title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Engineering tandem modular protein based reversible hydrogels. | We report the engineering of the first tandem modular protein based hydrogel that exhibits unique properties combining low erosion rate, fast and reversible sol-gel transition and antibody binding ability. | 18,802,510 |
Facile one pot synthesis of a range of reversible addition-fragmentation chain transfer (RAFT) agents. | The application of a universal synthetic strategy for the high yielding and facile synthesis of a wide range of functional RAFT agents including trithiocarbonates, xanthates and dithiocarbamates is described. | 18,802,523 |
Chemogenetic protein engineering: an efficient tool for the optimization of artificial metalloenzymes. | Artificial metalloenzymes, based on the incorporation of a catalytically active organometallic moiety within a host protein, lie at the interface between organometallic and enzymatic catalysis. In terms of activity, reaction repertoire, substrate range and operating conditions, they take advantage of the versatility of... | 18,802,535 |
Activatable imaging probes with amplified fluorescent signals. | Current optical imaging probe applications are hampered by poor sensitivity and specificity to the target, but molecular-level fluorescent signal activation strategies can efficiently overcome these limitations. Recent interdisciplinary research that couples the imaging sciences to fluorophore, peptide, polymer, and in... | 18,802,536 |
Diol-substituted boron complexes of dipyrrolyl diketones as anion receptors and covalently linked 'pivotal' dimers. | Diol-substitution at a boron unit results in the formation of anion receptors consisting of dipyrrolyl diketones and covalently linked dimers, which exhibit selective binding for dianions with appropriate lengths. | 18,802,545 |
Ni(II)-catalyzed enantioselective Nazarov cyclizations. | Nazarov cyclizations are catalyzed by a dicationic Ni(II) complex containing the chiral tridentate phosphine Pigiphos; the catalyst exerts a high degree of torquoselectivity and affords the products in up to 88% ee. | 18,802,555 |
Unusual temperature dependence of salt effects for "on water" Wittig reaction: hydrophobicity at the interface. | An unusual variation with temperature of the salt effects in aqueous Wittig reaction is observed, suggesting that hydrophobic acceleration of reactions comprising "on water" reactants is fundamentally different from that for reactions with small non-polar solutes. | 18,802,585 |
Ultra stable ordered mesoporous phenol/formaldehyde polymers as a heterogeneous support for vanadium oxide. | Ordered mesoporous phenol/formaldehyde polymers are presented as an ultra stable heterogeneous support for vanadium oxide. | 18,802,595 |
Extraction behavior of lanthanides using a diglycolamide derivative TODGA in ionic liquids. | Liquid-liquid extraction of lanthanides from aqueous solutions into ionic liquids (ILs) has been investigated using N,N,N',N'-tetra(n-octyl)diglycolamide (TODGA) as an extractant, and compared with that in the isooctane system. Application of ILs as the extracting phase provided unprecedented enhancement of the extract... | 18,802,624 |
Amine and ammonium functionalization of chloromethylsilane-ended dendrimers. Antimicrobial activity studies. | Novel amine- and ammonium-terminated carbosilane dendrimers of type G(n)-[Si{CH(2)O-(C(6)H(4))-3-NMe(2)}](x) or G(n)-[Si{CH(2)O-(C(6)H(4))-3-NMe(3)(+)I(-)}](x) have been synthesized and characterized up to second generation by phenolysis of (chloromethyl)silyl-terminated dendrimers with 3-dimethylamine phenol and subse... | 18,802,631 |
Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4. | Tetra-acylated lipid As derived from Porphyromonas gingivalis LPS have been synthesized using a key disaccharide intermediate functionalized with levulinate (Lev), allyloxycarbonate (Alloc) and anomeric dimethylthexylsilyl (TDS) as orthogonal protecting groups and 9-fluorenylmethoxycarbamate (Fmoc) and azido as amino p... | 18,802,645 |
Lithium dilution cardiac output measurement in the critically ill patient: determination of precision of the technique. | Lithium dilution cardiac output by LiDCOplus (LiDCO, Cambridge, UK) is a validated methodology for measuring cardiac output. It is used to calibrate a pulse pressure analysis algorithm (PulseCO) for the continuous measurement of subsequent changes in this variable. The variability of measurements, or precision, within ... | 18,802,681 |
Chronic sleep disorders in survivors of the acute respiratory distress syndrome. | Sleep disruption is well recognized in the Intensive Care Unit. Poor sleep quality likely continues following discharge from hospital in several patients and becomes a chronic disorder in some. The aim of this study was to describe the etiology of chronic sleep complaints in survivors of ARDS. Seven ARDS survivors with... | 18,802,684 |
Hyper production of cellulase-free xylanase by Thermomyces lanuginosus SSBP on bagasse pulp and its application in biobleaching. | A cellulase-free xylanase production by Thermomyces lanuginosus SSBP using bagasse pulp was examined under submerged (SmC) and solid-state cultivation (SSC). Higher level of xylanase activity (19,320 +/- 37 U g(-1) dried carbon source) was obtained in SSC cultures than in SmC (1,772 +/- 15 U g(-1) dried carbon source) ... | 18,802,693 |
Cloning and functional characterization of a complex endo-beta-1,3-glucanase from Paenibacillus sp. | A beta-1,3-glucanase gene, encoding a protein of 1,793 amino acids, was cloned from a strain of Paenibacillus sp. in this study. This large protein, designated as LamA, consists of many putative functional units, which include, from N to C terminus, a leader peptide, three repeats of the S-layer homologous module, a ca... | 18,802,694 |
Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia. | Recent studies have demonstrated expression of Fc receptor-like (FCRL) molecules, a newly identified family with preferential B-cell lineage expression, in some chronic B-cell leukemias with possible implication for classification and/or targeted immunotherapy. In this study, the expression pattern of FCRL1-5 genes was... | 18,802,695 |
Paclitaxel reduces regulatory T cell numbers and inhibitory function and enhances the anti-tumor effects of the TLR9 agonist PF-3512676 in the mouse. | The anti-tumor properties of Toll-like receptor (TLR) 9 agonist CpG oligodeoxynucleotides (ODN) are enhanced by combinations with several cytotoxic chemotherapy regimens. The mechanisms of this added benefit, however, remain unclear. We now report that, similar to the depletion of regulatory T cells (Treg) using anti-C... | 18,802,696 |
High expression of PGE2 enzymatic pathways in cervical (pre)neoplastic lesions and functional consequences for antigen-presenting cells. | Although human papillomavirus (HPV) DNA is detected in the majority of squamous intraepithelial lesions (SIL) and carcinoma (SCC) of the uterine cervix, the persistence or progression of cervical lesions suggest that viral antigens are not adequately presented to the immune system. This hypothesis is reinforced by the ... | 18,802,697 |
Dermatomyositis associated with hepatitis B virus-related hepatocellular carcinoma. | Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) with typical cutaneous manifestations. It has been proposed that DM may be caused by autoimmune responses to viral infections, and previous studies have also shown that an association between DM and malignancy. However, chronic hepatitis B virus (HBV) in... | 18,802,699 |
Drug resistance and genetic mapping in Plasmodium falciparum. | Drug resistance in malaria parasites is a serious public health burden, and resistance to most of the antimalarial drugs currently in use has been reported. A better understanding of the molecular mechanisms of drug resistance is urgently needed to slow or circumvent the spread of resistance, to allow local treatments ... | 18,802,698 |
Tissue expression pattern of class II and class V genes found in the Adh complex on mouse chromosome 3. | The alcohol dehydrogenase enzymes in mice and humans are encoded by a linked group of genes in the same transcriptional orientation. The enzymes play important roles in alcohol metabolism and retinoid signaling and homeostasis. The expression patterns at the mRNA level of the mouse Adh4 (class II) gene and the recently... | 18,802,746 |
The influence of a toxic cyanobacterial bloom and water hydrology on algal populations and macroinvertebrate abundance in the upper littoral zone of Lake Krugersdrift, South Africa. | The biological interactions and the physical and chemical properties of the littoral zone of Lake Krugersdrift were studied for a 4-month period when a dense, toxic cyanobacterial bloom dominated by Microcystis aeruginosa was present in the main lake basin. The presence of a toxic strain of M. aeruginosa was confirmed ... | 18,802,748 |
Protein kinase C regulates the expression of M1 receptors and BDNF in rat retinal cells. | Protein kinase C (PKC) plays a key role in cellular events including proliferation, survival and differentiation. Our previous study showed the effect of phorbol 12-myristate 13-acetate (PMA), a PKC activator, inducing a decrease in retinal cells proliferation. This effect was mediated by muscarinic type 1 receptors (M... | 18,802,750 |
Immunocytochemical detection of neuronal NO synthase in rat brain cells. | The aims of the present work were to identify the neuronal form of nitric oxide synthase (nNOS type I) in brain structures in rats by immunocytochemistry, to compare the results with data from histochemical reactions for NADPH-diaphorase, and to develop the optimal conditions for fixation for detecting nNOS. The produc... | 18,802,756 |
Experience in the use of Actovegin in the treatment of patients with cognitive disorders in the acute period of stroke. | Forty-three patients with mild-moderate ischemic stroke were studied in the acute period and were divided into two groups. The experimental group consisted of 32 patients who were given Actovegin; the reference group consisted of 11 patients who were given piracetam. Patients were investigated before treatment and at 1... | 18,802,768 |
Immunohistochemical study concerning the origin of neurocytoma--a case report. | A 26-year-old woman presented with rapid tumor growth in her left frontal lobe during 9 years of observation. Operative findings revealed a massive tumor connected to gelatinous, transparent membranous tissue (MT), which extended from the paraventricular zone and continued into the lateral ventricle. Histological diagn... | 18,802,789 |
Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis. | Prostate-specific membrane antigen (PSMA) is a transmembrane protein that is overexpressed in advanced stage prostate adenocarcinomas. As a novel target for in vivo prognostic and therapeutic approaches, the distribution pattern of PSMA in primary and metastatic tumors is of significant interest. In this study we addre... | 18,802,790 |
Haplotypic diversity within the ovine calpastatin (CAST) gene. | Calpastatin (CAST) is a protein inhibitor that acts specifically on calpains and plays a regulatory role in postmortem beef tenderization and muscle proteolysis. Polymorphisms in the bovine CAST gene have been associated with meat tenderness, but little is known about how the ovine CAST gene may affect sheep meat quali... | 18,802,795 |
[Frontotemporal lobar degeneration: a descriptive study of 42 patients]. | Frontotemporal lobar degeneration (FTLD) is considered to be the second cause of presenile dementia. In spite of the great interest it has generated over the last few years, few studies have been published in our country. A descriptive retrospective study of 42 patients with FTLD evaluated in our unit during the period... | 18,802,798 |
Healing diabetic foot ulcers using cortical bone fenestration and cell therapy. | Chronic wounds with exposed bone present a challenge for clinicians. Without intact periosteum, cortical bone is relatively avascular and provides a poor base for wound healing and skin grafting. It has been shown that cortical bone fenestration and decortication can expedite wound healing in exposed calvarial bone. We... | 18,802,886 |
Creative limb-salvage surgical and endovascular revascularization strategies in treating critical limb ischemia. | Critical limb ischemia (CLI) is implicated in cases of between 220,000 to 240,000 amputations in the United States and Europe annually. Over the last five years, great technical strides have been made in both the surgical and nonsurgical endovascular treatments of CLI. This chapter analyzes and highlights those creativ... | 18,802,888 |
A long-survived case with solitary splenic metastasis from ovarian carcinoma. | A61-year-old postmenopausal woman with ovarian carcinoma was treated with two surgical operations and a series of platinum-based chemotherapy. A solitary metastasis into the splenic parenchyma was identified 33 months after the second surgery by abdominal computed tomography with an increased serum level of CA-125. She... | 18,802,901 |
Evaluation of the accuracy of three CT-free surgical navigation systems in total knee arthroplasty (TKA) using a coordinate measuring machine. | Previous studies have shown that the accuracy of computer-assisted surgery (CAS) via computed tomography (CT) free systems is useful when applied in the clinical realm. However, few studies have compared CAS systems to the current gold standard, manually applied measuring guides. Thirty total knee arthroplasties (TKA) ... | 18,802,908 |
Restoration of function in complete spinal cord injury using peripheral nerve rerouting: a summary of procedures. | Until relatively recently, few procedures have been developed that restore significant motor and sensory function in individuals with obsolete (ie, chronic), complete spinal cord injury (SCI). Building upon the methodology used to treat brachial root avulsion, the authors have developed peripheral nerve-rerouting proce... | 18,802,915 |
Focus on HTR2C: A possible suggestion for genetic studies of complex disorders. | HTR2C is one of the most relevant and investigated serotonin receptors. Its role in important brain structures such as the midbrain, the lateral septal complex, the hypothalamus, the olfactory bulb, the pons, the choroid plexus, the nucleus pallidus, the striatum and the amygdala, the nucleus accumbens and the anterior... | 18,802,918 |
Identification of a novel mutation in DKC1 in dyskeratosis congenita. | Dyskeratosis congenita (DC) is a rare congenital syndrome characterized by the triad of reticular skin pigmentation, nail dystrophy and mucosal leukoplakia, and the predisposition to bone marrow failure and malignancy. DC is genetically heterogeneous and X-linked and autosomal forms of the disease exist. Here, we repor... | 18,802,941 |
Behavioral and nutritional factors and geohelminth infection among two ethnic groups in the Terai region, Nepal. | Geohelminthiasis is a major health problem in many developing countries. This study was designed to evaluate the role of behaviors and the nutritional status of people with geohelminth infection in two indigenous ethnic groups in lowland Terai, Nepal. One hundred and fourteen individuals (55 Mushar and 59 Tharu) aged 2... | 18,802,944 |
Clinical characteristics and outcome of children with Burkitt lymphoma in Uganda according to HIV infection. | Characteristics of children with Burkitt lymphoma (BL) and HIV infection have not been described in Uganda before. We reviewed records at Uganda Cancer Institute (UCI) for years 1994-2004, to compare clinical features and outcome of BL in children who are HIV positive and negative (HIV+, HIV-). As statistical methods w... | 18,802,952 |
Phenotypic analyses of a medaka mutant reveal the importance of bilaterally synchronized expression of isthmic fgf8 for bilaterally symmetric formation of the optic tectum. | Developing neural tubes are bilaterally symmetric in all vertebrate embryos, irrespective of the presence of gene networks that generate left-right asymmetry. To explore the mechanisms that underlie the bilaterally symmetric formation of the neural tube, we examined a medaka (Oryzias latipes) dominant mutant, Oot, the ... | 18,802,954 |
DFT calculations as a powerful technique to probe the crystal structure of Al(acac)3. | (27)Al, (17)O and (13)C chemical shieldings of aluminum acetylacetonate complex, Al(acac)(3), were calculated at some Density Functional Theory (DFT) levels of theory. In these calculations the X-ray structures of its different polymorphs were used. Using these calculated data observed discrepancies between the X-ray c... | 18,802,968 |
[Role of duodenum in regulation of plasma ghrelin level and body mass index after subtotal gastrectomy]. | To investigate the role of duodenum in regulation of ghrelin and body mass index (BMI) and the correlation between ghrelin and BMI after subtotal gastrectomy. Forty-two patients with T(0-1)N(0-1)M(0) gastric cancer were divided into two groups after gastrectomy according to digestive reconstruction pattern, Billroth I ... | 18,803,044 |
[Effects of phosphatase of regenerating liver cell-3 gene silence by RNA interference on the expression of matrix metalloproteinases-2,-9 in human colon cancer cells]. | To explore the effects and associated mechanism of phosphatase of regenerating liver cell-3 (PRL-3) on the invasion of human colon cancer cell. After colon cancer cell line HCT116 was transfected with PRL-3 small interfering RNA (siRNA), the mRNA and protein expression of PRL-3 and matrix metalloproteinase 2 (MMP-2) an... | 18,803,055 |
Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose. | Adverse effects to N-acetylcysteine (NAC) are well recognized, but their etiology and incidence are unclear. The nature and severity of adverse effects were prospectively studied in 169 patients and potential reaction mediators studied in 22 patients. Adverse effects were minimal in 101 (59.8%), moderate in 51 (30.2%),... | 18,803,085 |
Evaluation of the patterns of potentially toxic exposures in Mississippi following Hurricane Katrina. | To describe the changes in the frequency of selected toxic exposures reported to the state poison control center following Hurricane Katrina. The numbers of selected exposures reported to the Mississippi Poison Control Center at 0-2 weeks, 3-4 weeks, and 5-12 weeks following Hurricane Katrina were compared to those for... | 18,803,086 |
Energy cost and mechanical efficiency of riding a human-powered recumbent bicycle. | When dealing with human-powered vehicles, it is important to quantify the capability of converting metabolic energy in useful mechanical work by measuring mechanical efficiency. In this study, net mechanical efficiency (eta) of riding a recumbent bicycle on flat terrain and at constant speeds (v, 5.1-10.0 m/s) was calc... | 18,803,095 |
Wrist strength is dependent on simultaneous power grip intensity. | The effect of grip activities on wrist flexion/extension strength was examined. Twelve healthy subjects performed maximum wrist flexion/extension exertions with one of five levels of simultaneous grip effort: minimum effort; preferred effort; 30%, 60% and 100% maximum voluntary contraction. As grip force increased from... | 18,803,097 |
Pharmacologic treatment of disturbed sleep in the elderly. | Disturbed sleep is common in the elderly, who, as a group, take a disproportionately large number of hypnotic medications. Benzodiazepine hypnotics, as well as the newer benzodiazepine receptor agonists, are the primary treatments for these late-life sleep disorders and are effective and safe when used within recommend... | 18,803,102 |
Impact of repeated pesticide applications on the binding and release of methyl 14C-monocrotophos and U-ring labelled 14C-carbaryl to soil matrices under field conditions. | The dissipation of (O-methyl-14C) monocrotophos and U-ring labelled 14C-carbaryl was monitored for over two years in absence and presence of other insecticides using in situ soil columns. The dissipation of 14C-monocrotophos from soil treated with methomyl and carbaryl showed a faster rate of downward movement than in ... | 18,803,114 |
Obtundation and seizure following ondansetron overdose in an infant. | Ondansetron, an increasingly prescribed 5-HT(3) antagonist used in the management of nausea and vomiting of various etiologies, has a well-established safety profile in therapeutic use. However, little is known about its effects in the setting of an overdose. We describe the first case of severe toxicity in an infant w... | 18,803,119 |
[Agreement among ophthalmologists and primary care physicians in the evaluation of retinographies of diabetic patients]. | To assess the extent of agreement in the evaluation of non-mydriatic retinographies of diabetic patients among ophthalmologists and a group of primary care physicians with previous training. The study was divided in two phases. In the first phase, the four participants were instructed in the interpretation of retinogra... | 18,803,124 |
[The social and familial dimension: experiences of caregivers and people with multiple sclerosis. The GEDMA study]. | Comparing the perceptions of multiple sclerosis (MS) patients and caregivers with regard to the same social and familial issues, as well as delving deeper into the factors that determine the quality of life of these patients and their relatives by using a qualitative methodology, can help us to complete the information... | 18,803,152 |
[Anatomical and neurochemical bases accounting for the frequent association between headaches and sleep: the hypnic headache paradigm]. | The relationship between headache and sleep is complex and runs in two directions. Headache may be the consequence of a (primary or secondary) sleep disorder or its cause (in chronic tension-type headache and/or chronic migraine with or without painkiller abuse). It can also be related to sleep in an intrinsic way, as ... | 18,803,160 |
A method for rapidly predicting drug tissue distribution using surfactant vesicle electrokinetic chromatography. | Lung tissue distribution of an inhaled drug is important for its potency in the airways and with minimum systemic effects within its dose range. As the lung has the smallest diffusion distance of all the organs in the body and negligible diffusion delays, the characteristics of drug distribution in the lung will mainly... | 18,803,182 |
Ruthenium complexes of substituted hydrazine: new solution- and solid-state binding modes. | The methylhydrazine complex [Ru(NH(2)NHMe)(PyP)(2)]Cl(BPh(4)) (PyP=1-[2-(diphenylphosphino)ethyl]pyrazole) was synthesised by addition of methylhydrazine to the bimetallic complex [Ru(mu-Cl)(PyP)(2)](2)(BPh(4))(2). The methylhydrazine ligand of the ruthenium complex has two different binding modes: side-on (eta(2)-) wh... | 18,803,189 |
Theoretical study of the human bradykinin-bradykinin B2 receptor complex. | The interaction of bradykinin (BK) with the bradykinin B2 receptor (B2R) was analyzed by using molecular modeling (MM) and molecular dynamics (MD) simulations. A homology model for B2R has been generated and the recently determined receptor-bound solid-state NMR spectroscopic structure of BK (Lopez et al., Angew. Chem.... | 18,803,210 |
Cyclodextrin-based nonaqueous electrokinetic chromatography with UV and mass spectrometric detection: application to the impurity profiling of amiodarone. | The potential of nonaqueous electrokinetic chromatography (NAEKC) using cyclodextrins (CD) for the analysis of basic drugs and related compounds was evaluated. Both UV absorbance and mass spectrometric (MS) detection were employed. Addition of neutral CD to the NA background electrolyte did not significantly enhance th... | 18,803,218 |
Electrophoresis studies on the contaminating glycosaminoglycans in commercially available hyaluronic acid products. | Hyaluronic acid (HA) samples showing inhibition effect on digestion with testicular hyaluronidase (HAase) were found from 16 commercially available HA products, which were supplied from 11 different manufacturers. Most of these HA samples (six samples) were derived from the rooster comb, and one sample was derived from... | 18,803,225 |
In vitro differentiation of human calvarial suture derived cells with and without dexamethasone does not induce in vivo-like expression. | Osteogenic supplements are a requirement for osteoblastic cell differentiation during in vitro culture of human calvarial suture-derived cell populations. We investigated the ability of ascorbic acid and beta-glycerophosphate with and without the addition of dexamethasone to stimulate in vivo-like osteoblastic differen... | 18,803,234 |
Wnt/Frizzled family members mediate olfactory sensory neuron axon extension. | A comprehensive model has yet to emerge, but it seems likely that numerous mechanisms contribute to the specificity of olfactory sensory neuron (OSN) axon innervation of the olfactory bulb. Elsewhere in the nervous system the Wnt/Fz family has been implicated in patterning of anterior-posterior axes, cell type specific... | 18,803,244 |
Normal blood cells reference intervals of healthy adults at the Gaza Strip-Palestine. | Hematological parameters are affected by different factors that include age, sex, smoking, ethnicity, and environmental altitude. It has been justified that each population must establish its own normal reference intervals to be used in clinical assessments and interpretations. Hematological reference intervals for adu... | 18,803,270 |
Comparative evaluation of FASTPlaque assay with PCR and other conventional in vitro diagnostic methods for the early detection of pulmonary tuberculosis. | Rapid and accurate diagnosis of symptomatic patients of pulmonary tuberculosis (TB) is highly desirable to minimize the spread of the disease in the society. We, therefore, compared the usefulness of various conventional diagnostic methods, the in-house polymerase chain reaction (PCR), and the FASTPlaque assay in this ... | 18,803,271 |
Flow cytometric quantitation of natural killer cells and T lymphocytes expressing T-cell receptors alpha/beta and gamma/delta is not helpful in distinguishing benign from malignant body cavity effusions. | Quantitation of natural killer (NK) cells in benign and malignant effusions has yielded conflicting results in the past. Studies have claimed higher, lower, and essentially equal percentages of NK cells for benign and malignant effusions. In addition, virtually no literature exists on the numbers and distribution of T ... | 18,803,280 |
NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens. | While glial cells are recognized for their roles in maintaining neuronal function, there is growing appreciation that resident central nervous system (CNS) cells initiate and/or augment inflammation following trauma or infection. We have recently demonstrated that microglia and astrocytes constitutively express nucleot... | 18,803,303 |
Biology and pathology of nonmyelinating Schwann cells. | The CNS contains relatively few unmyelinated nerve fibers, and thus benefits from the advantages that are conferred by myelination, including faster conduction velocities, lower energy consumption for impulse transmission, and greater stability of point-to-point connectivity. In the PNS many fibers or regions of fibers... | 18,803,315 |
Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease. | In this article we first discuss the factors that regulate macrophage recruitment, activation, and myelin phagocytosis during Wallerian degeneration and some of the factors involved in the termination of inflammation at the end of the period of Wallerian degeneration after peripheral nerve injuries. In particular, we d... | 18,803,324 |
Detecting signals of opioid analgesic abuse: application of a spatial mixed effect poisson regression model using data from a network of poison control centers. | The recent rise in the non-medical use of opioid analgesics in the US has underscored the importance of comprehensive post-marketing surveillance of these products. To assist pharmacovigilance efforts, we developed a methodology for detecting geo-specific "signals" of potential outbreaks of prescription drug abuse by 3... | 18,803,336 |
An integrated system for planning, navigation and robotic assistance for skull base surgery. | We developed an image-guided robot system to provide mechanical assistance for skull base drilling, which is performed to gain access for some neurosurgical interventions, such as tumour resection. The motivation for introducing this robot was to improve safety by preventing the surgeon from accidentally damaging criti... | 18,803,337 |
Weight loss and isotopic shifts for water drops frozen on a liquid nitrogen surface. | A liquid nitrogen freezing method was used to collect raindrops for the determination of isotope-size distribution. Water drops that fall onto a surface of liquid nitrogen stay suspended for 10 to 20 s, until their temperature reaches the Leidenfrost point (126 K). As their temperature falls to the freezing point, they... | 18,803,342 |
Enrichment of low molecular weight serum proteins using acetonitrile precipitation for mass spectrometry based proteomic analysis. | A rapid acetonitrile (ACN)-based extraction method has been developed that reproducibly depletes high abundance and high molecular weight proteins from serum prior to mass spectrometric analysis. A nanoflow liquid chromatography/tandem mass spectrometry (nano-LC/MS/MS) multiple reaction monitoring (MRM) method for 57 h... | 18,803,344 |
Biological impact of hepatitis B virus X-hepatitis C virus core fusion gene on human hepatocytes. | To investigate the biological impact of hepatitis B virus X- hepatitis C virus core (HBV X-HCV C) fusion gene on hepatoma cells. The recombinant adenoviruses Ad-XC, Ad-X and Ad-C expressing HBV X-HCV C fusion gene, HBV X gene and HCV C gene were constructed, respectively. Hepatoma cells were infected with different rec... | 18,803,352 |
"Rescue" regimens after Helicobacter pylori treatment failure. | Helicobacter pylori (H pylori) infection is the main cause of gastritis, gastroduodenal ulcer disease, and gastric cancer. After more than 20 years of experience in H pylori treatment, in my opinion, the ideal regimen to treat this infection is still to be found. Currently, apart from having to know first-line eradicat... | 18,803,350 |
Is there a role for Tc-99m (V) DMSA scintigraphy in ischemic colitis? | To evaluate the role of pentavalent Tc-99m dimercaptosuccinic acid [Tc-99m (V) DMSA] in the diagnosis of ischemic colitis. Fourteen patients with endoscopically and histologically confirmed ischemic colitis were included in the study. Tc-99m (V) DMSA scintigraphy was performed within 2 d after colonoscopy. Images were ... | 18,803,355 |
Development of autoimmune hepatitis type 1 after pulsed methylprednisolone therapy for multiple sclerosis: a case report. | A 43-year-old woman with multiple sclerosis (MS) was treated with pulsed methylprednisolone and interferon beta at a hospital. Four weeks after initiating treatment, liver dysfunction occurred and she was referred and admitted to our hospital. Clinical and laboratory findings were consistent with and fulfilled the crit... | 18,803,363 |
Self-assembly of alpha-helical coiled coil nanofibers. | The alpha-helical coiled coil is one of the best-studied and most well-understood protein folding motifs. In particular, the coiled coil can be made to self-assemble into a nanofibrous architecture with many potential applications in biomimetic engineering and elsewhere. The key to the assembly of such nanofibers has b... | 18,803,383 |
From a paramagnetic, mononuclear supersulfidonickel(II) complex to a diamagnetic dimer with a four-sulfur two-electron bond. | The first isolable "side-on" supersulfidonickel(II) complex 1(1) with the elusive S2-. ligand has been synthesized by facile oxidation of the corresponding nickel(I) precursor [LNi] with elemental sulfur. Remarkably, paramagnetic 1(1) associates voluntarily to give the diamagnetic dimer 1(2) with a four-sulfur two-elec... | 18,803,388 |
E113 is required for the efficient photoisomerization of the unprotonated chromophore in a UV-absorbing visual pigment. | Protonation of the retinal Schiff base chromophore is responsible for the absorption of visible light and is stabilized by the counterion residue E113 in vertebrate visual pigments. However, this residue is also conserved in vertebrate UV-absorbing visual pigments (UV pigments) which have an unprotonated Schiff base ch... | 18,803,408 |
Quantum-interference-controlled molecular electronics. | Quantum interference in coherent transport through single molecular rings may provide a mechanism to control the current in molecular electronics. We investigate its applicability, using a single-particle Green function method combined with ab initio electronic structure calculations. We find that the quantum interfere... | 18,803,424 |
Oxygen consumption during functional electrical stimulation-assisted exercise in persons with spinal cord injury: implications for fitness and health. | A lesion in the spinal cord leads in most cases to a significant reduction in active muscle mass, whereby the paralysed muscles cannot contribute to oxygen consumption (VO2) during exercise. Consequently, persons with spinal cord injury (SCI) can only achieve high VO2 values by excessively stressing the upper body musc... | 18,803,435 |
Paclitaxel and docetaxel in the treatment of breast cancer. | Paclitaxel and docetaxel are considered fundamental drugs in the treatment of breast cancer. To review the current role of taxanes in the treatment breast cancer, with emphasis on data from randomized trials comparing the two taxanes. We have reviewed the available evidence in the literature to gauge the results of the... | 18,803,448 |
Pharmacoeconomics of entecavir treatment for chronic hepatitis B. | Entecavir is a new antiviral agent for chronic hepatitis B virus (HBV) infection with potent HBV suppression and a low rate of viral resistance. To review published studies on the pharmacoeconomics of entecavir for treatment of chronic HBV. A literature search on Medline and Embase over the period of 1998 - 2008 was pe... | 18,803,453 |
Mitiglinide: a rapid- and short-acting non-sulfonylurea insulinotropic agent for the treatment of type 2 diabetic patients. | This review article deals with mitiglinide, a rapid-acting non-sulfonylurea insulinotropic agent for the treatment of type 2 diabetic patients. Attention is drawn to the background history of mitiglinide, its chemistry, its determination in plasma, its metabolic pathway, preclinical investigations conducted - either in... | 18,803,455 |
Dynamic intracellular distribution of Eaf2 and its potential involvement in UV-Induced DNA damage response. | Eaf2 encodes a tumor suppressor that plays multiple functions in transcriptional activation, apoptosis, and embryonic development. In this study, we utilized GFP-EAF2 fusion protein to describe the dynamic subcellular movement of Eaf2. GFP-EAF2 is preferentially localized to the nucleus, and in the presence of ELL, it ... | 18,803,460 |
Carotid angioplasty and stenting under protection: advantages and drawbacks. | Carotid stenosis is responsible for approximately 30% of strokes, and carotid endarterectomy is considered to be the gold-standard treatment. Carotid angioplasty and stenting (CAS) has been proposed as an alternative to surgery but the risk of neurological complications and brain embolism remains the major drawback to ... | 18,803,470 |
Strategies and applications for incorporating physical and chemical signal gradients in tissue engineering. | From embryonic development to wound repair, concentration gradients of bioactive signaling molecules guide tissue formation and regeneration. Moreover, gradients in cellular and extracellular architecture as well as in mechanical properties are readily apparent in native tissues. Perhaps tissue engineers can take a cue... | 18,803,499 |
Rabies in China: an update. | Human rabies cases in China have continued to increase in recent years, reaching a new peak in 2007. Parallel with an increase in human rabies deaths, a number of animal species with rabies have been reported in the majority of rabies-endemic areas. In this report, the occurrence, status, and control of rabies in both ... | 18,803,503 |
Generation and characterization of monoclonal antibodies to mTOR kinase. | Abstract Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays a critical role in the regulation of basic cellular functions, including cellular growth and proliferation. In this study we describe the generation and characterization of novel monoclonal antibodies directed against mTOR protein kin... | 18,803,507 |
Laparoscopic total extraperitoneal inguinal hernia repair under spinal anesthesia: a study of 480 patients. | Laparoscopic total extraperitoneal inguinal hernia repair (TEP) is conventionally performed under general anesthesia (GA), and regional anesthesia is usually preferred in patients where GA is contraindicated. In this paper, we present our experience of over 8 years of using spinal anesthesia (SA) as the first choice wi... | 18,803,509 |
A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trial. | To determine whether a 5-day course of oral prednisolone is superior to a 3-day course in reducing the 2-week morbidity of children with asthma exacerbations who are not hospitalised. Double-blind randomised controlled trial of asthma outcomes following a 5-day course of oral prednisolone (1 mg/kg) compared with a 3-da... | 18,803,532 |
High levels of confusion for cholesterol awareness campaigns. | Earlier this year, two industry-sponsored advertising campaigns for cholesterol awareness that target the general public were launched in Australia. These campaigns aimed to alert the public to the risks associated with having high cholesterol and encouraged cholesterol testing for wider groups than those specified by ... | 18,803,537 |
The viability of Australia's teaching hospitals. | In a now diverse range of teaching hospitals striving to excel, excellence in research should be prioritised. | 18,803,538 |
Noncontact mapping of the heart: how and when to use. | The noncontact mapping system is a new tool for electrophysiologic study and radiofrequency ablation. The mode of operation includes single beat, three-dimensional, high-density mapping. Careful analysis of unipolar electrograms and isopotential maps are essential to understand the mechanism of the arrhythmia. Radiofre... | 18,803,565 |
Description and phylogeny of Ceratomyxa anko sp. n. and Zschokkella lophii sp. n. from the Japanese anglerfish, Lophius litulon (Jordan). | Two new species of myxozoans from the Japanese anglerfish, Lophius litulon, are described using myxospore morphology and small subunit rDNA sequences. Ceratomyxa anko sp. n. is a parasite of the gall bladder and had a prevalence of 57%. Mature spores of C. anko sp. n. are arcuate to crescent shaped with valves tapering... | 18,803,583 |
The effects of water velocity on the Ceratomyxa shasta infectious cycle. | Ceratomyxa shasta is a myxozoan parasite identified as a contributor to salmon mortality in the Klamath River, USA. The parasite has a complex life cycle involving a freshwater polychaete, Manayunkia speciosa and a salmonid. As part of ongoing research on how environmental parameters influence parasite establishment an... | 18,803,584 |
Gene expression profile of Huh-7 cells expressing hepatitis C virus genotype 1b or 3a core proteins. | The liver disease expression in chronic hepatitis C patients is variable and may partially depend on the sequence of the infecting viral genotype. To identify some hepatitis C virus (HCV) genotype-specific virus-host interactions potentially leading to clinically significant consequences. We compared the gene expressio... | 18,803,589 |
Neural mechanisms underlying the processing of Chinese and English words in a word generation task: an event-related potential study. | Event-related brain potentials (ERPs) were used to examine the spatiotemporal cortical activation patterns underlying Chinese and English word generation (forming a new word by adding a stroke or a letter to an old Chinese or English word) for low- and high-proficiency Chinese-English bilinguals. The results revealed t... | 18,803,601 |
High frequency jet ventilation through the laryngeal mask airway in a critically obstructed airway. | A 72 year-old man with an anticipated difficult airway secondary to a large, obstructing supraglottic tumour was scheduled for a panendoscopy. An elective pre-induction transtracheal catheter was placed to allow oxygenation if airway maintenance proved difficult. Following induction of anaesthesia, tracheal intubation ... | 18,803,629 |
Tympanic ossicles and pharyngeal arches. | We have performed a study on 11 human embryos regarding the development of the tympanic ossicles and their relationship with the first pharyngeal arch. After performing measurements to date the embryos and foetuses chronologically, we performed a meticulous dissection of the temporal bones. Subsequently, they were fixe... | 18,803,631 |
CT-soft tissue window of the cranial abdomen in clinically normal dogs: an anatomical description using macroscopic cross-sections with vascular injection. | The aim of this study was to provide a detailed anatomic atlas of the cranial abdomen by means of computed tomography (CT). Three mature dogs, all mixed breed males, were used. The dogs were sedated, anaesthetized and positioned in sternal recumbency. CT scans from the eighth thoracic vertebra to the fourth lumbar vert... | 18,803,632 |
Metformin suppresses intestinal polyp growth in ApcMin/+ mice. | Metformin is a biguanide derivative that is widely used in the treatment of diabetes mellitus. One of the pharmacological targets of metformin is adenosine monophosphate-activated protein kinase (AMPK). We investigated the effect of metformin on the suppression of intestinal polyp formation in Apc(Min/+) mice. Administ... | 18,803,638 |
Extended NO analysis in a healthy subgroup of a random sample from a Swedish population. | There is an interest in modelling exhaled nitric oxide (NO). Studies have shown that flow-independent NO parameters i.e. NO of the alveolar region (C(A)NO), airway wall (C(aw)NO), diffusing capacity (D(aw)NO) and flux (J(aw)NO), are altered in several disease states such as asthma, cystic fibrosis, alveolitis and chron... | 18,803,639 |
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