Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues. | The selective entry of nanoparticles into target tissues is the key factor which determines their tissue distribution. Entry is primarily controlled by microvascular endothelial cells, which have tissue-specific properties. This study investigated the cellular properties involved in selective transport of gold nanopart... | ['Animals', 'Biological Transport', 'Brain', 'Cytosol', 'Endocytosis', 'Endothelial Cells', 'Endothelium, Vascular', 'Gold', 'Humans', 'Kidney', 'Male', 'Metal Nanoparticles', 'Microscopy, Electron, Transmission', 'Polyethylene Glycols', 'Polysaccharides', 'Rats', 'Rats, Wistar', 'Tissue Distribution'] | 27,560,685 | [['B01.050'], ['G03.143'], ['A08.186.211'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['G04.417'], ['A11.436.275'], ['A07.015.700.500', 'A10.272.491.355'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['J01.637.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Multiscale noise suppression and feature frequency extraction in SSVEP based on underdamped second-order stochastic resonance. | OBJECTIVE: As one of the commonly used control signals of brain-computer interface (BCI), steady-state visual evoked potential (SSVEP) exhibits advantages of stability, periodicity and minimal training requirements. However, SSVEP retains the non-linear, non-stationary and low signal-to-noise ratio (SNR) characteristic... | ['Adult', 'Electroencephalography', 'Evoked Potentials, Visual', 'Female', 'Humans', 'Male', 'Photic Stimulation', 'Signal-To-Noise Ratio', 'Stochastic Processes', 'Young Adult'] | 30,959,496 | [['M01.060.116'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500.425', 'G11.561.200.500.425', 'G14.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.723.729'], ['E05.318.370.800.875', 'E05.318.740.872.875', 'G17.800.500', 'N05.715.360.325.700.840', 'N05.715.360.750.725.750', 'N06.850.520.445.800.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Accountability for quality of care: Monitoring all aspects of quality across a framework adapted for action. | Quality of care is essential to maternal and newborn survival. The multidimensional nature of quality of care means that frameworks are useful for capturing it. The present paper proposes an adaptation to a widely used quality of care framework for maternity services. The framework subdivides quality into two inter-rel... | ['Continuity of Patient Care', 'Female', 'Humans', 'Infant, Newborn', 'Maternal-Child Health Services', 'Nigeria', 'Pregnancy', 'Quality of Health Care', 'Social Responsibility'] | 26,723,043 | [['E02.760.169', 'N02.421.585.169', 'N04.590.233.727.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N02.421.143.130.660', 'N02.421.143.620.275'], ['Z01.058.290.190.565'], ['G08.686.784.769'], ['N04.761', 'N05.715'], ['F01.829.500.760', 'K01.752.566.869']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
National practice patterns and time trends in androgen ablation for localized prostate cancer. | BACKGROUND: Recent reports have suggested that growing numbers of patients with localized prostate cancer are receiving androgen deprivation therapy as primary or neoadjuvant treatment, yet sparse clinical evidence supports the use of such treatment except among patients with high-risk or locally advanced disease recei... | ['Aged', 'Androgen Antagonists', 'Antineoplastic Agents, Hormonal', 'Chemotherapy, Adjuvant', 'Drug Administration Schedule', 'Drug Utilization', 'Humans', 'Male', 'Middle Aged', 'Neoadjuvant Therapy', 'Neoplasm Staging', 'Practice Guidelines as Topic', "Practice Patterns, Physicians'", 'Prostate-Specific Antigen', 'Pr... | 12,837,834 | [['M01.060.116.100'], ['D06.347.065', 'D27.505.696.399.450.065'], ['D27.505.954.248.169'], ['E02.186.170', 'E02.319.170'], ['E02.319.283'], ['N04.452.706.477'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.186.450'], ['E01.789.625'], ['N04.761.700.350.650', 'N05.700.350.650'], ['N04.590.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A microcomputer program to analyze the CD spectrum of proteins and nucleic acids--use of LOTUS 1-2-3 spread sheet. | A user friendly interactive computer program, CIRDIC, is developed which calculates the molar ellipticity and molar circular dichroic absorption coefficients from the CD spectrum. This, in combination with LOTUS 1-2-3 spread sheet, will give the spectra of above parameters vs wavelength. The code is implemented in Micr... | ['Algorithms', 'Circular Dichroism', 'Humans', 'Microcomputers', 'Nucleic Acids', 'Proteins', 'Software'] | 1,790,689 | [['G17.035', 'L01.224.050'], ['E05.196.867.151'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.260.550'], ['D13.444'], ['D12.776'], ['L01.224.900']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The corticotropin-releasing factor receptor 1 antagonist CP-154,526 reverses stress-induced learning deficits in mice. | The neuropeptide corticotropin-releasing factor (CRF) coordinates the endocrine responses to stress as a major physiological regulator of the hypothalamic-pituitary-adrenal axis. We assessed the effect of the non-peptidergic CRF receptor 1 antagonist CP-154,526 on stress-induced changes in context-dependent fear condit... | ['Animals', 'Arousal', 'Calcium-Calmodulin-Dependent Protein Kinases', 'Conditioning, Classical', 'Culture Techniques', 'Fear', 'Hippocampus', 'Hypothalamo-Hypophyseal System', 'Injections, Intraperitoneal', 'Long-Term Potentiation', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Neuronal Plasticity', 'Pituitary-Adrenal Syste... | 12,527,451 | [['B01.050'], ['F02.830.104', 'G11.561.035'], ['D08.811.913.696.620.682.700.125', 'D12.644.360.100', 'D12.776.476.100'], ['F02.463.425.179.308'], ['E05.481.500'], ['F01.470.361'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['A06.688.357', 'A08.186.211.180.497.352.435', 'A08.186.211.200.317.357.352.435'... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Pneumothorax in neonates and infants]. | Pneumothorax in newborns and infants can have different etiologies: alveolar disruption following mechanic ventilation or reanimation, surgery for congenital diaphragmatic hernia or esophagus atresia, staphylococcal pneumonia, or thoracic traumas. We studied 105 cases of pneumothorax (96 newborns) treated in our hospit... | ['Diagnosis, Differential', 'Drainage', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Pneumothorax'] | 1,983,662 | [['E01.171'], ['E02.309', 'E04.237'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C08.528.778']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Multipoint linkage analysis. A cautionary note. | Multipoint linkage analysis is commonly used to evaluate linkage of a disease to multiple markers in a small region. Multipoint analysis is particularly powerful when the IBD relations of family members at the trait locus are ambiguous. The increased power arises because, unlike single-marker analyses, multipoint analy... | ['Computer Simulation', 'Genetic Linkage', 'Genetic Markers', 'Humans', 'Male', 'Models, Genetic', 'Models, Statistical', 'Polymorphism, Genetic', 'Prostatic Neoplasms'] | 10,436,380 | [['L01.224.160'], ['G05.348'], ['D23.101.387', 'G05.695.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.397'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['G05.365.795'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750']] | ['Information Science [L]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Approach, Technical Success, Complications, and Stent Patency of Sharp Recanalization for the Treatment of Chronic Venous Occlusive Disease: Experience in 123 Patients. | PURPOSE: To report the technical success and complications following sharp recanalization of chronic venous occlusions.MATERIALS AND METHODS: A total of 123 patients, including 75 (61.0%) men and 48 (39.0%) women, with mean age of 50.5 ± 17.5 years (range 19-90 years), underwent sharp recanalization of chronic venous o... | ['Adult', 'Aged', 'Aged, 80 and over', 'Arterial Occlusive Diseases', 'Chronic Disease', 'Endovascular Procedures', 'Female', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Stents', 'Treatment Outcome', 'Vascular Patency', 'Young Adult'] | 30,460,385 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.907.137'], ['C23.550.291.500'], ['E04.100.814.529', 'E04.502.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.8... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Current status of procedural skills training in physician assistant programs in the United States. | PURPOSE: To describe procedural skills training in physician assistant (PA) programs in the United States.METHODS: An online cross-sectional seven-item survey was administered to program directors of the then 154 accredited PA programs in the US in 2012. Outcome measures were: number of programs having formal skills li... | ['Clinical Competence', 'Cross-Sectional Studies', 'Curriculum', 'Educational Measurement', 'Humans', 'Learning', 'Physician Assistants', 'United States'] | 25,622,368 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I02.158'], ['I02.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['M01.526.485.067.740', 'N02.360.067.740'], ['Z01.107.567.875']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes. | RATIONALE: Cardiomyocytes generated from human induced pluripotent stem cells (hiPSCs) are suggested as the most promising candidate to replenish cardiomyocyte loss in regenerative medicine. Little is known about their calcium homeostasis, the key process underlying excitation-contraction coupling.OBJECTIVE: We investi... | ['Caffeine', 'Calcium', 'Carrier Proteins', 'Cell Culture Techniques', 'Cell Differentiation', 'Cell Line', 'Embryonic Stem Cells', 'Homeostasis', 'Humans', 'Induced Pluripotent Stem Cells', 'Muscle Proteins', 'Myocytes, Cardiac', 'Reverse Transcriptase Polymerase Chain Reaction', 'Ryanodine', 'Ryanodine Receptor Calci... | 21,614,516 | [['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.157'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.152'], ['A11.251.210'], ['A11.872.700.250'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A1... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subcellular localization of aldosterone-induced proteins in toad urinary bladders. | Paired toad urinary hemibladders were incubated with [35S]methionine in the presence (experimental) or absence (control) of aldosterone. Short-circuit current was used to monitor aldosterone-induced Na+ transport. Protein synthesis in epithelial cell subcellular fractions (cytosolic, microsomal, mitochondrial) was eval... | ['Aldosterone', 'Animals', 'Bufo marinus', 'Cytosol', 'Electrophoresis, Polyacrylamide Gel', 'In Vitro Techniques', 'Methionine', 'Microsomes', 'Molecular Weight', 'Protein Biosynthesis', 'Proteins', 'Sodium', 'Urinary Bladder'] | 6,783,090 | [['D04.210.500.745.745.654.062', 'D06.472.040.585.353.118'], ['B01.050'], ['B01.050.150.900.090.180.210.580'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['E05.196.401.402', 'E05.301.300.319'], ['E05.481'], ['D02.886.030.676', 'D12.125.142.557', 'D12.125.154.549', 'D12.125.166.676'], ['A11.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of addition of Tween 80 and potassium dihydrogenphosphate to basal medium on the isolation of marine eukaryotes, thraustochytrids. | Tween 80, KH(2)PO(4) and tomato juice were added to basal medium for the isolation of thraustochytrids. By the addition of Tween 80 and KH(2)PO(4), the number of thraustochytrids isolated from seawater increased. KH(2)PO(4) and Tween 80 were considered to be useful for isolating thraustochytrids. | ['Cell Separation', 'Culture Media', 'Eukaryotic Cells', 'Phosphates', 'Polysorbates', 'Potassium Compounds'] | 18,558,350 | [['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['D27.720.470.305', 'E07.206'], ['A11.450'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650'], ['D02.033.455.250.700.690', 'D05.750.741.700', 'D25.720.741.700', 'J01.637.051.720.741.700'], ['D01.745']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Encephalitis. | The CPD article provided information on encephalitis and focused on prioritising people and addressing the needs of the patient, their family and carers. The article encourages nurses to ensure that the fundamentals of care are delivered effectively and that physical, psychological and social needs are addressed. | ['Education, Nursing, Continuing', 'Encephalitis', 'Humans', 'United Kingdom'] | 26,838,658 | [['I02.358.212.450', 'I02.358.462.399'], ['C10.228.140.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.363']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Ultrasonography-accessed luteal size endpoint that most closely associates with circulating progesterone during the estrous cycle and early pregnancy in beef cows. | The aim was to evaluate the associations between circulating P4 concentrations, corpus luteum (CL) size (diameter, area or volume) and blood perfusion (BP) in cows. In Experiment 1, Pearson's correlations (P < 0.05) with P4 concentrations were observed during CL development (D8) for total area (TA; r = 0.76), luteal ar... | ['Animals', 'Cattle', 'Corpus Luteum', 'Estrous Cycle', 'Female', 'Ovulation', 'Pregnancy', 'Pregnancy, Animal', 'Progesterone', 'Ultrasonography'] | 30,583,812 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A05.360.319.114.630.278', 'A06.300.312.497.278'], ['G08.686.195'], ['G08.686.784.690'], ['G08.686.784.769'], ['G08.686.784.769.498'], ['D04.210.500.745.745.654.829', 'D06.472.334.734.623', 'D06.472.334.851.687.750'], ['E01.370.350.850']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical aspects of sleep disturbances and sleeping drugs. | Complaints about sleep disturbances are a common every-day problem in the general practitioner's surgery. Only a few patients need a thorough expert examination in a special sleep laboratory. Thanks to EEG, which makes available a continuous record of uninterrupted sleep cycles, knowledge of the physiology of sleep now... | ['Circadian Rhythm', 'Dreams', 'Electroencephalography', 'Humans', 'Sleep', 'Sleep Deprivation', 'Sleep Stages', 'Sleep Wake Disorders'] | 3,758,121 | [['G07.180.562.190'], ['F02.463.188.634.309', 'F02.830.855.268'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.830.855', 'G11.561.803'], ['C10.886.425.175', 'C23.888.592.796.772', 'F02.830.855.671', 'F03.870.400.099'], ['F02.830.855.796', 'G11.561.803.754'], ['C10.886',... | ['Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multilocus analyses of Renin-Angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioral stress in young normotensive subjects. | The renin-angiotensin-aldosterone system (RAAS) is a proteolytic cascade that regulates and maintains blood pressure (BP). This study aimed to explore the interactive and integrative effects of multiple RAAS polymorphisms on BP at rest and during behavioral stress in a normotensive population. A total of 920 young whit... | ['Adolescent', 'Adult', 'African Continental Ancestry Group', 'Alanine', 'Aldosterone', 'Angiotensinogen', 'Blood Pressure', 'Child', 'Chromosome Mapping', 'European Continental Ancestry Group', 'Female', 'Gene Frequency', 'Genetic Variation', 'Glycine', 'Humans', 'Male', 'Methionine', 'Peptidyl-Dipeptidase A', 'Phenot... | 17,116,759 | [['M01.060.057'], ['M01.060.116'], ['M01.686.508.100'], ['D12.125.042'], ['D04.210.500.745.745.654.062', 'D06.472.040.585.353.118'], ['D12.644.456.073.070', 'D12.644.861.020', 'D12.776.811.070', 'D12.776.872.020'], ['E01.370.600.875.249', 'G09.330.380.076'], ['M01.060.406'], ['E05.393.183'], ['M01.686.508.400'], ['G05.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Impact of Durable Ventricular Assist Device Support on Outcomes of Patients with Congenital Heart Disease Waiting for Heart Transplant. | The number of congenital heart disease (CHD) patients with heart failure is expanding. These patients have a high probability of dying while awaiting heart transplant. The potential for durable ventricular assist devices (VAD) to improve waiting list survival in CHD is unknown. We conducted an analysis of the Scientifi... | ['Adult', 'Databases, Factual', 'Female', 'Heart Defects, Congenital', 'Heart Failure', 'Heart Transplantation', 'Heart-Assist Devices', 'Humans', 'Male', 'Registries', 'Retrospective Studies', 'Waiting Lists'] | 31,335,373 | [['M01.060.116'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['C14.280.434'], ['E04.100.376.475', 'E04.928.220.390', 'E04.936.450.475'], ['E04.050.430', 'E07.695.300.300', 'E07.858.082.374.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.9... | ['Named Groups [M]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Aeration tank odour by dimethyl sulphoxide (DMSO) waste in sewage. | Sewage plants can experience dimethyl sulphide (DMS) odour problems by at least one mg/L dimethylsulphoxide (DMSO) waste residue in plant influent, through a DMSO/DMS reduction mechanism. This bench-scale batch study simulates in bottles the role of poor aeration in wastewater treatment on the DMSO/DMS and sulphate/H2S... | ['Biodegradation, Environmental', 'Dimethyl Sulfoxide', 'Models, Chemical', 'Odorants', 'Oxygen', 'Sewage', 'Sulfur', 'Waste Disposal, Fluid', 'Water Pollutants, Chemical', 'Water Pollution', 'Water Purification'] | 17,489,425 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['D02.886.640.150'], ['E05.599.495'], ['G16.500.275.640', 'N06.230.480'], ['D01.268.185.550', 'D01.362.670'], ['D20.944.932.500'], ['D01.268.185.900'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['D27.888.284.903.655'], ['N06.850.460.790'], ['N06.850... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Influence of proximal side mutations on the molecular and electronic structure of cyanomet myoglobin: an 1H NMR study. | A series of proximal side mutants of sperm whale metmyoglobin (metMb) that involves residues which provide hydrogen bonds to the axial His and heme have been prepared, and the CO binding and solution molecular and electronic structure has been investigated by 1H NMR. These include Ser92(F7), whose O gamma serves as a h... | ['Animals', 'Binding Sites', 'Carbon Monoxide', 'Energy Transfer', 'Heme', 'Histidine', 'Hydrogen-Ion Concentration', 'Kinetics', 'Ligands', 'Male', 'Metmyoglobin', 'Mutagenesis, Site-Directed', 'Nuclear Magnetic Resonance, Biomolecular', 'Protons', 'Spermatozoa', 'Whales'] | 9,578,585 | [['B01.050'], ['G02.111.570.120'], ['D01.200.250', 'D01.362.200', 'D01.650.550.250'], ['G01.154.240', 'G02.111.255', 'G02.216'], ['D03.383.129.578.840.500.640.587', 'D03.633.400.909.500.640.587', 'D04.345.783.500.640.587', 'D23.767.727.640.587'], ['D12.125.072.329', 'D12.125.142.308'], ['G02.300'], ['G01.374.661', 'G02... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Modulation of P-glycoprotein activity by glial factors and retinoic acid in an immortalized rat brain microvessel endothelial cell line. | P-glycoprotein (P-gp), a product of the multidrug-resistant (mdr) genes, is expressed in the endothelial cells of the blood-brain barrier (BBB). Effects of glial factors and retinoic acid (RA) on P-gp activity and level were investigated in the immortalized rat brain endothelial cell line RBE4, which expressed immunode... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Animals', 'Astrocytes', 'Blood-Brain Barrier', 'Brain', 'Cell Line', 'Colchicine', 'Culture Media, Conditioned', 'Cyclosporine', 'Dose-Response Relationship, Drug', 'Endothelium, Vascular', 'Glioma', 'Microcirculation', 'Rats', 'Tretinoin', 'Tumor Cells, Cult... | 9,404,823 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['B01.050'], ['A08.637.200', 'A11.650.200'], ['A07.035', 'A08.186.211.035'], ['A08.186.211'], ['A11.251.210... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sources of self-identity among Turkish adolescents. | As part of the International Self-Identity Research Project, this study explored sources of identity among Turkish adolescents. The interview sample consisted of three male and three female high school students in Ankara, Turkey. The results indicated that social, familial, personal, physical, and moral-ethical dimensi... | ['Adolescent', 'Ethnic Groups', 'Female', 'Humans', 'Interpersonal Relations', 'Male', 'Psychology, Adolescent', 'Self Concept', 'Social Identification', 'Turkey'] | 10,658,861 | [['M01.060.057'], ['M01.686.754', 'N01.224.317'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F04.096.628.065'], ['F01.752.747.792'], ['F01.145.813.708'], ['Z01.252.245.500.850']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Multimodal management of arteriovenous malformations of the basal ganglia and thalamus: factors affecting obliteration and outcome. | OBJECTIVE: Arteriovenous malformations (AVMs) of the basal ganglia and thalamus are particularly difficult lesions to treat, accounting for 3%-13% of all AVMs in surgical series and 23%-44% of malformations in radiosurgery series. The goal of this study was to report the results of multimodal management of basal gangli... | ['Adolescent', 'Adult', 'Arteriovenous Fistula', 'Basal Ganglia', 'Combined Modality Therapy', 'Disease Management', 'Female', 'Follow-Up Studies', 'Humans', 'Intracranial Arteriovenous Malformations', 'Male', 'Neurosurgical Procedures', 'Prospective Studies', 'Radiosurgery', 'Retrospective Studies', 'Thalamus', 'Treat... | 30,117,771 | [['M01.060.057'], ['M01.060.116'], ['C14.240.850.750.147', 'C14.240.850.984.750', 'C14.907.150.125', 'C14.907.933.555', 'C16.131.240.850.750.125', 'C23.300.575.950.250'], ['A08.186.211.200.885.287.249'], ['E02.186'], ['N04.590.607'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.35... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Work and life: the end of the zero-sum game. | Most companies view work and personal life as competing priorities in a zero-sum game, in which a gain in one area means a loss in the other. From this traditional perspective, managers decide how their employees' work and personal lives should intersect and often view work-life programs as just so much social welfare.... | ['Commerce', 'Humans', 'Job Satisfaction', 'Life Style', 'Organizational Culture', 'Organizational Innovation', 'Personal Satisfaction', 'Personnel Management', 'Quality of Life', 'United States', 'Workload'] | 10,187,242 | [['J01.219'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.784.692.425'], ['F01.829.458'], ['N04.452.606'], ['N04.452.610'], ['F01.145.677'], ['N04.452.677'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['Z01.107.567.875'], ['I03.946.225.500', 'N04.452.677.650.500']] | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Voltage-dependent nitrendipine binding to cardiac sarcolemmal vesicles. | The binding of the calcium channel antagonist [3H]nitrendipine (3[H]Ntd) to purified bovine cardiac sarcolemmal vesicles was examined at different membrane potentials. The vesicles were loaded with 150 mM K and exposed to a range of external K concentrations to induce negative internal membrane potentials using N-methy... | ['Animals', 'Cattle', 'Heart', 'In Vitro Techniques', 'Membrane Potentials', 'Nitrendipine', 'Sarcolemma', 'Sodium-Potassium-Exchanging ATPase'] | 3,039,342 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A07.541'], ['E05.481'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['D03.383.725.203.590'], ['A11.284.149.707'], ['D08.811.277.040.025.314.750', 'D12.776.157.530.450.162.780', 'D12.776.157.530.450.250.880', 'D12.776.157.530.813.750', 'D12.776.543.5... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Presence of c.3956delC mutation in familial adenomatous polyposis patients from Brazil. | AIM: To characterize APC gene mutations and correlate them with patient phenotypes in individuals diagnosed with familial adenomatous polyposis (FAP) in northern Brazil.METHODS: A total of 15 individuals diagnosed with FAP from 5 different families from the north of Brazil were analyzed in this study. In addition to pa... | ['Adenomatous Polyposis Coli', 'Adenomatous Polyposis Coli Protein', 'Adolescent', 'Adult', 'Biomarkers, Tumor', 'Brazil', 'DNA Mutational Analysis', 'Female', 'Genetic Association Studies', 'Genetic Predisposition to Disease', 'Germ-Line Mutation', 'Heredity', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Male',... | 26,309,368 | [['C04.557.470.035.215.100', 'C04.588.274.476.411.307.089', 'C04.700.100', 'C06.301.371.411.307.090', 'C06.405.249.411.307.090', 'C06.405.469.158.356.090', 'C06.405.469.491.307.090', 'C06.405.469.578.249', 'C16.320.700.100'], ['D05.500.117.249', 'D12.776.220.040', 'D12.776.476.081.249', 'D12.776.624.776.010'], ['M01.06... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Microwave-stimulated fixation for electron microscopy using a domestic microwave oven. | We investigated microwave-stimulated fixation of tissues for transmission electron microscopy using a domestic microwave oven operating at a frequency of 2.45 GHz with an output power of 500W. Microwave-stimulated fixation, in 4% glutaraldehyde, of fresh rat kidney, liver, heart and brain tissues was compared to conven... | ['Animals', 'Fixatives', 'Histological Techniques', 'Humans', 'Microscopy, Electron', 'Microwaves', 'Rats'] | 2,090,887 | [['B01.050'], ['D27.720.355'], ['E01.370.225.750', 'E05.200.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402', 'E05.595.402'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preterm delivery: correlations of fetal growth and placental pathology. | The present study of 466 consecutive liveborn preterm singleton deliveries included 238 cases of spontaneous preterm labor and delivery, 175 cases with premature rupture of membranes, 13 cases of nonhypertensive abruption, 18 cases of preeclampsia, and 22 cases of placenta previa. Placental infarction, chronic villitis... | ['Birth Weight', 'Embryonic and Fetal Development', 'Female', 'Fetal Growth Retardation', 'Humans', 'Infant, Newborn', 'Obstetric Labor, Premature', 'Placenta', 'Placenta Diseases', 'Pregnancy', 'Retrospective Studies'] | 1,575,840 | [['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['G07.345.500.325', 'G08.686.784.170'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C13.703.420.491... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Synaptic depression and neuronal loss in transiently acidic hippocampal slice cultures. | Acidosis is a rapid and inevitable event accompanying cerebral ischemia or trauma. We used hippocampal slice cultures to examine an immediate effect of acidosis, synaptic depression; and a delayed effect, neuronal loss. Exposure to low bicarbonate artificial cerebral spinal fluid (aCSF), pH 6.70 for 30 min at 32 degree... | ['Acidosis', 'Animals', 'Bicarbonates', 'Buffers', 'Cell Count', 'Culture Techniques', 'Excitatory Postsynaptic Potentials', 'Hippocampus', 'Hydrogen-Ion Concentration', 'Lactic Acid', 'Rats', 'Rats, Sprague-Dawley'] | 11,033,097 | [['C18.452.076.176'], ['B01.050'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['D27.720.470.280'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['E05.481.500'], ['G04.580.887.249', 'G07.265.675.887.249', 'G07.265.880.750.199', 'G11.561.570.918.249', 'G11.561.830.750.199'], ['A08.186.21... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peripartum myocardial infarction associated with coronary spasm and acquired protein S deficiency: A case report. | RATIONALE: Coronary angiography (CAG) findings of acute myocardial infarction (AMI) in pregnant women are characterized by a high incidence of normal coronary arteries. This is the first report of AMI with normal coronary arteries during pregnancy, showing coronary spasm and pregnancy-related acquired protein S (PS) de... | ['Adult', 'Coronary Vasospasm', 'Female', 'Humans', 'Myocardial Infarction', 'Peripartum Period', 'Pregnancy', 'Pregnancy Complications, Hematologic', 'Protein S Deficiency'] | 31,770,234 | [['M01.060.116'], ['C14.280.647.250.295', 'C14.907.585.250.295'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['G08.686.701'], ['G08.686.784.769'], ['C13.703.667', 'C15.378.785'], ['C15.378.100.800', 'C15.378.147.890', 'C15.378.9... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Simultaneous confidence intervals for comparing biodiversity indices estimated from overdispersed count data. | Diversity indices might be used to assess the impact of treatments on the relative abundance patterns in species communities. When several treatments are to be compared, simultaneous confidence intervals for the differences of diversity indices between treatments may be used. The simultaneous confidence interval method... | ['Animals', 'Biodiversity', 'Biometry', 'Time Factors'] | 23,401,312 | [['B01.050'], ['G16.500.275.157.049', 'N06.230.124.049'], ['E05.318.740.225', 'N06.850.505.200'], ['G01.910.857']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Pediatric urethral catheter consultations: understanding driving factors. | PURPOSE: Pediatric urethral catheterization is often straightforward. However, it can be challenging and may require urological consultation. Possible critical factors are patient anatomy and comorbidities, and insertion technique. To better understand pediatric catheter consultations, we reviewed our experience.MATERI... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Referral and Consultation', 'Retrospective Studies', 'Urinary Catheterization', 'Urinary Catheters', 'Young Adult'] | 24,231,838 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['N04.452.758.849'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850... | ['Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of extreme natural events on the provision of ecosystem services in a mountain environment: The importance of trail design in delivering system resilience and ecosystem service co-benefits. | A continued supply of ecosystem services (ES) from a system depends on the resilience of that system to withstand shocks and perturbations. In many parts of the world, climate change is leading to an increased frequency of extreme weather events, potentially influencing ES provision. Our study of the effects of an inte... | ['Altitude', 'Biodiversity', 'Climate Change', 'Conservation of Natural Resources', 'Ecosystem', 'Models, Theoretical', 'Parks, Recreational', 'Poland', 'Rain', 'Recreation'] | 26,496,846 | [['G16.500.275.058', 'N06.230.058'], ['G16.500.275.157.049', 'N06.230.124.049'], ['G16.500.175.374'], ['J01.256', 'N06.230.080'], ['G16.500.275.157', 'N06.230.124'], ['E05.599'], ['J03.925.680'], ['Z01.542.248.679'], ['G16.500.175.859', 'G16.500.275.063.725.395', 'G16.500.750.775.450', 'N06.230.300.100.725.450', 'N06.2... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Intuitive statistics by 8-month-old infants. | Human learners make inductive inferences based on small amounts of data: we generalize from samples to populations and vice versa. The academic discipline of statistics formalizes these intuitive statistical inferences. What is the origin of this ability? We report six experiments investigating whether 8-month-old infa... | ['Adult', 'Female', 'Humans', 'Infant', 'Intuition', 'Learning', 'Logic', 'Male', 'Middle Aged', 'Sample Size'] | 18,378,901 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['F02.463.188.675'], ['F02.463.425', 'F02.784.629.529'], ['K01.752.448'], ['M01.060.116.630'], ['E05.318.370.762', 'E05.581.500.902', 'N05.715.360.325.692', 'N06.850.520.445.762']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Primary cutaneous anaplastic large-cell lymphoma with a prolonged erythrodermic prodrome. | Anaplastic large cell lymphoma (ALCL) is a high grade non-Hodgkins lymphoma recognized by the expression of the CD30 marker and by its morphology. We report a patient with a 6-year history of a non-specific erythroderma in whom ALCL developed with rapid and fatal dissemination to the lymph nodes and internal organs. | ['Aged', 'Dermatitis, Exfoliative', 'Female', 'Humans', 'Lymphoma, Large B-Cell, Diffuse', 'Skin', 'Skin Neoplasms'] | 1,532,505 | [['M01.060.116.100'], ['C17.800.174.318', 'C17.800.815.318'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386.480.150.585', 'C15.604.515.569.480.150.585', 'C20.683.515.761.480.150.585'], ['A17.815'], ['C04.588.805', 'C17.800.882']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
á-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. | Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritiona... | ['Amino Acid Transport Systems, Basic', 'Amino Acid Transport Systems, Neutral', 'Animals', 'Cystine', 'Cystinuria', 'Disease Models, Animal', 'Kidney', 'Mice', 'Mice, Knockout', 'Solubility', 'Thioctic Acid', 'Urolithiasis', 'X-Ray Microtomography'] | 28,165,480 | [['D12.776.157.530.200.374', 'D12.776.543.585.200.374'], ['D12.776.157.530.200.500', 'D12.776.543.585.200.500'], ['B01.050'], ['D01.248.497.158.874.390.369', 'D01.875.350.850.150.369', 'D02.886.030.230.369', 'D02.886.520.150.087', 'D12.125.095.369', 'D12.125.119.369', 'D12.125.166.230.369'], ['C12.777.419.815.885.250',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors governing the course of emboli in the therapeutic embolization of cerebral arteriovenous malformations. | Many factors are involved in the therapeutic intra-arterial management of cerebral arteriovenous malformations (AVMs) by embolization. If these factors could be better defined, the suitability of patients for embolization could be more accurately predicted. In 59 embolization procedures, the diameters of feeding arteri... | ['Adult', 'Carotid Arteries', 'Cerebral Angiography', 'Embolization, Therapeutic', 'Humans', 'Intracranial Arteriovenous Malformations', 'Middle Aged', 'Vertebral Artery'] | 424,572 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxidase-mediated glutathione conjugation of benzo[a]pyrene-7,8-dihydrodiol is enhanced by benzo[a]pyrene phenols in vitro. | We reported previously that glutathione (GSH) is oxidized by peroxidases to a thiyl radical that can react with a number of chemicals, including the penultimate carcinogenic metabolite benzo[a]pyrene-7,8-dihydrodiol (7,8-B[a]PD), to give GSH conjugates. Here, we report that phenolic metabolites of benzo[a]pyrene (B[a]P... | ['Benzo(a)pyrene', 'Cytochrome P-450 Enzyme System', 'Dihydroxydihydrobenzopyrenes', 'Free Radicals', 'Glutathione', 'Peroxidases', 'Phenols'] | 1,576,701 | [['D02.455.426.559.847.799.306.300', 'D04.615.799.306.300'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['D02.455.426.559.847.799.306.400', 'D04.615.799.306.400'], ['D01.339', 'D02.389'], ['D12.644.456.448'], ['D08.811.682.732'], ['D02.455.426.559.389.657']] | ['Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Occurrence of a DNA sequence of a non-retro RNA virus in a host plant genome and its expression: evidence for recombination between viral and host RNAs. | This study demonstrates that sequences homologous to those of the non-retro RNA virus (Potato virus Y; PVY) are integrated into the genome of several grapevine varieties. The integrated PVY-coat-protein-like cistron is expressed in the grapevine as indicated by Southern and Western blot analyses as well as by RNase pro... | ['Amino Acid Sequence', 'Base Sequence', 'DNA Primers', 'DNA, Viral', 'Genome, Plant', 'Molecular Sequence Data', 'Plants', 'Potyvirus', 'RNA, Plant', 'RNA, Viral', 'Recombination, Genetic', 'Vitis'] | 15,680,426 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.568'], ['G05.360.340.365'], ['L01.453.245.667'], ['B01.650'], ['B04.715.464.600', 'B04.715.635.600', 'B04.820.578.782.600'], ['D13.444.735.635... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Blue cone monochromatism. | Blue cone monochromatism (BCM) is a subtype of achromatopsia in which the blue cone mechanism predominates. Each of the four patients in this study had BCM proven by their having peak spectral sensitivities in the blue region of the visible spectrum (near 440 nm). Clinically, the diagnosis was suspected because of x-li... | ['Child', 'Color Perception Tests', 'Electroretinography', 'Evaluation Studies as Topic', 'Humans', 'Male', 'Nystagmus, Pathologic', 'Pedigree', 'Photic Stimulation', 'Photoreceptor Cells', 'Retinal Diseases', 'Vision Tests', 'Visual Acuity'] | 2,795,409 | [['M01.060.406'], ['E01.370.380.850.150'], ['E01.370.380.225', 'E01.370.405.270'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.292.562.675', 'C11.590.400'], ['E05.393.673'], ['E05.723.729'], ['A08.675.650.850.625', 'A08.675.650.915.937', 'A08.800.950.937', 'A09.371.729.831.625... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Recognizing biological motion and emotions from point-light displays in autism spectrum disorders. | One of the main characteristics of Autism Spectrum Disorder (ASD) are problems with social interaction and communication. Here, we explored ASD-related alterations in 'reading' body language of other humans. Accuracy and reaction times were assessed from two observational tasks involving the recognition of 'biological ... | ['Adult', 'Child', 'Child Development Disorders, Pervasive', 'Emotions', 'Eye Movements', 'Female', 'Humans', 'Light', 'Male', 'Motion'] | 22,970,227 | [['M01.060.116'], ['M01.060.406'], ['F03.625.164'], ['F01.470'], ['G11.427.410.140', 'G14.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['G01.482']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Experience with the Advanced Breast Biopsy Instrumentation (ABBI) system. | BACKGROUND: The Advanced Breast Biopsy Instrumentation (ABBI) System is designed to excise nonpalpable breast lesions under stereotactic control. We report our experience with special regard to the histological evaluation of margins.PATIENTS AND METHODS: Breast biopsies using the ABBI system were performed on 101 patie... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biopsy', 'Breast Neoplasms', 'Carcinoma in Situ', 'Carcinoma, Ductal, Breast', 'Carcinoma, Lobular', 'Female', 'Humans', 'Middle Aged', 'Stereotaxic Techniques'] | 12,530,044 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.240'], ['C04.557.470.200.025.232.500', 'C04.557.470.615.132... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Methodology of the biological risk classification of animal pathogens in Belgium. | Since many micro-organisms are a biological hazard, they have been categorised into risk groups by many countries and organisations and classification lists have been developed. Current classification systems rely on criteria defined by the World Health Organization, which cover the severity of the disease the micro-or... | ['Animal Diseases', 'Animals', 'Bacteria', 'Belgium', 'Communicable Diseases', 'Fungi', 'Humans', 'Parasites', 'Risk Assessment', 'Viruses'] | 21,309,451 | [['C22'], ['B01.050'], ['B03'], ['Z01.542.115'], ['C01.221', 'C23.550.291.531'], ['B01.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.500.714'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['B04']] | ['Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Availability of services for women in outpatient substance abuse treatment: 1995-2000. | Women entering substance abuse treatment have more severe substance abuse problems and more medical and psychiatric comorbidities than men. Research shows that specialized women's services are associated with better retention and outcomes but relatively little is known about their availability nationwide. This study ex... | ['Ambulatory Care', 'Female', 'Health Services Research', 'Humans', 'Reproductive Medicine', 'Social Work', 'Substance Abuse Treatment Centers', 'United States'] | 16,636,905 | [['E02.760.106', 'N02.421.585.106'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.763'], ['I01.880.792', 'N02.421.849'], ['N02.278.035.128.800', 'N02.278.808.930'], ['Z01.107.567.875']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Rhinoplasty with advancing age. Characteristics and management. | The aging nose presents several unique challenges to diagnosis and management. Although classically it presents as a drooping nasal tip secondary to loss of tip support with a relative dorsal hump, there are associated changes in the nasal skin, bony architecture, and airway that mandate consideration. Methods of corre... | ['Aged', 'Aging', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nasal Bone', 'Nasal Cavity', 'Nose', 'Rhinoplasty'] | 8,726,428 | [['M01.060.116.100'], ['G07.345.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A02.835.232.781.324.665', 'A04.531.378'], ['A04.531.449'], ['A01.456.505.733', 'A04.531', 'A09.531'], ['E02.218.755', 'E04.580.392.500', 'E04.680.650']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Interference of clindamycin in skin infection in rabbits caused by suture threads infected with slime-producing S. epidermidis]. | The authors have carried out an experimental study to evaluate the interference of sub-inhibitory concentrations of clindamycin on the adherence of slime producing S. epidermidis to surgical nets and its ability to infect rabbits. 80 rabbits divided into 4 groups, (A, B, C, and D), underwent sham operation of the abdom... | ['Animals', 'Bacterial Adhesion', 'Clindamycin', 'Rabbits', 'Skin Diseases, Infectious', 'Staphylococcal Infections', 'Staphylococcus aureus', 'Staphylococcus epidermidis', 'Sutures'] | 2,282,280 | [['B01.050'], ['G06.099.050'], ['D03.383.773.532.500.125', 'D09.408.471.500.125'], ['B01.050.150.900.649.313.968.700'], ['C01.800', 'C17.800.838'], ['C01.150.252.410.868'], ['B03.300.390.400.800.750.100', 'B03.353.500.750.750.100', 'B03.510.100.750.750.100', 'B03.510.400.790.750.100'], ['B03.300.390.400.800.750.343', '... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A longitudinal study of circulating progesterone, oestradiol, hCG and hPL during pregnancy in type 1 diabetic mothers. | Serum progesterone, oestradiol, human chorionic gonadotrophin (hCG) and human placental lactogen (hPL) were determined serially throughout 27 pregnancies in insulin-dependent diabetic patients from Newcastle (UK), 15 such patients from Stockholm (Sweden) and in 69 normal women having uncomplicated pregnancies. Mean pro... | ['Adult', 'Birth Weight', 'Blood Glucose', 'Chorionic Gonadotropin', 'Diabetes Mellitus, Type 1', 'Estradiol', 'Female', 'Humans', 'Infant, Newborn', 'Longitudinal Studies', 'Organ Size', 'Placenta', 'Placental Lactogen', 'Pregnancy', 'Pregnancy in Diabetics', 'Progesterone', 'Time Factors'] | 2,751,954 | [['M01.060.116'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['D09.947.875.359.448.500'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['C18.452.394.750.124', 'C19.246.267', 'C20.11... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Inhibin A production after gonadotropin stimulus: a new method to detect ovarian tissue in ovotesticular disorder of sex development. | BACKGROUND/AIMS: While laboratory methods for the detection of testicular tissue are well standardized, currently there is no available test to demonstrate the presence of ovarian tissue. We evaluated the effectiveness of gonadal stimulation with luteinizing hormone (LH)/follicle-stimulating hormone (FSH) for the detec... | ['Adolescent', 'Child', 'Child, Preschool', 'Disorders of Sex Development', 'Estradiol', 'Female', 'Follicle Stimulating Hormone', 'Hormones', 'Humans', 'Infant', 'Inhibins', 'Luteinizing Hormone', 'Male', 'Ovary'] | 19,129,714 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C12.706.316', 'C13.351.875.253', 'C16.131.939.316', 'C19.391.119'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['D06.472', 'D27.505.696.399.472'], ['B01.050.1... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Coercive procedures and facilities in Swiss psychiatry. | BACKGROUND: Coercive measures in psychiatry,although in many cases effective in violence management and injury reduction, have been criticised from a consumerist point of view.METHOD: A questionnaire regarding coercive facilities and procedures was dispatched to the charge nurses of 86 acute psychiatric admission wards... | ['Adult', 'Cross-Sectional Studies', 'Female', 'Hospitals, Psychiatric', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Restraint, Physical', 'Risk Management', 'Switzerland', 'Violence'] | 12,148,079 | [['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N02.278.421.556.508'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.116.630'], ['E02.085.700'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Immunization of rhesus macaques with a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine elicits protective antibody response against simian human immunodeficiency virus of R5 phenotype. | The immunogenicity of a poylvalent HIV-1 vaccine comprised of Env antigens from primary R5 isolates was evaluated in rhesus macaques. DNA vaccines encoding four Env antigens from multiple HIV-1 subtypes and HIV-1 Gag antigen from a single subtype elicited a persistent level of binding antibodies to gp120 from multiple ... | ['AIDS Vaccines', 'Animals', 'Antibodies, Viral', 'Gene Products, gag', 'HIV Envelope Protein gp120', 'HIV-1', 'Humans', 'Immunity, Cellular', 'Immunization Schedule', 'Immunization, Secondary', 'Macaca mulatta', 'Neutralization Tests', 'Phenotype', 'Simian Acquired Immunodeficiency Syndrome', 'Simian Immunodeficiency ... | 16,460,776 | [['D20.215.894.899.050'], ['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['D12.776.775.330', 'D12.776.964.775.350', 'D12.776.964.970.600.850.350'], ['D12.776.964.775.325.164.249', 'D12.776.964.775.562.500.500', 'D12.776.964.970.880.325.164.249', 'D23.050.327.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Push enteroscopic cauterization: long-term follow-up of 83 patients with bleeding small intestinal angiodysplasia. | BACKGROUND: This study assessed the long-term effectiveness of push enteroscopic cauterization of bleeding intestinal angiodysplasia.METHODS: We retrospectively reviewed the clinical course of patients who underwent push and sonde enteroscopy for obscure gastrointestinal bleeding and were diagnosed with intestinal angi... | ['Aged', 'Aged, 80 and over', 'Angiodysplasia', 'Cautery', 'Endoscopy, Digestive System', 'Female', 'Follow-Up Studies', 'Gastrointestinal Hemorrhage', 'Humans', 'Jejunal Diseases', 'Male', 'Middle Aged', 'Retrospective Studies', 'Treatment Outcome'] | 8,781,937 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.907.075'], ['E02.154', 'E04.014.170'], ['E01.370.372.250', 'E01.370.388.250.250', 'E04.210.240', 'E04.502.250.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C06.405.227', 'C23.550.414.788'], ['B01.050.150.900.649.3... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bone fragment union and remodeling after arthroscopic bony bankart repair for traumatic anterior shoulder instability with a glenoid defect: influence on postoperative recurrence of instability. | BACKGROUND: Although good clinical outcomes have been reported after arthroscopic bony Bankart repair, the extent of bone union is still unclear.PURPOSE: To investigate bone union after arthroscopic bony Bankart repair and its influence on postoperative recurrence of instability.STUDY DESIGN: Cohort study; Level of evi... | ['Arthroplasty', 'Arthroscopy', 'Bone Diseases', 'Bone Remodeling', 'Cohort Studies', 'Female', 'Glenoid Cavity', 'Humans', 'Joint Instability', 'Male', 'Middle Aged', 'Postoperative Complications', 'Recurrence', 'Scapula', 'Shoulder Dislocation', 'Shoulder Joint', 'Tomography, X-Ray Computed', 'Treatment Outcome', 'Wo... | 25,748,472 | [['E04.555.110', 'E04.680.101'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['C05.116'], ['G11.427.213', 'G16.762.150'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['A02.835.232.087.783.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.521'], ['M01.060... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Development, validation and application of an ultra high performance liquid chromatographic-tandem mass spectrometric method for the simultaneous detection and quantification of five different classes of veterinary antibiotics in swine manure. | In this study, a fast, simple and selective ultra high performance liquid chromatographic-tandem mass spectrometric (UHPLC-MS/MS) method for the simultaneous detection and quantification of colistin, sulfadiazine, trimethoprim, doxycycline, oxytetracycline and ceftiofur and for the detection of tylosin A in swine manur... | ['Animals', 'Anti-Bacterial Agents', 'Chemistry Techniques, Analytical', 'Chromatography, High Pressure Liquid', 'Manure', 'Reproducibility of Results', 'Swine', 'Tandem Mass Spectrometry'] | 26,739,912 | [['B01.050'], ['D27.505.954.122.085'], ['E05.196'], ['E05.196.181.400.300'], ['D20.601'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['B01.050.150.900.649.313.500.880'], ['E05.196.566.880']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Characterization of a CD40-dominant inhibitory receptor mutant. | CD40 is an important mediator of immune and inflammatory responses. It is a costimulatory molecule for B cell proliferation and survival. Blockade of CD40 has been shown to induce tolerance and its role in other pathogenic conditions has led to the proposal that CD40 inhibition could be valuable therapeutically. As a f... | ['Binding Sites', 'CD40 Antigens', 'Gene Deletion', 'Genes, Dominant', 'Humans', 'Immunophenotyping', 'Immunosuppressive Agents', 'Jurkat Cells', 'NF-kappa B', 'Proteins', 'Receptors, Tumor Necrosis Factor', 'Signal Transduction', 'TNF Receptor-Associated Factor 2', 'Transfection', 'Tumor Cells, Cultured'] | 11,714,804 | [['G02.111.570.120'], ['D12.776.465.750', 'D12.776.543.750.705.852.760.097', 'D23.050.301.264.051.140', 'D23.101.100.150.140'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.360.340.024.340.240', 'G05.420.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812.447', 'E05.200.812.447', 'E05.478.594... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antidepressant-like effects of standardized gypenosides: involvement of brain-derived neurotrophic factor signaling in hippocampus. | RATIONALE: Gypenosides have been reported to produce neuroprotective effects and increase monoamine neurotransmitter levels in the brain.OBJECTIVE: Considering that depression is involved in monoamine reduction, this study evaluated the antidepressant-like effects of gypenosides in mice exposed to chronic unpredictable... | ['Animals', 'Antidepressive Agents', 'Brain-Derived Neurotrophic Factor', 'Carbazoles', 'Depression', 'Disease Models, Animal', 'Enzyme Inhibitors', 'Extracellular Signal-Regulated MAP Kinases', 'Fluoxetine', 'Gynostemma', 'Hippocampus', 'Indole Alkaloids', 'Male', 'Mice', 'Phosphorylation', 'Plant Extracts', 'Proto-On... | 27,385,417 | [['B01.050'], ['D27.505.954.427.700.122'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['D03.633.100.473.144', 'D03.633.300.148'], ['F01.145.126.350'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D27.505.519.389'], ['D08.811.913.696.620.682.700.567.249', 'D12.644.360.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
Source of truth: where is it in your documentation? | In summary, a variety of documentation sources may affect reporting accuracy as well as bedside efficiency. the successful process to streamline documentation at HealthEast requires clinicians from the bedside, informatics staff, and the quality office to ensure an efficient and thoughtful implementation. As hospitals ... | ['Documentation', 'Medical Records Systems, Computerized', 'Nursing Records', 'United States'] | 22,036,899 | [['L01.453.245'], ['E05.318.308.940.968.625', 'L01.313.500.750.300.695', 'N04.452.859.564.650', 'N05.715.360.300.715.500.530', 'N06.850.520.308.940.968.625'], ['E05.318.308.940.984', 'L01.399.250.900.984', 'N04.452.859.675', 'N05.715.360.300.715.550', 'N06.850.520.308.940.984'], ['Z01.107.567.875']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Localization of a second SigH promoter in the Bacillus subtilis sigA operon and regulation of dnaE expression by the promoter. | The presence of a second SigH promoter in the sigA operon of Bacillus subtilis was demonstrated by use of a promoter probe plasmid, a sigH deletion mutant, primer extension studies, and in vitro transcription with E sigma H holoenzyme. Both SigH promoters were expressed at low levels even during the growth phase but we... | ['Bacillus subtilis', 'Base Sequence', 'Chromosome Deletion', 'Gene Expression Regulation, Bacterial', 'Molecular Sequence Data', 'Mutation', 'Operon', 'Plasmids', 'Promoter Regions, Genetic', 'Protein Biosynthesis', 'RNA, Bacterial', 'Restriction Mapping', 'Sequence Homology, Nucleic Acid', 'Sigma Factor', 'Transcript... | 1,698,762 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Robustness index score: a new stability parameter for designing robustness into biologic formulations. | Formulation robustness is critical to product quality. A challenge in designing robustness into biologic formulations is the absence of one global parameter, which allows equitable comparison across formulations and quality measures. The new measure introduced here derived from accelerated testing data allows for the d... | ['Biological Products', 'Chemistry, Pharmaceutical', 'Kinetics', 'Models, Theoretical', 'Proteins'] | 21,976,016 | [['D20.215'], ['H01.158.703.007', 'H01.181.466'], ['G01.374.661', 'G02.111.490'], ['E05.599'], ['D12.776']] | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Topological and functional discovery in a gene coexpression meta-network of gastric cancer. | Gastric cancer is a leading cause of global cancer mortality, but comparatively little is known about the cellular pathways regulating different aspects of the gastric cancer phenotype. To achieve a better understanding of gastric cancer at the levels of systems topology, functional modules, and constituent genes, we a... | ['Cluster Analysis', 'Gene Expression Profiling', 'Group II Phospholipases A2', 'Humans', 'Oligonucleotide Array Sequence Analysis', 'Phospholipases A', 'Receptor, EphB2', 'Stomach Neoplasms'] | 16,397,236 | [['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.393.332'], ['D08.811.277.352.100.680.750.937.750.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['D08.811.277.352.100.680.750'], ['D08.811.913.696.620.682.725.400.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Further experience in argon laser therapy for cutaneous lesions. | A review of over 350 cases of cutaneous lesions, principally cases of port-wine stains, treated by argon laser in the last six years is presented. Success rates of 45-50% have been obtained and the complication rate has been greatly reduced by careful selection of patients and modification of the dosage used based on e... | ['Argon', 'Hemangioma', 'Humans', 'Laser Therapy', 'Nevus, Pigmented', 'Skin Neoplasms', 'Telangiectasis'] | 2,333,812 | [['D01.268.613.050', 'D01.362.641.113'], ['C04.557.645.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['C04.557.665.560.615'], ['C04.588.805', 'C17.800.882'], ['C14.907.823']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Changes in eye growth produced by drugs which affect retinal ON or OFF responses to light. | The interaction between drugs which affect ON and OFF responses to light and ocular growth was investigated in 154 eyes of newly-hatched chicks raised with normal vision or monocular occlusion with regular intravitreal injections of APB (2-amino-4 phosphonobutyric acid) or PDA (cis 2,3-piperidine-dicarboxylic acid). Th... | ['Aminobutyrates', 'Animals', 'Electroretinography', 'Excitatory Amino Acid Agonists', 'Eye', 'Female', 'Light', 'Male', 'Pipecolic Acids', 'Refractometry', 'Retina', 'Vitreous Body'] | 8,773,935 | [['D02.241.081.114.500', 'D12.125.190'], ['B01.050'], ['E01.370.380.225', 'E01.370.405.270'], ['D27.505.519.625.190.200', 'D27.505.696.577.190.200'], ['A01.456.505.420', 'A09.371'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['D03.066.758', 'D03.383.621.758'], ['E05.196.808', 'H01.671... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Contributions of individual syndromes to global psychopathology ratings for mental health and substance abuse patients. | Used the SCL-90 Analogue to rate nine psychiatric syndromes-and overall psychopathology in 1,046 mental health and 809 substance abuse patients admitted to a large metropolitan, community mental health center. Stepwise multiple regressions of the nine syndrome ratings on the global psychopathology ratings for each samp... | ['Adult', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Psychological Tests', 'Psychometrics', 'Substance-Related Disorders'] | 7,068,890 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F04.711'], ['F04.711.780'], ['C25.775', 'F03.900']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Compliance with surveillance recommendations for foregut subepithelial tumors is poor: results of a prospective multicenter study. | BACKGROUND: American Gastroenterological Association guidelines recommend performing EUS to characterize subepithelial lesions (SELs) discovered on upper endoscopy (EGD), followed by surveillance if no high-risk features are identified. However, limited data are available on the impact of and compliance with surveillan... | ['Aged', 'Disease Progression', 'Endoscopy, Gastrointestinal', 'Endosonography', 'Esophageal Neoplasms', 'Female', 'Gastrointestinal Stromal Tumors', 'Guidelines as Topic', 'Humans', 'Incidental Findings', 'Leiomyoma', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Patient Compliance', 'Prospective Studies', 'Registri... | 25,660,977 | [['M01.060.116.100'], ['C23.550.291.656'], ['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04.210.240.250', 'E04.502.250.250.250'], ['E01.370.350.850.280'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['C04.557.450.565.370', 'C06.301.371.308', 'C06.405.249.3... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Severe traumatic oculo-orbital displacement. Diagnosis and secondary treatment. | We have treated 12 patients with severe oculo-orbital trauma during the past 3 years. The structural problems, produced by disruption or displacement of the orbital cone, were treated effectively (and, on occasion, preferentially) with onlay bone grafts. For an effective correction, we advise radical mobilization of th... | ['Adult', 'Bone Transplantation', 'Child, Preschool', 'Eye Injuries', 'Facial Injuries', 'Female', 'Humans', 'Male', 'Orbit', 'Transplantation, Autologous'] | 320,612 | [['M01.060.116'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['M01.060.406.448'], ['C10.900.300.284.250', 'C11.297', 'C26.915.300.425.250'], ['C10.900.300.284', 'C26.915.300.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.690'], ['E04.936.664']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The impact of primary hyperparathyroidism on the oral cavity. | CONTEXT: Primary hyperparathyroidism (HPT) is a systemic disease causing bone loss. Periodontal disease is a local inflammatory disease characterized by alveolar bone loss. The older literature records that HPT is associated with loss of radicular lamina dura and brown tumors of the bone, but contemporary studies are l... | ['Adult', 'Aged', 'Bone Density', 'Calcium', 'Case-Control Studies', 'Cross-Sectional Studies', 'Female', 'Humans', 'Hyperparathyroidism, Primary', 'Male', 'Middle Aged', 'Parathyroid Hormone', 'Periodontal Diseases', 'Radiography', 'Statistics, Nonparametric', 'Tooth Loss'] | 16,822,829 | [['M01.060.116'], ['M01.060.116.100'], ['G11.427.100'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Impact of mass spectrometry by MALDI-TOF MS for the rapid identification of aerobic and anaerobic bacteria of clinical importance]. | BACKGROUND: MALDI-TOF MS (Matrix Assisted Laser Desorption Ionization -Time of Flight Mass Spectrometry) technology, recently introduced in the microbiology laboratory has proven to be a precise and rapid method for bacterial identification.OBJECTIVE: To evaluate the performance, costs associated and turnaround time of... | ['Bacteria, Aerobic', 'Bacteria, Anaerobic', 'Bacterial Typing Techniques', 'Costs and Cost Analysis', 'DNA, Bacterial', 'DNA, Ribosomal', 'Humans', 'RNA, Ribosomal, 16S', 'Reproducibility of Results', 'Sequence Analysis, DNA', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'Time Factors'] | 23,677,152 | [['B03.120'], ['B03.130'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['N03.219.151'], ['D13.444.308.212'], ['D13.444.308.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.444.735.686.670'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.393.760.700'], ['E05... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Patient perspectives on the integration of an intensive online behavioral weight loss intervention into primary care. | OBJECTIVE: To examine patients' perception of how a referral-based online lifestyle intervention contributed to primary care medicine.METHODS: We invited 50 adults to complete a semi-structured interview after a 1-year online behavioral weight loss intervention (average weight change: -4.79 kg). We developed an iterati... | ['Behavior Therapy', 'Data Collection', 'Directive Counseling', 'Female', 'Health Education', 'Humans', 'Internet', 'Life Style', 'Male', 'Middle Aged', 'Obesity', 'Patient Satisfaction', 'Preventive Medicine', 'Primary Health Care', 'Statistics as Topic', 'Weight Loss'] | 21,459,256 | [['F04.754.137'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['F02.784.176.279', 'F04.408.413.349', 'N02.421.461.363.349'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['F01.829.458'], ['M01.060.116.630'], ['C18.654.726.500', '... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occ... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Soluble endoglin as a second-trimester marker for preeclampsia. | OBJECTIVE: The objective of this investigation was to characterize soluble endoglin (sEng) concentrations in second-trimester serum of women who either develop preeclampsia or have a normal pregnancy.STUDY DESIGN: Single second-trimester serum samples obtained from healthy, nonsmoking women who subsequently developed s... | ['Adult', 'Antigens, CD', 'Biomarkers', 'Case-Control Studies', 'Endoglin', 'Female', 'Gestational Age', 'Humans', 'Pre-Eclampsia', 'Pregnancy', 'Pregnancy Trimester, Second', 'Receptors, Cell Surface', 'Signal Transduction', 'Transforming Growth Factor beta'] | 17,689,640 | [['M01.060.116'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.101'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D12.776.543.750.250'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.703.395.249'], ['G08.686.784.769'], ['G08.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Identification of non-host semiochemicals for the brown dog tick, Rhipicephalus sanguineus sensu lato (Acari: Ixodidae), from tick-resistant beagles, Canis lupus familiaris. | Studies have shown that the brown dog tick, Rhipicephalus sanguineus sensu lato, when fed on the beagle breed of dog, Canis lupus familiaris, development negatively affected in comparison with tick development after feeding on the English cocker spaniel breed. Thus leading to the suggestion that beagle dogs are be tick... | ['Animals', 'Behavior, Animal', 'Disease Susceptibility', 'Dog Diseases', 'Dogs', 'Female', 'Host-Parasite Interactions', 'Pheromones', 'Rhipicephalus sanguineus', 'Tick Infestations'] | 26,103,925 | [['B01.050'], ['F01.145.113'], ['C23.550.291.687', 'G07.100.250'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['G16.527.200.400'], ['D23.641'], ['B01.050.500.131.166.132.832.400.712.700'], ['C01.610.858.211.857']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Caf?-au-lait macules and pediatric malignancy caused by biallelic mutations in the DNA mismatch repair (MMR) gene PMS2. | A 14-year-old male presented with a T4 sigmoid adenocarcinoma, <10 colonic adenomas and multiple caf?-au-lait macules. Family history was not suggestive of a dominant hereditary form of colorectal cancer. Evaluation of the tumor revealed abnormal immunohistochemical staining of the PMS2 protein and high frequency micro... | ['Adenosine Triphosphatases', 'Adolescent', 'Alleles', 'Cafe-au-Lait Spots', 'Colorectal Neoplasms, Hereditary Nonpolyposis', 'DNA Mismatch Repair', 'DNA Repair Enzymes', 'DNA-Binding Proteins', 'Germ-Line Mutation', 'Humans', 'Male', 'Mismatch Repair Endonuclease PMS2', 'Mutation, Missense', 'Pedigree'] | 18,273,873 | [['D08.811.277.040.025'], ['M01.060.057'], ['G05.360.340.024.340.030'], ['C17.800.621.250', 'C23.888.885.250'], ['C04.588.274.476.411.307.190', 'C04.700.250', 'C06.301.371.411.307.190', 'C06.405.249.411.307.190', 'C06.405.469.158.356.190', 'C06.405.469.491.307.190', 'C16.320.700.250', 'C18.452.284.255'], ['G02.111.222.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Repurposing existing drugs for new AMPK activators as a strategy to extend lifespan: a computer-aided drug discovery study. | Dietary restriction is one of the several ways which could putatively extend organisms' lifespan, ranging from Saccharomyces cerevisiae to rodents, by activating the AMP-activated protein kinase (AMPK), an ATP/AMP sensor. Extensive researches have shown that aging reduces sensibility of AMPK and eventually causes energ... | ['Adenylate Kinase', 'Animals', 'Catalytic Domain', 'Computer-Aided Design', 'Drug Design', 'Drug Discovery', 'Drug Evaluation, Preclinical', 'Drug Repositioning', 'Enzyme Activation', 'Humans', 'Hydrogen Bonding', 'Ligands', 'Longevity', 'Molecular Docking Simulation', 'Molecular Dynamics Simulation', 'United States',... | 29,335,817 | [['D08.811.913.696.650.025'], ['B01.050'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['L01.224.108.150', 'L01.296.110.150'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['E05.290.750', 'E05.337.550'], ['E05.290.875'], ['G02.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Neurological improvement during bioartificial liver sessions in patients with acute liver failure awaiting transplantation. | BACKGROUND: Brain edema is the main cause of death in acute liver failure patients awaiting transplantation. We assessed the HepatAssist 2000, a liver-assist system containing porcine hepatocytes, as a bridge to transplantation in patients with acute liver failure.METHODS: Thirteen patients suffering from acute liver f... | ['Adolescent', 'Adult', 'Brain', 'Female', 'Hemodynamics', 'Humans', 'Intracranial Pressure', 'Liver', 'Liver Failure, Acute', 'Liver, Artificial', 'Male', 'Middle Aged'] | 11,821,741 | [['M01.060.057'], ['M01.060.116'], ['A08.186.211'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.561.170.505'], ['A03.620'], ['C06.552.308.500.750'], ['E07.858.082.620'], ['M01.060.116.630']] | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
High parental age is associated with sporadic hereditary retinoblastoma: the Dutch retinoblastoma register 1862-1994. | We wished to determine the influence of parental age at the birth of a retinoblastoma patient on the risk of sporadic hereditary retinoblastoma. The parental age at birth of 941 patients of the Dutch retinoblastoma register (1862-1994) was identified and compared between sporadic hereditary and nonhereditary patients. ... | ['Adult', 'Cohort Studies', 'Eye Neoplasms', 'Female', 'Genes, Retinoblastoma', 'Humans', 'Male', 'Maternal Age', 'Netherlands', 'Paternal Age', 'Registries', 'Retinoblastoma', 'Risk'] | 8,682,494 | [['M01.060.116'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C04.588.364', 'C11.319'], ['G05.360.340.024.340.375.249.400', 'G05.360.340.024.340.415.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.560', 'N05.715.350.075.550', 'N06.850.490.250.550'], ['Z01.542.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Stability of platelet surface antigens during storage. | We measured changes in A, B, 2H, PlA1, and HLA Class I antigens on human platelets stored as routine platelet concentrates (PCs) in 50 to 60 ml of citrate-phosphate-dextrose-adenine (CPDA-1) plasma in polyolefin (PL 732) bags at 22 degrees C with continuous cartwheel rotation. Samples were obtained at 1, 3, 5, and 10 d... | ['Antibodies, Monoclonal', 'Antigens, Surface', 'Blood Platelets', 'Blood Preservation', 'Drug Stability', 'Humans'] | 4,071,601 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301'], ['A11.118.188', 'A15.145.229.188'], ['E02.792.833.230', 'E05.760.833.230'], ['E05.916.330'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hereditary long QT syndrome in pregnancy: antenatal and intrapartum management options. | Long QT syndrome is a rare but severe cardiac arrhythmia. We report the antenatal and intrapartum management of a primigravida carrying the hereditary form of the disease and specifically the Romano-Ward syndrome. A multidisciplinary approach and close obstetric surveillance are mandatory for a good maternal and perina... | ['Adult', 'Cesarean Section', 'Electrocardiography', 'Female', 'Humans', 'Infant, Newborn', 'Long QT Syndrome', 'Pregnancy', 'Pregnancy Complications, Cardiovascular', 'Pregnancy Outcome', 'Prenatal Care'] | 17,674,248 | [['M01.060.116'], ['E04.520.252.500'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C14.280.067.565', 'C14.280.123.625', 'C16.131.240.400.715', 'C23.550.073.547'], ['G08.686.784.769'], ['C13.703.634', 'C14.583'], ['E01.789.700', 'G08.686.784.769.496... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effort-limited treadmill walk test: reliability and validity in subjects with postpolio syndrome. | OBJECTIVE: To determine the reliability and construct validity of an effort-limited treadmill walk test to measure functional ability in subjects with postpolio syndrome in an outpatient postpolio clinic.DESIGN: Functioning and distance walked on a treadmill to a Borg "hard" effort level were measured three times, a we... | ['Adult', 'Aged', 'Exercise Test', 'Female', 'Health Status Indicators', 'Humans', 'Male', 'Middle Aged', 'Pain Measurement', 'Postpoliomyelitis Syndrome', 'Quality of Life', 'Reproducibility of Results'] | 15,277,963 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['E05.318.308.980.438.475', 'N05.715.360.300.800.438.375', 'N06.850.520.308.980.438.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.600.550.324'], ['C01.207.618.750.750', 'C01.925... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
A zebrafish mosaic assay to study mammalian stem cells in real time in vivo. | The differentiation potentials of stem cells have been evaluated by various in vivo and in vitro assays. However, these assays have different limitations hindering efficient study of mammalian stem cells. Here we describe a rapid and powerful mosaic assay to study the differentiation potentials of stem cells in real ti... | ['Animals', 'Animals, Genetically Modified', 'Cell Culture Techniques', 'Cell Differentiation', 'Cell Transdifferentiation', 'Endoderm', 'Mesoderm', 'Mice', 'Mosaicism', 'Neural Stem Cells', 'Stem Cells', 'Zebrafish'] | 27,554,369 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.152'], ['G04.356'], ['A16.504.407'], ['A16.504.660'], ['B01.050.150.900.649.313.992.635.505.500'], ['G05.365.590.175.595'], ['A11.872.653'], ['A11.872'], ['B01.050.150.900.493.200.244.82... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exogenous interferon-alpha and interferon-gamma increase lethality of murine inhalational anthrax. | BACKGROUND: Bacillus anthracis, the etiologic agent of inhalational anthrax, is a facultative intracellular pathogen. Despite appropriate antimicrobial therapy, the mortality from inhalational anthrax approaches 45%, underscoring the need for better adjuvant therapies. The variable latency between exposure and developm... | ['Administration, Inhalation', 'Animals', 'Anthrax', 'Bacillus anthracis', 'Female', 'Humans', 'Interferon-alpha', 'Interferon-gamma', 'Interleukins', 'Lung', 'MAP Kinase Kinase 3', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'STAT1 Transcription Factor', 'Signal Transduction', 'Spleen', 'Spores, Bacterial', 'Survi... | 17,710,136 | [['E02.319.267.050'], ['B01.050'], ['C01.150.252.410.090.072'], ['B03.300.390.400.158.218.151', 'B03.353.500.100.218.151', 'B03.510.100.100.218.151', 'B03.510.415.400.158.218.151', 'B03.510.460.410.158.218.151'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890.250', 'D12.776.467.374.440.890.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Distribution Characteristics and Seasonal Variation of Soil Nutrients in the Mun River Basin, Thailand. | Based on soil sampling data from the dry season and the rainy season, the spatial heterogeneity and spatial pattern of soil nutrients in the Mun River Basin, Thailand, were studied and the seasonal variation in soil nutrients was analyzed using classical statistical methods and geostatistical methods. The soil nutrient... | ['Electric Conductivity', 'Environmental Monitoring', 'Hydrogen-Ion Concentration', 'Nutrients', 'Rivers', 'Seasons', 'Soil', 'Spatial Analysis', 'Thailand'] | 30,142,884 | [['G01.358.500.249.277'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G02.300'], ['G07.203.300.681', 'J02.500.681'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['E05.318... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
International developments in revenues and incomes of general practitioners from 2000 to 2010. | BACKGROUND: The remuneration system of General Practitioners (GPs) has changed in several countries in the past decade. The aim of our study was: to establish the effect of these changes on the revenues and income of GPs in the first decade of the 21st century.METHODS: Annual GP revenue and practice costs were collecte... | ['Europe', 'General Practitioners', 'Health Expenditures', 'Health Policy', 'Humans', 'Income', 'Primary Health Care', 'Remuneration'] | 24,152,337 | [['Z01.542'], ['M01.526.485.810.485', 'N02.360.810.485'], ['N03.219.151.450', 'N05.300.385'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['N04.590.233.727'], ['N01.824.417.605']] | ['Geographicals [Z]', 'Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
A DNA sequence polymorphism in the endoglin gene is not associated with intracranial aneurysm or aneurysmal subarachnoid hemorrhage. | BACKGROUND AND PURPOSE: Endoglin is a member of the transforming growth factor beta family of proteins and plays a central role in vascular growth and development. There have been conflicting reports that polymorphic variation in the endoglin gene is a risk factor for intracranial aneurysms (IAs). We sought to further ... | ['Adult', 'Aged', 'Alleles', 'Aneurysm', 'Antigens, CD', 'Cloning, Molecular', 'DNA', 'Endoglin', 'Female', 'Gene Frequency', 'Genotype', 'Humans', 'Introns', 'Male', 'Middle Aged', 'Mutation', 'Pennsylvania', 'Polymorphism, Genetic', 'Receptors, Cell Surface', 'Reverse Transcriptase Polymerase Chain Reaction', 'Subara... | 15,976,502 | [['M01.060.116'], ['M01.060.116.100'], ['G05.360.340.024.340.030'], ['C14.907.055'], ['D23.050.301.264.035', 'D23.101.100.110'], ['E05.393.220'], ['D13.444.308'], ['D12.776.543.750.250'], ['G05.330'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
The epitope recognized by pan-HLA class I-reactive monoclonal antibody W6/32 and its relationship to unusual stability of the HLA-B27/beta2-microglobulin complex. | A broadly used pan-HLA class I-reactive monoclonal antibody W6/32 is believed to recognize a conformational epitope dependent on association between heavy chains and beta2-microglobulin (beta2m). However, in the present study we report that W6/32 does recognize at least some free HLA class I heavy chains under the part... | ['Animals', 'Antibodies, Monoclonal', 'Cell Line', 'Cells, Cultured', 'Epitopes', 'HLA-B Antigens', 'HLA-B27 Antigen', 'Histocompatibility Antigens Class I', 'Humans', 'Macromolecular Substances', 'Mice', 'Protein Denaturation', 'Sodium Dodecyl Sulfate', 'beta 2-Microglobulin'] | 11,685,454 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A11.251.210'], ['A11.251'], ['D23.050.550'], ['D12.776.395.550.489.500', 'D12.776.543.550.439.500', 'D23.050.301.500.100.500', 'D23.050.301.500.450.380', 'D23.050.705.552.100.500', 'D23.050.705.552.450.380'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid and effective diagnosis of pulmonary tuberculosis with novel and sensitive loop-mediated isothermal amplification (LAMP) assay in clinical samples: a meta-analysis. | In recent years, Loop-mediated isothermal amplification (LAMP) assay has been introduced for the diagnosis of pulmonary tuberculosis (TB). We performed the meta-analysis to establish the overall accuracy of LAMP assay for diagnosing pulmonary TB. Based on comprehensive searches of the pubmed, embase and cochrane databa... | ['Humans', 'Nucleic Acid Amplification Techniques', 'ROC Curve', 'Sensitivity and Specificity', 'Tuberculosis, Pulmonary'] | 24,462,417 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.620'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.700.680', 'N06.850.520.445.800.750'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['C01.15... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Expected utility of voluntary vaccination in the middle of an emergent Bluetongue virus serotype 8 epidemic: a decision analysis parameterized for Dutch circumstances. | In order to put a halt to the Bluetongue virus serotype 8 (BTV-8) epidemic in 2008, the European Commission promoted vaccination at a transnational level as a new measure to combat BTV-8. Most European member states opted for a mandatory vaccination campaign, whereas the Netherlands, amongst others, opted for a volunta... | ['Agriculture', 'Animals', 'Bluetongue', 'Bluetongue virus', 'Cattle', 'Cattle Diseases', 'Computer Simulation', 'Decision Support Techniques', 'Epidemics', 'Female', 'Netherlands', 'Serogroup', 'Vaccination', 'Viral Vaccines'] | 24,768,508 | [['J01.040'], ['B01.050'], ['C01.920.500.125', 'C01.925.081.125', 'C01.925.782.791.315', 'C22.836.120'], ['B04.820.223.719.550.100'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['L01.224.160'], ['E05.245', 'L01.313.500.750.190'], ['N06.850.290.200'], ['Z01.542.651'], ['G05.695.825'], ['E02.095.465.425.400.53... | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Modulation of cortical motor outputs by the symbolic meaning of visual stimuli. | The observation of an action modulates motor cortical outputs in specific ways, in part through mediation of the mirror neuron system. Sometimes we infer a meaning to an observed action based on integration of the actual percept with memories. Here, we conducted a series of experiments in healthy adults to investigate ... | ['Adult', 'Evoked Potentials, Motor', 'Female', 'Hand', 'Humans', 'Male', 'Motor Activity', 'Motor Cortex', 'Neural Pathways', 'Neuropsychological Tests', 'Photic Stimulation', 'Transcranial Magnetic Stimulation', 'Visual Perception', 'Young Adult'] | 20,561,046 | [['M01.060.116'], ['G07.265.216.500.385', 'G11.561.200.500.385'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.632', 'G11.427.410.698'], ['A08.186.211.200.885.287.500.270.548', 'A08.186.211.200.885.287.500.814.624'], ['A08.612'], ['F04.711.513'], ['E05.723.729'], ['E02.621.820'], ['F0... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A chemical and computational approach to comprehensive glycation characterization on antibodies. | Non-enzymatic glycation is a challenging post-translational modification to characterize due to the structural heterogeneity it generates in proteins. Glycation has become increasingly recognized as an important product quality attribute to monitor, particularly for the biotechnology sector, which produces recombinant ... | ['Antibodies, Monoclonal, Murine-Derived', 'Glycosylation', 'Immunoglobulin G', 'Mass Spectrometry', 'Protein Processing, Post-Translational'] | 26,030,340 | [['D12.776.124.486.485.114.224.075', 'D12.776.124.790.651.114.224.075', 'D12.776.377.715.548.114.224.284'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['E05.196.566'], ['G02.111.660.871.790.600', 'G02.111.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of ethidium bromide on DNA loop organisation in human lymphocytes measured by anomalous viscosity time dependence and single cell gel electrophoresis. | The effects of ethidium bromide (EtBr) on human lymphocytes were studied by the method of anomalous viscosity time dependence (AVTD) and by the comet assay. EtBr at low concentrations increased the maximum viscosity and time of radial migration as measured with AVTD at neutral conditions of lysis. A pronounced relaxati... | ['Adult', 'Chromatin', 'DNA', 'Dose-Response Relationship, Drug', 'Electrophoresis', 'Ethidium', 'Female', 'Humans', 'Lymphocytes', 'Male', 'Middle Aged', 'Mutagenicity Tests', 'Viscosity'] | 10,434,054 | [['M01.060.116'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['D13.444.308'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.196.401', 'E05.301.300'], ['D03.633.300.633.416'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Shape-Preserved Transformation of Biological Cells into Synthetic Hydrogel Microparticles. | The synthesis of materials that can mimic the mechanical, and ultimately functional, properties of biological cells can broadly impact the development of biomimetic materials, as well as engineered tissues and therapeutics. Yet, it is challenging to synthesize, for example, microparticles that share both the anisotropi... | ['Biomimetic Materials', 'Cell Shape', 'Cells, Cultured', 'Cytological Techniques', 'Elastic Modulus', 'HeLa Cells', 'Humans', 'Hydrogels', 'Silicon Dioxide', 'Synthetic Biology'] | 32,627,427 | [['J01.637.087'], ['G04.320'], ['A11.251'], ['E01.370.225.500', 'E05.200.500', 'E05.242'], ['G01.374.590.605'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D20.280.320.375', 'D26.255.165.320.375'], ['D01.578.750', 'D01.650.550.825', 'D01.837.725'], [... | ['Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Nursing a sense of family. | Rosemary Jenkinson was named nurse of the year in 1991 in recognition of her work to establish a community home for children with profound sensory disabilities. Winning the award was a confidence booster and a responsibility, she says. | ['Adolescent', 'Awards and Prizes', 'Child', 'England', 'Family Nursing', 'History, 21st Century', 'Humans', 'Residential Facilities', 'Sensation Disorders'] | 24,299,361 | [['M01.060.057'], ['K01.150'], ['M01.060.406'], ['Z01.542.363.300'], ['H02.478.676.218'], ['K01.400.504.984'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J03.775', 'N02.278.825'], ['C10.597.751', 'C23.888.592.763']] | ['Named Groups [M]', 'Humanities [K]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
APACHE-II score for assessment and monitoring of acute pancreatitis. | The value of the Acute Physiology and Chronic Health Enquiry (APACHE-II) score, the Simplified Acute Physiology score, and the Medical Research Council (MRC) sepsis score were compared with clinical assessment and Ranson and Imrie scores in the evaluation and monitoring of acute pancreatitis in 290 attacks. Attacks wer... | ['Abscess', 'Acute Disease', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Exudates and Transudates', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pancreatic Pseudocyst', 'Pancreatitis', 'Physical Examination', 'Predictive Value of Tests', 'Sensitivity and Specificity'] | 2,568,529 | [['C01.830.025', 'C23.550.470.756.100'], ['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A12.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.182.640.692', 'C06.689.500.692'], ['C06.689.750'], ['E01.370.600'], ['E05.318.370.800.650... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
What is the optimal duration of androgen deprivation therapy in prostate cancer patients presenting with prostate-specific antigen levels > 20 ng/ml? | PURPOSE: To evaluate the optimal duration of androgen deprivation therapy (ADT) in patients with prostate cancer treated with external beam radiotherapy (EBRT), who present with PSA levels > 20 ng/mL.METHODS AND MATERIALS: A total of 307 patients presenting with a PSA > 20 ng/ml were treated with EBRT and ADT. The coho... | ['Aged', 'Androgen Antagonists', 'Gonadotropin-Releasing Hormone', 'Humans', 'Male', 'Prostate-Specific Antigen', 'Prostatic Neoplasms', 'Radiotherapy, Adjuvant', 'Time Factors', 'Treatment Outcome'] | 17,784,982 | [['M01.060.116.100'], ['D06.347.065', 'D27.505.696.399.450.065'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405.740.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.656.300.760.442.750', 'D08.811.277.656.959.350.442.750', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Guidelines for the treatment of anxiety disorders in adults]. | The treatment of anxiety disorders has considerably improved and become more precise over the last two decades, on the basis of empirical results. The evidence of their efficacy is best established for panic disorder, obsessive-compulsive disorder and social phobia. The pharmacological treatment and the psychotherapeut... | ['Adult', 'Anti-Anxiety Agents', 'Anxiety Disorders', 'Evidence-Based Medicine', 'Humans', 'Practice Guidelines as Topic'] | 10,941,305 | [['M01.060.116'], ['D27.505.696.277.950.015', 'D27.505.954.427.210.950.015', 'D27.505.954.427.700.872.015'], ['F03.080'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.700.350.650', 'N05.700.350.650']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
The management of patients undergoing synchronous combined chemotherapy and radiotherapy. | This paper describes the management of patients undergoing synchronous combined chemotherapy and radiotherapy at King's College Hospital. It is based on the experience of treating 96 patients with carcinoma of the head and neck between 1974-1978. A detailed account is given of the method of conducting the treatment. Th... | ['Antineoplastic Agents', 'Carcinoma, Squamous Cell', 'Diagnostic Tests, Routine', 'Diet', 'Drug Administration Schedule', 'Drug Therapy, Combination', 'Head and Neck Neoplasms', 'Humans', 'Stomatitis'] | 7,069,276 | [['D27.505.954.248'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E01.370.395'], ['G07.203.650.240'], ['E02.319.283'], ['E02.319.310'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C07.465.864']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination of buildup and dilution of wastewater effluent in shellfish growing waters through a modified application of super-position. | Since 1925, dilution analysis has been used to minimize pathogenic impacts to bivalve molluscan shellfish growing areas from treated wastewater effluent in the National Shellfish Sanitation Program (NSSP). For over twenty five years, the U.S. Food and Drug Administration (FDA) has recommended a minimum of 1000:1 diluti... | ['Animals', 'Bivalvia', 'Environmental Monitoring', 'Sewage', 'Shellfish', 'Waste Disposal, Fluid', 'Waste Water'] | 27,956,013 | [['B01.050'], ['B01.050.500.644.080'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D20.944.932.500'], ['G07.203.300.600.875.700', 'J02.500.600.875.700'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['D20.944.932', 'N06.850.460.710.865']] | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Evaluations of clinical tobacco cessation interventions in Arab populations: A systematic review. | BACKGROUND AND AIMS: Tobacco smoking is prevalent among Arab smokers. Interventions to support smoking cessation may differ in effectiveness in this population from Western populations usually studied. This review assessed evidence of effectiveness of clinical smoking interventions in Arab smokers.METHODS: A systematic... | ['Arabs', 'Bayes Theorem', 'Behavior Therapy', 'Humans', 'Smoking Cessation', 'Tobacco Use Cessation'] | 30,205,256 | [['M01.686.754.167'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['F04.754.137'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.488.732'], ['F01.145.488.750']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Maximal sniff mouth pressure compared with maximal inspiratory pressure in acute respiratory failure. | Inspiratory muscle strength most often is better reflected by sniff Pes than PImax against occlusion. Furthermore, sniff Pes can be estimated noninvasively by the measurement of sniff Pmo in normal subjects and in patients with respiratory muscle weakness. The aim of this study was to compare sniff Pmo and P.PImax to a... | ['Acute Disease', 'Adult', 'Aged', 'Female', 'Heart Failure', 'Humans', 'Lung Diseases, Obstructive', 'Male', 'Middle Aged', 'Mouth', 'Polyradiculoneuropathy', 'Pressure', 'Pulmonary Ventilation', 'Respiratory Distress Syndrome', 'Respiratory Insufficiency', 'Respiratory Muscles'] | 2,060,340 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.495'], ['M01.060.116.630'], ['A01.456.505.631', 'A03.556.500', 'A14.549'], ['C10.114.750', 'C10.314.750', 'C10.668.829.800.750', 'C20.111.258.750'], ['G01.374.715'], ['E01.370.386.700.... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Endoscopic sphincterotomy, artificial AMS 800 sphincter and enlargement enterocystoplasty in the treatment of a dyssynergic neurological bladder]. | Endoscopic sphincterotomy, AMS 800 artificial urinary sphincter and enlargement cystoplasty for treating a neurologic dyssynergic bladder. Association of endoscopic sphincterotomy made on a first operating time, with AMS 800 artificial sphincter and enlargement cystoplasty is a good choice for treating selected patient... | ['Adult', 'Humans', 'Ilium', 'Magnetic Resonance Imaging', 'Male', 'Prostheses and Implants', 'Spina Bifida Occulta', 'Urinary Bladder', 'Urinary Bladder Calculi', 'Urinary Bladder, Neurogenic'] | 2,093,292 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.043.825.434'], ['E01.370.350.825.500'], ['E07.695'], ['C10.500.680.800.750', 'C16.131.666.680.800.750'], ['A05.810.890'], ['C12.777.829.720', 'C12.777.967.500.925', 'C13.351.968.829.521', 'C13.351.968.967.500.925', 'C23.300.175.850.875'], ... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Internal medicine consultation]. | The Internal Medicine consultation plays an important part in the activity of the Medicine Department. This activity is seldom quantified and is usually underestimated. In order to assess the work load represented by this service, the authors designed a prospective study to quantify and analyse the characteristics of t... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Female', 'Hospital Departments', 'Humans', 'Internal Medicine', 'Male', 'Middle Aged', 'Prospective Studies', 'Referral and Consultation'] | 15,941,550 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['N02.278.216.500.968', 'N04.452.442.452.422'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.429'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Transient expression assay for qualitative assessment of gene expression by fowlpox virus. | A transient expression assay for fowlpox virus (FPV) was developed to assess the feasibility of using heterologous promoters in FPV and to qualitatively determine relative promoter strength. A transient expression system for FPV has not been reported, and various methods used for transient expression in vaccinia-virus-... | ['Animals', 'Cells, Cultured', 'Chick Embryo', 'Evaluation Studies as Topic', 'Fibroblasts', 'Fowlpox virus', 'Gene Expression', 'Genomic Library', 'Lac Operon', 'Plasmids', 'Promoter Regions, Genetic', 'Transfection'] | 2,161,157 | [['B01.050'], ['A11.251'], ['A13.350.150', 'A16.331.200'], ['E05.337', 'N05.715.360.335'], ['A11.329.228'], ['B04.280.650.160.100.300'], ['G05.297'], ['G05.360.325.425', 'G05.360.340.425'], ['G05.360.340.024.686.545', 'G05.360.340.358.207.500.545'], ['G05.360.600'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Baculovirus-mediated expression of truncated modular fragments from the catalytic region of human complement serine protease C1s. Evidence for the involvement of both complement control protein modules in the recognition of the C4 protein substrate. | C1s is the modular serine protease responsible for cleavage of C4 and C2, the protein substrates of the first component of complement. Its catalytic region (gamma-B) comprises two complement control protein (CCP) modules, a short activation peptide (ap), and a serine protease domain (SP). A baculovirus-mediated express... | ['Animals', 'Baculoviridae', 'Catalysis', 'Chromatography, Liquid', 'Cloning, Molecular', 'Complement C1s', 'Complement C4', 'Electrophoresis, Polyacrylamide Gel', 'Humans', 'Peptide Fragments', 'Recombinant Proteins', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'Spodoptera', 'Substrate Specifici... | 9,422,791 | [['B01.050'], ['B04.280.065', 'B04.525.100'], ['G02.130'], ['E05.196.181.400'], ['E05.393.220'], ['D08.811.277.300.290', 'D12.776.124.486.274.045.290', 'D12.776.124.486.274.050.290'], ['D12.776.124.486.274.350'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.541'], [... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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