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Autoantibodies in Systemic Lupus Erythematosus (SLE) Antibody Clinical Utility Antinuclear antibodies Best screening test/Most sensitive Anti-ds DNA Specific, correlate with disease activity, nephritis, vasculitis Anti-Sm Most Specific for SLE, marker for CNS lupus Anti-RNP Not specific for SLE Anti-Ro/La (SS-A) Sicca ...
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Surgery rarely required Congenital esotropia is the most common form of the esotropia. By definition esotropia that present before 6 month age, are designated as congenital esotropia. Salient features * More common is children with neurological disorder * Equal gender and racial distribution * Cross-Fixation, Nystagmus...
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Orotracheal intubation Patients with severe maxillofacial trauma and with low Sp02 even on oxygen suggests severe airway compromise or obstruction. In these cases emergency airway management is essential. The patient require immediate oxygen. - These patients needs to be intubated immediately. - But an impoant point to...
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Cryoglobulinemia associated with hepatitis C doesn't cause rise in unconjugated bilirubin, instead it is associated with conjugated variety of bilirubin. =Gall stones such as pigmentary stones are associated with hemolysis which increases unconjugated bilirubin =Spherocytes also cause hemolysis =Gout patients on treatm...
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Ans. (c) HematocolposRef.: Shaws 15th ed. 196-98* Hematocolpos is a medical condition in which the vagina fills with menstrual blood. It is often caused by the combination of menstruation with an imperforate hymen.* Hematometra: A related disorder is, where the uterus is filled with menstrual blood.* Pyometra: a type o...
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Submucus fibroid
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GERD is often associated with hiatus hernia type IClinical featuresInvestigationsClassical traid: reterosternal burning pain, epigastric pain and regurgitation.HeaburnsRegurgitationAbdominal painCoughDysphagia for solidsBelchingBloatingManometry for measuring LES tone24 hrs PH monitoringEsophagogram TreatmentLifestyle ...
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Ans. is a i.e. Lupus anticoagulant Anti Russel Viper Venom Antibody is the diagnostic test for antiphospholipid antibody syndrome, which is an impoant cause of recurrent aboion. Friends, Antiphospholipid antibody syndrome (APS) is an impoant and emerging topic for PGME exams. It is one of the least touched topic at und...
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Ans. is 'a' i.e. Neck Detailed study of the neck organs is required during autopsy of asphyxia death.Cranial thoracic and abdominal organs are removed before dissecting the neck, so that, the body is drained of blood.Such draining provides a clean bloodless field for the study of neck organs and prevents any artifactua...
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Lovset's method : The baby is lifted slightly to cause lateral flexion.The trunk is rotated through 180deg keeping the back anterior and maintaining a downward traction. This brings the posterior arm to emerge under the pubic arch which is then hooked out The trunk is then rotated in reverse direction keeping the back ...
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Ans. B. Chignona. Ventouse, also known as vacuum-assisted vaginal delivery or vacuum extraction (VE), is a method to assist delivery of a baby using a vacuum device. It is used in the second stage of labor if it has not progressed adequately. It may be an alternative to a forceps delivery and caesarean section. It cann...
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Large airway disease Bronchopulmonary dysplasia is clinically diagnosed in neonate <32 weeks of gestation who requires at least 28 days of oxygen therapy. It is now infrequent in infants> 1200 gm of bih weight & gestation >30 wks. Histology : * Airway epithelial hyperplasia * Squamous metaplasia * Alveolar wall thicken...
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Neuropraxia is due to compression of the nerve,the nerve conduction velocity is increased. It has good prognosis Ref:Guyton and Hall textbook of medical physiology 12th edition,page number:74,75,76
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Because HBcAg is intracellular and, when in the serum, sequestered within an HBsAg coat, naked core paicles do not circulate in serum and, therefore, HBcAg is not detectable routinely in the serum of patients with HBV infection. By contrast, anti-HBc is readily demonstrable in serum, beginning within the first 1-2 week...
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B i.e. Seraline The patients in questions are suffering from major depression and only antidepressant given in option is seraline. Alprazolam is anxiolytic; haloperidol and olanzapine are antipsychotics.
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Ans. is 'a' i.e., Osteosarcoma
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Factor Xa inhibitors * Oral Direct Factor Xa (Stua-Prower factor) Inhibitors are Rivaroxaban, Apixaban, Betrixaban and Edoxaban * Rivaroxaban inhibits free and clot associated Factor Xa AE reducing !rombin generation AE suppressing Platelet aggregation and Fibrin formation. * Other options: * Dabigatran etexilate is an...
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Ans. C. Isthmus* For female tubal sterilization, Isthmus is said to be the most common site. It is the part of the fallopian tube which is sealed or cut in a sterilization procedure or tubal ligation.* The mid isthmic portion of the tube is grasped in the bipolar electrocoagulation technique.Additionally, radiofrequenc...
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* The ECG shows a hea rate of 125 bpm with extreme axis detion. * P waves are absent with bizarre wide complex qRS in lead V4, V5, and V6 * Tall tented T waves which are seen with hyperkalemia, are present in all the leads. * The patient is a diabetic with deranged KFT. The patient is suffering from CKD and must be rea...
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Each milliliter of red cells contains 1 mg of elemental iron. Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 845
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PREVALENCE OF H.PYLORI: The prevalence of H. pylori varies throughout the world In developing world, 80% of the population are infected by the age of 20. In the United States this organism is rare in childhood. The overall prevalence of H. pylori in the United States is 30% The rate of infection with H. pylori in indus...
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Ans. is 'a' i.e., Community' development blocko ICDS was launched on 2nd October 1975 in 33 Community development block.o ICDS programme is a globally recognized community' based early child care programme, which addresses the basic interrelated needs of yound children, expectant and nursing mothers and adolescent girl...
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Ans. is 'c' i.e., Hypothyroidism.o Vit A deficiency causes oculor symptom.The different eye signs of vitamin A deficiency (VAD) in children, as graded by the WHO, are:# Night blindness (XN)# Conjunctival xerosis (XIA)# Bitot's spots (X1B)# Corneal xerosis (X2)# Corneal ulcer covering less than 1/3 of the cornea (X3A)# ...
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In Glanzmann thrombasthenia bleeding is due to defective platelet aaggregation,which is also transmitted as an autosomal recessive trait.Thrombasthenic platelets fail to aggregate toin response to ADP collagen epinephrine or thrombin due to deficiency or dysfunction of Gp 2b 3a. Bernard Soulier Syndrome due to deficien...
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Koenen tumors, or periungual and subungual fibromas, are a benign, cutaneous manifestation of tuberous sclerosis. They are disfiguring, painful, and challenging to treat as they frequently recur . Koenen's tumor is a cutaneous condition that results in fifty percent of tuberous sclerosis cases. Ref - Davidson 23rd edit...
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Complications Pouchitis( 7-33%) Small bowel obstruction( upto to 27%) Pelvic sepsis Anastomotic & pouch suture line leaks Pouch- vaginal fistula
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Increase in α feta protein is associated with hepatocellular carcinoma and chronic alcoholism is a well known and common predisposing factor. Clinical Feature In most cases, hepatocellular carcinoma presents as an ill defined upper abdominal pain, malaise, fatigue and weakness and sometimes awareness of an abdominal ...
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Pindolol is nonselec ve b-blocker with intrinsic sympathomimetic activity
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(Urate crystal) (22-A)Examination of svnovial fluidSuspected conditionAppearanceViscosityCellsCrystalsBiochemistryNormalClear yellowHighFew-As for plasmaSeptic arthritisPurulentLowWhite cells +++-Glucose lowTuberculous arthritisTurbidLowWhite cells +-Glucose lowRheumatoid arthritisCloudyLowWhite cells ++--GoutCloudyNor...
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Ans. is 'b' i.e., Stimulant purgatives Stimulant purgatives* They are powerful purgatives: often produce griping. They irritate intestinal mucosa and thus were thought to primarily stimulate motor activity.* Though some of them do directly increase motility by acting on myenteric plexuses, the more important mechanism ...
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The horizontal fissure of the right lung is a fissure separating the superior lobe from the middle lobe. It usually extends medially from the oblique fissure at the midaxillary line to the sternum, along the lower border of the fourth rib. The apex of the right lung reaches to a level above the clavicle and is therefor...
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Glycine is absorbed from uterine cavity and peritoneum and lead to fluid overload and electrolyte disturbances.
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Dermographism:-Type of physical uicaria- induced by mechanical stimulus also called as Skin writing Rapid appearence of wheal flare at the site of brisk firm stroke made with a firm object.Lesions are often linear/ assume the shape of eliciting stimulus.Local erythema followed by edema.Most common physical uicaria seen...
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B i.e. Granulosa Cell
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(Refer: DM Vasudevan, Textbook of Biochemistry, 7th edition, pg no: 266) Inhibitors of electro transport chain and Oxidative phosphorylation
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Signs and symptoms included in the syndromic approach of STD : Urethral discharge in males Vaginal discharge Lower abdominal pain in females Genital ulcer Scrotal swelling Inguinal bubo Ref: PARK&;S TEXTBOOK OF PREVENTIVE AND SOCIAL MEDICINE 23rd edition pg 333
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0.4 mg REF: Novak's gynecology 13th edition - page 85 "The Centers for Disease Control and Prevention has recommended that women of reproductive age who are capable of becoming pregnant take supplemental folic acid (0.4 mg daily) to help prevent neural tube defects in their infants"
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Ans. is 'a' i.e. Schistosomiasis Now here, is confusion in the question itself. There are two opinions among students (a) One group of students say that the question was small contracted bladder with calcified lesion in the kidney (b) Others opinion there is that the question was - small contracted bladder with calcifi...
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Ans. B: Lepromatous Tuberculoid (TT) - Can be either one large red patch with well-defined raised borders or a large hypopigmented asymmetrical spot - Lesions become dry and hairless - Loss of sensation may occur at site of some lesions - Tender, thickened nerves with subsequent loss of function are common - Spontaneou...
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Ans. A. Infant mortality, Life expectancy and Literacy. (Ref. Park's Textbook of PSM 22nd/pg.l6) INDEXKEY POINTS1Physical Quality of Life Index (PQLI) include# Infant mortality,# Literacy,# Life expectancy at age one.# The ultimate obj is to attain PQLI of 100.2Human Development Index (HDI) include# Longevity (Life exp...
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Ans. is 'c' i.e., Both Local infiltration is contraindicated near infection because it not only spreads the infection but is also ineffective, as the acidity produced by infection blocks the action of the drugs.
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Ref: Tuberculosis of the skeletal system by SM Tuli. page 70 - 81 Mercer's orthopaedic surgery fninth edition) by Duthie, Bentley and Dhal page 604Explanation:Radiological findings in TB hipThe earliest radiological sign on X-Rays is a slight loss of bone density (osteopenia) due to synovial edema.In some cases, becaus...
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Superantigens Activate large populations of T cells that express paicular subsets of the T cell receptor b protein, causing massive cytokine release and subsequent host reactions. Conventional antigens bind to MHC class I or II molecules in the groove of the ab heterodimer and bind to T cells the V regions of the TCR-a...
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ANSWER: (D) Allograft REF: Bailey and love 24Th ed p. 184 Allotransplantation (allo- from the Greek meaning "other ") is the transplantation of cells, tissues, or organs, to a recipient from a (genetically non-identical) donor of the same species.The transplant is called an allograft or allogeneic transplant or homogra...
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Neonatal hypothyroidism is a sensitive indicator of environmental iodine deficiency.This in turn indicates hypothyroidism. Parks textbook of preventive and social medicine.K Park. Edition 23.Pg no: 644
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A i.e. Retinoblastoma
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Abdominal aoa branches- - Gonadal aeries ( testicular aery) Superior supra renal aery is a branch of inferior phrenic aeries. All other branches of abdominal aoa are given in treasure attached.
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Prolactin increases tremendously in pregnancy and this ensures lactation.
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Calcineurin inhibitors (Specific T-cell inhibitors) Cyclosporine- It profoundly and selectively inhibits T lymphocyte proliferation, IL-2 and other cytokine production and response of inducer T cells to IL-l, without any effect on suppressor T-cells. Lymphocytes are arrested in G0 or G1 phase- used in various organ tra...
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Paratenic host or transport host remains alive without development or multiplication.
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- In liver there is absence of thiophorase, first enzyme of ketone body utilization pathway. - So Liver also cannot utilize ketone bodies. - Brain, muscle and hea can use ketone bodies during starvation. Extra information: In RBC, there is no mitochondria and ketone body utilization pathway takes place in mitochondria....
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Age < 24 years is a risk factor.
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Ans. is 'b' i.e., Hemangiomao Most common orbital tumor- Cavernous hemangioma.o Most common malignant orbital tumor- Lymphoma.IMPORTANT FACTSo Most common intraocular tumor in adults is metastasis. Metastasis is particularly common from carcinoma of breast and lung.o Most common primary intraocular tumor in adults is u...
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ECZEMA - Reaction pattern of inflammatory response of skin characterized clinically in Acute stage- Spongiosis( oozing out lesions) erythema vesiculation Chronic stages - Acanthosis (lichenified lesions) Histopathological features of eczema - Epidermis: 1 Acute phase spongiosis i.e. intercellular edema. 2 Subacute phas...
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Ans. d. Antigenic
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Ans. is d, i.e. McDonald stitichRef. JB Sharma p 121Patient presenting at 22 weeks with:Length of cervix 21 mm on ultrasound examination and history of second trimester abortions indicating cervical incompetence as the cause of preterm labor. In this case Mc Donald stitch will be the ideal treatment as it will prevent ...
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The fractured clavicle may damage the subclan vein, resulting in a pulmonary embolism; cause thrombosis of the subclan aery, resulting in embolism of the brachial aery; or damage the lower trunk of brachial plexus.
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In laryngomalacia direct laryngoscopy shows elongated epiglottis, curled upon itself (omega-shaped), floppy aryepiglottic folds and prominent arytenoids. Pediatric Epiglottis is omega-shaped and arytenoids relatively large covering significant poion of the posterior glottis.
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Ans. C. ADHDCauses of neuroregressionInheritedA. GreY matter involvement-With visceromegaly :- Niemann pick disease, Sandholf disease (GM2), sialidosis, Goucherdisease, Mucopolyschharidoses (MPS)Without visceromegaly :- TaySach Disease, Rett syndrome, Menke's kinky hair diseaseB. White matter involvement:-Leukodystroph...
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C i.e. Gamma amino butyric acidGn RH neurosecretion has been shown to be under the control of many neurotransmitter & neuropeptides:- GABA - exes an inhibitory action on GnRH secretion before onset of pubeyQ.- Glutamate - has an excitatory effectQ & whose levels increase at the onset of pubeyQ.Gama amino butyric acid (...
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Hypogonadotropic HypogonadismPituitary is making less LH & FSH ; therefore stimulation to the gonads i.e testes is lesser leading to hypogonadism. 1. LH | & FSH | 2. | Testosterone 3. Oligospermia 4. High prolactin levels
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Ans. is 'a' i.e. Acute Intermittent porphyria Barbiturates (Thiopentone) ppt acute intermittent porphyria
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The definition of 'Problem Village' as per the National Water Supply and Sanitation Programme is: Where no source of safe water is available within a distance of 1.6 km or Where water is available at a depth of more than 15 meters or Where water source has excess salinity, iron, flourides and other toxic elements or Wh...
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Ans. is 'b' i.e., Ranolazine o Ranolazine was initially assigned as paial fatty acid oxidation inhibitors. However, now it is believed that it acts by a different mechanism. It acts by blocking a late sodium current that facilitates calcium NCX (Sodium -Calcium exchanger) -4 Calcium overload and decrease left ventricul...
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Ans. More than 2 years
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• Daily replacement dose of thyroxine: 1.6 μg/Kg body weight (0.1-0.15 gm) . • For TSH suppression (in PTC and FTC), dose of thyroxine: 2.7 μg/Kg body weight.
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Ans. (b) 7th ribRef: Essentials of Anatomy IB singh 2nd ed. / 304
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There is no disturbance of consciousness in dementia. It is often irreversible. The hallucination can be present but are not common. Nootropics (or cognitive enhancers) have very limited role in the management of dementia.
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Direct microscopic examination of Indian ink-stained wet film of materials from lesions reveals capsulated budding yeast cells, the capsules are common in Indian ink preparation. Ref: Textbook of Microbiology, Ananthanarayan and Paniker; 9th edition
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Ans. is 'd' i.e., Somatostatin o There are following phases of gastric acid secretion : -The cephalic phase Just as salivary secretion may start before food enters the mouth, gastric secretion is also intitiated before food enters the stomach . Sight, smell or even thought of food stimulate gastric acid secretion. It i...
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Ans: C (Sodium hydroxide) Ref: Nelson's Textbook of Pediatrics, 19th editionExplanation:The Alkali Denaturation Test (Apt-Downey Test or Apt Test)Used to detect differentiate Fetal or neonatal blood from maternal blood (Qualitative).Clinical Uses:o Vaginal bleeding in late pregnancy is tested to rule out Vasa previa.o ...
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CONDUCTIVE HEARING LOSS AVERAGE HEARING LOSS SEEN IN DIFFERENT LESIONS OF CONDUCTIVE APPARATUS 1. Complete obstruction of ear canal: 30 dB 2. Perforation of tympanic membrane (It varies and is directly propoional to the size of perforation): 10-40 dB 3. Ossicular interruption with intact drum: 54 dB 4. Ossicular interr...
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Ans. Trotter and Gleser
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Pyometra refers to the collection of pus in the uterine cavity. For pyometra to occur there should be occlusion of the cervical canal, enough source of pus formation inside the uterine cavity and presence of low grade infection. Since none of these are present in a case of carcinoma of vulva, it is not associated with ...
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KD Tripathi essentials of medical pharmacology; edition7 ;pgs no-368 Dilute solutions or LA is infiltrated under the skin in the areas of operation-blocks sensory nerve endings.onset of action is almost immediate and duration is shoer than that after nerve block, e.g.lidocaine 30-60 min, bupivacaine 120-180 min. Infilt...
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Vestibular nerve nuclei lie at the pontomedullary junction. It arises from bipolar cells in the vestibular ganglion, ganglion of Scarpa, which is situated in the upper pa of the outer end of the internal auditory meatus. The vestibular nerve enters the brain stem at the pontomedullary junction and contains two division...
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Norepinephrine to Epinephrine conversion requires SAM (S-Adenosyl Methionine). Enzyme involved is Phenylethanolamine N-methyl transferase. Coisol is the activator. Synthesis of Catecholamines (Dopamine, NE and E) from Tyrosine. SAM (S - adenosyl methionine) is synthesized from dietary methionine with the help of enzyme...
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NSTIs (necrotizing soft tissue infections) can occur in any area of the body but are most commonly seen in the extremities, perineum, and genitalia, with fewer arising on the chest or the abdomen (extremities are more common) Fournier gangrene is a type of necrotizing fasciitis or gangrene affecting the perineum
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Ans. is 'd' i.e., Tetralogy of Fallot `Coeur en Sabot' refers to the radialogical appearance of hea in a patient with Tetralogy of Fallot. The cardiac silhouette resembles that of a 'boot' or Wooden shoe in 'Coeur en Sabot ' . X-rav findings in TOF Boot shaped hea (Coeur en sabot) Oligemic pulmonary fields Normal sized...
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Copper cements are basically modified zinc phosphate cements. Silver salts or copper oxide are sometimes added to the powders of the zinc phosphate cements to increase their ‘antibacterial’ properties. Copper cements gradually fell out of favor because of their poor biological properties. It was highly acidic and the c...
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Ans. B: It manifests just after bih Keratoconus is frequently due to a congenital weakness of the cornea, though it manifests itself after pubey. However it can occur secondarily following trauma or Down's syndrome. Keratoconus is divided into mild, moderate, and advanced. Mild keratoconus - External and corneal signs ...
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Ans: A
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Viruses can be cultivated in living systems only.
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Jumper's fractures of the sacrum are characterized by an H - or U - shaped fracture line in the upper sacrum, usually involving the S1-S2 region. Typical, the anterior segment of the pelvic ring is not injured. So, Jumper's fracture involve the posterior segment of pelvic ring.
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Ans. b. 4 weeks
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Free-water clearance (CH2O) is calculated as the difference between water excretion (urine flow rate) and osmolar clearance.Thus, the rate of free-water clearance represents the rate at which solute-free water is excreted by the kidneys. When free-water clearance is positive, excess water is being excreted by the kidne...
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Ans. is 'a' i.e., Arsenic Chronic arsenic exposure can cause 'black foot disease' a severe form of peripheral vascular disease, causing gangrene of lower limbs. Arsenic poisoning may be acute or chronic. Acute arsenic poisoning It can present in any of the two ways : Gastrointestinal type : It is the common form and re...
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The first poion of the axon is called the initial segment. The Initial segment in spinal motor neurons, the initial node of Ranvier in cutaneous sensory neurons is a site where propagated action potentials are generated.(Ref: Ganong's Review of Medical Physiology Twenty-Third Edition)
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Essential or indispensable amino acids: The amino acids which cannot be synthesized by the body and, therefore, need to be supplied through the diet are called essential amino acids. They are required for proper Growth and maintenance of the individual. The ten amino acids listed below are essential for humans (and als...
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Although a cross-sectional study provides information about disease prevalence it provide very little information of about the natural history of the disease or about the rate of occurrence of the disease (refer pg no:69 park 23 rd edition)
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Facial nerve supplies posterior belly of digastric muscle
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Ans. is 'c' i.e., Beta pleated, fibrillary, congophilic
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. Aoic wall contain smooth muscle cell matrix,elastin(in tunica media),collagen (in adventitia) as safe net in the wall to provide tensile strength prevent aneurysms formation.Elastin in tunica media is degraded and reduced significantly in infrarenal aoa in relation to collagen,abscence or less vasa vasorum in infrare...
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In a clinical study using the primer of the original Gluma adhesive system, an aqueous solution of 5% glutaraldehyde and 35% HEMA, currently marketed as Gluma Desensitizer; the desensitizing solution was applied to crown preparations. The authors concluded that Gluma primer reduced dentin sensitivity through a protein ...
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Ans. is 'a' i.e., Opioids Epidural opioid (fentanyl) analgesia is commonly employed as a therapeutic modality in the management of pain during labour.The general perception is that administered drugs remain in the maternal epidural space and do not compromise the respiratory status of the newborn.Contrary to the widely...
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Ans. (d) Staphylococcus AureusRef: Harrisons's 19 th ed.* Pulmonary pneumatoceles are thin-walled, air-filled cysts that develop within the lung parenchyma.* They can be single emphysematous lesions but are more, often multiple, thin-walled, air-filled, cystlike cavities.* Pneumatoceles are generally observed soon afte...
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Ans. (a) Affects Peyer's patches Enteric manifestations of S.typhi: S. typhi invades peyer's patches and form oval ulcer with their long axis along the length of bowel (Tuberculosis result in transverse ulcer). Peyer's patches lie along antimesentric border, so ulcer are common in antimesentric border. Stricture is rar...
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F..Gallwey scoring system is used to quantify degree of Hirsutism.
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Uterus begins to shrink in size 2 days following delivery and it becomes a pelvic organ after 2 weeks. By 6 weeks uterus regains its nonpregnant size. During involution of uterus there is no loss of myometrial cells. It occurs due to diminution of size of myometrial cells as a result of enzymatic autolysis of cytoplasm...
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Whipple's Disease (Intestinal Lipodystrophy) This is an uncommon bacterial disease involving not only the intestines but also various other systems such as central nervous system, hea, blood vessels, skin, joints, lungs, liver, spleen and kidneys. The disease is more common in males in 4th to 5th decades of life. Patie...
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