id stringlengths 30 30 | corpus stringclasses 3 values | sentence stringlengths 10 1.38k | token stringlengths 1 16 ⌀ | complexity float64 0 0.86 | difficulty stringclasses 5 values |
|---|---|---|---|---|---|
3BFF0DJK8XCEIOT30ZLBPPSRMZFST1 | biomed | A genome database search revealed orthologs of ADAM11, ADAM22 and ADAM23 genes to exist in vertebrates such as mammals, fish, and amphibians, but not in invertebrates. | invertebrates | 0.366667 | easy |
38G0E1M85M59ATPWUZGQ58Y04I9VUV | biomed | Indeed, although PGC-1α null mice survive in the protected environment of the laboratory, our results indicate that in the rigors of a typical external environment, PGC-1α would be necessary for survival. | laboratory | 0.322917 | easy |
3KI0JD2ZU1IMXSYZGJF7JO4HFDM67C | biomed | AQP2-F204V, on the other hand, appeared in a punctate but perinuclear pattern (Figure 4B, third column). | column | 0.323529 | easy |
391JB9X4ZY8CHAQBMTBXCP6PBX1MK8 | biomed | Upon stimulation with forskolin, a cAMP-dependent protein kinase activator, wild-type AQP2 translocated to the apical surface of polarized MDCK cells (Figure 4B, second column). | column | 0.416667 | neutral |
3XUSYT70IT170QDU572CAF4MOL3D0B | biomed | Mitochondrial functional capacity is dynamically regulated to meet the diverse energy demands imposed on the mammalian organism following birth. | organism | 0.323529 | easy |
3TRB893CSJAOULN5SWOTVFH69RUG7T | biomed | Another prediction, based upon the enzyme and mRNA levels in knockout mice, is that if these mice are placed on a high cholesterol/high sitosterol diet, they may show significant accumulation of both sterols in the body. | enzyme | 0.325 | easy |
3NSCTNUR2ZN8XQWJI3HM19S7KQN5AS | biomed | Several inhibitors of γ-secretase have already been produced [8,9], and small molecule inhibitors of β-APP cleaving enzyme 1 are currently being developed [10,11]. | enzyme | 0.357143 | easy |
3IV1AEQ4DRD2L1IPA7126S5HC3HJ8N | biomed | MCAD-deficient patients have abnormal plasma and urine metabolites associated with the medium chain–length enzyme specificity. | enzyme | 0.48913 | neutral |
3Q9SPIIRWJM2A9B3E44VR95K4NQWAZ | biomed | However, the mutation in this model disrupts a splice site in the mitochondrial branched-chain aminotransferase (BCAT) gene, not in BCKDH, the deficient enzyme in MSUD. | enzyme | 0.514706 | neutral |
3IJ95K7NDXCDX6FS835IRC3W97SGNZ | biomed | The presence of nuclear Annexin A7 in murine brain was confirmed by controls using sections from the AnxA7-/- mouse and by a biochemical extraction of the protein from the nucleus. | extraction | 0.325 | easy |
375VSR8FVW9Y3L2PR2AOL3OCLTCZRU | biomed | The hallmarks of intermediate MSUD human patients are persistently increased levels of BCAA and BCKDH activity in the range of 3-30% of normal [1]. | hallmarks | 0.325 | easy |
3TZDZ3Y0JS6V4PLVPA1A2O462TT19M | biomed | The exposure of the phospholipid phosphatidylserine (PS) in the outer leaflet of the plasma membrane of apoptotic cells has been described as one of the hallmarks of the induction of apoptosis and is considered to be one of the most important signals required for apoptotic cell recognition and removal [19]. | hallmarks | 0.367647 | easy |
31N9JPQXIPIRX2A3S9N0CCFXO6DHN5 | biomed | We show that targeted expression of an activated form of PPARδ produces profound and coordinated increases in oxidation enzymes, mitochondrial biogenesis, and production of specialized type I fiber contractile proteins—the three hallmarks for muscle fiber type switching (Figure 6C). | hallmarks | 0.4 | neutral |
3QXFBUZ4ZKGQSWZ154H457VQH2SUGA | biomed | Strikingly, Dmrt7 is present, not only in placental mammals, but also in marsupials and a monotreme (egg-laying mammal), the platypus, which has a clear Dmrt7 ortholog [36]. | marsupials | 0.325 | easy |
33Q5P9PUSPMUXJD695KTW8PQLSFCZ7 | biomed | For example, expression defects in the KH domain proteins NOVA and FMRP are known to cause paraneoplastic neurologic disorders [31] and the fragile X syndrome, respectively, in humans [32]. | X | 0.325 | easy |
3J94SKDEKIP6VXZV2D8ORA0D5TED5W | biomed | In prophase I, when the homologous chromosomes synapse and homologous recombination occurs, X and Y chromosome pairing is limited to a region termed the pseudoautosomal region, leaving large portions of each chromosome unpaired. | X | 0.365385 | easy |
3PN6H8C9R4Q313BCX9Z5ZLGZX7KDA7 | biomed | These include the enhancement of the biogenesis of red/green opsin by the combination of the RBD4-CY domains [6,7] and the stabilization by the Ran-binding domains of RanBP2 of the guanosine triphosphate-bound conformational state of RanGTPase and interaction of Ran with importin-β [11,40,41]. | enhancement | 0.325 | easy |
37NXA7GVST66R322LLOPEL2HRQIVL1 | biomed | Recombinase-Mediated Cassette Exchange (RMCE) approaches were developed to improve targeting efficiency using a two-step process: the gene of interest is first replaced by a selection cassette flanked by recombinase target sites (e.g. loxP sites for Cre recombinase, to create a ‘floxed’ locus). | Exchange | 0.326923 | easy |
3J5XXLQDHMBPBZCDFFKPIZ80R4WV3S | biomed | At the other extremity, photoreceptors terminate with synaptic endings that make contact with the processes of horizontal and bipolar cells [31,32]. | extremity | 0.326923 | easy |
3OB6JN3A9QPY4E36CDKUD1S36QTRM6 | biomed | However, several physiological studies have suggested that quinine can directly activate G proteins or cationic conductances, or can block K+ channels in taste receptor cells [34-36]. | receptor | 0.328125 | easy |
3BCRDCM0ODUAS75JZD4GNT93LYJK6V | biomed | Furthermore, a number of physiological studies have suggested that the transduction of some amphiphilic bitter compounds, such as quinine and denatonium benzoate, may stimulate taste receptor cells independently of GPCRs (e.g. [30]). | receptor | 0.338235 | easy |
3OKP4QVBP2X6DNL3ZZ0D56JWAZVAG9 | biomed | This is unlikely, however, as even olfactory receptor transgenes with identical upstream regions are expressed in different neurons [18]. | receptor | 0.375 | easy |
3I6NF2WGIGW97H9M439WXV3AILZG5E | biomed | TRIP13 was originally discovered to be an interactor with rat thyroid receptor beta (THRB; [54]), but the relationship between THRB and TRIP13 in meiosis is unknown. | receptor | 0.375 | easy |
3AA88CN98P3CBRFP5WZ86KTWK7KYKF | biomed | Each olfactory receptor is expressed in a subset of cells in one of four zones of the epithelium [14,15]. | receptor | 0.388889 | easy |
3IH9TRB0FBZOFQEYT47NFH39LJFI1L | biomed | The conditional alleles were deleted early in limb development through the action of a cre-recombinase transgene expressed under the control of the Prx1 enhancer [32]. | enhancer | 0.328125 | easy |
34KYK9TV2R8EM2ZM0DUQPVM5GSFBSU | biomed | These findings, taken together, indicated that the phenotype associated with Apcs deficiency was caused by the presence of unaltered 129 genes from the telomeric region of Chromosome 1 operating in the C57BL/6 genomic background. | operating | 0.328125 | easy |
3P520RYKCH6SCZAHO8YD1A41RT8U5M | biomed | Adult skeletal muscle shows plasticity and can undergo conversion between different fiber types in response to exercise training or modulation of motoneuron activity (Booth and Thomason 1991, Jarvis et al. 1996; Pette 1998; Olson and Williams 2000; Hood 2001). | Booth | 0.328125 | easy |
3FVBZG9CLJEOC6IWR3L210JKGDWH0O | biomed | Type IIb fibers have the lowest levels of mitochondrial content and oxidative enzymes, rely on glycolytic metabolism as a major energy source, and are susceptible to fatigue, while the oxidative and contraction functions of type IIa and IIx lie between type I and IIb (Booth and Thomason 1991; Berchtold et al. 2000; Olson and Williams 2000). | Booth | 0.47619 | neutral |
38B7Q9C28G5QBBMSVGDRXKVNA3G96X | biomed | Annexin A7, the first annexin to be described, was isolated as the agent that mediated aggregation of chromaffin granules and fusion of membranes and phospholipids in the presence of Ca2+-ions [3]. | fusion | 0.328125 | easy |
38LRF35D5LWPYKNDAPAKMD6HDXNU32 | biomed | In Wnt4 mutants, SOX9 expression is not maintained. | mutants | 0.328125 | easy |
3D06DR5225J65XHPA2Y8IB3T6L7AMH | biomed | Already at E10.5, we could see intense apoptosis among the postmigratory NCCs in the mesenchyme surrounding the aortic sac at the site where the prospective AP septum forms, i.e., this cell death precedes the AP septal defect seen in mutants. | mutants | 0.34375 | easy |
3HO4MYYR12OOV3AVTR8ITGI1NPJ6UG | biomed | Other factors, such as GDNF [11,40] need to be investigated in their expression in these mutants and their functional role needs to be assessed, in particular in the cochlear apex. | mutants | 0.375 | easy |
3JMNNNO3B14D56GZ1PBGLRMMSZT2WT | biomed | In one study, 12 distinct measures of Wnt signaling in Pygo mutants were performed, including analysis of leg, wing, and eye imaginal discs. | mutants | 0.416667 | neutral |
37G6BXQPLQL0GPWTI07BV3DP112EQ3 | biomed | Moreover, the Alk5/Wnt1-Cre mutants display an abnormal patterning of the aortic sac and defective AP septation leading to PTA, reminiscent of type A2 (= truncus artriosus with no main pulmonary artery segment present [30]). | mutants | 0.472222 | neutral |
3TTPFEFXCTKJQH4BTS1JA1TBTHGH6P | biomed | In this assay, serial dilutions of protein homogenate are passed through a cellulose acetate filter; particles larger than the pore size of the filter become trapped in the membrane and are revealed by immunoblotting [22]. | pore | 0.328947 | easy |
34ZTTGSNJXOC0ZNV81FHG6A2THZQH0 | biomed | These changes are less directly related to specific mutations in the CFTR gene and are likely related to other differences in individual genetic makeup. | makeup | 0.329545 | easy |
359AP8GAGGKBD970QASA5OWRBZ37CB | biomed | In this assay, serial dilutions of protein homogenate are passed through a cellulose acetate filter; particles larger than the pore size of the filter become trapped in the membrane and are revealed by immunoblotting [22]. | particles | 0.329545 | easy |
32204AGAABCLNATH55A5MS60NVJHGR | biomed | We observed among individual mice a striking variability in olfactory memory performance but not in odor discrimination. | variability | 0.333333 | easy |
3BA7SXOG1JQJJP12ICAB8JR8MKBR8N | biomed | Fiber cells attached to the posterior capsule and extending anteriorly were observed in 5 wk (Figure 3O), 46 wk (Figure 3T) and 72 wk (data not shown) wild type lenses. | Fiber | 0.333333 | easy |
3BJKPTD2QCC2H9TQLAL6ZFNV0XWTRE | biomed | Cultured Fog2 lungs do develop an intricate branching pattern in the unaffected lobes that appears similar in the pattern to wild-type lungs after 5 d in culture. | lobes | 0.333333 | easy |
3PA41K45VN4U7YG4VFEGPOVYAIC7PJ | biomed | Alternative splicing gives rise to two isoforms of 47 and 51 kDa. | splicing | 0.333333 | easy |
3MNJFORX8B43THDRTJ3EFA3YH7SF59 | biomed | We find that the majority of the olfactory receptors, like most non-olfactory receptor genes [38,39], are transcribed as multiple isoforms, involving alternative splicing of 5' untranslated exons and alternate polyadenylation-site usage. | splicing | 0.4 | neutral |
3WUVMVA7OB3644G8PRO2QDZ2LPUZAS | biomed | Given the location of this alteration it is unlikely to effect the expression or splicing of ITPR1. | splicing | 0.402174 | neutral |
34HEO7RUG6UX2DUHFAUP4AX3C8BARA | biomed | Given that SCA16 and autosomal dominant congenital nonprogressive ataxia have both recently been mapped to regions overlapping with the SCA15 locus [10,11], ITPR1 is a gene of importance for screening in these families. | screening | 0.333333 | easy |
3I4E7AFQ2KZLJLADD5CXXO14QG2TJM | biomed | An important one appears to be Ca2+, which promotes binding of Annexin A7 to membranes and also allows aggregation of annexins [27]. | aggregation | 0.333333 | easy |
3PIOQ99R7YMW2OGNS8UZVR4NIF6UNC | biomed | Reports by Clemen et al. [9] and Herr et al. [8,10] demonstrated roles for Annexin A7 in shape and osmotic resistance of red blood cells, platelet aggregation velocity, and in the velocity of spreading astrocytic Ca2+-waves. | aggregation | 0.455882 | neutral |
3P4ZBJFX2V3X60SBPKQN5AGB133FWV | biomed | During the early 1990's, alpha-crystallin was shown to act as a molecular chaperone, binding to partially denatured proteins, both in vitro [5] and probably in vivo [6], to inhibit further denaturation and aggregation of lens proteins. | aggregation | 0.466667 | neutral |
3OEWW2KGQJBS375D7S4N0G04MOJDO1 | biomed | Previous results in which annexin A7 was shown to play a role in membrane aggregation might be explained by a supportive function of annexin A7 in that it interferes with the local Ca2+ homeostasis thus influencing membrane organization. | aggregation | 0.5 | neutral |
3PZDSVZ3J5HXLQM8D23HIN6TJ1R4N6 | biomed | Clot formation and lysis, which ultimately determine thrombosis, requires platelet aggregation, coagulation, and fibrinolytic functions. | aggregation | 0.55 | neutral |
3FULMHZ7OUXR381811OH58HTEC9M4I | biomed | The adult heterozygous females showed a mild tendency toward increased urinary output and water intake and decreased urine osmolality. | females | 0.333333 | easy |
38Z7YZ2SB32CWUYFEJX2GIBHTUEIQL | biomed | Loss or damage to articular cartilage is a hallmark of arthritic diseases and is one of the most common reasons that both young and old adults seek medical care. | hallmark | 0.333333 | easy |
3SMIWMMK615MPIP1K9LMRAHEBRAUW3 | biomed | Alternatively, PPARδ may be activated by a distal upstream signaling component such as a kinase cascade. | component | 0.333333 | easy |
3BFNCI9LYKQN09BHXHH9CLSX5ML374 | biomed | Mutations in this gene underlie McArdle's disease (glycogen storage disease type V), the symptoms of which include exercise intolerance, muscle cramps, and myoglobinuria [36]. | Mutations | 0.333333 | easy |
371DNNCG442WZ4EUM1F68YSQA58T82 | biomed | Mutations in the genes of the E1 and E2 subunits of BCKDH have been described, however, the majority of MSUD mutations identified thus far are in the E2 subunit [1,7]. | Mutations | 0.390625 | easy |
3VDI8GSXAFTSUZSO21GZ9FD1KBVG8B | biomed | In contrast, our studies show a relocation of Annexin A7 from the cytosol to the nucleus in cells of the embryonic neuronal tissue. | relocation | 0.333333 | easy |
3GVPRXWRPHU2QCT0IKOWGRUMO4H7I7 | biomed | The pachytene checkpoint is known to monitor two aspects of meiotic chromosome metabolism in S. cerevisiae and C. elegans: (1) DSB repair and (2) chromosome synapsis [2,12]. | metabolism | 0.3375 | easy |
3TC2K6WK9G22F5KH3MVA7BJ0ASW28K | biomed | Lastly, we propose that the PGC-1α−/− mice should serve as a useful murine model to investigate the role of altered energy metabolism in obesity, diabetes, hepatic steatosis, and diseases of the heart, skeletal muscle, and central nervous system. | metabolism | 0.359375 | easy |
391JB9X4ZY8CHAQBMTBXCP6PBX1KM6 | biomed | As mentioned above, Nrl is a retinal transcription factor that, when mutated, results in en masse conversion of rods into S-opsin–expressing cones [24]. | conversion | 0.338235 | easy |
3GITHABACYLNIC7L9OKTP89VZNUN2S | biomed | This conversion of muscle fiber from type IIb to type IIa and type I is likely to be mediated by a calcium signaling pathway that involves calcineurin, calmodulin-dependent kinase, and the transcriptional cofactor Peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) (Naya et al. 2000; Olson and Williams 2000; Lin et al. 2002; Wu et al. 2002). | conversion | 0.35 | easy |
3I7KR83SNADXAQ7HXK7S7305BZSK97 | biomed | Thus, during the evolution of vertebrates, subsequent successive duplications of the ancestral gene cluster have given rise to three TACC family members located close to FGFR genes in humans. | duplications | 0.338235 | easy |
3S37Y8CWI80N8KVM53U4E6JKCDUW4O | biomed | In fact, the most likely candidates for a cellular correlate of olfactory memory appear to be the neuronal connections in the piriform cortex due to the associational connectivity [5] and the expression of several forms of cellular and synaptic plasticity [7,20–23]. | connectivity | 0.338235 | easy |
3O2Y2UIUCQU6B0YU067KHZMGEWUKF4 | biomed | Er81 controls proprioceptive afferent connectivity [14], and we therefore sought to identify an ETS transcriptional regulator that, when expressed over the normal time course of Er81 expression, is able to substitute for Er81 function within group Ia afferent sensory neurons. | connectivity | 0.470588 | neutral |
3VEI3XUCZRX4PH0J4TCMU5MYBU6PR0 | biomed | Success with animal studies is expected to advance such therapeutic approaches and could pave the way for studies in humans. | Success | 0.338235 | easy |
30IRMPJWDZJ3EQ33R17EYO0ZHK0KRU | biomed | Nutritional problems can persist even with adequate oral enzyme supplementation [9] and neutralization of gastric acid to improve lipase function [10], and may involve both impaired digestion and absorption of nutrients [11]. | absorption | 0.338235 | easy |
3538U0YQ1FU0F2QNF0FL0D5E3A83FC | biomed | These models will allow for the development of novel treatment approaches, such as gene or stem cell therapies, to ultimately cure MSUD. | stem | 0.339286 | easy |
3HXK2V1N4KFH8KQZMK7YZO0YYB32GU | biomed | As noted, whereas Capn2 null murine embryos die prior to implantation, homozygous disruption of the μ-calpain large subunit gene, Capn1, did not affect the viability of mice [33]. | implantation | 0.339286 | easy |
3IVEC1GSLPZKA1Y4BMSNRII9YX6J1Y | biomed | We report here that Capn2 null embryos died prior to the implantation stage, indicating that m-calpain is indispensable for early embryogenesis. | implantation | 0.345238 | easy |
34F34TZU7WZRZMG0UQS1W1SEQ3KJ2F | biomed | Type IIb fibers have the lowest levels of mitochondrial content and oxidative enzymes, rely on glycolytic metabolism as a major energy source, and are susceptible to fatigue, while the oxidative and contraction functions of type IIa and IIx lie between type I and IIb (Booth and Thomason 1991; Berchtold et al. 2000; Olson and Williams 2000). | Williams | 0.340909 | easy |
3FO95NVK5C0129GBWAGGPAR9YEDSRJ | biomed | Wnt9b is made by the ureteric bud and induces the metanephric mesenchyme to undergo nephrogenesis [2]. | bud | 0.342105 | easy |
3QE4DGPGBRBRBY5MQYQMS3XWIP54GY | biomed | In conclusion, the mammalian Pygo2 gene is required for normal branching morphogenesis of the ureteric bud, with mutants showing dilated tips and reduced numbers of tips. | bud | 0.361111 | easy |
3YLPJ8OXX8D2XK0CF8QQGPXRLF14XQ | biomed | In addition, Wnt11 is produced by the ureteric bud tips and induces GDNF expression in the metanephric mesenchyme [4]. | bud | 0.363636 | easy |
3G57RS03HH5JSN1F5OO7VR9982P52F | biomed | The development of a bud requires a number of coordinated changes in the behavior of the targeted cells within an epithelial sheet. | bud | 0.40625 | neutral |
3LVTFB9DE5IY03SKOVXZV6Y1EHMQG1 | biomed | This exquisite pattern appears to be functionally relevant since altering it in vivo correspondingly affects features associated with hair bud formation, including down-regulation of E-cadherin, increased proliferation, and repressed terminal differentiation. | bud | 0.431818 | neutral |
3IKMEYR0LWVMA6MICBSDXGSR5SK2KX | biomed | Sequence homology analyses revealed that Acdp proteins shared very strong AA homologies to the bacteria CorC protein and yeast Amip3 protein. | Sequence | 0.34375 | easy |
37G6BXQPLQL0GPWTI07BV3DP118EQ9 | biomed | Huntingtin is postulated to function as a flexible ~350 kDa HEAT domain scaffold that may facilitate the assembly and possibly the subcellular location of large protein complexes [3-7]. | HEAT | 0.34375 | easy |
3ZXV7Q5FJBOOS2M68TQMTG989OECFE | biomed | At some sites, loss of Bmpr1a function leads to a defect in the early stages of joint formation, resulting in a complete failure to form a joint and fusion of bones in the ankle. | defect | 0.34375 | easy |
341H3G5YF0EA3RIQXPR917NPC3J0Z3 | biomed | The severity of pulmonary hypoplasia in the patient we report was out of proportion to that of the diaphragm defect. | defect | 0.347222 | easy |
3IZPORCT1F9CC02VLG4HLWK7P32HRT | biomed | In conclusion, these results show that p150CAF-1 is required for the proper condensation and clustering of pericentric heterochromatin domains. | clustering | 0.34375 | easy |
3OJX0UFJ0Z7BDMCTRYBUDQ93DPS9UT | biomed | CAF-1 could be required for the loading, into heterochromatin, of an interacting partner required for the clustering of pericentric domains. | clustering | 0.34375 | easy |
3SCKNODZ0XGU4D4RF01OLZQ3A3BN73 | biomed | The role of CAF-1 in the nuclear organization of heterochromatin includes spatial localization, condensation, and clustering of pericentric domains. | clustering | 0.470588 | neutral |
32K26U12DNONTREA84Q1V8UCIHGVDL | biomed | They result from the clustering of sphingolipids and cholesterol in the outer leaflet of the membrane connected to phospholipids and cholesterol in the inner leaflet and are enriched in special proteins. | clustering | 0.526316 | neutral |
3GONHBMNHVY765PXMUE7Z4U2F6JMZZ | biomed | Moreover, the cost associated with liver transplantation and the availability of donor livers are additional limiting factors for the practicality of treatment of this disease. | transplantation | 0.34375 | easy |
31GECDVA9JM3TSKUX9AFDA4LK2366E | biomed | Because of the central role of the liver in amino acid metabolism and moderate/high levels of BCKDH activity in human liver [10-12], a few cases of MSUD have recently been treated by liver transplantation [13-16]. | transplantation | 0.361111 | easy |
363A7XIFV4MPVKBYOUZZ57M6XEJVAJ | biomed | Embryonic expression and transplantation studies suggest that Tbx15 is required to establish certain characteristics of dorsal patterning in mesenchymal cells of the developing flank. | transplantation | 0.366667 | easy |
36MUZ9VAE626RGSODE1RV46QIMIDE2 | biomed | The first Transforming acidic coiled coil gene, TACC1, was identified during the development of an expression map of the proximal short arm of human chromosome 8 [1]. | arm | 0.34375 | easy |
3YLTXLH3DF6R0NMG8O0SG1KSOM6HPV | biomed | To allow for the mechanistic separation of olfactory learning, discrimination, and memory, we exploited a well-known phenomenon of transgenes, which concerns heterogeneous expression among different founder lines and even among genetically identical individuals of a given line. | founder | 0.34375 | easy |
3UYRNV2KITZY4R9AP5TUZZMYLNMN8V | biomed | Significantly, the reports cited above failed to address the technical limitations of the approach: i.e. that the antagonists used lack adequate subtype specificity and only partially blocked D2R-mediated signaling thus making it impossible to rigorously assess the role of D2R-mediated signaling in associative and reversal learning. | specificity | 0.34375 | easy |
3J94SKDEKIP6VXZV2D8ORA0D5TE5DO | biomed | The quest to understand the HD mechanism, therefore, is aimed at delineating the huntingtin activity that may explain the striatal cell specificity of the polyglutamine mutant version of huntingtin. | specificity | 0.388889 | easy |
3AQN9REUTFG4XL9FDFDL27Y60YNDYH | biomed | These will be important for implicating candidates to be assessed in the extraembryonic signals that determine anterior streak progression in the developing embryo and in delineating the dominant activity of the polyglutamine tract in huntingtin that determines the striatal specificity of HD. | specificity | 0.4 | neutral |
360ZO6N6J1JS0E7KIWK8MGS903UM9J | biomed | MCAD-deficient patients have abnormal plasma and urine metabolites associated with the medium chain–length enzyme specificity. | specificity | 0.45 | neutral |
3APP19WN71E5QL909MJ1P1HAEGB6GL | biomed | The μ-80 k and m-80 k subunits share 62% amino acid sequence identity, and are very similar in terms of structure, protein chemistry, and in vitro substrate specificity. | specificity | 0.470588 | neutral |
3JYPJ2TAYI87MRVADYCSDG8F86VPF5 | biomed | The mab-3 gene of Caenorhabditis elegans has been shown to function analogously to DSX in several respects and can be functionally replaced by the male isoform of DSX, suggesting that the similarity in the sequence of these genes may stem from conservation of an ancestral DM domain sexual regulator [18,21,22]. | similarity | 0.34375 | easy |
33QQ60S6ASITHSOGR2S1KF8AAL3U07 | biomed | Hedgehog family members play diverse roles in embryonic development, and cholesterol is necessary for maturation of these morphogens [20-23]. | Hedgehog | 0.34375 | easy |
3WPCIUYH1A88GZAL39QMUQ6RLW5DTS | biomed | In this study, we have used mouse genetics to test this general idea, by investigating whether the precise timing of onset of ETS transcription factor signaling is essential for normal sensory neuron development. | neuron | 0.346154 | easy |
35JDMRECC499302FF42Z1P9NVFRGEA | biomed | Changes in neuron excitability in the hippocampus, such as decreases in the post-burst after hyperpolarization (AHP), have been thought to affect long-term potentiation (LTP) [36], an experimental model of the synaptic changes thought to underlie learning and memory [37]. | neuron | 0.411765 | neutral |
3GS542CVJVNUS7MEQX3M5EHNE8559D | biomed | This late sensory neuron loss is likely not related to known neurotrophin signaling which becomes reduced in neonatal wildtype animals. | neuron | 0.428571 | neutral |
3ZRKL6Z1E83ADJ7XGZM4Q6D2W52SGN | biomed | Supplementary data are available at NAR online. | Supplementary | 0.347222 | easy |
3Z56AA6EK405IV5MKPHW2617A2MM68 | biomed | But when given liver X receptor alpha (LXRα) agonist, Abcg5/sterolin-1 and Abcg8/sterolin-2 appeared to be expressed at the apical surface. | alpha | 0.347826 | easy |
3T5ZXGO9DEOYRKNPENLOGDE7P88ZQT | biomed | This may support the idea that mr-s is involved in repressive complexes similar to other SAM domain-containing proteins. | complexes | 0.347826 | easy |
37NXA7GVST66R322LLOPEL2HRRGLVR | biomed | Cells lacking BRCA1/2 fail to form damage-induced subnuclear RAD51 foci with normal efficiency, suggesting that these proteins are required for the formation of recombinase complexes at the sites of DNA damage [20,21]. | complexes | 0.4 | neutral |
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