id stringlengths 30 30 | corpus stringclasses 3 values | sentence stringlengths 10 1.38k | token stringlengths 1 16 ⌀ | complexity float64 0 0.86 | difficulty stringclasses 5 values |
|---|---|---|---|---|---|
3PA41K45VN4U7YG4VFEGPOVYAIHP76 | biomed | While similarity-based genome annotation is a good initial method to identify genes and predict their function, in some cases it can be misleading, as genes of similar sequence can carry out different functions and be expressed in different tissues (for example, the sugar transporter gene family [7]). | family | 0.15 | very easy |
3SR6AEG6W5TL91EHZBWBTSD4SQGYHB | biomed | ADAM (A Disintegrin And Metalloprotease) is a family of membrane-spanning multi-domain proteins containing a metalloproteinase-like domain and a disintegrin-like domain. | family | 0.175 | very easy |
3UUSLRKAUL3LI1DEQ6NLPUE9WZ9D7B | biomed | TIF1β has been shown to act as a corepressor for the large family of Krüppel-associated box (KRAB) domain zinc-finger transcription factors (Friedman et al. 1996; Abrink et al. 2001). | family | 0.235294 | easy |
3TUOHPJXYHXE6MJWPEW9BHGI58ZWX3 | biomed | Reinforcement-mediated associative learning, or the ability to ascribe deterministic relationships between environmental stimuli that signal the probability of receiving a primary reinforcer (e.g. food), has been divided into 3 components or stages [1]. | relationships | 0.083333 | very easy |
3AJA9FLWSCYF558603M84J73MS5IFR | biomed | The adaptive significance of such a change, if any, is unknown, and it may simply be due to relaxation of selective pressure for night vision in this strictly diurnal species. | night | 0.089286 | very easy |
3LVTFB9DE5IY03SKOVXZV6Y1EHHQGW | biomed | A simple bud-like structure initiates the formation of many organs, including lungs, spinal cord, mammary glands, and hair follicles [1]. | lungs | 0.09375 | very easy |
3DZKABX2ZI5DOZ8W88VQB2CUXH4VCL | biomed | Total sterols and cholesterol in Dhcr7-/- embryonic lungs (as well as in brain and liver, data not shown) were reduced and 7DHC/8DHC elevated, but a significant amount of cholesterol was detectable, comprising ~60% and ~30% of total tissue sterols at E13.5 and neonate, respectively. | lungs | 0.214286 | easy |
3R6RZGK0XFCQR29140DF8T4D05LYVV | biomed | By this stage, cholesterol levels were already lower and its immediate precursor, 7-DHC, elevated in the lungs (this study) as well as in the whole body [16,17]. | lungs | 0.233333 | easy |
3BDORL6HKKDLVSRFZOQGA5NRCBWRCT | biomed | Loss or damage to articular cartilage is a hallmark of arthritic diseases and is one of the most common reasons that both young and old adults seek medical care. | damage | 0.09375 | very easy |
3PUOXASB573SZL63XLA2UIOIF7CZ9D | biomed | However, the development of safe and effective secretase inhibitors will ultimately be required to determine whether the human brain has the capacity to repair amyloid-associated damage of AD once the progression of pathology is arrested. | damage | 0.133333 | very easy |
3Y7LTZE0YTMQJDU6VW5TQEBWSSMZU4 | biomed | Several proteins that interact with RAD51 are thought to 'mediate' assembly of RAD51 at sites of DNA damage (reviewed in [30]). | damage | 0.178571 | very easy |
35JDMRECC499302FF42Z1P9NVEYEGD | biomed | In addition to meiosis-specific proteins, these include factors that play roles in DNA damage signaling in mitotic cells [6–10]. | damage | 0.192308 | very easy |
3FI30CQHVKJ9Z41PT0RNOQQDY3DB63 | biomed | For example, a QTL for PROP avoidance has been suggested on chromosome 7 [16], and we observe a suggestive QTL for quinine taste on chromosome 8 (Figure 2); in neither case are Tas2rs found at these loci (data not shown). | avoidance | 0.09375 | very easy |
3VIVIU06FKCLBF0NMQQLZ9RCJTHIMY | biomed | We present a strategy to search candidate genes for small-effect QTL. | candidate | 0.09375 | very easy |
3LXX8KJXPW9G0HSWVCZLEKHEV349OG | biomed | Twenty-one genes were identified as potential candidate genes for six of the eight small-effect QTL according to their gene expression patterns during CIA and their genomic locations. | candidate | 0.183333 | very easy |
3DZKABX2ZI5DOZ8W88VQB2CUXI1VCK | biomed | To identify the small-effect QTL of CIA as well as the potential candidate genes inside them, we investigated CIA genetically susceptible and resistant strains at both the genome and transcriptome levels. | candidate | 0.25 | easy |
3P888QFVX3UMSG9ICEA70F7353DQOO | biomed | Therefore, we have presented a strategy to identify small-effect QTL and search for potential candidate genes within them. | candidate | 0.25 | easy |
372AGES0I459YQ2AQKM3OI81DTKRXV | biomed | Our olfactory receptor EST collection provides 5' untranslated region (UTR) sequences for many genes and, therefore, a large dataset of candidate promoter regions. | candidate | 0.293478 | easy |
31J7RYECZLQQ5RM4E7407XV12MB1LI | biomed | Notably, A. thaliana does not appear to have a meiotic checkpoint activity that eliminates mutant meiocytes in a manner analogous to organisms such as mice, budding yeast, and female Drosophila [11,57], and mammalian TRIP13 is more similar to Arabidopsis PCH2 than the fly or worm proteins (Figures 1A and S1). | fly | 0.1 | very easy |
38VTL6WC4AD9T8UMY9V24VAENHK5YW | biomed | With the completion of the genome sequencing projects of human, mouse, rat, fruit fly and nematodes, we are now in a position to ask fundamental questions in regard to how genes interact in the context of the whole organism. | fly | 0.1 | very easy |
3UAU495MIISEK9GZTNUCAG4S8OJUOX | biomed | At 54 wk, these cells in the alphaA/BKO lenses were larger in cross sectional diameter than wild type, and exhibited a much greater variation in the cross sectional size and cell shape. | shape | 0.1 | very easy |
35NNO802AVWRTXLNYR5LCOGCOJMNIY | biomed | The lack of cellar organization and uniform cell shape at the equatorial region observed in alphaA/BKO lenses supports this hypothesis. | shape | 0.15 | very easy |
3T2EL38U0MK9MPNAD5X3JSYWH7IXQ0 | biomed | Ca2+ also induces a transbilayer phospholipid redistribution inducing a shape change of red blood cells [51]. | shape | 0.183333 | very easy |
39WICJI5ATS6KJHNGC9S35LWFFX3ZV | biomed | The addition of exogenous alpha-crystallin to primary bovine lens epithelium was shown to induce rapid changes in cell shape, leading to the formation of lentoid bodies [21]. | shape | 0.294118 | easy |
3ZRKL6Z1E83ADJ7XGZM4Q6D2W52GSB | biomed | The reasons for the interesting differences between the two PGC-1α-deficient mouse lines are not clear. | reasons | 0.1 | very easy |
3X55NP42EOGC6FFHT3BQC7JI5GVP31 | biomed | Such studies are very difficult/impossible to do in human patients for obvious ethical reasons, and often must rely on autopsy tissue. | reasons | 0.152778 | very easy |
3IKMEYR0LWVMA6MICBSDXGSR5TI2KX | biomed | These qualitiesalso make human ES cells attractive sources for cell transplantation therapy to treat various diseases, including spinal cord injuries and juvenile diabetes. | therapy | 0.1 | very easy |
3MA5N0ATTCB8MMKPQVHKLN8G90DKWX | biomed | Long-term treatments would certainly be possible and could be a key to effective therapy. | therapy | 0.178571 | very easy |
3T6EIBTM9LO53W80DZ839K8TC4IAAX | biomed | One aim of using animal models for complex diseases is to detect the genetic basis of these diseases. | aim | 0.25 | easy |
3WGCNLZJKF877FYC1Q6COKNWTD91D2 | biomed | The Src tyrosine kinase was shown to play a role in bone remodeling when Src-/- mice died at 6 months of age with an osteopetrotic phenotype [48] and the defect was attributed to defective osteoclast function [55-59]. | months | 0.1 | very easy |
36QZ6V1589DTI18S04BLULET5DHSUN | biomed | The expression profiles of wild-type and Nrl KO retinas at P2, P10 and 2 months were analyzed and mr-s was not included in 161 differentially expressed genes in the Nrl KO retina. | months | 0.328125 | easy |
341YLJU21IZV4BWUC871K0DEDPT2IM | biomed | The involvement of target-derived signals in induction of ETS transcription factor expression raises the question of the necessity for the observed delay in the onset of ETS signaling for neuronal maturation. | delay | 0.1 | very easy |
3JU8CV4BRLC1S483C1VI0AHT07MPOR | biomed | Higher pro-myelinating Schwann cell density and marked delay in myelin formation indicate that ADAM22 plays an important role in Schwann cell differentiation, but not in proliferation. | delay | 0.216667 | easy |
3YLPJ8OXX8D2XK0CF8QQGPXRLFUX4C | biomed | It is less clear whether loss of Fog2 results in a global branching defect, as Fog2 lungs appear to have a slight developmental delay, which could result from many causes. | delay | 0.25 | easy |
3DWNFENNE3V120VNY4BPPGPCAHGJ4B | biomed | These observations argue that membrane trafficking defects do not result from excessive subunit c accumulation compromising the lysosome, but rather are early events in the disease process preceding subunit c accumulation. | events | 0.1 | very easy |
3BVS8WK9Q0VPSOWQV10CLTGI7UDBI2 | biomed | The differentiation of sensory neurons of dorsal root ganglia (DRG) has been studied extensively with respect to inductive events that specify neuronal fate [2,3], as well as the involvement of late target-derived neurotrophic factors in the control of neuronal survival [4]. | events | 0.214286 | easy |
30U1YOGZGAW71ZX6E9LWKLA5JEKDSY | biomed | Interestingly, this phenotype was only evident during a rather narrow window of postnatal life. | window | 0.1 | very easy |
388CL5C1RJN1927IGW7LZKB8JC5LH1 | biomed | The nature of the synapsis checkpoint in male mice remains unidentified. | nature | 0.1 | very easy |
3SBNLSTU6U542BJK91F4GE786SLZDO | biomed | While our knowledge of the assembly and nature of recombination machinery is extensive, little is known about the disassembly of recombination intermediates, recruitment of DNA replication machinery during recombinational repair, and how the choice between different repair pathways is made. | nature | 0.203125 | easy |
3DGDV62G7O9NLXJYP3XLTXEQZ2Q2PY | biomed | Given the elaborate nature of the RAD51–BRCA2 interaction, it seems somewhat unlikely that the only role of BRCA2 in promoting recombination is to serve as a specific nuclear transporter of RAD51. | nature | 0.264706 | easy |
3L55D8AUFAXUST31DJIAI1GOFZ3YCW | biomed | The overlapping nature of our MMU2 strains allowed us to parse the chromosome into five regions (Regions I–V) (Figure 2). | nature | 0.362069 | easy |
3RQVKZ7ZRKJYFRFYTH34TBN5Z8Q722 | biomed | We assume that ADAM22 partially modulates integrin-mediated signals or is involved at a later stage of myelin formation. | stage | 0.1 | very easy |
3APP19WN71E5QL909MJ1P1HAEH3G6P | biomed | As all prior reported manipulations of the BMP pathway during skeletal development either result in a block at the first stage of chondrogenesis or allow complete skeletal formation, this is the first demonstration of a requirement for BMP activity in osteogenic differentiation. | stage | 0.153846 | very easy |
3VDVA3ILIDFAJZ833G7KU5QT65V1GI | biomed | They represent only 10% of E4 embryos obtained from Chaf1a+/− mice intercrosses, suggesting that more than half of the homozygous mutant embryos had degenerated before this stage. | stage | 0.216667 | easy |
3RHLQY6EDT4OZEVVO8PEMIUZ5XJD4R | biomed | An independently derived Capn4 knockout, involving a more extensive deletion of the gene, resulted in an earlier embryonic lethality, apparently at a pre-implantation stage [32]. | stage | 0.25 | easy |
3UXQ63NLAAMRIP4WG4XPD98AOZ0LBL | biomed | In many organisms, including S. cerevisiae, Drosophila melanogaster, C. elegans, and mice [1–4], meiocytes with defects in recombination and/or chromosome synapsis trigger meiotic arrest in the pachytene stage of meiotic prophase I. | stage | 0.34375 | easy |
3LAZVA75NIR50X7XA3K64X90PYS2OH | biomed | The interaction of olfactory (or odorant) receptors with their odorant ligands is the first step in a signal transduction pathway that results in the perception of smell. | perception | 0.1 | very easy |
3R5OYNIC2C9H5WDB8IHHUKNGZF3TPH | biomed | Prior to the 1990's, alpha-crystallin was thought to be a structural protein whose major cellular function was to produce a dense solution necessary for the refraction of light in the lens. | light | 0.1 | very easy |
3VDI8GSXAFTSUZSO21GZ9FD1KBV8G3 | biomed | In light of these newer findings, our intermediate MSUD mouse provides a model to test the effect of thiamin with respect to BCKDH activity and blood amino acid levels at the level of the whole animal. | light | 0.125 | very easy |
3DZKABX2ZI5DOZ8W88VQB2CUXH9VCQ | biomed | With the normal time of eye opening at approximately 14 days after birth, the 5 wk old mice had their eyes open and lenses exposed to light for only about 3 weeks prior to morphological analysis. | light | 0.133333 | very easy |
32LAQ1JNT9PUX1L7P4GB4QAF7XTTUD | biomed | In light of the observation that the Wnt4 −/− XX gonad does not increase significantly in size ( Figure 6), it is possible that the FGF9/SOX9-expressing population did not reach a critical threshold. | light | 0.205882 | easy |
3AFT28WXLF29BILZZ65YRDGHETRIO8 | biomed | One striking observation of this study is that precocious induction of ETS signaling promotes neuronal survival without a requirement for neurotrophic support and in complete absence of Trk receptor expression. | support | 0.214286 | easy |
3G9UA71JVVUYLND6029WSS9M1JC7JP | biomed | In support of this, AQP2-F204V can interact with wild-type AQP2 (Figure 5B), and when coexpressed with wild-type protein, AQP2-F204V can reach the cell surface (Figure 5C bottom right panel and 5D). | support | 0.220588 | easy |
3G5RUKN2EC3YIWSKUXZ8ZVH95T59N7 | biomed | Two dox-treated groups were compared to two untreated groups: one group of mice was born and raised on dox, a second group was treated with dox for 2 wk starting at 1 mo of age (4 wk + 2 wk dox); two untreated groups kept on normal chow were harvested at either 4 or 6 wk of age. | mice | 0.1 | very easy |
3HXCEECSQMT70MEB5X2ITZH9OGXZY2 | biomed | Embryonic stem (ES) cells were first derived from the blastocysts of mice in 1981 [1,2] and humans in 1998 [3]. | mice | 0.125 | very easy |
35ZRNT9RUIYULF3GE3YBN7ESVB03OZ | biomed | Compared to the levels in untreated 4-wk-old mice, PBS-soluble Aβ42 dropped by 95.2% following 2 wk of dox treatment and by 99.2% with chronic treatment (Figure 2A). | mice | 0.15625 | very easy |
3SBX2M1TKDNIONZ0TUVYMH1YOC8Q49 | biomed | Consistent with this hypothesis, strong activation of microglia through transgenic expression of TGFβ [58] or central injection of lipopolysaccharide [59,60] can by itself substantially reduce plaque burden in APP transgenic mice. | mice | 0.203125 | easy |
31GN6YMHLPS6A5XXV4QMC9ZQQTRWSP | biomed | Single transgenic mice up to 15 mo of age showed no sign of pathology (Figure S3). | mice | 0.216667 | easy |
3C8QQOM6JP115XI2MEP6ZWCNJPKLIU | biomed | All of these findings raise many questions as to the possible role(s) of alpha-crystallin in the nucleus and in cell cycle regulation during differentiation. | questions | 0.223684 | easy |
368IUKXGA58B3Y2ZC59OJAV2F8Q6PJ | biomed | The observation of unequal expression leads to a number of questions. | questions | 0.235294 | easy |
3GMLHYZ0LEXQENK1ZA3AC72UMYDUY3 | biomed | Supplementary data are available at NAR online. | online | 0.107143 | very easy |
3KI0JD2ZU1IMXSYZGJF7JO4HFDN67D | biomed | In lens epithelium derived from alphaAKO lenses, cell growth rates were reported to be 50% lower compared to wild type [31], suggesting a role for alphaA in regulating the cell cycle. | growth | 0.107143 | very easy |
3J94SKDEKIP6VXZV2D8ORA0D5TJD51 | biomed | The 2P unique region (Region I) contains an hg modifier with large effects on growth and smaller effects on obesity (Table 3). | growth | 0.232143 | easy |
3V7ICJJAZAGVKHXBACY8RS6Z2CD4BH | biomed | Our results support and refine the hypothesis, indicating that huntingtin is required for proper mesoderm patterning and for normal regional restriction of the expression of a subset of growth and transcription factors. | growth | 0.234375 | easy |
371Q3BEXDH9A40226RATBDT87V1SZH | biomed | Complex traits, such as polygenic growth and obesity are influenced by the small to moderate direct effects of quantitative trait loci (QTL), epistasis between QTL alleles, environmental perturbations and QTL-environment interactions. | growth | 0.336957 | easy |
3WUVMVA7OB3644G8PRO2QDZ2LPUAZ3 | biomed | Through this process, it is also possible that deficits in RanBP2 cause a disturbance in the equilibrium between Cox11, HK1, and RanBP2 by leading to an increase of the inhibitory activity of Cox11 over HKI that promotes the uncoupling of the interaction of HKI from RanBP2, ultimately causing HKI degradation. | increase | 0.109375 | very easy |
3P520RYKCH6SCZAHO8YD1A41RTE5U3 | biomed | Third, we found evidence for an age-related increase in body fat in PGC-1α−/− mice (females earlier than males), whereas Lin et al. identified a male-specific resistance to diet-induced obesity and insulin resistance. | increase | 0.173077 | very easy |
3TCFMTM8HEOK450W41MVS1WSWMK21U | biomed | Therefore, it appears that growth retardation caused by cholesterol deficiency was primarily because of an inhibition of cell growth and proliferation, rather than an increase in cell death. | increase | 0.191176 | very easy |
3909MD9T2ZH3P06K4KWHJ49BUZYFEF | biomed | Extraembryonic development in Hdhex4/5/Hdhex4/5 embryos is associated with mildly elevated levels expression of Hnf4 in the primitive endoderm and Pem in the lopsided anterior chorion but the expression of other known signals, such as Bmp4 from the extraembryonic ectoderm, and Dkk1 and Lefty1 from the AVE, appear to be normal, although the slight increase in Dkk-1 expression in Hdhex4/5/Hdhex4/5 embryos suggests that further investigation into Wnt signaling is warranted. | increase | 0.319444 | easy |
35F6NGNVM8JSZQ9BCWN0UYWVZLXT7A | biomed | Consistent with this idea, genetic analysis of a number of meiotic regulatory genes in the mouse has demonstrated a much stronger requirement in males than in females [1,4]. | idea | 0.109375 | very easy |
335VBRURDJ0UOQF71YWP98N0R13E9M | biomed | Further support for this idea has been provided by recent work in our lab showing widespread derepression of cone genes in the Notch1−/− retina (unpublished data). | idea | 0.125 | very easy |
3JMNNNO3B14D56GZ1PBGLRMMSZYW2S | biomed | These findings support the idea that FGF9 acts as the antagonist of Wnt4. | idea | 0.180556 | very easy |
3Q7TKIAPOTAKXM2GU0OV8ZWARJJLDX | biomed | Recent experiments addressing the temporal constraints of transcription factor action in proliferating neural progenitor cells adds to the idea that defined temporal windows, during which transcription factors act to control distinct downstream target genes, are of key importance to neuronal fate acquisition. | idea | 0.214286 | easy |
3Y3CZJSZ9KT0W7I0KE38WZHHKUA5RZ | biomed | NT-3 is expressed in the ventral spinal cord, in the developing limb buds, and in intrafusal bag fibers of muscle spindles later in development (Copray and Brouwer 1994; Fariñas et al. 1996; Tojo et al. 1996). | muscle | 0.109375 | very easy |
3EPG8DX9LKQFKU2L7MZJR4H2JCHP5M | biomed | In addition to their expression in brain, both Annexin A7 isoforms have only been described in heart muscle and red blood cells [5-8]. | muscle | 0.236111 | easy |
3GS542CVJVNUS7MEQX3M5EHNE8Z597 | biomed | Is NT-3 only a chemotrophic survival factor for muscle sensory afferents, or does it have additional roles in the development of the proprioceptors and the establishment of the monosynaptic reflex arc? | muscle | 0.25 | easy |
34O39PNDK682LNZ9LOULZLH9UQWBR6 | biomed | Second, mitochondrial respiratory capacity is modestly but significantly altered in skeletal muscle and liver of PGC-1α−/− mice. | muscle | 0.283333 | easy |
3UEBBGULPFOKEW36UKBMNMVEGNNFUR | biomed | PGC-1α is enriched in brown adipose tissue (BAT), heart, slow-twitch skeletal muscle, and kidney—all tissues with high-capacity mitochondrial systems. | muscle | 0.352941 | easy |
3CIS7GGG65JS8I3AZ9RG54AE4N6UEO | biomed | In one study, 12 distinct measures of Wnt signaling in Pygo mutants were performed, including analysis of leg, wing, and eye imaginal discs. | measures | 0.359375 | easy |
3ZZAYRN1I6RZKW1ATI425KIQPACTO5 | biomed | The defects that present in the pre- or perinatal period include Bochdalek hernia, diaphragmatic aplasia, and various degrees of muscularization defects or eventrations. | period | 0.111111 | very easy |
3X7837UUADYFHNZ1HS44ME9Q68RJ61 | biomed | Polymerization of the SAM domain has been previously reported to be essential for the repressive functions of ph and TEL [43,44]. | functions | 0.111111 | very easy |
3AA88CN98P3CBRFP5WZ86KTWK7FKYW | biomed | Type IIb fibers have the lowest levels of mitochondrial content and oxidative enzymes, rely on glycolytic metabolism as a major energy source, and are susceptible to fatigue, while the oxidative and contraction functions of type IIa and IIx lie between type I and IIb (Booth and Thomason 1991; Berchtold et al. 2000; Olson and Williams 2000). | functions | 0.214286 | easy |
3JY0Q5X05J67NEY6LZSN1SUZ8V6GGR | biomed | As alluded to earlier, a complicating problem for studying potential meiotic checkpoint genes in mice is that as in yeast, such genes often have mitotic functions (such as RAD24 [7]), and their ablation can cause lethality [42]. | functions | 0.25 | easy |
3T2EL38U0MK9MPNAD5X3JSYWH7DQXO | biomed | Our genetically modified mouse strain has the potential to be a useful and sensitive tools for detailed investigation of ADAM proteins' functions in the nervous system. | functions | 0.272727 | easy |
37MQ8Z1JQEWHUBBZGQT46O7237YY2T | biomed | Clot formation and lysis, which ultimately determine thrombosis, requires platelet aggregation, coagulation, and fibrinolytic functions. | functions | 0.279412 | easy |
3LN50BUKPVBTMJ56Z9FQ8TDZ52HLP6 | biomed | Further, we observed an apparent loss of tissue masses in areas that are normally occupied primarily by type I and II fibrocytes. | loss | 0.111111 | very easy |
3R5OYNIC2C9H5WDB8IHHUKNGZF3PTD | biomed | In one study using CF mice on different genetic backgrounds, a region on mouse chromosome 7 was shown to ameliorate intestinal blockage and the effect was in part due to a calcium-regulated Cl-channel which compensated for loss of CFTR function [16,17]. | loss | 0.222222 | easy |
3MVY4USGB6NO9ADS6NM7BIQIBJRSIE | biomed | It is interesting that the SOX9 transcription factor continues to be expressed in mutant cartilage despite loss of Col2a1, a direct target of this transcription factor (Bell et al. 1997; Lefebvre et al. 1997). | loss | 0.25 | easy |
3UZUVSO3P7V9VAY1Q70UEUTKR0AMET | biomed | Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells. | loss | 0.266667 | easy |
3J5XXLQDHMBPBZCDFFKPIZ80R5OV3M | biomed | The loss of GLD-1 protein in Caenorhabditis elegans prevents the appearance of stem cells [35], and the absence of the KH domain protein HOW in Drosophila prevents muscle differentiation and results in flies with held-out-wings [36,37]. | loss | 0.296875 | easy |
3GITHABACYLNIC7L9OKTP89VZNV2N8 | biomed | We took several precautions to reduce the probability of this occurrence. | probability | 0.111111 | very easy |
3MDKGGG61QN9VQV6TMI8OKWZ4ADT6B | biomed | In agreement with this, when we carried out a selective comparison between the (129 × C57BL/6)F2.Apcs-/- mice and Chromosome 1 genetically matched controls, we failed to detect any significant difference in the levels of these two auto-Abs. | comparison | 0.111111 | very easy |
3CIS7GGG65JS8I3AZ9RG54AE4MDUET | biomed | In humans, genetic diseases of the eye are common and the primary site of disease is most frequently photoreceptors (for review see [1-3]). | site | 0.111111 | very easy |
3WPCIUYH1A88GZAL39QMUQ6RLW0DTN | biomed | In a third model, there would be a limiting quantity of transcription factors - the cell might contain a single transcriptional 'machine' that is capable of accommodating the promoter of only one olfactory receptor gene, similar to the expression site body used by African trypanosomes to ensure singular expression of only one set of variant surface glycoprotein genes [22]. | site | 0.1875 | very easy |
3EKZL9T8Y8M86YDC3JEMW1LLP2YHCM | biomed | One possibility is that CEBPG and each of the correlated antioxidant or DNA repair genes is regulated by a transcription factor that is as yet undiscovered, and/or has a recognition site that is not yet known and was not in the Genomatix software database. | site | 0.233333 | easy |
3DQYSJDTYLBKPMX54E23PB9IY5NEX0 | biomed | We therefore focused on the XY body, the most prominent site of DMRT7 accumulation. | site | 0.25 | easy |
3FW4EL5A3LORTQISN5M9XK6XOS422H | biomed | The availability of homozygous animals demonstrated that both reporter gene expression and the site of transgene integration were developmentally neutral. | site | 0.293478 | easy |
33TGB4G0LPHME5F2U9RYOX9J1ECTX5 | biomed | The structural Gh gene itself and Stat5b are excellent candidates. | candidates | 0.111111 | very easy |
30QQTY5GMKK7Z3O0C1DAZUIXIZ47UF | biomed | Maternal genotype effects on growth and obesity have been observed in a number of mouse crosses [8,32-35] and their existence in the current cross cannot be discounted. | number | 0.15625 | very easy |
3SA4EMRVJV2GPNGKAGT7A9LB24C0PI | biomed | In each case, the autoimmune phenotype was described in mice in which the null mutation was generated in 129 embryonic stem cells and then backcrossed to the C57BL/6 or another genetic background. | background | 0.115385 | very easy |
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