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X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state at 2.0 ? resolution. | The X-ray structure of cyanide-bound bovine heart cytochrome c oxidase in the fully oxidized state was determined at 2.0 ? resolution. The structure reveals that the peroxide that bridges the two metals in the fully oxidized state is replaced by a cyanide ion bound in a nearly symmetric end-on fashion without significa... | ['Animals', 'Binding Sites', 'Cattle', 'Crystallization', 'Crystallography, X-Ray', 'Electron Transport Complex IV', 'Mitochondria, Heart', 'Models, Molecular', 'Myocardium', 'Oxidation-Reduction', 'Potassium Cyanide', 'Protein Binding', 'Protein Structure, Secondary', 'Protein Structure, Tertiary'] | 26,057,802 | [['B01.050'], ['G02.111.570.120'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D05.500.562.374', 'D08.811.600.250.687', 'D08.811.682.285', 'D12.776.157.530.450.250.875.304', 'D12.776.543.277.687', 'D12.776.543.585.450.250.875.484'], ['A11.284.430.214.190.875.564.627.6... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantitative tools for addressing hospital readmissions. | BACKGROUND: Increased interest in health care cost containment is focusing attention on reduction of hospital readmissions. Major payors have already developed financial penalties for providers that generate excess readmissions. This subject has benefitted from the development of resources such as the Potentially Preve... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Electronic Health Records', 'Health Care Costs', 'Hospitalization', 'Humans', 'Inpatients', 'Length of Stay', 'Middle Aged', 'Patient Discharge', 'Patient Readmission', 'Quality of Health Care', 'Time Factors', 'Young Adult'] | 23,121,730 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['N03.219.151.400', 'N05.300.375'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Oswestry Disability Index: Is Telephone Administration Valid? | Background: The Oswestry Disability Index (ODI) is among the most widely used patient reported outcome measures for the assessment of spinal conditions. Traditionally, the ODI has been administered in outpatient clinics on a face-to-face basis, which can be expensive and time consuming. Furthermore, the percentage of p... | ['Adult', 'Back Pain', 'Disability Evaluation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Reproducibility of Results', 'Spinal Diseases', 'Surveys and Questionnaires', 'Telephone'] | 32,577,114 | [['M01.060.116'], ['C23.888.592.612.107'], ['E01.370.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['C05.116.900'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['L01.178.847.698']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Evidence for nucleosome depletion at active regulatory regions genome-wide. | The identification of nuclease-hypersensitive sites in an active globin gene and in the 5' regions of fruit fly heat shock genes first suggested that chromatin changes accompany gene regulation in vivo. Here we present evidence that the basic repeating units of eukaryotic chromatin, nucleosomes, are depleted from activ... | ['Genes, Fungal', 'Histones', 'Nucleosomes', 'Regulatory Sequences, Nucleic Acid', 'Saccharomyces cerevisiae', 'Transcription, Genetic'] | 15,247,917 | [['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.500'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['A11.284.430.106.279.345.190.160.180.625', 'D12.776.664.224.550', 'G05.360.160.180.625'], ['G02.111.570.080.689', 'G05.360.080.689'], ['B01.300.107.795.785.800', 'B... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Does a fracture at one site predict later fractures at other sites? A British cohort study. | The extent to which a fracture at one skeletal site predicts further fractures at other sites remains uncertain. We addressed this issue using information from the UK General Practice Research Database, which contains the medical records of general practitioners; our study population consisted of all patients aged 20 y... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cohort Studies', 'Confidence Intervals', 'Female', 'Fractures, Bone', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Osteoporosis', 'Patient Selection', 'Risk Factors', 'Sex Factors', 'United Kingdom'] | 12,181,620 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Dietary fat saturation affects hepatocyte insulin binding and glucose metabolism in BHE rats. | The influence of feeding 6% hydrogenated coconut oil, corn oil or menhaden oil on hepatocyte insulin binding, receptor number and glucose use was studied. Hepatocytes isolated from rats fed menhaden oil had a significantly greater affinity for insulin than hepatocytes from rats fed hydrogenated coconut oil. Glucose use... | ['Adenosine Triphosphate', 'Animals', 'Carbon Dioxide', 'Cell Survival', 'Coconut Oil', 'Cocos', 'Corn Oil', 'Dietary Fats', 'Fish Oils', 'Glucose', 'Insulin', 'Liver', 'Male', 'Plant Oils', 'Rats', 'Rats, Inbred Strains', 'Receptor, Insulin'] | 1,941,190 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['G04.346'], ['D10.627.700.186'], ['B01.650.940.800.575.912.250.093.211'], ['D10.212.302.380.370', 'D10.212.507.340', 'D10.627.700.240', 'D20.215.784.750.240', 'G07.203.300.375... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Vascularized collagen-glycosaminoglycan matrix provides a dermal substrate and improves take of cultured epithelial autografts. | Cultured epithelial autografts are an important adjunct in treating severely burned patients, greatly expanding the epidermis using a small donor site. Problems with cultured epithelial autografts include the time delay to culture cells to confluence and variable take on full-thickness wounds. Dermal allografts have be... | ['Animals', 'Collagen', 'Culture Techniques', 'Epithelium', 'Female', 'Glycosaminoglycans', 'Graft Survival', 'Neovascularization, Physiologic', 'Skin Transplantation', 'Surgical Flaps', 'Swine', 'Transplantation, Autologous'] | 9,703,079 | [['B01.050'], ['D05.750.078.280', 'D12.776.860.300.250'], ['E05.481.500'], ['A10.272'], ['D09.698.373'], ['G12.875.545.340'], ['G09.330.630'], ['E02.095.147.725.700', 'E04.680.275.850', 'E04.936.580.700'], ['A10.850.710', 'E07.862.710'], ['B01.050.150.900.649.313.500.880'], ['E04.936.664']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hepatitis C infection in childhood. | Hepatitis C infection in children has a different course than in adults, with higher rates of spontaneous clearance. Prenatal (vertical) transmission is the most common route of transmission in childhood. Only a high maternal viral load and HIV co-infection have been proven to increase the risk of infection in the offs... | ['Antiviral Agents', 'Biopsy', 'Child', 'Female', 'Hepatitis C', 'Hepatitis C, Chronic', 'Humans', 'Interferon alpha-2', 'Interferon-alpha', 'Interferons', 'Liver', 'Mass Screening', 'Polyethylene Glycols', 'Pregnancy', 'Recombinant Proteins', 'Ribavirin'] | 22,521,559 | [['D27.505.954.122.388'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['M01.060.406'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06.552.380.705.440'], ['C01.221.250.750.120', 'C01.925.440.440.120', '... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Clinical information systems--developing a systematic planning process. | CHW is a large and diverse hospital system that developed a systematic planning process to define, prioritize, and assess the current status of those functionalities needed by caregivers to assist them in providing optimal care. In order to develop a durable consensus, a bottom-up approach was used. The details of the ... | ['Benchmarking', 'California', 'Catholicism', 'Decision Making, Organizational', 'Decision Support Systems, Clinical', 'Documentation', 'Group Processes', 'Hospital Information Systems', 'Hospital Planning', 'Hospitals, Religious', 'Humans', 'Investments', 'Medical Staff, Hospital', 'Multi-Institutional Systems', 'Orga... | 11,189,798 | [['N04.452.500.150', 'N04.761.685.150', 'N04.761.700.150', 'N05.700.150', 'N05.715.360.650.150'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['K01.844.188.250'], ['N04.452.190'], ['L01.313.500.750.300.190'], ['L01.453.245'], ['F01.829.316'], ['N04.452.442.452.452', 'N04.452.515.360'], ['N03.349.650.250.200... | ['Health Care [N]', 'Geographicals [Z]', 'Humanities [K]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
A pilot open label study of Cystoprotek in interstitial cystitis. | Interstitial cystitis (IC) is a disorder of the urinary bladder characterized by urgency, frequency, nocturia and suprapubic pain. IC occurs primarily in women and symptoms are exacerbated by stress, ovulatory hormones and certain foods. IC pathogenesis is unknown, but the most consistent findings involve some dysfunct... | ['Adult', 'Chondroitin Sulfates', 'Cystitis, Interstitial', 'Dietary Supplements', 'Drug Combinations', 'Female', 'Glycosaminoglycans', 'Humans', 'Hyaluronic Acid', 'Pilot Projects', 'Urinary Bladder'] | 15,698,523 | [['M01.060.116'], ['D09.698.373.200.300'], ['C12.777.829.495.500', 'C13.351.968.829.495.500'], ['G07.203.300.456', 'J02.500.456'], ['D26.310'], ['D09.698.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.698.373.475'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['A05.8... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
A woman-led approach to improving postnatal care. | As a large NHS teaching trust we see 6,000 women a year who birth with us. Newly appointed as a modern matron, I noted that poor experience on our postnatal ward has always been a key issue in the complaints we receive and from the feedback that our women give to us. The ImPosE (improving postnatal experience) project ... | ['Female', 'Humans', 'Organizational Innovation', 'Patient Care Team', 'Patient Satisfaction', 'Postnatal Care', 'Pregnancy', 'Program Evaluation', 'State Medicine', 'Total Quality Management', 'United Kingdom', "Women's Health", 'Women, Working'] | 25,109,071 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.610'], ['N04.590.715'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', 'N05.300.150.800.625', 'N05.715.360.600'], ['E02.760.703.500', 'N02.421.143.620.550.500', 'N02.421.585.703.500'], ['G08.686.784.769'], ['E05.337.820', 'N04.761.685', 'N05... | ['Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Structural Fat Grafting to Improve Outcomes of Vocal Folds' Fat Augmentation: Long-term Results. | Objective Evaluating the long-term outcomes of vocal fold structural fat grafting. Study Design Case series with chart review. Setting University hospital. Subjects and Methods Seventy-nine dysphonic patients (16-82 years; 55 with unilateral laryngeal paralysis and 24 with vocal fold scarring) underwent vocal fold fat ... | ['Adipose Tissue', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Disability Evaluation', 'Dysphonia', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Tomography, X-Ray Computed', 'Treatment Outcome', 'Video Recording', 'Vocal Cords', 'Voice Quality'] | 29,160,142 | [['A10.165.114'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.400'], ['C08.360.940.325', 'C09.400.940.325', 'C10.597.975.325', 'C23.888.592.979.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E01.370.350.350.810', 'E01... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Personality and attitudes as predictors of risky driving among older drivers. | Although there are several studies on the effects of personality and attitudes on risky driving among young drivers, related research in older drivers is scarce. The present study assessed a model of personality-attitudes-risky driving in a large sample of active older drivers. A cross-sectional design was used, and st... | ['Accidents, Traffic', 'Aged', 'Attitude', 'Automobile Driving', 'Cross-Sectional Studies', 'Female', 'Humans', 'Italy', 'Male', 'Middle Aged', 'Models, Theoretical', 'Personality', 'Personality Inventory', 'Risk-Taking', 'Safety'] | 25,108,900 | [['N06.850.135.392'], ['M01.060.116.100'], ['F01.100'], ['I03.125'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['M01.060.116.630'], ['E05.599'], ['F01.752'], ['F04.711.647.513'], ['F01.145.722'], ['N06.850.135.060.075... | ['Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effect of antenatal glucocorticoids on clinical closure of the ductus arteriosus. | The incidence of clinically detectable patient ductus arteriosus (PDA) in a group of preterm infants whose birth weights were less than 2,000 g was compared with that of a similar group of infants whose mothers received antenatal glucocorticoids. A PDA was diagnosed on the basis of a typical heart murmur, increased pre... | ['Ductus Arteriosus, Patent', 'Female', 'Glucocorticoids', 'Humans', 'Infant, Newborn', 'Infant, Premature, Diseases', 'Male', 'Obstetric Labor, Premature', 'Pregnancy'] | 6,829,513 | [['C14.240.400.340', 'C14.280.400.340', 'C16.131.240.400.340'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C16.614.521'], ['C13.703.420.491'], ['G08.686.784.769']] | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Muscle and species reactivity of mouse monoclonal antibodies to human eye muscle membrane antigens. | We studied the tissue and species reactivity of mouse monoclonal antibodies (MCAB) produced by immunizing mice with a 100,000g ultracentrifuged preparation of human eye muscle (HEM) membranes. Twenty-three MCABs, 20 of which reacted in an enzyme-linked immunosorbent assay (ELISA) with HEM membrane, 2 with human thyroid... | ['Abdominal Muscles', 'Animals', 'Antibodies, Monoclonal', 'Antibody Specificity', 'Blotting, Western', 'Brain', 'Breast', 'Complement Pathway, Classical', 'Cross Reactions', 'Electrophoresis, Polyacrylamide Gel', 'Enzyme-Linked Immunosorbent Assay', 'Eye', 'Humans', 'In Vitro Techniques', 'Lung', 'Membrane Proteins', ... | 1,826,865 | [['A02.633.567.050'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G12.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A08.186.211'], ['A01.236'], ['G12.274.698'], ['G12.122.281'], ['E05.196.40... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hematopoietic growth factors and human acute leukemia. | The study of myelopoietic maturation arrest in acute myeloblastic leukemia (AML) has been eased by availability of the human recombinant hemopoietic growth factors, macrophage colony stimulating factor (M-CSF), granulocyte-(G-CSF), granulocyte-macrophage-(GM-CSF) and multilineage stimulating factor (IL-3). Nonphysiolog... | ['Cell Division', 'Colony-Stimulating Factors', 'Granulocytes', 'Hematopoiesis', 'Humans', 'Interleukin-3', 'Leukemia, Myeloid, Acute', 'Macrophages'] | 3,264,416 | [['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D12.644.276.374.410.240', 'D12.776.395.240', 'D12.776.467.374.410.240', 'D23.529.374.410.240'], ['A11.118.637.415', 'A11.148.350', 'A11.627.340', 'A15.145.229.637.415', 'A15.378.316.340', 'A15.382.490.315'], ['G04.152.825', 'G09.188.343'], ['B... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Retrospective analysis of poisoning cases admitted to the emergency medicine. | BACKGROUND: We aimed herein to assess demographic, etiological, and clinical characteristics of patients presenting to our hospital's emergency department with acute poisoning.METHOD: This study included a total of 509 (0.27%) patients diagnosed with poisoning at our emergency department within a 3-year period. This wa... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Analgesics', 'Antidepressive Agents', 'Demography', 'Emergency Service, Hospital', 'Female', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Poisoning', 'Psychotropic Drugs', 'Retrospective Studies', 'Sex Distribution', 'Suicide, Attempted', 'Young Adult'] | 25,644,801 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['D27.505.954.427.700.122'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
What happened to total parenteral nutrition? The disappearance of its use in a trauma intensive care unit. | BACKGROUND: Total parenteral nutrition (TPN) is associated with known costs, including the use of invasive procedures, which may be necessary to optimize care. Our purpose was to document TPN use in trauma patients over time as well as concurrent changes in TPN-associated complications.METHODS: Retrospective analysis o... | ['Female', 'Humans', 'Injury Severity Score', 'Intensive Care Units', 'Length of Stay', 'Logistic Models', 'Male', 'Middle Aged', 'Parenteral Nutrition, Total', 'Registries', 'Retrospective Studies', 'Risk Factors', 'Trauma Centers', 'Wounds and Injuries'] | 18,212,641 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.940.968.875.500', 'E05.944.600', 'N04.452.859.564.800.500', 'N05.715.360.300.715.500.800.400'], ['N02.278.388.493'], ['E02.760.400.480', 'N02.421.585.400.480'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Glucose metabolic dysfunction in subjects with a clinical dementia rating of 0.5. | OBJECTIVE: To investigate the cerebral glucose metabolism of subjects who had a Clinical Dementia Rating (CDR) of 0.5, we studied 40 subjects whose CDR was 0.5 and 40 age-matched healthy subjects.METHODS: Cerebral glucose image of each subject was obtained by [18F]-2-fluoro-deoxy-D-glucose (FDG) positron emission tomog... | ['Aged', 'Dementia', 'Female', 'Glucose Metabolism Disorders', 'Humans', 'Male', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Tomography, Emission-Computed'] | 14,568,131 | [['M01.060.116.100'], ['C10.228.140.380', 'F03.615.400'], ['C18.452.394'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.711.513.653'], ['E01.370.350.350.800', 'E01.370.350.600.350.800', 'E01.370.350.710.800', 'E01.370.350.825.800', 'E01.370.384.730.800']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae. | We quantified the growth behavior of all available single gene deletion strains of budding yeast under ethanol stress. Genome-wide analyses enabled the extraction of the genes and determination of the functional categories required for growth under this condition. Statistical analyses revealed that the growth of 446 de... | ['Adaptation, Physiological', 'Antifungal Agents', 'Ethanol', 'Gene Deletion', 'Gene Expression Regulation, Fungal', 'Genes, Fungal', 'Osmotic Pressure', 'Saccharomyces cerevisiae'] | 19,054,128 | [['G07.025', 'G16.012.500'], ['D27.505.954.122.136'], ['D02.033.375'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.308.330'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.500'], ['G01.374.715.578', 'G02.640.249', 'G02.723.661'], ['B01.300.107.795.785.800', 'B01.300.930.705.655']... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The association between fatigue and pain symptoms and decreased physical activity after cancer. | PURPOSE: Patients with cancer frequently experience symptoms such as fatigue and pain that can influence their ability to maintain their usual physical activity (PA). This study aimed to evaluate whether symptoms of fatigue and pain are associated with decreased PA among patients with cancer.METHODS: We recruited patie... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cross-Sectional Studies', 'Exercise', 'Fatigue', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Pain', 'Surveys and Questionnaires', 'Young Adult'] | 29,675,547 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G11.427.410.698.277', 'I03.350'], ['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['C23.888.592.612', 'F02.830.816.444', 'G11.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Feasibility and Safety of an Operative Tool for Anterior Chronic Exertional Compartment Syndrome Treatment. | BACKGROUND: Operative management of chronic exertional compartment syndrome of the tibialis anterior muscle compartment (ant-CECS) usually involves the use of a fasciotome. Collateral tissue damage such as hematoma and nerve damage may occur during the procedure. The current report assessed the feasibility and safety o... | ['Adolescent', 'Adult', 'Compartment Syndromes', 'Equipment Design', 'Fasciotomy', 'Feasibility Studies', 'Female', 'Humans', 'Lower Extremity', 'Male', 'Middle Aged', 'Operative Time', 'Patient Safety', 'Patient Satisfaction', 'Physical Exertion', 'Return to Sport', 'Surgical Instruments', 'Young Adult'] | 26,219,908 | [['M01.060.057'], ['M01.060.116'], ['C05.651.180', 'C14.907.303'], ['E05.320'], ['E04.321'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610'], ['M01.060.116.630'], ['E04.614.374.500', 'N02.421.585.753.374.500'], ['N06.850.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa. | The Population Council's microbicide gel MZC (also known as PC-1005) containing MIV-150 and zinc acetate dihydrate (ZA) in carrageenan (CG) has shown promise as a broad-spectrum microbicide against HIV, herpes simplex virus (HSV), and human papillomavirus. Previous data show antiviral activity against these viruses in ... | ['Animals', 'Antiviral Agents', 'Female', 'Gels', 'Herpesvirus 2, Human', 'Macaca', 'Microbial Sensitivity Tests', 'Models, Theoretical', 'Mucous Membrane', 'Organ Culture Techniques', 'Pyridines', 'RNA-Directed DNA Polymerase', 'Rectum', 'Simian Immunodeficiency Virus', 'Urea', 'Vagina'] | 27,552,154 | [['B01.050'], ['D27.505.954.122.388'], ['D20.280.320', 'D26.255.165.320'], ['B04.280.382.100.750.440'], ['B01.050.150.900.649.313.988.400.112.199.120.510'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['E05.599'], ['A10.615.550'], ['E05.481.500.484'], ['D03.383.725'], ['D08.811.913.696.445.308.300.75... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tactual, visual, and cross-modal transfer of texture in 5- and 8-year-old children. | Children's tactual, visual, and cross-modal transfer abilities for texture were investigated in a delayed matching-to-sample paradigm. Transfer performance from vision to touch was found to increase between 5 and 8 years of age, whereas transfer performance from touch to vision did not vary with age and matched touch-t... | ['Analysis of Variance', 'Child', 'Child Development', 'Child, Preschool', 'Discrimination Learning', 'Female', 'Humans', 'Male', 'Pattern Recognition, Visual', 'Psychology, Child', 'Surface Properties', 'Touch', 'Transfer, Psychology'] | 17,624,118 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['M01.060.406.448'], ['F02.463.425.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['F04.096.628.193'], ['G02.860'], ['F02.830.816.850', 'G11.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Alternative nuclear transport for cellular protein quality control. | Herpesvirus capsids traverse the nuclear envelope (NE) by utilizing an unusual export pathway termed nuclear egress. In this process, the viral capsid is delivered into the perinuclear space (PNS), producing a vesicular intermediate after fission. After fusion with the outer nuclear membrane (ONM), the naked capsid is ... | ['Active Transport, Cell Nucleus', 'Animals', 'Cell Nucleus', 'Cell Nucleus Shape', 'Humans', 'Proteins'] | 22,858,153 | [['G03.143.310.100', 'G03.143.700.100'], ['B01.050'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['G04.655.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of dietary iron overload on glutathione peroxidase knockout mice. | Excess iron (Fe) intake has been associated with an increased risk of cardiovascular disease in humans, presumably the result of increased oxidative stress. Previous work by us has shown that feeding a high-Fe diet to selenium (Se)-deficient weanling mice for 4 wk resulted in elevated plasma cholesterol and triglycerid... | ['Animals', 'Cholesterol', 'Diet', 'Glutathione Peroxidase', 'Iron', 'Liver', 'Mice', 'Mice, Knockout', 'Spectrophotometry, Atomic', 'Thiobarbituric Acid Reactive Substances', 'Triglycerides'] | 12,117,267 | [['B01.050'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['G07.203.650.240'], ['D08.811.682.732.500'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
TIN2 mediates functions of TRF2 at human telomeres. | Telomeres are protective structures at chromosome ends and are crucial for genomic stability. Mammalian TRF1 and TRF2 bind the double-stranded telomeric repeat sequence and in turn are bound by TIN2, TANK1, TANK2, and hRAP1. TRF1 is a negative regulator of telomere length in telomerase-positive cells, whereas TRF2 is i... | ['Cell Line', 'Humans', 'Protein Binding', 'Recombinant Proteins', 'Telomerase', 'Telomere', 'Telomere-Binding Proteins', 'Telomeric Repeat Binding Protein 1', 'Telomeric Repeat Binding Protein 2'] | 15,292,264 | [['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.679', 'G03.808'], ['D12.776.828'], ['D08.811.913.696.445.308.300.750.750', 'D12.776.157.687.613', 'D12.776.157.725.500.921', 'D12.776.660.720.613', 'D12.776.664.962.500.921'], ['A11.284.430.106.279.345.190.160.845', 'G05.360.160.845'], ['D12.7... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Trends in gynecologic cancer among elderly women in Denmark, 1980-2012. | BACKGROUND: The aim of this analysis was to describe trends in incidence, mortality, prevalence, and survival in Danish women with gynecologic cancer from 1980-2012 comparing women aged 70 years or more with younger women.MATERIAL AND METHODS: Gynecologic cancers included were ICD-10 codes C53 (cancer of the cervix ute... | ['Age Distribution', 'Aged', 'Aged, 80 and over', 'Combined Modality Therapy', 'Denmark', 'Early Detection of Cancer', 'Female', 'Genital Neoplasms, Female', 'Humans', 'Incidence', 'Mass Screening', 'Neoplasm Staging', 'Ovarian Neoplasms', 'Patient Care Team', 'Prevalence', 'Prognosis', 'Registries', 'Risk Factors', 'S... | 26,784,001 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.186'], ['Z01.542.816.124'], ['E01.390.500'], ['C04.588.945.418', 'C13.351.937.418'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.37... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Modeling reveals that dynamic regulation of c-FLIP levels determines cell-to-cell distribution of CD95-mediated apoptosis. | The expression levels of caspase-8 inhibitory c-FLIP proteins play an important role in regulating death receptor-mediated apoptosis, as their concentration at the moment when the death-inducing signaling complex (DISC) is formed determines the outcome of the DISC signal. Experimental studies have shown that c-FLIP pro... | ['Apoptosis', 'CASP8 and FADD-Like Apoptosis Regulating Protein', 'Cell Communication', 'Cell Line, Tumor', 'Humans', 'Models, Biological', 'Monte Carlo Method', 'Signal Transduction', 'fas Receptor'] | 21,324,892 | [['G04.146.954.035'], ['D12.644.360.024.285.024', 'D12.644.360.024.500.024', 'D12.644.360.075.421.024', 'D12.776.157.057.018.024', 'D12.776.476.075.421.024'], ['G04.085'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['E05.318.740.525', 'L01.906.394.422', 'N0... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Naphthalene metabolism and growth inhibition by naphthalene in Polaromonas naphthalenivorans strain CJ2. | This study was designed to characterize naphthalene metabolism in Polaromonas naphthalenivorans CJ2. Comparisons were completed using two archetypal naphthalene-degrading bacteria: Pseudomonas putida NCIB 9816-4 and Ralstonia sp. strain U2, representative of the catechol and gentisate pathways, respectively. Strain CJ2... | ['Chromatography, High Pressure Liquid', 'Comamonadaceae', 'Culture Media', 'Dioxygenases', 'Gas Chromatography-Mass Spectrometry', 'Gentisates', 'Mutation', 'Naphthalenes', 'Naphthoquinones', 'Oxygen Consumption'] | 17,975,081 | [['E05.196.181.400.300'], ['B03.440.400.425.293', 'B03.660.075.090.766'], ['D27.720.470.305', 'E07.206'], ['D08.811.682.690.416'], ['E05.196.181.349.500', 'E05.196.566.500'], ['D02.241.223.100.300.595.405', 'D02.241.511.390.595.405', 'D02.455.426.559.389.127.281.595.405', 'D02.455.426.559.389.657.410.595.405'], ['G05.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The 5'-proximal hairpin of turnip yellow mosaic virus RNA: its role in translation and encapsidation. | The RNA genome of turnip yellow mosaic virus (TYMV) consists of more than 6,000 nucleotides. During a study of the roles of the two hairpins located in its 90-nucleotide 5' untranslated region, it was observed that stabilization of the 5'-proximal hairpin leads to a delay in the development of symptoms on plants. This ... | ['Base Sequence', 'Capsid', 'Molecular Sequence Data', 'Nucleic Acid Conformation', 'Protein Biosynthesis', 'Transfection', 'Tymovirus'] | 12,805,444 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A21.249.500.250'], ['L01.453.245.667'], ['G02.111.570.820.486', 'G05.360.580'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['E05.393.350.810', 'G05.728.860'], ['B04.715.464.750', 'B04.715.850.860', 'B04.820.578.984.850']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The common variant N372H in BRCA2 gene may be associated with idiopathic male infertility with azoospermia or severe oligozoospermia. | OBJECTIVE: To explore the possible association between the common single nucleotide polymorphism N372H in human breast cancer susceptibility gene 2 (BRCA2) and the idiopathic male infertility with azoospermia or severe oligozoospermia.STUDY DESIGN: The study included 240 infertile patients with idiopathic azoospermia o... | ['Chromatography, High Pressure Liquid', 'Gene Frequency', 'Genes, BRCA2', 'Humans', 'Infertility, Male', 'Male', 'Oligospermia', 'Polymorphism, Single Nucleotide'] | 16,257,105 | [['E05.196.181.400.300'], ['G05.330'], ['G05.360.340.024.340.375.249.105', 'G05.360.340.024.340.415.400.105'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['C12.294.365.700.508'], ['G05.365.795.598']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dental caries in HIV-infected children versus household peers: two-year findings. | PURPOSE: This report will present a two-year comparison of the incidence and baseline prevalence of dental caries found in both the primary and permanent dentition among a cohort of HIV-infected children as compared to household peer control subjects who were not HIV-infected.METHODS: The subjects in this report were f... | ['Adolescent', 'Analysis of Variance', 'Case-Control Studies', 'Chi-Square Distribution', 'Child', 'Child, Preschool', 'DMF Index', 'Dental Caries', 'Dentition, Permanent', 'Female', 'HIV Infections', 'Humans', 'Incidence', 'Infant', 'Longitudinal Studies', 'Male', 'New Jersey', 'Peer Group', 'Prevalence', 'Tooth Erupt... | 10,846,731 | [['M01.060.057'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.308.980.438.30... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A study on the sizes and concentrations of gold nanoparticles by spectra of absorption, resonance Rayleigh scattering and resonance non-linear scattering. | Liquid phase gold nanoparticles with different diameters and colors can be prepared using sodium citrate reduction method by controlling the amounts of sodium citrate. The mean diameters of gold nanoparticles are measured by transmission electron microscope (TEM). Gold nanoparticles with different sizes have specific a... | ['Color', 'Gold', 'Microscopy, Electron, Transmission', 'Nanostructures', 'Spectrum Analysis'] | 16,165,025 | [['G01.590.540.199'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['E01.370.350.515.402.580', 'E05.595.402.580'], ['J01.637.512'], ['E05.196.867']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Inostamycin, an inhibitor of P-glycoprotein function, interacts specifically with phosphatidylethanolamine. | The mechanism of inostamycin action was further studied. When multidrug-resistant KB-C4 cells were preincubated with inostamycin for 30 min, the accumulation of [3H]vinblastine was increased for as long as 48 h thereafter. Inostamycin inhibited azidopine binding to P-glycoprotein, even after KB plasma membranes had bee... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Anti-Bacterial Agents', 'Antineoplastic Agents, Phytogenic', 'Azides', 'Binding, Competitive', 'Cell Membrane', 'Dihydropyridines', 'Furans', 'Humans', 'KB Cells', 'Phosphatidylethanolamines', 'Sensitivity and Specificity', 'Tritium', 'Vinblastine'] | 7,591,966 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['D27.505.954.122.085'], ['D27.505.954.248.179'], ['D01.625.100', 'D02.159'], ['E05.196.080', 'G02.111.084'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of tamoxifen on potential doubling time of human breast cancer cell line determined by image cytometry of double fluorescent BrdU and DNA labeling. | Tamoxifen is extensively used for the treatment of human breast cancer. However, the mechanisms by which antiestrogens regulate the growth of estrogen receptor positive tumors have not been totally defined. A new methodology, using automated image analysis BIOCOM 500, was developed for determining potential doubling ti... | ['Breast Neoplasms', 'Bromodeoxyuridine', 'Cell Cycle', 'Cell Division', 'DNA, Neoplasm', 'Flow Cytometry', 'Fluorescent Antibody Technique', 'Humans', 'Image Processing, Computer-Assisted', 'Staining and Labeling', 'Tamoxifen', 'Tumor Cells, Cultured'] | 7,531,416 | [['C04.588.180', 'C17.800.090.500'], ['D03.383.742.680.852.300.150', 'D13.570.230.430.196', 'D13.570.685.852.300.150'], ['G04.144'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D13.444.308.425'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.2... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Is bad living better than good death? Impact of demographic and cultural factors on health state preference. | PURPOSE: The aim of this study was to examine the impact of demographic and cultural factors on health preferences among Chinese general population.METHODS: The Chinese EQ-5D-5L valuation study was conducted between December 2012 and January 2013. A total of 1296 participants were recruited from the general public at B... | ['Adolescent', 'Adult', 'Beijing', 'Buddhism', 'China', 'Choice Behavior', 'Female', 'Health Status', 'Humans', 'Linear Models', 'Logistic Models', 'Male', 'Middle Aged', 'Patient Preference', 'Quality of Life', 'Quality-Adjusted Life Years', 'Religious Philosophies', 'Surveys and Questionnaires', 'Young Adult'] | 26,346,987 | [['M01.060.057'], ['M01.060.116'], ['Z01.252.474.164.225', 'Z01.433.114'], ['K01.844.117'], ['Z01.252.474.164'], ['F02.463.785.373.346'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360... | ['Named Groups [M]', 'Geographicals [Z]', 'Humanities [K]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death. | Expression of the bcl-2 gene has been shown to effectively confer resistance to programmed cell death under a variety of circumstances. However, despite a wealth of literature describing this phenomenon, very little is known about the mechanism of resistance. In the experiments described here, we show that bcl-2 gene e... | ['Animals', 'Apoptosis', 'Bromodeoxyuridine', 'Cell Cycle', 'Cell Division', 'Cells, Cultured', 'Crosses, Genetic', 'DNA', 'Female', 'Gene Expression', 'Homeostasis', 'Humans', 'Kinetics', 'Lymph Nodes', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-bcl-... | 8,642,331 | [['B01.050'], ['G04.146.954.035'], ['D03.383.742.680.852.300.150', 'D13.570.230.430.196', 'D13.570.685.852.300.150'], ['G04.144'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['E05.393.281'], ['D13.444.308'], ['G05.297'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Incidence of pediatric inflammatory bowel disease in Saudi Arabia: a multicenter national study. | BACKGROUND: Pediatric inflammatory bowel disease (IBD) is increasingly recognized in developing countries; however, the incidence and trend over time have not been reported.METHODS: This retrospective study included children diagnosed with IBD in gastroenterology centers in the Kingdom of Saudi Arabia between 2003 and ... | ['Adolescent', 'Child', 'Child, Preschool', 'Colitis, Ulcerative', 'Crohn Disease', 'Databases, Factual', 'Female', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Male', 'Poisson Distribution', 'Retrospective Studies', 'Risk Factors', 'Saudi Arabia'] | 24,788,219 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985... | ['Named Groups [M]', 'Diseases [C]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Mercuric salt-catalyzed removal of unsaturated glucuronic acid from chondroitinase-treated proteochondroitin sulfate. | Aggrecan (PG) was isolated from Swarm rat chondrosarcoma and the chondroitin 4-sulfate removed with chondroitinase ABC (ABC) or ACII (AC), leaving a 4-deoxy-beta-d-gluc-4-enuronosyl (DeltaGlcA) residue on the nonreducing terminus of the attached chondroitin sulfate chains. Mercuric acetate (as low as 5 mm) removed the ... | ['Aggrecans', 'Animals', 'Antibodies, Monoclonal', 'Chondroitin Sulfate Proteoglycans', 'Chondroitinases and Chondroitin Lyases', 'Extracellular Matrix Proteins', 'Glucuronates', 'Glucuronic Acid', 'Hydrogen-Ion Concentration', 'Lectins, C-Type', 'Mercury', 'Proteoglycans', 'Rats'] | 9,028,874 | [['D09.698.735.200.500', 'D12.776.395.650.750.687.100', 'D12.776.503.280.437.100', 'D12.776.860.300.140'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D09.698.735.200', 'D12.776.395.650.750'], ['D08.811.277.352.827.180', 'D08.811.520.241.700.350'], ['D12... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Auto-antibodies against oxidized LDL as a marker of coronary artery disease in patients with familial hypercholesterolaemia. | Auto-antibodies to oxidized low-density lipoprotein (ox-LDL) are thought to play a pivotal role in the pathogenesis of atherosclerosis. This study investigates the value of auto-antibodies to ox-LDL as a predictive marker of atherosclerosis in patients with both homozygous and heterozygous familial hypercholesterolaemi... | ['Adult', 'Arteriosclerosis', 'Autoantibodies', 'Biomarkers', 'Carotid Arteries', 'Cholesterol, LDL', 'Coronary Disease', 'Female', 'Heterozygote', 'Homozygote', 'Humans', 'Hyperlipoproteinemia Type II', 'Lipoproteins, LDL', 'Male', 'Middle Aged', 'Risk Factors'] | 10,735,360 | [['M01.060.116'], ['C14.907.137.126'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D23.101'], ['A07.015.114.186'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'], ['C14.280.647.250', 'C14.907.585.250'], ['G05.380.383'... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Designing Pd-on-Au bimetallic nanoparticle catalysts for trichloroethene hydrodechlorination. | Alumina-supported palladium (Pd) catalysts have previously been shown to hydrodechlorinate trichloroethene (TCE) and other chlorinated compounds in water, at room temperature, and in the presence of hydrogen. The feasibility of this catalytic technology to remediate groundwater of halogenated compounds can be improved ... | ['Catalysis', 'Chlorine', 'Nanostructures', 'Palladium', 'Silver', 'Soil Pollutants', 'Solvents', 'Trichloroethylene', 'Water Pollutants'] | 15,787,376 | [['G02.130'], ['D01.268.380.150', 'D01.362.225'], ['J01.637.512'], ['D01.268.556.680', 'D01.268.956.718', 'D01.552.544.680'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812'], ['D27.888.284.756'], ['D27.720.844'], ['D02.455.526.439.939'], ['D27.888.284.903']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The mechanism of two-phase motility in the spirochete Leptospira | Many species of bacteria are motile, but their migration mechanisms are considerably diverse. Whatever mechanism is used, being motile allows bacteria to search for more optimal environments for growth, and motility is a crucial virulence factor for pathogenic species. The spirochete Leptospira, having two flagella in ... | ['Bacterial Physiological Phenomena', 'Cell Membrane', 'Leptospiraceae', 'Microscopy, Fluorescence'] | 29,854,948 | [['G06.099'], ['A11.284.149'], ['B03.440.400.425.475', 'B03.851.475'], ['E01.370.350.515.458', 'E05.595.458']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Performance of police first responders in utilizing automated external defibrillation on victims of sudden cardiac arrest. | OBJECTIVE: Rates of resuscitation from cardiac arrest are directly tied to time to defibrillation. To maximize results, the first arriving care provider should be equipped and trained to defibrillate. This would include police in those systems where they serve this function; to date, no training program has been examin... | ['Automation', 'Clinical Competence', 'Documentation', 'Electric Countershock', 'Emergency Treatment', 'Heart Arrest', 'Humans', 'Pennsylvania', 'Police', 'Program Evaluation'] | 9,709,327 | [['J01.897.104'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['L01.453.245'], ['E02.331.350'], ['E02.365'], ['C14.280.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.075.550', 'Z01.107.567.875.350.550', 'Z01.107.567.875.500.550'], ['M01.526.373.750', 'M01.526.760'], ['E05.337.820', 'N0... | ['Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
[Detection of group B streptococcus in the cases died of neonatal pneumonia]. | OBJECTIVE: From the 1970s, group B streptococci (GBS) have been widely recognized as an important pathogen in neonatal infectious disease, and it emerged as the leading cause of neonatal morbidity and mortality in the Western world. However, there are few data on the prevalence of neonatal GBS infections in China. The ... | ['China', 'Humans', 'Infant, Newborn', 'Pneumonia, Staphylococcal', 'Prevalence', 'Retrospective Studies', 'Streptococcus agalactiae'] | 17,274,877 | [['Z01.252.474.164'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C01.150.252.410.868.675', 'C01.150.252.620.620', 'C01.748.610.540.620', 'C08.381.677.540.620', 'C08.730.610.540.620'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.... | ['Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Identification of a rod domain-truncated isoform of nestin, Nes-SÄ₁₀₇₋₂₅₄, in rat dorsal root ganglia. | Nestin, a type VI intermediate filament (IF) protein, is predominantly expressed in neurogenic and myogenic stem cells. We previously identified the first isoform of nestin, Nes-S, in rat DRG neurons. In this study, we report a previously unidentified nestin isoform, Nes-SÄ₁₀₇₋₂₅₄, that is expressed in lower levels in ... | ['Alternative Splicing', 'Animals', 'Apoptosis', 'Caspase 3', 'Cells, Cultured', 'Ganglia, Spinal', 'Humans', 'Nestin', 'Protein Isoforms', 'Protein Structure, Tertiary', 'Rats', 'Transfection'] | 23,994,057 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['B01.050'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A11.251'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Survey of urine from transplant recipients for polyomaviruses JC and BK using the polymerase chain reaction. | Using polymerase chain reaction (PCR), we examined 108 urine specimens from 39 post transplant patients for polyomaviruses JC (JCV) and BK (BKV). Urine sediments were collected and subjected to 30 cycles of amplification. PCR products were resolved by agarose gel electrophoresis, transferred to nylon membranes by South... | ['DNA, Viral', 'Heart Transplantation', 'Humans', 'Liver Transplantation', 'Nucleic Acid Hybridization', 'Organ Transplantation', 'Polymerase Chain Reaction', 'Polyomavirus', 'Tumor Virus Infections'] | 1,649,395 | [['D13.444.308.568'], ['E04.100.376.475', 'E04.928.220.390', 'E04.936.450.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['E05.393.661', 'G02.111.611'], ['E04.936.450'], ['E05.393.620.500'], ['B04.280.210.700.615', 'B04.613.204.670.6... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Influence of HLA and KIR Genes on Malignant Melanoma Development and Progression. | Many studies have described the role of killer immunoglobulin-like receptors (KIRs) and their cognate human leukocyte antigen (HLA) class I ligands in the immune protection against melanoma, but the effect of these markers on intra-individual variations in tumor development and progression has remained less clear. We p... | ['Adult', 'Aged', 'Aged, 80 and over', 'Alleles', 'Amino Acid Motifs', 'Disease Progression', 'Female', 'Gene Expression Regulation, Neoplastic', 'Genetic Predisposition to Disease', 'Genotype', 'HLA Antigens', 'HLA-A3 Antigen', 'HLA-C Antigens', 'Histocompatibility Antigens Class I', 'Humans', 'Killer Cells, Natural',... | 28,083,606 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G05.360.340.024.340.030'], ['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['C23.550.291.656'], ['G05.308.370'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['D23.050.301.500.450', 'D23.050.705.552.450'], ['D12.776.395.550.489.40... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Using the ecological framework to identify barriers and enablers to implementing Namaste Care in Canada's long-term care system. | BACKGROUND: Higher acuity of care at the time of admission to long-term care (LTC) is resulting in a shorter period to time of death, yet most LTC homes in Canada do not have formalized approaches to palliative care. Namaste Care is a palliative care approach specifically tailored to persons with advanced cognitive imp... | ['Aged', 'Canada', 'Communication Barriers', 'Dementia', 'Focus Groups', 'Health Services for the Aged', 'Humans', 'Interviews as Topic', 'Long-Term Care', 'Palliative Care'] | 28,754,046 | [['M01.060.116.100'], ['Z01.107.567.176'], ['L01.143.230'], ['C10.228.140.380', 'F03.615.400'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['N02.421.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['E02... | ['Named Groups [M]', 'Geographicals [Z]', 'Information Science [L]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Relationship between the high-energy phosphate content and various left ventricular functional parameters of the normal and hypertrophied heart after global ischemia and reperfusion. | Using an isolated rat heart preparation (Langendorff perfusion, perfusion pressure 100 cm H2O) the correlation between the high-energy phosphate content and various left ventricular (lv) functional parameters of the hypertrophied heart (spontaneous hypertensive rats lv/body weight ratio 3.6 +/- 0.5 x 10(-3) was determi... | ['Adenosine Diphosphate', 'Adenosine Triphosphate', 'Animals', 'Cardiomyopathy, Hypertrophic', 'Coronary Circulation', 'Energy Metabolism', 'Heart Arrest, Induced', 'Myocardial Contraction', 'Myocardium', 'Rats', 'Rats, Inbred SHR'] | 3,388,406 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['C14.280.238.100', 'C14.280.484.048.750.070.160'], ['G09.330.100.324'], ['G03.295'], ['E04.100.376.374', 'E04.928.220.360'], ['G09.330.580', 'G11.4... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antigenic conservation of H1N1 swine influenza viruses. | Influenza viruses of the H1N1 subtype have been continually circulating in pigs in the U.S.A. for at least 50 years. To examine the level of antigenic variation in these swine viruses, a panel of 60 monoclonal antibodies (MAbs) to the haemagglutinin (HA) of recent swine isolates was prepared. Evaluation of neutralizati... | ['Animals', 'Antibodies, Monoclonal', 'Antigenic Variation', 'Antigens, Viral', 'Disease Outbreaks', 'Ducks', 'Enzyme-Linked Immunosorbent Assay', 'Hemagglutination Inhibition Tests', 'Hemagglutination Tests', 'Hemagglutinins, Viral', 'Humans', 'Influenza A Virus, H1N1 Subtype', 'Influenza A virus', 'Orthomyxoviridae I... | 2,558,159 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G05.365.073', 'G12.500.249'], ['D23.050.327'], ['N06.850.290'], ['B01.050.150.900.248.050.200', 'B01.050.150.900.248.690.345'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.47... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Relationship between endogenous hormonal content and somatic organogenesis in callus of peach (Prunus persica L. Batsch) cultivars and Prunus persica?Prunus dulcis rootstocks. | The relationship between endogenous hormones content and the induction of somatic peach plant was studied. To induce multiple shoots from callus derived from the base of stem explants of the scion cultivars 'UFO-3', 'Flariba' and 'Alice Bigi', and the peach?almond rootstocks 'Garnem' and 'GF677', propagated plants were... | ['Chromatography, High Pressure Liquid', 'Hybridization, Genetic', 'Mass Spectrometry', 'Morphogenesis', 'Plant Growth Regulators', 'Plant Roots', 'Plant Shoots', 'Prunus'] | 24,709,154 | [['E05.196.181.400.300'], ['E05.820.150.390', 'G05.090.390'], ['E05.196.566'], ['G07.345.500'], ['D27.505.696.377.760'], ['A18.400'], ['A18.024.875'], ['B01.650.940.800.575.912.250.859.937.500.625']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Integrin signaling, free radicals, and tyrosine kinase mediate flow constriction in isolated cerebral arteries. | Isolated, cannulated, and pressurized (100 mmHg) middle cerebral arteries from adult cats were perfused intraluminally at rates from 0 to 4 ml/min with heated and gassed physiological saline solution. An electronic system held pressure constant by changing outflow resistance. The arteries constricted 18.1 +/- 0.95% in ... | ['Animals', 'Blood Flow Velocity', 'Blood Pressure', 'Cats', 'Female', 'In Vitro Techniques', 'Integrins', 'Male', 'Membrane Potentials', 'Middle Cerebral Artery', 'Muscle Contraction', 'NG-Nitroarginine Methyl Ester', 'Protein-Tyrosine Kinases', 'Signal Transduction', 'Stress, Mechanical', 'Superoxide Dismutase', 'Vas... | 10,600,845 | [['B01.050'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.481'], ['D12.776.543.750.705.408'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['A07.015.114.228.550'], ['G11.427.494'], ['D12.125.068.050.525', 'D1... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Measuring the quality of clinical performance with hernia and myocardial infarction patients, controlling for patient risks. | This article describes a method for measuring the performance of clinicians treating patients with unilateral inguinal hernia or myocardial infarction. The scoring was based upon the percentage of occasions when appropriate education was given and acute conditions resolved in accordance with clinical expectations. The ... | ['Clinical Competence', 'Hernia, Inguinal', 'Humans', 'London', 'Myocardial Infarction', 'Outcome and Process Assessment, Health Care', 'Patient Education as Topic', 'Quality of Health Care', 'Recurrence', 'Risk'] | 7,218,893 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['C23.300.707.374.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.433.553', 'Z01.542.363.300.553'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['N04.761.559', 'N05.715.360.575'], ['I02.233.332.500', 'N02.421.726... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Trough levels and concentration time curves of cyclosporine in patients undergoing renal transplantation. | We determined the AUC of cyclosporine (24 hours) nonspecifically by RIA and specifically by HPLC after an oral and an intravenous dose of cyclosporine in 58 patients undergoing renal transplantation. The RIA/HPLC concentration ratio of cyclosporine changed continuously during the first 12 hours after administration. Th... | ['Adult', 'Aged', 'Chromatography, High Pressure Liquid', 'Cyclosporins', 'Female', 'Humans', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Radioimmunoassay', 'Time Factors'] | 3,275,522 | [['M01.060.116'], ['M01.060.116.100'], ['E05.196.181.400.300'], ['D04.345.566.235', 'D12.644.641.235'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.060.116.630'], ['E01.370.384.700', 'E05.478.566.639', 'E05.601.470.639'], ['G01.910.857']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Molecular detection of H. pylori antibiotic-resistant genes and molecular docking analysis. | To explore the mutation characteristics of H. pylori resistance-related genes to antibiotics of clarithromycin (CAM), levofloxacin (LVX) and metronidazole, 23SrRNA, gyrA, gyrB, rdxA, and frxA genes were amplified and sequenced, respectively. Molecular docking study was performed to explore molecular interactions betwee... | ['Anti-Bacterial Agents', 'Bacterial Proteins', 'Clarithromycin', 'DNA, Bacterial', 'Drug Resistance, Bacterial', 'Genes, Bacterial', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Levofloxacin', 'Metronidazole', 'Microbial Sensitivity Tests', 'Mutation'] | 31,914,672 | [['D27.505.954.122.085'], ['D12.776.097'], ['D02.540.576.500.992.100'], ['D13.444.308.212'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['C01.150.252.400.466'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['B0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Poly(ADP-ribose) polymerase triggers the microvascular mechanisms of hepatic ischemia-reperfusion injury. | Activation of poly(ADP-ribose) polymerase (PARP) mediates oxidative stress-induced cell injury. We tested the hypothesis that PARP contributes to ischemia-reperfusion (I/R) damage of the liver by triggering the mechanisms of microcirculatory failure. Leukocyte- and platelet-endothelial cell interactions as well as sinu... | ['Alanine Transaminase', 'Animals', 'Aspartate Aminotransferases', 'Blood Platelets', 'Cell Communication', 'Endothelium, Vascular', 'Female', 'Ischemia', 'Leukocytes', 'Liver', 'Liver Circulation', 'Mice', 'Mice, Inbred Strains', 'Mice, Knockout', 'Microcirculation', 'P-Selectin', 'Poly(ADP-ribose) Polymerases', 'RNA,... | 12,181,167 | [['D08.811.913.477.700.100'], ['B01.050'], ['D08.811.913.477.700.225'], ['A11.118.188', 'A15.145.229.188'], ['G04.085'], ['A07.015.700.500', 'A10.272.491.355'], ['C23.550.513'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['A03.620'], ['G09.330.100.881.552'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.05... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fibroblast sheets co-cultured with endothelial progenitor cells improve cardiac function of infarcted hearts. | We have already confirmed that cell sheet transplantation can improve damaged heart function via continuous cytokine secretion. In this study, we hypothesized that cytokine-secreting cell sheets co-cultured with an endothelial cell source may be more effective for repairing ischemic myocardium. Confluent rat fibroblast... | ['Animals', 'Coculture Techniques', 'Doxorubicin', 'Echocardiography', 'Endothelial Cells', 'Fibroblasts', 'Myocardial Contraction', 'Myocardial Infarction', 'Neovascularization, Physiologic', 'Rats', 'Rats, Nude', 'Stem Cell Transplantation', 'Tissue Engineering'] | 18,836,875 | [['B01.050'], ['E05.481.500.374'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['A11.436.275'], ['A11.329.228'], ['G09.330.580', 'G11.427.494.570'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.5... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Neural mechanisms for coping with acoustically reduced speech. | In spoken language, reductions of word forms occur regularly and need to be accommodated by the listener. Intriguingly, this accommodation is usually achieved without any apparent effort. The neural bases of this cognitive skill are not yet fully understood. We here presented participants with reduced words that were e... | ['Acoustics', 'Adaptation, Psychological', 'Adult', 'Attention', 'Brain', 'Comprehension', 'Electroencephalography', 'Female', 'Humans', 'Male', 'Memory', 'Reaction Time', 'Speech Perception', 'Young Adult'] | 30,822,731 | [['H01.671.031'], ['F01.058'], ['M01.060.116'], ['F02.830.104.214'], ['A08.186.211'], ['F02.463.188.357'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['F02.463.593.071.875', 'G07.888.125.875'... | ['Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
GABA influences the development of the ventromedial nucleus of the hypothalamus. | The region that becomes the ventromedial nucleus of the hypothalamus (VMH) is surrounded by cells and fibers containing immunoreactive gamma-aminobutyric acid (GABA) by embryonic day 13 (E13), several days before the nucleus emerges in Nissl stains. As GABA plays many roles during neural development, we hypothesized th... | ['Animals', 'Brain Chemistry', 'Estrogen Receptor alpha', 'Female', 'Fluorescent Dyes', 'GABA Agonists', 'GABA Antagonists', 'GABA-A Receptor Agonists', 'GABA-A Receptor Antagonists', 'Gene Expression Regulation, Developmental', 'Immunohistochemistry', 'In Vitro Techniques', 'Mice', 'Mice, Inbred C57BL', 'Microscopy, V... | 11,745,664 | [['B01.050'], ['G02.111.150', 'G03.185'], ['D12.776.826.750.350.174'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D27.505.519.625.240.200', 'D27.505.696.577.240.200'], ['D27.505.519.625.240.300', 'D27.505.696.577.240.300'], ['D27.505.519.625.240.200.500', 'D27.505.696.577.240.200.500'], ['D27.505.519.625.240.300... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Effect of total knee arthroplasty implant position on flexion angle before implant-bone impingement. | We generated patient-specific computer models of total knee arthroplasty from 10 patients to compute maximum flexion angle before implant-bone impingement. Motion was simulated for 5 different femoral implant positions and 11 different tibial insert positions at 4 different tibial posterior slopes. In the neutral posit... | ['Aged', 'Aged, 80 and over', 'Arthroplasty, Replacement', 'Arthroplasty, Replacement, Knee', 'Biomechanical Phenomena', 'Bone Malalignment', 'Computer Simulation', 'Female', 'Humans', 'Knee Joint', 'Knee Prosthesis', 'Male', 'Middle Aged', 'Posterior Cruciate Ligament', 'Range of Motion, Articular', 'Reproducibility o... | 20,870,382 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.110.110', 'E04.650.110', 'E04.680.101.110'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['G01.154.090', 'G01.374.089'], ['C05.116.214'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['E07.695.400.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Current and future health and economic impact of hepatitis C in Belgium. | BACKGROUND AND STUDY AIMS: Chronic hepatitis C virus (HCV) infection is a serious global health problem affecting 150 million individuals worldwide. Although infection rates are decreasing, an aging population with progressing disease is expected to result in increased burden of advanced stage disease with high associa... | ['Antiviral Agents', 'Belgium', 'Health Care Costs', 'Hepatitis C, Chronic', 'Humans', 'Models, Econometric', 'Monte Carlo Method'] | 25,090,835 | [['D27.505.954.122.388'], ['Z01.542.115'], ['N03.219.151.400', 'N05.300.375'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', 'C06.552.380.705.440.120'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.600.500', 'E05.599.835.890.500', 'N05.715.360.750... | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
A multifactor winner-take-all dynamics. | Perceptual systems often have to disentangle different factors from mixed observations. If each factor is represented by a set of variables, each standing for a discrete value of the factor, the factor values underlying an observation can be extracted by a winner-take-all (WTA) mechanism over the direct product of the ... | ['Decision Making', 'Humans', 'Models, Theoretical', 'Neural Networks, Computer', 'Photic Stimulation', 'Recognition, Psychology'] | 21,492,007 | [['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599'], ['G17.485', 'L01.224.050.375.605'], ['E05.723.729'], ['F02.463.425.540.706']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Evaluating an intermittent compression system for thromboembolism prophylaxis. | Patients undergoing orthopaedic or trauma surgery are at high risk of venous thromboembolism, which can lead to deep-vein thrombosis and other complications. However, it is well known that incidence can be greatly reduced with prophylaxis. This article reports on the trial of a new intermittent pneumatic compression de... | ['Adult', 'Aged', 'Aged, 80 and over', 'Attitude of Health Personnel', 'Attitude to Health', 'Benchmarking', 'Clinical Nursing Research', 'Equipment Design', 'Female', 'Hospitals, Urban', 'Humans', 'Intermittent Pneumatic Compression Devices', 'London', 'Male', 'Middle Aged', 'Nursing Staff, Hospital', 'Orthopedic Proc... | 15,624,623 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.100.050', 'N05.300.100'], ['F01.100.150', 'N05.300.150'], ['N04.452.500.150', 'N04.761.685.150', 'N04.761.700.150', 'N05.700.150', 'N05.715.360.650.150'], ['H01.770.644.145.390.234', 'H02.478.395.234', 'N04.590.233.508.613.234'], ['E05.320'], ['N02.2... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non-alcoholic steatohepatitis. | Dicer1 is an enzyme essential for microRNA (miRNA) maturation. The loss of miRNAs resulted from Dicer1 deficiency greatly contributes to the progression of many diseases, including lipid dysregulation, but its role in hepatic accumulation of free cholesterol (FC) that is critical in the development of non-alcoholic ste... | ['Animals', 'Cholesterol', 'DEAD-box RNA Helicases', 'Diet', 'Gene Knockout Techniques', 'Hydroxymethylglutaryl CoA Reductases', 'Male', 'Methionine', 'Mice', 'MicroRNAs', 'Non-alcoholic Fatty Liver Disease', 'RNA, Messenger', 'Ribonuclease III'] | 28,112,179 | [['B01.050'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D08.811.913.696.445.735.720.249'], ['G07.203.650.240'], ['E05.393.335.750'], ['D08.811.682.047.820.150.415'], ['D02.886.030.676', 'D12.125.142.557', 'D12.125.154.549', 'D12.125.166.676'], ['B01.050.150.900.649.313.992.635.505.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Estimating the Hospital Burden of Norovirus-Associated Gastroenteritis in England and Its Opportunity Costs for Nonadmitted Patients. | Background: Norovirus places a substantial burden on healthcare systems, arising from infected patients, disease outbreaks, beds kept unoccupied for infection control, and staff absences due to infection. In settings with high rates of bed occupancy, opportunity costs arise from patients who cannot be admitted due to b... | ['Absenteeism', 'Adult', 'Aged', 'Aged, 80 and over', 'Caliciviridae Infections', 'Cost of Illness', 'Cross Infection', 'Disease Outbreaks', 'England', 'Female', 'Gastroenteritis', 'Hospitalization', 'Humans', 'Infection Control', 'Inpatients', 'Male', 'Middle Aged', 'Norovirus'] | 29,529,135 | [['F02.784.692.107'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C01.925.782.160'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['C01.248', 'C23.550.291.875.500'], ['N06.850.290'], ['Z01.542.363.300'], ['C06.405.205'], ['E02.760.400', 'N02.421.585.400... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hung out to dry: choice of priority ecoregions for conserving threatened neotropical anurans depends on life-history traits. | BACKGROUND: In the Neotropics, nearly 35% of amphibian species are threatened by habitat loss, habitat fragmentation, and habitat split; anuran species with different developmental modes respond to habitat disturbance in different ways. This entails broad-scale strategies for conserving biodiversity and advocates for t... | ['Animal Migration', 'Animals', 'Anura', 'Conservation of Natural Resources', 'Ecosystem', 'Environment', 'Extinction, Biological', 'Life Cycle Stages', 'Population Density', 'Population Dynamics'] | 18,461,175 | [['F01.145.113.069.500'], ['B01.050'], ['B01.050.150.900.090.180'], ['J01.256', 'N06.230.080'], ['G16.500.275.157', 'N06.230.124'], ['G16.500.275', 'N06.230'], ['G16.510'], ['B05.500', 'G07.345.500.550.500'], ['N01.224.600', 'N06.850.505.400.600'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Genetic characterization of an alloalbumin, albumin Kashmir, using gene amplification and allele-specific oligonucleotides. | The molecular basis for albumin Kashmir was studied using the polymerase chain reaction to amplify a DNA fragment containing codon 501 in exon 12 of the human albumin gene. Southern blots of the amplified DNA were hybridized to oligonucleotide probes specific either for the normal allele of albumin or for albumin Kashm... | ['Albumins', 'Alleles', 'Base Sequence', 'Blotting, Southern', 'Humans', 'Molecular Sequence Data', 'Mutation', 'Oligonucleotide Probes', 'Pedigree', 'Polymerase Chain Reaction'] | 2,317,208 | [['D12.776.034'], ['G05.360.340.024.340.030'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G05.365.590'], ['D13.444.600.601', 'D27.505.259.750.600.650', 'D27.720.470.530.600.650'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Energetic stress in combination with tumor necrosis factor-alpha (TNF-alpha) induces apoptosis of human fibroblasts (WI-38) in vitro: reduced responsiveness of senescent cells. | The NaCl content of the culture medium of human fibroblasts (WI-38) was elevated from 0.12 M to 0.23 M. Previously it had been shown that exposure of fibroblasts to such high NaCl conditions resulted in a rise of both glycolysis and respiration ("energetic stress"), mainly due to increased demands of energy for active ... | ['Aged', 'Apoptosis', 'Cell Division', 'Cell Line', 'Cellular Senescence', 'Energy Metabolism', 'Fibroblasts', 'Humans', 'Sodium-Potassium-Exchanging ATPase', 'Tumor Necrosis Factor-alpha', 'Water-Electrolyte Balance'] | 11,828,880 | [['M01.060.116.100'], ['G04.146.954.035'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['G04.043'], ['G03.295'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.040.025.314.750', 'D12.776.157.530.450.162.780', 'D12.776.157.530.450.250.880', ... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Mutagenic effects of asbestos modified by association with ethanol, coffee and tobacco tar]. | The study covered possible modification of mutagenic action of asbestos in combination with widespread agents--ethanol, coffee extractive and fumigating resin. Such modifying effects as antagonism, synergism were revealed as well as an independent action. An attempt was made to extrapolate the obtained data to human ex... | ['Animals', 'Asbestos', 'Coffee', 'Ethanol', 'Mice', 'Mutagenicity Tests', 'Mutagens', 'Smoking', 'Tars'] | 7,953,145 | [['B01.050'], ['D01.578.725.050', 'D01.837.725.700.760.070'], ['D20.215.784.249', 'G07.203.100.325', 'J02.200.325'], ['D02.033.375'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.393.560', 'E05.940.560'], ['D27.888.569.468'], ['F01.145.805'], ['D20.749']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Hydrogen production and enzyme activity of acidophilic strain X-29 at different C/N ratio]. | Some fermentative bacteria can produce hydrogen by utilizing carbohydrate and other kinds of organic compounds as substrates. Hydrogen production was also determined by both the limiting of growth and related enzyme activity in energy metabolism. Carbon and nitrogen are needed for the growth and metabolism of microorga... | ['Bacteria', 'Carbon', 'Hydrogen', 'Hydrogenase', 'Nitrogen'] | 16,768,012 | [['B03'], ['D01.268.150'], ['D01.268.406', 'D01.362.340'], ['D08.811.682.400'], ['D01.268.604', 'D01.362.625']] | ['Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Beehive-Inspired Macroporous SERS Probe for Cancer Detection through Capturing and Analyzing Exosomes in Plasma. | The protein phosphorylation status of exosomes can regulate the activity and function of proteins related to cancer development, and it is highly possible to diagnose cancers through analyzing the protein phosphorylation status. However, monitoring the protein phosphorylation status with a simple and label-free method ... | ['Biomarkers, Tumor', 'Cell Line, Tumor', 'Exosomes', 'Humans', 'Liquid Biopsy', 'Nanoparticles', 'Neoplasms', 'Porosity', 'Spectrum Analysis, Raman', 'Titanium'] | 31,894,690 | [['D23.101.140'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.295.588.750', 'A11.284.430.214.190.875.190.880.495'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.384.100.396', 'E01.370.225.998.054.396', 'E05.200.500.384.100.396', 'E05.200.998.054.396', 'E05.242.384.100.396'], ['J01.637.512.60... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits. | A series of N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines was prepared by reaction of sulfanilamide with different monosaccharides in the presence of ammonium chloride. The new compounds were investigated for inhibition of the metallo-enzyme carbonic anhydrase (CA, EC 4.2.1.1), involved in aqueous humor secretion ... | ['Administration, Topical', 'Animals', 'Antihypertensive Agents', 'Carbonic Anhydrase Inhibitors', 'Glaucoma', 'Hypertension', 'Intraocular Pressure', 'Male', 'Monosaccharides', 'Rabbits', 'Sulfanilamides'] | 14,684,332 | [['E02.319.267.120'], ['B01.050'], ['D27.505.954.411.162'], ['D27.505.519.389.200'], ['C11.525.381'], ['C14.907.489'], ['G14.440'], ['D09.947.875'], ['B01.050.150.900.649.313.968.700'], ['D02.065.884.725', 'D02.092.146.807', 'D02.886.590.700.725']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dietary vitamin A modulates the properties of retinoic acid and glucocorticoid receptors in rat liver. | Properties of retinoic acid receptors and glucocorticoid receptors of rat liver were influenced by retinol status in a nonsimilar manner. The binding of the retinoic acid receptors which was lowered in vitamin A--deficient animals relative to controls was restored by a single dose (100 micrograms) of retinoic acid; in ... | ['Administration, Oral', 'Alcohol Dehydrogenase', 'Animals', 'Binding Sites', 'Carrier Proteins', 'Liver', 'Male', 'Rats', 'Rats, Wistar', 'Receptors, Glucocorticoid', 'Receptors, Retinoic Acid', 'Tyrosine Transaminase', 'Vitamin A', 'Vitamin A Deficiency'] | 8,100,575 | [['E02.319.267.100'], ['D08.811.682.047.820.250'], ['B01.050'], ['G02.111.570.120'], ['D12.776.157'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D12.776.826.750.430'], ['D12.776.826.701', 'D12.776.930.775'], ['D08.811.913.477.700.900'], ['D02.455.326.271... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Poly(methyl vinyl ether-alt-maleic acid) polymers for cell encapsulation. | Polyanions based on poly(methyl vinyl ether-alt-maleic acid) were investigated as materials for cell encapsulation. These water-soluble polyanions having molecular masses ranging from 20 to 1980 kDa were prepared by functionalization of poly(methyl vinyl ether-alt-maleic anhydride) with 5-aminofluorescein and/or á-meth... | ['Alginates', 'Animals', 'Cattle', 'Cell Engineering', 'Cell Line', 'Cell Survival', 'Drug Compounding', 'Fluoresceins', 'Maleates', 'Methyl Ethers', 'Mice', 'Molecular Structure', 'Polymers', 'Polyvinyls'] | 21,067,656 | [['D09.698.068'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.481.500.311', 'J01.293.069.249'], ['A11.251.210'], ['G04.346'], ['E05.916.270'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['D02.241.081.337.502'], ['D02.355.601'], ['B01.050.150.900.649.313.992.635.505.500'], ['G02.111.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Extracellular guanosine and GTP promote expression of differentiation markers and induce S-phase cell-cycle arrest in human SH-SY5Y neuroblastoma cells. | SH-SY5Y neuroblastoma cells, a model for studying neuronal differentiation, are able to differentiate into either cholinergic or dopaminergic/adrenergic phenotypes depending on media conditions. Using this system, we asked whether guanosine (Guo) or guanosine-5'-triphosphate (GTP) are able to drive differentiation towa... | ['Cell Line, Tumor', 'Cyclin B', 'Cyclin B1', 'Cyclin B2', 'Cyclin-Dependent Kinase 2', 'Cyclins', 'Down-Regulation', 'Extracellular Space', 'GAP-43 Protein', 'Guanosine', 'Guanosine Triphosphate', 'Humans', 'Membrane Potentials', 'Microtubule-Associated Proteins', 'Neurites', 'Neurogenesis', 'Neurons', 'S Phase', 'Tyr... | 19,111,604 | [['A11.251.210.190', 'A11.251.860.180'], ['D12.644.360.262.120', 'D12.776.167.218.120', 'D12.776.476.262.120'], ['D12.644.360.262.120.100', 'D12.776.167.218.120.100', 'D12.776.476.262.120.100'], ['D12.644.360.262.120.200', 'D12.776.167.218.120.200', 'D12.776.476.262.120.200'], ['D08.811.913.696.620.682.700.646.500.750'... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Activity Levels for Four Years in a Cohort of Urban-Dwelling Adolescent Females. | PURPOSE: Evidence suggests that female adolescents and those living in urban environments may have lower physical activity (PA) levels compared with their peers. Yet few studies report PA for urban adolescent females, and there is no consensus regarding potential causes for low PA in this subgroup. We examined PA level... | ['Actigraphy', 'Adolescent', 'Age Factors', 'Environment Design', 'Exercise', 'Female', 'Humans', 'Life Style', 'Pennsylvania', 'Residence Characteristics', 'Schools', 'Socioeconomic Factors', 'Urban Population'] | 27,875,500 | [['E01.370.520.049', 'E05.003.500'], ['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['I01.283', 'I01.880.709.359', 'N06.230.145'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458'], ['Z01.107.567.875.075.550', 'Z01.107.567.875.350.550', 'Z01.107.567.875.500.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Characterization of erythrocyte membrane tension for hemolysis prediction in complex flows. | Hemolysis is a persistent issue with blood-contacting devices. Many experimental and theoretical contributions over the last few decades have increased insight into the mechanisms of hemolysis in both laminar and turbulent flows, with the ultimate goal of developing a comprehensive, mechanistic hemolysis model. Many mo... | ['Biomechanical Phenomena', 'Erythrocyte Membrane', 'Hemolysis', 'Hemorheology', 'Imaging, Three-Dimensional', 'Stress, Mechanical', 'Viscosity'] | 29,299,699 | [['G01.154.090', 'G01.374.089'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['C23.550.403', 'G12.122.545'], ['E05.830.250', 'G09.188.370', 'G09.330.380.630'], ['E01.370.350.400', 'L01.224.308.410'], ['G01.374.835'], ['G02.930']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Intracranial angiomatoid fibrous histiocytoma with Hodgkin lymphoma. | Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumour of uncertain differentiation and low metastatic potential, which occurs predominantly in children and young adults. It occurs mostly within the extremities, trunk, head and neck. We report the case of a 32-year-old female that was operated in our hospi... | ['Adult', 'Brain Neoplasms', 'Female', 'Histiocytoma, Malignant Fibrous', 'Hodgkin Disease', 'Humans'] | 31,256,181 | [['M01.060.116'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C04.557.450.565.590.425.360', 'C04.557.450.795.400'], ['C04.557.386.355', 'C15.604.515.569.355', 'C20.683.515.761.355'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The guanine-nucleotide-exchange factor Cdc24p is targeted to the nucleus and polarized growth sites. | Generation of cellular asymmetry or cell polarity plays a critical role in cell-cycle-regulated morphogenetic processes involving the actin cytoskeleton. The GTPase Cdc42 regulates actin rearrangements and signal transduction pathways in all eukaryotic cells [1], and the temporal and spatial regulation of Cdc42p depend... | ['Binding Sites', 'Cell Cycle', 'Cell Cycle Proteins', 'Cell Nucleus', 'Cell Polarity', 'Cyclin-Dependent Kinases', 'DNA-Binding Proteins', 'Fungal Proteins', 'Green Fluorescent Proteins', 'Guanine Nucleotide Exchange Factors', 'Luminescent Proteins', 'Proto-Oncogene Proteins', 'Recombinant Fusion Proteins', 'Saccharom... | 10,531,032 | [['G02.111.570.120'], ['G04.144'], ['D12.776.167'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['G04.250'], ['D08.811.913.696.620.682.700.646.500', 'D12.644.360.250', 'D12.776.167.200', 'D12.776.476.250'], ['D12.776.260'], ['D12.776.354'], ['D12.776.532.265'], ['D12.644.360.325.300', 'D12.776.476.325.300'], ['... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Augmented anti-acetylcholine receptor response following long-term penicillamine administration. | Because of the association of D-penicillamine (DP) therapy with myasthenia gravis, we have studied long-term DP treatment in five inbred strains of mice with doses comparable to those used in patients with rheumatoid arthritis. No clinical weakness or anti-acetylcholine receptor (AChR) antibody developed with up to 6 m... | ['Animals', 'Autoantibodies', 'Edrophonium', 'Female', 'Long-Term Care', 'Membrane Potentials', 'Mice', 'Mice, Inbred Strains', 'Motor Endplate', 'Myasthenia Gravis', 'Penicillamine', 'Receptors, Cholinergic', 'Species Specificity'] | 6,431,900 | [['B01.050'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D02.092.877.674.333', 'D02.675.276.352'], ['E02.760.476', 'N02.421.585.476'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The reorganization of functional architecture in the early-stages of Parkinson's disease. | INTRODUCTION: The study aim was to identify longitudinal abnormalities of functional connectivity and its relation with motor disability in early to moderately advanced stages of Parkinson's disease patients.METHODS: 3.0T structural and resting-state functional MRI was performed in healthy subjects (n = 16) and Parkins... | ['Cerebellum', 'Cerebrum', 'Connectome', 'Humans', 'Longitudinal Studies', 'Magnetic Resonance Imaging', 'Parkinson Disease'] | 29,449,186 | [['A08.186.211.132.810.428.200'], ['A08.186.211.200.885.287'], ['E01.370.350.578.875.500.249', 'E01.370.376.537.625.500.249', 'E05.629.875.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['E01.370.350.825.500'], ['C10... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging. | Organelles of the neuronal secretory pathway are critical for the addition of membrane that accompanies neuronal development, as well as for the proper localization of plasma membrane proteins necessary for polarity, synaptic transmission, and plasticity. Here, we demonstrate that two organizations of the secretory pat... | ['Animals', 'Brain-Derived Neurotrophic Factor', 'Cell Compartmentation', 'Cells, Cultured', 'Dendrites', 'Endoplasmic Reticulum', 'Golgi Apparatus', 'Green Fluorescent Proteins', 'Hippocampus', 'Immunohistochemistry', 'Internet', 'Luminescent Proteins', 'Membrane Glycoproteins', 'Microscopy, Confocal', 'Neurons', 'Pro... | 12,867,502 | [['B01.050'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['G04.128'], ['A11.251'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['A11.284.430.214.190.875.248'], ['A11.284.430.214.190.875.336'], ['D12.776.532.265'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Spontaneous regression of Friend-virus-induced erythroleukemia. VII. The genetic control of regression. | The genetic control of spontaneous regression of erythroleukemia was studied in parental and hybrid mice in which leukemia was induced by the regressing strain of Friend virus (RFV). Because in previous studies parental regressor mouse strains tested (N/PLCR, SIM, NIH Swiss) all had the FV-1n/n genotype and the progres... | ['Alleles', 'Animals', 'Friend murine leukemia virus', 'Genotype', 'Leukemia, Erythroblastic, Acute', 'Leukemia, Experimental', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Neoplasm Regression, Spontaneous'] | 6,945,295 | [['G05.360.340.024.340.030'], ['B01.050'], ['B04.613.807.375.525.225', 'B04.820.650.375.525.225'], ['G05.380'], ['C04.557.337.539.275.325', 'C15.378.190.636.276'], ['C04.557.337.372', 'C04.619.531', 'E05.598.500.496.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development and preliminary validation of a Chinese version of the Buss-Perry Aggression Questionnaire in a population of Hong Kong Chinese. | I developed a Chinese version of the Aggression Questionnaire (Buss & Perry, 1992) by translating scale items into Chinese and subjecting them to standard validation procedures. I used confirmatory factor analysis via structural equation modeling to compare several measurement models. Models based on Buss and Perry's (... | ['Adolescent', 'Adult', 'Aggression', 'Anger', 'China', 'Conduct Disorder', 'Cross-Cultural Comparison', 'Female', 'Hong Kong', 'Humans', 'Male', 'Personality Assessment', 'Surveys and Questionnaires'] | 17,518,550 | [['M01.060.057'], ['M01.060.116'], ['F01.145.126.125', 'F01.145.813.045'], ['F01.470.093'], ['Z01.252.474.164'], ['F03.625.094.300'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['Z01.252.474.164.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.513'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Radiolocalization of sentinel lymph nodes in clinically N0 laryngeal and hypopharyngeal cancers. | OBJECTIVES: We sought to analyze the characteristics of radioactive lymph nodes with metastatic disease and to explore methods for the localization of sentinel lymph nodes (SLNs) with radionuclide in clinically N0 laryngeal and hypopharyngeal cancer.METHODS: Forty-five patients with T1-T4 and clinically N0 laryngeal an... | ['Adult', 'Aged', 'Diagnosis, Differential', 'Female', 'Follow-Up Studies', 'Humans', 'Hypopharyngeal Neoplasms', 'Laryngeal Neoplasms', 'Lymph Nodes', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neck', 'Neoplasm Staging', 'Prognosis', 'Radionuclide Imaging', 'Radiopharmaceuticals', 'Reproducibility of Results', 'R... | 21,675,592 | [['M01.060.116'], ['M01.060.116.100'], ['E01.171'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.665.710.485', 'C07.550.745.436', 'C09.647.710.485', 'C09.775.549.485'], ['C04.588.443.665.481', 'C08.360.369', 'C0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Demographic characteristics of the equine population of northern Britain. | The size, composition and distribution of the equine population of Scotland and the five northernmost counties in England were estimated through a series of mailed questionnaire surveys of sentinel veterinary practices and horse owners. An estimated 96,622 equine animals were kept by an estimated 26,114 owners. The mea... | ['Animals', 'Demography', 'England', 'Female', 'Horses', 'Male', 'Population', 'Scotland', 'Surveys and Questionnaires'] | 10,515,615 | [['B01.050'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.984.235.472'], ['N01.600'], ['Z01.542.363.766'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Serial changes in liver stiffness and controlled attenuation parameter following direct-acting antiviral therapy against hepatitis C virus genotype 1b. | Little information is available on the impact of direct-acting antiviral (DAA) therapy on changes in liver fibrosis and steatosis. Liver stiffness (LS) and controlled attenuation parameter (CAP) values were evaluated using transient elastography. The study subjects were 214 elderly patients infected with HCV genotype 1... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antiviral Agents', 'Elasticity Imaging Techniques', 'Female', 'Genotype', 'Hepacivirus', 'Hepatitis C, Chronic', 'Humans', 'Imidazoles', 'Isoquinolines', 'Liver', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Retrospective Studies', 'Sulfonamides', 'Sustained Virologic Response... | 28,906,010 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.388'], ['E01.370.350.850.270'], ['G05.380'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', 'C06.552.380.705.440.120'], ['B01.050.150.900.649.313.98... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Case study approach to modeling historical disinfection by-product exposure in Iowa drinking waters. | In the 1980s, a case-control epidemiologic study was conducted in Iowa (USA) to analyze the association between exposure to disinfection by-products (DBPs) and bladder cancer risk. Trihalomethanes (THMs), the most commonly measured and dominant class of DBPs in drinking water, served as a primary metric and surrogate f... | ['Disinfection', 'Drinking Water', 'Environmental Exposure', 'Follow-Up Studies', 'Humans', 'Iowa', 'Models, Chemical', 'Neoplasms', 'Risk Assessment', 'Trihalomethanes', 'Water Pollutants, Chemical', 'Water Purification', 'Water Supply'] | 28,774,607 | [['N06.850.780.200.450.850.375'], ['D01.045.250.875.300', 'D01.248.497.158.459.650.300', 'D01.650.550.925.199', 'G07.203.100.418', 'J02.200.418'], ['N06.850.460.350'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.56... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Immunoelectron microscopic demonstration of pancreatic polypeptide in midgut epithelium of hematophagous dipterans. | Midguts of mosquitoes, Aedes aegypti and Anopheles stephensi, and of the tsetse fly, Glossina morsitans morsitans, as well as guinea pig pancreas, were prepared for electron microscopy by using low-temperature embedding in Lowicryl K4M. Rabbit antiserum to bovine pancreatic polypeptide (PP) crossreacted with secretory ... | ['Aedes', 'Animals', 'Anopheles', 'Endocrine Glands', 'Epithelium', 'Gold', 'Immunologic Techniques', 'Intestinal Mucosa', 'Microscopy, Electron', 'Pancreatic Polypeptide', 'Somatostatin', 'Tsetse Flies'] | 2,885,369 | [['B01.050.500.131.617.720.500.500.750.712.500.875.100'], ['B01.050'], ['B01.050.500.131.617.720.500.500.750.712.500.875.120'], ['A06.300'], ['A10.272'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['E05.478'], ['A03.556.124.369', 'A10.615.550.444'], ['E01.370.350.515.402', 'E05.595.402'], ['D06.472.699.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Variants of intrafamilial sexual abuse experience: implications for short- and long-term development. | This study examines short- and long-term maladaptive outcomes in a sample of sexually abused females and a comparison group. The sample consists of intrafamilial sexual abuse victims ages 6-16 years at entry into the study and a demographically similar comparison group. The outcomes examined included measures of behavi... | ['Adolescent', 'Aggression', 'Child', 'Child Abuse, Sexual', 'Child Behavior Disorders', 'Depression', 'Dissociative Disorders', 'Domestic Violence', 'Female', 'Follow-Up Studies', 'Humans', 'Incest', 'Personality Development', 'Risk Factors', 'Self Concept', 'Social Adjustment'] | 11,771,904 | [['M01.060.057'], ['F01.145.126.125', 'F01.145.813.045'], ['M01.060.406'], ['I01.198.240.748.300', 'I01.198.240.856.350.250.255', 'I01.880.735.900.350.250.255'], ['F03.625.141'], ['F01.145.126.350'], ['F03.300'], ['I01.198.240.856.350', 'I01.880.735.900.350'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Effect of aggregation and shear rate on the dispersion of red blood cells flowing in venules. | Previous in vitro studies of blood flow in small glass tubes have shown that red blood cells exhibit significant erratic deviations in the radial position in the laminar flow regime. The purpose of the present study was to assess the magnitude of this variability and that of velocity in vivo and the effect of red blood... | ['Animals', 'Anticoagulants', 'Blood Flow Velocity', 'Blood Pressure', 'Blood Viscosity', 'Cell Aggregation', 'Dextrans', 'Erythrocytes', 'Hematocrit', 'Male', 'Models, Cardiovascular', 'Muscle, Skeletal', 'Particle Size', 'Rats', 'Rats, Sprague-Dawley', 'Stress, Mechanical', 'Venules'] | 12,384,477 | [['B01.050'], ['D27.505.954.502.119'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.188.370.124', 'G09.330.380.630.110'], ['G04.198.251'], ['D05.750.078.562.272', 'D09.698.365.272'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['E01.370.225.625.400', 'E05.200.625.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Culture of Rectal Swab Specimens for Enteric Bacterial Pathogens Decreases Time to Test Result While Preserving Assay Sensitivity Compared to Bulk Fecal Specimens. | Diarrheal illness is a major cause of morbidity and mortality throughout the world, yet the etiologic agent of many cases of gastrointestinal illness remains unspecified, often due to the lack of convenient, timely, and sensitive diagnostic testing. Although bulk fecal specimens remain the recommended specimen type for... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Bacterial Typing Techniques', 'Child', 'Child, Preschool', 'Diarrhea', 'Feces', 'Female', 'Gastroenteritis', 'Gastrointestinal Microbiome', 'Humans', 'Male', 'Middle Aged', 'Rectum', 'Retrospective Studies', 'Sensitivity and Specificity', 'Specimen Handling', 'Young... | 30,944,186 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['M01.060.406'], ['M01.060.406.448'], ['C23.888.821.214'], ['A12.459'], ['C06.405.205'], ['G06.591.375', 'G16.500.275.157.049.100.500.375', 'N06.230.124.049.100.500.250'], ['B01.050.150.9... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Detection of base-pair mismatches in DNA using graphene-based nanopore device. | We present a unique way to detect base-pair mismatches in DNA, leading to a different epigenetic disorder by the method of nanopore sequencing. Based on a tight-binding formulation of a graphene-based nanopore device, using the Green's function approach we study the changes in the electronic transport properties of the... | ['Algorithms', 'Base Pair Mismatch', 'Base Pairing', 'DNA', 'Epigenesis, Genetic', 'Graphite', 'Nanopores', 'Sequence Analysis, DNA'] | 26,894,508 | [['G17.035', 'L01.224.050'], ['G05.365.590.060'], ['G02.111.570.820.486.100', 'G02.111.611.500', 'G05.360.580.100'], ['D13.444.308'], ['G05.308.203'], ['D01.268.150.300', 'D01.578.300'], ['J01.637.512.650'], ['E05.393.760.700']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Rural healthcare providers question the practicality of motivational interviewing and report varied physical activity counseling experience. | OBJECTIVE: To evaluate rural healthcare providers (HCP) physical activity (PA) counseling experiences and perceptions of motivational interviewing (MI), a behavioral counseling style, prior to MI training.METHODS: Four moderator-led focus groups were conducted among rural HCPs providing care to rural African American w... | ['Adult', 'African Americans', 'Communication', 'Directive Counseling', 'Female', 'Focus Groups', 'Health Promotion', 'Humans', 'Interviews as Topic', 'Male', 'Middle Aged', 'Motivation', 'Motor Activity', 'Nurse-Patient Relations', 'Qualitative Research', 'Rural Health Services', 'Rural Population', 'Social Perception... | 19,201,141 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['F01.145.209', 'L01.143'], ['F02.784.176.279', 'F04.408.413.349', 'N02.421.461.363.349'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.3... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', '... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
[Therapeutic efficacy and quality of life investigation of traditional Chinese medicine-based therapy of chronic hepatitis B-related liver fibrosis]. | OBJECTIVE: To prospectively evaluate the efficacy of a traditional Chinese medicine (TCM)-based therapy for treating liver fibrosis in patients with chronic hepatitis B (CHB), and to investigate the patients' perception of the treatment's effects on quality of life (QoL).METHODS: A total of 430 patients with CHB-relate... | ['Adult', 'Antiviral Agents', 'Drug Therapy, Combination', 'Drugs, Chinese Herbal', 'Female', 'Guanine', 'Hepatitis B, Chronic', 'Humans', 'Liver Cirrhosis', 'Male', 'Middle Aged', 'Phytotherapy', 'Quality of Life', 'Treatment Outcome'] | 24,721,240 | [['M01.060.116'], ['D27.505.954.122.388'], ['E02.319.310'], ['D20.215.784.500.350', 'D26.335'], ['D03.633.100.759.758.399.454'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925.440.435.100', 'C06.552.380.350.100', 'C06.552.380.705.437.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.630', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Intracellular distribution of the La antigen in CV-1 cells after herpes simplex virus type 1 infection compared with the localization of U small nuclear ribonucleoprotein particles. | The La antigen is known to associate, at least transiently, with a series of small nuclear and cytoplasmic ribonucleoprotein particles (snRNPs and scRNPs), e.g. U1 and U6 snRNPs. In CV-1 cells a monoclonal antibody (MAb), directed against the La protein (La1B5), immunostained intranuclear speckles. These speckles were ... | ['Antibodies, Monoclonal', 'Autoantigens', 'Cell Line', 'Cell Nucleus', 'Cytoplasm', 'Fluorescent Antibody Technique', 'Humans', 'Immunoblotting', 'Mutation', 'Ribonucleoproteins', 'Ribonucleoproteins, Small Nuclear', 'Simplexvirus', 'Transcription Factors'] | 2,543,764 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.422'], ['A11.251.210'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.214'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoscopic-guided versus cotton-tipped applicator methods of nasal anesthesia for transnasal esophagogastroduodenoscopy: a randomized, prospective, controlled study. | BACKGROUND: Ultrathin transnasal esophagogastroduodenoscopy (UT-EGD) is well tolerated by patients, but the methods of nasal anesthesia are various.AIM: To compare patient tolerance, safety, and adverse events between the endoscopic-guided (EGNA) and cotton-tipped applicator (CTNA) methods of nasal anesthesia.METHODS: ... | ['Administration, Intranasal', 'Adolescent', 'Adult', 'Aged', 'Anesthesia, Local', 'Endoscopes', 'Endoscopy, Digestive System', 'Epinephrine', 'Female', 'Humans', 'Lidocaine', 'Male', 'Middle Aged', 'Pain Measurement', 'Patient Satisfaction', 'Taiwan', 'Turbinates'] | 18,445,099 | [['E02.319.267.120.655.500'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E03.155.086.231'], ['E07.230.220', 'E07.858.240'], ['E01.370.372.250', 'E01.370.388.250.250', 'E04.210.240', 'E04.502.250.250'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.55... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The potential for polyphosphate metabolism in Archaea and anaerobic polyphosphate formation in Methanosarcina mazei. | Inorganic polyphosphate (polyP) is ubiquitous across all forms of life, but the study of its metabolism has been mainly confined to bacteria and yeasts. Few reports detail the presence and accumulation of polyP in Archaea, and little information is available on its functions and regulation. Here, we report that homolog... | ['Anaerobiosis', 'Archaeal Proteins', 'Methanosarcina', 'Phosphotransferases (Phosphate Group Acceptor)', 'Polyphosphates'] | 31,745,137 | [['G02.111.062', 'G03.078'], ['D12.776.090'], ['B02.200.765.550.550'], ['D08.811.913.696.650'], ['D01.029.260.700.675.374.775', 'D01.248.497.158.730.650', 'D01.695.625.675.650.775']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immune response to minor variant antigen types (VATs) in a mixed VAT infection of the African trypanosomes. | It has been shown that soon after the onset of acute infection with Trypanosoma brucei gambiense, mice are able to detect immunologically small numbers of minor variant antigen types (VATs) within the population. However, in more longstanding infections, considerably larger populations of minor VATs are required to sti... | ['Animals', 'Antibodies, Protozoan', 'Antigenic Variation', 'Eflornithine', 'Immune Tolerance', 'Mice', 'Trypanosoma brucei gambiense', 'Trypanosomiasis, African', 'Variant Surface Glycoproteins, Trypanosoma'] | 3,143,096 | [['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['G05.365.073', 'G12.500.249'], ['D12.125.068.665.340', 'D12.125.095.765.340'], ['G12.535.425'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.268.475.868.887.110'], ['C01.610.752.300.900.719', 'C01.920.937... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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