Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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[Mitochondrial DNA diversity in prehispanic bone remains on the eastern Colombian Andes]. | INTRODUCTION: DNA extracted from ancient human bones allows to analyze the genetic makeup of pre-Columbian populations and to determine the dynamics that gave rise to the diversity of contemporary populations.OBJECTIVE: To determine the genetic diversity of skeletal remains associated with the Templo del Sol (Sun Templ... | ['Amelogenin', 'Bone and Bones', 'Chromosomes, Human, Y', 'Colombia', 'DNA, Mitochondrial', 'Female', 'Genetic Markers', 'Genetic Variation', 'Haplotypes', 'History, Ancient', 'History, Medieval', 'Humans', 'Indians, South American', 'Male', 'Phylogeny', 'Polymorphism, Restriction Fragment Length', 'Sequence Analysis, ... | 29,373,774 | [['D12.776.231.500'], ['A02.835.232', 'A10.165.265'], ['A11.284.187.520.300.505.757', 'A11.284.187.865.983.500', 'G05.360.162.520.300.505.757', 'G05.360.162.865.983.500'], ['Z01.107.757.284'], ['D13.444.308.283.225'], ['D23.101.387', 'G05.695.450'], ['G05.365'], ['G05.380.360'], ['K01.400.470'], ['K01.400.500'], ['B01.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Named Groups [M]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 |
Frog population viability under present and future climate conditions: a Bayesian state-space approach. | 1. World-wide extinctions of amphibians are at the forefront of the biodiversity crisis, with climate change figuring prominently as a potential driver of continued amphibian decline. As in other taxa, changes in both the mean and variability of climate conditions may affect amphibian populations in complex, unpredicta... | ['Animals', 'Anura', 'Bayes Theorem', 'Climate Change', 'Conservation of Natural Resources', 'Extinction, Biological', 'Models, Biological', 'Montana', 'Population Dynamics'] | 22,574,643 | [['B01.050'], ['B01.050.150.900.090.180'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['G16.500.175.374'], ['J01.256', 'N06.230.080'], ['G16.510'], ['E05.599.395'], ['Z01.107.567.875.560.500'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Isolated osteochondral fracture of the metatarsal head of lesser toes. | Isolated fracture of the metatarsal head is very rare and no consensus has been reached regarding their best management. We reported four cases of isolated osteochondral fracture of the metatarsal head with different method of treatment to achieve the common goal of restoration of the congruity of the metatarsal head. | ['Adolescent', 'Adult', 'Female', 'Foot Injuries', 'Fractures, Bone', 'Fractures, Cartilage', 'Humans', 'Male', 'Metatarsal Bones', 'Radiography', 'Toes'] | 25,937,421 | [['M01.060.057'], ['M01.060.116'], ['C26.558.300'], ['C26.404'], ['C26.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.043.300.492'], ['E01.370.350.700'], ['A01.378.610.250.300.792']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway. | Hypoxic microenvironment, a common feature of pancreatic cancer, is associated with tumor proliferation, metastasis and epithelial-mesenchymal transition (EMT) changes. In recent years, many natural agents, including curcumin, have been proven to possess the ability to inhibit the progression of pancreatic cancer. Howe... | ['Antineoplastic Agents', 'Cadherins', 'Cell Hypoxia', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Curcumin', 'Epithelial-Mesenchymal Transition', 'Hedgehog Proteins', 'Humans', 'Neoplasm Invasiveness', 'Pancreatic Neoplasms', 'Signal Transduction', 'Smoothened Receptor', 'Vimentin', 'Wound Healing', 'Z... | 27,035,865 | [['D27.505.954.248'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['G03.197.300', 'G04.270.300'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D02.455.326.146.485.222.222', 'D02.455.426.559.389.657.166.200', 'D02.455... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prolactin stimulation of Nb 2 node lymphoma cell division is inhibited by polyamine biosynthesis inhibitors. | The mitogenic action of prolactin in Nb 2 node lymphoma cells was inhibited by two drugs which interfere with polyamine biosynthesis. At concentrations of 0.5 mM and above alpha-difluoromethyl ornithine (DFMO), which inhibits ornithine decarboxylase and the conversion of ornithine to putrescine, significantly attenuate... | ['Adenosylmethionine Decarboxylase', 'Animals', 'Cell Division', 'Cell Line', 'Drug Interactions', 'Eflornithine', 'Lymphoma', 'Mitoguazone', 'Ornithine', 'Ornithine Decarboxylase Inhibitors', 'Polyamines', 'Prolactin', 'Rats'] | 3,931,086 | [['D08.811.520.224.125.050'], ['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['G07.690.773.968'], ['D12.125.068.665.340', 'D12.125.095.765.340'], ['C04.557.386', 'C15.604.515.569', 'C20.683.515.761'], ['D02.078.370.600'], ['D12.125.068.665', 'D12.125.095.765'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of selective dropout on infant growth standards. | Exclusively breastfed (EBF) infants have higher weight gain during the first 2 months, and lower thereafter. The explanation for this phenomenon is not clear. Longitudinal data from the Social Medical Survey of Children Attending Child Health Clinics study with a cohort of 2,151 Dutch children were analyzed according t... | ['Age Factors', 'Body Weight', 'Breast Feeding', 'Growth', 'Health Care Surveys', 'Humans', 'Infant', 'Longitudinal Studies', 'Netherlands', 'Patient Dropouts', 'Reference Values', 'Weight Gain', 'World Health Organization'] | 20,139,681 | [['N05.715.350.075', 'N06.850.490.250'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['G07.345.249'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210... | ['Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
First experience with zero-fluoroscopic ablation for supraventricular tachycardias using a novel impedance and magnetic-field-based mapping system. | AIMS: Zero- and near-zero-fluoroscopic ablation techniques reduce the harmful effects of ionizing radiation during invasive electrophysiology procedures. We aimed to test the feasibility and safety of a zero-fluoroscopic strategy using a novel integrated magnetic and impedance-based electroanatomical mapping system for... | ['Accessory Atrioventricular Bundle', 'Action Potentials', 'Adult', 'Aged', 'Atrial Flutter', 'Catheter Ablation', 'Electrophysiologic Techniques, Cardiac', 'Feasibility Studies', 'Female', 'Fluoroscopy', 'Heart Rate', 'Humans', 'Magnetics', 'Male', 'Middle Aged', 'Operative Time', 'Predictive Value of Tests', 'Radiati... | 29,476,203 | [['C23.300.190'], ['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['M01.060.116'], ['M01.060.116.100'], ['C14.280.067.248', 'C23.550.073.248'], ['E02.808.750.500', 'E04.014.760.500'], ['E01.370.370.380.245', 'E01.370.405.267'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Decreased regional gray matter volume in suicide attempters compared to suicide non-attempters with major depressive disorders. | OBJECTIVE: This study investigated regional gray matter (GM) volume differences between suicide attempters and suicide non-attempters with major depressive disorder (MDD) and their relationship with psychological risk factors for suicidality.METHODS: MDD patients with and without a suicide attempt history (n=19 in each... | ['Adult', 'Cerebellum', 'Depressive Disorder, Major', 'Female', 'Gray Matter', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Organ Size', 'Parietal Lobe', 'Psychiatric Status Rating Scales', 'Suicidal Ideation', 'Suicide', 'Suicide, Attempted'] | 27,095,336 | [['M01.060.116'], ['A08.186.211.132.810.428.200'], ['F03.600.300.375'], ['A08.186.211.168', 'A08.186.854.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['A08.186.211.200.885.287.5... | ['Named Groups [M]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Heterogeneous survival rates for isolated skeletal metastases from melanoma. | In this study, the authors examine the survivorship of individuals who constitute the small subset of patients with Stage IV melanoma who present with their first and only detectable metastasis to the skeleton. One thousand two hundred six patients were identified with primary melanoma at the authors' institution since... | ['Adult', 'Aged', 'Bone Neoplasms', 'Female', 'Humans', 'Male', 'Melanoma', 'Middle Aged', 'Skin Neoplasms', 'Survival Analysis', 'Uveal Neoplasms'] | 8,625,592 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.149', 'C05.116.231'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['M01.060.116.630'], ['C04.588.805', 'C17.800.882'], ['E05.318.740.998', 'N05.715.360.750.795', 'N06.850.520.830.998'], ['C04... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Tobacco mosaic virus as an AFM tip calibrator. | The study of high-resolution topographic surfaces of isolated single molecules is one of the applications of atomic force microscopy (AFM). Since tip-induced distortions are significant in topographic images the exact AFM tip shape must be known in order to correct dilated AFM height images using mathematical morpholog... | ['Microscopy, Atomic Force', 'Tobacco Mosaic Virus'] | 21,504,029 | [['E01.370.350.515.666.400', 'E05.595.666.400'], ['B04.715.464.725.800', 'B04.820.578.844.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Establishment of a lentivirus-mediated rapid eukaryotic expression system of novel avian influenza H7N9 virus hemagglutinin gene]. | OBJECTIVE: To establish a rapid eukaryotic expression system of hemagglutinin (HA) gene of novel avian influenza H7N9 using lentiviral vector, express the recombinant protein and study its functions in human embryonic kidney HEK293T cells.METHODS: The full-length HA gene was amplified from H7N9 genomic RNA by reverse t... | ['Animals', 'Birds', 'Blotting, Western', 'Fluorescent Antibody Technique, Indirect', 'Gene Expression', 'Genetic Vectors', 'HEK293 Cells', 'Hemagglutination Tests', 'Hemagglutinin Glycoproteins, Influenza Virus', 'Humans', 'Influenza A Virus, H7N9 Subtype', 'Influenza in Birds', 'Influenza, Human', 'Lentivirus', 'Mole... | 24,909,287 | [['B01.050'], ['B01.050.150.900.248'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E01.370.225.500.607.512.240.310', 'E01.370.225.750.551.512.240.310', 'E05.200.500.607.512.240.310', 'E05.200.750.551.512.240.310', 'E05.478.583.375.310'], ['G05.297'], ['G05.360.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular basis of UV-sensitive mutant strain MBH3 of Haemophilus influenzae Rd: identification of mutation in the uvrA gene. | We have previously reported on cloning a DNA repair gene designated as uvr3 by virtue of its ability to phenotypically complement the UV sensitivity of mutant strain MBH3. Subsequently, we identified the uvr3 gene to be the uvrA gene (gene identification number HI0249) of Haemophilus influenzae Rd. The uvrA gene is a c... | ['Adenosine Triphosphatases', 'Bacterial Proteins', 'DNA-Binding Proteins', 'Escherichia coli Proteins', 'Haemophilus influenzae', 'Mutation', 'Ultraviolet Rays'] | 11,215,703 | [['D08.811.277.040.025'], ['D12.776.097'], ['D12.776.260'], ['D12.776.097.275'], ['B03.440.450.600.450.330', 'B03.660.250.550.290.330'], ['G05.365.590'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G16.500.275.063.725.525.600', 'G16.500.750.775.525.60... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
What features improve the accuracy of the clinical diagnosis of progressive supranuclear palsy-parkinsonism (PSP-P)? | Progressive supranuclear palsy-parkinsonism (PSP-P) is a primary tauopathy characterised by neurofibrillary degeneration, which is frequently mistaken for Parkinson's disease (PD), multiple system atrophy (MSA), and vascular parkinsonism (VP) at presentation. The aim of this study was to identify particular clinical fe... | ['Adult', 'Aged', 'Aged, 80 and over', 'Chi-Square Distribution', 'Diagnosis, Differential', 'Female', 'Humans', 'Male', 'Middle Aged', 'Parkinsonian Disorders', 'Retrospective Studies', 'Supranuclear Palsy, Progressive'] | 20,108,379 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.228.140.079.862', 'C10.228.662.600'], ['E05.318.372.500.500.500', 'E05.31... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Expressions of Axl and Tyro-3 receptors are under regulation of nerve growth factor and are involved in differentiation of PC12 cells. | OBJECTIVE: Tyro-3 and Axl receptors are expressed in brain in a region-specific manner and their bioactivities in the central nervous system remain still elusive. The aim of the present study was to investigate their functions in neuronal differentiation.METHODS: PC12 cells overexpressing Tyro-3 or Axl were established... | ['Animals', 'Blotting, Western', 'Cell Differentiation', 'Gene Expression', 'Gene Expression Regulation', 'Microscopy, Confocal', 'Nerve Growth Factor', 'Neurons', 'PC12 Cells', 'Proto-Oncogene Proteins', 'Rats', 'Receptor Protein-Tyrosine Kinases', 'Transfection'] | 21,270,900 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.152'], ['G05.297'], ['G05.308'], ['E01.370.350.515.395', 'E05.595.395'], ['D12.644.276.860.437', 'D12.776.467.860.437', 'D12.776.631.600.437', 'D23.529.850.437'], ['A08.675', 'A11.671'], ['A11.251.21... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The chronic hepatotoxicity assessment of the herbal formula Zishen Yutai pill. | Zishen Yutai pill (ZYP) is an oriental herbal formula, while hepatotoxicity assessment of ZYP was rarely evaluated. Therefore, our aim is to re-evaluate its hepatotoxicity in both normal and carbon tetrachloride (CCl4) induced chronic liver injury rats. In the normal model, two doses of ZYP (1.575 and 9.450 g kg-1 d-1;... | ['Administration, Oral', 'Alanine Transaminase', 'Animals', 'Biomarkers', 'Body Weight', 'Carbon Tetrachloride', 'Chemical and Drug Induced Liver Injury', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Drugs, Chinese Herbal', 'Eating', 'Female', 'Liver', 'Necrosis', 'Organ Size', 'Oxidative Stress', 'Ra... | 27,916,537 | [['E02.319.267.100'], ['D08.811.913.477.700.100'], ['B01.050'], ['D23.101'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D02.455.526.439.150'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Efficiency of silencing RNA for removal of transthyretin V30M in a TTR leptomeningeal animal model. | Some TTR mutants target the central nervous system (CNS). Familial amyloid polyneuropathy (FAP) with leptomeningeal involvement has been described in 9% of transthyretin (TTR) mutations and in valine for methionine at position 30 (V30M) patients. These individuals present dementia, ataxia, brain hemorrhages and focal n... | ['Amyloid Neuropathies, Familial', 'Animals', 'Brain', 'Cerebrovascular Circulation', 'Disease Models, Animal', 'Extracellular Matrix', 'Humans', 'Meninges', 'Mice', 'Mice, Transgenic', 'Mutation', 'Prealbumin', 'RNA Interference', 'RNA, Small Interfering'] | 27,884,058 | [['C10.574.500.050', 'C10.668.829.050.050', 'C16.320.400.050', 'C16.320.565.176.050', 'C18.452.648.176.050', 'C18.452.845.500.050.050', 'C18.452.845.500.075.050'], ['B01.050'], ['A08.186.211'], ['G09.330.100.159'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.284.295.310'], ['B01.050.150.900.649.313.988.400.112... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interleukin-18 is a novel mitogen of osteogenic and chondrogenic cells. | IL-18 was identified due to its ability to induce interferon-gamma (IFNgamma) production by T cells. It is a pleiotropic factor that shares structural features with IL-1 and functional activities with IL-12. IL-18 has a role in T cell development, where it has been demonstrated to act cooperatively with IL-12 to regula... | ['Animals', 'Cell Division', 'Cells, Cultured', 'Chondrocytes', 'Gene Expression', 'Granulocyte-Macrophage Colony-Stimulating Factor', 'Interferon-gamma', 'Interleukin-18', 'Mice', 'Mitogens', 'Organ Culture Techniques', 'Osteoclasts', 'Rats', 'Rats, Wistar'] | 12,639,900 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['A11.329.171'], ['G05.297'], ['D12.644.276.374.410.240.375', 'D12.776.395.240.300', 'D12.776.467.374.410.240.375', 'D23.529.374.410.240.375'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long-wavelength absorbing and fluorescent chameleon labels for proteins, peptides, and amines. | Long-wavelength absorbing labels that change their color and fluorescence upon conjugation to proteins and other biomolecules provide two critical advantages over the wealth of conventional amine-reactive labels. At first, the progress of the labeling reaction can be monitored continuously either visually or by spectro... | ['Amines', 'Animals', 'Fluorescent Dyes', 'Humans', 'Peptides', 'Proteins', 'Spectrometry, Fluorescence'] | 21,671,666 | [['D02.092'], ['B01.050'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644'], ['D12.776'], ['E05.196.712.516.600.676', 'E05.196.867.726']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immunodetection of gastrin-releasing peptide in malignant melanoma cells. | Gastrin-releasing peptide (GRP), the mammalian counterpart of bombesin, was first identified in the nervous system of the gastrointestinal tract. Little is known about its distribution in the human skin or about its function in certain diseases such as malignant melanoma. Recently functional GRP receptors have been fou... | ['Gastrin-Releasing Peptide', 'Humans', 'Immunoenzyme Techniques', 'Melanocytes', 'Melanoma', 'Neoplasm Invasiveness', 'Skin', 'Skin Neoplasms'] | 10,985,675 | [['D06.472.317.410', 'D12.644.400.315', 'D12.776.631.650.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['A11.409.750', 'A11.436.613'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['C04.697.645', 'C23.550.727.645'], ['A17... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
First experience of carbon-ion radiotherapy for early breast cancer. | Breast cancer is increasingly being detected at earlier stages, and partial breast irradiation for patients with low-risk-group tumor has come to be applied in the US and Europe as an alternative to whole-breast irradiation. Based on those experiences, some institutes have tried using particle beams for partial breast ... | ['Breast Neoplasms', 'Carbon', 'Contrast Media', 'Dose Fractionation, Radiation', 'Female', 'Heavy Ion Radiotherapy', 'Humans', 'Magnetic Resonance Imaging', 'Middle Aged', 'Neoplasm Staging', 'Positron-Emission Tomography', 'Radiotherapy Dosage', 'Tomography, X-Ray Computed'] | 24,615,166 | [['C04.588.180', 'C17.800.090.500'], ['D01.268.150'], ['D27.505.259.500', 'D27.720.259'], ['E02.815.639.200'], ['E02.815.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E01.789.625'], ['E01.370.350.350.800.700', 'E01.370.350.600.350.800.399', 'E01.370.350.710.800.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Metacognitive control and strategy selection: deciding to practice retrieval during learning. | Retrieval practice is a potent technique for enhancing learning, but how often do students practice retrieval when they regulate their own learning? In 4 experiments the subjects learned foreign-language items across multiple study and test periods. When items were assigned to be repeatedly tested, repeatedly studied, ... | ['Cognition', 'Decision Making', 'Humans', 'Language', 'Learning', 'Mental Recall', 'Practice, Psychological', 'Reading', 'Retention, Psychology', 'Students'] | 19,883,131 | [['F02.463.188'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['F02.463.425', 'F02.784.629.529'], ['F02.463.425.540.641'], ['F02.463.425.674'], ['L01.559.423.557'], ['F02.463.425.540.772'], ['M01.848']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Appendicectomy: an assessment of the advisability of stump invagination. | Seven hundred and thirty-two cases of appendicectomy performed over a period of 5 years are reviewed to compare the incidence of complications and the length of the postoperative stay in hospital, depending on whether the appendix stump was simply ligated or was invaginated by purse string suture following ligation. No... | ['Adult', 'Appendectomy', 'Female', 'Humans', 'Length of Stay'] | 922,311 | [['M01.060.116'], ['E04.210.078'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Suppression of herpes simplex virus type 1 reactivation from latency by (+-)-9-([(Z)-2-(hydroxymethyl)cyclohexyl]methyl) guanine (L-653,180) in vitro. | Latent herpes simplex virus type 1 (HSV-1) infection was induced in human embryonic lung cells in vitro by using a combination of viral replication inhibitors and elevated temperature. Under reactivating conditions (superinfection by human cytomegalovirus or temperature manipulation), a nonantiviral thymidine kinase in... | ['Antiviral Agents', 'Cells, Cultured', 'Female', 'Guanine', 'Humans', 'Pregnancy', 'Simplexvirus', 'Superinfection', 'Virus Activation', 'Virus Replication'] | 2,171,423 | [['D27.505.954.122.388'], ['A11.251'], ['D03.633.100.759.758.399.454'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['B04.280.382.100.750'], ['C01.597.880', 'C01.610.684.880', 'C01.925.597.880'], ['G06.920.925.940'], ['G06.920.925']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Methods to improve the detection of mild cognitive impairment. | We examined whether the performance of the National Institute of Aging's Consortium to Establish a Registry for Alzheimer's Disease's 10-word list (CWL), part of the consortium's neuropsychological battery, can be improved for detecting Alzheimer's disease and related disorders early. We focused on mild cognitive impai... | ['Aged', 'Alzheimer Disease', 'Case-Control Studies', 'Cognition Disorders', 'Data Interpretation, Statistical', 'Diagnosis, Differential', 'Female', 'Humans', 'Logistic Models', 'Male', 'Mental Recall', 'Middle Aged', 'Neuropsychological Tests', 'ROC Curve', 'Sensitivity and Specificity', 'Severity of Illness Index', ... | 15,781,874 | [['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['F03.615.250'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['E01.171'], ['B01.050.150.900... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Transcriptome map of mouse isochores in embryonic and neonatal cortex. | Several studies on adult tissues agree on the presence of a positive effect of the genomic and genic base composition on mammalian gene expression. Recent literature supports the idea that during developmental processes GC-poor genomic regions are preferentially implicated. We investigate the relationship between the c... | ['Animals', 'Base Composition', 'Brain', 'Chromosome Mapping', 'Embryo, Mammalian', 'Gene Expression Regulation, Developmental', 'Gene Library', 'Isochores', 'Mice', 'Sequence Analysis, RNA', 'Transcriptome'] | 23,195,409 | [['B01.050'], ['G02.111.080'], ['A08.186.211'], ['E05.393.183'], ['A16.254'], ['G05.308.310'], ['G05.360.325'], ['D13.444.308.580', 'G05.360.340.024.430'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.393.760.710'], ['G02.111.873.750', 'G05.297.700.750', 'G05.360.920']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structural characterization of the N-terminal mineral modification domains from the molluscan crystal-modulating biomineralization proteins, AP7 and AP24. | The AP7 and AP24 proteins represent a class of mineral-interaction polypeptides that are found in the aragonite-containing nacre layer of mollusk shell (H. rufescens). These proteins have been shown to preferentially interfere with calcium carbonate mineral growth in vitro. It is believed that both proteins play an imp... | ['Amino Acid Sequence', 'Animals', 'Calcification, Physiologic', 'Calcium Carbonate', 'Magnetic Resonance Spectroscopy', 'Models, Molecular', 'Molecular Sequence Data', 'Mollusca', 'Peptides', 'Protein Binding', 'Protein Structure, Tertiary', 'Proteins'] | 15,222,016 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G07.345.155.500', 'G07.345.500.325.377.625.050.500.175', 'G11.427.578.050.500.175'], ['D01.146.275', 'D01.200.275.150.150', 'D01.578.200'], ['E05.196.867.519'], ['E05.599.595'], ['L01.453.245.667'], ['B01.050.500.644'], ['D12.644'], ['G02.111.679', 'G03.808'],... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Who lies? | Seventy-seven undergraduates and 70 demographically diverse members of the community completed 12 individual differences measures hypothesized to predict lie-telling in everyday life and then kept a diary every day for a week of all of their social interactions and all of the lies that they told during those interactio... | ['Adolescent', 'Adult', 'Age Factors', 'Deception', 'Female', 'Humans', 'Interpersonal Relations', 'Machiavellianism', 'Male', 'Personality', 'Personality Assessment', 'Socialization'] | 8,656,334 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.145.813.157'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F01.752.650'], ['F01.752'], ['F04.513'], ['I01.880.853.934']] | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Comparative analysis of clinical and laboratory methods for diagnosing streptococcal sore throat]. | OBJECTIVES: Diagnosis and correct treatment of group A streptococcal sore throat is important particularly to prevent non-suppurative sequelae. Clinical findings continue to be used to differentiate streptococcal infection from viral sore throat. The American Academy of Pediatrics recommends that streptococcal sore thr... | ['Adolescent', 'Bacterial Typing Techniques', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Likelihood Functions', 'Male', 'Pharyngitis', 'Predictive Value of Tests', 'Prospective Studies', 'Reagent Kits, Diagnostic', 'Sensitivity and Specificity', 'Streptococcal Infections', 'Streptococcus pyogenes', 'Tonsillitis'... | 15,742,082 | [['M01.060.057'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.830.500.475', 'N06.850.520.830... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Association of occlusal interference-induced masseter muscle hyperalgesia and P2X3 receptors in the trigeminal subnucleus caudalis and midbrain periaqueductal gray. | P2X3 receptor plays a role in nociception transmission of orofacial pain in temporomandibular disorder patients. A previous study found that P2X3 receptors in masseter muscle afferent neurons and the trigeminal ganglia were involved in masseter muscle pain induced by inflammation caused by chemical agents or eccentric ... | ['Animals', 'Disease Models, Animal', 'Facial Pain', 'Hyperalgesia', 'Immunohistochemistry', 'Male', 'Masseter Muscle', 'Pain Threshold', 'Periaqueductal Gray', 'Polymerase Chain Reaction', 'RNA, Messenger', 'Random Allocation', 'Rats, Wistar', 'Receptors, Purinergic P2X3', 'Tooth', 'Touch', 'Trigeminal Nuclei'] | 26,836,462 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.888.592.612.330'], ['C10.597.751.791.400', 'C23.888.592.763.770.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Synthesis, receptor binding and biodistribution of the gem-21-chloro-21-iodovinylestradiol derivatives. | Radioiodinated 11 beta-methoxy-(17 alpha,20E)iodovinylestradiol (11 beta-OMe-IVE2) shows high estrogen receptor (ER)-mediated uterus uptake and good potential as an ER-imaging agent. In order to examine the tolerance of the ER for modification about the iodovinyl substituent, we prepared the (17 alpha,20Z-chloro)21-chl... | ['Animals', 'Estradiol', 'Female', 'Rats', 'Receptors, Estrogen', 'Tissue Distribution', 'Uterus'] | 8,240,984 | [['B01.050'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.826.750.350', 'D12.776.930.778.350'], ['G03.787.917', 'G07.690.725.949'], ['A05.360.319.679']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
When and how to operate the posterior malleolus fragment in trimalleolar fractures: a systematic literature review. | OBJECTIVES: Whether or not and how to fixate the posterior malleolus fracture seems to depend on the fracture fragment size and its amount of dislocation, but clear guidelines for daily practice are lacking. In this review, we summarize the literature on preferred treatment of the posterior fragment in trimalleolar fra... | ['Ankle Fractures', 'Fracture Fixation, Internal', 'Humans', 'Tibia', 'Tibial Fractures', 'Treatment Outcome'] | 29,752,537 | [['C26.404.014'], ['E04.555.300.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.043.650.883'], ['C26.404.875', 'C26.558.857'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Diffusion-weighted imaging characteristics of biopsy-proven demyelinating brain lesions. | OBJECTIVES: To describe lesional diffusion-weighted imaging characteristics in a cohort of patients with biopsy-proven CNS inflammatory demyelinating disease (IDD) and compare diffusion characteristics of ring-enhancing CNS IDD lesions vs abscesses and tumors.METHODS: Forty prebiopsy apparent diffusion coefficient (ADC... | ['Abscess', 'Adolescent', 'Adult', 'Aged', 'Cohort Studies', 'Demyelinating Diseases', 'Diffusion Magnetic Resonance Imaging', 'Female', 'Humans', 'Inflammation', 'Male', 'Middle Aged', 'Neoplasms', 'Retrospective Studies', 'Single-Blind Method', 'Young Adult'] | 22,573,639 | [['C01.830.025', 'C23.550.470.756.100'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C10.314'], ['E01.370.350.825.500.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['M01.060.116.630'], ['C04'], ['E05.3... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An in vitro physiological study of normal and unstable human detrusor muscle. | A systematic in vitro physiological study of isolated human detrusor muscle strips is reported. Detrusor strips were obtained at operation. Pre-operative urodynamic studies enabled specimens to be classified as normal or unstable. Comparisons were made between responses of normal and unstable detrusor strips. The resul... | ['Acetylcholine', 'Adult', 'Aged', 'Clonidine', 'Electric Stimulation', 'Female', 'Humans', 'In Vitro Techniques', 'Isoproterenol', 'Male', 'Middle Aged', 'Muscle Contraction', 'Muscle, Smooth', 'Phentolamine', 'Receptors, Adrenergic, alpha', 'Urinary Bladder'] | 6,295,541 | [['D02.092.211.111'], ['M01.060.116'], ['M01.060.116.100'], ['D03.383.129.308.436.500'], ['E05.723.402'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559.389.657.166.175.649'], ['M01.060.116.630'], ['G11.427.494'], ['A02.63... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The structure of an alternative wall teichoic acid produced by a Lactobacillus plantarum WCFS1 mutant contains a 1,5-linked poly(ribitol phosphate) backbone with 2-á-D-glucosyl substitutions. | A tagF1-tagF2 deletion mutant of Lactobacillus plantarum lacks poly(glycerol phosphate) polymerase activity required for glycerol-type wall teichoic acid (WTA) biosynthesis. The mutant activates an alternative genetic locus, tarIJKL, encoding the enzymes for nucleotide activation and incorporation of ribitol in the WTA... | ['Cell Wall', 'Glucose', 'Lactobacillus plantarum', 'Mutation', 'Polysaccharides', 'Teichoic Acids'] | 23,454,138 | [['A11.284.183'], ['D09.947.875.359.448'], ['B03.353.750.450.475.612', 'B03.510.460.400.410.475.475.612', 'B03.510.550.450.475.612'], ['G05.365.590'], ['D09.698'], ['D09.408.872', 'D09.698.718.825', 'D09.894.847', 'D23.050.161.616.797']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inositol 1,3,4,5-tetrakisphosphate and inositol 1,4,5-trisphosphate act by different mechanisms when controlling Ca2+ in mouse lacrimal acinar cells. | In internally perfused single lacrimal acinar cells the competitive inositol 1,4,5-trisphosphate (Ins 1,4,5-P3)-antagonist heparin inhibits the ACh-evoked K+ current response mediated by internal Ca2+ and also blocks both the Ins 1,4,5-P3-evoked transient as well as the sustained K+ current increase evoked by combined ... | ['Acetylcholine', 'Animals', 'Calcium', 'Heparin', 'Inositol 1,4,5-Trisphosphate', 'Inositol Phosphates', 'Lacrimal Apparatus', 'Mice', 'Potassium Channels', 'Sugar Phosphates'] | 2,535,675 | [['D02.092.211.111'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D09.698.373.400'], ['D02.033.800.519.400.350', 'D09.853.519.400.350', 'D09.894.480.350'], ['D02.033.800.519.400', 'D09.853.519.400', 'D09.894.480'], ['A09.371.463', 'A10.336.422'], ['B01.050.150.900.649.313.992.635.505.500'], ['... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Anthrenus dermatitis]. | A 31-year-old male presented with widespread itchy papules, especially on the legs, which had appeared 4 weeks previously. He reported that his wife and both daughters had developed similar lesions during the last week. Numerous small beetle larvae had been detected in his apartment, which were identified as museum bee... | ['Adult', 'Animals', 'Coleoptera', 'Dermatitis, Allergic Contact', 'Humans', 'Intradermal Tests', 'Larva', 'Male', 'Pruritus', 'Skin', 'Urticaria'] | 12,063,744 | [['M01.060.116'], ['B01.050'], ['B01.050.500.131.617.720.500.500.375'], ['C17.800.174.255.100', 'C17.800.815.255.100', 'C20.543.418.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812.871.300', 'E05.200.812.871.300', 'E05.478.594.890.300'], ['B05.500.500', 'G07.345.500.550.500.500'], ['C17.800.685... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression. | PURPOSE: In this study, we examined the role of peroxiredoxin I (Prx I) in lung cancer cell growth in vitro and in vivo and its influence on these tumor cells' sensitivity to radiotherapy.METHODS AND MATERIALS: We established stable transfectants of A549 (p53+) and H1299 (p53-) lung carcinoma cell lines with Prx I anti... | ['Animals', 'Cell Line, Tumor', 'DNA Damage', 'Down-Regulation', 'Humans', 'Lung Neoplasms', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Neoplasm Proteins', 'Oligonucleotides, Antisense', 'Peroxidases', 'Peroxiredoxins', 'Proto-Oncogene Proteins c-bcl-2', 'Radiation Tolerance', 'Reactive Oxygen Species', 'Transfectio... | 16,414,373 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['G05.200'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phocine distemper virus in seals, east coast, United States, 2006. | In 2006 and 2007, elevated numbers of deaths among seals, constituting an unusual mortality event, occurred off the coasts of Maine and Massachusetts, United States. We isolated a virus from seal tissue and confirmed it as phocine distemper virus (PDV). We compared the viral hemagglutinin, phosphoprotein, and fusion (F... | ['Amino Acid Sequence', 'Animals', 'Chlorocebus aethiops', 'Distemper', 'Distemper Virus, Phocine', 'Maine', 'Massachusetts', 'Molecular Sequence Data', 'Mutation', 'Phoca', 'RNA, Viral', 'Sequence Alignment', 'Sequence Analysis, DNA', 'United States', 'Vero Cells', 'Viral Proteins'] | 21,291,591 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['C01.925.782.580.600.500.285', 'C22.268.265'], ['B04.820.480.937.600.650.500.320'], ['Z01.107.567.875.550.500'], ['Z01.107.567.875.550.510'], ['L01.453.245.667'], ['G05.365.590'], ['B01.050.150.900.649.31... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Decreased diversity but increased substitution rate in host mtDNA as a consequence of Wolbachia endosymbiont infection. | A substantial fraction of insects and other terrestrial arthropods are infected with parasitic, maternally transmitted endosymbiotic bacteria that manipulate host reproduction. In addition to imposing direct selection on the host to resist these effects, endosymbionts may also have indirect effects on the evolution of ... | ['Animals', 'DNA, Mitochondrial', 'Drosophila', 'Evolution, Molecular', 'Genetic Variation', 'Mitochondria', 'Molecular Sequence Data', 'Wolbachia'] | 15,611,174 | [['B01.050'], ['D13.444.308.283.225'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['G05.045.250', 'G16.075.250'], ['G05.365'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['L01.453.245.667'], ['B03.660.050.783.500.762']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Non-invasive monitoring of subclinical and clinical actinic keratosis of face and scalp under topical treatment with ingenol mebutate gel 150 mcg/g by means of reflectance confocal microscopy and optical coherence tomography: New perspectives and comparison of diagnostic techniques. | Actinic keratosis (AK) corresponds to the earliest stage of in situ squamous cell carcinoma and arises on chronically sun-exposed skin. Around the clinically evident AKs, the apparently healthy epidermis may contain different grades of atypia that can be detected by noninvasive imaging techniques such as reflectance co... | ['Administration, Topical', 'Aged', 'Aged, 80 and over', 'Diterpenes', 'Dose-Response Relationship, Drug', 'Face', 'Female', 'Humans', 'Keratosis, Actinic', 'Male', 'Microscopy, Confocal', 'Scalp', 'Tomography, Optical Coherence'] | 30,653,833 | [['E02.319.267.120'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D02.455.849.291'], ['G07.690.773.875', 'G07.690.936.500'], ['A01.456.505'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.834.450', 'C17.800.428.570'], ['E01.370.350.515.395', 'E05.595.395'], ['A01.456.810'], ['E01.370.350.589.249.500', 'E01... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Characterization of the interaction between Oidium heveae and Arabidopsis thaliana. | Oidium heveae, an obligate biotrophic pathogen of rubber trees (Hevea brasiliensis), causes significant yield losses of rubber worldwide. However, the molecular mechanisms underlying the interplay between O. heveae and rubber trees remain largely unknown. In this study, we isolated an O. heveae strain, named HN1106, fr... | ['Arabidopsis', 'Arabidopsis Proteins', 'Ascomycota', 'Cell Death', 'Disease Resistance', 'Ecotype', 'Host-Pathogen Interactions', 'Hyphae', 'Phenotype', 'Plant Diseases', 'Plant Leaves', 'Salicylic Acid'] | 26,724,785 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['B01.300.107'], ['G04.146'], ['C23.550.291.671', 'G12.450.564.250', 'G12.450.800.250', 'G15.630.250'], ['G05.695.200', 'G16.500.275.157.049.230', 'N06.230.124.049.230'], ['G06.462', 'G16.527.200'], ['A19.687.400'], ['G05.695'], ['G15.610'], ['A18.024.812']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Glycosaminoglycan production by bovine aortic endothelial cells cultured in sulfate-depleted medium. | Bovine aortic endothelial cells were cultured in medium containing [3H]glucosamine and concentrations of [35S]sulfate ranging from 0.01 to 0.31 mM. While the amount of [3H]hexosamine incorporated into chondroitin sulfate and heparan sulfate was constant, decreasing concentrations of sulfate resulted in lower [35S]sulfa... | ['Animals', 'Aorta', 'Cattle', 'Cells, Cultured', 'Chondroitin Sulfates', 'Chromatography, DEAE-Cellulose', 'Endothelium', 'Glucosamine', 'Glycosaminoglycans', 'Heparitin Sulfate', 'Hexosamines', 'Sulfates'] | 3,087,988 | [['B01.050'], ['A07.015.114.056'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['D09.698.373.200.300'], ['E05.196.181.400.383.349'], ['A10.272.491'], ['D09.067.342.531'], ['D09.698.373'], ['D09.698.373.425'], ['D09.067.342'], ['D01.248.497.158.845', 'D01.875.800.800.850']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Modelling the spatio-temporal evolution of 3H in the waters of the River Tagus. | Measurements of tritium specific activity levels and of temperatures in waters of the Torrej?n-Tagus reservoir (Spain) showed that their radioactive characteristics were basically influenced by the radioactive liquid effluent from the Almaraz Nuclear Power Plant. This enters the Torrej?n-Tagus reservoir via the Arrocam... | ['Environmental Monitoring', 'Mathematics', 'Numerical Analysis, Computer-Assisted', 'Power Plants', 'Rivers', 'Spain', 'Temperature', 'Time Factors', 'Tritium', 'Water Pollutants, Radioactive'] | 16,360,243 | [['N06.850.460.350.080', 'N06.850.780.375'], ['H01.548'], ['L01.224.680.700'], ['J01.780', 'J03.540.680'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['Z01.542.846'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.910.857'], ['D01.2... | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 |
The effect of melatonin on oxidative stress and apoptosis in experimental diabetes mellitus-related ovarian injury. | We aimed to evaluate the effect of melatonin on oxidative stress and ovarian injury in rats. Twenty-four Sprague-Dawley albino rats were divided into three groups: Group 1 as nondiabetic healthy controls (n = 8), group 2 as nontreated diabetic rats (n = 8) and group 3 as melatonin-treated diabetic rats (n = 8). After o... | ['Animals', 'Apoptosis', 'Caspase 3', 'Diabetes Mellitus, Experimental', 'Female', 'Melatonin', 'NF-kappa B', 'Ovary', 'Oxidative Stress', 'Rats', 'Rats, Sprague-Dawley'] | 26,743,008 | [['B01.050'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['D03.633.100.473.914.481', 'D06.472.506'], ['D05.500.672', 'D12.776.260.600', 'D12.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA. | In order to directly detect nucleic acid polymers, we have designed biosensors comprising sequence-specific DNA binding proteins tethered to split-reporter proteins, which generate signal upon binding a predetermined nucleic acid target, in an approach termed SEquence-Enabled Reassembly (SEER). Herein we demonstrate th... | ['DNA', 'DNA Methylation', 'DNA-Binding Proteins', 'Fluorescent Dyes', 'Humans', 'Luminescent Proteins', 'Spectrometry, Fluorescence', 'Zinc Fingers'] | 19,457,665 | [['D13.444.308'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D12.776.260'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.532'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['G02.111.570.820.709.275.500.985']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Radiographic findings and hypotensive reactions in excretory urography. | The radiographic findings and the hypotension patterns were reviewed in 19 patients having hypotensive reactions in routine excretory urography using ionic contrast medium. The lowest systolic blood pressure was above 80 mmHg in 10 patients while below 80 mmHg in remaining 9 patients. The urogram was unremarkable as lo... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Contrast Media', 'Female', 'Humans', 'Hypotension', 'Male', 'Middle Aged', 'Urography'] | 2,602,098 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.259.500', 'D27.720.259'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.514'], ['M01.060.116.630'], ['E01.370.350.700.830', 'E01.370.390.830']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The consequences of a week of insomnia. | A yoked control study used sleep recordings from 10 insomniacs to produce similar sleep patterns in a group of matched normal sleepers for 7 nights to determine if specific electroencephalographic (EEG) sleep patterns were responsible for the secondary insomnia symptoms reported by the insomniacs. Specifically, it was ... | ['Adult', 'Analysis of Variance', 'Female', 'Humans', 'Male', 'Middle Aged', 'Polysomnography', 'Psychomotor Performance', 'Sleep', 'Sleep Initiation and Maintenance Disorders', 'Time Factors'] | 8,865,501 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.520.625'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['F02.830.855', 'G11.561.803'], ['C10.886.425.800.800', 'F03.870.400.800.800'], ['G01.910.857']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Differential diagnosis of acute myocardial infarct in hypothyroidism]. | The authors demonstrate the case of a female patient with hypothyroid myopathy where they recorded repeatedly a rise of enzymes used for the diagnosis of acute myocardial infarction, whereby myocardial infarction was not revealed. The authors followed up the disease for two years. They evaluated the relationship betwee... | ['Aged', 'Clinical Enzyme Tests', 'Female', 'Humans', 'Hypothyroidism', 'Myocardial Infarction'] | 2,633,457 | [['M01.060.116.100'], ['E01.370.225.124.200', 'E05.196.427.200', 'E05.200.124.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.874.482'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A novel carrier for Phanerochaete chrysosporium immobilization. | Phanerochaete chrysosporium BKMF-1767 cells were immobilized on different carriers. The optimum carrier according to adsorbed P. chrysosporium cells number (86.38%) was determined to be polystyrene foam, a novel carrier. The conditions for the immobilization of cells on polystyrene foam were optimized and determined as... | ['Bioreactors', 'Cells, Immobilized', 'Fungal Proteins', 'Peroxidases', 'Phanerochaete', 'Plastics'] | 15,974,183 | [['E07.115', 'J01.897.120.115'], ['A11.270'], ['D12.776.354'], ['D08.811.682.732'], ['B01.300.179.120.570'], ['D05.750.716', 'D25.720.716', 'J01.637.051.720.716']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Flemingin-Type Prenylated Chalcones from the Sarawak Rainforest Plant Desmodium congestum. | In an ongoing program to identify new anti-infective leads, an extract derived from whole plant material of Desmodium congestum collected in the Sarawak rainforest was found to have anti-MRSA activity. Bioassay-guided isolation led to the isolation of two new prenylated chalcones, 5'-O-methyl-3-hydroxyflemingin A (1) a... | ['Chalcones', 'Fabaceae', 'Gram-Positive Bacteria', 'HEK293 Cells', 'Humans', 'Malaysia', 'Methicillin-Resistant Staphylococcus aureus', 'Microbial Sensitivity Tests', 'Molecular Structure', 'Nuclear Magnetic Resonance, Biomolecular', 'Prenylation', 'Rainforest'] | 26,284,978 | [['D02.522.818.222', 'D03.383.663.283.266.450.221', 'D03.633.100.150.266.450.221'], ['B01.650.940.800.575.912.250.401'], ['B03.510'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.145.487'], ['B03.300.390.400.800.750.100.500', 'B03.353.500.750.750.100.500', 'B03.510.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Expression of p53 in oesophageal squamous epithelium from surgical specimens resected for squamous cell carcinoma of the oesophagus, with special reference to uninvolved mucosa. | Accumulation of p53 protein has been considered an intermediate biomarker in multistage oesophageal carcinogenesis. The aim of the present study was to investigate p53 expression by immunohistochemistry in 13 thoroughly sampled oesophagectomy specimens from a geographical area with a high oesophageal cancer incidence (... | ['Carcinoma in Situ', 'Carcinoma, Squamous Cell', 'Chronic Disease', 'Esophageal Neoplasms', 'Esophagitis', 'Humans', 'Immunoenzyme Techniques', 'Mucous Membrane', 'Neoplasm Invasiveness', 'Precancerous Conditions', 'Tumor Suppressor Protein p53'] | 9,120,718 | [['C04.557.470.200.240'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C23.550.291.500'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['C06.405.117.620', 'C06.405.205.663'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.40... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program. | During endochondral ossification, small, immature chondrocytes enlarge to form hypertrophic chondrocytes, which express collagen X. In this work, we demonstrate that FoxA factors are induced during chondrogenesis, bind to conserved binding sites in the collagen X enhancer, and can promote the expression of a collagen X... | ['Alkaline Phosphatase', 'Animals', 'Binding Sites', 'Cell Differentiation', 'Cell Enlargement', 'Cells, Cultured', 'Chick Embryo', 'Chondrocytes', 'Chondrogenesis', 'Collagen Type X', 'Core Binding Factor Alpha 1 Subunit', 'Dwarfism', 'Embryo, Mammalian', 'Fibroblasts', 'Genes, Reporter', 'Growth Plate', 'Hepatocyte N... | 22,595,668 | [['D08.811.277.352.650.035'], ['B01.050'], ['G02.111.570.120'], ['G04.152'], ['G04.161.500', 'G07.345.249.410.500'], ['A11.251'], ['A13.350.150', 'A16.331.200'], ['A11.329.171'], ['G07.345.500.325.377.625.180', 'G11.427.578.180'], ['D12.776.860.300.250.400.500'], ['D12.776.930.155.200.100'], ['C05.116.099.343', 'C16.32... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Remote control of diastereoselectivity in intramolecular reactions of chiral allylsilanes. | During investigations of cyclization reactions between chiral allylsilanes and N-acyliminium ions, it was discovered that a suitably positioned benzyloxy group on the allylsilane component caused a reversal in the diastereoselectivity of these reactions relative to that normally observed with alkyl-substituted allylsil... | ['Acylation', 'Alkenes', 'Alkylation', 'Cations', 'Cyclization', 'Imines', 'Ions', 'Magnetic Resonance Spectroscopy', 'Models, Chemical', 'Silanes', 'Stereoisomerism', 'Thermodynamics'] | 17,044,701 | [['G02.111.012', 'G02.607.063', 'G03.040'], ['D02.455.326.271'], ['G02.111.035', 'G02.607.094', 'G03.059'], ['D01.248.497.300'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['D02.491'], ['D01.248.497'], ['E05.196.867.519'], ['E05.599.495'], ['D01.837.700'], ['G02.607.445.682'], ['G01.906']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
IFN-ã-mediated efficacy of allergen-free immunotherapy using mycobacterial antigens and CpG-ODN. | Epidemiological and experimental evidence supports the notion that microbial infections that are known to induce Th1-type immune responses can suppress Th2 immune responses, which are characteristics of allergic disorders. However, live microbial immunization might not be feasible for human immunotherapy. Here, we eval... | ['Adoptive Transfer', 'Animals', 'Antigens, Bacterial', 'Bronchoalveolar Lavage Fluid', 'Cytokines', 'Eosinophilia', 'Female', 'Hypersensitivity', 'Immunoglobulin E', 'Immunoglobulin G', 'Immunotherapy', 'Interferon-gamma', 'Interleukin-10', 'Lung Diseases', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Mice, K... | 21,403,663 | [['E02.095.465.425.400.330.050', 'E05.478.550.520.050'], ['B01.050'], ['D23.050.161'], ['E05.927.100.500'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C15.378.553.231'], ['C20.543'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D12.776.377.715.548.114.619.312'], ['D12.776.124.48... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long-term biological consequences of nuclear war. | Subfreezing temperatures, low light levels, and high doses of ionizing and ultraviolet radiation extending for many months after a large-scale nuclear war could destroy the biological support systems of civilization, at least in the Northern Hemisphere. Productivity in natural and agricultural ecosystems could be sever... | ['Animals', 'Atmosphere', 'Climate', 'Environment', 'Humans', 'Nuclear Warfare', 'Photosynthesis', 'Radiation, Ionizing', 'Radioactive Fallout', 'Sunlight', 'Temperature', 'Ultraviolet Rays'] | 6,658,451 | [['B01.050'], ['G16.500.275.063', 'N06.230.300.100'], ['G16.500.275.071', 'N06.230.300.100.250'], ['G16.500.275', 'N06.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.735.950.500.600'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.700', 'G03.800.700', 'G15.568'], ['G01... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Proximal cervical spinal nerve: MR appearance. | An interradicular cleft and a segment of nerve containing fascicles have recently been described in the cervical spinal nerve. This study was performed to determine whether the fascicles and the interradicular cleft have a distinctive appearance on magnetic resonance (MR) images. The proximal spinal nerves and nerve ro... | ['Aged', 'Aged, 80 and over', 'Female', 'Humans', 'In Vitro Techniques', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Spinal Nerve Roots', 'Spinal Nerves'] | 1,620,837 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['A08.800.800.720.725'], ['A08.800.800.720']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Diagnostic delay in a case of T-cell neurolymphomatosis. | A 69-year-old woman presented with severe subacute painful meningoradiculoneuritis. Neurophysiology showed a patchy, proximal axonal process with widespread denervation. Cerebrospinal fluid (CSF) was lymphocytic (normal T-cell predominant) with negative cytology. MRI revealed multiple sites of enhancement, but fluorode... | ['Administration, Intravenous', 'Adrenal Cortex Hormones', 'Aged', 'Bone Marrow', 'Brachial Plexus', 'Cerebrospinal Fluid', 'Cyclosporine', 'Delayed Diagnosis', 'Diagnosis, Differential', 'Fatal Outcome', 'Female', 'Fluorodeoxyglucose F18', 'Gene Rearrangement, T-Lymphocyte', 'Humans', 'Immunosuppressive Agents', 'Magn... | 31,888,900 | [['E02.319.267.082'], ['D06.472.040'], ['M01.060.116.100'], ['A15.382.216'], ['A08.800.800.720.050'], ['A12.207.270.210'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['E01.110', 'E02.760.273', 'N02.421.585.273'], ['E01.171'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.85... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of particle size and partial replacement of alfalfa hay by soya bean hulls on nutrient intake, total tract digestibility and rumen degradability of diets by Holstein steers. | This study examined the effect of alfalfa hay (AH) particle size and the replacement of soya bean hull (SH) for AH within the diet of restricted fed Holstein steers on dry matter intake (DMI), total tract digestion, ruminal digestion, ruminal pH and ammonia nitrogen content, and faecal pH. Four rumen-cannulated Holstei... | ['Animal Feed', 'Animals', 'Cattle', 'Diet', 'Digestion', 'Feeding Behavior', 'Food Handling', 'Male', 'Medicago sativa', 'Rumen', 'Soybeans'] | 27,859,733 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G07.203.650.240'], ['G07.203.650.250', 'G10.261.190'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['J01.576.423.200'], ['B01.650.940.800.575.912.250.401.590.500'], ['A13.869.804'], ['B01.650.940.800.575.912.... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The dual functions of WLIM1a in cell elongation and secondary wall formation in developing cotton fibers. | LIN-11, Isl1 and MEC-3 (LIM)-domain proteins play pivotal roles in a variety of cellular processes in animals, but plant LIM functions remain largely unexplored. Here, we demonstrate dual roles of the WLIM1a gene in fiber development in upland cotton (Gossypium hirsutum). WLIM1a is preferentially expressed during the e... | ['Actins', 'Cell Nucleus', 'Cell Wall', 'Cloning, Molecular', 'Cotton Fiber', 'Cytoplasm', 'Gene Expression Regulation, Plant', 'Gossypium', 'Hydrogen Peroxide', 'Lignin', 'Phylogeny', 'Plant Cells', 'Plant Proteins', 'Plants, Genetically Modified', 'Protein Transport'] | 24,220,634 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.183'], ['E05.393.220'], ['J01.637.836.299'], ['A11.284.430.214'], ['G05.308.375'], ['B01.650.940.800.575.912.250.859.821.500.244'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424',... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Antibiotic prescribing for children. Too much and too little? Retrospective observational study in primary care. | AIMS: To investigate the extent of dose-related off-label antibiotic paediatric prescribing in primary care and to identify any potential clinical effects, particularly of lower than recommended dose prescribing.METHODS: Assessment of antibiotic prescribing in 168 396 children aged 0-16 years for the year 1999-2000 fro... | ['Adolescent', 'Anti-Bacterial Agents', 'Child', 'Child, Preschool', 'Drug Prescriptions', 'Family Practice', 'Humans', 'Infant', 'Infant, Newborn', "Practice Patterns, Physicians'", 'Retrospective Studies', 'Scotland'] | 12,848,780 | [['M01.060.057'], ['D27.505.954.122.085'], ['M01.060.406'], ['M01.060.406.448'], ['E02.319.307', 'N02.421.668.778.500'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['N04.590.374.577', 'N05.300.625'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Hippocampal neurogenesis of Wistar Kyoto rats is congenitally impaired and correlated with stress resistance. | The hippocampus is thought to be an important region for depression. However, the relationship between hippocampal neurogenesis and depression is still controversial. Wistar Kyoto (WKY) rats are frequently used as a depression model. WKY rats are known to show physiologically abnormal features, and these features resem... | ['Animals', 'Bromodeoxyuridine', 'Cell Count', 'Cell Proliferation', 'Depression', 'Disease Models, Animal', 'Exploratory Behavior', 'Hippocampus', 'Lateral Ventricles', 'Microtubule-Associated Proteins', 'Neurogenesis', 'Neurons', 'Neuropeptides', 'Rats', 'Rats, Inbred WKY', 'Rats, Wistar', 'Statistics as Topic', 'Suc... | 28,465,137 | [['B01.050'], ['D03.383.742.680.852.300.150', 'D13.570.230.430.196', 'D13.570.685.852.300.150'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.161.750', 'G07.345.249.410.750'], ['F01.145.126.350'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['F01.145.387', 'F01.658.370'], ['A08.186.211... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenom... | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Alterations in perivascular innervation function in mesenteric arteries from offspring of diabetic rats. | BACKGROUND AND PURPOSE: We have reported that exposure to a diabetic intrauterine environment during pregnancy increases blood pressure in adult offspring, but the mechanisms involved are not completely understood. This study was designed to analyse a possible role of perivascular sympathetic and nitrergic innervation ... | ['Acetylcholine', 'Adenosine Triphosphate', 'Animals', 'Blood Glucose', 'Blood Pressure', 'Body Weight', 'Diabetes Mellitus, Experimental', 'Electric Stimulation', 'Female', 'Male', 'Mesenteric Arteries', 'Nitric Oxide', 'Nitric Oxide Synthase Type I', 'Pregnancy', 'Rats, Wistar', 'Sodium', 'Superoxides', 'Vasoconstric... | 26,177,571 | [['D02.092.211.111'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D09.947.875.359.448.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C18.452.394.75... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Physical Characterization of Tobramycin Inhalation Powder: II. State Diagram of an Amorphous Engineered Particle Formulation. | Tobramycin Inhalation Powder (TIP) is a spray-dried engineered particle formulation used in TOBI Podhaler, a drug-device combination for treatment of cystic fibrosis (CF). A TIP particle consists of two phases: amorphous, glassy tobramycin sulfate and a gel-phase phospholipid (DSPC). The objective of this work was to c... | ['Administration, Inhalation', 'Calorimetry, Differential Scanning', 'Drug Compounding', 'Drug Delivery Systems', 'Dry Powder Inhalers', 'Glass', 'Microscopy, Electron, Scanning', 'Technology, Pharmaceutical', 'Thermogravimetry', 'Tobramycin'] | 28,418,683 | [['E02.319.267.050'], ['E05.196.131.310', 'E05.196.370.310'], ['E05.916.270'], ['E02.319.300'], ['E07.605.500'], ['J01.637.437'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['E05.916', 'J01.897.836'], ['E05.196.904'], ['D09.408.051.476.600.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Management of upper gastrointestinal bleeding in cirrhotic patients with documented esophageal varices evaluated at the Puerto Rico Medical Center. | Esophageal variceal bleeding is a frequent complication in patients with chronic liver disease. There is no published study that evaluates the management of this complication in Puerto Rico. Our study describes the management of patients with esophageal varices admitted to the emergency room of the Puerto Rico Medical ... | ['Esophageal and Gastric Varices', 'Female', 'Gastrointestinal Hemorrhage', 'Health Facilities', 'Humans', 'Liver Cirrhosis', 'Male', 'Puerto Rico', 'Retrospective Studies'] | 21,696,096 | [['C06.405.117.240', 'C06.552.494.414'], ['C06.405.227', 'C23.550.414.788'], ['N02.278'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.630', 'C23.550.355.412'], ['Z01.107.084.900.750', 'Z01.639.880.750'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.33... | ['Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Rapid implementation and improvement of a virtual student placement model in response to the COVID-19 pandemic. | Practice-based learning via clinical placement is a core part of a physiotherapy degree with the Chartered Society of Physiotherapy requiring completion of 1000 placement hours over a preregistration degree programme. In April 2020, as a result of the COVID-19 pandemic and subsequent lockdown Connect Health had to canc... | ['Betacoronavirus', 'COVID-19', 'Coronavirus Infections', 'Humans', 'Internship, Nonmedical', 'Models, Educational', 'Pandemics', 'Physical Therapists', 'Pneumonia, Viral', 'SARS-CoV-2', 'Students, Health Occupations', 'Telemedicine'] | 33,148,602 | [['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['C01.925.782.600.550.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.750'], ['E05.599.545', 'I02.903.302'], ['N06.85... | ['Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Two-Colored Dental Surveying Tool as an Alternative for Carbon Marker. | Various tools are used with a dental surveyor, including analyzing rods, carbon markers, undercut gauges, and protective sheaths for a specific function. A carbon marker is a parallel-sided carbon rod used to mark the survey line on a cast or a crown on a cast. The carbon marker (with or without protective sheath) cann... | ['Carbon', 'Color', 'Dental Casting Technique', 'Dental Prosthesis Design', 'Humans'] | 26,683,255 | [['D01.268.150'], ['G01.590.540.199'], ['E06.780.250', 'E06.912.115'], ['E06.780.346.625', 'E06.912.145'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The study of early human embryos using interactive 3-dimensional computer reconstructions. | Tracings of serial histological sections from 4 human embryos at different Carnegie stages were used to create 3-dimensional (3D) computer models of the developing heart. The models were constructed using commercially available software developed for graphic design and the production of computer generated virtual reali... | ['Computer Communication Networks', 'Computer Simulation', 'Heart', 'Humans', 'Image Processing, Computer-Assisted'] | 9,279,665 | [['L01.224.230.110'], ['L01.224.160'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308']] | ['Information Science [L]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Abdominal apoplexy. | Two cases of the rare condition of abdominal apoplexy are described. The two main clincial presentations of this condition are discussed as is the aetiology. It is suggested that selective visceral angiography might prove helpful in preoperative diagnosis. | ['Abdomen', 'Adult', 'Hemorrhage', 'Humans', 'Male', 'Mesenteric Arteries', 'Middle Aged', 'Rupture, Spontaneous'] | 647,195 | [['A01.923.047'], ['M01.060.116'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.114.565'], ['M01.060.116.630'], ['C23.300.909']] | ['Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A distal enhancer region in the human beta-casein gene mediates the response to prolactin and glucocorticoid hormones. | The 5' flanking region of the human beta-casein gene was investigated for the presence of regulatory sequences mediating the action of the lactogenic hormones prolactin and dexamethasone. DNA encompassing 9389 base pairs of the flanking region was isolated and a sequence comparison performed with regulatory regions pre... | ['Animals', 'Base Sequence', 'Binding Sites', 'COS Cells', 'Caseins', 'Cattle', 'Cloning, Molecular', 'Conserved Sequence', 'Dexamethasone', 'Enhancer Elements, Genetic', 'Gene Expression Regulation', 'Genes, Reporter', 'Genomic Library', 'Goats', 'Humans', 'Mice', 'Molecular Sequence Data', 'Prolactin', 'Rabbits', 'Ra... | 9,795,185 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['A11.251.210.172.500', 'A11.329.228.220'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['B01.050.150.900.649.313.500.380.271'], ['E05.393.220'], ['G02.111.570.580'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Comparison of sensory perception and verbal expression of Korean Kimchi stews between Chinese consumers and Korean trained panelists. | BACKGROUND: Sensory drivers of liking in foreign food markets are difficult to identify because the expression of perceived characteristics varies depending on cultural differences. We aimed to identify differences in the perception and expression of a Korean home meal replacement product (Kimchi stew) between 10 Korea... | ['Adult', 'Brassica', 'China', 'Consumer Behavior', 'Cooking', 'Female', 'Fermented Foods and Beverages', 'Humans', 'Male', 'Republic of Korea', 'Taste', 'Taste Perception', 'Vegetables', 'Young Adult'] | 29,797,725 | [['M01.060.116'], ['B01.650.940.800.575.912.250.157.200'], ['Z01.252.474.164'], ['F01.145.236'], ['J01.576.423.200.200'], ['G07.203.200', 'J02.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.557.750'], ['F02.830.816.724', 'G11.561.790.724'], ['F02.463.593.817'], ['B01.650.160.956', 'B01.650.510.95... | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 |
Insulin binding to liver nuclei from lean and obese mice is altered by dietary fat. | Insulin binding to the plasma membrane is known to be altered by modifying the membrane composition through dietary treatment. As insulin binding receptors are also present on nuclear membrane, this study was undertaken to investigate if specific binding of insulin to the liver nuclei is altered by diet. 8-wk-old femal... | ['Animals', 'Body Weight', 'Dietary Fats', 'Fatty Acids', 'Female', 'Insulin', 'Liver', 'Mice', 'Mice, Obese', 'Nuclear Envelope', 'Organ Size', 'Phospholipids', 'Receptor, Insulin'] | 1,627,590 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['D10.251'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['B... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Effects of Gardenia-aweto compound by different extraction method on antagonizing acute respiratory distress syndrome]. | OBJECTIVE: To study the effect of Gardenia-Aweto compound (GAC) and two component on preventing acute respiratory distress syndrome (ARDS) by the rabbit model of ARDS induced by intravenous injection of oleic acid. To detect the efficiency component of GAC in preventing ARDS.METHOD: GAC was divided into two compounts, ... | ['Animals', 'Cordyceps', 'Drug Combinations', 'Drugs, Chinese Herbal', 'Female', 'Gardenia', 'Lepidoptera', 'Male', 'Materia Medica', 'Oleic Acid', 'Phytotherapy', 'Pulmonary Gas Exchange', 'Rabbits', 'Random Allocation', 'Respiratory Distress Syndrome'] | 16,075,739 | [['B01.050'], ['B01.300.107.501.220'], ['D26.310'], ['D20.215.784.500.350', 'D26.335'], ['B01.650.940.800.575.912.250.456.937.388'], ['B01.050.500.131.617.720.500.500.937'], ['D26.526'], ['D10.251.355.325.600.525'], ['E02.190.755'], ['E01.370.386.700.650', 'G03.143.775.602', 'G09.772.705.760.602'], ['B01.050.150.900.64... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[The syndrome of inappropriate secretion of antidiuretic hormone and the urinary excretion of aldosterone (author's transl)]. | The syndrome of inappropriate ADH secretion was diagnosed on the basis of the cardinal features described by Bartter and Schwartz in 3 patients: one neonate with bacterial meningitis and two children respectively under Vincristin and Cyclophosphamide treatment. Treatment with fluid restriction and infusions of hyperton... | ['Aldosterone', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Meningitis', 'Metabolic Diseases', 'Syndrome', 'Vasopressins'] | 1,189,523 | [['D04.210.500.745.745.654.062', 'D06.472.040.585.353.118'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C10.228.614'], ['C18.452'], ['C23.550.288.500'], ['D06.472.699.631.692.781', 'D12.644.400.900', 'D12.644.456.925', 'D12.644.548.691.692.781', 'D12.77... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. | Inactivation of beta-catenin in mesenchymal progenitors prevents osteoblast differentiation; inactivation of Lrp5, a gene encoding a likely Wnt coreceptor, results in low bone mass (osteopenia) by decreasing bone formation. These observations indicate that Wnt signaling controls osteoblast differentiation and suggest t... | ['Animals', 'Bone Development', 'Cell Differentiation', 'Cytoskeletal Proteins', 'Gene Expression Regulation, Developmental', 'Glycoproteins', 'In Situ Hybridization', 'Intercellular Signaling Peptides and Proteins', 'LDL-Receptor Related Proteins', 'Lac Operon', 'Low Density Lipoprotein Receptor-Related Protein-5', 'M... | 15,866,165 | [['B01.050'], ['G07.345.500.325.377.625.050.500', 'G11.427.578.050.500'], ['G04.152'], ['D12.776.220'], ['G05.308.310'], ['D09.400.430', 'D12.776.395'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['D12.644.276', 'D12.776.467',... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An unusual cause of multiple organ dysfunction syndrome in the pediatric intensive care unit: hemophagocytic lymphohistiocytosis. | OBJECTIVE: To report our experience in children with primary or secondary hemophagocytic lymphohistiocytosis (HLH) presented with multiple organ dysfunction syndrome (MODS) in pediatric intensive care unit (PICU).DESIGN: The records of patients with a diagnosis of HLH and MODS between January 2005 and January 2008 were... | ['Adolescent', 'Child', 'Child, Preschool', 'Diagnosis, Differential', 'Female', 'Humans', 'Infant', 'Intensive Care Units, Pediatric', 'Length of Stay', 'Lymphohistiocytosis, Hemophagocytic', 'Male', 'Multiple Organ Failure', 'Retrospective Studies', 'Severity of Illness Index', 'Treatment Outcome'] | 19,433,941 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['N02.278.388.493.390'], ['E02.760.400.480', 'N02.421.585.400.480'], ['C15.604.250.410.575'], ['C23.550.835.525'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.33... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transformation of follicular lymphoma to diffuse large B-cell lymphoma proceeds by distinct oncogenic mechanisms. | This study was undertaken to further elucidate the biological mechanisms underlying the frequent event of transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (t-FL). The gene expression profiles of 20 paired lymph node biopsies, derived from the same patient pre- and post-transformation, were an... | ['Cell Proliferation', 'Cell Transformation, Neoplastic', 'Disease Progression', 'Gene Expression Profiling', 'Genes, myc', 'Humans', 'Lymphoma, Follicular', 'Lymphoma, Large B-Cell, Diffuse', 'Oligonucleotide Array Sequence Analysis', 'Tumor Suppressor Protein p53'] | 17,278,262 | [['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C23.550.291.656'], ['E05.393.332'], ['G05.360.340.024.340.375.500.791.420'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386.480.350', 'C15.604.515.569.480.350', 'C20.683.515.761.480.350'], ['C04.557.386.480.150.585', ... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytogenetic analysis of diploidy in cloned bovine embryos using an improved air-dry karyotyping method. | Of the few published studies on the cytogenetic analyses of bovine nuclear transferred (NT) embryos, results differ between air-dry and fluorescent in situ hybridization (FISH) procedures. A modified air-dry procedure is reported in this study that provides more metaphase plates for analysis. Day 5 and Day 7 bovine NT ... | ['Animals', 'Cattle', 'Cloning, Organism', 'Cytogenetic Analysis', 'Diploidy', 'In Situ Hybridization, Fluorescence', 'Karyotyping', 'Mitosis', 'Nuclear Transfer Techniques'] | 15,910,924 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.393.240', 'E05.820.180'], ['E01.370.225.500.385', 'E05.200.500.385', 'E05.242.385', 'E05.393.285'], ['G05.700.264'], ['E01.370.225.500.620.670.325.350', 'E01.370.225.750.600.670.325.350', 'E05.200.500.620.670.325.350', 'E05.200.750.600.670.325.350', 'E05.393.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part III: Effects on complex carbohydrates of lung connective tissue. | Glycosaminoglycans are constituents of proteoglycans, which are integral components of lung connective tissue. Glycosaminoglycans not only provide structural support to organs, but also influence extracellular matrix assembly, cell adhesion, and cell proliferation. Changes in the metabolism of glycosaminoglycans have b... | ['Animals', 'Antithrombin III', 'Carbohydrates', 'Chromatography, Affinity', 'Chromatography, High Pressure Liquid', 'Connective Tissue', 'Environmental Exposure', 'Glycosaminoglycans', 'Heparitin Sulfate', 'Lung', 'Male', 'Ozone', 'Proteoglycans', 'Rats', 'Rats, Inbred F344'] | 7,811,421 | [['B01.050'], ['D12.644.861.060.500', 'D12.776.124.790.106.125', 'D12.776.377.715.085.125', 'D12.776.872.060.500', 'D23.113.025'], ['D09'], ['E05.196.181.400.170'], ['E05.196.181.400.300'], ['A10.165'], ['N06.850.460.350'], ['D09.698.373'], ['D09.698.373.425'], ['A04.411'], ['D01.362.670.600'], ['D09.698.735', 'D12.776... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
On the efficiency and reversibility of active ligand transport induced by alternating rectangular electric pulses. | The stationary-state kinetic properties of a simplified two-state electro-conformational coupling model (ECC) in the presence of alternating rectangular electric potential pulses are derived analytically. Analytic expressions for the transport flux, the rate of electric energy dissipation, and the efficiency of the tra... | ['Carrier Proteins', 'Cell Membrane', 'Electrophysiology', 'Kinetics', 'Ligands', 'Mathematics', 'Membrane Potentials', 'Models, Biological'] | 8,075,348 | [['D12.776.157'], ['A11.284.149'], ['H01.158.344.528', 'H01.158.782.236'], ['G01.374.661', 'G02.111.490'], ['D27.720.470.480'], ['H01.548'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E05.599.395']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Histological and immunocytochemical characterization of neurons located in the white matter of the spinal cord of the pigeon. | In the spinal cord of birds a considerable number of neuronal somata is located outside the gray matter. Some of these neurons form segmental marginal nuclei, which lie at the border of the spinal cord near the dentate ligament. In lumbosacral segments these marginal nuclei form accessory lobes which bulge into the ver... | ['Animals', 'Astrocytes', 'Columbidae', 'Glial Fibrillary Acidic Protein', 'Glutamate Decarboxylase', 'Immunohistochemistry', 'Lumbosacral Region', 'Neurofilament Proteins', 'Neurons', 'Receptors, AMPA', 'Spinal Cord'] | 15,121,215 | [['B01.050'], ['A08.637.200', 'A11.650.200'], ['B01.050.150.900.248.165.150'], ['D05.750.078.593.400', 'D12.776.220.475.400'], ['D08.811.520.224.125.250'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512'... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Hardness, softness, and the fukui function in the electronic theory of metals and catalysis. | The concepts of hardness eta = (2E/N2)nu and fukui function f(r) = [rho (r)/N]nu, which have recently been associated with the theory of chemical reactivity in molecules, are extended to the theory of metals. It is shown that at T = 0, 1/eta = g(epsilon F) and f(r) = g(epsilon F, r)/g(epsilon F), where g(epsilon F), an... | ['Chemical Phenomena', 'Chemistry', 'Mathematics', 'Metals'] | 3,863,123 | [['G02'], ['H01.181'], ['H01.548'], ['D01.552']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Affection of exogenous gibberellic acid (GA3) on endogenus hormones of Panax quinquefolium seed during its morphological after ripening period]. | According to the determination of endogenus hormones variation of Panax quinquefolium seed during its morphological afterripenging period, and the affection of exo-GA3 on the endogenus hormones dynamics, it suggested that exo-GA3 couldn't be used for accelerate the growth of Panax quinquefolium embryo, but was helpful ... | ['Abscisic Acid', 'Germination', 'Gibberellins', 'Panax', 'Plant Growth Regulators', 'Plants, Medicinal', 'Quality Control', 'Seeds'] | 12,575,034 | [['D02.241.223.268.034', 'D02.455.326.271.665.202.061', 'D02.455.426.392.368.367.379.249.024', 'D02.455.849.131.061', 'D02.455.849.765.521.500'], ['G07.345.625.249', 'G15.357'], ['D02.455.849.291.239.500'], ['B01.650.940.800.575.912.250.087.500'], ['D27.505.696.377.760'], ['B01.650.560'], ['J01.897.608'], ['A18.024.500... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The role of chloride on deoxycorticosterone acetate-salt hypertension. | Selective sodium loading attenuated the development of hypertension in the deoxycorticosterone acetate (DOCA) treated rat. The DOCA treated rat fed a diet equimolar in sodium to a 7% sodium chloride diet and in chloride to a standard diet, differed in various parameters from the DOCA treated rat fed a 7% sodium chlorid... | ['Animals', 'Blood Pressure', 'Chlorides', 'Desoxycorticosterone', 'Electrolytes', 'Erythrocytes', 'Heart Rate', 'Humans', 'Hypertension', 'Male', 'Rats', 'Rats, Inbred Strains', 'Sodium', 'Sodium Chloride', 'Sodium, Dietary'] | 3,430,690 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D04.210.500.745.745.654.339', 'D06.472.040.585.611'], ['D01.248'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Late ischemia and carpal tunnel syndrome secondary to catheterization of the radial artery]. | Invasive measurement of blood pressure has many advantages. Although arterial canalization is a low-risk technique of great benefit to the patient, complications must be looked for. We report the case of a man who underwent triple coronary bypass with arterial canalization requiring several punctures to achieve. Two we... | ['Aged', 'Carpal Tunnel Syndrome', 'Catheterization, Peripheral', 'Hand', 'Humans', 'Ischemia', 'Male', 'Monitoring, Intraoperative', 'Postoperative Complications', 'Radial Artery', 'Regional Blood Flow'] | 9,280,998 | [['M01.060.116.100'], ['C10.668.829.500.500.200', 'C10.668.829.550.200', 'C26.844.150.206'], ['E02.148.224', 'E04.100.814.529.937', 'E04.502.382.937', 'E05.157.375'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.513'], ['E01.370.520.510', 'E04.510'], ['C23.550.767'], ['A07.015.114.740... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex. | The Drosophila Glued gene product shares sequence homology with the p150 component of vertebrate dynactin. Dynactin is a multiprotein complex that stimulates cytoplasmic dynein-mediated vesicle motility in vitro. In this report, we present biochemical, cytological, and genetic evidence that demonstrates a functional si... | ['Animals', 'Drosophila', 'Dynactin Complex', 'Dyneins', 'Female', 'Gene Expression', 'Microtubule Proteins', 'Microtubule-Associated Proteins', 'Microtubules', 'Mutation', 'Oogenesis'] | 7,593,168 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D05.500.142', 'D12.776.220.600.450.150', 'D12.776.631.560.225'], ['D08.811.277.040.013.500.063', 'D08.811.277.040.025.024.063', 'D08.811.277.040.025.193.249', 'D12.776.157.025.750.063', 'D12.776.220.600.200'], ['G05.297'], ['D05.750.078.734', 'D12.776.220... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Kinetics of cell populations at various stages of the histogenesis of tissues of the chorioallantois of the chick embryo. Parameters of cell cycles]. | By means of thymidine autoradiography, changes of the proliferative pool and those of the cellular cycle parameters have been studied in tissues of the chorioallantois and in the duodenal epithelium of the chick embryo at various stages of development. The decisive role in regulation of proliferation in the cell popula... | ['Allantois', 'Animals', 'Cell Cycle', 'Chick Embryo', 'Chorion', 'DNA', 'Duodenum', 'Epithelial Cells', 'Extraembryonic Membranes', 'Kinetics', 'Morphogenesis'] | 3,718,254 | [['A10.615.284.147', 'A16.254.750.147'], ['B01.050'], ['G04.144'], ['A13.350.150', 'A16.331.200'], ['A10.615.284.473', 'A16.254.750.473'], ['D13.444.308'], ['A03.556.124.684.124', 'A03.556.875.249'], ['A11.436'], ['A10.615.284', 'A16.254.750'], ['G01.374.661', 'G02.111.490'], ['G07.345.500']] | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Epidemiology of enteroaggregative Escherichia coli infections and associated outcomes in the MAL-ED birth cohort. | BACKGROUND: Enteroaggregative E. coli (EAEC) have been associated with mildly inflammatory diarrhea in outbreaks and in travelers and have been increasingly recognized as enteric pathogens in young children with and without overt diarrhea. We examined the risk factors for EAEC infections and their associations with env... | ['Age Distribution', 'Biomarkers', 'Child Health', 'Cohort Studies', 'Diarrhea', 'Disease Outbreaks', 'Escherichia coli', 'Escherichia coli Infections', 'Feces', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'International Cooperation', 'Linear Models', 'Male', 'Multivariate Analysis', 'Risk Factors', 'Virulence'] | 28,742,106 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['D23.101'], ['N01.400.225'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C23.888.821.214'], ['N06.850.290'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['A12.459'], ['B01.050.150.900.6... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Purification, biochemical characterization and structural modelling of alkali-stable â-1,4-xylan xylanohydrolase from Aspergillus fumigatus R1 isolated from soil. | BACKGROUND: Aspergillus fumigatus R1 produced xylanase under submerged fermentation which degrades the complex hemicelluloses contained in agricultural substrates. Xylanases have gained considerable attention because of their tremendous applications in industries. The purpose of our study was to purify xylanase and stu... | ['Amino Acid Sequence', 'Aspergillus fumigatus', 'Endo-1,4-beta Xylanases', 'Enzyme Stability', 'Hydrogen-Ion Concentration', 'Kinetics', 'Models, Molecular', 'Molecular Sequence Data', 'Soil Microbiology', 'Temperature'] | 26,847,222 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.300.381.081.295'], ['D08.811.277.450.950.249'], ['E05.916.360', 'G02.111.700.500'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['E05.599.595'], ['L01.453.245.667'], ['H01.158.273.540.274.555', 'N06.850.425.300'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.75... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system. | BACKGROUND AND PURPOSE: Topiramate improves insulin sensitivity, in addition to its antiepileptic action. However, the underlying mechanism is unknown. Therefore, the present study was aimed at investigating the mechanism of the insulin-sensitizing effect of topiramate both in vivo and in vitro.EXPERIMENTAL APPROACH: M... | ['Animals', 'Anticonvulsants', 'Blood Glucose', 'Cell Line', 'Central Nervous System', 'Diet, High-Fat', 'Disease Models, Animal', 'Fructose', 'Infusions, Intraventricular', 'Insulin', 'Insulin Resistance', 'KATP Channels', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Muscle Fibers, Skeletal', 'Potassium Channel Blockers', '... | 23,957,854 | [['B01.050'], ['D27.505.954.427.080'], ['D09.947.875.359.448.500'], ['A11.251.210'], ['A08.186'], ['G07.203.650.240.267'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D09.947.875.359.250', 'D09.947.875.465.354'], ['E02.319.267.510.692'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['C18.452.394... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[W?nderlich syndrome due to a ruptured iliac vein secondary to deep venous thrombosis]. | W?nderlich syndrome, or spontaneous retroperitoneal hematoma, secondary to spontaneous rupture of the iliac vein is a rare clinical entity and a medical emergency. Often the aetiology is difficult to identify and different hypotheses have been proposed, such as the presence of hormonal, inflammatory and/or mechanical f... | ['Female', 'Hematoma', 'Humans', 'Iliac Vein', 'Middle Aged', 'Retroperitoneal Space', 'Rupture, Spontaneous', 'Syndrome', 'Venous Thrombosis'] | 30,012,315 | [['C23.550.414.838'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.908.427'], ['M01.060.116.630'], ['A01.923.047.025.750'], ['C23.300.909'], ['C23.550.288.500'], ['C14.907.355.830.925']] | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A Combined Nomogram Model to Preoperatively Predict Histologic Grade in Pancreatic Neuroendocrine Tumors. | PURPOSE: The purpose of this study is to develop and validate a nomogram model combing radiomics features and clinical characteristics to preoperatively differentiate grade 1 and grade 2/3 tumors in patients with pancreatic neuroendocrine tumors (pNET).Experimental Design: A total of 137 patients who underwent contrast... | ['Adult', 'Aged', 'Aged, 80 and over', 'Algorithms', 'Carcinoma, Neuroendocrine', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Middle Aged', 'Neoplasm Grading', 'Nomograms', 'Pancreatic Neoplasms', 'Preoperative Period', 'Prognosis', 'ROC Curve', 'Tomography, X-Ray Computed', 'Tumor Burden', 'Wor... | 30,397,175 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G17.035', 'L01.224.050'], ['C04.557.465.625.650.240', 'C04.557.470.200.025.370', 'C04.557.580.625.650.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['M01.060.116.630'], ['E01.789.612'], ['E01.789.650', 'E05.318.740.500.625', 'E... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Hypertension-related mortality in California. | Death rates in California for hypertension-related diseases during 1969-71 and 1979-81 are compared. During both periods, age-standardized rates for a composite hypertension-related mortality category are highest for blacks, followed by whites, and lowest for Asians and Pacific Islanders. Filipinos who have high preval... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'California', 'Child', 'Child, Preschool', 'Continental Population Groups', 'Epidemiologic Methods', 'Female', 'Health Status', 'Heart Diseases', 'Humans', 'Hypertension', 'Infant', 'Infant, Newborn', 'Male', 'Middle Aged', 'Sex Factors', 'Time Factors'] | 3,080,788 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['M01.060.406'], ['M01.060.406.448'], ['M01.686.508'], ['E05.318', 'N06.850.520'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['C14.280'], ['B01.050.150.900... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours. | Germline mutations in the tumour suppressor BRCA2 predispose to breast, ovarian and a number of other human cancers. Brca2-deficient mouse models are used for preclinical studies but the pattern of genomic alterations in these tumours has not yet been described in detail. We have performed whole-exome DNA sequencing an... | ['Animals', 'Antigens, CD', 'Breast Neoplasms', 'Chromosomal Proteins, Non-Histone', 'DNA Copy Number Variations', 'DNA, Neoplasm', 'Disease Models, Animal', 'Female', 'Gene Knockout Techniques', 'Genes, BRCA2', 'Germ-Line Mutation', 'Humans', 'Mammary Neoplasms, Experimental', 'Mice, Transgenic', 'Mutation, Missense',... | 25,692,405 | [['B01.050'], ['D23.050.301.264.035', 'D23.101.100.110'], ['C04.588.180', 'C17.800.090.500'], ['D12.776.660.235', 'D12.776.664.235'], ['G05.365.795.297.500'], ['D13.444.308.425'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.393.335.750'], ['G05.360.340.024.340.375.249.105', 'G05.360.340.024.340.415.400.105'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Geographic variation in the prevalence of stimulant medication use among children 5 to 14 years old: results from a commercially insured US sample. | OBJECTIVE: The purpose of this study was to evaluate geographic variation in the prevalence of prescription stimulant use and predictors of use among a nationally representative, commercially insured population 5 to 14 years old.METHODS: Prescription claims activity from January 1, 1999 through December 31, 1999 for a ... | ['Adolescent', 'Age Factors', 'Central Nervous System Stimulants', 'Child', 'Child, Preschool', 'Drug Prescriptions', 'Humans', 'Insurance, Pharmaceutical Services', 'Linear Models', 'Logistic Models', 'Multivariate Analysis', 'Predictive Value of Tests', 'Rural Health Services', 'Sex Factors', 'Socioeconomic Factors',... | 12,563,045 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['D27.505.696.282', 'D27.505.954.427.220'], ['M01.060.406'], ['M01.060.406.448'], ['E02.319.307', 'N02.421.668.778.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.343.575'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.75... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Muscle activation during maximum voluntary contraction and m-wave related in healthy but not in injured conditions: Implications when normalizing electromyography. | BACKGROUND: Electromyography signal amplitude is influenced by a variety of factors. Normalization strategies aimed at decreasing signal variability include using peak electromyography signal during a maximum voluntary contraction and peak-to-peak M-wave amplitude. However, whether these normalization methods are compa... | ['Achilles Tendon', 'Adult', 'Electromyography', 'Female', 'Healthy Volunteers', 'Humans', 'Male', 'Middle Aged', 'Muscle Contraction', 'Muscle, Skeletal', 'Rupture', 'Tendon Injuries'] | 31,326,725 | [['A02.880.176'], ['M01.060.116'], ['E01.370.405.255', 'E01.370.530.255'], ['M01.774.500', 'M01.955.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G11.427.494'], ['A02.633.567', 'A10.690.552.500'], ['C26.761'], ['C26.874']] | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Visual processing speed. | Older adults commonly report difficulties in visual tasks of everyday living that involve visual clutter, secondary task demands, and time sensitive responses. These difficulties often cannot be attributed to visual sensory impairment. Techniques for measuring visual processing speed under divided attention conditions ... | ['Activities of Daily Living', 'Aging', 'Attention', 'Humans', 'Reaction Time', 'Vision Disorders', 'Visual Perception'] | 23,231,958 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['G07.345.124'], ['F02.830.104.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['C10.597.751.941', 'C11.966', 'C23.888.592.763.941'], ['F02.463.593.932']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human. | A general toxicity of basic drugs is related to phospholipidosis in tissues. Therefore, it is essential to predict the tissue distribution of basic drugs to facilitate an initial estimate of that toxicity. The objective of the present study was to further assess the original prediction method that consisted of using th... | ['Animals', 'Drug-Related Side Effects and Adverse Reactions', 'Humans', 'Lipidoses', 'Models, Biological', 'Pharmaceutical Preparations', 'Phospholipids', 'Rats', 'Tissue Distribution'] | 21,034,759 | [['B01.050'], ['C25.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C16.320.565.398.641', 'C18.452.584.687', 'C18.452.648.398.641'], ['E05.599.395'], ['D26'], ['D10.570.755'], ['B01.050.150.900.649.313.992.635.505.700'], ['G03.787.917', 'G07.690.725.949']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chemotherapeutics: a questionable or a promising project. | While repository adjuvants are already established drugs for antigen specific immunomodulation, no unspecific active immunomodulator has successfully passed clinical trials in tumor patients in Western countries yet. As this is in striking contrast to the effects seen with unspecific immunomodulators in experimental im... | ['Adjuvants, Immunologic', 'Animals', 'Chronic Disease', 'Disease Models, Animal', 'Drug Evaluation, Preclinical', 'Humans', 'Immunotherapy', 'Infections', 'Leucine', 'Lymphocytes', 'Macrophage Activation', 'Neoplasms, Experimental'] | 3,791,955 | [['D27.505.696.477.067'], ['B01.050'], ['C23.550.291.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.290.750', 'E05.337.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425'], ['C01'], ['D12.125.070.637', 'D12.125.142.441'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.49... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis. | We have identified a Dictyostelium discoideum gene encoding a serine/threonine kinase, PAKa, a putative member of the Ste20/PAK family of p21-activated kinases, with a kinase domain and a long NH(2)-terminal regulatory domain containing an acidic segment, a polyproline domain, and a CRIB domain. PAKa colocalizes with m... | ['Actins', 'Amino Acid Sequence', 'Animals', 'Cell Division', 'Cell Polarity', 'Chemotaxis', 'Cloning, Molecular', 'Cyclic AMP', 'Cytoskeleton', 'Dictyostelium', 'Enzyme Activation', 'Gene Deletion', 'Giant Cells', 'Intracellular Signaling Peptides and Proteins', 'MAP Kinase Kinase Kinases', 'Molecular Sequence Data', ... | 10,545,500 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.250'], ['F01.145.113.780.500', 'F01.145.875.439.500.500', 'G04.198.424', 'G07.568.500.590.500', 'G11.427.410.56... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of LH-RH and hypothalamic extracts on 3'-5'-cyclic-AMP pituitary levels of immature and adult female rats in vivo. | Adult female rat hypothalamic extract and LH-RH increased the 3'-5'-cyclic-AMP (cAMP) level of immature pituitary in vivo, while immature female rat hypothalamic extract had the opposite effect. LH-RH and immature female rat hypothalamic extract did not change the cAMP pituitary levels 60 min after injection to adult f... | ['Animals', 'Cyclic AMP', 'Female', 'Gonadotropin-Releasing Hormone', 'Pituitary Gland', 'Rats', 'Stimulation, Chemical'] | 6,248,929 | [['B01.050'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405.740.320'], ['A06.300.747', 'A06.688.357.750', 'A08.186.211.180.497.352.435.500', 'A08.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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