Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Properties of myelin altered peptide ligand cyclo(87-99)(Ala91,Ala96)MBP87-99 render it a promising drug lead for immunotherapy of multiple sclerosis. | Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system, and it has been established that autoreactive T helper (Th) cells play a crucial role in its pathogenesis. Myelin basic protein (MBP) epitopes are major autoantigens in MS, and the sequence MBP87-99 is an immunodominant epi... | ['Adolescent', 'Adult', 'Aged', 'Animals', 'Cell Proliferation', 'Encephalomyelitis, Autoimmune, Experimental', 'Female', 'Humans', 'Immunotherapy', 'Leukocytes, Mononuclear', 'Ligands', 'Male', 'Middle Aged', 'Molecular Structure', 'Multiple Sclerosis', 'Myelin Basic Protein', 'Peptide Fragments', 'Rats', 'Rats, Inbre... | 26,112,377 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050'], ['G04.161.750', 'G07.345.249.410.750'], ['C10.114.703.300', 'C10.228.140.695.562.250', 'C10.314.350.250', 'C20.111.258.625.300', 'E05.598.500.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425'], ['A11.118.637.555', 'A15.145... | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Efficacy of mouth rinse in preventing oral mucositis in patients receiving high-dose cytarabine for allogeneic hematopoietic stem cell transplantation. | High-dose cytarabine is one of the major components of the conditioning regimen for hematopoietic stem cell transplantation (HSCT), and frequently causes severe oral mucositis. We have recently demonstrated that cytarabine is excreted into the saliva in patients receiving high-dose cytarabine, and proposed that it migh... | ['Adult', 'Cytarabine', 'Female', 'Hematologic Neoplasms', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Immunosuppressive Agents', 'Incidence', 'Male', 'Middle Aged', 'Oral Hygiene', 'Stomatitis', 'Transplantation Conditioning', 'Transplantation, Homologous', 'Whole-Body Irradiation'] | 18,972,188 | [['M01.060.116'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['C04.588.448', 'C15.378.400'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Efficacy and safety of postoperative early mobilization for chronic subdural hematoma in elderly patients. | BACKGROUND: The incidences of chronic subdural hematoma (CSDH) will probably increase with the aging of the population; thus, postoperative care of elderly CSDH patients may play a more important role in surgical management. The aim of this study was to evaluate the efficacy of and adverse effects after postoperative e... | ['Aged', 'Aged, 80 and over', 'Craniotomy', 'Early Ambulation', 'Female', 'Hematoma, Subdural, Chronic', 'Humans', 'Male', 'Postoperative Care', 'Postoperative Complications', 'Prospective Studies'] | 20,336,332 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.525.190'], ['E02.760.169.063.500.335', 'E02.831.335'], ['C10.228.140.300.535.450.400.120', 'C10.900.300.837.600.120', 'C14.907.253.573.400.450.120', 'C23.550.414.838.700.200', 'C23.550.414.913.700.200', 'C26.915.300.490.450.120'], ['B01.050.150.900.649.313.988.400.11... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Attitudes to cuts in expenditure and increased fees in health care. | The aim of this postal questionnaire study was to measure attitudes to cuts and increased fees in health care in various Finnish population groups. Four groups were identified; a population sample of 2000 subjects, aged 18-70 y; a random sample of 1500 medical doctors of working age; a random sample of 1000 nurses of w... | ['Adolescent', 'Adult', 'Aged', 'Attitude to Health', 'Fees, Medical', 'Female', 'Financing, Personal', 'Finland', 'Health Care Rationing', 'Health Expenditures', 'Health Priorities', 'Humans', 'Male', 'Middle Aged', 'Primary Health Care', 'Social Values', 'Surveys and Questionnaires'] | 9,090,279 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F01.100.150', 'N05.300.150'], ['N03.219.300.426', 'N03.219.442.426'], ['N03.219.559'], ['Z01.542.816.186'], ['I01.261.750.500', 'N03.349.270', 'N05.300.430.375'], ['N03.219.151.450', 'N05.300.385'], ['N03.349.330', 'N05.300.400'], ['B01.050.150.900.649.313.988.4... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Dropped gallstones post laparoscopic cholecystectomy mimicking peritoneal seeding: CT and ultrasound features. | PURPOSE: The purpose of this work was to investigate the ultrasound (US) and CT features of dropped gallstones mimicking peritoneal seeding in patients after laparoscopic cholecystectomy (LCC).METHOD: We describe the US and CT features of dropped gallstones mimicking peritoneal seeding in eight patients who underwent L... | ['Adult', 'Aged', 'Cholecystectomy, Laparoscopic', 'Cholelithiasis', 'Diagnosis, Differential', 'Female', 'Functional Laterality', 'Humans', 'Male', 'Medical Errors', 'Middle Aged', 'Peritoneal Diseases', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 12,488,750 | [['M01.060.116'], ['M01.060.116.100'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['C06.130.409'], ['E01.171'], ['F02.830.297.425', 'G11.561.225.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.450'], ['M01.060.116.630'], ['C06.844'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Developmental validation of the PowerPlex® ESX 16 and PowerPlex® ESX 17 Systems. | We describe the developmental validation study performed on the PowerPlex(®) ESX 16 (European Standard Extended 16) and the PowerPlex(®) ESX 17 Systems, part of a suite of four new DNA profiling kits developed by Promega in response to the ENFSI and EDNAP groups' call for new STR multiplexes for Europe. The PowerPlex(®... | ['DNA', 'Gene Frequency', 'Humans', 'Microsatellite Repeats', 'Polymerase Chain Reaction'] | 21,466,982 | [['D13.444.308'], ['G05.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['E05.393.620.500']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The regularities and tendencies of infant and children mortality in the Russian Federation]. | The article presents dynamics and causes of infant and children mortality in the Russian Federation during post-soviet period (1990-2012) in conditions of implementation of demographic policy and reforming of health care system. The data of official statistics of Rosstat (1990-2012) is analyzed. The comparative analysi... | ['Cause of Death', 'Child', 'Child Mortality', 'Humans', 'Infant', 'Infant Mortality', 'Russia'] | 26,012,278 | [['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['M01.060.406'], ['E05.318.308.985.550.287', 'N01.224.935.698.150', 'N06.850.505.400.975.550.287', 'N06.850.520.308.985.550.287'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.31... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Structural requirements of mono- and multivalent L-selectin blocking aptamers for enhanced receptor inhibition in vitro and in vivo. | UNLABELLED: L-selectin mediates extravasation of leukocytes from blood into the surrounding tissue during inflammation and is therefore a therapeutical target in certain overwhelming immune reactions. In this study, we characterized an L-selectin specific blocking DNA aptamer with respect to nucleotide composition and ... | ['Aptamers, Nucleotide', 'Blood Buffy Coat', 'Cell Adhesion', 'Healthy Volunteers', 'Humans', 'Inflammation', 'L-Selectin', 'Leukocytes', 'Ligands', 'Oligonucleotides', 'Protein Binding'] | 26,772,426 | [['D13.695.578.424.224'], ['A15.145.229.093'], ['G04.022'], ['M01.774.500', 'M01.955.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['D12.776.395.550.200.625.903', 'D12.776.395.550.200.700.510', 'D12.776.503.843.510', 'D12.776.543.550.200.625.903', 'D12.776.543.550.200.700.510', 'D12.776.543.7... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Radioactive mercury distribution in biological fluids and excretion in human subjects after inhalation of mercury vapor. | The distribution of mercury in red blood cells (RBCs) and plasma, and its excretion in urine and feces are described in five human subjects during the first 7 days following inhalation of radioactive mercury vapor. A major portion (98%) of radioactive mercury in whole blood is initially accumulated in the RBCs and is t... | ['Adult', 'Erythrocytes', 'Feces', 'Gases', 'Humans', 'Male', 'Mercury', 'Mercury Radioisotopes', 'Respiration', 'Time Factors', 'Tissue Distribution'] | 686,833 | [['M01.060.116'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['A12.459'], ['D01.362'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['D01.268.556.504.500.500', 'D01.268.956.437.500.500', 'D01.496.532.500', 'D01.496.749.590', 'D01.552.544.504.500.500... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cord atrophy separates early primary progressive and relapsing remitting multiple sclerosis. | BACKGROUND AND OBJECTIVE: The onset of multiple sclerosis is relapsing remitting or primary progressive. An improved understanding of the causes of early progressive disability in primary progressive multiple sclerosis (PPMS) could provide mechanistic targets for therapeutic intervention.METHODS: Five magnetic resonanc... | ['Adult', 'Aged', 'Atrophy', 'Case-Control Studies', 'Disease Progression', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Multiple Sclerosis, Chronic Progressive', 'Multiple Sclerosis, Relapsing-Remitting', 'Recurrence', 'Spinal Cord'] | 16,793,860 | [['M01.060.116'], ['M01.060.116.100'], ['C23.300.070'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C10.114.375.500.200', 'C10.314.350.500.200', 'C20.111.258.250.500.2... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Autonomic regulation therapy for the improvement of left ventricular function and heart failure symptoms: the ANTHEM-HF study. | BACKGROUND: Outcomes of heart failure (HF) have improved dramatically with the use of blockers of the sympathetic and renin-angiotensin-aldosterone systems, as well as with more prevalent use of implantable cardiac defibrillators and cardiac resynchronization therapy. Despite these interventions, however, the overall p... | ['Autonomic Nervous System', 'Cardiac Resynchronization Therapy', 'Defibrillators, Implantable', 'Feasibility Studies', 'Heart Failure', 'Humans', 'Treatment Outcome', 'Vagus Nerve Stimulation', 'Ventricular Dysfunction, Left'] | 24,054,343 | [['A08.800.050'], ['E02.331.200.500'], ['E07.305.250.159.175', 'E07.305.250.319.175', 'E07.695.202.175'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'],... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The Supragingival Biofilm in Early Childhood Caries: Clinical and Laboratory Protocols and Bioinformatics Pipelines Supporting Metagenomics, Metatranscriptomics, and Metabolomics Studies of the Oral Microbiome. | Early childhood caries (ECC) is a biofilm-mediated disease. Social, environmental, and behavioral determinants as well as innate susceptibility are major influences on its incidence; however, from a pathogenetic standpoint, the disease is defined and driven by oral dysbiosis. In other words, the disease occurs when the... | ['Bacteria', 'Biofilms', 'Child, Preschool', 'DNA, Bacterial', 'Dental Caries', 'Gene Expression Profiling', 'Gingiva', 'Humans', 'Metabolomics', 'Metagenomics', 'Microbiota', 'RNA, Bacterial', 'Sequence Analysis, DNA', 'Sequence Analysis, RNA', 'Software', 'Specimen Handling', 'Tooth, Deciduous', 'Transcriptome'] | 30,838,598 | [['B03'], ['A20.593', 'G06.120'], ['M01.060.406.448'], ['D13.444.308.212'], ['C07.793.720.210'], ['E05.393.332'], ['A14.549.167.646.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.201.586', 'H01.158.273.180.599', 'H01.181.122.638'], ['H01.158.273.343.350.261'], ['G06.591', 'G16.500.275.157.049.100.500... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Piscine orthoreovirus subtype 3 (PRV-3) causes heart inflammation in rainbow trout (Oncorhynchus mykiss). | Piscine orthoreovirus (PRV) mediated diseases have emerged throughout salmonid aquaculture. Three PRV subtypes are currently reported as causative agents of or in association with diseases in different salmonid species. PRV-1 causes heart and skeletal muscle inflammation (HSMI) in Atlantic salmon (Salmo salar) and is a... | ['Animals', 'Fish Diseases', 'Heart Diseases', 'Immunity, Innate', 'Inflammation', 'Oncorhynchus mykiss', 'Orthoreovirus', 'Reoviridae Infections'] | 30,777,130 | [['B01.050'], ['C22.362'], ['C14.280'], ['G12.450.564'], ['C23.550.470'], ['B01.050.150.900.493.817.750.825.580.600'], ['B04.820.223.719.590'], ['C01.925.782.791']] | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses. | The RNA interference (RNAi)-based therapeutic ARC-520 for chronic hepatitis B virus (HBV) infection consists of a melittin-derived peptide conjugated to N-acetylgalactosamine for hepatocyte targeting and endosomal escape, and cholesterol-conjugated RNAi triggers, which together result in HBV gene silencing. To characte... | ['Animals', 'Argonaute Proteins', 'Female', 'Gene Knockdown Techniques', 'Hepatitis B Surface Antigens', 'Hepatitis B virus', 'Hepatitis B, Chronic', 'Humans', 'Kinetics', 'Liver', 'Mice', 'Mice, Inbred ICR', 'Mice, Inbred NOD', 'Mice, SCID', 'Mice, Transgenic', 'Peptide Nucleic Acids', 'Phosphorylation', 'RNA Interfer... | 28,180,327 | [['B01.050'], ['D08.811.277.352.355.350.810.500', 'D08.811.277.352.700.350.810.500', 'D12.776.157.725.500.906.500', 'D12.776.664.962.500.906.500'], ['E05.393.335.500'], ['D23.050.327.495.500.475'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925.440.435.100', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Balloon embolectomy catheters in small arteries. III. Surgical significance of eccentric balloons. | Some embolectomy balloons distend eccentrically. This study was undertaken to compare balloon eccentricity in air with that which occurs in arteries, to determine the influence of balloon eccentricity on shear force, and to estimate the injury potential of eccentric balloons. We studied 21 Edwards and 17 Shiley cathete... | ['Animals', 'Carotid Arteries', 'Carotid Artery Injuries', 'Dogs', 'Embolism', 'Methods', 'Models, Biological', 'Postoperative Complications'] | 6,829,008 | [['B01.050'], ['A07.015.114.186'], ['C10.228.140.300.200.345', 'C10.228.140.300.350.500', 'C10.900.250.300', 'C14.907.253.123.345', 'C14.907.253.535.500', 'C26.915.200.200'], ['B01.050.150.900.649.313.750.250.216.200'], ['C14.907.355.350'], ['E05.581'], ['E05.599.395'], ['C23.550.767']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sociodemographic risk factors and correlates of dementia in older Malaysians. | OBJECTIVE: The rapid expansion of the aged population in Malaysia is expected to greatly increase the number of persons with dementia in the country. However, data on dementia prevalence at the national level is lacking, and little is known about the sociodemographic risk factors and correlates of dementia. This paper ... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Asian Continental Ancestry Group', 'Dementia', 'Education', 'Employment', 'Ethnic Groups', 'Female', 'Geriatric Assessment', 'Humans', 'Malaysia', 'Male', 'Marital Status', 'Middle Aged', 'Neuropsychological Tests', 'Quality of Life', 'Risk Factors', 'Rural Population', 'Se... | 21,252,548 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.686.508.200'], ['C10.228.140.380', 'F03.615.400'], ['I02'], ['N01.824.245'], ['M01.686.754', 'N01.224.317'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.5... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Convulsions from excessive dosage of nalidixic acid: a case report. | A 4-year-old girl who developed convulsions after an accidental ingestion of excessive dosage (50 mg/kg) of nalidixic acid, while treated with the drug (50 mg/kg/day) over 30 days for a urinary tract infection, was reported. Thirty minutes after ingestion, vomiting, tonic-clonic seizures, and abnormal movements were su... | ['Child, Preschool', 'Dose-Response Relationship, Drug', 'Female', 'Humans', 'Nalidixic Acid', 'Seizures', 'Urinary Tract Infections'] | 553,453 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Postnatal expression of myostatin propeptide cDNA maintained high muscle growth and normal adipose tissue mass in transgenic mice fed a high-fat diet. | Myostatin plays a robust, negative role in controlling muscle mass. A disruption of myostatin function by transgenic expression of its propeptide (the 5'region, 866 nucleotides) results in significant muscle growth (Yang et al., 2001. Mol Rep Dev 60:351-361). Studies from myostatin and the propeptide transgene mRNA ind... | ['Adipose Tissue', 'Animals', 'Animals, Newborn', 'Body Weight', 'DNA, Complementary', 'Dietary Fats', 'Female', 'Gene Expression Regulation, Developmental', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Muscle, Skeletal', 'Myostatin', 'Peptides', 'Protein Precursors', 'RNA, Messenger', 'Transforming Growth Factor... | 16,437,538 | [['A10.165.114'], ['B01.050'], ['B01.050.050.282'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['G05.308.310'], ['B0... | ['Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Functional diversification of grapevine MYB5a and MYB5b in the control of flavonoid biosynthesis in a petunia anthocyanin regulatory mutant. | Flavonoids play a key role in grapevine physiology and also contribute substantially to the quality of berries and wines. VvMYB5a and VvMYB5b are R2R3-MYB transcription factors previously proposed to control the spatiotemporal expression of flavonoid structural genes during berry development. We investigated the functi... | ['Anthocyanins', 'Flavonoids', 'Gene Expression Regulation, Plant', 'Petunia', 'Transcription Factors', 'Vitis'] | 24,363,289 | [['D03.383.663.283.266.450.087', 'D03.633.100.150.266.450.087', 'D09.408.084', 'D23.767.124'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['G05.308.375'], ['B01.650.940.800.575.912.250.908.500.448'], ['D12.776.930'], ['B01.650.940.800.575.912.250.965.500']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Documenting Patient Care in EHRs. | New Texas Medical Board rules attempt to underscore the importance of accurate information in the data-saturated electronic health record system and make doctors' reporting requirements clearer. | ['Documentation', 'Electronic Health Records', 'Humans', 'Medical Records Systems, Computerized', 'Patient Care Planning', 'Texas', 'United States'] | 26,201,069 | [['L01.453.245'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.940.968.625', 'L01.313.500.750.300.695', 'N04.452.859.564.650', 'N05.715.360.300.715.500.530', 'N06.850.520.3... | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Validation of different instruments for caffeine measurement among premenopausal women in the BioCycle study. | Effects of caffeine on women's health are inconclusive, in part because of inadequate exposure assessment. In this study we determined 1) validity of a food frequency questionnaire compared with multiple 24-hour dietary recalls (24HDRs) for measuring monthly caffeine and caffeinated beverage intakes; and 2) validity of... | ['Adolescent', 'Adult', 'Beverages', 'Caffeine', 'Coffee', 'Diet', 'Diet Records', 'Female', 'Humans', 'Mental Recall', 'Premenopause', 'Validation Studies as Topic', "Women's Health", 'Young Adult'] | 23,462,965 | [['M01.060.057'], ['M01.060.116'], ['G07.203.100', 'J02.200'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D20.215.784.249', 'G07.203.100.325', 'J02.200.325'], ['G07.203.650.240'], ['N04.452.859.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.641'], ['G08.686.157.500.812', 'G08.686.8... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Saccade-related activity in the lateral intraparietal area. II. Spatial properties. | 1. Single-neuron activity was recorded from the inferior parietal lobule (IPL) of Macaca mulatta monkeys while they were performing delayed saccades and related tasks. Temporal characteristics of this activity were presented in the companion paper. Here we focus on the spatial characteristics of the activity. The analy... | ['Animals', 'Cerebral Cortex', 'Conditioning, Operant', 'Macaca mulatta', 'Male', 'Motion Perception', 'Neurons', 'Parietal Lobe', 'Photic Stimulation', 'Saccades', 'Visual Fields'] | 1,753,277 | [['B01.050'], ['A08.186.211.200.885.287.500'], ['F02.463.425.179.509'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['F02.463.593.932.567'], ['A08.675', 'A11.671'], ['A08.186.211.200.885.287.500.670'], ['E05.723.729'], ['G14.350.500'], ['F02.463.593.932.934', 'G14.950']] | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Associations of epithelial sodium channel genes with blood pressure changes and hypertension incidence: the GenSalt study. | BACKGROUND: We examined the associations of epithelial sodium channel (ENaC) genes with blood pressure (BP) changes and hypertension incidence in a longitudinal family study.METHODS: A total of 2,755 Han Chinese participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) baseline examination were eli... | ['Adult', 'Aged', 'Asian Continental Ancestry Group', 'Blood Pressure', 'China', 'Epithelial Sodium Channels', 'Female', 'Genetic Predisposition to Disease', 'Humans', 'Hypertension', 'Incidence', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Phenotype', 'Polymorphism, Single Nucleotide', 'Risk Factors', 'Time Factor... | 24,735,600 | [['M01.060.116'], ['M01.060.116.100'], ['M01.686.508.200'], ['E01.370.600.875.249', 'G09.330.380.076'], ['Z01.252.474.164'], ['D12.776.157.530.400.875.200', 'D12.776.543.550.450.875.200', 'D12.776.543.585.400.875.200'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Nonspecific ulcer of the colon: a report on 12 endoscopically diagnosed cases]. | Report on 12 patients with nonspecific ulcers of the colon diagnosed by colonscopy and biopsy. In 10 patients the course was favorable with conservative management. In 2 patients the symptoms were aggravated; in both patients this was due to a penetrating malignant tumour diagnosed at laparotomy a few weeks later. It i... | ['Aged', 'Biopsy', 'Cecal Diseases', 'Colon, Sigmoid', 'Colonic Diseases', 'Female', 'Humans', 'Male', 'Middle Aged', 'Sigmoidoscopy', 'Ulcer'] | 432,591 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of tetrandrine on spontaneous and evoked release of acetylcholine at the mouse neuromuscular junction. | The action of tetrandrine on spontaneous and phasic acetyl-choline (ACh) release was investigated at the mouse neuromuscular junction recording miniature endplate potentials (MEPPs) and endplate potentials. Superfusion of muscles with tetrandrine (10 microM) in normal Krebs-Ringer solution induced an increase of the me... | ['Acetylcholine', 'Action Potentials', 'Alkaloids', 'Animals', 'Benzylisoquinolines', 'Calcium', 'Emetine', 'Female', 'Ion Channels', 'Isotonic Solutions', 'Mice', 'Motor Endplate', 'Neuromuscular Junction', 'Tetrodotoxin'] | 8,930,197 | [['D02.092.211.111'], ['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['D03.132'], ['B01.050'], ['D03.132.098', 'D03.633.100.531.085'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D03.132.316', 'D03.633.100.531.321'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['D26.776.4... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Electron microscopic observation of synaptonemal complexes in spermatocytes of six species of fishes]. | The synaptonemal complexes (SCs) in spermatocytes of six species of fishes were detected with a combination of surface spreading and silver staining technique and observed under both light and electron microscopes. These fishes are Tilapia nilotica, T. mossambica and Mastacembelus sinensis of Perciformes. Sarcocheilich... | ['Animals', 'Fishes', 'Male', 'Microscopy, Electron', 'Sex Differentiation', 'Spermatocytes', 'Synaptonemal Complex'] | 1,781,999 | [['B01.050'], ['B01.050.150.900.493'], ['E01.370.350.515.402', 'E05.595.402'], ['G07.345.500.325.377.843', 'G07.345.750.500', 'G08.686.841.500'], ['A05.360.490.890.880', 'A11.497.760.700'], ['A11.284.430.106.279.345.190.160.830', 'G04.144.220.220.687.883.250.500', 'G04.144.220.220.781.906.250.500', 'G05.113.220.687.883... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Ultrastructure of blast cells in patients with myeloblastic, monoblastic and myelomonoblastic leukemia]. | Electron microscopy was applied to study and compare blast cells in 7 patients with acute myeloblastic, 4 with acute monoblastic and 11 patients with acute myelomonoblastic leukemias. Three morphological types of blast cells are described for acute myeloblastic leukemia and 2 types of blast cells for acute monoblastic ... | ['Hematopoietic Stem Cells', 'Humans', 'Leukemia, Monocytic, Acute', 'Leukemia, Myeloid, Acute', 'Microscopy, Electron', 'Monocytes'] | 3,860,997 | [['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.275.484'], ['C04.557.337.539.275'], ['E01.370.350.515.402', 'E05.595.402'], ['A11.118.637.555.652', 'A11.148.580', 'A11.627.624', 'A11.733.547', 'A15.145.229.637.555.652', 'A15.378.316.580', 'A15.382.4... | ['Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The discovery and optimization of benzimidazoles as selective NaV | The voltage gated sodium channel NaV1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole NaV1.8 blockers. Subsequent optimization allowed the identification of com... | ['Benzimidazoles', 'Drug Design', 'HEK293 Cells', 'Humans', 'Molecular Structure', 'NAV1.8 Voltage-Gated Sodium Channel', 'Solubility', 'Structure-Activity Relationship', 'Voltage-Gated Sodium Channel Blockers'] | 30,538,065 | [['D03.633.100.103'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570', 'G02.466'], ['D12.776.157.530.400.875.750.800', 'D12.776.543.550.450.875.750.800', 'D12.776.543.585.400.875.750.800', 'D12.776... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Early results of continuous passive motion after rotator cuff repair: a prospective, randomized, blinded, controlled study. | PURPOSE: To determine the effect of continuous passive motion (CPM) on rotator cuff repair (RCR).METHODS: A prospective, randomized, blinded, controlled study was performed on all patients undergoing primary RCR between December 1992 and January 1994. A preoperative "shoulder score" was calculated for each patient base... | ['Activities of Daily Living', 'Female', 'Humans', 'Male', 'Middle Aged', 'Motion Therapy, Continuous Passive', 'Prospective Studies', 'Rotator Cuff', 'Rotator Cuff Injuries', 'Single-Blind Method', 'Tendon Injuries', 'Treatment Outcome'] | 8,775,698 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.760.169.063.500.387.500', 'E02.779.483.500', 'E02.779.867.761', 'E02.831.535.483.500', 'E02.831.535.867.761'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Barriers to electronic cigarette use. | OBJECTIVE: Recent studies suggest that electronic cigarettes (e-cigarettes) may be a better alternative to traditional smoking cessation therapies for cigarette smokers. This study explores the barriers traditional smokers face when switching to e-cigarettes.DESIGN AND SAMPLE: A convenience sample of adult male and fem... | ['Adult', 'Electronic Nicotine Delivery Systems', 'Female', 'Health Behavior', 'Humans', 'Male', 'Nicotine', 'Smoking', 'Smoking Cessation', 'Surveys and Questionnaires', 'Tobacco Products', 'Young Adult'] | 29,984,426 | [['M01.060.116'], ['J01.637.767.500'], ['F01.145.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.132.760.570', 'D03.383.725.518'], ['F01.145.805'], ['F01.145.488.732'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['J01.637.767.844'], ['M01.060.116.815']] | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Timing of colonic necrosis in hemolytic uremic syndrome. | Hemolytic uremic syndrome (HUS) consists of an acute onset of microangiopathic hemolytic anemia, thrombocytopenia, and renal dysfunction. HUS-associated colitis can be seen in up to 100% of patients and is usually associated with severe abdominal pain and distention. Colonic perforation is a complication of HUS that ha... | ['Adolescent', 'Child', 'Child, Preschool', 'Colon', 'Colonic Diseases', 'Female', 'Hemolytic-Uremic Syndrome', 'Humans', 'Infant', 'Intestinal Perforation', 'Male', 'Necrosis', 'Retrospective Studies'] | 9,553,186 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C06.405.469.158'], ['C12.777.419.936.463', 'C13.351.968.419.936.463', 'C15.378.071.141.610', 'C15.378.140.855.925.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C06.405.469.557'], ['C23.... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A study of the efficacy and safety of transurethral needle ablation (TUNA) treatment for benign prostatic hyperplasia. | The objective of this early phase III study was to determine the efficacy and safety of transurethral needle ablation (TUNA) in patients presenting in acute urinary retention due to benign prostatic hyperplasia (BPH). Between September 1993 and August 1994, 20 patients of mean age 68.8 years were entered into a two-cen... | ['Aged', 'Aged, 80 and over', 'Catheter Ablation', 'Cohort Studies', 'Cystoscopy', 'Humans', 'Male', 'Middle Aged', 'Needles', 'Postoperative Complications', 'Prospective Studies', 'Prostate', 'Prostatic Hyperplasia', 'Treatment Outcome', 'Ultrasonography', 'Urethra', 'Urethral Obstruction', 'Urinary Retention'] | 8,916,114 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.808.750.500', 'E04.014.760.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.388.250.180', 'E01.370.390.175', 'E04.502.250.180', 'E04.950.774.155'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Immediate loading of implants placed in fresh extraction sockets in the molar area with flapless and graftless procedures: a case series. | The purpose of this study was to present a protocol for the replacement of single teeth lost in the molar area with immediate implantation in fresh extraction sockets, no flap reflections or grafting procedures, and immediate loading. Twenty-three implants were placed in 20 patients between 2000 and 2006. No implants w... | ['Adult', 'Aged', 'Crowns', 'Dental Implantation, Endosseous', 'Dental Implants, Single-Tooth', 'Dental Prosthesis, Implant-Supported', 'Dental Restoration, Temporary', 'Dental Stress Analysis', 'Female', 'Humans', 'Male', 'Middle Aged', 'Models, Anatomic', 'Molar', 'Time Factors', 'Tooth Extraction', 'Tooth Socket', '... | 20,386,786 | [['M01.060.116'], ['M01.060.116.100'], ['E06.780.346.250', 'E07.695.190.088'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['E06.780.346.593.185', 'E07.695.185.185'], ['E06.780.346.706', 'E07.695.190.185'], ['E06.323.528', 'E06.780.346.740', 'E07.695.190.192'], ['E06.308'], ['B... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
Isolation of transglutaminase-reactive sequences from complex biological systems: a prominent lysine donor sequence in bovine lens. | The transglutaminase (protein-glutamine: amine gamma-glutamyltransferase, EC 2.3.2.13)-catalyzed cross-linking of proteins in biological systems can often be inhibited by inclusion of small primary amines or glutamine-containing peptides, which act as site-specific blockers of the relevant acceptor (i.e., glutamine) an... | ['Amino Acid Sequence', 'Animals', 'Cadaverine', 'Cattle', 'Crystallins', 'Dansyl Compounds', 'Lens, Crystalline', 'Lysine', 'Molecular Sequence Data', 'Molecular Weight', 'Oligopeptides', 'Transglutaminases'] | 1,360,664 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D02.092.211.415.261', 'D02.092.782.258.174'], ['B01.050.150.900.649.313.500.380.271'], ['D12.776.306.366'], ['D02.455.426.559.847.638.204', 'D02.886.590.192', 'D04.615.638.204'], ['A09.371.060.500'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Texture analysis of poly-adenylated mRNA staining following global brain ischemia and reperfusion. | Texture analysis provides a means to quantify complex changes in microscope images. We previously showed that cytoplasmic poly-adenylated mRNAs form mRNA granules in post-ischemic neurons and that these granules correlated with protein synthesis inhibition and hence cell death. Here we utilized the texture analysis sof... | ['Animals', 'Brain Ischemia', 'Cell Death', 'Male', 'Poly A', 'RNA, Messenger', 'Rats', 'Rats, Long-Evans', 'Reperfusion', 'Software', 'Staining and Labeling'] | 21,477,879 | [['B01.050'], ['C10.228.140.300.150', 'C14.907.253.092'], ['G04.146'], ['D13.695.578.550.500'], ['D13.444.735.544'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.500'], ['E04.100.700', 'E05.680.730'], ['L01.224.900'], ['E01.370.225.500.620.670', 'E01.370.225.750.600.670', 'E05.... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Workflow for a Computational Analysis of an sRNA Candidate in Bacteria. | Computational methods can often facilitate the functional characterization of individual sRNAs and furthermore allow high-throughput analysis on large numbers of sRNA candidates. This chapter outlines a potential workflow for computational sRNA analyses and describes in detail methods for homolog detection, target pred... | ['Computational Biology', 'Cyanobacteria', 'Genome, Bacterial', 'Genomics', 'RNA, Bacterial', 'RNA, Small Untranslated', 'Workflow'] | 29,484,584 | [['H01.158.273.180', 'L01.313.124'], ['B03.280', 'B03.440.475.100'], ['G05.360.340.358.207'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['D13.444.735.473'], ['D13.444.735.790.552'], ['L01.906.893']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Increased lipid peroxide levels and myeloperoxidase activity in the vitreous of patients suffering from proliferative diabetic retinopathy. | Lipid peroxide (LPO) levels, as determined by high-performance liquid chromatography (HPLC) and by the thiobarbituric acid (TBA) method, and myeloperoxidase (MPO) activity in vitreous of patients vitrectomized because of proliferative diabetic retinopathy were compared with LPO levels and MPO activity in vitreous of pa... | ['Chromatography, High Pressure Liquid', 'Diabetic Retinopathy', 'Eye Diseases', 'Humans', 'Lipid Peroxides', 'Peroxidase', 'Retinal Diseases', 'Thiobarbituric Acid Reactive Substances', 'Vitreous Body'] | 8,258,399 | [['E05.196.181.400.300'], ['C11.768.257', 'C14.907.320.382', 'C19.246.099.500.382'], ['C11'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.248.497.158.685.750.637', 'D01.339.431.374.637', 'D01.650.550.750.600', 'D02.389.338.450', 'D10.440'], ['D08.811.682.732.700'], ['C11.768'], ['D02.047.700.700', 'D27.720.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Activity of a sperm-borne oocyte-activating factor in spermatozoa and spermatogenic cells from cynomolgus monkeys and its localization after oocyte activation. | It is widely accepted that mature mammalian oocytes are induced to resume meiosis by a sperm-borne oocyte-activating factor(s) (sperm factor, SF) immediately after normal fertilization or intracytoplasmic sperm injection. The SF is most likely a soluble factor that is localized within the cytoplasm of mature spermatozo... | ['Animals', 'Calcium', 'Cell Nucleus', 'Female', 'Macaca fascicularis', 'Male', 'Mice', 'Oocytes', 'Sperm Injections, Intracytoplasmic', 'Spermatids', 'Spermatozoa'] | 11,466,200 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['B01.050.150.900.649.313.992.635.505.500'], ['A05.360.490.690.680', 'A11.497.497.600'], ['E02.875.800.750.700', 'E05.820.800.750.700'], ['A05... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of sexual arousal and sexual partner characteristics in HIV+ MSM's intentions to engage in unprotected sexual intercourse. | OBJECTIVE: This study investigated the effects of sexual arousal and sexual partner characteristics as determinants of HIV+ men who have sex with men's (MSM) intentions to engage in unprotected sex.DESIGN: In a computer-based controlled experiment, 67 HIV+ MSM underwent a sexual arousal manipulation and indicated their... | ['Adult', 'Aged', 'Arousal', 'Canada', 'HIV Infections', 'Homosexuality, Male', 'Humans', 'Male', 'Middle Aged', 'Sexual Behavior', 'Sexual Partners', 'Unsafe Sex'] | 18,643,002 | [['M01.060.116'], ['M01.060.116.100'], ['F02.830.104', 'G11.561.035'], ['Z01.107.567.176'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['F01.145.802.975.500.600', 'G08.686.867.500.600'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
[Antibody dynamics of carnivorous mammals and corvine birds infected with Francisella tularensis]. | The time course of antibody formation in carnivorous mammals and corvine birds infected with a single injection of F. tularensis has been experimentally studied in the agglutination test and the passive hemagglutination test. In carnivorous mammals the allergic transformation of the body has been established by means o... | ['Agglutination Tests', 'Animals', 'Antibodies, Bacterial', 'Birds', 'Carnivora', 'Francisella tularensis', 'Hemagglutination Tests', 'Leukocytes', 'Time Factors', 'Tularemia'] | 6,741,361 | [['E01.370.225.812.735.050', 'E05.200.812.735.050', 'E05.478.594.760.050'], ['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['B01.050.150.900.248'], ['B01.050.150.900.649.313.750'], ['B03.440.400.425.340.590', 'B03.660.250.200.750'], ['E01.370.225.812.735.050.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Autocatalytic activity of the tobacco etch virus NIa proteinase in viral and foreign protein sequences. | The small nuclear inclusion (NIa) protein of the tobacco etch virus (TEV) is synthesized initially as part of a genome-derived high M(r) precursor. The NIa protein releases itself from this genome-derived precursor by self-cleavage, or an autocatalytic processing event. Cleavage between specific glutamine-glycine dipep... | ['Amino Acid Sequence', 'Catalysis', 'Endopeptidases', 'Molecular Sequence Data', 'Mutagenesis, Insertional', 'Plant Viruses', 'Plants, Toxic', 'Proteins', 'Recombinant Fusion Proteins', 'Tobacco', 'Viral Proteins'] | 1,634,873 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.130'], ['D08.811.277.656.300'], ['L01.453.245.667'], ['E05.393.420.601.550', 'G05.365.590.575', 'G05.558.550'], ['B04.715'], ['B01.650.660'], ['D12.776'], ['D12.776.828.300'], ['B01.650.940.800.575.912.250.908.500.900'], ['D12.776.964']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
SGRL can regulate chlorophyll metabolism and contributes to normal plant growth and development in Pisum sativum L. | Among a set of genes in pea (Pisum sativum L.) that were induced under drought-stress growth conditions, one encoded a protein with significant similarity to a regulator of chlorophyll catabolism, SGR. This gene, SGRL, is distinct from SGR in genomic location, encoded carboxy-terminal motif, and expression through plan... | ['Amino Acid Sequence', 'Chlorophyll', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Plant', 'Genes, Plant', 'Molecular Sequence Data', 'Mutation', 'Peas', 'Photosynthesis', 'Phylogeny', 'Plant Leaves', 'Plant Proteins', 'Plants, Genetically Modified', 'Protein Structure, Tertiary', 'Sequenc... | 26,346,777 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['G05.308.310'], ['G05.308.375'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['L01.453.245.667'], ['G05.365.590'], ['B01.650.940.800.575.912.250.401.630'], ['G02.111.158.937', 'G02.111.669.700', ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Docking studies of flavonoid compounds as inhibitors of â-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli. | Escherichia coli is one of the most frequent causes of many common bacterial infections, including cholecystitis, bacteremia, cholangitis, urinary tract infection (UTI), traveler's diarrhea and other clinical infections such as neonatal meningitis and pneumonia. The fatty acid biosynthesis is essential for the bacteria... | ['3-Oxoacyl-(Acyl-Carrier-Protein) Synthase', 'Amino Acid Motifs', 'Anti-Bacterial Agents', 'Cerulenin', 'Enzyme Inhibitors', 'Escherichia coli', 'Escherichia coli Proteins', 'Genistein', 'High-Throughput Screening Assays', 'Isoenzymes', 'Molecular Docking Simulation', 'Molecular Sequence Data', 'Protein Binding', 'Pro... | 26,292,066 | [['D08.811.913.050.622'], ['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['D27.505.954.122.085'], ['D02.065.327'], ['D27.505.519.389'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['D03.383.663.283.266.450.400.375', 'D03.633.100.150.266.450.400.375'], ['E05.916.680'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Short-Lived Radical Intermediates in the Photochemistry of Glucose Oxidase. | Glucose oxidase is a flavoprotein that is relatively well-studied as a physico-chemical model system. The flavin cofactor is surrounded by several aromatic acid residues that can act as direct and indirect electron donors to photoexcited flavin. Yet, the identity of the photochemical product states is not well establis... | ['Aspergillus niger', 'Flavin-Adenine Dinucleotide', 'Free Radicals', 'Fungal Proteins', 'Glucose Oxidase', 'Kinetics', 'Light', 'Photochemistry', 'Spectrometry, Fluorescence', 'Tyrosine'] | 31,081,986 | [['B01.300.381.081.450'], ['D03.633.100.733.315.650.249', 'D03.633.100.759.646.138.506', 'D03.633.300.507.650.249', 'D08.211.474.650.249', 'D13.695.667.138.506', 'D13.695.827.068.506', 'D23.767.405.650.249'], ['D01.339', 'D02.389'], ['D12.776.354'], ['D08.811.682.047.239'], ['G01.374.661', 'G02.111.490'], ['G01.358.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Basic investigation for classification of anticancer drugs by pharmacological effects]. | The most effective drugs based on the type of cancer are chosen for chemotherapy. Tumor cells can be targeted at the DNA, RNA or protein level, and most of the classical anticancer drugs interact with tumor DNA in a time-dependent manner or a concentration-dependent manner. However, it has been unclear to date whether ... | ['Antineoplastic Agents', 'Carboplatin', 'Cell Survival', 'Cisplatin', 'DNA, Neoplasm', 'Deoxycytidine', 'Dose-Response Relationship, Drug', 'Drug Screening Assays, Antitumor', 'Humans', 'Lung Neoplasms', 'MCF-7 Cells', 'Paclitaxel', 'Time Factors', 'Tumor Cells, Cultured'] | 22,687,737 | [['D27.505.954.248'], ['D02.257.125'], ['G04.346'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D13.444.308.425'], ['D03.383.742.680.245.500', 'D13.570.230.329', 'D13.570.685.245.500'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['B01.050.1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative genomic hybridization reveals extensive variation among different MCF-7 cell stocks. | Comparative genomic hybridization (CGH) allows the detection of DNA sequence copy number changes on a genome-wide scale in a single hybridization reaction. The ability of CGH to be applied to formalin-fixed, paraffin-embedded tumor samples has lead to its widespread application in the cytogenetic analysis of archival m... | ['Breast Neoplasms', 'Cell Division', 'Chromosome Aberrations', 'Estradiol', 'Humans', 'Nucleic Acid Hybridization', 'Tumor Cells, Cultured'] | 10,704,689 | [['C04.588.180', 'C17.800.090.500'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['C23.550.210', 'G05.365.590.175'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.661', 'G02.111.611'], ['A11.251.860']] | ['Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A sublethal dose of the neonicotinoid insecticide acetamiprid reduces sperm density in a songbird. | Farmland bird species are particularly exposed to pesticides through various pathways. Among pesticides, neonicotinoids insecticides are commonly used in agriculture, but their influence on bird reproductive capacities is poorly understood. In this study, we experimentally tested the effects of the neonicotinoid acetam... | ['Animals', 'Dose-Response Relationship, Drug', 'Humans', 'Insecticides', 'Male', 'Neonicotinoids', 'Songbirds', 'Sperm Count', 'Spermatozoa'] | 31,330,492 | [['B01.050'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.031.700.491', 'D27.888.723.491'], ['D03.383.464'], ['B01.050.150.900.248.620.750'], ['E01.370.225.500.195.870', 'E01.370.225.992.624', 'E05.200.500.195.870', 'E05.200.992.624', 'E05.242.195.870', 'G04.140.87... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Country- and age-specific optimal allocation of dengue vaccines. | Several dengue vaccines are under development, and some are expected to become available imminently. Concomitant with the anticipated release of these vaccines, vaccine allocation strategies for dengue-endemic countries in Southeast Asia and Latin America are currently under development. We developed a model of dengue ... | ['Adult', 'Aging', 'Asia, Southeastern', 'Dengue', 'Dengue Vaccines', 'Geography', 'Humans', 'Latin America', 'Mass Vaccination'] | 24,161,462 | [['M01.060.116'], ['G07.345.124'], ['Z01.252.145'], ['C01.920.500.270', 'C01.925.081.270', 'C01.925.782.350.250.214', 'C01.925.782.417.214'], ['D20.215.894.899.162'], ['H01.277.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.424'], ['E02.095.465.425.400.530.890.500', 'E05.478.550.600.890.500', 'N02.42... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Prosecuting assaultive psychiatric patients. | For many reasons, inpatient psychiatric units are increasingly faced with treatment and management of violent individuals. This fosters a need to consider potential institutional responses to patient violence. This paper focuses on one response--prosecution of these persons. The existing literature on this topic is rev... | ['Adult', 'Hospitals, Psychiatric', 'Humans', 'Inpatients', 'Jurisprudence', 'Male', 'Mental Disorders', 'Violence'] | 1,629,687 | [['M01.060.116'], ['N02.278.421.556.508'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['I01.880.604.583', 'N03.706.535'], ['F03'], ['I01.198.240.856', 'I01.880.735.900']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Reactive gingival lesions: a retrospective study of 2,439 cases. | OBJECTIVE: To identify the clinicopathologic features of epulides in West China and to compare these data with those of previous studies from other countries.METHOD AND MATERIALS: Demographics; clinical data including gender, age, and chief complaints of the patients; and the type, size and location, duration, diagnosi... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Bone Neoplasms', 'Chi-Square Distribution', 'Child', 'Child, Preschool', 'China', 'Female', 'Fibroma, Ossifying', 'Gingival Diseases', 'Granuloma, Giant Cell', 'Granuloma, Pyogenic', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Sex ... | 17,263,149 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.149', 'C05.116.231'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.252.474.164'],... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
British experience with duodenoscopic sphincterotomy for removal of bile duct stones. | Duodenoscopic sphincterotomy is rapidly becoming popular in Britain. Representatives of 14 British centres met in January 1980 to discuss progress and problems with the technique. This report summarizes current experience, with particular reference to hazards. Duodenoscopic sphincterotomy is mainly being used in patien... | ['Aged', 'Ampulla of Vater', 'Cholecystectomy', 'Duodenoscopy', 'Gallstones', 'Humans', 'Methods', 'Middle Aged', 'Postoperative Complications', 'Risk', 'Time Factors', 'United Kingdom'] | 7,237,062 | [['M01.060.116.100'], ['A03.159.183.079.300.950', 'A03.556.124.684.124.236', 'A03.556.875.249.160', 'A03.734.667.500'], ['E04.210.120.172'], ['E01.370.372.250.250.225', 'E01.370.388.250.250.250.200', 'E04.210.240.250.200', 'E04.502.250.250.250.200'], ['C06.130.409.633', 'C06.130.564.332.500', 'C23.300.175.525'], ['B01.... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Glutamine attenuates lipopolysaccharide-induced acute lung injury. | OBJECTIVES: It has been reported that glutamine (GLN) can attenuate acute lung injury after sepsis. GLN is also thought to be a precursor of glutathione (GSH) synthesis. Using the GSH synthesis blocker, L-buthionine-(S,R)-sulfoximine (BSO), we investigated the role of GSH synthesis in the protective effect of GLN on ac... | ['Acute Lung Injury', 'Animals', 'Bronchoalveolar Lavage', 'Bronchoalveolar Lavage Fluid', 'Buthionine Sulfoximine', 'CD11b Antigen', 'CD18 Antigens', 'Disease Models, Animal', 'Glutamine', 'Glutathione', 'Inflammation', 'Interleukin-8', 'Lipopolysaccharides', 'Lung', 'Male', 'Neutrophils', 'Peroxidase', 'Random Alloca... | 19,286,350 | [['C08.381.520.500'], ['B01.050'], ['E05.927.100'], ['E05.927.100.500'], ['D02.886.030.676.620.125', 'D12.125.166.676.620.125'], ['D12.776.395.550.200.074.750', 'D12.776.543.550.200.093.750', 'D12.776.543.750.705.408.100.150', 'D12.776.543.750.705.833.062', 'D23.050.301.350.074.049'], ['D12.776.395.550.200.275.750', 'D... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Injury rates in professional soccer players during Ramadan. | Many of the socio-cultural lifestyle and dietary changes that take place during Ramadan may affect the risk of injury in athletes, but little evidence is available. The aim of the present study was to examine the effects over two consecutive years of the holy month of Ramadan on injury rates in 42 professional players ... | ['Adaptation, Physiological', 'Adult', 'Athletic Injuries', 'Cumulative Trauma Disorders', 'Energy Intake', 'Exercise', 'Fasting', 'Fatigue', 'Humans', 'Islam', 'Musculoskeletal Pain', 'Physical Education and Training', 'Prevalence', 'Retrospective Studies', 'Sleep', 'Soccer', 'Stress, Physiological', 'Tunisia', 'Young... | 22,697,802 | [['G07.025', 'G16.012.500'], ['M01.060.116'], ['C26.115'], ['C26.844.150'], ['G07.203.650.240.340'], ['G11.427.410.698.277', 'I03.350'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.844.275'], ['C05.651.538', 'C23.888.592.612.... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Inherited sensorineural low-frequency hearing impairment: some aspects of phenotype and epidemiology. | This contribution forms part of the HEAR project. It describes some phenotypes of inherited low-frequency sensorineural hearing impairment (LFSHI) and estimates the prevalence of this inherited hearing impairment (HI) based on a clinical series. During a 10-year period (1987-1996), 418 subjects (134 males and 284 femal... | ['Acoustic Impedance Tests', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Audiometry, Pure-Tone', 'Auditory Threshold', 'Bone Conduction', 'Child', 'Child, Preschool', 'Female', 'Hearing Loss, Sensorineural', 'Humans', 'Male', 'Middle Aged', 'Reflex', 'Stapedius'] | 10,749,071 | [['E01.370.382.375.050'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.382.375.060.055'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['F02.830.816.263.500', 'G07.888.500.500', 'G11.561.790.263.398'], ['M01.060.406'], ['M01.060.406.448'], ['C09.218.458... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Two species of chromatin-RNA polymerase II complex are commonly present in nuclei of various tissues of rats. | When rat liver nuclei were digested with nuclease, we found that the chromatin-bound RNA polymerase II was liberated as two distinct complexes, peak 1 and peak 2, which seemed to reflect different functional states in cell nuclei. We further examined their occurrence in nuclear digests of various tissues of rats and th... | ['Animals', 'Brain', 'Cell Nucleus', 'Chromatin', 'Electrophoresis', 'Kidney', 'Liver', 'Male', 'Protein Binding', 'RNA Polymerase II', 'Rats', 'Spleen', 'Testis'] | 6,526,808 | [['B01.050'], ['A08.186.211'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['E05.196.401', 'E05.301.300'], ['A05.810.453'], ['A03.620'], ['G02.111.679', 'G03.808'], ['D08.811.913.696.445.735.270.762'], ['B01.050.150.900.649.313.992.6... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Total quality management in accredited New South Wales hospitals: a public/private comparison. | Analysis of data collected in a 1994-95 survey of accredited New South Wales hospitals examined the adoption of key elements of total quality management practice in the public and private sectors. In a number of areas of practice widely considered to be central to a hospital's total quality management efforts, there wa... | ['Accreditation', 'Health Care Surveys', 'Hospitals, Private', 'Hospitals, Public', 'Humans', 'New South Wales', 'Organizational Policy', 'Total Quality Management'] | 10,178,130 | [['N03.706.110.070', 'N05.700.200.100'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['N02.278.421.481'], ['N02.278.421.510'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.639.100.750', 'Z01.678.100.373.750'], ['I01.655.500.550', 'I01.880.60... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
The hormonal response of patients with polycystic ovarian disease to subcutaneous low frequency pulsatile administration of luteinizing hormone-releasing hormone. | Four patients with oligoamenorrhea manifesting hormonal and clinical features of polycystic ovarian disease (PCOD) were selected for treatment. All patients had high luteinizing hormone (LH) levels and a basal LH/follicle-stimulating hormone (FSH) ratio of greater than 3. Three of them had high androgen levels with nor... | ['Adult', 'Androgens', 'Dehydroepiandrosterone', 'Dehydroepiandrosterone Sulfate', 'Estradiol', 'Female', 'Follicle Stimulating Hormone', 'Gonadotropin-Releasing Hormone', 'Humans', 'Injections, Subcutaneous', 'Luteinizing Hormone', 'Ovulation Induction', 'Polycystic Ovary Syndrome', 'Sex Hormone-Binding Globulin'] | 2,943,606 | [['M01.060.116'], ['D27.505.696.399.472.161'], ['D04.210.500.054.079.429.625', 'D04.210.500.578.502.400', 'D06.472.040.502.400', 'D06.472.334.851.968.952'], ['D04.210.500.054.079.429.625.300', 'D04.210.500.578.502.400.300', 'D06.472.040.502.400.300', 'D06.472.334.851.968.952.300'], ['D04.210.500.365.415.248', 'D06.472.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Genomic Analysis of Shewanella | Shewanella sp. O23S is a dissimilatory arsenate reducing bacterial strain involved in arsenic transformations within the abandoned gold mine in Zloty Stok (SW Poland). Previous physiological studies revealed that O23S may not only release arsenic from minerals, but also facilitate its immobilization through co-precipit... | ['Anti-Bacterial Agents', 'Arsenates', 'Bacterial Adhesion', 'Biofilms', 'Chromosomes, Bacterial', 'DNA Transposable Elements', 'Drug Resistance, Microbial', 'Genes, Bacterial', 'Genomics', 'Oxidation-Reduction', 'Phylogeny', 'Physical Chromosome Mapping', 'Plasmids', 'Shewanella'] | 30,813,619 | [['D27.505.954.122.085'], ['D01.075.025', 'D01.248.497.158.050'], ['G06.099.050'], ['A20.593', 'G06.120'], ['A11.284.187.190', 'A20.812', 'G05.360.162.190'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'], ['G06.225', 'G07.690.773.984.269'], ['G05.360.340.024.34... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Perceived health in 50-year-old women and men and the correlation with risk factors, diseases, and symptoms. | BACKGROUND: Population-based study of a random sample of 50-year-old men and women in Gothenburg, Sweden.OBJECTIVE: To examine the determinants of perceived health and the differences between 50-year-old men and women.METHODS: Men and women born in 1953 were examined between 2003 and 2004. Participation rate was 60% am... | ['Cardiovascular Diseases', 'Chronic Disease', 'Confidence Intervals', 'Female', 'Health Status', 'Health Status Indicators', 'Humans', 'Male', 'Middle Aged', 'Motor Activity', 'Multivariate Analysis', 'Odds Ratio', 'Prevalence', 'Risk Assessment', 'Risk Factors', 'Self Concept', 'Sex Factors', 'Smoking', 'Surveys and ... | 21,536,232 | [['C14'], ['C23.550.291.500'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['E05.318.308.980.438.475', 'N05.715.360.300.800.438.375', 'N06.850.520.308.980.438.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
A guide for mental health clinicians to develop and undertake benchmarking activities. | There is a growing expectation for staff to participate in benchmarking activities. If benchmarking projects are to be successful, managers and clinicians need to be aware of the steps involved. In this article, we identify key aspects of benchmarking and consider how clinicians and managers can respond to and meet con... | ['Benchmarking', 'Humans', 'Mental Disorders', 'Mental Health', 'Mental Health Services', 'Nurse Clinicians', 'Outcome and Process Assessment, Health Care', 'Program Development', 'United States'] | 20,367,651 | [['N04.452.500.150', 'N04.761.685.150', 'N04.761.700.150', 'N05.700.150', 'N05.715.360.650.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F02.418', 'N01.400.500'], ['F04.408', 'N02.421.461'], ['M01.526.485.650.648.525', 'N02.360.650.648.525'], ['N04.761.559', 'N05.715.360.575'], ['N04.452.760'], ['Z... | ['Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Toll-like receptor 2 mediates the induction of IL-10 in corneal fibroblasts in response to Fusarium solu. | Toll-like receptors (TLRs) are key components of the innate immune system that detect microbial infection and trigger antimicrobial host responses. To determine the role of TLR2 in the expression of pro- and anti-inflammatory cytokines in corneal fibroblasts challenged by fungi, we used siRNA specific for TLR2 to knock... | ['Animals', 'Cell Line, Transformed', 'Cornea', 'Eye Infections, Fungal', 'Fibroblasts', 'Fusarium', 'Gene Expression Regulation', 'Humans', 'Immunity', 'Interleukin-10', 'Interleukin-1beta', 'RNA, Small Interfering', 'Signal Transduction', 'Toll-Like Receptor 2'] | 18,195,725 | [['B01.050'], ['A11.251.210.172'], ['A09.371.060.217'], ['C01.150.703.320', 'C01.375.450', 'C11.294.450'], ['A11.329.228'], ['B01.300.381.366'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510', 'D23.529.374.465.510'], ['D12.644.276.374.465... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effects of artificial atmospheric ionization on thyroid gland in albino rat (author's transl)]. | Artificial atmospheric ionization acts on rat thyroid gland, but results are depending on treatment polarity: After negative aero-ionization, thyroid gland shows signs of high activity (increased area of follicular epithelium, increased volume of epithelial cell nucleus, and resorption of follicular colloidal material)... | ['Animals', 'Atmosphere', 'Cell Nucleus', 'Colloids', 'Ions', 'Male', 'Rats', 'Thyroid Gland'] | 1,217,867 | [['B01.050'], ['G16.500.275.063', 'N06.230.300.100'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['D20.280', 'D26.255.165'], ['D01.248.497'], ['B01.050.150.900.649.313.992.635.505.700'], ['A06.300.900']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Acute respiratory distress syndrome in two rhesus macaques (Macaca mulatta). | Acute respiratory distress syndrome (ARDS) is an important and potentially life-threatening complication in humans that arises subsequent to a variety of primary insults including noxious fume inhalation, infection, and trauma. Here we describe the first two cases of ARDS reported in association with postoperative comp... | ['Animals', 'Craniotomy', 'Macaca mulatta', 'Male', 'Postoperative Complications', 'Primate Diseases', 'Respiratory Distress Syndrome'] | 18,947,174 | [['B01.050'], ['E04.525.190'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['C23.550.767'], ['C22.735'], ['C08.381.840', 'C08.618.840']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
P-cadherin induces an epithelial-like phenotype in oral squamous cell carcinoma by GSK-3beta-mediated Snail phosphorylation. | Cadherins belong to a family of Ca(2+)-dependent homophilic cell-cell adhesion proteins that are important for correct cellular localization and tissue integrity. They play a major role in the development and homeostasis of epithelial architecture. Recently, it has become more and more evident that P-cadherin contribut... | ['Cadherins', 'Carcinoma, Squamous Cell', 'Cell Line, Tumor', 'Cell Movement', 'DNA, Neoplasm', 'Gene Amplification', 'Glycogen Synthase Kinase 3', 'Glycogen Synthase Kinase 3 beta', 'HeLa Cells', 'Humans', 'Immunohistochemistry', 'Kinetics', 'Mesoderm', 'Mouth Neoplasms', 'Neoplasm Invasiveness', 'Promoter Regions, Ge... | 19,654,099 | [['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['D13.444.308.425'], ['G05.308.250', 'G05.365.590.310', 'G05.558.315'], ['D05.500.117.875', 'D08.811.913.696.620.682.700... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Suppression of murine leukemia virus-mediated 3Y1 cell fusion by expression of mouse MHC class I. | Rat 3Y1 fibroblasts transformed by adenovirus type 12 or its E1A gene formed syncytia by cocultivation with Friend murine leukemia virus (MuLV)-producing cells. On the other hand, parental 3Y1 cells and those derivatives induced by other tumor viruses or chemical carcinogen showed no MuLV-mediated syncytium formation [... | ['Actins', 'Animals', 'Blotting, Northern', 'Cell Fusion', 'Cell Line, Transformed', 'Cell Transformation, Viral', 'Friend murine leukemia virus', 'H-2 Antigens', 'Mice', 'Promoter Regions, Genetic', 'Transfection'] | 1,863,224 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.242.307', 'G04.155'], ['A11.251.210.172'], ['C04.697.098.500.160', 'C23.550.727.098.500.160', 'G06.920.143'], ['B04.613.807.375.525.225', 'B04.820.650.375.525.225'], ['D23.05... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Feasibility and efficacy of verbal consents. | Refusal rates for participation in geriatric research have been surprisingly high. This may be due in part to inherent difficulties with a written consent procedure. A simple, easily administered, standardized verbal consent procedure (VCP) for the institutionalized elderly was developed to address this problem. Of 114... | ['Behavioral Research', 'Consent Forms', 'Geriatrics', 'Humans', 'Informed Consent', 'Research', 'Research Subjects', 'Speech', 'Therapeutic Human Experimentation', 'Writing'] | 2,236,896 | [['F04.096.144', 'H01.770.644.108'], ['I01.880.604.583.427.134', 'N03.706.535.489.134', 'N04.452.859.198', 'N05.715.360.300.715.245'], ['H02.403.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.473.650.718', 'I01.880.604.583.427', 'N03.706.437.650.312', 'N03.706.535.489'], ['H01.770.644'], ['M01.77... | ['Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Therapy for cervical cancer detected by mass screening. | Over a 19 year period since 1962, 972 cases of cervical cancer have been detected by mass screening in Miyagi Prefecture, a detection rate of 0.11%. Among these cases, 551 (56.7%) were cases of carcinoma in situ. In contrast, cervical cancers detected by means of private screening gave a detection rate of 0.39% (889 ca... | ['Carcinoma', 'Carcinoma in Situ', 'Female', 'Humans', 'Japan', 'Mass Screening', 'Uterine Cervical Neoplasms'] | 6,670,100 | [['C04.557.470.200'], ['C04.557.470.200.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['C04.588.945.418.948.850', 'C13.351.500... | ['Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Five questions about Streptococcus mutans: theoretical study of its transmission and colonisation. | PURPOSE: This theoretical study aimed to identify the decisive (and controllable) factors involved in Streptococcus mutans (Sm) infection through addressing questions about (i) the time and prevalence pattern (including the raison d'etre of the discrete period for the infection or WI) of initial Sm colonisation and (ii... | ['Humans', 'Infant', 'Models, Biological', 'Mouth', 'Streptococcal Infections', 'Streptococcus mutans'] | 22,541,733 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.599.395'], ['A01.456.505.631', 'A03.556.500', 'A14.549'], ['C01.150.252.410.890'], ['B03.353.750.737.872.875.520', 'B03.510.400.800.872.875.520', 'B03.510.550.737.872.875.520']] | ['Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Chemoresponsive Colloidosomes via Ag⁺ Soldering of Surface-Assembled Nanoparticle Monolayers. | Colloidosomes with a hollow interior and a porous plasmonic shell are highly desired for many applications including nanoreactors, surface-enhanced Raman scattering (SERS), photothermal therapy, and controlled drug release. We herein report a silica nanosphere-templated electrostatic self-assembly in conjunction with a... | ['Colloids', 'Gold', 'Metal Nanoparticles', 'Particle Size', 'Porosity', 'Silver', 'Spectrum Analysis, Raman', 'Static Electricity', 'Surface Properties'] | 25,866,989 | [['D20.280', 'D26.255.165'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['J01.637.512.600.500'], ['G02.712'], ['G01.374.710'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812'], ['E05.196.822.860', 'E05.196.867.890'], ['G01.358.500.249.820'], ['G02.860']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Restriction enzyme-mediated integration used to produce pathogenicity mutants of Colletotrichum graminicola. | We have developed a restriction enzyme-mediated insertional mutagenesis (REMI) system for the maize pathogen Colletotrichum graminicola. In this report, we demonstrate the utility of a REMI-based mutagenesis approach to identify novel pathogenicity genes. Use of REMI increased transformation efficiency by as much as 27... | ['Blotting, Southern', 'Colletotrichum', 'Genetic Complementation Test', 'Mutagenesis, Insertional', 'Plant Diseases', 'Plant Leaves', 'Plasmids', 'Protoplasts', 'Restriction Mapping', 'Transformation, Bacterial', 'Zea mays'] | 11,106,028 | [['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['B01.300.381.235'], ['E05.393.281.526'], ['E05.393.420.601.550', 'G05.365.590.575', 'G05.558.550'], ['G15.610'], ['A18.024.812'], ['G05.360.600'], ['A11.789'], ['E05.393.183.620.650', 'E05.393.712'], ['E05.393.350.810.500', 'G05.728.860.500', 'G05.728.865.820', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Qualitative systematic review of barriers and facilitators to self-management of chronic obstructive pulmonary disease: views of patients and healthcare professionals. | Self-management interventions for chronic obstructive pulmonary disease (COPD) can improve quality of life, reduce hospital admissions, and improve symptoms. However, many factors impede engagement for patients and practitioners. Qualitative research, with its focus on subjective experience, can provide invaluable insi... | ['Health Personnel', 'Humans', 'Motivation', 'Patients', 'Pulmonary Disease, Chronic Obstructive', 'Qualitative Research', 'Quality of Life', 'Self Care', 'Self-Management'] | 29,343,739 | [['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658', 'F01.752.543.500.750'], ['M01.643'], ['C08.381.495.389'], ['H01.770.644.241.850'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E02.900', 'I03.050.563', 'N02.421.784.680'], ['N02.421.784.760']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
New production of 5-bromotoluhydroquinone and 4-O-methyltoluhydroquinone from the marine-derived fungus Dothideomycete sp. | The addition of NaBr to the fermentation medium of a marine isolate of the fungus Dothideomycete sp. resulted in induced production of two toluhydroquinone derivatives, 5- bromotoluhydroquinone (1) and 4-O-methyltoluhydroquinone (2), and two known compounds, toluhydroquinone (3) and gentisyl alcohol (4). The structures... | ['Anti-Bacterial Agents', 'Culture Media', 'Free Radical Scavengers', 'Fungi', 'Hydroquinones', 'Inhibitory Concentration 50', 'Methicillin-Resistant Staphylococcus aureus', 'Microbial Sensitivity Tests', 'Molecular Structure', 'Spectrum Analysis'] | 22,297,222 | [['D27.505.954.122.085'], ['D27.720.470.305', 'E07.206'], ['D27.505.519.217.500'], ['B01.300'], ['D02.455.426.559.389.657.393'], ['E05.940.350', 'G07.690.936.563'], ['B03.300.390.400.800.750.100.500', 'B03.353.500.750.750.100.500', 'B03.510.100.750.750.100.500', 'B03.510.400.790.750.100.500'], ['E01.370.225.875.595', '... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of phosphorylation on phosphoenolpyruvate carboxykinase from the C4 plant Guinea grass. | In the C4 plant Guinea grass (Panicum maximum), phosphoenolpyruvate carboxykinase (PEPCK) is phosphorylated in darkened leaves and dephosphorylated in illuminated leaves. To determine whether the properties of phosphorylated and non-phosphorylated PEPCK were different, PEPCK was purified to homogeneity from both illumi... | ['Adenosine Triphosphate', 'Carbon', 'Carbon Dioxide', 'Cytosol', 'Electrophoresis, Polyacrylamide Gel', 'Immunoblotting', 'Light', 'Oxaloacetic Acid', 'Panicum', 'Phosphoenolpyruvate', 'Phosphoenolpyruvate Carboxykinase (ATP)', 'Phosphorylation', 'Photosynthesis', 'Plant Leaves', 'Zea mays'] | 11,788,762 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D01.268.150'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['E05.196.401.402', 'E05.301.300.319'], ['E05.478.566.320', 'E05.601.470.320'], ['G01.358.500.505.650... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[How do Ivorien rural populations perceive family planning?]. | The government of C?te d'Ivoire has recently adopted its population policy. One of the objectives of this policy is to reduce the high rate of population growth through family planning. The success of the family planning program will depend not only on the strength of effort to be deployed, but also on the acceptabilit... | ['Adult', "Cote d'Ivoire", 'Family Planning Services', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged', 'Public Policy', 'Rural Population', 'Surveys and Questionnaires'] | 12,471,920 | [['M01.060.116'], ['Z01.058.290.190.272'], ['N02.421.143.401', 'N02.421.800.249'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I01.655.500.608', 'I01.880.604.825.608', 'N03.623.500.608'], ['N01.600.725'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Immunohistochemical study of localization of extracellular matrix after holmium YAG laser irradiation in rat cornea. | PURPOSE: To better understand the corneal responses to holmium YAG (Ho:YAG) laser irradiation, we used immunofluorescent microscopy to examine changes in the localization of the extracellular matrix components, which play important roles in the maintenance of corneal morphology and functions.METHODS: Rats were irradiat... | ['Animals', 'Biomarkers', 'Collagen', 'Cornea', 'Corneal Stroma', 'Descemet Membrane', 'Epithelium, Corneal', 'Extracellular Matrix Proteins', 'Fibronectins', 'Fluorescent Antibody Technique', 'Laminin', 'Lasers', 'Male', 'Microscopy, Fluorescence', 'Rats', 'Rats, Inbred WKY'] | 11,033,125 | [['B01.050'], ['D23.101'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A09.371.060.217'], ['A09.371.060.217.228'], ['A09.371.060.217.271', 'A10.615.179.437'], ['A09.371.060.217.325', 'A10.272.510'], ['D12.776.860.300'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['E0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
P-glycoprotein and cytochrome P450 3A4 involvement in risperidone transport using an in vitro Caco-2/TC7 model and an in vivo model. | The possible involvement of P-glycoprotein (P-gp) and cytochrome P450 (CYP) 3A4 in risperidone transport was investigated using in vitro and in vivo models. Firstly, uptake studies were performed on a Caco-2/TC7 cell monolayer; the effects of 1 microg ml(-1) risperidone on apparent permeability were determined for secr... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Adenocarcinoma', 'Animals', 'Area Under Curve', 'Aryl Hydrocarbon Hydroxylases', 'Biological Transport', 'Cell Line, Tumor', 'Cytochrome P450 Family 4', 'Dopamine Antagonists', 'Dose-Response Relationship, Drug', 'Enzyme Inhibitors', 'Humans', 'Male', 'Mixed ... | 17,337,319 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['C04.557.470.200.025'], ['B01.050'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.83... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Behavioural disturbances following Japanese B encephalitis. | Clinically, Japanese B encephalitis (JBE) is often overlooked as its occurrence in Western countries is rare. However, its neurological, cognitive and psychiatric sequelae constitute a major public health problem in the Far East where JBE is endemic. European and American subjects may however experience the JBE when re... | ['Adult', 'Amnesia, Retrograde', 'Bipolar Disorder', 'Brain Damage, Chronic', 'Brain Stem', 'Cognition Disorders', 'Dementia', 'Diagnosis, Differential', 'Electroencephalography', 'Encephalitis, Japanese', 'Follow-Up Studies', 'Frontal Lobe', 'Humans', 'Impulsive Behavior', 'Male', 'Mental Disorders', 'Neurologic Exami... | 14,611,920 | [['M01.060.116'], ['C10.597.606.525.100.150', 'C23.888.592.604.529.100.150', 'F01.700.625.100.150', 'F03.615.200.150'], ['F03.084.500'], ['C10.228.140.140'], ['A08.186.211.132'], ['F03.615.250'], ['C10.228.140.380', 'F03.615.400'], ['E01.171'], ['E01.370.376.300', 'E01.370.405.245'], ['C01.207.245.340.300.400', 'C01.20... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Developmental responses to predation risk in morphologically defended mayflies. | Densities and species composition of predators could affect morphological defences, larval development and the timing of emergence of their prey. To address this issue we studied the morphology and life history of an ephemerellid mayfly, Ephemerella invaria, from two streams in a deciduous forested drainage basin in ce... | ['Adaptation, Physiological', 'Animals', 'Body Constitution', 'Female', 'Fertility', 'Fishes', 'Insecta', 'Larva', 'Male', 'Population Dynamics', 'Predatory Behavior', 'Risk Factors'] | 12,851,808 | [['G07.025', 'G16.012.500'], ['B01.050'], ['E01.370.600.115', 'G07.100'], ['G08.686.210'], ['B01.050.150.900.493'], ['B01.050.500.131.617'], ['B05.500.500', 'G07.345.500.550.500.500'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['F01.145.113.111.600', 'F01.145.113.252.520'], ['E05.318.740.600.800.725', 'N05... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Low back pain in pregnancy. | The aim of this case report is to discuss the subject of acupuncture in pregnancy and which acupuncture points, or areas, are safe to needle. Low back pain in a 21-year-old Caucasian primigravida at 24 weeks gestation was incapacitating and acupuncture was offered. Prior to pregnancy investigations had excluded a serio... | ['Accidents, Traffic', 'Acupuncture Points', 'Acupuncture Therapy', 'Adult', 'Female', 'Humans', 'Low Back Pain', 'Pregnancy', 'Pregnancy Complications', 'Risk Assessment', 'Time Factors', 'Treatment Outcome'] | 12,924,846 | [['N06.850.135.392'], ['E02.190.044.555.035'], ['E02.190.044'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612.107.400'], ['G08.686.784.769'], ['C13.703'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715']... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Paraphilic sexuality and child abuse: the parents. | The parents of three children with a history and diagnosis of abuse dwarfism responded to an interview on erotosexual history in such a way as to indicate a nondescript erotosexual existence, or else a censored one. One additional couple, known on a personal basis by a youth worker, colluded in child abuse that was, in... | ['Child', 'Child Abuse', 'Dwarfism', 'Female', 'Humans', 'Male', 'Masochism', 'Paraphilic Disorders', 'Parent-Child Relations', 'Self Disclosure'] | 7,097,787 | [['M01.060.406'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['C05.116.099.343', 'C16.320.240', 'C19.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.657.500'], ['F03.657'], ['F01.829.263.370.290'], ['F01.752.747.792.662']] | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
The Golgi rapid method in clinical neuropathology: the morphologic consequences of suboptimal fixation. | Cytologic changes in neurons of the neocortex of mice consequent to suboptimal fixation have been investigated systematically in Golgi-rapid preparations. With few exceptions, there is no alteration in cellular morphology if the brain is refrigerated after death, and fixed by immersion within 3 hours. With latencies of... | ['Adolescent', 'Adult', 'Aged', 'Animals', 'Astrocytes', 'Axons', 'Brain', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Middle Aged', 'Neurons', 'Postmortem Changes', 'Staining and Labeling', 'Time Factors'] | 73,572 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050'], ['A08.637.200', 'A11.650.200'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A08.186.211'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['B... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine â-synthase. | Acute pancreatitis is an inflammatory process of the pancreatic gland that may lead to dysregulation of the trans-sulfuration pathway. The aims of this work were firstly to study the methionine cycle as well as the trans-sulfuration pathway using metabolomic and proteomic approaches identifying the causes of this dysre... | ['Animals', 'Ceruletide', 'Cystathionine', 'Cystathionine beta-Synthase', 'Cysteine', 'Disease Models, Animal', 'Glutathione', 'Homocysteine', 'Male', 'Mice', 'Nitric Oxide Synthase Type II', 'Pancreatitis', 'S-Adenosylmethionine', 'Up-Regulation'] | 31,539,805 | [['B01.050'], ['D12.644.456.241'], ['D02.886.030.175', 'D12.125.095.307', 'D12.125.119.307', 'D12.125.166.175'], ['D08.811.520.241.300.200'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.644.456.448'], ['D02.886.030.498', 'D12.125.166... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Seroprevalence of human T-lymphotropic virus in blood bank donors at Fundaci?n Valle del Lili, Cali, Colombia, 2008-2014. | INTRODUCTION: Human lymphotropic virus (HTLV I/II) is a retrovirus that is prevalent across the Colombian Pacific coast, and is potentially transmissible by transfusion. Blood bank screening has been regulated since 2004, in order to reduce transmission of HTLV I/II through donation. Information on the seroprevalence o... | ['Antibodies, Viral', 'Blood Banks', 'Blood Donors', 'Blood Transfusion', 'Blotting, Western', 'Colombia', 'Cross-Sectional Studies', 'Disease Transmission, Infectious', 'Hepatitis B', 'Humans', 'Prevalence', 'Seroepidemiologic Studies'] | 27,622,800 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['N02.278.065.200'], ['M01.898.313'], ['E02.095.135'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['Z01.107.757.284'], ['E05.318.372.500.875', 'N05.715.360.330.500.87... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Protective effect of selenium on lung cancer in smelter workers. | A possible protective effect of selenium against lung cancer has been indicated in recent studies. Workers in copper smelters are exposed to a combination of airborne selenium and carcinogens. In this study lung tissue concentrations of selenium, antimony, arsenic, cadmium, chromium, cobalt, lanthanum, and lead from 76... | ['Aged', 'Humans', 'Lung', 'Lung Neoplasms', 'Metallurgy', 'Metals', 'Norway', 'Occupational Diseases', 'Risk', 'Selenium', 'Smoking'] | 4,041,390 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['J01.576.655.875.400'], ['D01.552'], ['Z01.542.816.374'], ['C24'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700', 'N06.850.520.830.600.800'], ['D01.268.185.850',... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Biodistribution of HuCC49DeltaCH2-beta-galactosidase in colorectal cancer xenograft model. | Antibody-enzyme conjugate (AbE) has been widely studied for site-specific prodrug activation in tumors. The purpose of this study is to characterize the pharmacokinetics and tissue distribution of HuCC49DeltaCH2-beta-galactosidase conjugate. HuCC49DeltaCH2 and beta-galactosidase were chemically conjugated and injected ... | ['Animals', 'Antibodies, Monoclonal', 'Antibodies, Neoplasm', 'Antigens, Neoplasm', 'Binding Sites, Antibody', 'Cell Line, Tumor', 'Colorectal Neoplasms', 'Colorimetry', 'Female', 'Glycoproteins', 'Humans', 'Immunoconjugates', 'Injections, Intravenous', 'Metabolic Clearance Rate', 'Mice', 'Mice, Nude', 'Tissue Distribu... | 19,944,136 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.240', 'D12.776.124.790.651.114.240', 'D12.776.377.715.548.114.240'], ['D23.050.285'], ['G02.111.570.060.425.079', 'G02.111.570.120.408', 'G12.122.232', 'G12.125'], ['A11.251.210.190', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
miR-133b Regulation of Connective Tissue Growth Factor: A Novel Mechanism in Liver Pathology. | miRNAs are involved in liver regeneration, and their expression is dysregulated in hepatocellular carcinoma (HCC). Connective tissue growth factor (CTGF), a direct target of miR-133b, is crucial in the ductular reaction (DR)/oval cell (OC) response for generating new hepatocyte lineages during liver injury in the conte... | ['2-Acetylaminofluorene', 'Adenoviridae', 'Aged', 'Animals', 'Carcinogens', 'Carcinoma, Hepatocellular', 'Cell Movement', 'Cell Proliferation', 'Connective Tissue Growth Factor', 'Disease Models, Animal', 'Down-Regulation', 'Female', 'Genetic Vectors', 'HEK293 Cells', 'Hep G2 Cells', 'Humans', 'Liver Neoplasms', 'Male'... | 26,945,106 | [['D02.065.064.150', 'D02.241.081.018.110.080', 'D02.455.426.559.847.389.050', 'D04.615.389.050'], ['B04.280.030'], ['M01.060.116.100'], ['B01.050'], ['D27.888.569.100'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.24... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Detection of genetic diversity and selection at the coding region of the melanocortin receptor 1 (MC1R) gene in Tibetan pigs and Landrace pigs. | Domestication and subsequent selective pressures have produced a large variety of pig coat colors in different regions and breeds. The melanocortin 1 receptor (MC1R) gene plays a crucial role in determining coat color of mammals. Here, we investigated genetic diversity and selection at the coding region of the porcine ... | ['Animals', 'Asia', 'Europe', 'Genetic Variation', 'Hair Color', 'Haplotypes', 'Open Reading Frames', 'Phylogeography', 'Quantitative Trait Loci', 'Receptor, Melanocortin, Type 1', 'Selection, Genetic', 'Swine', 'Tibet'] | 26,431,999 | [['B01.050'], ['Z01.252'], ['Z01.542'], ['G05.365'], ['G13.500', 'G16.690.490'], ['G05.380.360'], ['G05.360.335.760.640', 'G05.360.340.024.340.137.650'], ['H01.158.273.343.335.500', 'H01.277.500.589'], ['G05.360.340.024.380.937'], ['D12.776.543.750.695.430.500', 'D12.776.543.750.720.600.285.500.500', 'D12.776.543.750.7... | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo. | Deeper insight into the molecular pathways that orchestrate skeletal myogenesis should enhance our understanding of, and ability to treat, human skeletal muscle disease. It is now widely appreciated that nutrients, such as molecular oxygen (O2), modulate skeletal muscle formation. During early stages of development and... | ['Animals', 'Cell Differentiation', 'Cell Line', 'Gene Deletion', 'Gene Expression Regulation, Developmental', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'Immunohistochemistry', 'Ischemia', 'Mice', 'Mice, Inbred C57BL', 'Microscopy, Fluorescence', 'Muscle Development', 'Muscle, Skeletal', 'Mutation', 'Oxygen', 'Perfu... | 26,153,230 | [['B01.050'], ['G04.152'], ['A11.251.210'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.308.310'], ['D12.776.260.103.625.750', 'D12.776.930.125.625.750'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Noise suppression in training examples for improving generalization capability. | For the supervised learning problem, error correcting memorization learning was proposed in order to suppress noise in teacher signals. In this paper, generalization capability of the learning method is discussed. Generalization capability is evaluated based on the projection learning criterion. We give a necessary and... | ['Artifacts', 'Artificial Intelligence', 'Neural Networks, Computer'] | 11,411,632 | [['E05.047'], ['G17.035.250', 'L01.224.050.375'], ['G17.485', 'L01.224.050.375.605']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Detection of HERV-K(HML-2) viral RNA in plasma of HIV type 1-infected individuals. | Approximately 8% of the human genome sequence is composed by human endogenous retroviruses (HERVs), most of which are defective. HERV-K(HML-2) is the youngest and most active family and has maintained some proviruses with intact open reading frames (ORFs) that code for viral proteins that may assemble into viral partic... | ['Endogenous Retroviruses', 'HIV Infections', 'HIV-1', 'Hepatitis C', 'Humans', 'Molecular Sequence Data', 'RNA, Viral', 'Reverse Transcriptase Polymerase Chain Reaction'] | 17,067,267 | [['B04.613.807.250', 'B04.820.650.250', 'G02.111.570.080.708.330.800.175', 'G05.360.080.708.330.800.175', 'G05.360.340.024.425.800.175'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.650.350.400'], ['C01.221.250.750', 'C01.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Reactive Self-Assembly and Specific Cellular Delivery of NCO-sP(EO-stat-PO)-Derived Nanogels. | This study presents the reactive self-assembly of isocyanate functional and amphiphilic six-arm, star-shaped polyether prepolymers in water into nanogels. Intrinsic molecular amphiphilicity, mainly driven by the isophorone moiety at the distal endings of the star-shaped molecules, allows for the preparation of spherica... | ['Drug Delivery Systems', 'Fluorescent Dyes', 'HeLa Cells', 'Humans', 'Nanoparticles', 'Polyethylene Glycols', 'Polyethyleneimine'] | 29,974,620 | [['E02.319.300'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.637.512.600'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], ['D02.455.326.271.665.550.600', 'D02.491.65... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Light and electron microscopic distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and G86R mutant superoxide dismutase transgenic mice. | Excitotoxicity has been hypothesized to contribute to amyotrophic lateral sclerosis (ALS) neurodegeneration. The similar pattern of vulnerability in the spinal cord of mutant superoxide dismutase (SOD-1) transgenic mice and mice treated with excitotoxins supports a role for excitotoxicity in the mechanism of degenerati... | ['Amyotrophic Lateral Sclerosis', 'Animals', 'Calcium', 'Immunohistochemistry', 'Mice', 'Mice, Transgenic', 'Microscopy, Immunoelectron', 'Motor Neurons', 'Point Mutation', 'Receptors, Metabotropic Glutamate', 'Spinal Cord', 'Superoxide Dismutase'] | 9,619,504 | [['C10.228.854.139', 'C10.574.562.250', 'C10.574.950.050', 'C10.668.467.250', 'C18.452.845.800.050'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.15... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Contrast examination of the soft palate with cross sectional correlation. | In this exceptionally well illustrated article, the author demonstrates both the normal anatomy and the radiologic appearance of inflammatory, neurologic and neoplastic lesions of the soft palate. | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Squamous Cell', 'Eustachian Tube', 'Humans', 'Inflammation', 'Magnetic Resonance Imaging', 'Male', 'Methods', 'Palatal Muscles', 'Palatal Neoplasms', 'Palate, Soft', 'Radiography'] | 3,175,082 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A09.246.397.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['E01.370.350.825.500'], ['E05.581'], ['A02.633.567.750', 'A14.549.617.623'], ['C04.588.149.721.450.692', 'C04.588.443.59... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Late sensorial alterations in different radiotherapy techniques for nasopharyngeal cancer. | Intensity-modulated radiation therapy (IMRT) for nasopharyngeal cancer (NPC) allowed a better distribution of the dose to the tumor volume, sparing surrounding structures. Aim of the study is the objective evaluation of olfactory and gustatory impairments in patients who underwent chemo-radiotherapy for NPC. Correlatio... | ['Adult', 'Aged', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nasopharyngeal Neoplasms', 'Olfaction Disorders', 'Radiotherapy, Intensity-Modulated', 'Retrospective Studies', 'Taste Disorders'] | 25,800,268 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.443.665.710.650', 'C07.550.350.650', 'C07.550.745.650', 'C09.647.710.650', 'C09.775.350.650', 'C09.775.549.650'], ['C10.597.751.600', 'C23.888.592.763.550'], ['E02.815.635.700.700', 'L01.313.500.750.10... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Fate of estrogens in a municipal sewage treatment plant. | The fate of the highly potent endocrine disrupters estrone (E1), 17beta-estradiol (E2), and 17alpha-ethinylestradiol (EE2) was investigated in mechanical and biological sewage treatment as well as in sewage-sludge treatment at a municipal German sewage treatment plant (STP). The main outcome of the study was that a com... | ['Adsorption', 'Biodegradation, Environmental', 'Bioreactors', 'Endocrine System', 'Estrogens', 'Nitrogen', 'Oxygen', 'Sewage', 'Waste Disposal, Fluid'] | 14,524,430 | [['G01.030', 'G02.020'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['E07.115', 'J01.897.120.115'], ['A06'], ['D27.505.696.399.472.277'], ['D01.268.604', 'D01.362.625'], ['D01.268.185.550', 'D01.362.670'], ['D20.944.932.500'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Treatment with targeted vesicular stomatitis virus generates therapeutic multifunctional anti-tumor memory CD4 T cells. | A generally applicable, easy-to-use method of focusing a patient's immune system to eradicate or prevent cancer has been elusive. We are attempting to develop a targeted virus to accomplish these aims. We previously created a recombinant replicating vesicular stomatitis virus (VSV) that preferentially infected Her2/neu... | ['Adoptive Transfer', 'Animals', 'B-Lymphocytes', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Cell Line', 'Cytokines', 'Female', 'Genetic Vectors', 'Humans', 'Immunologic Memory', 'Mice', 'Mice, Inbred BALB C', 'Neoplasms', 'Vesicular stomatitis Indiana virus'] | 22,240,921 | [['E02.095.465.425.400.330.050', 'E05.478.550.520.050'], ['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence of heat-stable II enterotoxigenic Escherichia coli in pigs, water, and people at farms in Thailand as determined by DNA hybridization. | The DNA hybridization assay employing a 460-base-pair fragment of DNA encoding for the methanol-insoluble form of heat-stable toxin (ST-II) was used to determine the prevalence of ST-II enterotoxigenic Escherichia coli (ETEC) in pigs, people, and water at 57 farms in Sri Racha, Thailand. ST-II ETEC was found in 62 (3%)... | ['Animal Husbandry', 'Animals', 'Bacterial Toxins', 'DNA, Bacterial', 'Diarrhea', 'Enterotoxins', 'Escherichia coli', 'Escherichia coli Infections', 'Escherichia coli Proteins', 'Humans', 'Nucleic Acid Hybridization', 'Rectum', 'Swine', 'Swine Diseases', 'Thailand', 'Water Microbiology'] | 6,371,049 | [['J01.040.090'], ['B01.050'], ['D23.946.123'], ['D13.444.308.212'], ['C23.888.821.214'], ['D23.946.330'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['D12.776.097.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.661', 'G02.111.611'], ['A03.556.124.526.767', 'A... | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
Mcm2, Geminin, and KI67 define proliferative state and are prognostic markers in renal cell carcinoma. | PURPOSE: The origin licensing factors minichromosome maintenance 2 (Mcm2) and Geminin have recently been identified as critical regulators of growth and differentiation. Here we have investigated the regulation of these licensing factors together with Ki67 to further elucidate the cell cycle kinetics of renal cell carc... | ['Biomarkers, Tumor', 'Carcinoma, Renal Cell', 'Cell Cycle Proteins', 'Cell Proliferation', 'Female', 'Geminin', 'Humans', 'Immunohistochemistry', 'Ki-67 Antigen', 'Kidney Neoplasms', 'Male', 'Middle Aged', 'Minichromosome Maintenance Complex Component 2', 'Multivariate Analysis', 'Nuclear Proteins', 'Prognosis', 'Regr... | 15,814,627 | [['D23.101.140'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['D12.776.167'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.776.167.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.6... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Efficient genome ancestry inference in complex pedigrees with inbreeding. | MOTIVATION: High-density SNP data of model animal resources provides opportunities for fine-resolution genetic variation studies. These genetic resources are generated through a variety of breeding schemes that involve multiple generations of matings derived from a set of founder animals. In this article, we investigat... | ['Animals', 'Genetic Variation', 'Genome', 'Genomics', 'Genotype', 'Inbreeding', 'Pedigree', 'Polymorphism, Single Nucleotide'] | 20,529,906 | [['B01.050'], ['G05.365'], ['G05.360.340'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['G05.380'], ['E05.820.150.520', 'G05.090.403'], ['E05.393.673'], ['G05.365.795.598']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Trial of BCG vaccines in south India for tuberculosis prevention: first report--Tuberculosis Prevention Trial. | The protective effect of BCG vaccination is being evaluated in a controlled community trial near Madras in south India. After tuberculin and sensitin testing and radiographic and bacteriological examinations, BCG vaccines and placebo were allocated randomly to about 260 000 individuals, of whom 115 000 were definitely ... | ['Adolescent', 'Adult', 'Aged', 'BCG Vaccine', 'Child', 'Child, Preschool', 'Clinical Trials as Topic', 'Female', 'Humans', 'India', 'Infant', 'Infant, Newborn', 'Male', 'Middle Aged', 'Tuberculin Test', 'Tuberculosis'] | 396,057 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.