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Cushing's triad is the classic presentation of raised intracranial pressure which consists Hypeension Bradycardia Irregular Respirations
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Metabolism of Cornea *Main Metabolic pathway: Aerobic *Ascorbic acid transpo: Na K ATPase > Myoinositol *Cornea becomes edematous due to lactate accumulation that happens during hypoxic conditions such as prolonged contact lens use. *Oxygen is derived from environment & glucose from aqueous humor. *Vitamins and amino a...
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CRANIAL NERVE Optic nerve arises from ganglion cell axons. *Length = 47-50mm. *Can be considered as pa of brain *3rd order neuron *Protected by meninges *Pas: Intraocular, Intraorbital, intracanalicular, intracranial *Smallest pa of optic nerve is intraocular *Longest pa : Intraorbital Order of Neurons *Rods & Cones (P...
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Ans. is 'a' i.e., Rhinophyma o Rhinophyma is large, bulb-shaped, red-colored (ruddy) nose. It is a slow growing benign tumor due to hypertrophy of the sebaceous glands.o Has been explained in previous sessions.
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Pulmonary aery hypeension The forced vital capacity (FVC) is not decreased in this case. The forced vital capacity in the question is FVC 93% is normal. - (Any pulmonary. function test which is 80-100% of the predicted value is considered normal) The FEV I is also mentioned as normal. So, the only pulmonary function ab...
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Ans is 'a' i.e. T.B spine * Cold abscess is a feature of bone tuberculosis and spine is the most common site of bone TB (about 50%)Rib tuberculosis is very rare.These lines from Tuli further support the answer."Abcess or sinuses from the cervical or dorsal regions can present themselves far away from the vertebral colu...
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Pugilistic attitude or boxer's attitude this occurs due to coagulation of the muscle proteins resulting in contraction of muscle fibers. As the flexors are bulkier than extensors, they contract more and force the body to attain such an attitude. Ref: TEXTBOOK OF FORENSIC MEDICINE AND TOXICOLOGY KRISHNAN VIJ FIFTH EDITI...
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Tropomyosin Molecules: The actin filament also contains tropomyosin. Each molecule of tropomyosin has a molecular weight of 70,000 and a length of 40 nanometers. These molecules are wrapped spirally around the sides of the F-actin helix. In the resting state, the tropomyosin molecules lie on top of the active sites of ...
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ithium was introduced by JOHN F CADE it is used in treatment of MANIA it is a liver friendly drug it has to be used in caution with people with deranged renal parameters if the patient is on lithium, he should be warned about of intake of other meds like NSAIDS, ACE inhibitors , as it may result in toxicity if a patien...
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A major advance in the management of PNH has been the development of a humanized monoclonal antibody, eculizumab, directed against the complement component C5. By blocking the complement cascade downstream of C5, eculizumab abrogates complement-dependent intravascular hemolysis in all PNH patients. Reference: Harrisons...
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substrate level phosphorylation-- Enzyme phosphoglycerate kinase- Enzyme pyruvate kinase.
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The most common site for dural fistula is in the anterior cranial fossa, in the area of the cribriform plate. Here, the bone is very thin and the dura is tightly adherent to the bone. A fracture in this area allows CSF to leak through torn arachnoid and dura into the nasal cavity, resulting in CSF rhinorrhoea.
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A i.e. Ipsilateral loss of joint sensation
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Mineral oils are used as chemical control against mosquito larvae. The mineral oil application to water is the oldest method to control mosquito. oils used are diesel oil, fuel oil, kerosene oil, and crude oils. Special mosquito larvicidal oils are also available. Oil kills larvae and pupae within a sho time after appl...
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The Left recurrent laryngeal nerve has a longer course to the neck than the right side. This is because it hooks under the left sixth arch aery which persists in extra-uterine life as the ductus aeriosus, a fibrous remnant. On the right side, neither the sixth nor fifth arch aeries persist and so the recurrent laryngea...
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D i.e. Drug has entered the sub arachnoid space
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Ans. is 'b' i.e., Microglia
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Choroidal effusion syndrome (ciliochoroidal effusion) It is characterized by: - Thick sclera (main feature), ciliochoroidal detachment ( abnormal accumulation of serous fluid in outer layer of ciliary body and choroid). - Absence of inflammation and neoplastic disease. - Eyes may be nanophthalmic or hypermetropic. - Le...
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When the infant's weight is above the ninetieth percentile, the infant is considered large for gestational age. It can be a consequence of genetic predisposition with similar large infants in previous pregnancies of the mother. Glucose crosses the placenta but insulin cannot. Consequently, fetal hyperglycemia and hyper...
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Cerebral malaria involves the clinical manifestations of Plasmodium falciparum malaria that induce changes in mental status and coma and is accompanied by fever. Without treatment, cerebral malaria is fatal in 24-72 hours and the moality ratio is between 25 to 50 percent. The common histopathologic finding is the seque...
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Retinitis Pigmentosa: It is a group of heterogeneous hereditary rod-cone dystrophies characterized by progressive dysfunction of the photoreceptors, associated with progressive cell loss and eventual atrophy of retinal layers. It occurs sporadically or in an autosomal recessive, dominant, or X-linked pattern. Hallmark ...
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Ans: B (20 weeks) Ref: The Essentials of Forensic Medicine and Toxicology by KS Narayan Reddy, 29th edition, 2010, pg: 381Explanation:The Medical Termination of Pregnancy (MTP) Act of IndiaIt clearly states the conditions under which a pregnancy can be ended or aborted, the persons who are qualified to conduct the abor...
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Gemcitabine is currently the standard of care for patients with metastatic pancreatic cancer.
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Ans. is 'a' i.e.,MCLo Injuries from lateral side of knee causes valgus stress, resulting in injury to medial collateral ligament,o Conversely, injury' from medial side of knee causes varus stress and injury to lateral collateral ligament.
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pH- 7.25 (acidic) PCO2 - 68 mm Hg (respiratory acidosis) HCO3 - 31 mm Hg (elevated) - but pH acidic - So paially compensated
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Lymphoedema may be defined as abnormal limb swelling caused by the accumulation of increased amounts of high protein ISF secondary to defective lymphatic drainage in the presence of (near) normal net capillary filtration. At bih, 1 in 6000 people will develop lymphoedema with an overall prevalence of 0.13-2%.The severi...
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Interstitial poion Impoant Facts about Fallopian Tube : 1. Length = 4 inches or 10 - 12 cms. 2. Pas are : a. Interstitium (Intramural) : 1.8 cm long and 1 mm diameter (narrowest padeg). It has no longitudinal muscles, only circular muscles are present.deg Isthmus 3.5cm long and 2mm in diameter.deg Ampulla : widestdeg a...
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Ans. is 'c' i.e., Thrombi in pulmonary vasculature Pulmonary Hypeension o In pulmonary hypeension pathological changes are seen from main pulmonary aeries to aerioles. They are : (a) Aerioles and small pulmonary aeries : (i) Medial hyperophy (ii) Thickening and reduplication of elastic lamina. (iii) Plexiform pulmonary...
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Ans. is 'c' i.e., Serratia Marcesens
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A mycetoma like condition called botryomycosis is caused by staphylococcus aureus.
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Ans. is'c'i.e., Gastrocolic reflex[Rel Guyton llth/e p. 771)Appearance of mass movements after a rneal is facilitated by gastrocolic and duodenum reflexes.These reflexes result from the distension of the stomach and duodenum.The best example of gastrocolic reflex is seen in early infancy where defecation often follows ...
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Ans. is 'd' i.e., Achillis tendinitis Heel pain when walking up hill or up stairs is typical of Achillis tendinitis. Other three options can also cause heel pain, but pain in these conditions has no relation to going up or down. It is consitent throughout.
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IMPOUNDING RESERVOIRS- These are aificial lakes constructed usually of eahwork or masonry in which large quantities of surface water is stored. Dams built across rivers and mountain streams also provide large reserves of surface water. The area draining into the reservoir is called "Catchment area".
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Pneumatosis Intestinalis is the presence of intramural air seen in Stage IIb of Necrotising Enterocolitis / Intestinal ischemia.
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The blue or white translucent plastic bag is used for sharps (needles, syringes, scalpels, blades, glass etc. that may cause puncture or cuts) and solid wastes such as waste generated from disposable items like tubings, catheters, intravenous sets etc. These wastes are treated by autoclaving/microwaving/chemical treatm...
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Ans. b. Azithromycin 2 gm statMonotherapy with 2 g oral azithromycin has been proven to be effective in patients with noncomplicated gonorrheal infections, but this is no longer recommended because of concerns of resistance to macrolides and documented treatment failures.Given the growing resistance patterns of gonorrh...
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Thalidomide
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Eosinophilic pustular Folliculitis is most prevalent in HIV infection and is seen in ~20% of patients. m/c in patients with CD4+ T cell counts <200 cells/mL Presents as multiple, uicarial perifollicular papules that may coalesce into plaque like lesions. Skin biopsy reveals an eosinophilic infiltrate of the hair follic...
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Soft tissue sarcoma metastasing to bone are : - Alveolar soft  part sarcoma                                                                         Liposarcoma Angiosarcoma Rhabdomyosarcoma Synovial cell sarcoma  Osteosarcoma can metastasize to bone; However, it is a bone tumor (question has been specifically asked...
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Ans. is 'b' i.e., Hvdatid cyst Man acts as intermediate host for : ? Plasmodium (malaria) Toxoplasma Echinococcus granulosus (hydatid disease)
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Blue sclera is not seen in Keratoconus It is seen in all conditions like Marfans syndrome Rheumatoid ahritis Osteogenesis imperfecta. Refer: Khurana 6th edition page number 144
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Radioactive iodine (131-I) is a radioactive isotope that is administered orally, in a liquid or capsule form.Thyroid tissue concentrates iodine. For this reason, 131I can be given in order to deliver tumoricidal doses of radioactivitydirectly to thyroid tissue, both benign and malignant. In the setting of thyroid cance...
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Dermatiaceous Fungus Involves skin & sub cutaneous tissues Sclerotic bodies seen in tissue biopsy Brown colored lobose bodies Aka medlar bodies Show copper penny appearance Examples - 1) Philophora 2) Cladosporium
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Atrial pressure rises during atrial systole and continues to rise during isovolumetric ventricular contraction when the AV valves bulge into the atria. When the AV valves are pulled down by the contracting ventricular muscle, pressure falls rapidly and then rises as blood flows into the atria until the AV valves open e...
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Absolute indications for surgical treatment of BPH 1) Refractory urine retention (failing at least one attempt at catheter removal 2) Recurrent UTI from BPH 3) Bladder stones d/t BPH 4) Renal insufficiency d/t BPH 5) Large bladder diveicula secondary to BPH 6) Recurrent gross hematuria from BPH Ref : Cambell's Urology ...
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ANSWER: (A) Radial nerveREF: Gray's anatomy 39th edition page 858See APPENDIX-7 below for "BRACHIAL PLEXUS LESIONS"Lesions of the radial nerve in the upper arm:Lesions of the radial nerve at its origin from the posterior cord in the axilla may be caused by pressure from a long crutch (crutch palsy). Triceps is only inv...
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Ans. is 'a' i.e., Choristoma o Normally arranged tissue at a different anatomical site (ectopic site) --> Choristoma. o Abnormally arranged tissue present at normal site -->Hamaoma
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Ref. Sabiston Textbook of Surgery. Pg. 142   Keloid  is the type of abnormal scar formation  and it is most commonly confused with hypertrophic scar . Keloid scars resemble hypertrophic scars superficially in that they are elevated boundary of the original injury or incision . Males and females equally prone to keloid...
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Giemsa stained thin blood films are examined for demonstration of intraerythrocytic parasite.in humans ring forms of babesia may be mistaken for P.falciparum although the presence of tetrad forms(MALTESE CROSS) in the erythrocytes and absence of hemozoin are diagnostic REF:TEXTBOOK OF MEDICAL PARASITOLOGY,BAVEJA,3RD ED...
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Effects and complications of Gallstones In gallbladder In Bile duct In Intestine Silent stones Acute cholecystitis Chronic cholecystitis Mucocele Empyema Perforation Gangrene Carcinoma Obstructive jaundice Cholangitis Acute pancreatitis Gallstone ileus Ref: Sabiston 20th edition Pgno : 1492-1493
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D i.e. Stratum corneum
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Esophageal dysmotility is the "E" in CREST syndrome, the limited form of systemic sclerosis (i.e., scierodernia). Although this disease is autoinmiune in nature, little inflammation is seen by the time the patients come to clinical attention. There is increased collagen deposition in submucosa and muscularis. Fibrosis ...
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Blood at the meatus is suspicious of urethral injury and an immediate urethrography is advised to rule out any urethral injury. The cauterization is not done until urethral injury is ruled out. So among the given options in the question, none seems to be correct. But have a look at what Bailey writes - "Very occasional...
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Wait for spontaneous expulsion
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Ans. (c) Vinyl chloride(Ref: Robbins 9th/pg 870)Angiosarcoma of liver is associated with vinyl chloride, arsenic or Thorotrast exposure & has poor prognosis
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Tuberous sclerosis is a autosomal dominant condition characterized by development of hamaomas and benign neoplasms involving the brain and other tissues. The most frequent clinical manifestations are seizures, autism,and mental retardation. Hamaomas within the CNS take the form of coical tubers and subependymal nodules...
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Chronic, painful diabetic neuropathy is difficult to treat but may respond to duloxetine, amitriptyline, gabapentin, valproate, pre- gabalin, or opioids. Two agents, duloxetine and pregabalin, have been approved by the U.S. Food and Drug Administration (FDA) for pain associated with diabetic neuropathy, but no treatmen...
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Lymphomas are progressive neoplastic condition of lymphoreticular system arising from stem cells. Lymphomas are the 3rd most common malignancy among children comprising 15% of paediatric cancers. Primary lymphoma of the GI tract associated with Celiac sprue--intestinal T cell lymphoma. Reference : page 253 SRB's manual...
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Ans. is 'b' i.e., Zygomatiomaxillary fracture o Zygomaticomaxillary complex (ZMC) fractures, also known as a tripod, tetrapod, quadripod, malar or trimalar fractures, are seen in the setting of traumatic injury to the face. They comprise fractures of the:# Zygomatic arch# Inferior orbital rim, and anterior and posterio...
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Ans. is 'c' i.e., Thoracodorsal nerve * Thoracodorasal nerve (C6-8) is a branch of posterior cord of the brachial plexus that supplies the latissimus dorsi muscle. It is also known as the nerve to latissimus dorsi.
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Ans. is b, i.e. PPHRef: Textbook of Prenatal Medicine by Kurjak and Chervenak 2/e, p 1945Friends - the most common of rapid death in obstetrics is PPH. In PPH, we can lose a patient within minute"In sharp contrast to APH, which usually claims life after 10 hrs if left untreated. PPH kills swiftly often in less than 2 h...
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Grisel's syndromeSpontaneous subluxation of the atlantoaxial joint following peri-pharyngeal inflammation is known as Grisel's syndrome Children are most frequently affected and classically have toicollis associated with neck stiffness or pain upon neck movement(Refer: Nelson's Textbook of Pediatrics, SAE, 1st edition,...
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Ans. is `b' i.e., Selenium
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Ans. is 'a' i.e., Cinnarizine Veigo is due to labyrinthine disorder and the impulse utilizes cholinergic muscarinic and H1 histamic receptors (similar to motion sickness). So, the drugs used are antimuscarinic, phenothiazines (phenothiazines have anticholinergic propey) and antihistaminics. Cinnarizine (act by inhibiti...
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Bone & cartilage are radioresistant. Ewing's sarcoma, seminoma and GI epithelium are highly radiosensitive.
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Methanol is initially metabolized by alcohol dehydrogenase to formaldehyde, with subsequent oxidation to formic acid, then to CO2 & water. Formic acid is responsible for metabolic acidosis with increased anion gap & renal toxicity.
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Ans. is 'b' i.e., 4%The recurrence risk of neural tube defect is :3 - 5 % if a couple has previously had a child with either anencephaly or spina bifida.5% if either parent was born with a NTD.10% if a couple has two affected children
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Sch can cause dangerous hyperkalemia in burn, massive trauma, Crush injury ,Severe intraabdominal infection(sepsis),spinal cord injury, hemiplegia / paraplegia, muscular dystrophy ,GB syndrome, Rhabdomyolysis, Myasthenia Gracia, tetanus, severe parkinsonism,polyneuropathy,closed head injury, stroke ,encephalitis. Ref: ...
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Parapharyngeal abscess is a lateral swelling (not midline).
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St. Louis encephalitis virus is spread by mosquitoes and causes a severe encephalitis with a near 10% fatality rate. Colorado tick fever, spread by the wood tick, causes fever, headache, retro-orbital pain, and severe myalgia. Fever and jaundice characterize yellow fever, a life-threatening disease spread by mosquitoes...
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The disease is most common in preschool children; infants are protected by transplacental antibodies, which generally decay by 9 months The prodromal phase is characterized by fever, rhinorrhea, conjunctiva! congestion and a dry hacking cough. Koplik spots, considered as pathognomonic of measles, appear opposite the lo...
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Ref: Park 25th edition Pgno : 692
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Quadrilateral cailage or septal cailage forms the nasal septum. As seen in above figure the aerior side of this cailage forms the dorsum of External nose. It comes in contact with perpendicular plate of ethmoid,vomerand aerior nasal spine. Ref.Dhingra 6/e,p 147.
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All of the above REF: Harrison 17th ed p 1261, International Journal of Infectious Diseases Volume 15, Issue 8, Pages e533-e540, August 2011 Mucormycosis Caused by -- rhizopus , rhizomucor , cunninghamella Moulds with non septate hyphae The higher prevalence of mucormycosis in India turned out to be statistically signi...
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Ans. D: Chronic glomerulonephritis Chronic kidney disease is long-standing, progressive deterioration of renal function. Symptoms develop slowly and include anorexia, nausea, vomiting, stomatitis, nocturia, lassitude, fatigue, pruritus, decreased mental acuity, muscle twitches and cramps, water retention, under nutriti...
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The structures forming the three bony point around the elbow are medial epicondyle, lateral epicondyle and tip of olecranon. Normally in an elbow flexed at 90 degree these three points forms a near isosceles triangle. Base is formed by the line joining the two epicondyles. The three points lies in a straight line when ...
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Ans. is 'b' i.e., Posterior fossa volume To under stand this question you are required to know the basics of CSF production and drainage. o Both Aqueductal stenosis and Dandy Walker cause non communicating hydrocephalus but the site of obstruction is different. o Let us see the causes of hydrocephalus in Aquedutal sten...
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Ans. is 'b' i.e., SLE [Ref: Robbins 9th/e p. 562 & 8th/e p. 569)Libman Sack's endocarditis* It is seen in SLE and is characterized by small/medium sized, sterile, flat, Verrucous vegetations occurring on both (atrial and ventricular) surfaces of valve, which may extend to chordae tendinae and mural endocardium.* They m...
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Etomidate is an induction anaesthetic which cause suppression of production of steroids from adrenals. It is therefore not suitable for continuous intravenous use. It has brief duration of action (5-10min) and produce little cardiovascular and respiratory depression. It produce prominent motor restlessness and rigidity...
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Ans. is a i.e. Kallman Syndrome Friends, you know the answer to this question quite well. Here I would like to point out that in solving PGMEE Questions of previous years, it is not only impoant to know the correct answer with its details, it is equally impoant to know the details of incorrect options (as Questions mig...
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The human nasopharynx is the only reservoir of the Meningococcus. Natural infection is limited to the nasopharynx. Asymptomatic nasopharyngeal carriers rarely contract the illness but serve right infect their contacts. During the inter-epidemic period, the carrier rate is 5-10 percent. An increase in carriers rate hera...
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Refer Robbins 9/e p479 the percentage of each component is variable (Fig. 10-29A). Sheets of small blue cells with few distinctive features characterize the blastemal component. Epithelial differentiation is usually in the form of aboive tubules or glomeruli. Stromal cells are usually fibrocytic or myxoid in nature, al...
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Ans. (a) CMV Ref. Nelson 17/e, p 568, 623, 626, 631 Transplacental transmission occure in Viruses Rubella CMV HSV Varicella zoster virus Parvo B - 19 Coxasackie viruses HIV West nile virus Coxasackie viruses HBV and HCV Measles Bacteria Syphilis TB Brucella Parasite Plasmodium T. cruzi Microsporidia Toxoplasma
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Ans. is 'a1 i.e., Increases HDL Nicotinic acid (Niacin)o There are three main type of lipases related to metabolism of lipoproteins -1. Lipoprotein lipase - Present in blood vessels and causes hydrolysis of tryglvceride content of VLDL and chylomicrones.2. Hepatic lipase - Converts IDL to LDL by hydrolysing the triglyc...
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Risk factors for HELLP (hemolysis with elevated liver enzymes and low platelets) syndrome, a variant of severe preeclampsia, include nulliparity, advanced maternal age, diabetes mellitus, preexisting hypertension, a prior history of preeclampsia, and renal disease. Patients with HELLP syndrome may progress to dissemina...
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Ans. d. (All of the above). (Ref. Parsons, disease of Eye, 19th /296, Basak, Ophthalmology, 2nd/324)IOL# IOL implantation was first performed by Dr. Harold Ridley (1949).# Material used for manufacturing IOL:Optic materialHaptic materialNon foldableFoldablePolypropylene PMMAAcrylicPolymethyl methacrylate (PMMA)Silicone...
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Ans. C: Amoxapine One of major metabolites of amoxapine, 7-hydroxyamoxapine, has a dopamine receptor blocking effect, making this drug a common cause of neuroleptic malignant syndrome. Amoxapine is also associated with acute extrapyramidal symptoms and tardive dyskinesia.
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Ans. is 'b' i.e., Cytosine Arabinoside Dihydrofolate reductase antagonists are o Methotreyate o Pentamidine o Trimethoprim o Pyrimetham ne
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Classic 21 α hydroxylase deficiency is the most common cause of Ambiguous genitalia in a new born. Pseudo hermaphroditism A congenital abnormality of the external genitalia and of the body in which one possesses sex glands of one sex but genitals of the opposite sex.
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A i.e. Cistron
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Ans. c. Fish net IgG deposition in epidermis (Ref: Fitzpatrick ~ e p432-441: Rooks 8/ep40.27, 13.19, 10.12-10.28)A 30-year-old male presents with flaccid bullae on an erythematous base and erosions over the oral mucous membrane. The blisters developed painful erosions rupture. The clinical features point towards a diag...
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Ans. is a i.e. Lovset's method Friends amongst malpresentations - Breech is the most frequently asked - "Many question are asked on Breech. So, 1 am summarising ail the impoant points you need to know about breech." Breech Most common cause prematurity. Most common type of Breech : Frank Breech / Extended breech. Incid...
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Other complication like acute cerebellar ataxia,meningitis ,encephalitis may cause REF:ANANTHANARYANAN TEXT BOOK OF MICROBIOLOGY 9EDITION PGNO.471
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Ans. C. Affinity and intrinsic activity with a + signa. Agonist: Drug having affinity and intrinsic activity (IA)/efficacyb. Antagonist: Drug having affinity but no intrinsic activityc. Inverse agonist: Having affinity and intrinsic activity which is opposite to that of agonist e.g. beta carbolines at BDZ receptord. Pa...
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D i.e. Musculocutaneous nerve
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Ans. is 'a' i.e., Rifampicin There are three main propeies of antitubercular drugs :- Bactericidal activity (tuberculocidal activity). Sterilizing activity. Ability to prevent resistance Bactericidal activity Isoniazid and rifampicin are the most powerful bactericidal drugs, active against all populations of TB bacilli...
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Early loss of primary canines is more common due to erupting permanent lateral incisors resorbing the roots of primary canines rather than caries. Early loss of primary canines leads to arch length deficiency by closure of space by the mesial movement of the posterior teeth or by lingual displacement of the anterior in...
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Ans. is 'b' i.e., TPHA is earliest to be (+) ye About other options - TPI is a specific treponemal test and gives definite diagnosis. - VDRL test becomes positive 7-10 days after the appearance of primary chancre (3-5 weeks after acquiring the infection.) - All treponemal and nontreponemal serological tests may be posi...
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Steroids
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Patau syndrome is due to trisomy 13.
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