id stringlengths 30 30 | corpus stringclasses 3 values | sentence stringlengths 10 1.38k | token stringlengths 1 16 ⌀ | complexity float64 0 0.86 | difficulty stringclasses 5 values |
|---|---|---|---|---|---|
3FHTJGYT8N0D0RR5OIIAV18R9L0GP0 | biomed | We could not detect any significant difference in the distribution and aspect of PML nuclear bodies between control and p150CAF-1-depleted ES cells (Figure 2D). | difference | 0.216667 | easy |
3QGHA0EA0J07TJGVKI4RMKPQM5BWBU | biomed | Matsuno et al [32] reported no difference in bleeding time for tPA-/-, uPA-/-, PAI-1-/- mice compared to WT mice, and the assay was similar, but the tail clip segment was considerably shorter and bleeding times reduced compared to the times reported in our study. | difference | 0.279412 | easy |
33NOQL7T9OZSLGNTST4OUMT7V1U8ZX | biomed | For example, a QTL for PROP avoidance has been suggested on chromosome 7 [16], and we observe a suggestive QTL for quinine taste on chromosome 8 (Figure 2); in neither case are Tas2rs found at these loci (data not shown). | example | 0.216667 | easy |
3KL228NDMVMCP0UPBQD2ZKMSFBPGKU | biomed | It is possible that its checkpoint function evolved independently in worms and budding yeast. | checkpoint | 0.142857 | very easy |
356ZPKYPUHHDMIC5IO4G21FVEHLPY2 | biomed | This should pave the way for novel strategies designed to incorporate the use of compound transgenics or tissue recombination or chimeric analyses where several compartments are to be tagged. | use | 0.142857 | very easy |
3H781YYV6TID85OLZ41608OCL9ZTEW | biomed | While this approach is promising, constant exposure to antibodies that recognize an epitope highly enriched in the brain may have unexpected side effects that will limit its long-term use. | use | 0.157895 | very easy |
33Q5P9PUSPMUXJD695KTW8PQLSACZ2 | biomed | The use of forward genetics to define novel loci of interest in human disease has become increasingly viable with the implementation of large-scale mutagenesis programs. | use | 0.264706 | easy |
39XCQ6V3KY47AOKGSQ0AL4QLO7X562 | biomed | Animals use the gustatory system to provide information about food quality. | food | 0.142857 | very easy |
3VLL1PIENQOV68A9ZATKR8J7A6SZOL | biomed | Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5]. | ear | 0.1875 | very easy |
306996CF6WKESI0SNUF6TUZWQS31B1 | biomed | In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11]. | ear | 0.233333 | easy |
3PEG1BH7AERGYJMEV4LOY9VVZYXKBH | biomed | Expression of pendrin mRNA in the inner ear has been found in several places including the cochlea, the vestibular labyrinth and the endolymphatic sac [8]. | ear | 0.35 | easy |
3N3WJQXELSQXUC40XB4ECG56USUL2O | biomed | Comments and requests should be addressed to JB or SM. | Comments | 0.142857 | very easy |
39AYGO6AFFKB0DQMWQWWFLQ7FSRN64 | biomed | In rare mutant cells that survive to diplonema, we observed sex chromatin abnormalities. | sex | 0.144737 | very easy |
30U1YOGZGAW71ZX6E9LWKLA5JDRSDI | biomed | However, expression of Sertoli cell markers was not previously detected in these mutants during fetal stages [ 8, 29], leading to the conclusion that Wnt4 was not involved in primary sex determination in the gonad. | sex | 0.15 | very easy |
3S8A4GJRD33O8IZVYHINP2KK1VTV6T | biomed | Normally cells accumulate H3-2meK9 and H3-3meK9 marks and HP1β protein on the sex chromatin as they progress to diplonema, but we observed mutant diplotene cells lacking these features. | sex | 0.205882 | easy |
37NXA7GVST66R322LLOPEL2HRQNVL6 | biomed | Apart from the obvious gender-specific diseases such as cervical or prostate cancer, sex influences susceptibility to nearly all highly prevalent diseases that affect both women and men, including atherosclerosis and diabetes and their precursor conditions of hyperlipidemia, obesity, and insulin resistance. | sex | 0.21875 | easy |
3E9VAUV7BWE6ZE63T5MJC6Q0FVQAYC | biomed | Here we report the application of this integrated approach to study the significance of sex on the genetic determinants of obesity and the associated regulation of liver gene expression in an F2 intercross derived from the inbred strains C57BL/6J (B6) and C3H/HeJ (C3H) on an apolipoprotein E null (ApoE−/−) background. | sex | 0.234375 | easy |
37NXA7GVST66R322LLOPEL2HRQILVR | biomed | For example, the BXD RI lines exhibited a range of quinine sensitivity, with several strains having similar sensitivities to that of B6, some strains with sensitivities similar to that of D2, and a third group with a more intermediate phenotype (Figures 1, 7). | Figures | 0.144737 | very easy |
3SZYX62S5G0QEOYLB052RIQHJIB75X | biomed | Notably, A. thaliana does not appear to have a meiotic checkpoint activity that eliminates mutant meiocytes in a manner analogous to organisms such as mice, budding yeast, and female Drosophila [11,57], and mammalian TRIP13 is more similar to Arabidopsis PCH2 than the fly or worm proteins (Figures 1A and S1). | Figures | 0.194444 | very easy |
35ZRNT9RUIYULF3GE3YBN7ESVBV3OU | biomed | Compared to wild-type, mutant protein is enriched in the high-mannose, core-glycosylated form (31 kDa) and deficient in nonglycosylated (29 kDa) and complex glycosylated (35–45 kDa) forms. | forms | 0.145833 | very easy |
3QXFBUZ4ZKGQSWZ154H457VQH2MUG4 | biomed | It is becoming increasingly clear that many forms of glaucoma have a genetic component [6,7], and much current research is focused on identifying chromosomal regions and genes that contribute to glaucoma [8-10]. | forms | 0.1875 | very easy |
36D1BWBEHN1H0UMLXN5TCTKVUXF2M2 | biomed | In this report, we describe the development and characterization of two genetically engineered mouse models that are phenotypically very similar to MSUD patients with the classic and intermediate forms of the disease. | forms | 0.191176 | very easy |
308KJXFUJR6AIS79JZZK4PYL0T8ATN | biomed | In fact, the most likely candidates for a cellular correlate of olfactory memory appear to be the neuronal connections in the piriform cortex due to the associational connectivity [5] and the expression of several forms of cellular and synaptic plasticity [7,20–23]. | forms | 0.3125 | easy |
3A9LA2FRWSEW9WO7UFA9AE6VQKNHXP | biomed | The exact molecular function of SEPW1 protein is unknown to date, but a role as antioxidant has been proposed due to its ability to bind glutathione (35). | ability | 0.147059 | very easy |
3FSEU3P2NR0P1UGYHLGBZ0MDCCTRRT | biomed | On the other hand, in the visual platform version of the water maze task, motor ability for swimming in ADAM11-deficient mice was normal. | ability | 0.203125 | easy |
3WRBLBQ2GR8ACANL7X3KG07J1DOG0T | biomed | We verified the ability of Prx1::cre to recombine the conditional Bmp2 and Bmp4 alleles at earliest limb bud stages using in situ hybridization. | ability | 0.203125 | easy |
3PR3LXCWSFZ3UQ6OW3MHXX877799XL | biomed | The data herein show that the multi-chaperone role of RanBP2 extends also to its LD in light of its ability to associate to distinct folding species of Cox11 and to prevent HKI from being degraded. | ability | 0.267857 | easy |
3CMV9YRYP31X08284WA6BXRNW3BLJ6 | biomed | Although the progression of amyloid deposition was sharply arrested by this approach, we found that a substantial amyloid burden remained even after long periods of transgene suppression. | approach | 0.147059 | very easy |
3OEWW2KGQJBS375D7S4N0G04MOJODC | biomed | The strength of this approach is that mutations are tested in a genomic setting and expressed from the endogenous promoter, ensuring physiological expression levels and correct spatio-temporal profiles. | approach | 0.173077 | very easy |
3IH9TRB0FBZOFQEYT47NFH39LINI1R | biomed | We have employed the same approach to analyse the genetic basis of disease inheritance in the (129 × C57BL/6) hybrid strain, the most common genetic background in gene-targeted mice. | approach | 0.214286 | easy |
34OWYT6U3WH64VHTXHMGUNLSJUAI9Z | biomed | We next determined whether the RMCE approach could be used to target mutations at the p53 allele in somatic cells (Figure 1, path B). | approach | 0.222222 | easy |
31N9JPQXIPIRX2A3S9N0CCFXO67NH5 | biomed | One criticism of the speed congenic approach is the potential for QTL to reside among unwanted donor alleles not eliminated during backcrossing. | approach | 0.25 | easy |
31ANT7FQN82N7D4XO9REIVFBXLD5H3 | biomed | Animals carrying the at allele express only the ventral-specific Agouti transcript (Bultman et al. 1994; Vrieling et al. 1994) and have black dorsal hairs and cream-colored to yellow ventral hairs, with a sharp boundary at the level of the limb–body wall articulations and in the middle of the whisker pad. | middle | 0.147059 | very easy |
3IKMEYR0LWVMA6MICBSDXGSR5THK2E | biomed | The Capn4 targeting strategy employed by Arthur and colleagues involved disrupting the C-terminus of the calpain small subunit by insertion of the PGK-Neo cassette into the middle of exon 9, which caused truncation of the protein [31]. | middle | 0.161765 | very easy |
335VBRURDJ0UOQF71YWP98N0R1YE9H | biomed | The sequence of this large protein (3418 amino acids) offers very little clue to its function, although there are eight repeated segments (termed BRC repeats) in the middle of the protein that are highly conserved among mammalian orthologs [7,8]. | middle | 0.289474 | easy |
36GJS3V78VQHEGO7T5DQY5MF0NNGJV | biomed | An attractive alternative, favored by Davies et al [26], is that the association of RAD51–BRCA2 is required to maintain RAD51 in a form that is in a state of 'readiness' (Fig. 2a). | alternative | 0.147059 | very easy |
3L2OEKSTW9ASGQDOW725GFK5P7L8Y1 | biomed | Accordingly, activation of muscle PPARδ essentially recapitulates the effects of exercise training even in the absence of training itself. | exercise | 0.147059 | very easy |
3126F2F5F83FGDVEINSMVYNFW5LPES | biomed | These progressive changes in oxidative capacity in conjunction with eventual changes in type I muscle fiber lead to a dramatically improved exercise profile and protection against obesity. | exercise | 0.225 | easy |
3Y7LTZE0YTMQJDU6VW5TQEBWSTEUZT | biomed | Loss of p150CAF-1 did not affect PML bodies in ES cell nuclei, showing that nuclear architecture is not generally altered. | bodies | 0.261364 | easy |
341H3G5YF0EA3RIQXPR917NPC4BZ0W | biomed | It is usually associated with a mild form of α-thalassaemia, caused by reduced expression of structurally intact α-globin genes, and characterised by the presence of β-globin tetramers (haemoglobin H inclusion bodies) in peripheral red blood cells. | bodies | 0.433333 | neutral |
3UQVX1UPFSHKXGFE8IIVEWDIRUK20X | biomed | Transplanted cells were observed to proliferate, resulting in thousands of donor-derived erythrocytes 7 d later. | thousands | 0.15 | very easy |
3Q7TKIAPOTAKXM2GU0OV8ZWARKCDLK | biomed | It has also been reported that 75% of female patients (23 out of 31 females) with RA exhibit clinical remission during the course of pregnancy [5]. | course | 0.15 | very easy |
3KQC8JMJGCSKTYHTAQ3L3YHRJPGH3J | biomed | A breakthrough in the availability of spectrally distinct autofluorescent proteins came with the cloning of six anthozoan fluorescent proteins all having 20-30% identity to wtGFP [12]. | availability | 0.15 | very easy |
3RQVKZ7ZRKJYFRFYTH34TBN5Z9I27R | biomed | Of course, the availability of an experimental crystal structure will make the design of inhibitors easier and we are continuing our efforts to crystallize CLN2 from different sources. | availability | 0.25 | easy |
307FVKVSYRF8I5ULXVMSMQK3JMM74Y | biomed | However, differentiation defects in any Rb KO neuron could be an indirect effect of ectopic division and/or apoptosis (Figure 1B). | effect | 0.15 | very easy |
3P458N04Q1HSU6LPBU72NA0T11YX2G | biomed | A similar effect might be at work in the two Capn4 transgenic lines. | effect | 0.191176 | very easy |
3KI0JD2ZU1IMXSYZGJF7JO4HFDS76J | biomed | Past experiments seeking to explore the possible involvement of dopamine D2Rs in associative learning have utilized low to moderate doses of drugs [2,5,6] and site-specific administration [7,9] in order to avoid the confounding effect that locomotor disruption associated with acute D2R blockade can have on learning performance in rodents. | effect | 0.202381 | easy |
3X4Q1O9UBHMCMY43GF110OQ80DGO7J | biomed | To investigate the role of this protein during mouse development, we generated a conditionally deleted allele of the Atrx gene in mouse embryonic stem (ES) cells, and used these cells to examine the effect of ablating expression of the full-length Atrx protein in ES cells and in mouse embryos. | effect | 0.238636 | easy |
3XU80RHWHZGBZIC2VXOLJE0TSKW44B | biomed | In one study using CF mice on different genetic backgrounds, a region on mouse chromosome 7 was shown to ameliorate intestinal blockage and the effect was in part due to a calcium-regulated Cl-channel which compensated for loss of CFTR function [16,17]. | effect | 0.267857 | easy |
39WICJI5ATS6KJHNGC9S35LWFF2Z3W | biomed | While a number of genetic mutations have been identified, these account for only a small percentage of the CVD in human populations. | percentage | 0.15 | very easy |
3ICOHX7ENCBCSWRU12DWGXM7OX4E05 | biomed | In natural environments, color variation is a nearly universal mechanism for recognition, camouflage, or both; consequently, a large number of pigment patterns have been characterized from an evolutionary and ecological perspective (Boughman 2001; Jiggins et al. 2001). | perspective | 0.15 | very easy |
39O0SQZVJN7FJBWJ87I5UJVDB067RH | biomed | Goiter is variable and generally develops around puberty [3]. | puberty | 0.15 | very easy |
3FHTJGYT8N0D0RR5OIIAV18R9LVPG4 | biomed | Moreover, the observed transcriptional shift in ETS signaling is paired with the onset of appropriate regulation of neuronal subtype specification and establishment of axonal projections into the target area. | regulation | 0.15 | very easy |
3TX9T2ZCB913BHJBQWKU82WTD8RWZU | biomed | If this conclusion is correct, the individuals at greatest risk for BC will be those with the most extreme smoking history combined with sub-optimal regulation of the largest number of antioxidant and DNA repair genes. | regulation | 0.328125 | easy |
3SX4X51T809U5021NIDLAFSY1LROAF | biomed | A biomarker combining polymorphisms that affect regulation with those that affect function of antioxidant and DNA repair genes is likely to be the most accurate for identifying individuals at risk for BC. | regulation | 0.359375 | easy |
31KPKEKW4ADELTFARBB6FPGML0RB02 | biomed | The incidence of CIA is sex dependent, like the incidence in RA, although different species and different variants of the disease could lead to both male and female predominance. | species | 0.15 | very easy |
3E6L1VR4XWMZCLD5Y2DJ7GHYD236FG | biomed | The sequence conservation and the presence of multiple members within a species may imply functional importance associated with the genes. | species | 0.1875 | very easy |
3O0M2G5VC62CWOIECSKC0MB9ED2946 | biomed | Evidence suggests that the production of reactive oxygen species is a major effect of acute cadmium toxicity (68,69), and exposure of cultured cells or animals to cadmium is associated with depletion of reduced glutathione, lipid peroxidation and DNA damage (70–73). | species | 0.25 | easy |
33BFF6QPI1B2QOCI5PPL41REYDYW33 | biomed | Clinical studies have shown that affected individuals hyperabsorb all dietary sterols (thus have lost the ability to restrict the sterol species absorbed) and have lost the ability to excrete sterols into bile [8,9]. | species | 0.263889 | easy |
372AGES0I459YQ2AQKM3OI81DTFXRW | biomed | Other E2fs may also exist in isoforms since at least two mRNA species have been detected for E2f1 and E2f2 [16]. | species | 0.27381 | easy |
3QI9WAYOGQB8GQIR4MDIEF0D2RZS6L | biomed | Mammalian lung is unique in that it is fully developed, but does not function for gas exchange until at the moment of birth; the majority of structural development and maturation takes place in utero. | moment | 0.15 | very easy |
3SX4X51T809U5021NIDLAFSY1LRAO1 | biomed | Studies from the tet-off tau mice suggest that protein clearance may in fact not be required for cognitive improvement following transgene suppression [61]. | Studies | 0.15 | very easy |
36FFXPMST9O9FNAFTONDR1F2EGCHOE | biomed | Studies over the last 10 y have begun to elucidate some of the signaling pathways that contribute to the early stages of joint formation. | Studies | 0.1625 | very easy |
3D3B8GE892RYLH4XACC03KM45809PX | biomed | Studies with human foreskin fibroblasts demonstrated that Annexin A1, A4 and A5 are all present in the nucleus at higher concentration than in the cytosol [31]. | Studies | 0.166667 | very easy |
3VEI3XUCZRX4PH0J4TCMU5MYBUBPR5 | biomed | Studies with human, avian and chicken CSRP1 have shown that this protein is localized at adhesion plaques and in association with filamentous actin, and interacts with the adhesion plaque protein zyxin, as well as the actin-cross-linking protein alpha-actinin (54–57). | Studies | 0.236842 | easy |
3LXX8KJXPW9G0HSWVCZLEKHEV3A9OM | biomed | Plasma and hepatic plant sterol levels in Abcg8-/- and Abcg5/Abcg8 knockout are increased similarly with marked decreases in cholesterol levels. | plant | 0.15 | very easy |
3SZYX62S5G0QEOYLB052RIQHJIH753 | biomed | A typical western diet contains relatively equal amounts of cholesterol and non-cholesterol sterols, mainly plant sterols, of which about 55% of the dietary cholesterol is absorbed and retained compared to ~1% of the dietary non-cholesterol sterols [1-3]. | plant | 0.184211 | very easy |
338GLSUI43B4ZJB25FGM8LDQVQ2SFO | biomed | TIF1 family members also contain a C-terminal plant homeodomain finger and bromodomain that are characteristic of chromatin remodeling factors. | plant | 0.3 | easy |
3ROUCZ907FUJ74W2X1I3BAC3Q2VOOE | biomed | On the other hand, since feeding is intermittent, a slow, but continuous secretion during post-prandial periods could easily negate any mild temporary increase in tissue and plasma plant sterol levels in heterozygous animals. | plant | 0.391304 | easy |
3XABXM4AJ15J7OM25XLB3TH3QY4Q8G | biomed | These findings are in complete agreement with earlier studies that utilized rats and fairly selective D2R antagonists [3-8], as well as even very extensive 6-OHDA lesions [1,10,11] in associative and operant learning paradigms. | learning | 0.15 | very easy |
3ZICQFRS31I75COG1J4176QBUAVZZN | biomed | One might then ask: "How then could the role of D2Rs in associative learning be dissociated from motor behavior?" | learning | 0.176471 | very easy |
3N5YJ55YXG3CNF2PM3D8VQSTBBMANM | biomed | Taken together these findings suggest that D2R-mediated signaling could play a critical role in reversal learning but are insufficient to prove it. | learning | 0.321429 | easy |
3YGYP1364194MWO6OEZUQGH3BFANR7 | biomed | In this study, we sought to determine the contribution of dopamine D2 receptor-mediated signaling to the various stages of associative and reversal learning. | learning | 0.340909 | easy |
3QD8LUVX4XYKT34CTD90LH35LBPX5H | biomed | Positional cloning also permitted the identification of the Tas2r responsible for the majority of variance of phenylthiocarbamide (PTC) taste sensitivity in humans [18]. | identification | 0.15 | very easy |
3H4IKZHALBIJ7YWEV7IDHWCTAIGNNE | biomed | Thus, the identification and functional characterization of new members of the TACC family in other organisms, alternatively spliced isoforms of each TACC and comparison of the phylogenetic relationship of these genes relative to other members of the coiled coil superfamily will resolve this issue and provide clues to the evolution of TACC function. | identification | 0.2 | easy |
386659BNTLHD8VXIPEIH9D3DZO601E | biomed | This discovery has led to the identification of other disorders of embryonic development caused by mutations in genes encoding other enzymes in the post-squalene steps of cholesterol biosynthesis. | identification | 0.220588 | easy |
3H6W48L9F4P9XDH53NMSH4UF39LPW3 | biomed | Virtually-multiplexed transcript abundance data are highly suited to identification of genes that have correlated transcript abundance values. | identification | 0.266667 | easy |
3D4BBDG7ZHWTCQ6DOYPKS7KB6XHC3B | biomed | Adequate animal models are useful tools for the identification of genes involved in complex human diseases. | identification | 0.315217 | easy |
3P4ZBJFX2V3X60SBPKQN5AGB14WWF7 | biomed | In contrast to the affected child, mice heterozygous for a null mutation of Fog2 appear normal. | child | 0.25 | easy |
3ECKRY5B1QWLAMZ61FGF7BNLYXZZIW | biomed | Nevertheless, the overall density of cones was only modestly increased in this patient (approximately 2-fold), suggesting that there might be additional factors that contribute to the very large, light-adapted ERG seen in this disease. | patient | 0.15 | very easy |
34O39PNDK682LNZ9LOULZLH9URPBR1 | biomed | Apart from the obvious gender-specific diseases such as cervical or prostate cancer, sex influences susceptibility to nearly all highly prevalent diseases that affect both women and men, including atherosclerosis and diabetes and their precursor conditions of hyperlipidemia, obesity, and insulin resistance. | cancer | 0.336957 | easy |
36QZ6V1589DTI18S04BLULET5DMSUS | biomed | However, our congenics provide the ideal foundation genomic resource to test for the influence of any of these possible effects. | influence | 0.220588 | easy |
3RWO3EJELH9GWC126ZX7OE4L7WI1PM | biomed | The results of a recent study of RA in women, however, indicate that pregnancy history does not increase the incidence of the disease later in life [8]. | pregnancy | 0.152778 | very easy |
3HKIF5DF6YXS84BY7TMD9B8C4HDG90 | biomed | It has also been reported that 75% of female patients (23 out of 31 females) with RA exhibit clinical remission during the course of pregnancy [5]. | pregnancy | 0.183333 | very easy |
3HY86PZXPYICZLCCXLHWU25HTPAE18 | biomed | Pregnancy in mice, like pregnancy in women, normally causes remission of arthritis [5,10], while exacerbation often occurs postpartum [7,10,11]. | pregnancy | 0.289474 | easy |
3BJKPTD2QCC2H9TQLAL6ZFNV0XWRTC | biomed | The basis for this interesting but relatively nonspecific finding is unknown. | basis | 0.15625 | very easy |
3OLZC0DJ8JF412UW0IRCM5APANMIVA | biomed | The basis for the observed abnormalities of cardiac heart rate, including a blunted response to β-adrenergic stimulation, is unknown, but could be related to the effects of late-stage growth arrest and corresponding derangements in energy metabolism on sinus node function. | basis | 0.352941 | easy |
3JMQI2OLFZ5ALM516D4ALR0ZWEJDNR | biomed | We could not detect any significant difference in the distribution and aspect of PML nuclear bodies between control and p150CAF-1-depleted ES cells (Figure 2D). | aspect | 0.266667 | easy |
3H4IKZHALBIJ7YWEV7IDHWCTAILNNJ | biomed | Although no embryonic lethality was noted, these knockout pups exhibited a number of developmental abnormalities and died within 24 h after birth. | abnormalities | 0.15625 | very easy |
3R0WOCG21M9NGCPA3EGWZMST4B5DUE | biomed | Chaf1a+/- mice were born at a Mendelian frequency, were of normal size and weight, displayed no obvious abnormalities, and were fertile. | abnormalities | 0.2 | easy |
33K3E8REWWV3GLNERBG3X1DWN1W8X0 | biomed | Examination of chromatin and nascent transcription in mutant cells that progressed to diplonema revealed sex chromatin abnormalities, as discussed below. | abnormalities | 0.232143 | easy |
389A2A304OIXVY7G5B71Q9M43LS0CZ | biomed | As well as colorectal polyps, these individuals can develop extracolonic symptoms, among which are upper gastrointestinal tract polyps, congenital hypertrophy of the retinal pigment epithelium, desmoid tumors, disorders of the maxillary and skeletal bones, and dental abnormalities [6]. | abnormalities | 0.285714 | easy |
32CXT5U14G3BZHTJM65GDUESTJA8U3 | biomed | ADAM11-deficient mice survived more than one year without ataxia or tremor, showed no abnormalities in body weight gain, spontaneous motor activity, muscle strength, or walking patterns, and exhibited no apparent anatomical-histological changes. | abnormalities | 0.333333 | easy |
3RBI0I35XE36FT7IKQ79PYCU9LZ3YA | biomed | A recent report estimates that the carrier frequency of MLIV in the Ashkenazi Jewish population is 1 in 100, and mutations have been reported in Jewish and non-Jewish families [6-9]. | frequency | 0.15625 | very easy |
3DGDV62G7O9NLXJYP3XLTXEQZ2W2P4 | biomed | The frequency of targeting was 4% (12/300 puromycin-resistant clones, analyzed by Southern blot and long-range PCR, Figure 2). | frequency | 0.15625 | very easy |
3VQTAXTYN3LU1FRQPIPQ4W4T1P0UBT | biomed | A limited number of studies have identified variation within CAST coding sequence; so sequencing candidates gave us the opportunity to estimate the SNP frequency in coding sequence relative to B6. | frequency | 0.283333 | easy |
386T3MLZLNVVJVH3OZRWONQLDV4800 | biomed | Interestingly, from studies with the same cross, we have previously detected a significant QTL denoted Pregq2 for the trait 'pregnancy frequency' in the very same region as Cia40 (peak at 64–70 cM on chromosome 11) (Liljander M, Sällström MA, Andersson S, Wernhoff P, Andersson Å, Holmdahl R, Mattsson R, unpublished data). | frequency | 0.421875 | neutral |
3ZICQFRS31I75COG1J4176QBUA1ZZT | biomed | These data are not reflected by a change in the in vivo bleeding time. | bleeding | 0.15625 | very easy |
3IKDQS3DQE082TOW91W7WDM0PF8CI5 | biomed | A congenic strain (specific for a homosomic region from A/J and the remaining Chr and background is from B6 mice) of A/J chromosome 17 that includes the Plg gene was tested in the bleeding assay. | bleeding | 0.222222 | easy |
39KV3A5D187RKQWWNWIAKT09X2J7SZ | biomed | These pertinent olfactory behaviors were assessed in a go/no-go operant conditioning task, which provides a quantitative, robust, and reproducible behavioral tool [3]. | task | 0.25 | easy |
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