id stringlengths 30 30 | corpus stringclasses 3 values | sentence stringlengths 10 1.38k | token stringlengths 1 16 ⌀ | complexity float64 0 0.86 | difficulty stringclasses 5 values |
|---|---|---|---|---|---|
3SA4EMRVJV2GPNGKAGT7A9LB2470PD | biomed | Besides the classic form, there are other variants of the disease. | variants | 0.285714 | easy |
3X52SWXE0X5Q3O81YI0MX4V84R4CWC | biomed | MOG, myelin/oligodendrocyte glycoprotein, has many different splice variants in humans that are not found in mice [17]. | variants | 0.357143 | easy |
30QQTY5GMKK7Z3O0C1DAZUIXIZA7UL | biomed | From these observations we conclude that the blue-shifted ECFP, and the red-shifted EYFP variants of wtGFP are both amenable to use in mice. | variants | 0.397059 | easy |
39O6Z4JLX2X1RXJRZ4RDPFX4YZXVXS | biomed | For example, ADAM17 (TACE) has been shown to cleave several substrates, including tumour necrosis factor alpha[3,4], heparin-binding epidermal growth factor-like growth factor [6,7] and transforming growth factor alpha [8]. | tumour | 0.25 | easy |
3M47JKRKCX1QX63IQO7DXO0CQYQ861 | biomed | Mapk14, a candidate gene for locus 8 and also called p38 mitogen-activated protein kinase (MAPK) alpha, regulates the production of arthritis-essential cytokines, such as tumour necrosis factor and interleukin-1 [32]. | tumour | 0.428571 | neutral |
3DIIW4IV8PV57PBHGMQPDFACX2R4IK | biomed | Gradients of Pax6 expression are important for determining positional characteristics in the retina [18] and the neocortex [7]. | characteristics | 0.25 | easy |
33QQ60S6ASITHSOGR2S1KF8AALXU01 | biomed | Assuming that CSRP1 is important for the organization of cytoskeletal elements in the mouse, its upregulation by cadmium might protect the organism from damage of the cytoskeleton. | elements | 0.25 | easy |
3TFJJUELSHP4R8AUKYBF9XFJ0JHC20 | biomed | The cross consists of 334 animals of both sexes, allowing us to specifically test for the dependence of QTLs on sex. | cross | 0.25 | easy |
3QI9WAYOGQB8GQIR4MDIEF0D2R4S6Q | biomed | Since the parental strains differ in susceptibility to CIA, in spite of both having the MHC class II A beta genes [15], we wanted to test the susceptibility to inflammatory disease in mice from this cross. | cross | 0.265625 | easy |
3LXX8KJXPW9G0HSWVCZLEKHEV34O9V | biomed | More importantly, we have knowledge of all large previously detected growth and obesity QTL in the current cross [24]. | cross | 0.35 | easy |
3L1EFR8WWT5MU4F3W9GVRQ8033BF90 | biomed | The sequence of DsRed1 has recently been modified and optimized for high levels of expression in mammalian cells by the introduction of 144 silent base pair changes corresponding to human codon usage preferences. | usage | 0.25 | easy |
3PA41K45VN4U7YG4VFEGPOVYAII7PP | biomed | We find that the majority of the olfactory receptors, like most non-olfactory receptor genes [38,39], are transcribed as multiple isoforms, involving alternative splicing of 5' untranslated exons and alternate polyadenylation-site usage. | usage | 0.382353 | easy |
3LOJFQ4BOXF9DGKY90CUTZJV2J9DKH | biomed | However, earlier findings of normal proprioceptive afferent trajectories in chicken embryos despite injection of function-blocking NT-3 antibody into the spinal cord (Oakley et al. 1995) led them to discount this possibility. | chicken | 0.25 | easy |
341YLJU21IZV4BWUC871K0DEDO1I28 | biomed | Amip3 mutants confer resistant to copper toxicity. | toxicity | 0.25 | easy |
308KJXFUJR6AIS79JZZK4PYL0T3ATI | biomed | Altogether, the results suggest that RMCE can give rise to p53GFP-expressing MEFs, but they die rapidly owing to p53GFP toxicity. | toxicity | 0.375 | easy |
3511RHPADVEEYWLLC1JFDODE6KARL9 | biomed | Hence, either GluR-B deficiency, or the expression of Q/R site-unedited GluR-B with a glutamine residue at the critical channel site, leads to increased Ca2+ permeability of AMPA channels, as amply demonstrated in gene-targeted mice [51,53,58,60]. | expression | 0.25 | easy |
3PKVGQTFIHKYYVSKVG857WFAF07YR3 | biomed | Several groups, including ours, have reported the advantage of combining traditional genetics with genome-wide gene expression analysis for the dissection of complex traits. | expression | 0.285714 | easy |
3XEIP58NL0NN0N7CMIDSZRFDF2MLZR | biomed | Wnt14 is expressed in stripes at the sites where joints will form, and it is capable of inducing expression of other joint markers when misexpressed at new locations in the limb (Hartmann and Tabin 2001). | expression | 0.3 | easy |
3WPCIUYH1A88GZAL39QMUQ6RLW5TD8 | biomed | Oxidative stress and the subsequent restoration of cellular homeostasis have been shown to induce the expression of genes encoding acute-phase proteins and antioxidant enzymes (74). | expression | 0.346154 | easy |
3DGDV62G7O9NLXJYP3XLTXEQZ3O2PY | biomed | Mammals have seven DM domain genes (Dmrt genes), several of which exhibit sexually dimorphic mRNA expression [23,24]. | expression | 0.385417 | easy |
37PGLWGSJT6QLR0K1ED5KWZ8UOMIKT | biomed | Our findings indicate that huntingtin is required for proper patterning of the epiblast during early embryogenesis, for proper anterior streak and node formation, primitive streak progression, paraxial mesoderm and head fold formation, as well as for the proper restriction of transiently expressed growth and transcription factor genes. | restriction | 0.25 | easy |
3J9UN9O9J3SK3CDMF3ONDDZZT50J0V | biomed | Current management of MSUD patients relies on a strict lifelong dietary restriction of protein or BCAA [1,8]. | restriction | 0.277778 | easy |
388FBO7JZRTDJX0S29ROYCA0E3IYNF | biomed | Sperm binding to the oocyte leads to increased cytoplasmic calcium which triggers the acrosome reaction [46]. | Sperm | 0.25 | easy |
3W0KKJIARR9XWLO7SS1E775URSC8K6 | biomed | The two ubiquitous Ca2+-dependent, cysteine proteases known as μ-calpain (calpain-1) and m-calpain (capain-2), are the founding members of a gene family comprising 13 genes in mammals [1-3]. | founding | 0.25 | easy |
3HYV4299H0WUALWXW6QB9CSP7WE8EM | biomed | Identification of novel modulators and factors of these pathways can be identified by associating the phenotype with a location(s) on a specific chromosome, a quantitative trait locus (QTL). | Identification | 0.25 | easy |
3VEI3XUCZRX4PH0J4TCMU5MYBV4RP2 | biomed | If, as predicted, overproduction of Aβ initiates the cascade of events leading to disease, then therapeutic strategies that lower Aβ levels should either arrest or reverse the progression from peptide to dementia. | overproduction | 0.25 | easy |
3V0TR1NRVA2Q17SJ4YYCWHMTKUS4AM | biomed | Transgenic expression of APPswe/ind and consequent overproduction of Aβ42 cause early-onset amyloid deposition in untreated mice, in which deposits appear as early as 2 mo of age. | overproduction | 0.416667 | neutral |
3TKXBROM5TAVA7U2JTDTJHZVFZHJIQ | biomed | Similarly, mice homozygous for a null mutation in Dmrt1 have severe defects in testis differentiation involving both germ cells and Sertoli cells [31]. | germ | 0.25 | easy |
35ZRNT9RUIYULF3GE3YBN7ESVCSO3E | biomed | Because most Dmrt7 mutant germ cells are eliminated by apoptosis around the time at which we observed sex chromatin defects, a simple model is that the apoptosis is a consequence of the sex chromatin defects. | germ | 0.447368 | neutral |
3EGKVCRQFWSBIOBVZJMF7HA6XDCBY9 | biomed | In spite of dietary intervention, there is significant mortality associated with MSUD and there is a high incidence of mental retardation in survivors [9]. | mortality | 0.25 | easy |
3D1TUISJWI04ON5WVSH7QJ86WFKUI2 | biomed | Mutations in two different ligands in the BMP family, Gdf5 and Gdf6, the Bmpr1b receptor, and in the human Noggin locus (Storm and Kingsley 1996; Gong et al. 1999; Baur et al. 2000; Yi et al. 2000; Settle et al. 2003) also produce defects in joint formation at specific locations in the limbs. | Storm | 0.25 | easy |
3MD8CKRQZZN836XL9G72X90M2WYJRU | biomed | Several members of the bone morphogenetic protein (BMP) family of secreted signaling molecules are also expressed in stripes at sites where joints will form, including those encoded by the genes Gdf5, Gdf6, Gdf7, Bmp2, and Bmp4 (Storm and Kingsley 1996; Wolfman et al. 1997; Francis-West et al. 1999; Settle et al. 2003). | Storm | 0.302083 | easy |
3MQY1YVHS3KLH3IO6YFKYD91IYBB2M | biomed | For example, in a previous study, we carried out a genome screen to identify the quantitative trait loci (QTL) in collagen-induced arthritis (CIA), which is a widely used animal model of RA. | genome | 0.25 | easy |
334ZEL5JX6FY5WOV4IZCVFM4NRYSOF | biomed | Given our interest in human neurological disease we sought to identify any cognate human disorders where linkage had been established to the syntenic region of the human genome, but where no causal mutation had been identified. | genome | 0.394737 | easy |
3DQYSJDTYLBKPMX54E23PB9IY4PEX0 | biomed | By 2005, approximately 20 quantitative trait genes (QTGs) in the mouse genome had been identified [12,13]. | genome | 0.4 | neutral |
3I7KR83SNADXAQ7HXK7S7305BYUK97 | biomed | The ease of manipulating its genome has helped establish the mouse as the premier model organism for mammalian genetic studies. | genome | 0.464286 | neutral |
3Y40HMYLL1I1EIURUEH8TTVLKSJXU0 | biomed | Using DNase I and micrococcal nuclease (MNase) assays, we could not observe any significant difference between control and p150CAF-1-depleted ES cells at the level of bulk genome chromatin or at pericentric repeats (Figure 5). | genome | 0.473684 | neutral |
3A9LA2FRWSEW9WO7UFA9AE6VQKHHXJ | biomed | All paired images (which show the wild-type control on the left and the rd7 mutant retina on the right) are labeled in the lower left-hand corner with the gene symbol followed by the age of the retinas in question (P6, P14, P28, or adult). | adult | 0.25 | easy |
3W1K7D6QSBHBNEL0V5OYLOJ837GBZ0 | biomed | We used this mutant because deleting the proline-rich domain decreases stability and compromises DNA-damage responses in vivo (5). | compromises | 0.25 | easy |
3NRZ1LDP7W6DR8MAEA6ZG8OXKBOZP2 | biomed | Lysosomal and endosomal size and distribution are altered, and mitochondria are abnormally elongated and functionally compromised in sub-confluent homozygous CbCln3Δex7/8 cultures. | cultures | 0.25 | easy |
3IKDQS3DQE082TOW91W7WDM0PG6CI5 | biomed | Arabidopsis thaliana does not appear to have a pachytene checkpoint akin to that in yeast [11], nor do male Drosophila. | yeast | 0.260417 | easy |
3ZQX1VYFTD5GMC9MQKT7EOM3BXMO86 | biomed | Some of these alleles fail to support viability in a haploid Schizosaccharomyces pombe yeast strain with a null mutation in the XPD homologue rad15 and are thus considered devoid of significant biological activity [19]. | yeast | 0.266667 | easy |
3B623HUYJ4QVK41FX1AGYTW48MU8SS | biomed | This domain is found in a large number of proteins, including Polycomb group (PcG) proteins [18], serine threonine kinases [19], Eph family receptor tyrosine kinases [20], the p73 tumor suppressor [21], the RNA-binding protein Smaug [22], diacylglycerol kinases [23,24], yeast mating type signaling proteins [19,25] and ETS family transcription factors [26,27]. | yeast | 0.357143 | easy |
3NOEP8XAU42OMDMVDSIEJN8MCBRXP4 | biomed | At higher magnification, examination of sections stained with DiI and SYTOX green revealed ultrastructural differences between alphaA/BKO lenses and wild type lenses (Figure 3). | sections | 0.261905 | easy |
3TLFH2L6Y9OLDPC56K65Y7FNO5B2T3 | biomed | Only recently, through the study of a rare human disease, have clues to this process been revealed. | clues | 0.2625 | easy |
3D17ECOUOEV9PNWF8100BB1K21I134 | biomed | Thus, Dmrt7 likely arose, presumably by duplication and divergence of another Dmrt gene, shortly before or coincident with the mammalian radiation. | radiation | 0.2625 | easy |
3FJ2RVH25Z62TA3R8E1O77EBUZ692A | biomed | Evidence of interallelic complementation at clinically relevant loci is limited to biochemical and cell-based studies of a handful of metabolic disorders with defects in enzymes including propinyl-CoA carboxylase [2], argininosuccinate lyase [3], galactose-1-phosphate uridylyltransferase [4], and methylmalonyl CoA mutase [5]. | Evidence | 0.2625 | easy |
3R868ACW4SC7EVTBBRGCMZA5JK2GZG | biomed | A list of the primers used to confirm the expression of olfactory receptor genes by RT-PCR and PCR from cDNA library templates can be found in Additional data file 1. | list | 0.2625 | easy |
3T8DUCXY0N6WD9X4RTLK8UN1UBR9T8 | biomed | Null mutations in Bmpr1a cause early embryonic lethality, with defects in gastrulation similar to those seen in mice with mutations in Bmp4 (Mishina et al. 1995; Winnier et al. 1995). | lethality | 0.263158 | easy |
36818Z1KV3D5JB9F4KTTMCUN6UQA31 | biomed | Furthermore, null mutations in L-Sox5 or Sox-6 cause lethality at or soon after birth, and no effect on cartilage maintenance has been reported (Smits et al. 2001). | lethality | 0.316667 | easy |
3PGQRAZX02KAZASXA58AX6K612QSYL | biomed | Complete lack of huntingtin results in developmental arrest during gastrulation, while severe reduction of huntingtin levels results in abnormal neurogenesis and perinatal lethality [15]. | lethality | 0.35 | easy |
3BAKUKE49HC18PHHJR1WT9408E01R8 | biomed | These Dhcr7 knockout mice are models for human SLOS, especially the more severely affected patients, since early postnatal lethality with respiratory failure has been reported in severe SLOS cases [4,5]. | lethality | 0.382353 | easy |
3K3G488TR280K6307ZE8R97CO88Q5J | biomed | Of these four genes, SAE2 and ZIP1 do not have clear mammalian orthologs (although SYCP1 may be a functional ortholog of ZIP1), and mutation of the mouse RAD17 ortholog, Rad1, presumably causes embryonic lethality [42]. | lethality | 0.4375 | neutral |
38F60IALAGHEHF9RRX2RFJM8R8PT0A | biomed | These results suggest that BMP receptor signaling is essential for continued health and integrity of articular cartilage in the postnatal period. | cartilage | 0.263158 | easy |
359AP8GAGGKBD970QASA5OWRB0V7C5 | biomed | Thin layers of articular cartilage line the bones of synovial joints and provide a smooth, wear-resistant structure that reduces friction and absorbs impact forces (Brandt et al. 1998). | cartilage | 0.3 | easy |
3IVKZBIBJ09ODF28054MB6P3B5KSHR | biomed | Therefore, BMPR1A appears to maintain articular cartilage primarily through inducing expression of key ECM components. | cartilage | 0.359375 | easy |
3RDTX9JRTY19FB0XEQIJ3YVJ5EU97Q | biomed | It is interesting that the SOX9 transcription factor continues to be expressed in mutant cartilage despite loss of Col2a1, a direct target of this transcription factor (Bell et al. 1997; Lefebvre et al. 1997). | cartilage | 0.390625 | easy |
371Q3BEXDH9A40226RATBDT87WTZSI | biomed | PRC1, including ph, recognizes the histone H3 lysine 27 mark set by PRC2 and maintains a stable state of gene repression in which PRC1 blocks chromatin remodeling by the trithorax group-related SWI-SNF complex [46,47]. | mark | 0.411765 | neutral |
39KMGHJ4RZAD16C0TVEHV8K3UWU005 | biomed | Normal differentiation of lens fiber cells consists of a progression from a simple cuboidal epithelial cell, containing a nucleus and a minimal numbers of organelles, to a stratified layer of elongated fiber-like cells, devoid of nuclei and organelles. | nucleus | 0.264706 | easy |
304QEQWKZPKY4N4JVGGSL9GLSZG0O1 | biomed | Pericentric domains from different chromosomes form clusters, which are revealed by FISH as large spots that coincide with DAPI-dense foci in the interphase nucleus (Figure 4A). | nucleus | 0.303571 | easy |
35XW21VSVGEQZBLYRQJK3YIASMOLSM | biomed | In alphaA/BKO lenses the embryonic/fetal nucleus (primary lens fibers) had migrated posteriorly and appeared to be in contact with the posterior capsule. | nucleus | 0.3125 | easy |
3ZQA3IO31BRYBCP1RZKSZEZVXRM1O5 | biomed | In transfected CHO cells, alphaB has also been shown to ectopically localize to interphase nuclei, suggesting a role for this protein in the nucleus [19]. | nucleus | 0.359375 | easy |
3CMV9YRYP31X08284WA6BXRNW3BJL4 | biomed | Expression studies demonstrated the distribution of Annexin A7 in a wide variety of tissues and cells mainly enriched in the cytosol in close association with membranous structures, but it was also described in the nucleus of adrenal chromaffin cells [4]. | nucleus | 0.375 | easy |
3R0WOCG21M9NGCPA3EGWZMST4A7DUE | biomed | The loss of Sertoli cells in XY Fgf9 −/− gonads is not due to cell death, but instead to a transition of supporting cell fate as SOX9 expression is lost. | transition | 0.264706 | easy |
3WKGUBL7SZM7XQJN1PN25V24E7JL4F | biomed | The fact that Sam68−/− osteoclasts looked and acted like Sam68+/+ osteoclasts ex vivo and in vivo made it unlikely that this was the primary source of the difference in bone metabolism in 12-month-old Sam68−/− mice. | source | 0.264706 | easy |
30UZJB2POHC8D5XY9O2CE1E1EGP53Q | biomed | Disruption of Capn1, encoding the μ-calpain catalytic subunit, was subsequently reported to result in fertile, viable mice with some mild defects in the μ-calpain rich platelets relating to their aggregation and clot retraction [33]. | Disruption | 0.264706 | easy |
31S7M7DAGGQREBYDGQOAD3EWU57LTG | biomed | Data from a number of previous studies also show that different olfactory receptor genes, or even copies of the same olfactory receptor transgene in different genomic locations are expressed in different numbers of cells [14,18,35], but do not address the issue of transcript level per cell. | copies | 0.264706 | easy |
39XCQ6V3KY47AOKGSQ0AL4QLO7R56W | biomed | The morphological differences in alphaA/BKO lenses, compared to age matched wild type lenses, were consistent with the hypothesis that alpha-crystallin plays an active role in the differentiation and growth of lens fiber cells. | hypothesis | 0.264706 | easy |
3QX22DUVOOHQXLKNLXP4EYH6RV8MVU | biomed | Histochemical analysis was performed to verify this hypothesis. | hypothesis | 0.275 | easy |
3QX22DUVOOHQXLKNLXP4EYH6RVDVM8 | biomed | To test the hypothesis that a temporal delay in the onset of transcriptional programs is crucial for the control of appropriate neuronal maturation, we studied the development of proprioceptive DRG neurons, since transcriptional effectors regulated by target-derived signals, as well as some of their downstream biological actions, have been identified for these neurons. | hypothesis | 0.283333 | easy |
3MNJFORX8B43THDRTJ3EFA3YH605F5 | biomed | The lack of cellar organization and uniform cell shape at the equatorial region observed in alphaA/BKO lenses supports this hypothesis. | hypothesis | 0.375 | easy |
3WRKFXQBOB7L5WP15TEWT4EJS3VIYO | biomed | This hypothesis is amenable to testing in the Dhcr7 null mice. | hypothesis | 0.383333 | easy |
3ACRLU860NEDCJU4ZIAL0EIQF16EBW | biomed | It is notable that, despite extensive analysis of Fog2 biology and the generation of a Fog2 knock-out mouse, its role in diaphragm and lung development was previously not recognized. | biology | 0.264706 | easy |
3KI0JD2ZU1IMXSYZGJF7JO4HFDR67H | biomed | Dual color imaging of several GFP variant proteins is a very attractive prospect and has become a standard procedure in cell biology [7,8]. | biology | 0.34375 | easy |
31N9JPQXIPIRX2A3S9N0CCFXO67HNZ | biomed | Similarly, CAF-1 is essential in mammalian cell lines for the progression of DNA replication [16,23,24,34]. | replication | 0.264706 | easy |
3Z33IC0JC0MBQ11TWOLZ9CBMRW79VO | biomed | DNA helicase is a central factor for operation of replication forks. | replication | 0.3 | easy |
33P2GD6NRNSQPWP0VWVKKKYTUB7KH2 | biomed | Unexpectedly, Mcm4/6/7 helicase is not capable of efficiently unwinding the GC-rich duplex segment, suggesting that some other mechanism may be required for completion of replication of the entire genome. | replication | 0.305556 | easy |
3421H3BM9AH2Z61ZFZ7G6O0SW9UJ97 | biomed | The annexins may participate in a nuclear response to initial cell stimulation or to a Ca2+-transient, presumably by regulating DNA replication. | replication | 0.325 | easy |
3AXFSPQOYQYB0GSCIL78GKM3Z7UJF4 | biomed | It also plays a crucial role in the initiation step at the replication origins. | replication | 0.428571 | neutral |
3W5PY7V3UP7H0797NBZW55TJ5JDYJB | biomed | Of note, although some of their results were confirmed in our study, we found a fundamentally different phenotype with regard to clearance of apoptotic cells. | regard | 0.264706 | easy |
3ULIZ0H1VA5C32JJMKOTQ8Z4GWH514 | biomed | In order to generate a DsRed variant that may be amenable to use in ES cells and mice, we recently introduced various sequences that direct nuclear localization to the DsRed coding region. | sequences | 0.265625 | easy |
31JUPBOORN48GR6PDSDFM7I9GSHL8M | biomed | The site of mutation is of interest, particularly the fact that in each of the three families the telomeric end of the deletion is anchored between exons 3 and 4 of SUMF1; sequence searches failed to identify any repeat sequences that might explain this phenomenon. | sequences | 0.283333 | easy |
391FPZIE4CM4SSUCPAZMQ77RW26HUX | biomed | ADAM22 and ADAM23 share highly homologous sequences in their extracellular domains. | sequences | 0.3 | easy |
36JW4WBR06KF9AXMUL4N476OMFQFHV | biomed | Our results and the sequences we provide will facilitate future global studies of the mechanisms and dynamics of olfactory receptor gene expression. | sequences | 0.375 | easy |
3XDJY5RK5SLAGG6HA3F3WIYNRXDU4H | biomed | Recent evidence points toward a transcriptional coactivator, peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α), as an integrator of the molecular regulatory circuitry involved in the transcriptional control of cellular energy metabolism, including mitochondrial function and biogenesis [1,2]. | energy | 0.265625 | easy |
3OJX0UFJ0Z7BDMCTRYBUDQ93DPY9UZ | biomed | However, the necessity of PGC-1α for energy metabolic homeostasis, mitochondrial biogenesis, development, and growth can only be addressed using loss-of-function strategies. | energy | 0.266667 | easy |
372AGES0I459YQ2AQKM3OI81DTFRXQ | biomed | For example, a skeletal muscle phenotype was unveiled in PGC-1α−/− mice under conditions in which energy supply becomes limiting. | energy | 0.28125 | easy |
3D06DR5225J65XHPA2Y8IB3T6M5MAT | biomed | Photoreceptor cells play a primary role in vision by capturing light energy and converting it into neural stimuli. | energy | 0.322917 | easy |
3WYZV0QBFJDMIJLLUN0DO33XV7HXBO | biomed | The basis for the observed abnormalities of cardiac heart rate, including a blunted response to β-adrenergic stimulation, is unknown, but could be related to the effects of late-stage growth arrest and corresponding derangements in energy metabolism on sinus node function. | energy | 0.34375 | easy |
324N5FAHSXBV7XKK0LCOZLP22QDKVN | biomed | The second paper providing evidence, by Davies et al [26], is a biochemical study of the interaction between the homologous recombinase RAD51 and a peptide consisting of one of the eight BRC repeats from human BRCA2. | Davies | 0.321429 | easy |
3A520CCNWN08T9PCT4AP53YKXJLEA1 | biomed | Taken together, these observations suggest that Tas2rs are quite tolerant of variation, and that perhaps most of the differences observed do not affect domains important for ligand interactions or receptor-mediated signaling mechanisms. | domains | 0.265625 | easy |
3AXFSPQOYQYB0GSCIL78GKM3Z7PFJV | biomed | Individual pericentric domains from single chromosomes are now found either isolated or aggregated in a pattern less dense than the regular clusters observed in control cells (Figure 4B). | domains | 0.315789 | easy |
3UDTAB6HH6ZVX00DTRXAOJLWX0U09N | biomed | Our findings reveal a role for CAF-1 in the nuclear organization of heterochromatin domains during early development and in ES cells. | domains | 0.339286 | easy |
31D0ZWOD0AZ92JAILXBAKEWG3I6A06 | biomed | While this has to be addressed experimentally, it is worthwhile to mention an alternate possible mechanism that might explain the disruption of heterochromatin domains in p150CAF-1 null embryos and ES cells. | domains | 0.352941 | easy |
386659BNTLHD8VXIPEIH9D3DZO110A | biomed | Heterochromatin domains are progressively assembled into DAPI-dense foci between the four-cell and 32-cell blastocyst stages (Figure 1F). | domains | 0.4 | neutral |
3PMR2DOWOO1TV1G2927VO667SGL45A | biomed | Target-derived factors have also been implicated in controlling neuronal maturation of predetermined neurons in Drosophila, in which expression of members of the BMP family in the target region is essential for the induction of mature peptidergic properties in a subpopulation of neurons marked by the coordinate expression of the two transcription factors Apterous and Squeeze [11,12]. | properties | 0.265625 | easy |
3D4BBDG7ZHWTCQ6DOYPKS7KB6XC3CX | biomed | The rationale for RMCE-ASAP is detailed in Figure 1. | rationale | 0.265625 | easy |
3IVKZBIBJ09ODF28054MB6P3B5FHSB | biomed | We screened a mouse olfactory epithelium library with degenerate olfactory receptor probes and obtained 5' end sequences (ESTs) from purified cDNAs. | library | 0.265625 | easy |
3LXX8KJXPW9G0HSWVCZLEKHEV39O90 | biomed | A list of the primers used to confirm the expression of olfactory receptor genes by RT-PCR and PCR from cDNA library templates can be found in Additional data file 1. | library | 0.3 | easy |
3I4E7AFQ2KZLJLADD5CXXO14QGXTJH | biomed | Previous genomic library screening by identified genomic clones containing the mouse ESG1 gene and seven pseudogenes [17]. | library | 0.390625 | easy |
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