes', 'Humans', 'Inosine', 'Kinetics', 'Pentosyltransferases', 'Phosphoribosyl Pyrophosphate', 'Phosphorylation', 'Phosphotransferases', 'Purine Nucleosides', 'Purine Nucleotides', 'Purines', 'Ribose-Phosphate Pyrophosphokinase'] | 6,201,946 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.759.590.616', 'D13.570.583.616', 'D13.570.800.573'], ['G01.374.661', 'G02.1... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prophylaxis of postoperative nausea and vomiting after cardiac surgery in high-risk patients: A randomized controlled study. | CONTEXT: The role of prophylaxis for postoperative nausea and vomiting (PONV) in cardiac surgery is under debate.AIMS: To study the risk factors for PONV after cardiac surgery and the role of betamethasone with or without droperidol for its prevention.SETTING AND DESIGN: Randomized open-label controlled study comparing... | ['Aged', 'Cardiac Surgical Procedures', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pain Management', 'Pain, Postoperative', 'Postoperative Nausea and Vomiting', 'Risk Factors'] | 29,336,385 | [['M01.060.116.100'], ['E04.100.376', 'E04.928.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.745', 'N04.590.607.500'], ['C23.550.767.700', 'C23.888.592.612.832'], ['C23.550.767.859', 'C23.888.821.712.700', 'C23.888.821.937.059'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Sexual activity in the convalescent from acute myocardial infarct. Bibliographic review]. | There is little information in the medical literature about the renewal of sexual activity in patients who have suffered an MI. The knowledge which the internist and the cardiologist have are normally insufficient. The equivalents in energetic cost of a sexual relation of a middle aged adult, are similar to those of: a... | ['Adult', 'Coitus', 'Convalescence', 'Female', 'Humans', 'Male', 'Myocardial Infarction', 'Physician-Patient Relations', 'Sexual Abstinence'] | 931,450 | [['M01.060.116'], ['F01.145.802.188', 'G08.686.784.041'], ['C23.550.291.562'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['F01.829.401.650.675', 'N05.300.660.625'], ['F01.145.802.900']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pre-treatment Elevated Platelet Count Associates with HER2 Overexpression and Prognosis in Patients with Breast Cancer. | PURPOSE: To research the association between pre-treatment elevated platelet count and clinicopathologic characteristics in breast cancer (BC), as well as explore the relationship between pre-treatment elevated platelet count and HER2 status and prognosis of BC patients.MATERIALS AND METHODS: A retrospective cohort of ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Blood Platelets', 'Breast Neoplasms', 'Female', 'Follow-Up Studies', 'Humans', 'Middle Aged', 'Neoplasm Staging', 'Platelet Count', 'Prognosis', 'Receptor, ErbB-2', 'Receptors, Estrogen', 'Receptors, Progesterone', 'Retrospective Studies', 'Survival Rate', 'Young Adult'] | 26,225,707 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A11.118.188', 'A15.145.229.188'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.625'], ['E01.... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Micro-Shuttle Lifting of the Neck: A Percutaneous Loop Suspension Method Using a Novel Double-Ended Needle. | BACKGROUND: Most younger patients expect to be able to achieve significant improvements and lift to their neck, yet they don't want to undergo extensive surgery. They are now able to do that and restore their youthful appearance thanks to new concepts the techniques through volume redistribution.OBJECTIVES: The authors... | ['Adult', 'Anesthesia, Local', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Minimally Invasive Surgical Procedures', 'Neck', 'Needles', 'Patient Satisfaction', 'Rejuvenation', 'Rhytidoplasty', 'Skin Aging', 'Suture Techniques'] | 26,906,348 | [['M01.060.116'], ['E03.155.086.231'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.502'], ['A01.598'], ['E07.612'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', 'N05.300.150.80... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The detection and characterization of vesicoureteral reflux in the child. | Voiding cystourethrography or radionuclide cystography should be performed in the child in whom it is important to know whether reflux is present. Voiding cystourethrography is more accurate in characterizing and grading reflux, and monitoring is intermittent. Conversely, radionuclide cystography uses a lower radiation... | ['Child', 'Female', 'Humans', 'Male', 'Radiography', 'Radionuclide Imaging', 'Urethra', 'Urinary Bladder', 'Vesico-Ureteral Reflux'] | 1,433,579 | [['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700'], ['E01.370.350.710', 'E01.370.384.730'], ['A05.360.444.492.726', 'A05.810.876'], ['A05.810.890'], ['C12.777.829.920', 'C13.351.968.829.920']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Electrophysiological analysis of pathways connecting the medial preoptic area with the mesencephalic central grey matter in rats. | 1. An electrophysiological study of ascending and descending connexions between the dorsal raphe region of the mesencephalic periaqueductal grey matter and the medial preoptic area has been performed in dioestrous female rats anaesthetized with urethane. 2. Extracellular action potentials recorded from 208 neurones in ... | ['Action Potentials', 'Animals', 'Brain Stem', 'Diestrus', 'Evoked Potentials', 'Female', 'Hypothalamus', 'Neural Conduction', 'Neural Inhibition', 'Neural Pathways', 'Neurons', 'Pregnancy', 'Preoptic Area', 'Raphe Nuclei', 'Rats'] | 7,188,967 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['A08.186.211.132'], ['G08.686.195.374'], ['G07.265.216.500', 'G11.561.200.500'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['G07.265.753', 'G11.561.601'], ['G07.265.755', 'G11.561.616'], ['A08.612'], ['A08.675', 'A11.671'], ['G08.686.784.76... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Assessment of smoking cessation assistance in French pharmacies]. | INTRODUCTION: While smoking continues to kill 73,000 people each year in France, new legislation allows pharmacists to ensure public health actions. How do pharmacists contribute to smoking cessation?METHODS: This study described smoking cessation professional practices, the tests used and dispensing of nicotine replac... | ['Adult', 'Female', 'France', 'Humans', 'Male', 'Middle Aged', 'Pharmaceutical Services', 'Pharmacists', 'Professional Role', 'Public Health', 'Smoking Cessation', 'Smoking Prevention', 'Surveys and Questionnaires', 'Young Adult'] | 26,414,029 | [['M01.060.116'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N02.421.668'], ['M01.526.485.780', 'N02.360.780'], ['F01.829.316.616.625'], ['H02.403.720', 'N01.400.550', 'N06.850'], ['F01.145.488.732'], ['I02.233.332.812', 'N02.421.726.407.840'], ['E05.318.308.980', 'N05.715.... | ['Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Antimicrobial activity of AmBisome and non-liposomal amphotericin B following uptake of Candida glabrata by murine epidermal Langerhans cells. | The antifungal efficacy and cellular toxicity of AmBisome(R) and non-liposomal amphotericin B were compared in cultured epidermal Langerhans cells infected with Candida glabrata. Uptake of the yeast was determined by light and electron microscopy, and viability was assessed by plating dilutions of lysates from yeast-in... | ['Amphotericin B', 'Animals', 'Animals, Newborn', 'Antifungal Agents', 'Candida', 'Cells, Cultured', 'Langerhans Cells', 'Liposomes', 'Mice'] | 9,776,826 | [['D02.540.576.500.500'], ['B01.050'], ['B01.050.050.282'], ['D27.505.954.122.136'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['A11.251'], ['A11.066.270.500', 'A11.436.270.545', 'A15.382.066.270.500', 'A15.382.670.260.500'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.50... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A new species of Haplophyllum A. Juss. (Rutaceae) from the Iberian Peninsula: evidence from morphological, karyological and molecular analyses. | BACKGROUND AND AIMS: The discovery of a new species, Haplophyllum bastetanum F.B. Navarro, V.N. Su?rez-Santiago & Blanca sp. nov., in the south-east of Spain has prompted the comparative study of species of the Iberian Peninsula, and others related, through morphological, cytogenetic, molecular, distributional and ecol... | ['Base Sequence', 'Biological Evolution', 'DNA, Intergenic', 'DNA, Plant', 'Flowers', 'Fruit', 'Phenotype', 'Phylogeny', 'Plant Leaves', 'Plant Stems', 'Ploidies', 'Rutaceae', 'Seeds', 'Spain', 'Species Specificity'] | 15,306,560 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G05.045', 'G16.075'], ['D13.444.308.324', 'G05.360.340.024.220'], ['D13.444.308.435'], ['A18.024.249.500'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['G05.695'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['A18.024.812'], ['A18.024.937'], ['G05.700... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 |
[The influence of dehydrocorydaline on intracellular free calcium concentration during hypoxia in myocardial cell of guinea-pigs]. | AIM: To study the effect of Dehydrocorydaline and Verapamil (Ver) on intracellular free calcium concentration of myocardial cell ([Ca2+]i) under hypoxic condition.METHODS: We adopted guinea-pig heart Langendorff instillation. The myocardial cells were isolated by collagenase (Type I, sigma)and marked by fluorescence ra... | ['Alkaloids', 'Animals', 'Calcium', 'Cell Hypoxia', 'Female', 'Guinea Pigs', 'Male', 'Myocytes, Cardiac'] | 21,189,579 | [['D03.132'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G03.197.300', 'G04.270.300'], ['B01.050.150.900.649.313.992.550'], ['A07.541.704.570', 'A10.690.552.750.570', 'A11.620.500']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Cystic degeneration of the tunica adventitia of the popliteal artery]. | INTRODUCTION: Adventitial cystic disease of the popliteal artery (PA) is an uncommon and unique entity characterized by a mucinous cyst located in the arterial adventitia. As the cyst enlarges, it provokes vascular compression with stenosis or occlusion, the first only during the knee flexion, and then in all leg posit... | ['Adult', 'Cysts', 'Female', 'Humans', 'Male', 'Middle Aged', 'Popliteal Artery', 'Popliteal Cyst', 'Vascular Diseases'] | 9,863,387 | [['M01.060.116'], ['C04.182', 'C23.300.306'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.015.114.681'], ['C04.182.867.500'], ['C14.907']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Improving lysine production by Corynebacterium glutamicum through DNA microarray-based identification of novel target genes. | For the biotechnological production of L: -lysine, mainly strains of Corynebacterium glutamicum are used, which have been obtained by classical mutagenesis and screening or selection or by metabolic engineering. Gene targets for the amplification and deregulation of the lysine biosynthesis pathway, for the improvement ... | ['Aspartate Kinase', 'Base Sequence', 'Biotechnology', 'Corynebacterium glutamicum', 'DNA, Bacterial', 'Feedback', 'Gene Expression', 'Gene Expression Profiling', 'Genes, Bacterial', 'Lysine', 'Mutation', 'Oligonucleotide Array Sequence Analysis', 'Plasmids'] | 17,364,200 | [['D08.811.913.696.630.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['H01.158.550', 'J01.897.120'], ['B03.510.024.250.300', 'B03.510.460.400.400.200.300'], ['D13.444.308.212'], ['L01.906.394.211'], ['G05.297'], ['E05.393.332'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Novel biosensor chip for simultaneous detection of DNA-carcinogen adducts with low-temperature fluorescence. | A monoclonal antibody (MAb)-gold biosensor chip with low-temperature laser-induced fluorescence detection for analysis of DNA-carcinogen adducts is described. Optimization of the detection limit, dynamic range, and biosensing applicability of the MAb-gold biosensor chip was achieved by: (1) using dithiobis(succinimidyl... | ['Benzo(a)pyrene', 'Benzopyrenes', 'Biosensing Techniques', 'Carcinogens', 'Cold Temperature', 'DNA Adducts', 'Equipment Design', 'Equipment Failure Analysis', 'Fluoroimmunoassay', 'Guanine', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Spectrometry, Fluorescence'] | 14,683,638 | [['D02.455.426.559.847.799.306.300', 'D04.615.799.306.300'], ['D02.455.426.559.847.799.306', 'D04.615.799.306'], ['E05.601.043'], ['D27.888.569.100'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['D13.444.308.135', 'G05.200.104... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Risk-based cost-benefit analysis for evaluating microbial risk mitigation in a drinking water system. | Waterborne outbreaks of gastrointestinal diseases can cause large costs to society. Risk management needs to be holistic and transparent in order to reduce these risks in an effective manner. Microbial risk mitigation measures in a drinking water system were investigated using a novel approach combining probabilistic r... | ['Cost-Benefit Analysis', 'Decision Support Techniques', 'Disinfection', 'Drinking Water', 'Humans', 'Risk Assessment', 'Sweden', 'Ultraviolet Rays', 'Waste Disposal, Fluid', 'Waste Water', 'Water Purification'] | 29,316,514 | [['N03.219.151.125'], ['E05.245', 'L01.313.500.750.190'], ['N06.850.780.200.450.850.375'], ['D01.045.250.875.300', 'D01.248.497.158.459.650.300', 'D01.650.550.925.199', 'G07.203.100.418', 'J02.200.418'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Pharmacokinetics of efavirenz (EFV) alone and in combination therapy with nelfinavir (NFV) in HIV-1 infected patients. | AIMS: To define the pharmacokinetic profile of efavirenz (EFV) in HIV-1 infected patients, when administered alone or with nelfinavir (NFV).METHODS: Eleven HIV-positive patients, in steady-state treatment with EFV and 11 patients in steady-state treatment with EFV+NFV, were evaluated. Blood samples for pharmacokinetic ... | ['Adult', 'Alkynes', 'Anti-HIV Agents', 'Area Under Curve', 'Benzoxazines', 'Chromatography, High Pressure Liquid', 'Cyclopropanes', 'Female', 'HIV Infections', 'HIV-1', 'Humans', 'Male', 'Nelfinavir', 'Oxazines', 'Spectrophotometry, Ultraviolet'] | 10,594,473 | [['M01.060.116'], ['D02.455.326.397'], ['D27.505.954.122.388.077.088'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D03.383.533.249', 'D03.633.100.209'], ['E05.196.181.400.300'], ['D02.455.426.392.368.533'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.8... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Endoscopic capsule placement improves the completion rate of small-bowel capsule endoscopy and increases diagnostic yield. | BACKGROUND: The methods for increasing the rate of complete small-bowel examinations by capsule endoscopy (CE) demonstrate conflicting results, and it is unknown whether improving the completion rate of CE transit is correlated with improvement in diagnostic yield.OBJECTIVE: The aim of this study was to determine wheth... | ['Adult', 'Aged', 'Capsule Endoscopy', 'Case-Control Studies', 'Diagnosis, Computer-Assisted', 'Endoscopy, Gastrointestinal', 'Equipment Design', 'Female', 'Gastrointestinal Transit', 'Humans', 'Image Interpretation, Computer-Assisted', 'Intestinal Diseases', 'Intestine, Small', 'Male', 'Middle Aged', 'Sensitivity and ... | 20,304,397 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.388.250.250.250.140'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.158', 'L01.313.500.750.100.158'], ['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04.210.240.250', 'E04.502.250.250.250'], ['E05.320'], ['E01.370.372.310', 'G... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Lysosomal acid phosphatase: difference between normal and chronic lymphocytic leukaemia T and B lymphocytes. | Lysosomal acid phosphatase was assayed in homogenates of isolated normal and B cell type chronic lymphocytic leukaemia (B-CLL) T and B lymphocytes by biochemical means. Unlike the results of cytochemical studies reported in the literature enzyme activity was considerably higher in normal B lymphocytes than in correspon... | ['Acid Phosphatase', 'B-Lymphocytes', 'Cell-Free System', 'Humans', 'Leukemia, Lymphoid', 'Lysosomes', 'Methods', 'T-Lymphocytes'] | 1,086,689 | [['D08.811.277.352.650.025'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A11.284.835.168'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.428', 'C15.604.515.560', 'C20.683.515.528'], ['A11.284.430.214.190.875.190.550'], ['E... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bioreactivity of stent material: Activation of platelets, coagulation, leukocytes and endothelial cell dysfunction in vitro. | Outcome of patients with coronary artery disease has been significantly improved by percutaneous coronary interventions with stent implantation. However, despite progress made on devices and antithrombotic treatments, stent thrombosis remains an important issue because of serious adverse consequences. Several mechanism... | ['Blood Coagulation', 'Blood Platelets', 'Chromium Alloys', 'Endothelial Cells', 'Humans', 'Leukocytes', 'Materials Testing', 'Stents'] | 28,032,527 | [['G09.188.390.150'], ['A11.118.188', 'A15.145.229.188'], ['D01.220.175', 'D01.552.033.182', 'D25.058.224', 'D25.339.208.224', 'J01.637.051.058.224', 'J01.637.051.339.208.224'], ['A11.436.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['E05.570'], ['E07.695.75... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection. | Antibodies are promising post-exposure therapies against emerging viruses, but which antibody features and in vitro assays best forecast protection are unclear. Our international consortium systematically evaluated antibodies against Ebola virus (EBOV) using multidisciplinary assays. For each antibody, we evaluated epi... | ['Animals', 'Antibodies, Monoclonal', 'Ebolavirus', 'Epitopes', 'Female', 'Hemorrhagic Fever, Ebola', 'Immunization', 'Membrane Glycoproteins', 'Mice', 'Mice, Inbred BALB C', 'Treatment Outcome'] | 30,096,313 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['B04.820.480.937.300.200'], ['D23.050.550'], ['C01.925.782.417.415', 'C01.925.782.580.250.400'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.680.310'], ['D1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Sialyl-Tn Polysaccharide A1 as an Entirely Carbohydrate Immunogen: Synthesis and Immunological Evaluation. | Sialyl Thomsen-nouveau (STn) is a tumor-associated carbohydrate antigen (TACA) that is overexpressed in a variety of carcinomas such as breast, ovarian, and colon cancer. In normal tissue, STn is not detectable, which is critical for opportunities in developing cancer immunotherapies. A novel, entirely carbohydrate, se... | ['Animals', 'Antigens, Tumor-Associated, Carbohydrate', 'Chemistry Techniques, Synthetic', 'Humans', 'MCF-7 Cells', 'Mice', 'Oximes', 'Polysaccharides'] | 27,726,393 | [['B01.050'], ['D23.050.285.050', 'D23.050.550.325', 'D23.101.140.075'], ['E05.197', 'J01.897.836.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.630'], ['B01.050.150.900.649.313.992.635.505.500'], ['D02.092.570.665'], ['D09.698']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle. | To study the peripheral effects of melanocortin on fuel homeostasis in skeletal muscle, we assessed palmitate oxidation and AMP kinase activity in alpha-melanocyte-stimulating hormone (alpha-MSH)-treated muscle cells. After alpha-MSH treatment, carnitine palmitoyltransferase-1 and fatty acid oxidation (FAO) increased i... | ['Animals', 'Cells, Cultured', 'DNA Primers', 'Fatty Acids', 'Hindlimb', 'Kinetics', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mitochondria, Muscle', 'Muscle, Skeletal', 'Myoblasts', 'Oxidation-Reduction', 'Receptor, Melanocortin, Type 1', 'Recombinant Proteins', 'Reverse Transcriptase Polymerase Chain Reaction', 'alpha-M... | 17,127,674 | [['B01.050'], ['A11.251'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D10.251'], ['A13.473'], ['G01.374.661', 'G02.111.490'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['A11.284.430.214.190.875.564.627', 'A11.284.8... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The secular growth acceleration: does it appear during fetal life? | OBJECTIVE: To test if secular growth acceleration occurs during fetal life.METHODS: ANOVA Kruskal-Wallis and Mann-Whitney U-test have been used for the biometric characteristics comparison of nowadays fetal population with those three decades ago and to test the hypothesis about the existence of secular growth accelera... | ['Acceleration', 'Birth Weight', 'Female', 'Fetal Development', 'Gestational Age', 'Humans', 'Infant, Newborn', 'Population Growth', 'Pregnancy', 'Reference Values', 'Ultrasonography, Prenatal'] | 24,446,763 | [['G01.482.107'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['G07.345.500.325.235', 'G08.686.784.170.157'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['I... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Correlation Between Chain Architecture and Hydration Water Structure in Polysaccharides. | The physical properties of confined water can differ dramatically from those of bulk water. Hydration water associated with polysaccharides provides a particularly interesting example of confined water, because differences in polysaccharide structure provide different spatially confined environments for water sorption.... | ['Chitosan', 'Glycogen', 'Hyaluronic Acid', 'Hydrophobic and Hydrophilic Interactions', 'Water'] | 26,859,153 | [['D05.750.078.139.500', 'D09.698.211.500'], ['D05.750.078.562.388', 'D09.698.365.388'], ['D09.698.373.475'], ['G02.409'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Over-selectivity as a learned response. | An experiment investigated the effects of different levels of task complexity in pre-training on over-selectivity in a subsequent match-to-sample (MTS) task. Twenty human participants were divided into two groups; exposed either to a 3-element, or a 9-element, compound stimulus as a sample during MTS training. After th... | ['Adaptation, Psychological', 'Adult', 'Choice Behavior', 'Conditioning, Psychological', 'Cues', 'Discrimination Learning', 'Female', 'Humans', 'Male', 'Models, Statistical', 'Pattern Recognition, Visual', 'Photic Stimulation', 'Reference Values'] | 20,951,544 | [['F01.058'], ['M01.060.116'], ['F02.463.785.373.346'], ['F02.463.425.179'], ['F02.463.425.234'], ['F02.463.425.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['E05.723.729'], ['E05... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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