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Ans. a. Malignant otitis externa Presence of a painful lesion in the external ear with the evidence of granulation tissue and associated cranial nerve palsies (VII nerve) in a diabetic (or immunocompromised) patient suggest a diagnosis of malignant otitis externa.
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This patient is showing signs and symptoms of Myasthenia gravis. Edrophonium test is the most useful test in making a diagnosis of this condition because of the rapid onset and sho duration of its effect. This test is considered to be positive if there is any improvement in the weakness of this patient after administra...
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insensible water loss includes respiratory loss and water loss through skin Water loss through skin-350 Insensible loss through respiratory tract-350 Ref:Guyton and Hall textbook of medical physiology 12th edition pg 43
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Macleod syndrome It is also known as Swyer - Janes syndrome It is a cause of unilateral hyperlucent lung. It may present as acute pneumonia, but most patients are discovered when a chest X-ray is obtained for an unrelated reason. This not a true emphysema. On examination there is hyperresonance and a small lung with ...
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Inveed Papilloma/Schneiderian papilloma Arises from the lateral wall of nose Usually unilateral Affects male patients usually Clinically, men are affected more than women in 40-70yrs On examination of nose or endoscopy, it presents as a pale polypoidal mass resembling a simple nasal polyp. Endoscopic Endonasal excision...
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Ans. (a) Leydig cellRef: LB. Singh 9th ed. /14-16* Leydig cell secrete testosterone* Sertoli cells helps in maturation of spermatozoa* Epididymis:store sperm* Seminal vesicle: secretes thick alkaline fluid.
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Ans is 'a' i.e; Wegner's granulomatosis (WG) Antineutrophilic cytoplasmic antibody (ANCA)o ANCA are heterogenous group of autoantibodies directed against antigens which are found within the primary granules of neutrophil and in the lysosomes of monocytes and in EC's. The description of these autoantibodies is based on ...
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Ans. is 'b' i.e., Degenerative high axial myopia
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Ans. is 'd' i.e., Ciprofloxacin o The older agents used for the treatment of typhoid were;ChloramphenicolAmpicilinTrimethoprim Sulfamethoxazoleo These drugs are not used nowdays because o f widespread resistance.o Nowdays the drug of choice for Typhoid all over the world is a "Fluroquinolone" (Ciprofloxacin, ofloxacin)...
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Alcoholism, also known as alcohol use disorder (AUD), is a broad term for any drinking of alcohol that results in mental or physical health problems. The disorder was previously divided into two types: alcohol abuse and alcohol dependence. In a medical context, alcoholism is said to exist when two or more of the follow...
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Ans. (c) Not encapsulated.Ref: Bailey and Love 26th edition, Page 765* Most follicular cancers are capsulated.* Papillary cancer is also capsulated.* Sometimes rapidly growing follicular cancers will have no capsule.
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Proteins in the lens are unusually long lived and are thus subject to extensive and accumulated oxidative damage. The damaged proteins accumulate, aggregate, and precipitate; causing the lens to loose its transparency. Of critical impoance is the decrease in the Na+/K+ ATPase, resulting in the inability to maintain ste...
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This person most likely has an invasive adenocarcinoma of the colon involving the descending colon (a napkin-ring cancer), but above the rectum. The rich lymphatics of the descending colon drain through the mesentery to the inferior mesenteric nodes before draining to the lymphatics and nodes along the aoa. The gastroe...
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Alkali denaturation test (Apt-Downey test / apt test)Used to detect differentiate Fetal or neonatal blood from maternal blood (Qualitative).PrincipleMethodFetal hemoglobin (alpha 2 gamma 2 subunits) is resistant to alkali (basic) denaturation, whereas adult hemoglobin (alpha2 beta 2 subunits) is susceptible to such den...
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(Refer: DM Vasudevan, Textbook of Biochemistry, 7th edition, pg no: 249)
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Sporulation occurs in the latent period of bacterial growth due to potential of growth and multiplication
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In apoptosis chromosomal condensation, clumping, fragmentation, cell shrinkage, followed by cytoplasmic budding and phagocytosis of extruded apoptotic bodies occur.Since any products are not released directly rather than in apoptotic bodies an inflammatory reaction is not initiated in apoptosis. so option 1 is the answ...
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Ans. is a i.e. Laparoscopy Diagnostic laparoscopy is the gold standard for diagnosing endometriosis. Typical lesion : Powder burn / gun shot lesions (black, dark brown or bluish cysts with old hemorrhage surrounded by variable degree of fibrosis). Other non typical findings could be : - Red implantsdeg - Serous or clea...
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Hea rate is not used to decide for need for anticoagulation in case of Atrial fibrillation. Components of CHADS2-VASc score are: C Congestive hea failure 1 point H Hypeension 1 point A2 Age > 75 years 2 points D Diabetes 1 point S2 Stroke history 2 points V Vascular disease 1 point A Age > 65 years 1 point Sc Sex, cate...
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Hemorrhagic infarction is seen in: Hypercoagulable states (OCP use, pregnancy, polycythemia vera, malignancy, etc.) Embolism - Infarct is attributed to lysis of clot exposing infarct tissue and its permeable capillary bed to recirculating blood. Venous thrombosis.
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B i.e. Vesalius; C i.e. OvaleForamen Vesalius is an inconstant foramen that gives passage to an emissary vein that connects pterygoid venous plexus with cavernous sinus (vein of vesalius)Q. It is also k/a sphenoidal emissary foramen as its seen in the great wing of sphenoid, medial to foramen ovale, opposite the root o...
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Fever or hypothermia, leukocytosis or leukopenia, tachypnea (>20/minute), and tachycardia (>90/min) are the cardinal signs of systemic inflammatory response syndrome (SIRS). Ref: Harrison's Internal Medicine, 18th Edition, Chapter 271; Clinical Review of Surgery - ABSITE Preparation, 2nd Edition, Pages 286-7
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Latex agglutination test - cryptococcal capsular polysaccharide antigen can be detected in CSF, serum or urine by latex agglutination test. Ref: Textbook of Microbiology, Ananthanarayan and Paniker; 9th edition
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Lingual plate major connector should be supported anteriorly by rests, located on the mesial fossa of the first premolar on either side. Lingual plate extends upto the cingulum of the lingual surface of anterior teeth.
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In maternal diabetes fetal macrosomia is common. IUGR, if at all, is seen in neglected 'Burnt out' kind of diabetes with microangiopathy and is the last association which should come to mind with Diabetes in pregnancy Defn of IUGR: also called Fetal Growth Restriction ( FGR) Fetuses with estimated weight below the 10th...
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Ans. C: Epilepsy patients Clinical trials involving new drugs are commonly classified into four phases. Each phase of the drug approval process is treated as a separate clinical trial. The drug-development process will normally proceed through all four phases over many years. If the drug successfully passes through Pha...
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None
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Ans. C: Thrombocytosis According to its original description, TTP was defined as the pentad of fever, thrombocytopenia, microangiopathic hemolytic anemia, transient neurological deficits, and renal failure. Thrombotic thrombocytopenic purpura/TTP/Moschcowitz syndrome It is a rare disorder cauing extensive microscopic t...
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Verification of diagnosis is always the first step and writing repo is the last step of an epidemic investigation. Ref: Park's textbook of Preventive and Social Medicine, 21stedition, page-119
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From measuring cephalic index, race can be determined in 85-90% of cases. Mainly three types of races are there: Caucasian (white): Skull rounded, orbits triangular, nasal apeure elongated, palate triangular, upper and lower limbs normal in propoion to body. Mongolian (yellow): Skull square, orbits rounded, nasal apeur...
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- Given clinical features suggests the diagnosis of syndrome of inappropriate ADH (SIADH) secretion. SIADH - Associated with ADH excess, which causes resorption of excessive amount of free water, resulting in hyponatremia. - Causes of SIADH Secretion of ectopic ADH by malignant neoplasms (small-cell carcinomas of lung,...
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During pregnancy, due to increased vascularity and hyperemia there is bluish discoloration of vagina called as Chadwick sign. Ref: Datta Obs 9e pg 42.
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Ans. a (Thalassemia major) (Ref. Radiology Review Manual, 5th/pg.174)Causes of "hair on end" or "crew hair cut" skull are# Thalassemia (Characteristic)# Hereditary spherocytosis# Sickle cell disease# G-6-PD deficiency# Iron deficiency anaemia# Neuroblastoma
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Symptoms of carbon monoxide poisoning is as same as the case of hypoxia. Respiratory failure leads to alveolar hypoventilation leads to retention of CO2 and reduced lung compliance (Alveolar edema) also leads to CO2 retention.
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Refer KDT 6 /e p 609 Aspirin acts by inhibiting the enzyme cyclooxygenase
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Arsenic Mechanism of Action * Arsenic reversibly combines with sulphydrl enzymes. It blocks Krebs cycle and interrupts oxidative phosphorylation causing depletion of ATP and death of cell. * It also inhibits transformation of thiamine into acetyl CoA and Succinyl -CoA resulting in thiamine deficiency. * It replaces the...
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Ans. is 'c' i.e., 6-8 weeks Period of gestation and teratogenso Based on the gestation at exposure, a teratogen can either induce an embryopathy or a fetopathy.o From this perspective several critical periods of embryonic or fetal development are described:Preimplantation - fertilization to implantationEmbryonic - seco...
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A i.e. Time since death; C i.e. Skin is shrunked, dry & brown
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Best view for maxillary sinus → Water's view (occipito-mental view) Best view for frontal sinus     →  Caldwell view (occipito-frontal view) Best view for sphenoid sinus  →   Basal view (submentovertical view)
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Prilocaine causes less vasodilation than other local anesthetics and thus used without using epinephrine added to the local anesthetic solution.
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Anencephaly is a lethal NTD characterized by the absence of the brain and cranium above the base of the skull and orbits. It can be diagnosed as early as the first trimester on USG. Polyhydramnios is commonly seen due to the following reasons: a. Transudation of fluid across the membranes b. The absence of swallowing c...
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Please note that 110g/litre= 11g/dl A WHO expe group proposed that anaemia or deficiency should be considered to exist when haemoglobin is below the following levels: Cut-off points for the diagnosis of anaemia: AGE GROUP VENOUS BLOOD (g/dl) MCHC (%) Adult males 13 34 Adult females, non-pregnant 12 34 Adult females, pr...
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Ans. is 'b' i.e., Isolated IgA immunodeficiency(Ref: Harrison, 18th/e, p. 2704 and 17th/e, p. 2058)Selective IgA deficiency is the most common primary immunodeficiency, familial (more common), naive B cells are not able to differentiate into IgA producing cells. Along with IgA, IgG2 and IgG4 may also be reduced.
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The spleen may be moderately enlarged. Capsular fibrous thickening is common, as is follicular hyperplasia with numerous plasma cells in the red pulp. Central penicilliary aeries characteristically show thickening and perivascular fibrosis, producing onion-skin lesions. Robbins 9 th edition page no. 130
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Anti-Saccharomyces cerevisiae antibodies (ASCA) are immune proteins that are frequently present in people who have inflammatory bowel disease (IBD).Investigations are necessary to confirm the diagnosis, define disease distribution and activity, and identify complications. Full blood count may show anaemia resulting fro...
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Answer- D. 180 secProlonged seizure is defined as one that lasts for more than 3 minutes""Duration of more than 3 minutes is the criterion for prolonged seizures according to the American psychiatric association (1990)"
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Most common site of intra-peritoneal abscess is pelvis. Best option among the options provided is inferior space, right inferior intraperitoneal space.
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Ans. is 'c' i.e., Worm infestation
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Root value of musculocutaneous nerve is C5, C6.It arises from the lateral cord of brachial plexus.B D Chaurasia 7th edition Page no : 57
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Chemotaxis is defined as unidirectional movement of leukocytes up a concentration gradient of chemotactic molecules. All granulocytes, monocytes and to a lesser extent lymphocytes respond to chemotactic stimuli with varying rates of speed. Chemoattractants are exogenous or endogenous in nature. Exogenous agents are bac...
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Ans. is 'b' i.e., Atropine Pharmacological agents used for POAGA) Topical drugso b-blockers:- Timolol, betaxolol, levobunolol, carteolol.o Prostaglandin analogues:- Latanoprost, bimatoprost, travoprost.o Alpha agonists:- Non-selective (epipherine, dipivefrine); selective a2 (Apraclonidine, Brimonidine).o Carbonic anhyd...
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Implantation is the attachment of the blastocyst to the endometrium, and its subsequent embedding in the compact layer, occurring 6-7 days after feilization of the oocyte in humans. Blastocyst is a pre-implantation embryo consisting of a thin-walled hollow sphere of 16-32 cells, which appears in early mammalian develop...
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Osteoporosis is a group of disorders characterized by reduced bone mass or density in the absence of defect in bone mineralization. Dual energy X ray Absorptiometry (DEXA) scan is the gold standard method in the diagnosis of osteoporosis. It is a quantitative method for measuring bone mass by using low energy X ray bea...
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Ans. is 'a' i.e., B-cells Cell mediated (cellular) immunity ---)T-cells. Humoral immunity --o B-cells and antibodies.
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Ans. is 'd' i.e., Glaucoma Congenital rubella syndromeo Maternal viremia associated with rubella infection during pregnancy may result in infection of the placenta and fetus.o The most important factor in the pathogenicity of rubella virus for the fetus is gestational age at the time of infection. The earlier in pregna...
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In retrosternal goiter, resection of the goiter is carried out from the neck, a median sternotomy is sometimes needed. Cervical pa of the goiter is be mobilized first and retrosternal goiter is delivered by traction. Recurrent laryngeal nerve should be identified before delivering retrosternal goiter. Ref: Bailey and L...
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Movements lost in Erb's paralysis : - Abduction and lateral rotation of shoulder. Flexion and supination of the forearm. Biceps and supinator jerks are lost Sensations are lost over a small area over the lower part of deltoid.
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Refer Katzung 11/e p500 It is a prodrug and is activated BBy hepatic biotransformation to aldophosphamade. One of the degradation products is acrolein that is responsible for hemorrhagic cystitis
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De quervains thyroiditis is not of autoimmune etiology. It occurs several weeks following a viral illness with a prodrome of generalized myalgia, pharyngitis, low grade fever and fatigue. Viruses involved in causing this includes mumps, coxsackie, influenza, adeno virus and echo virus. Ref: Ultrasound of the Thyroid an...
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Refer Goodman Gilman 11/e p 1098 Transduction is paicularly impoant in transfer of resistance among staphylococci Multidrug resistant is transferred by conjugation
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When a squamous cell carcinoma (SCC) appears in scar it is known as Marjolins's ulcer. Ref: Bailey and Love's Sho Practice of Surgery, 22nd Edition, Page 133, 25th Edition, Page 611 and 23rd Edition, Page 148; Clinical Surgery By S. Das, Page 108.
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Ans. is 'd' i.e., Liver biopsy The given clinical picture is suggestive of either of the following diagnosis: Neonatal hepatiits Extra hepatic biliary atresia "Percutaneous liver biopsy is the most valuable procedure in the evaluation of neonatal hepatobiliary disease and provides the most reliable discriminatory evide...
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In M3,M3v subtype of AML there is high incidence of DIC Ref: Robbins pathologic basis of disease ; 8th edition; pg 622; table13-10
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Minerva cast is used in cervical spine
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Ranula is a cystic swelling in the floor of the mouth due to the obstruction of one or more ducts of the sublingual gland. It does not always represent a mucus retention cyst, it is more commonly a mucus extravasation cyst. It is neither a type of Epulis nor a type of thyroglossal cyst. Ref: The Medical Student's Vade ...
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Angioneuritic edema (Ref. Harrison 17th/e p 2066 & 16riVe p 52, 1952] Angioedema is essentially an anaphylaxis limited to the skin and subcutaneous tissues and can be due to drug allergy, insect stings or bites, desensitization injections or ingestion of ceain foods (paicularly eggs, shellfish or nuts) Sometimes reacti...
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Lisch nodules are hamartomas, located within the iris. They are characteristic of neurofibromatosis-1.
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Mode of transmission of cholera is by - faecally contaminated water. - contaminated foods and drinks. Reference : Park's textbook of preventive and social medicine, 23rd edition, pg no:230 <\p>
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LDH 1 is pre-dominantly present in RBCs and smooth muscle of heart, thus when RBCs are damaged, LDH1 is raised.
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Patient with acute pancreatitis have following C/F: Low grade fever Tachycardia Hypotension Severe abdominal pain of increasing intensity which radiated to back Bowel sounds become absent Bluish discolouration present in periumbilical area (cullen's sign), occurs because of hemoperitoneum Blue-red-purple or green-brown...
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Answer is C (Large veins of leg): About half the patients with pelvic vein thrombosis or proximal leg deep vein thrombosis have pulmonary thromboembolism. Isolated calf vein thrombosis pose a lower risk of pulmonary embolism- Harrisons
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Halothane decreases BP, HR & CO. There is no change on systemic vascular resistance.
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Right gastric aery originates from the hepatic aery just distal to the origin of gastroduodenal aery. It turns to the left and runs upwards along the the lesser curvature of the stomach and ends by anastomosing with the left gastric aery which is a branch of the coeliac trunk. Coeliac trunk: Arises at the level of inte...
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(a) Diplacusis(Ref. Cummings, 6th ed., 2556)Paracusis Willisii is paradoxical hearing better in noisy surroundings and is a feature of otosclerosisPresbycusis is age related hearing lossHyperacusis is normal sounds appearing louder and is a feature of facial nerve palsy
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Yaws is an endemic granulamatous disease caused by Treponema pallidum subspecies peunae. Yaws is also known as frambesia, pian or parangi. Infection occurs by direct contact. Primary lesions, also called mother yaw, develop at the site of inoculation, which enlarges and breaks down to form ulcerating granuloma. Similar...
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Prednisolone: It is a powerful anti-inflammatory agent. It acts by inhibiting the synthesis of PG, TX and LT the inhibition of phospholipase A2 enzyme. It is most impoant mechanism of anti-inflammatory action is the inhibition of chemotaxis.
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Dewey modified Angle’s Class I and III malocclusion by segregating malposition of anterior and posterior segments. CL I:  Type 1: Crowding of maxillary anterior teeth Type 2: Proclined maxillary incisors Type 3: Maxillary incisors are in crossbite Type 4: Posterior cross-bite Type 5: Mesial drift of molars CL II : (N...
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When to screen * Type-1 diabetes: Within 5 years of diagnosis. * Type-2 diabetes- Immediate fundus examination * MODY & GDM: Immediate
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Meconium stooling is seen in 90 percent of newborns within the first 24 hours, and most of the rest within 36 hours. The passage of meconium and urine indicates patency of the gastrointestinal and urinary tracts. Failure of the newborn to stool or urinate after these times suggests a congenital defect, such as imperfor...
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Only a modest change in molar relationship can be produced by this combination of differential growth of the jaws and differential forward movement of the lower molar. It must be kept in mind that the changes described here are those that happen to a child experiencing a normal growth pattern.  The transition in molar ...
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Ans. is 'c' i.e., CO2 & ''d' i.e., Nitrous dioxide Choice of Gas for pneumoperitoneum* First Pneumoperitoneum was created by filtered room air. Carbon dioxide 8c N2O are now preferred gas because of increased risk of air embolism with room air.* CO2 is used for insufflation as it is 200 times more diffusible than O2, i...
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Criteria for judging causality association of association of the association of association biological plausibility of the association. Ref: 25th edition, Park's Textbook of Preventive and Social Medicine, Page no. 97
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Ans. is 'b' i.e., Coxsackie B o The commonest cause of myocarditis is coxsackie B infection, which occurs any where from the age of a few hours to 7 weeks, with a peak around two weeks.
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Ans AThough not sensitive for subtle undisplaced or early fractures, plain radiographs even today due to their widespread availability, less radiation (as compared to CT scan), mobility (can be taken in any OPD/IPD/ICU) remain the mainstay of trauma imaging.
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ANSWER: (A) Avulsion fracture of base of fifth metatarsalREF: APPENDIX-68 below for "ALPHABETICAL LIST OF EPONYMOUS FRACTURES"Jones fracture is avulsion fracture of base of fifth metatarsal APPENDIX - 68Alphabetical List of Eponymous FracturesFractureDescriptionMechanism of injuryAviators fractureFracture neck of talus...
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CONSUMER  PROTECTION  ACT (CPA/COPRA) The  Consumer  Protection  Act,  1986  that came  into  force  on  15th  April  1987  is  a  JOTG & milestone  in  the  history  of  socio-economic legislation in the country. It is one of the most progressive  and  comprehensive  piece  of legislations  enacted  for  the  protecti...
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Answer is B (Reiter's syndrome): Ahropathy following recent travel suggests a probable diagnosis of Reactive ahritis secondary to organisms endemic in the zone of travel. The association of conjunctivitis (foreign body sensation in the eye) with ahritis suggests diagnosis of Reiter's syndrome.
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Increased arterial pressure in the upper limbs (as demonstrated in the brachial artery) and decreased pressure in the lower limbs (as demonstrated in the femoral artery) are common symptoms of coarctation of the aorta. Other symptoms include tortuous and enlarged blood vessels above the coarctation and an increased ris...
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Ans. is 'c' i.e., Hexose monophosphate shunt o HMP shunt is particularly important for two purposesi) Synthesis of ribose for nucleotide and nucleic acid formation.ii) Formation of NADPH which plays important role in several other biological processes, e.g. synthesis of fatty acids, cholesterol, steroid hormones and ne...
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Answer is A (Reiter's Syndrome): Syndrome is characterized by the triad of urethritis, conjunctivitis and ahritis.
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(A) Lateral Pterygoid # Lateral Pterygoid Actions:> Depresses the mandible to open the mouth, (with suprahyoid muscles).> Lateral and medial pterygoid muscles of both sides action together protrude the mandible.> Medial & lateral pterygoid muscles of the two sides contract alternately to produce side to side movements ...
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- Highly lipid soluble drugs get initially distributed to organs with high blood flow (Brain, heart, kidney etc). Later to less vascular tissues (muscle, fat). The plasma concentration falls and the drug is withdrawn from these sites. If the site of action was in one of the highly perfused organs, redistribution result...
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Gilbe syndrome causes unconjugated or indirect hyperbilirubinemia. Other options are the causes of conjugated hyperbilirubinemia. Other causes of unconjugated hyperbilirubinemia are hemolysis, bilirubin overproduction, physiological jaundice, breast milk jaundice, Crigler-Najjar syndrome, hypothyroidism, fasting. Refer...
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The adhesion of leukocytes to endothelial cells is mediated by complementary adhesion molecules on the two cell types whose expression is enhanced by secreted proteins called cytokines. Cytokines are secreted by cells in tissues in response to microbes and other injurious agents, thus ensuring that leukocytes are recru...
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Ans. is 'a' i.e., Promoter region
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Ans. is 'b' i.e., 5th metacarpal neck * Boxers' fracture: It is a ventrally displaced fracture through the neck of the 5th metacarpal, usually occurs in boxers.
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Ans. A. CCTA* Coronary lesions prone to rupture and subsequent development of MI have different morphology compared with stable plaques and can be evaluated by CCTA to identify vulnerable plaques before they lead to clinical events. Large plaque volume, low CT attenuation, napkin- ring sign and spotty calcification are...
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Ans. B: Binocular lesion Amaurosis fugax is due to a transient decrease in blood supply to the eye or the optic nerve. It occurs commonly when a piece of plaque (embolus) in the carotid aery breaks off and travels to the retinal aery in the eye. Plaque is a hard substance that forms when fat, cholesterol and other subs...
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11 beta hydroxylase deficiency Androgen excess- masculinization of female newborns and precocious pubey in male Hypeension, which may or may not be associated with mineralocoicoid excess, hypokalemia, and metabolic alkalosis Liddle syndrome AD, hypeension associated with low plasma renin activity, metabolic alkalosis, ...
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