razvanalex/CWI-CompLex-single · Datasets at Hugging Face

id stringlengths 30 30	corpus stringclasses 3 values	sentence stringlengths 10 1.38k	token stringlengths 1 16 ⌀	complexity float64 0 0.86	difficulty stringclasses 5 values
3EN4YVUOUCSS02JXIFDUMRMA3CLXJ4	biomed	The cross consists of 334 animals of both sexes, allowing us to specifically test for the dependence of QTLs on sex.	dependence	0.1875	very easy
3BS6ERDL9372E1Z97WITJGED1OP6D5	biomed	We focused on one of the four lines, line 107, to examine in more detail the time dependence and extent of transgene suppression following either acute or chronic treatment with dox.	dependence	0.220588	easy
3N3WJQXELSQXUC40XB4ECG56USV2L6	biomed	The fusion of EWS with Pea3 could circumvent a need for activation through specific cofactors while still maintaining ETS site dependence, thus rendering EWS-Pea3 less sensitive to the cellular context than endogenous ETS transcription factors.	dependence	0.411765	neutral
3X878VYTIEIIGLRAHCIBDUHU8CV7FM	biomed	To our knowledge, this has not been directly described for any other transcriptional factor.	factor	0.1875	very easy
3UQ1LLR26A8MZFZ4AQXTIYO46GMALK	biomed	With this reference point, we then designed experiments to examine the effects of precocious post-mitotic expression of the same ETS transcription factor on sensory neuron differentiation.	factor	0.194444	very easy
33KGGVH24UHL5L3TSQ7OIRQO9VKX1Z	biomed	Among histone chaperones, chromatin assembly factor 1 (CAF-1) is a three-subunit (p150, p60, and p48) complex which promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair [9,10].	factor	0.267857	easy
3V0TR1NRVA2Q17SJ4YYCWHMTKUM4AG	biomed	In the present study, Nrl, a photoreceptor-specific transcription factor that is highly expressed in photoreceptors at the postnatal stage, did not affect the transcription of mr-s.	factor	0.3125	easy
3M7OI89LVYOS99TV70NIZAWVGOJC6H	biomed	BMP activity also plays an indirect role in limb patterning as a key component of a feedback loop between SHH production in the posterior limb bud and fibroblast growth factor production in the overlying apical ectodermal ridge (AER).	loop	0.1875	very easy
3X2LT8FDHWIORLIOH6KHVIZPEZQ8W7	biomed	SOX9 up-regulates Fgf9, which initiates a Sox9/Fgf9 feed-forward loop that accelerates commitment to the male pathway.	loop	0.265625	easy
3R5LWXWHR08I90TWA9SRPEUUBL1XGZ	biomed	Especially, it is evident in their putative integrin binding loop sequences, CR(E/D)AVN(E/D)CD, which is located centre of the disintegrin domain.	loop	0.347826	easy
3UEDKCTP9VQTW7JOIN98T79ZG947KI	biomed	Patients with the intermediate form of the disease show BCKDH activity in the range of 3–30% of normal.	show	0.1875	very easy
33KGGVH24UHL5L3TSQ7OIRQO9VQX15	biomed	The next two show expression of both the stable wild-type AQP2 and the transient AQP2-F204V-GFP.	show	0.25	easy
3RHLQY6EDT4OZEVVO8PEMIUZ5XJ4DI	biomed	Several studies of this CSS panel, B6 Chr1-19, X, YA/J, have been reported for behavior [12], weight gain [13], sterols [13], and plasma amino acids levels [13,14], and have identified many more QTL than studies of the same traits using a genome-wide scan.	weight	0.1875	very easy
3QD8LUVX4XYKT34CTD90LH35LBR5XR	biomed	However, we observed that the insulin-sensitive phenotype of the female PGC-1α−/− mice occurred in the context of normal weight gain with high-fat diet.	weight	0.197368	very easy
3LB1BGHFL2WBEA5CZ5D07BGS3L4YTG	biomed	RMCE with a p53ΔPGFP replacement plasmid was again very efficient and western blots revealed an additional band of the predicted molecular weight only in p53+/ΔPGFP ES cells (Figure 3B).	weight	0.205882	easy
37M4O367VJI9ZR58F67RA0N7E84M5N	biomed	Patients with MSUD, depending on the mutation, show variable degrees of enzyme deficiency leading to several different clinical phenotypes [1].	degrees	0.190476	very easy
3BS6ERDL9372E1Z97WITJGED1PN6D5	biomed	All of these mutants are cold intolerant and display varying degrees of fatty changes in liver, heart, and kidney.	degrees	0.25	easy
3Y3N5A7N4G971FFSQ8COLXL09D8MY3	biomed	Diabetes insipidus can be defined as an inability to concentrate urine where appropriate.	urine	0.190476	very easy
3FJ2RVH25Z62TA3R8E1O77EBUY8293	biomed	Normally, urine concentration is under the control of the hypothalamus, which, in response to hypovolemia or hypernatremia [21], secretes AVP.	urine	0.267857	easy
3X0EMNLXEPPWIOH0DDHWV2B1W1HVPZ	biomed	Activity levels appeared to follow a relatively normal diurnal cycle, decreasing substantially during the daylight hours.	hours	0.22619	easy
37OPIVELUU3KDJGEJ5IVQ6VXP06AH8	biomed	In an attempt to define whether this variation was a benign polymorphism we analyzed genome-wide SNP data at this locus, produced using the same genotyping chip, from 577 individuals of European descent who were either controls or individuals with an unrelated neurological disorder.	attempt	0.220588	easy
3X2LT8FDHWIORLIOH6KHVIZPEZL8W2	biomed	In one study using CF mice on different genetic backgrounds, a region on mouse chromosome 7 was shown to ameliorate intestinal blockage and the effect was in part due to a calcium-regulated Cl-channel which compensated for loss of CFTR function [16,17].	backgrounds	0.191176	very easy
33EEIIWHK77HI0IFDQWLV71B1WAQVQ	biomed	Analyses of CIA in crosses of the same backgrounds, however, did not identify a linkage to this locus, suggesting that the polymorphism underlying Cia40 differs from the genes associated with diabetes [18].	backgrounds	0.296875	easy
3IYI9285WS04X482RJH78E102UXJCO	biomed	The different timing of lethality in the Capn4 knockouts might also be a consequence of the different genetic backgrounds of the two transgenic lines, which has been observed to influence the phenotype of transgenic mice on a number of occasions [37].	backgrounds	0.296875	easy
3OZ4VAIBEXF0WDE2I0CCY6PPN1DJVN	biomed	Single strains on an HG background were created for each chromosomal region outside of MMU2, while a comprehensive panel of overlapping strains with identical donor regions on both B6 and HG backgrounds were developed for MMU2.	backgrounds	0.316667	easy
338431Z1FLFM4HOIPTZ755H81P9ROK	biomed	Mammalian lung is unique in that it is fully developed, but does not function for gas exchange until at the moment of birth; the majority of structural development and maturation takes place in utero.	majority	0.216667	easy
3TTPFEFXCTKJQH4BTS1JA1TBTGI6HE	biomed	In a gene replacement strategy in which BDNF expression was driven by the NT-3 promoter, vestibular axons rerouted towards ectopic sources of BDNF in the cochlea that normally expressed NT-3 and were not innervated by these axons.	strategy	0.191176	very easy
3ATYLI1PRT256T55HOQY3EVHR9EJOL	biomed	Two annexin A7 129Sv null mice strains were generated independently using a different strategy.	strategy	0.297619	easy
3C8QQOM6JP115XI2MEP6ZWCNJOMILR	biomed	Our data provide strong evidence for at least two branches of cellular anti-cadmium defense, one via MTF-1 and its target genes, notably metallothioneins, the other via glutathione, with an apparent overlap in Sepw1.	defense	0.303571	easy
3GV1I4SEO9PLCDN1KDGH2TMIAXR6LL	biomed	Moreover an inverse relationship between lower dopamine D2R levels and compulsive behavior in human subjects has been reported [22].	subjects	0.191176	very easy
3UEDKCTP9VQTW7JOIN98T79ZG86K7V	biomed	These genes had a higher expression in DBA/1 than in FVB/N at the early phases of CIA (NC, PI and OA) and the opposite expression pattern in the CA phase.	phases	0.386364	easy
3TZ0XG8CBUKDFP5GOVAPHYREGY089C	biomed	Recently, we reported that the helicase and ATP hydrolysis activities of mammalian Mcm4/6/7 are specifically activated by single-stranded DNA containing stretches of thymine residues and proposed a novel model that Mcm may play a crucial role in selection of replication origins in higher eukaryotes (13).	selection	0.191176	very easy
3DWNFENNE3V120VNY4BPPGPCAHG4JW	biomed	In addition, the incompletely penetrant postnatal mortality noted in the PGC-1α−/− mice reported by Lin et al. could have resulted in a selection bias toward greater levels of compensatory responses in liver and other tissues in the surviving group.	selection	0.21875	easy
3EHVO81VN5LOJV3ENMP2F52UL57H1W	biomed	Further, although the polymorphism assessed typically resides within a gene known to protect bronchial epithelium from carcinogens, oxidants, or DNA damage, the selection of the particular polymorphism for study is largely empiric, and not based on known functional properties.	selection	0.266667	easy
3M47JKRKCX1QX63IQO7DXO0CQXS861	biomed	Such large numbers of nonsynonymous substitutions between orthologues is suggestive of adaptive selection.	selection	0.347222	easy
3KG2UQJ0MJO4AV96BZAULQ7YFU1NQ1	biomed	ADAM22 and ADAM23 share highly homologous sequences in their extracellular domains.	share	0.191176	very easy
3BPP3MA3TCKPPSGGQVZFEHEVRVKLEQ	biomed	The aged Sam68−/− females were not obese and actually weighed less than the littermate controls (see Table 2).	Table	0.192308	very easy
3X0EMNLXEPPWIOH0DDHWV2B1W0OPVY	biomed	In contrast, interactions between 2PM/2M QTL and hg primarily affect fat deposition (Table 3).	Table	0.25	easy
3Z3R5YC0P3N5EJOHUFLCIQ9CX9GTFE	biomed	Virtually-multiplexed transcript abundance data were obtained for each gene in each of the 49 samples, except for E2F1 measurement in sample 147 (Table 3).	Table	0.261905	easy
3ULIZ0H1VA5C32JJMKOTQ8Z4GX951Y	biomed	Many of the available inbred mouse strains, such as C57BL/6J (B6) and A/J, have been classified as resistant or susceptible to particular complex diseases (Table 1).	Table	0.265625	easy
3IYI9285WS04X482RJH78E102VVJCO	biomed	For example, the non-BC individual and BC individual groups are not perfectly matched with respect to age, gender or smoking history (Table 1) and each of these factors could contribute to the observed difference in correlation between groups.	Table	0.3125	easy
3Y7LTZE0YTMQJDU6VW5TQEBWSSHUZU	biomed	Their biological activities implicate ADAMs in fertilization, myogenesis and neurogenesis by proteolysis and adhesion.	fertilization	0.194444	very easy
3EQVJH0T40LPSFFNP59CLBLPDOTTHC	biomed	m-calpain also relocalized to the oocyte meiotic spindle after fertilization, were it could be involved in chromosome segregation [45].	fertilization	0.21875	easy
32FESTC2NHQDBKJW3ILLFGABJBTUCV	biomed	We focused on one of the four lines, line 107, to examine in more detail the time dependence and extent of transgene suppression following either acute or chronic treatment with dox.	detail	0.25	easy
3BC9H1KCYUC36R96UAIBUVNR7ETWY9	biomed	However, mice on the mixed background seemed more robust than CF mice on the B6 background which prompted us to characterize them in greater detail.	detail	0.297619	easy
3D7VY91L65XBO7MHGGY4DMNZO3SBMD	biomed	The primitive wave of hematopoiesis produces a burst of embryonic erythrocytes and macrophages.	burst	0.194444	very easy
3J5XXLQDHMBPBZCDFFKPIZ80R4RV3N	biomed	The exact in vivo molecular mechanisms, by which alpha-crystallin might influence lens epithelial cell differentiation, and maintenance of lens transparency, remain to be determined.	transparency	0.194444	very easy
33NKDW9FFXI5SODR8NW8ZN9FDSBXCP	biomed	Animals use the gustatory system to provide information about food quality.	Animals	0.194444	very easy
3W5PY7V3UP7H0797NBZW55TJ5IKYJG	biomed	Based on the theory that Sertoli cells initiate all downstream testicular differentiation, this might imply that Sertoli differentiation had been initiated in Wnt4 -/- XX gonads.	theory	0.194444	very easy
3J6BHNX0U9SIZSBBYUQXP4VPGNBNK9	biomed	In this study, the lack of evidence of abnormal lung branching morphogenesis in the early stages, but a consistent delayed maturation of the gas-exchange region of the lung in the saccular period of development of Dhcr7-/- embryos was observed, suggesting early Shh signaling was normal.	development	0.194444	very easy
3QE4DGPGBRBRBY5MQYQMS3XWIP4G49	biomed	Our findings reveal a role for CAF-1 in the nuclear organization of heterochromatin domains during early development and in ES cells.	development	0.25	easy
3D0LPO3EABZV1I043OR1D1A54DNOYK	biomed	Since LCA is a clinically and genetically heterogeneous disorder, additional mouse models are in order to allow a full understanding of the many ways in which photoreceptor development can go awry.	development	0.364583	easy
3909MD9T2ZH3P06K4KWHJ49BUZYEFE	biomed	The endocochlear potential and the endolymphatic and perilymphatic K+ concentrations were measured in young adult mice (1–4 month of age) that either have (Slc26a4+/+) or lack (Slc26a4-/-) a functional gene for pendrin [14].	month	0.195652	very easy
3XH7ZM9YX2UJXUKCN4GP8FMJ6QO9RP	biomed	Crosses between wild-type and heterozygous mice also produced progeny with a greater than expected proportion of heterozygous offspring.	proportion	0.196429	very easy
3NQUW096N688UWPZIKJTM3DK0Y59L5	biomed	Epidemiologic assessment of the correlation between a particular variation in DNA sequence, or polymorphism, and risk for BC has been a dominant paradigm for many years.	correlation	0.196429	very easy
3KWGG5KP6J2UYCENUGUZO6TH6OSMCV	biomed	In humans, risk for emphysema is associated with antioxidant capacity [23], and there is a strong correlation between risk for emphysema and risk for BC.	correlation	0.2	easy
3LOJFQ4BOXF9DGKY90CUTZJV2JEDKM	biomed	The correlation of transcript abundance values for CEBPG relative to transcript abundance values for each of the antioxidant or DNA repair genes will be assessed.	correlation	0.339286	easy
32CAVSKPCEPTOH9YNLW1YKRKFD9U1A	biomed	The maintained correlation of E2F1 with DNA repair and antioxidant genes in BC individuals suggests that this function is more tightly controlled in the population and does not play a role in determination of risk for BC.	correlation	0.546875	neutral
39XCQ6V3KY47AOKGSQ0AL4QLO7R65X	biomed	Crx, a downstream target of Otx2, controls the transcription of various photoreceptor cell-specific genes and is essential for the formation of outer segments, synaptic terminals, and phototransduction pathways [8,10].	segments	0.196429	very easy
306996CF6WKESI0SNUF6TUZWQTW1BW	biomed	The sequence of this large protein (3418 amino acids) offers very little clue to its function, although there are eight repeated segments (termed BRC repeats) in the middle of the protein that are highly conserved among mammalian orthologs [7,8].	segments	0.308824	easy
3UUIU9GZC55DCMVSO383WEIZ8F7T50	biomed	Loss of function mutations in rhodopsin [29], or the structural protein, peripherin [30], result in an inability to form outer segments.	segments	0.323529	easy
362E9TQF2HQLJ541BNSQM47FN8YIGL	biomed	They see no proprioceptive afferents in the periphery of the double knockouts and note that central proprioceptive afferents terminate in the intermediate spinal cord without extending ventrally.	cord	0.196429	very easy
3OREP8RUT2BBWXQV5D090H32SIEGBA	biomed	It appears that peripheral NT-3 alone is sufficient for rescuing proprioceptive neurons in NT-3 KO animals and proper axonal pathfinding in the spinal cord.	cord	0.235294	easy
3MDWE879UH2WHN3NR7UZ80HFO4R9BI	biomed	A simple bud-like structure initiates the formation of many organs, including lungs, spinal cord, mammary glands, and hair follicles [1].	cord	0.25	easy
3L55D8AUFAXUST31DJIAI1GOFY6YCX	biomed	However, NT-3 may not be the only molecule that plays a role in targeting and terminal branching of sensory axons in the ventral spinal cord.	cord	0.25	easy
3LB1BGHFL2WBEA5CZ5D07BGS3KBYTL	biomed	Studies in embryonic mice reported NT-3 mRNA in the ventral horns of the spinal cord, but it is not definitive that both mRNA and protein are expressed solely by motor neurons.	cord	0.304348	easy
3OQQD2WO8I6KPTSDG8L63AI6J21I3J	biomed	Therefore it should be possible to use flow cytometry to isolate cells expressing either or both of the reporters from embryos or adult organs [14].	flow	0.196429	very easy
3FO95NVK5C0129GBWAGGPAR9YEISRO	biomed	A recent study [25] of sheer stress in rats, found that the magnitude of changes in sheer stress with increased blood flow varied with the different strains.	flow	0.323529	easy
3IKMEYR0LWVMA6MICBSDXGSR5SQ2K3	biomed	One criticism of the speed congenic approach is the potential for QTL to reside among unwanted donor alleles not eliminated during backcrossing.	potential	0.196429	very easy
3S4TINXCC0NZOA7TTWDH5QC4J45BOS	biomed	These observations make it unlikely that the primary cause of the loss of the endocochlear potential is a compromise of K+ secretion by strial marginal cells or a compromise of gap junction mediated K+ cycling.	potential	0.25	easy
3WRAAIUSBJZHZ9GTO90HTSJRDPQXAN	biomed	The endocochlear potential and the endolymphatic and perilymphatic K+ concentrations were measured in young adult mice (1-4 month of age) that either have (Slc26a4+/+) or lack (Slc26a4-/-) a functional gene for pendrin [14].	potential	0.25	easy
3G4VVJO6PZGI2DNOE93PTT0KG3APK7	biomed	The human gene MCOLN1 (GenBank #AF287270) maps to chromosome 19p13.2-13.3 and encodes a novel protein that is a member of the transient receptor potential (TRP) cation channel gene superfamily [7-10].	potential	0.259615	easy
3SX4X51T809U5021NIDLAFSY1LMOAA	biomed	Degeneration of hair cells is probably a response to the loss of the endocochlear potential.	potential	0.261905	easy
37SOB9Z0SSXMFU0J1BIJVQAY06Q3LD	biomed	Mice have great potential for helping to characterize the molecular mechanisms affecting IOP.	Mice	0.196429	very easy
3HEM8MA6H9C4DGLJRENMPFCTF89QP5	biomed	Mice homozygous for a null mutation in Fgf9 display male-to-female sex reversal caused by disruption of all testis-specific cellular events, including cell proliferation, mesonephric cell migration, testis cord formation, and the differentiation of Sertoli cells [ 26, 27].	Mice	0.367647	easy
366FYU4PTGPE5MYY5VNEZH1G2VFKEM	biomed	A possible explanation for this discrepancy may lie in the fact that the Apcs−/− mice analysed in the original study were generated from a limited number of founders and that this may have caused a nonrandom inheritance of the loci from the parental strains.	inheritance	0.421053	neutral
30EMX9PEVKJFF53G6Q7JOY5V3MOSKV	biomed	It has been previously shown that MTF-1 is important for both basal expression and metal induction of the mouse Znt1 gene (19).	metal	0.196429	very easy
3UEBBGULPFOKEW36UKBMNMVEGNMUF5	biomed	Interestingly, Bauer and colleagues previously identified a locus (Cia28) associated with anti-CII antibody production at 53 cM on chromosome 13 [19], which is approximately at the same position as where we find the linkage for this trait in the present study.	colleagues	0.279412	easy
3UQ1LLR26A8MZFZ4AQXTIYO46GHLAQ	biomed	Pendred syndrome is a relatively common autosomal-recessive disorder characterized by deafness and goiter [1].	disorder	0.203125	easy
3RIHDBQ1NEYLFKP3G880ZXQXJG3HM5	biomed	Smith-Lemli-Opitz syndrome (SLOS, MIM 270400), a relative common dysmorphology disorder, is caused by mutations in DHCR7 [2-5], which encodes for 7-dehydrocholesterol Δ7-reductase and catalyzes a final step of cholesterol biosynthesis.	disorder	0.216667	easy
366FYU4PTGPE5MYY5VNEZH1G2W8KEH	biomed	Clearly, the identification of distinct ITPR1 mutations underlying SCA15 will help elucidate the pathogenic mechanism of this disorder.	disorder	0.265625	easy
3UY4PIS8QRLGTRPPQKKFKPZQ7HBN16	biomed	Breeding experiments suggested that the observed disorder was inherited in an autosomal recessive manner.	disorder	0.352941	easy
3EKZL9T8Y8M86YDC3JEMW1LLP3RHCH	biomed	Although considerable efforts have been made to identify the genes responsible for the development of the disease, with the exception of the lpr mutation, none of the genetic contributions to disease in the three well-documented murine SLE strains have yet been fully resolved at the molecular or protein level.	efforts	0.197368	very easy
3KG2UQJ0MJO4AV96BZAULQ7YFT8QN9	biomed	Thus far, these efforts have met with scant success [26].	efforts	0.264706	easy
3JUDR1D0D6R8L9KDPGCAT2404YHQ2I	biomed	Interestingly, AVPR2-deficient male pups also die within the first week after birth.	week	0.197368	very easy
3T2HW4QDUV7FRSVT57QUJKNX6PL9CJ	biomed	More generally, they suggest that temporally regulated activation of transcriptional programs coupled to a particular fate induced in neurons at early developmental stages represents an important mechanism of neuronal maturation.	activation	0.2	easy
3ODOP6T3ASK1W4XFRJ5XQZ3V86U429	biomed	This finding reinforces the notion that without continued stimulation, microglia in mouse models do not maintain the same level of sustained activation that may occur in humans.	activation	0.203125	easy
3RDTX9JRTY19FB0XEQIJ3YVJ5EU79O	biomed	Recent studies in a variety of experiment systems suggest that such a stochastic, all-or-none mechanism of gene activation is commonplace [38–44].	activation	0.361111	easy
3I4E7AFQ2KZLJLADD5CXXO14QG2JTC	biomed	Stress proteins have been shown to be expressed in non-stressed cells during development and differentiation [25].	Stress	0.2	easy
3Y40HMYLL1I1EIURUEH8TTVLKSJUXX	biomed	It also plays a crucial role in the initiation step at the replication origins.	initiation	0.2	easy
3SNR5F7R92TNZR8A5S22M1M3ASJEI0	biomed	Studies are currently underway to identify the causative mutation and to characterize the effects of age and diet on obesity in this strain as well as testing for other physiological consequences such as alterations in food intake and insulin sensitivity.	diet	0.2	easy
37ZQELHEQ0YDPGBEJ63D4HNT5S6MND	biomed	The best-studied strains of mice that spontaneously develop a lupus-like pathology are the New Zealand Black/New Zealand White hybrid strain (NZB/WF1); the MRL/Mp lpr/lpr strain, which carries the lpr mutation of the FAS receptor gene; and the BXSB strain, which carries the Y chromosome autoimmune accelerator (Yaa) gene (Theofilopoulos and Dixon 1985).	White	0.269231	easy
3MNJFORX8B43THDRTJ3EFA3YH6U5FZ	biomed	Defects in recombination can preclude homologous chromosome pairing, leave unrepaired chromosome breaks, and cause aneuploidy by abrogating crossing over.	Defects	0.2	easy
31D0ZWOD0AZ92JAILXBAKEWG3J40AW	biomed	To ensure that the transgene could be suppressed as rapidly in 6-mo-old mice with fulminant pathology as it can in young, predeposit animals, we treated an additional set of 6-mo-old animals with dox for 1 wk prior to harvest.	harvest	0.3	easy
3NBFJK3IOHIVFRF49I5V6131ZG4OGR	biomed	Consistent with the filter trap results presented above, there were no significant differences in SDS- or FA-soluble Aβ between the 6 mo untreated cohort and either the 6 mo + 3 mo treated or 6 mo + 6 mo treated cohorts.	cohorts	0.2	easy
3B6F54KMR2CD94HUYG11JJ9WUGJ1SW	biomed	Consistent with the filter trap results presented above, there were no significant differences in SDS- or FA-soluble Aβ between the 6 mo untreated cohort and either the 6 mo + 3 mo treated or 6 mo + 6 mo treated cohorts.	cohorts	0.4375	neutral
3WGCNLZJKF877FYC1Q6COKNWTE81D3	biomed	In fact, levels of PBS-soluble Aβ40 and Aβ42 in the 6 mo + 3 mo and 6 mo + 6 mo treated cohorts were most similar to that of the 9 mo untreated cohort, suggesting that age, as opposed to synthetic rate (which would be negligible in the treated animals), may determine the fraction of PBS-soluble Aβ in these animals.	cohorts	0.446429	neutral
3QXFBUZ4ZKGQSWZ154H457VQH2NGUR	biomed	For the loci whose counterparts on the human genome are linked to RA, we will investigate the candidate genes using case-control association studies in RA cohorts.	cohorts	0.472222	neutral
3ZG552ORAM40QHGUBF6KZP38LQWV2H	biomed	Support for the hypothesis that the observed mislocalization of RAD51 is an indirect consequence of the BRCA2 defect requires reintroduction of functional BRCA2 into CAPAN-1.	Support	0.2	easy
3WYZV0QBFJDMIJLLUN0DO33XV7BXBI	biomed	The results confirm that deleting the proline rich domain leads to less active p53 with impaired cell cycle control, and also indicate that a GFP C-terminal fusion can dramatically alter p53 regulation.	cycle	0.2	easy

3EN4YVUOUCSS02JXIFDUMRMA3CLXJ4

biomed

The cross consists of 334 animals of both sexes, allowing us to specifically test for the dependence of QTLs on sex.

dependence

0.1875

very easy

3BS6ERDL9372E1Z97WITJGED1OP6D5

biomed

We focused on one of the four lines, line 107, to examine in more detail the time dependence and extent of transgene suppression following either acute or chronic treatment with dox.

dependence

0.220588

easy

3N3WJQXELSQXUC40XB4ECG56USV2L6

biomed

The fusion of EWS with Pea3 could circumvent a need for activation through specific cofactors while still maintaining ETS site dependence, thus rendering EWS-Pea3 less sensitive to the cellular context than endogenous ETS transcription factors.

dependence

0.411765

neutral

3X878VYTIEIIGLRAHCIBDUHU8CV7FM

biomed

To our knowledge, this has not been directly described for any other transcriptional factor.

factor

0.1875

very easy

3UQ1LLR26A8MZFZ4AQXTIYO46GMALK

biomed

With this reference point, we then designed experiments to examine the effects of precocious post-mitotic expression of the same ETS transcription factor on sensory neuron differentiation.

factor

0.194444

very easy

33KGGVH24UHL5L3TSQ7OIRQO9VKX1Z

biomed

Among histone chaperones, chromatin assembly factor 1 (CAF-1) is a three-subunit (p150, p60, and p48) complex which promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair [9,10].

factor

0.267857

easy

3V0TR1NRVA2Q17SJ4YYCWHMTKUM4AG

biomed

In the present study, Nrl, a photoreceptor-specific transcription factor that is highly expressed in photoreceptors at the postnatal stage, did not affect the transcription of mr-s.

factor

0.3125

easy

3M7OI89LVYOS99TV70NIZAWVGOJC6H

biomed

BMP activity also plays an indirect role in limb patterning as a key component of a feedback loop between SHH production in the posterior limb bud and fibroblast growth factor production in the overlying apical ectodermal ridge (AER).

loop

0.1875

very easy

3X2LT8FDHWIORLIOH6KHVIZPEZQ8W7

biomed

SOX9 up-regulates Fgf9, which initiates a Sox9/Fgf9 feed-forward loop that accelerates commitment to the male pathway.

loop

0.265625

easy

3R5LWXWHR08I90TWA9SRPEUUBL1XGZ

biomed

Especially, it is evident in their putative integrin binding loop sequences, CR(E/D)AVN(E/D)CD, which is located centre of the disintegrin domain.

loop

0.347826

easy

3UEDKCTP9VQTW7JOIN98T79ZG947KI

biomed

Patients with the intermediate form of the disease show BCKDH activity in the range of 3–30% of normal.

show

0.1875

very easy

33KGGVH24UHL5L3TSQ7OIRQO9VQX15

biomed

The next two show expression of both the stable wild-type AQP2 and the transient AQP2-F204V-GFP.

show

0.25

easy

3RHLQY6EDT4OZEVVO8PEMIUZ5XJ4DI

biomed

Several studies of this CSS panel, B6 Chr1-19, X, YA/J, have been reported for behavior [12], weight gain [13], sterols [13], and plasma amino acids levels [13,14], and have identified many more QTL than studies of the same traits using a genome-wide scan.

weight

0.1875

very easy

3QD8LUVX4XYKT34CTD90LH35LBR5XR

biomed

However, we observed that the insulin-sensitive phenotype of the female PGC-1α−/− mice occurred in the context of normal weight gain with high-fat diet.

weight

0.197368

very easy

3LB1BGHFL2WBEA5CZ5D07BGS3L4YTG

biomed

RMCE with a p53ΔPGFP replacement plasmid was again very efficient and western blots revealed an additional band of the predicted molecular weight only in p53+/ΔPGFP ES cells (Figure 3B).

weight

0.205882

easy

37M4O367VJI9ZR58F67RA0N7E84M5N

biomed

Patients with MSUD, depending on the mutation, show variable degrees of enzyme deficiency leading to several different clinical phenotypes [1].

degrees

0.190476

very easy

3BS6ERDL9372E1Z97WITJGED1PN6D5

biomed

All of these mutants are cold intolerant and display varying degrees of fatty changes in liver, heart, and kidney.

degrees

0.25

easy

3Y3N5A7N4G971FFSQ8COLXL09D8MY3

biomed

Diabetes insipidus can be defined as an inability to concentrate urine where appropriate.

urine

0.190476

very easy

3FJ2RVH25Z62TA3R8E1O77EBUY8293

biomed

Normally, urine concentration is under the control of the hypothalamus, which, in response to hypovolemia or hypernatremia [21], secretes AVP.

urine

0.267857

easy

3X0EMNLXEPPWIOH0DDHWV2B1W1HVPZ

biomed

Activity levels appeared to follow a relatively normal diurnal cycle, decreasing substantially during the daylight hours.

hours

0.22619

easy

37OPIVELUU3KDJGEJ5IVQ6VXP06AH8

biomed

In an attempt to define whether this variation was a benign polymorphism we analyzed genome-wide SNP data at this locus, produced using the same genotyping chip, from 577 individuals of European descent who were either controls or individuals with an unrelated neurological disorder.

attempt

0.220588

easy

3X2LT8FDHWIORLIOH6KHVIZPEZL8W2

biomed

In one study using CF mice on different genetic backgrounds, a region on mouse chromosome 7 was shown to ameliorate intestinal blockage and the effect was in part due to a calcium-regulated Cl-channel which compensated for loss of CFTR function [16,17].

backgrounds

0.191176

very easy

33EEIIWHK77HI0IFDQWLV71B1WAQVQ

biomed

Analyses of CIA in crosses of the same backgrounds, however, did not identify a linkage to this locus, suggesting that the polymorphism underlying Cia40 differs from the genes associated with diabetes [18].

backgrounds

0.296875

easy

3IYI9285WS04X482RJH78E102UXJCO

biomed

The different timing of lethality in the Capn4 knockouts might also be a consequence of the different genetic backgrounds of the two transgenic lines, which has been observed to influence the phenotype of transgenic mice on a number of occasions [37].

backgrounds

0.296875

easy

3OZ4VAIBEXF0WDE2I0CCY6PPN1DJVN

biomed

Single strains on an HG background were created for each chromosomal region outside of MMU2, while a comprehensive panel of overlapping strains with identical donor regions on both B6 and HG backgrounds were developed for MMU2.

backgrounds

0.316667

easy

338431Z1FLFM4HOIPTZ755H81P9ROK

biomed

Mammalian lung is unique in that it is fully developed, but does not function for gas exchange until at the moment of birth; the majority of structural development and maturation takes place in utero.

majority

0.216667

easy

3TTPFEFXCTKJQH4BTS1JA1TBTGI6HE

biomed

In a gene replacement strategy in which BDNF expression was driven by the NT-3 promoter, vestibular axons rerouted towards ectopic sources of BDNF in the cochlea that normally expressed NT-3 and were not innervated by these axons.

strategy

0.191176

very easy

3ATYLI1PRT256T55HOQY3EVHR9EJOL

biomed

Two annexin A7 129Sv null mice strains were generated independently using a different strategy.

strategy

0.297619

easy

3C8QQOM6JP115XI2MEP6ZWCNJOMILR

biomed

Our data provide strong evidence for at least two branches of cellular anti-cadmium defense, one via MTF-1 and its target genes, notably metallothioneins, the other via glutathione, with an apparent overlap in Sepw1.

defense

0.303571

easy

3GV1I4SEO9PLCDN1KDGH2TMIAXR6LL

biomed

Moreover an inverse relationship between lower dopamine D2R levels and compulsive behavior in human subjects has been reported [22].

subjects

0.191176

very easy

3UEDKCTP9VQTW7JOIN98T79ZG86K7V

biomed

These genes had a higher expression in DBA/1 than in FVB/N at the early phases of CIA (NC, PI and OA) and the opposite expression pattern in the CA phase.

phases

0.386364

easy

3TZ0XG8CBUKDFP5GOVAPHYREGY089C

biomed

Recently, we reported that the helicase and ATP hydrolysis activities of mammalian Mcm4/6/7 are specifically activated by single-stranded DNA containing stretches of thymine residues and proposed a novel model that Mcm may play a crucial role in selection of replication origins in higher eukaryotes (13).

selection

0.191176

very easy

3DWNFENNE3V120VNY4BPPGPCAHG4JW

biomed

In addition, the incompletely penetrant postnatal mortality noted in the PGC-1α−/− mice reported by Lin et al. could have resulted in a selection bias toward greater levels of compensatory responses in liver and other tissues in the surviving group.

selection

0.21875

easy

3EHVO81VN5LOJV3ENMP2F52UL57H1W

biomed

Further, although the polymorphism assessed typically resides within a gene known to protect bronchial epithelium from carcinogens, oxidants, or DNA damage, the selection of the particular polymorphism for study is largely empiric, and not based on known functional properties.

selection

0.266667

easy

3M47JKRKCX1QX63IQO7DXO0CQXS861

biomed

Such large numbers of nonsynonymous substitutions between orthologues is suggestive of adaptive selection.

selection

0.347222

easy

3KG2UQJ0MJO4AV96BZAULQ7YFU1NQ1

biomed

ADAM22 and ADAM23 share highly homologous sequences in their extracellular domains.

share

0.191176

very easy

3BPP3MA3TCKPPSGGQVZFEHEVRVKLEQ

biomed

The aged Sam68−/− females were not obese and actually weighed less than the littermate controls (see Table 2).

Table

0.192308

very easy

3X0EMNLXEPPWIOH0DDHWV2B1W0OPVY

biomed

In contrast, interactions between 2PM/2M QTL and hg primarily affect fat deposition (Table 3).

Table

0.25

easy

3Z3R5YC0P3N5EJOHUFLCIQ9CX9GTFE

biomed

Virtually-multiplexed transcript abundance data were obtained for each gene in each of the 49 samples, except for E2F1 measurement in sample 147 (Table 3).

Table

0.261905

easy

3ULIZ0H1VA5C32JJMKOTQ8Z4GX951Y

biomed

Many of the available inbred mouse strains, such as C57BL/6J (B6) and A/J, have been classified as resistant or susceptible to particular complex diseases (Table 1).

Table

0.265625

easy

3IYI9285WS04X482RJH78E102VVJCO

biomed

For example, the non-BC individual and BC individual groups are not perfectly matched with respect to age, gender or smoking history (Table 1) and each of these factors could contribute to the observed difference in correlation between groups.

Table

0.3125

easy

3Y7LTZE0YTMQJDU6VW5TQEBWSSHUZU

biomed

Their biological activities implicate ADAMs in fertilization, myogenesis and neurogenesis by proteolysis and adhesion.

fertilization

0.194444

very easy

3EQVJH0T40LPSFFNP59CLBLPDOTTHC

biomed

m-calpain also relocalized to the oocyte meiotic spindle after fertilization, were it could be involved in chromosome segregation [45].

fertilization

0.21875

easy

32FESTC2NHQDBKJW3ILLFGABJBTUCV

biomed

We focused on one of the four lines, line 107, to examine in more detail the time dependence and extent of transgene suppression following either acute or chronic treatment with dox.

detail

0.25

easy

3BC9H1KCYUC36R96UAIBUVNR7ETWY9

biomed

However, mice on the mixed background seemed more robust than CF mice on the B6 background which prompted us to characterize them in greater detail.

detail

0.297619

easy

3D7VY91L65XBO7MHGGY4DMNZO3SBMD

biomed

The primitive wave of hematopoiesis produces a burst of embryonic erythrocytes and macrophages.

burst

0.194444

very easy

3J5XXLQDHMBPBZCDFFKPIZ80R4RV3N

biomed

The exact in vivo molecular mechanisms, by which alpha-crystallin might influence lens epithelial cell differentiation, and maintenance of lens transparency, remain to be determined.

transparency

0.194444

very easy

33NKDW9FFXI5SODR8NW8ZN9FDSBXCP

biomed

Animals use the gustatory system to provide information about food quality.

Animals

0.194444

very easy

3W5PY7V3UP7H0797NBZW55TJ5IKYJG

biomed

Based on the theory that Sertoli cells initiate all downstream testicular differentiation, this might imply that Sertoli differentiation had been initiated in Wnt4 -/- XX gonads.

theory

0.194444

very easy

3J6BHNX0U9SIZSBBYUQXP4VPGNBNK9

biomed

In this study, the lack of evidence of abnormal lung branching morphogenesis in the early stages, but a consistent delayed maturation of the gas-exchange region of the lung in the saccular period of development of Dhcr7-/- embryos was observed, suggesting early Shh signaling was normal.

development

0.194444

very easy

3QE4DGPGBRBRBY5MQYQMS3XWIP4G49

biomed

Our findings reveal a role for CAF-1 in the nuclear organization of heterochromatin domains during early development and in ES cells.

development

0.25

easy

3D0LPO3EABZV1I043OR1D1A54DNOYK

biomed

Since LCA is a clinically and genetically heterogeneous disorder, additional mouse models are in order to allow a full understanding of the many ways in which photoreceptor development can go awry.

development

0.364583

easy

3909MD9T2ZH3P06K4KWHJ49BUZYEFE

biomed

The endocochlear potential and the endolymphatic and perilymphatic K+ concentrations were measured in young adult mice (1–4 month of age) that either have (Slc26a4+/+) or lack (Slc26a4-/-) a functional gene for pendrin [14].

month

0.195652

very easy

3XH7ZM9YX2UJXUKCN4GP8FMJ6QO9RP

biomed

Crosses between wild-type and heterozygous mice also produced progeny with a greater than expected proportion of heterozygous offspring.

proportion

0.196429

very easy

3NQUW096N688UWPZIKJTM3DK0Y59L5

biomed

Epidemiologic assessment of the correlation between a particular variation in DNA sequence, or polymorphism, and risk for BC has been a dominant paradigm for many years.

correlation

0.196429

very easy

3KWGG5KP6J2UYCENUGUZO6TH6OSMCV

biomed

In humans, risk for emphysema is associated with antioxidant capacity [23], and there is a strong correlation between risk for emphysema and risk for BC.

correlation

0.2

easy

3LOJFQ4BOXF9DGKY90CUTZJV2JEDKM

biomed

The correlation of transcript abundance values for CEBPG relative to transcript abundance values for each of the antioxidant or DNA repair genes will be assessed.

correlation

0.339286

easy

32CAVSKPCEPTOH9YNLW1YKRKFD9U1A

biomed

The maintained correlation of E2F1 with DNA repair and antioxidant genes in BC individuals suggests that this function is more tightly controlled in the population and does not play a role in determination of risk for BC.

correlation

0.546875

neutral

39XCQ6V3KY47AOKGSQ0AL4QLO7R65X

biomed

Crx, a downstream target of Otx2, controls the transcription of various photoreceptor cell-specific genes and is essential for the formation of outer segments, synaptic terminals, and phototransduction pathways [8,10].

segments

0.196429

very easy

306996CF6WKESI0SNUF6TUZWQTW1BW

biomed

The sequence of this large protein (3418 amino acids) offers very little clue to its function, although there are eight repeated segments (termed BRC repeats) in the middle of the protein that are highly conserved among mammalian orthologs [7,8].

segments

0.308824

easy

3UUIU9GZC55DCMVSO383WEIZ8F7T50

biomed

Loss of function mutations in rhodopsin [29], or the structural protein, peripherin [30], result in an inability to form outer segments.

segments

0.323529

easy

362E9TQF2HQLJ541BNSQM47FN8YIGL

biomed

They see no proprioceptive afferents in the periphery of the double knockouts and note that central proprioceptive afferents terminate in the intermediate spinal cord without extending ventrally.

cord

0.196429

very easy

3OREP8RUT2BBWXQV5D090H32SIEGBA

biomed

It appears that peripheral NT-3 alone is sufficient for rescuing proprioceptive neurons in NT-3 KO animals and proper axonal pathfinding in the spinal cord.

cord

0.235294

easy

3MDWE879UH2WHN3NR7UZ80HFO4R9BI

biomed

A simple bud-like structure initiates the formation of many organs, including lungs, spinal cord, mammary glands, and hair follicles [1].

cord

0.25

easy

3L55D8AUFAXUST31DJIAI1GOFY6YCX

biomed

However, NT-3 may not be the only molecule that plays a role in targeting and terminal branching of sensory axons in the ventral spinal cord.

cord

0.25

easy

3LB1BGHFL2WBEA5CZ5D07BGS3KBYTL

biomed

Studies in embryonic mice reported NT-3 mRNA in the ventral horns of the spinal cord, but it is not definitive that both mRNA and protein are expressed solely by motor neurons.

cord

0.304348

easy

3OQQD2WO8I6KPTSDG8L63AI6J21I3J

biomed

Therefore it should be possible to use flow cytometry to isolate cells expressing either or both of the reporters from embryos or adult organs [14].

flow

0.196429

very easy

3FO95NVK5C0129GBWAGGPAR9YEISRO

biomed

A recent study [25] of sheer stress in rats, found that the magnitude of changes in sheer stress with increased blood flow varied with the different strains.

flow

0.323529

easy

3IKMEYR0LWVMA6MICBSDXGSR5SQ2K3

biomed

One criticism of the speed congenic approach is the potential for QTL to reside among unwanted donor alleles not eliminated during backcrossing.

potential

0.196429

very easy

3S4TINXCC0NZOA7TTWDH5QC4J45BOS

biomed

These observations make it unlikely that the primary cause of the loss of the endocochlear potential is a compromise of K+ secretion by strial marginal cells or a compromise of gap junction mediated K+ cycling.

potential

0.25

easy

3WRAAIUSBJZHZ9GTO90HTSJRDPQXAN

biomed

The endocochlear potential and the endolymphatic and perilymphatic K+ concentrations were measured in young adult mice (1-4 month of age) that either have (Slc26a4+/+) or lack (Slc26a4-/-) a functional gene for pendrin [14].

potential

0.25

easy

3G4VVJO6PZGI2DNOE93PTT0KG3APK7

biomed

The human gene MCOLN1 (GenBank #AF287270) maps to chromosome 19p13.2-13.3 and encodes a novel protein that is a member of the transient receptor potential (TRP) cation channel gene superfamily [7-10].

potential

0.259615

easy

3SX4X51T809U5021NIDLAFSY1LMOAA

biomed

Degeneration of hair cells is probably a response to the loss of the endocochlear potential.

potential

0.261905

easy

37SOB9Z0SSXMFU0J1BIJVQAY06Q3LD

biomed

Mice have great potential for helping to characterize the molecular mechanisms affecting IOP.

Mice

0.196429

very easy

3HEM8MA6H9C4DGLJRENMPFCTF89QP5

biomed

Mice homozygous for a null mutation in Fgf9 display male-to-female sex reversal caused by disruption of all testis-specific cellular events, including cell proliferation, mesonephric cell migration, testis cord formation, and the differentiation of Sertoli cells [ 26, 27].

Mice

0.367647

easy

366FYU4PTGPE5MYY5VNEZH1G2VFKEM

biomed

A possible explanation for this discrepancy may lie in the fact that the Apcs−/− mice analysed in the original study were generated from a limited number of founders and that this may have caused a nonrandom inheritance of the loci from the parental strains.

inheritance

0.421053

neutral

30EMX9PEVKJFF53G6Q7JOY5V3MOSKV

biomed

It has been previously shown that MTF-1 is important for both basal expression and metal induction of the mouse Znt1 gene (19).

metal

0.196429

very easy

3UEBBGULPFOKEW36UKBMNMVEGNMUF5

biomed

Interestingly, Bauer and colleagues previously identified a locus (Cia28) associated with anti-CII antibody production at 53 cM on chromosome 13 [19], which is approximately at the same position as where we find the linkage for this trait in the present study.

colleagues

0.279412

easy

3UQ1LLR26A8MZFZ4AQXTIYO46GHLAQ

biomed

Pendred syndrome is a relatively common autosomal-recessive disorder characterized by deafness and goiter [1].

disorder

0.203125

easy

3RIHDBQ1NEYLFKP3G880ZXQXJG3HM5

biomed

Smith-Lemli-Opitz syndrome (SLOS, MIM 270400), a relative common dysmorphology disorder, is caused by mutations in DHCR7 [2-5], which encodes for 7-dehydrocholesterol Δ7-reductase and catalyzes a final step of cholesterol biosynthesis.

disorder

0.216667

easy

366FYU4PTGPE5MYY5VNEZH1G2W8KEH

biomed

Clearly, the identification of distinct ITPR1 mutations underlying SCA15 will help elucidate the pathogenic mechanism of this disorder.

disorder

0.265625

easy

3UY4PIS8QRLGTRPPQKKFKPZQ7HBN16

biomed

Breeding experiments suggested that the observed disorder was inherited in an autosomal recessive manner.

disorder

0.352941

easy

3EKZL9T8Y8M86YDC3JEMW1LLP3RHCH

biomed

Although considerable efforts have been made to identify the genes responsible for the development of the disease, with the exception of the lpr mutation, none of the genetic contributions to disease in the three well-documented murine SLE strains have yet been fully resolved at the molecular or protein level.

efforts

0.197368

very easy

3KG2UQJ0MJO4AV96BZAULQ7YFT8QN9

biomed

Thus far, these efforts have met with scant success [26].

efforts

0.264706

easy

3JUDR1D0D6R8L9KDPGCAT2404YHQ2I

biomed

Interestingly, AVPR2-deficient male pups also die within the first week after birth.

week

0.197368

very easy

3T2HW4QDUV7FRSVT57QUJKNX6PL9CJ

biomed

More generally, they suggest that temporally regulated activation of transcriptional programs coupled to a particular fate induced in neurons at early developmental stages represents an important mechanism of neuronal maturation.

activation

0.2

easy

3ODOP6T3ASK1W4XFRJ5XQZ3V86U429

biomed

This finding reinforces the notion that without continued stimulation, microglia in mouse models do not maintain the same level of sustained activation that may occur in humans.

activation

0.203125

easy

3RDTX9JRTY19FB0XEQIJ3YVJ5EU79O

biomed

Recent studies in a variety of experiment systems suggest that such a stochastic, all-or-none mechanism of gene activation is commonplace [38–44].

activation

0.361111

easy

3I4E7AFQ2KZLJLADD5CXXO14QG2JTC

biomed

Stress proteins have been shown to be expressed in non-stressed cells during development and differentiation [25].

Stress

0.2

easy

3Y40HMYLL1I1EIURUEH8TTVLKSJUXX

biomed

It also plays a crucial role in the initiation step at the replication origins.

initiation

0.2

easy

3SNR5F7R92TNZR8A5S22M1M3ASJEI0

biomed

Studies are currently underway to identify the causative mutation and to characterize the effects of age and diet on obesity in this strain as well as testing for other physiological consequences such as alterations in food intake and insulin sensitivity.

diet

0.2

easy

37ZQELHEQ0YDPGBEJ63D4HNT5S6MND

biomed

The best-studied strains of mice that spontaneously develop a lupus-like pathology are the New Zealand Black/New Zealand White hybrid strain (NZB/WF1); the MRL/Mp lpr/lpr strain, which carries the lpr mutation of the FAS receptor gene; and the BXSB strain, which carries the Y chromosome autoimmune accelerator (Yaa) gene (Theofilopoulos and Dixon 1985).

White

0.269231

easy

3MNJFORX8B43THDRTJ3EFA3YH6U5FZ

biomed

Defects in recombination can preclude homologous chromosome pairing, leave unrepaired chromosome breaks, and cause aneuploidy by abrogating crossing over.

Defects

0.2

easy

31D0ZWOD0AZ92JAILXBAKEWG3J40AW

biomed

To ensure that the transgene could be suppressed as rapidly in 6-mo-old mice with fulminant pathology as it can in young, predeposit animals, we treated an additional set of 6-mo-old animals with dox for 1 wk prior to harvest.

harvest

0.3

easy

3NBFJK3IOHIVFRF49I5V6131ZG4OGR

biomed

Consistent with the filter trap results presented above, there were no significant differences in SDS- or FA-soluble Aβ between the 6 mo untreated cohort and either the 6 mo + 3 mo treated or 6 mo + 6 mo treated cohorts.

cohorts

0.2

easy

3B6F54KMR2CD94HUYG11JJ9WUGJ1SW

biomed

Consistent with the filter trap results presented above, there were no significant differences in SDS- or FA-soluble Aβ between the 6 mo untreated cohort and either the 6 mo + 3 mo treated or 6 mo + 6 mo treated cohorts.

cohorts

0.4375

neutral

3WGCNLZJKF877FYC1Q6COKNWTE81D3

biomed

In fact, levels of PBS-soluble Aβ40 and Aβ42 in the 6 mo + 3 mo and 6 mo + 6 mo treated cohorts were most similar to that of the 9 mo untreated cohort, suggesting that age, as opposed to synthetic rate (which would be negligible in the treated animals), may determine the fraction of PBS-soluble Aβ in these animals.

cohorts

0.446429

neutral

3QXFBUZ4ZKGQSWZ154H457VQH2NGUR

biomed

For the loci whose counterparts on the human genome are linked to RA, we will investigate the candidate genes using case-control association studies in RA cohorts.

cohorts

0.472222

neutral

3ZG552ORAM40QHGUBF6KZP38LQWV2H

biomed

Support for the hypothesis that the observed mislocalization of RAD51 is an indirect consequence of the BRCA2 defect requires reintroduction of functional BRCA2 into CAPAN-1.

Support

0.2

easy

3WYZV0QBFJDMIJLLUN0DO33XV7BXBI

biomed

The results confirm that deleting the proline rich domain leads to less active p53 with impaired cell cycle control, and also indicate that a GFP C-terminal fusion can dramatically alter p53 regulation.

cycle

0.2

easy