id stringlengths 30 30 | corpus stringclasses 3
values | sentence stringlengths 10 1.38k | token stringlengths 1 16 ⌀ | complexity float64 0 0.86 | difficulty stringclasses 5
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|---|---|---|---|---|---|
32W3UF2EZOLEUMPHOCU32CCHKX7C4Q | biomed | Despite the importance of articular cartilage in joint health and mobility, little is known about the factors that create and maintain it in thin layers at the ends of long bones. | health | 0.142857 | very easy |
3M47JKRKCX1QX63IQO7DXO0CQXS68Z | biomed | Histopathological analysis revealed marked hypomyelination in the sciatic and trigeminal nerves. | analysis | 0.132353 | very easy |
33J5JKFMK6YX6RGWTGQFCC9SADA3Q1 | biomed | Sequence analysis failed to show any coding alterations segregating with disease or any alterations that were inconsistent with Mendelian patterns of inheritance within the family. | analysis | 0.175 | very easy |
3HXCEECSQMT70MEB5X2ITZH9OGRZYW | biomed | HO, KO and BMD contributed their experience gained from studies of serine-carboxyl peptidases and the design of their inhibitors, aimed at analysis of substrate-enzyme interactions and enzyme specificity. | analysis | 0.220588 | easy |
336OE47KI2KM2XE1PZVRNWJXPXLWVU | biomed | SAK performed the statistical analysis for interpretation of data. | analysis | 0.222222 | easy |
302U8RURJZ1WF35NXY44RD66WLINVV | biomed | SLC co-conceived of the study, participated in establishment and phenotypic analysis of cell lines, and drafted the manuscript. | analysis | 0.328947 | easy |
3DW3BNF1GHIBCWIJRWFL9GGB7RGV8E | biomed | None declared | null | 0.132353 | very easy |
3H6W48L9F4P9XDH53NMSH4UF39QPW8 | biomed | None of these morphological differences have been reported in the single alphaA or alphaB knockout mice. | null | 0.133333 | very easy |
3M0556243SK7J6JXXJZ09R3K8RUNF7 | biomed | None of the annexins contains a typical nuclear localization signal and their mechanism of nuclear import remains to be elucidated. | null | 0.1875 | very easy |
3IKDQS3DQE082TOW91W7WDM0PF8ICB | biomed | None declared. | null | 0.203125 | easy |
3OID399FXG7YXUSK8PLXDMRQUNSDFF | biomed | This mouse model of NDI based on an Aqp2 allele that can be rescued provides the opportunity to test therapies, including gene therapy, that may promote proper subcellular localization. | opportunity | 0.133333 | very easy |
3NQUW096N688UWPZIKJTM3DK0YZL9B | biomed | In two such cases, the transcript would encode a functional olfactory receptor, with the initiating methionine and first few amino acids encoded by an upstream exon, as has been observed previously for a subtelomeric human olfactory receptor gene [25]. | cases | 0.276316 | easy |
3S829FDFT21FXGJ58JRJJTRXYSTXDV | biomed | In the present paper we have analyzed female mice that previously had undergone a reproductive study (Liljander M, Sällström MA, Andersson S, Wernhoff P, Andersson Å, Holmdahl R, Mattsson R, unpublished data). | paper | 0.133333 | very easy |
32K26U12DNONTREA84Q1V8UCIHGDV3 | biomed | ELK and SBP wrote the paper. | paper | 0.1875 | very easy |
36MUZ9VAE626RGSODE1RV46QIMDDEX | biomed | In this paper we have determined that the primary role of the rod-specific transcription factor, Nr2e3, is to maintain cone genes transcriptionally silent within rods. | paper | 0.194444 | very easy |
36MUZ9VAE626RGSODE1RV46QIMDEDY | biomed | SP designed and did most of the work for targeting the Pygo genes, provided oversight for the project and helped write the paper. | paper | 0.220588 | easy |
3HA5ODM5KASTVGXS5ULQQ7GCJKVVSK | biomed | The first conclusion from the present paper is that multiparity does not negatively influence the incidence or severity of CIA induced later in life (Table 2). | paper | 0.220588 | easy |
3L7SUC0TTUUA4KJ7I01FT5RGXZVM02 | biomed | These findings suggest that mr-s functions as a member of a transcriptional repressor complex in retinal photoreceptor development. | member | 0.133333 | very easy |
34D9ZRXCYRU93SUUUZUUUK2ZYAPAST | biomed | Positional cloning identifies the mon gene as the zebrafish ortholog of mammalian transcriptional intermediary factor 1γ (TIF1γ), a member of the TIF1 family of transcriptional coactivators and corepressors (Le Douarin et al. 1995; Friedman et al. 1996; Kim et al. 1996; Venturini et al. 1999; Peng et al. 2002). | member | 0.153846 | very easy |
3Q9SPIIRWJM2A9B3E44VR95K4NLAW8 | biomed | HOMER3 is a member of the HOMER family of proteins that are constitutively expressed in the brain and play a role in post-synaptic signalling and receptor trafficking by forming multivalent links with various receptors and PSD scaffolding proteins [35,39-41]. | member | 0.2 | easy |
3HY86PZXPYICZLCCXLHWU25HTQ8E18 | biomed | Crx, cone-rod homeobox; Otx2, orthodenticle-related homeobox 2; TRβ2, thyroid hormone receptor beta 2; Nrl, neural retina leucine zipper; Nr2e3, nuclear receptor subfamily 2 group E member 3; EST, expressed sequence tag; EphB2, ephrin receptor B2; EphA4, ephrin receptor A4; TEL, translocation ETS leukemia. | member | 0.328947 | easy |
3YO4AH2FPDK1PZHZAT8WAEBL71Q0Q3 | biomed | In addition, MTF-1 appears to repress the expression of solute carrier family 39, member 10 gene (Slc39a10), which encodes a putative metal ion transporter. | member | 0.441667 | neutral |
3XABXM4AJ15J7OM25XLB3TH3QY98Q3 | biomed | This QTL maps to the same chromosomal position as a previously identified QTL for quinine intake, Qui [16,28], indicating that taste is the major factor in regulating quinine aversion. | taste | 0.133333 | very easy |
3Y3N5A7N4G971FFSQ8COLXL09CAMY3 | biomed | Second, these previous attempts to map bitter taste QTLs relied on behavioral assays that measured consumption, and were thus susceptible to contributions of post-ingestive effects such as toxicity. | taste | 0.153846 | very easy |
3VGZ74AYTGGU62I1JDW4B19KA3EGCH | biomed | The genes that encode T2Rs, the Tas2rs, were first identified by database mining of mammalian genomes near chromosomal markers previously linked to differences in bitter taste sensitivity [9,11-18]. | taste | 0.203125 | easy |
3XQ4XW3OD9CKYPZQHK1FO2J1MM32SK | biomed | This is an important distinction, as the consumption of bitter-tasting stimuli can be dependent on factors independent of taste, such as toxicity [29]. | taste | 0.25 | easy |
37PGLWGSJT6QLR0K1ED5KWZ8UOHIKO | biomed | Using 17 BXD lines that were genotyped at 762 informative chromosomal markers, we mapped a major QTL for QHCl taste to a ~5 Mb interval on distal chromosome 6 that contains all 24 of the Tas2r genes in the distal cluster. | taste | 0.283333 | easy |
3X2YVV51PU46GLY3ILB2G8CH0TL1WH | biomed | ADAM11-deficient mice survived more than one year without ataxia or tremor, showed no abnormalities in body weight gain, spontaneous motor activity, muscle strength, or walking patterns, and exhibited no apparent anatomical-histological changes. | changes | 0.160714 | very easy |
32TZXEA1OLKU7JFJ8F5JLGTQG0G41S | biomed | Furthermore, disruption of ATRX leads to diverse changes in DNA methylation [11]. | changes | 0.192308 | very easy |
33IXYHIZB5IJO6U8GPHAZLFMLVU2EJ | biomed | Comparison of the expression of the HPLAP marker (driven directly by Gdf5 control elements) and the R26R LACZ marker (expressed following Gdf5-Cre recombination) suggests that recombination-stimulated changes in gene expression may be delayed for a 0.5–1 d in the digit region (see Figure 1C). | changes | 0.234375 | easy |
3ZXNP4Z39RL4GD163NL987ME58B7LL | biomed | Additionally, the activity of the rate-limiting enzyme for bile acid synthesis, CYP7a1, is reduced, although no changes at the mRNA level are noted. | changes | 0.315789 | easy |
39RRBHZ0AU1QWSJ60MFYM0DF6ZVVZP | biomed | Preliminary studies suggest that hyperactivity does not appear quickly when dox-reared mice are shifted to nonmedicated diets (J. L. J., unpublished data). | diets | 0.134615 | very easy |
3FCO4VKOZ4DQA7REM1Y5VCWUWC8E75 | biomed | AlphaA and alphaB were also shown to have sequence homology with several other proteins that are members of the small heat shock protein (hsp) family [7]. | members | 0.138889 | very easy |
324N5FAHSXBV7XKK0LCOZLP22QDVKY | biomed | TIF1 family members also contain a C-terminal plant homeodomain finger and bromodomain that are characteristic of chromatin remodeling factors. | members | 0.232143 | easy |
33P2GD6NRNSQPWP0VWVKKKYTUC0HKU | biomed | Thus, members of the ZnT and ZIP family with zinc as predominant substrate have opposite roles in cellular zinc homeostasis (43). | members | 0.25 | easy |
3V8JSVE8YYQ9PRNF9AO58PGR0AJEY6 | biomed | Still, other bona fide RanBP2 partners previously identified and described in the Introduction also become strong candidates to play a role in energy homeostasis. | Introduction | 0.134615 | very easy |
3R5OYNIC2C9H5WDB8IHHUKNGZF8TPM | biomed | However, computational prediction of the location of 5' upstream exons and the extent of the 3' UTR from genomic sequence has been extremely difficult. | sequence | 0.134615 | very easy |
3D3B8GE892RYLH4XACC03KM459Y9PX | biomed | One or both DNA ends formed by the break invade(s) the homologous sequence in the second mutant GFP copy, resulting in repair of the DSB via a homology-mediated gene conversion event. | sequence | 0.15 | very easy |
3O0M2G5VC62CWOIECSKC0MB9ECA497 | biomed | Then, Cre-mediated recombination in the presence of a cassette containing a floxed mutant allele removes the resident sequence and inserts the mutant gene (7). | sequence | 0.3 | easy |
35JDMRECC499302FF42Z1P9NVEYGEF | biomed | The sequence of DsRed1 has recently been modified and optimized for high levels of expression in mammalian cells by the introduction of 144 silent base pair changes corresponding to human codon usage preferences. | sequence | 0.34375 | easy |
3NKW03WTLM7UXPIK301HH9KP85CWQ6 | biomed | On the basis of secondary structure predictions and amino acid sequence conservation, we defined a novel PAX6 protein domain, which we have called the C-terminal peptide. | sequence | 0.363636 | easy |
3P4ZBJFX2V3X60SBPKQN5AGB13YFWQ | biomed | Antioxidant and DNA repair enzymes that provide protection from the effects of cigarette smoke are expressed in the progenitor cells for BC, normal bronchial epithelial cells (NBEC) [1]. | smoke | 0.134615 | very easy |
3S1WOPCJFGTJU2SGNAN2Y213N6AJEH | biomed | Antioxidant enzymes protect NBEC from reactive oxygen species produced by interaction with and metabolism of xenobiotics such as pollution and cigarette smoke [4-7] as well as those produced by normal cellular metabolism. | smoke | 0.302632 | easy |
3JVP4ZJHDPSO81TGXL3N1CKZGQH0I6 | biomed | Membrane cholesterol diminishes red blood cell haemolysis by the complement complex, whereas depletion of raft cholesterol abrogates association of all raft proteins with no significant effect on areas in the rest of the cell membrane and deformability [45,46]. | blood | 0.3125 | easy |
3UQ1LLR26A8MZFZ4AQXTIYO46HFLAQ | biomed | Several members of the bone morphogenetic protein (BMP) family of secreted signaling molecules are also expressed in stripes at sites where joints will form, including those encoded by the genes Gdf5, Gdf6, Gdf7, Bmp2, and Bmp4 (Storm and Kingsley 1996; Wolfman et al. 1997; Francis-West et al. 1999; Settle et al. 2003)... | joints | 0.138889 | very easy |
3D42WVSDH8V1V5NB4L8BQ71RCCWFYP | biomed | Mutations in either Gdf5 or the closely related Gdf6 gene also block formation of joints at specific locations, providing strong evidence that these molecules are essential for the joint formation process (Storm et al. 1994; Settle et al. 2003). | joints | 0.25 | easy |
3AJA9FLWSCYF558603M84J73MS0IFM | biomed | For example, the cyclophilin-like domain (CLD), the internal repeat (W1W2/IR), and zinc-finger rich (ZnF) domains of RanBP2 associate specifically with components of the 19S cap of the proteasome [14], the E2 SUMO-1-conjugating enzyme (Ubc9) [15], and the nuclear export receptor, CRM1/exportin-1 [16], respectively. | components | 0.138889 | very easy |
3MNJFORX8B43THDRTJ3EFA3YH60F5F | biomed | Normally cells accumulate H3-2meK9 and H3-3meK9 marks and HP1β protein on the sex chromatin as they progress to diplonema, but we observed mutant diplotene cells lacking these features. | protein | 0.138889 | very easy |
3ECKRY5B1QWLAMZ61FGF7BNLYXTZIQ | biomed | Having excluded a direct role in vesicle formation and membrane fusion, annexin A7 might act by its property as Ca2+-binding protein [17]. | protein | 0.220588 | easy |
3ZXV7Q5FJBOOS2M68TQMTG989OEFCH | biomed | In other studies, CLN3/battenin protein localization has been reported to partially overlap with late endosomes and lysosomes in non-neuronal cells [7], and to lysosomes, synaptosomes [8] and endosomes [9,25] in neurons. | protein | 0.225 | easy |
3VI0PC2ZAYK61DAUYS5ZUN3W260XOS | biomed | CAPAN-1 cells carry a deletion of BRCA2 on one homolog and codes for a protein truncated at amino acid 1981 on the other homolog. | protein | 0.265625 | easy |
35F6NGNVM8JSZQ9BCWN0UYWVZL2T7F | biomed | The numerous differences in T2R protein sequence between these two mouse strains suggests that T2Rs are broadly tuned receptors quite tolerant to sequence variation. | protein | 0.34375 | easy |
3QREJ3J433XSBS8QMHAICCR0BSBLK5 | biomed | Previous experiments with this technique revealed that deletion of Mtf1 from the liver after birth is no longer lethal under non-stress conditions (26). | experiments | 0.138889 | very easy |
30UZJB2POHC8D5XY9O2CE1E1EGQ35P | biomed | In our experiments, articular cartilage lacking Bmpr1a retains some normal characteristics, in that it maintains a very low proliferation rate, does not express Col1a1, and continues to express SOX9, a major transcription factor regulating expression of structural components of cartilage matrix. | experiments | 0.171053 | very easy |
3511RHPADVEEYWLLC1JFDODE6K4RL3 | biomed | In these experiments, the derivative expressing full-length BRCA2 yielded 10-fold more recombinants than controls expressing only truncated BRCA2 (S. Powell, personal communication, 2001). | experiments | 0.171875 | very easy |
3IVKZBIBJ09ODF28054MB6P3B5FSHM | biomed | Future experiments will address this question by overexpressing full-length Crb1 in a wild-type background. | experiments | 0.277778 | easy |
3QQUBC64ZEEOJSAIXD5MFY3RCWQNXY | biomed | In an attempt to fine-map the breakpoints of the disease-causing deletion we performed a series of experiments designed to refine the unknown intervals at the edges between definite deleted and definite diploid sequences. | experiments | 0.303571 | easy |
3S4TINXCC0NZOA7TTWDH5QC4J37OB5 | biomed | It has been reported that inhibition of cholesterol biosynthesis by chemical inhibitors of Dhcr7 also led to a disturbance of the Shh signaling with abnormal embryogenesis [27,28], and severe sterol deprivation can indeed inhibit the processing of transfected Shh in cultured mammalian cells [29]. | disturbance | 0.138889 | very easy |
3H6W48L9F4P9XDH53NMSH4UF39QWPF | biomed | Through this process, it is also possible that deficits in RanBP2 cause a disturbance in the equilibrium between Cox11, HK1, and RanBP2 by leading to an increase of the inhibitory activity of Cox11 over HKI that promotes the uncoupling of the interaction of HKI from RanBP2, ultimately causing HKI degradation. | disturbance | 0.233333 | easy |
307FVKVSYRF8I5ULXVMSMQK3JMG47P | biomed | If Shh signaling were defective in Dhcr7-/- embryos, these could have resulted in abnormalities of the staining patterns of these components, but no such disturbance was detected. | disturbance | 0.25 | easy |
31MCUE39BKM6T2MIQKL3IY5Q4P83GB | biomed | In support of this, AQP2-F204V can interact with wild-type AQP2 (Figure 5B), and when coexpressed with wild-type protein, AQP2-F204V can reach the cell surface (Figure 5C bottom right panel and 5D). | bottom | 0.138889 | very easy |
3MJ28H2Y1E8XZUQKSMM424CC97Q5OQ | biomed | Interestingly, an association between PGC-1α gene polymorphisms and obesity in humans has been recently reported [26]. | humans | 0.138889 | very easy |
3FDWKV9VCN2QK6VNG7FZICFNDO4MUA | biomed | Recent studies have also shown altered expression of PGC-1α and downstream mitochondrial target pathways in skeletal muscle of humans with insulin resistance and diabetes [22,23,24]. | humans | 0.2 | easy |
3MNJFORX8B43THDRTJ3EFA3YH6UF59 | biomed | However, due to practical constraints imposed by such a large animal model and due to the observation of differences between the MSUD cow model and MSUD humans [1], this model is also of limited utility. | humans | 0.227273 | easy |
3RKHNXPHGWWVUIVKVV2J3ZNJOK2UK8 | biomed | This will normally lead to a temporary remission of the disease in both mice and humans, followed by an exacerbation phase after delivery [7,10,11]. | humans | 0.240385 | easy |
36FQTHX3Z3RA2LE7AYTPHNETOCC3BQ | biomed | To date, only three active TACC genes have been cloned in humans [1-3], one in each of mouse [7], Xenopus laevis [8], D. melanogaster [4], and C. elegans [5,6]. | humans | 0.25 | easy |
3GL25Y6843UI1APILCQM2JER76GXM8 | biomed | These include signs of neurologic dysfunction such as seizures, stupor, lethargy, loss of motor activity, and respiratory difficulties [1]. | difficulties | 0.138889 | very easy |
3566S7OX5DJRQ6X2AD3QOSD072C71L | biomed | On the transcriptome level, the small number of animals per group and the low threshold used to detect gene expression could also result in false positives in the differentially expressed genes. | positives | 0.138889 | very easy |
3INZSNUD80QPWK1753L53Q5FRP2D9S | biomed | On the genome level, some of the eight small-effect QTL identified using a very low threshold value (P < 0.05) could be false positives. | positives | 0.3 | easy |
3UUSLRKAUL3LI1DEQ6NLPUE9WZED7G | biomed | Moreover, expression of alpha-crystallin, particularly alphaB, was shown to not be restricted to the lens. | lens | 0.138889 | very easy |
33J5JKFMK6YX6RGWTGQFCC9SACD3Q2 | biomed | The results of the current study support the hypothesis that alpha-crystallin plays an active role in the differentiation and growth of lens fiber cells. | lens | 0.175 | very easy |
3DA79LNS59VAY78OAKKAHHKFUJBT35 | biomed | The expression of these two proteins in the lens epithelium, however, is not uniform throughout different regions of the anterior epithelium. | lens | 0.175 | very easy |
31MCUE39BKM6T2MIQKL3IY5Q4P43G7 | biomed | This indicates that alphaA may play a greater role in maintaining the transparency of the lens then alphaB. | lens | 0.183333 | very easy |
3SBX2M1TKDNIONZ0TUVYMH1YOCDQ4E | biomed | Our results support and refine the hypothesis, indicating that huntingtin is required for proper mesoderm patterning and for normal regional restriction of the expression of a subset of growth and transcription factors. | factors | 0.138889 | very easy |
3BFNCI9LYKQN09BHXHH9CLSX5MQ73D | biomed | It is also possible that evolutionary factors may be responsible for reduced pseudogene content of clustered olfactory receptors - gene conversion between neighboring olfactory receptors could rescue inactivating mutations in clustered genes, but not singletons. | factors | 0.15 | very easy |
31ODACBENUF1Q81BJVRGKKH42SGSQN | biomed | The differentiation of sensory neurons of dorsal root ganglia (DRG) has been studied extensively with respect to inductive events that specify neuronal fate [2,3], as well as the involvement of late target-derived neurotrophic factors in the control of neuronal survival [4]. | factors | 0.175 | very easy |
3WA2XVDZEMH767D93RTDPYWY10QE66 | biomed | Binding partners of Annexin A7 such as sorcin might represent additional factors [28]. | factors | 0.315789 | easy |
3PCPFX4U40QSM3WPDBRHDLYPD2MFQR | biomed | Analysis of the mechanisms by which transcription factor programs can be shifted over time to control different complements of downstream genes and thus different aspects of neuronal and cellular fates in progenitor cells or post-mitotic neurons may provide further insight into the way in which transcription factors ac... | factors | 0.339286 | easy |
3ICOHX7ENCBCSWRU12DWGXM7OXA0EX | biomed | The cerebellum is in charge of the smooth coordination of somatic motor activity, regulation of muscle tone, and mechanisms that influence and maintain equilibrium [30]. | charge | 0.138889 | very easy |
3UOMW19E6D6WQ5TH2HDD74IVKU05CO | biomed | Diminished response to dDAVP, diminished abundance of mature glycosylated protein in mutant animals, and the transport of a fraction of mutant protein beyond the ER in MDCK cells are all consistent with the notion that AQP2-F204V misfolding is limited and that it may retain some residual water transporting activity. | response | 0.194444 | very easy |
3VMV5CHJZ8FBSJKC5ZRU0B9OYOLTGI | biomed | Marked differences were found in the thrombotic response among the two inbred strains, B6 and A/J, and the observed differences were not correlated with change in coagulation or platelet function. | response | 0.279412 | easy |
38F60IALAGHEHF9RRX2RFJM8R8P0TH | biomed | BMP2 and BMP7 are thus secondary signals produced in response to SHH activity. | response | 0.291667 | easy |
3HJ1EVZS2OJXISVW6VFFH2JX6YJR3V | biomed | Its development proceeds through three overlapping steps starting with retinal progenitor cell (RPC) proliferation, followed by birth of post-mitotic retinal transition cells (RTCs, also referred to as precursors), and ending with terminal differentiation of seven major cell types (Figure 1A) [1]. | steps | 0.140625 | very easy |
338GLSUI43B4ZJB25FGM8LDQVQ2FSB | biomed | These findings demonstrate very distinct activities of one transcriptional regulator at different developmental steps within a committed post-mitotic neuronal lineage. | steps | 0.176471 | very easy |
334ZEL5JX6FY5WOV4IZCVFM4NRTSOA | biomed | This discovery has led to the identification of other disorders of embryonic development caused by mutations in genes encoding other enzymes in the post-squalene steps of cholesterol biosynthesis. | steps | 0.284091 | easy |
351S7I5UG9WNO85TG9QLOPVC1Z9NJA | biomed | The different timing of lethality in the Capn4 knockouts might also be a consequence of the different genetic backgrounds of the two transgenic lines, which has been observed to influence the phenotype of transgenic mice on a number of occasions [37]. | occasions | 0.325 | easy |
3N3WJQXELSQXUC40XB4ECG56USPL2J | biomed | An attractive alternative, favored by Davies et al [26], is that the association of RAD51–BRCA2 is required to maintain RAD51 in a form that is in a state of 'readiness' (Fig. 2a). | association | 0.142857 | very easy |
3QHITW7OYO9XQCFH2V5PZKNYGM9AQ9 | biomed | To confirm these findings, the staining was repeated in kidneys taken from two further mice for each class, wild-type or mutant, with or without dDAVP treatment, with identical results. | findings | 0.142857 | very easy |
3IVKZBIBJ09ODF28054MB6P3B5LHSH | biomed | To integrate these findings, we investigated the genetic relationship of Sry, Sox9, Fgf9, and Wnt4 in the regulatory network that governs the gonadal field. | findings | 0.21875 | easy |
32PT7WK7DMF3HICROUKVCD2TRYL3DW | biomed | However, earlier findings of normal proprioceptive afferent trajectories in chicken embryos despite injection of function-blocking NT-3 antibody into the spinal cord (Oakley et al. 1995) led them to discount this possibility. | findings | 0.232143 | easy |
37OPIVELUU3KDJGEJ5IVQ6VXPZDAHD | biomed | Taken together these findings suggest that D2R-mediated signaling could play a critical role in reversal learning but are insufficient to prove it. | findings | 0.277778 | easy |
3G3AJKPCXLSRXPQMK4CSZ340NMN4YQ | biomed | These findings identify Sam68 as the first RNA binding protein to regulate mesenchymal cell differentiation and the challenge will be to identify the specific RNA targets that it regulates during this process. | findings | 0.296875 | easy |
3D4BBDG7ZHWTCQ6DOYPKS7KB6XBC35 | biomed | The exact nature of the spliced transcript might be unimportant, such that several isoforms might be produced simply because multiple functional splice sites are available. | sites | 0.2 | easy |
3CVDZS288H011OYXLIK0WCEK31KMF6 | biomed | Both Annexin A7 isoforms described in brain tissue seemingly are expressed by neurons and astrocytes, which was shown using total cell extracts of cultured neuo-2a, PC-12, and C6 cells. | tissue | 0.142857 | very easy |
30EMX9PEVKJFF53G6Q7JOY5V3MOKSN | biomed | Overexpression of Shh in the distal lung epithelium resulted in the absence of functional alveoli and an increase in interstitial tissue caused by an increased proliferation of both epithelial and mesenchyme cells [26]. | tissue | 0.2 | easy |
3W3RSPVVGSR6EOD2GVEKIZ0YDJ9LU2 | biomed | This is consistent with previous work in which we have shown that PGC-1α physically associates with PPARδ in muscle tissue and can powerfully activate it even in the absence of ligands (Wang et al. 2003). | tissue | 0.216667 | easy |
3BCRDCM0ODUAS75JZD4GNT93LXMK6W | biomed | Although the role of APC in the initiation of human colorectal cancer is well established, its role in other tissue and developmental processes are not well understood. | tissue | 0.234375 | easy |
31ANT7FQN82N7D4XO9REIVFBXL7H59 | biomed | The HG9 strain represents a major epistasis-based obese mouse model and promises to aid in the understanding of obesity and specifically the modulation of adipose tissue deposition by Gh. | tissue | 0.265625 | easy |
3XDJY5RK5SLAGG6HA3F3WIYNRXE4US | biomed | Thus, impaired gas exchange, as opposed to poor inflation and alveolar tension, may be the cause of respiratory failure in these pups. | gas | 0.142857 | very easy |
389A2A304OIXVY7G5B71Q9M43MPC0A | biomed | Morphometric analysis of the tail indicated a difference in the collagen content of the tail in the A/J mice. | difference | 0.142857 | very easy |
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