title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Increased QT variability in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. | Although sudden death (SD) accounts for numerous cases of premature mortality in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the risk factors responsible for this dramatic event remain unclear. We sought possible differences in the QT variability i... | 18,803,652 |
Epilysin (MMP-28)--structure, expression and potential functions. | Epilysin (MMP-28) is the newest member of the matrix metalloproteinase (MMP) family of extracellular proteases. Together the MMPs can degrade almost all components of the extracellular matrix (ECM). MMPs also regulate cell behaviour by releasing growth factors and biologically active peptides from the ECM by modulating... | 18,803,661 |
Barriers to cross-fertilization between populations of a widely dispersed polychaete species are unlikely to have arisen through gametic compatibility arms-races. | Although there are theoretical reasons to suspect that gametic incompatibility may develop readily among populations of broadcast spawning marine invertebrates, there have been very few studies documenting geographic patterns of interpopulation incompatibility for any species. To address this we determined how successf... | 18,803,690 |
Pathogenic missense MAPT mutations differentially modulate tau aggregation propensity at nucleation and extension steps. | Mutations in the MAPT gene encoding tau protein lead to neurofibrillary lesion formation, neurodegeneration, and cognitive decline associated with frontotemporal lobar degeneration. While some pathogenic mutations affect MAPT introns, resulting in abnormal splicing patterns, the majority occur in the tau coding sequenc... | 18,803,694 |
Antioxidant effects of flavonoids used as food additives (purple corn color, enzymatically modified isoquercitrin, and isoquercitrin) on liver carcinogenesis in a rat medium-term bioassay. | To clarify the effects of purple corn color, enzymatically modified isoquercitrin (EMIQ), and isoquercitrin (IQ), registered as natural food additives in Japan, on liver carcinogenesis in vivo, a medium-term bioassay was employed. A total of 100 male F344 rats were divided into 5 groups; groups 1 to 4 were given a sing... | 18,803,703 |
People with mental disabilities negotiating life in the risk society: a theoretical approach. | Risk assessment and risk management owing to the potential threat from people with serious mental disorders living in the local community have been given much attention in psychiatric and mental healthcare research. Research connected to risks associated with living in the community for people with mental disabilities ... | 18,803,734 |
Seminal plasma proteins and sperm resistance to stress. | The role of seminal plasma (SP) in mammalian sperm function remains largely a matter of speculation as both inhibitory and stimulating effects have been found. Specific components of SP, particularly proteins, are adsorbed onto the surface of ejaculated sperm as they pass through the male and female reproductive tracts... | 18,803,753 |
Fate mapping in embryos of Neoceratodus forsteri reveals cranial neural crest participation in tooth development is conserved from lungfish to tetrapods. | Experimental evidence that the neural crest participates in tooth development in any osteichthyan fish has so far been lacking. Using vital dye cell-lineage tracking, we demonstrate that trigeminal stream neural crest cells contribute to the dental papilla of developing teeth in the Australian lungfish. Trigeminal neur... | 18,803,771 |
Application of individual increase in inbreeding to estimate realized effective sizes from real pedigrees. | The objective of this study was to test the performance of a recently proposed methodology for the estimation of realized effective size (N(e)) based on individual increase in inbreeding (DeltaF(i)) on several real pedigrees: (a) an experimental mice population; (b) a closed pedigree of fighting bulls; (c) the Spanish ... | 18,803,785 |
Evolutionary origins of novel conchologic growth patterns in tropical American corbulid bivalves. | We conducted a combined sclerochronologic and phylogenetic analysis to document patterns and rates of shell accretion in several subclades of related corbulids, and to explore the evolutionary origins of novel conchologic developmental patterns. We found three disparate patterns of valve development in Neogene tropical... | 18,803,781 |
Malaria case-management under artemether-lumefantrine treatment policy in Uganda. | Case-management with artemether-lumefantrine (AL) is one of the key strategies to control malaria in many African countries. Yet, the reports on translation of AL implementation activities into clinical practice are scarce. Here the quality of AL case-management is reported from Uganda; approximately one year after AL ... | 18,803,833 |
Posterior dislocation of the elbow associated with fracture of the radial head and olecranon, and with medial collateral ligament disruption: A case report. | Fracture dislocations of the elbow appear extremely complex. Identification of the basic injury patterns can facilitate management. A 38-year-old male motor-vehicle driver who fell on his right elbow after an accident was suffering from posterior dislocation of the elbow, without coronoid fracture, and with fracture of... | 18,803,834 |
The metagenomics RAST server - a public resource for the automatic phylogenetic and functional analysis of metagenomes. | Random community genomes (metagenomes) are now commonly used to study microbes in different environments. Over the past few years, the major challenge associated with metagenomics shifted from generating to analyzing sequences. High-throughput, low-cost next-generation sequencing has provided access to metagenomics to ... | 18,803,844 |
Transcriptional regulation of mouse alpha A-crystallin gene in a 148kb Cryaa BAC and its derivates. | alphaA-crystallin is highly expressed in the embryonic, neonatal and adult mouse lens. Previously, we identified two novel distal control regions, DCR1 and DCR3. DCR1 was required for transgenic expression of enhanced green fluorescent protein, EGFP, in lens epithelium, whereas DCR3 was active during "late" stages of l... | 18,803,847 |
Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia? | Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this cluster of schizophrenia-related endophenotypes was associated with abnormal neurogenesis in the adult hippocampus, ... | 18,803,858 |
Hfq regulates the expression of the thermostable direct hemolysin gene in Vibrio parahaemolyticus. | The hfq gene is conserved in a wide variety of bacteria and Hfq is involved in many cellular functions such as stress responses and the regulation of gene expression. It has also been reported that Hfq is involved in bacterial pathogenicity. However, it is not clear whether Hfq regulates virulence in Vibrio parahaemoly... | 18,803,872 |
Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. | MicroRNAs (miRNAs), some of which function as oncogenes or tumor suppressor genes, are involved in carcinogenesis via regulating cell proliferation and/or cell death. MicroRNA miR-34 was recently found to be a direct target of p53, functioning downstream of the p53 pathway as a tumor suppressor. miR-34 targets Notch, H... | 18,803,879 |
Factor XIII deficiency in children--clinical presentation and outcome. | To determine the demographic features and clinical outcome of children with Factor XIII deficiency. Observational case series. The Aga Khan University Hospital, Karachi, from January 1996 to December 2006. Records of all hospitalized pediatric patients with discharge diagnosis of FXIII D, on the basis of factor XIII as... | 18,803,895 |
Primary renal lymphoma. | A 62-year-old male patient presented with right flank pain and right renal mass on CT scan. Patient left against medical advice and had nephrectomy done elsewhere. Histopathology revealed a diffuse large cell B-cell lymphoma. Patient presented again, with disseminated disease and was started on chemotherapy. Although a... | 18,803,901 |
Quantitative electroencephalography and attention-deficit/hyperactivity disorder: implications for clinical practice. | Although behavioral symptoms of inattention, impulsivity, and hyperactivity serve as a foundation for the accurate diagnosis of attention-deficit/hyperactivity disorder (ADHD), the low interrater reliability and specificity of behavioral rating scales and the absence of comprehensive screening for medical conditions th... | 18,803,918 |
Parkinson disease: primacy of age as a risk factor for mitochondrial dysfunction. | In 1983, it was reported that certain drug users with a history of exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a contaminant of an illicitly produced meperidine analogue, developed an irreversible syndrome resembling idiopathic Parkinson disease (PD). Soon thereafter, 1-methyl-4-phenyl-1,2,3,6-tetrahydrop... | 18,803,967 |
Estimating the health benefits and costs associated with ezetimibe coadministered with statin therapy compared with higher dose statin monotherapy in patients with established cardiovascular disease: results of a Markov model for UK costs using data registries. | Ezetimibe has been reported to improve lipid control in patients with established cardiovascular disease (CVD). The aim of this study was to estimate the potential long-term impact on health status of prescribing ezetimibe in combination with statin therapy in patients with established CVD and evaluate its cost-effecti... | 18,803,993 |
Cervical myelopathy: a case report of a "near-miss" complication to cervical manipulation. | Cases have been reported in which radiculopathy or myelopathy secondary to herniated disk has occurred after cervical manipulation. In each case, it is not possible to determine whether the neurologic symptoms and signs were directly caused by the manipulation or whether they developed as part of the natural history of... | 18,804,007 |
Attention deficit/hyperactivity disorder: a review and update. | Attention deficit/hyperactivity disorder (ADHD) is a prevalent, chronic, and pervasive childhood disorder characterized by developmentally inappropriate activity level, impulsivity, and inability to sustain attention and concentration. Core symptoms of the disorder are associated with impairment in multiple domains of ... | 18,804,015 |
Enteral feeding in neurologically impaired children with gastroesophageal reflux: Nissen fundoplication and gastrostomy tube placement versus percutaneous gastrojejunostomy. | Parents or caregivers of neurologically impaired children with gastroesophageal reflux who require enteral nutrition are often faced with the option of having their child undergo an antireflux surgery and placement of a gastrostomy tube or have a percutaneous gastrojejunostomy tube placed under fluoroscopic guidance. I... | 18,804,022 |
Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones. | Mycolic acids are essential components of the mycobacterial cell wall. In this study, we show that a gene encoding a reductase involved in the final step of mycolic acid biosynthesis can be deleted in Mycobacterium smegmatis without affecting cell viability. Deletion of MSMEG4722 (ortholog of Mycobacterium tuberculosis... | 18,804,030 |
Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. | Human tissue transglutaminase (TGM2) is a calcium-dependent crosslinking enzyme involved in the posttranslational modification of intra- and extracellular proteins and implicated in several neurodegenerative diseases. To find specific inhibitors to TGM2, two structurally diverse chemical libraries (LOPAC and Prestwick)... | 18,804,034 |
Cell-based therapies for osteonecrosis of the femoral head. | Osteonecrosis of the femoral head is a disabling condition and a known complication of hematopoietic cell transplants (HCT). It is characterized by empty lacunae in the osseous matrix and necrotic marrow elements. The most important risk factor in HCT recipients is steroid exposure, frequently in the context of graft-v... | 18,804,037 |
Posttransplant autoimmune hemolytic anemia and other autoimmune cytopenias are increased in very young infants undergoing unrelated donor umbilical cord blood transplantation. | Autoimmune cytopenias are a recognized complication of hematopoietic stem cell transplant (HSCT), and are considered to be a feature of chronic graft-versus-host disease (cGVHD). We report on a cohort of very young infants (< or =3 months of age) receiving HSCT from unrelated donor umbilical cord blood for genetic d... | 18,804,040 |
Persistence of human parvovirus B19 in multipotent mesenchymal stromal cells expressing the erythrocyte P antigen: implications for transplantation. | Multipotent mesenchymal stromal cells (MSCs) are used to improve the outcome of hematopoietic stem cell transplantation (HCST) and in regenerative medicine. MSCs may harbor persistent viruses that may compromise their clinical benefit, however. Retrospectively screened, 1 of 20 MSCs from healthy donors contained parvov... | 18,804,048 |
Protein engineering on biphenyl dioxygenase for conferring activity to convert 7-hydroxyflavone and 5,7-dihydroxyflavone (chrysin). | A central part (amino-acid position 268-397 of 458 amino-acid residues) of the biphenyl dioxygenase large (alpha) subunit, BphA1, from Pseudomonas pseudoalcaligenes strain KF707 was exchanged with the corresponding part of BphA1 from another biphenyl-degrading bacterium, Pseudomonas putida strain KF715, to construct hy... | 18,804,053 |
CoCl(2) inhibits neural differentiation of retinoic acid-treated embryoid bodies. | The effects of CoCl(2) on retinoic acid (RA)-treated embryoid bodies (EBs) were investigated. Four-day EBs were treated with 5x10(-6) M of RA for 4 d, then subjected to attached culturing for 7 d in the presence of CoCl(2) at 0, 20, and 100 microM. Differentiation into MAP2- and GFAP-immunopositive cells was inhibited ... | 18,804,056 |
Ischemic brain cell-derived conditioned medium protects astrocytes against ischemia through GDNF/ERK/NF-kB signaling pathway. | Conditioned medium (CM) collected from cultures of ischemic microglia, astrocytes, and neurons were protective to astrocytes under the in vitro ischemic condition (deprivation of oxygen, glucose and serum). Molecular and signaling pathway(s) responsible for the CMs protective activity were investigated. Results showed ... | 18,804,095 |
Inflammatory pathways in malaria infection: TLRs share the stage with other components of innate immunity. | Severe forms of malaria infection claim over 1 million lives annually. One aspect of severe malaria pathogenesis is an excessive or dysregulated inflammatory response to infection. With the characterization of Toll-like receptors (TLRs), which initiate inflammation upon detection of microbial products, involvement of T... | 18,804,125 |
Kalopanaxsaponin A induces apoptosis in human leukemia U937 cells through extracellular Ca2+ influx and caspase-8 dependent pathways. | In the present study, we investigated the effect of KPS-A on the apoptotic activity and the molecular mechanism of the action in human leukemia. Treatment with KPS-A significantly increased apoptotic DNA fragmentation in human histiocytic lymphoma U937 cells as shown by DAPI staining, flow cytometry, and agarose gel el... | 18,804,143 |
The septal area, site for the central regulation of penile erection during waking and rapid eye movement sleep in rats: a stimulation study. | The effects of electrical stimulation to the septum on penile erections in rats were examined to clarify the mechanisms for regulation of erectile responses during different states of vigilance. Penile responses were assessed by changes in pressure in the corpus spongiosum of penis (CSP) and electromyography (EMG) of t... | 18,804,152 |
Rubratoxin B induces interleukin-6 secretion in mouse white adipose tissues and 3T3-L1 adipocytes. | Rubratoxin B is a mycotoxin that causes hepatic fatty changes. We examined whether white adipose tissue (WAT) contributes to rubratoxin B toxicity through effects on interleukin (IL)-6. Rubratoxin B was intraperitoneally injected into mice at 1.5mg/kg. Urinary albumin and macrophage inflammatory protein (MIP)-2 secreti... | 18,804,154 |
Tweaking biological switches through a better understanding of bistability behavior. | Many biological events are binary. The switch between mutually exclusive OFF to ON state in response to a stimulus is frequently mediated by a control circuit with a positive and/or a negative feedback. Such a system typically exhibits hysteresis with its switching ON and OFF stimulus levels dependent on the current st... | 18,804,166 |
Has nature already identified all useful antibacterial targets? | Novel antimicrobial targets are urgently needed to overcome rising antibiotic resistance of important human pathogens. However, evidence from previous antimicrobial screenings, in silico analysis, and experimental target evaluation suggests that the number of novel bacterial broad-spectrum targets might be severely lim... | 18,804,175 |
Sequential effects within a short foreperiod context: evidence for the conditioning account of temporal preparation. | Responses to an imperative stimulus (IS) are especially fast when they are preceded by a warning signal (WS). When the interval between WS and IS (the foreperiod, FP) is variable, reaction time (RT) is not only influenced by the current FP but also by the FP of the preceding trial. These sequential effects have recentl... | 18,804,193 |
New immunosuppressive approaches: oral administration of CD3-specific antibody to treat autoimmunity. | One of the major goals for the immunotherapy of autoimmune diseases is the induction of regulatory T cells that mediate immunologic tolerance. Parenteral administration of anti-CD3 monoclonal antibody is an approved therapy for transplantation in humans and is effective in autoimmune diabetes. We have found that oral a... | 18,804,221 |
Diagnostic accuracy of an initial azoospermic reading compared with results of post-centrifugation semen analysis after vasectomy. | Semen analysis is a common laboratory procedure but few data are available to support recommendations as to whether centrifugation is necessary in the post-vasectomy context. We evaluated the accuracy of a pre-centrifugation determination of azoospermia compared with post-centrifugation results. We conducted a secondar... | 18,804,227 |
Urinary symptoms before and after female urethral diverticulectomy--can we predict de novo stress urinary incontinence? | We assessed preoperative and postoperative urinary symptoms, and determined risk factors for de novo stress urinary incontinence after transvaginal urethral diverticulectomy. We reviewed the case records of 25 consecutive women who had transvaginal urethral diverticulectomy. Urinary symptoms were documented before and ... | 18,804,229 |
Coagulation dynamics of fractal flocs induced by enmeshment and electrostatic patch mechanisms. | The size and structure of flocs during floc formation were monitored for various coagulation mechanisms. Two distinctive mechanisms, namely, enmeshment and electrostatic patch, govern the dynamics of kaolin particles coagulation by polyaluminum chloride (PACl). They were investigated by small angle static light scatter... | 18,804,257 |
Influence of liming on metal sequestration in lake sediments over recent decades. | Sediment profiles from five limed and six reference softwater lakes included in Swedish monitoring programmes were subjected to multi-element analysis to investigate the influence of lime treatment since 1977 on the sequestration of metals in lake sediments. We hypothesised that liming causes increased sedimentation of... | 18,804,259 |
SPME-GCMS study of the natural attenuation of aviation diesel spilled on the perennial ice cover of Lake Fryxell, Antarctica. | In January 2003, a helicopter crashed on the 5 m thick perennial ice cover of Lake Fryxell (McMurdo Dry Valleys, East Antarctica), spilling approximately 730 l of aviation diesel fuel (JP5-AN8 mixture). The molecular composition of the initial fuel was analyzed by solid phase microextraction (SPME) gas chromatography-m... | 18,804,261 |
Production of transgenic recloned piglets harboring the human granulocyte-macrophage colony stimulating factor (hGM-CSF) gene from porcine fetal fibroblasts by nuclear transfer. | We used nuclear transfer (NT) to develop transgenic female pigs harboring goat beta-casein promoter/human granulocyte-macrophage colony stimulating factor (hGM-CSF). The expression of hGM-CSF was specific to the mammary gland, and the glycosylation-derived size heterogeneity corresponded to that of the native human pro... | 18,804,273 |
Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1). | Phthalimide neovascular factor (PNF1, formerly SC-3-149) is a potent stimulator of proangiogenic signaling pathways in endothelial cells. In this study, we evaluated the in vivo effects of sustained PNF1 release to promote ingrowth and expansion of microvascular networks surrounding biomaterial implants. The dorsal ski... | 18,804,278 |
Effect of body mass index on shifts in ultrasound-based image-guided intensity-modulated radiation therapy for abdominal malignancies. | We investigated whether corrective shifts determined by daily ultrasound-based image-guidance correlate with body mass index (BMI) of patients treated with image-guided intensity-modulated radiation therapy (IG-IMRT) for abdominal malignancies. The utility of daily image-guidance, particularly for patients with BMI>... | 18,804,301 |
Kinetics of transformation of 1,1,1-trichloroethane by Fe(II) in cement slurries. | This study examines the applicability of the iron-based degradative solidification/stabilization (DS/S-Fe(II)) process to 1,1,1-trichloroethane (1,1,1-TCA), which is one of common chlorinated aliphatic hydrocarbons (CAHs) of concern at contaminated sites. DS/S-Fe(II) combines contaminant degradation by Fe(II) and immob... | 18,804,328 |
Comparison of spine, carina, and tumor as registration landmarks for volumetric image-guided lung radiotherapy. | To assess the feasibility, reproducibility, and accuracy of volumetric lung image guidance using different thoracic landmarks for image registration. In 30 lung patients, four independent observers conducted automated and manual image registrations on Day 1 cone-beam computed tomography data sets using the spine, carin... | 18,804,335 |
Epidemiology of community-acquired pneumonia in older adults: a population-based study. | This study assessed incidence, aetiology, clinical outcomes and risk factors for community-acquired pneumonia (CAP) in older adults. This was a population-based cohort study that included 11,241 community-dwelling individuals aged 65 years or more, who were followed between 2002 and 2005 in the region of Tarragona, Spa... | 18,804,355 |
Unknown primary head and neck cancer treated with intensity-modulated radiation therapy: to what extent the volume should be irradiated. | To evaluate the efficacy and feasibility of irradiation with intensity-modulated radiotherapy (IMRT) technique in patients with head and neck carcinoma of unknown primary (HNCUP). Between February 2000 and November 2006, 22 consecutive patients diagnosed with HNCUP were treated with IMRT. Of these, four patients were e... | 18,804,408 |
The capsaicin receptor participates in artificial sweetener aversion. | Artificial sweeteners such as saccharin, aspartame, acesulfame-K, and cyclamate produce at high concentrations an unpleasant after-taste that is generally attributed to bitter and metallic taste sensations. To identify receptors involved with the complex perception of the above compounds, preference tests were performe... | 18,804,451 |
TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity. | Numerous studies suggest a central role for the low-density lipoprotein receptor-related protein/transforming growth factor beta receptor V in Alzheimer's Disease. We continue our investigation of a ligand for this receptor, transforming growth factor beta2, which is also implicated in Alzheimer Disease pathogenesis, b... | 18,804,458 |
Wnt6 signaling regulates heart muscle development during organogenesis. | Mesodermal tissue with heart forming potential (cardiogenic mesoderm) is induced during gastrulation. This cardiogenic mesoderm later differentiates into heart muscle tissue (myocardium) and non-muscular heart tissue. Inhibition of Wnt/beta-catenin signaling is known to be required early for induction of cardiogenic me... | 18,804,460 |
Brief cross-linking of Fas/APO-1 (CD95) triggers engulfment of pre-apoptotic target cells. | Macrophage clearance of dying cells is of crucial importance to maintain tissue homeostasis. Here, we show that brief treatment (15min) of Jurkat T cells with agonistic anti-Fas antibodies or recombinant Fas ligand results in efficient phagocytosis by human monocyte-derived macrophages prior to the occurrence of common... | 18,804,468 |
Acoustic characteristics, early experience, and endocrine status interact to modulate female zebra finches' behavioral responses to songs. | Female songbirds use male songs as an important criterion for mate selection. Properties of male songs are thought to indicate the male's quality as a potential mate. Song preferences in female zebra finches are known to be influenced by two factors--early auditory experience and the acoustic characteristics of males' ... | 18,804,474 |
Mixed allele malaria vaccines: host protection and within-host selection. | Malaria parasites are frequently polymorphic at the antigenic targets of many candidate vaccines, presumably as a consequence of selection pressure from protective immune responses. Conventional wisdom is therefore that vaccines directed against a single variant could select for non-target variants, rendering the vacci... | 18,804,509 |
The role of amygdala during auditory verbal imagery of derogatory appraisals by others. | We tend to simulate or recall others' appraisals through auditory verbal imagery (AVI) process to react appropriately. In particular, the ability to imagine derogatory appraisals by others may be critically important for social survival. In this study, we investigated the neural correlates implicated in the processing ... | 18,804,514 |
Hoodia gordonii: a natural appetite suppressant. | Several species of the stapeliads, a group of stem succulents belonging to the family Apocynaceae are reported on in the ethnopharmacology literature and many of the references relate to their use as food plants. The most important of these plants is Hoodia gordonii, which during the past decade has risen from an almos... | 18,804,523 |
Molecular signatures associated with transformation and progression to breast cancer in the isogenic MCF10 model. | Comparative microarray analyses provided insight into understanding transcript changes during cancer progression; however, a reproducible signature underlying breast carcinogenesis has yet to be little available. We utilized gene expression profiling to define molecular signatures associated with transformation and can... | 18,804,527 |
Long-term global and regional brain volume changes following severe traumatic brain injury: a longitudinal study with clinical correlates. | Traumatic brain injury (TBI) results in neurodegenerative changes that progress for months, perhaps even years post-injury. However, there is little information on the spatial distribution and the clinical significance of this late atrophy. In 24 patients who had sustained severe TBI we acquired 3D T1-weighted MRIs abo... | 18,804,539 |
Neural substrates of reward magnitude, probability, and risk during a wheel of fortune decision-making task. | Economic decision-making involves the weighting of magnitude and probability of potential gains/losses. While previous work has examined the neural systems involved in decision-making, there is a need to understand how the parameters associated with decision-making (e.g., magnitude of expected reward, probability of ex... | 18,804,540 |
Tissue engineering for bone defect healing: an update on a multi-component approach. | The need for an interdisciplinary approach in order to establish new therapeutic strategies for the therapy of bone defects has been acknowledged by the scientific community for many years. This awareness makes itself felt when looking at the multitude of approaches--ranging from cell-based to scaffold-based strategies... | 18,804,579 |
Improved microfluidic chip-based sequential-injection trapped-droplet array liquid-liquid extraction system for determination of aluminium. | An improved microfluidic chip-based sequential-injection trapped-droplet array liquid-liquid extraction system with chemiluminescence (CL) detection was developed in this work. Two recess arrays were fabricated on both sides of the extraction channel to produce droplet arrays of organic extractant. A chip integrated mo... | 18,804,631 |
Comparison of microwave-assisted digestion procedures for total trace element content determination in calcareous soils. | The aim of the study was to determine total trace (Cd, Co, Cr, Cu, Mn, Pb and Zn) and major (Al and Fe) element concentrations in calcareous soils using microwave-assisted digestion procedures. The literature showing lack of consensus regarding digestion procedures and unsatisfying recoveries for calcareous materials, ... | 18,804,634 |
Renal conservation of folates role of folate transport proteins. | Folates play vital roles in one-carbon metabolism that produces the early substrates necessary for nucleotide synthesis and salvage. Folates are essential vitamins in that humans cannot synthesize them and are totally dependent on the diet to obtain them. As water-soluble vitamins, they would be easily filtered by the ... | 18,804,695 |
Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter. | Folates are essential for life and folate deficiency contributes to a host of health problems including cardiovascular disease, fetal abnormalities, neurological disorders, and cancer. Antifolates, represented by methotrexate, continue to occupy a unique niche among the modern day pharmacopoeia for cancer along with ot... | 18,804,694 |
Statins, low-density lipoprotein cholesterol, and risk of cancer. | We sought to assess whether statin-mediated reductions in low-density lipoprotein cholesterol (LDL-C) are associated with an increased risk of cancer. We recently reported an inverse association between on-treatment LDL-C levels and incident cancer in statin-treated patients enrolled in large randomized controlled tria... | 18,804,740 |
In search of the best method to predict acute coronary syndrome using only the electrocardiogram from the emergency department. | The aim of this study was to compare different methods to predict acute coronary syndrome (ACS) using only data from a single electrocardiogram (ECG) in the emergency department (ED). We compared the ACS prediction abilities of classical ECG criteria, human expert ECG interpretation, a logistic regression model and an ... | 18,804,783 |
Disrupting the interaction between HOX and PBX causes necrotic and apoptotic cell death in the renal cancer lines CaKi-2 and 769-P. | The HOX genes are a family of homeodomain containing transcription factors that determine embryonic tissue identity and also have regulatory and oncogenic roles in adult cells. We quantified the expression of HOX genes in normal kidney tissue, primary tumors and derived cell lines, and examined their role in renal canc... | 18,804,814 |
Contamination by polybrominated diphenyl ethers of sediments from the Lake Maggiore basin (Italy and Switzerland). | Polybrominated diphenyl ethers (PBDEs) are characterized by chemical properties and toxicological profiles similar to other POPs (persistent organic pollutants) included in the EU Priority Pollutant List (2455/01/CE). However, limited data have been available for these compounds thus far for Italian freshwater abiotic ... | 18,804,840 |
Mechanical properties of experimental dental composites containing a combination of mesoporous and nonporous spherical silica as fillers. | Mesoporous fillers have been investigated for use in dental composites because of their potential for creating micromechanical filler/resin matrix interphase bonding. Such a micromechanical bonding could eliminate the need for the silane treatment of fillers for interfacial chemical bonding that is prone to hydrolysis ... | 18,804,855 |
Electrolytic deposition of lithium into calcium phosphate coatings. | Lithium ions stimulate the Wnt signaling pathway and the authors previously demonstrated that lithium enhances the proliferation of tissue cultured human mesenchymal stem cells. The aim of this study was to prepare and characterize a calcium phosphate/lithium coating by means of electrolytic deposition. It was hypothes... | 18,804,857 |
Strontium modified biocements with zero order release kinetics. | Strontium-substituted beta-TCP with the general formula Ca((3-x))Sr(x)(PO(4))(2) (0<x<1) was synthesized by calcination of powder mixtures with the appropriate stoichiometry and reacted with acidic monocalcium phosphate monohydrate (MCPM) to form a cementitious matrix of secondary calcium phosphates. The use of S... | 18,804,862 |
Brominated flame retardants and organochlorines in the European environment using great tit eggs as a biomonitoring tool. | Large-scale studies are essential to assess the emission patterns and spatial distribution of organohalogenated pollutants (OHPs) in the environment. Bird eggs have several advantages compared to other environmental media which have previously been used to map the distribution of OHPs. In this study, large-scale geogra... | 18,804,864 |
Excision repair cross-complementation group 1 (ERCC1) in platinum-based treatment of non-small cell lung cancer with special emphasis on carboplatin: a review of current literature. | Patients diagnosed with advanced non-small cell lung cancer have a dismal prognosis and are often relative resistant to chemotherapy. A need for markers has emerged based on tumour biology in order to predict which patients will respond to treatment. Excision repair cross-complementation group 1 (ERCC1) has shown poten... | 18,804,893 |
Reverse flow flap use in upper extremity burn contractures. | Upper extremity contractures still happen and constitute one of the most trying challenges in burn patients. This series comprised of 4 radial forearm flaps, 14 dorsoulnar artery flaps, and 4 medial arm flaps, all of which were used in a reverse pattern for upper extremity postburn contractures. The reverse flow radial... | 18,804,917 |
Immediate endovascular repair for acute traumatic injuries of the thoracic aorta: a multicenter analysis of 28 cases. | Endovascular repair of injured thoracic aorta offers a new minimal invasive therapeutic option that could be beneficial in the urgent management of polytrauma patients. The aim of this study was to assess our multicenter experience of immediate endovascular repair for acute traumatic injuries of the thoracic aorta. Bet... | 18,804,937 |
Concurrent splenic peliosis and vascular Ehlers-Danlos syndrome. | This case report describes concurrent splenic peliosis and vascular Ehlers-Danlos syndrome (EDS) in a 59-year-old male patient. After splenic rupture due to peliosis, the complicated postoperative period hinted at the possibility of vascular EDS. This diagnosis was confirmed by genetic testing, which revealed a novel p... | 18,804,950 |
Leiomyoma of the greater saphenous vein: a case report and review of the literature. | Greater saphenous vein tumors are exceedingly rare, whether benign or malignant. Leiomyoma is one of the benign vascular tumors that can present as a localized mass; however, the diagnosis cannot be made clinically. Multiple radiologic imagings are usually required, as well as histological examination, to make a defini... | 18,804,951 |
Changes in glucose metabolism due to aging and gender-related differences in the healthy human brain. | Using [(18)F]fluoro-deoxy-glucose-PET, we studied relative metabolic changes due to age- and gender-related differences in the brain of 126 healthy subjects from their twenties to seventies. We used a data-extraction technique, the three-dimensional stereotactic surface projections (3D-SSP) method, to measure metabolic... | 18,804,967 |
Association of genetic profiles to Crohn's disease by linear combinations of single nucleotide polymorphisms. | A large number of single nucleotide polymorphisms (SNPs) are supposed to be involved in onset, differentiation and development of complex diseases. Univariate analysis is limited in studying complex traits since does not take into account gene-gene interaction, and the correlation of multiple SNPs with a specific pheno... | 18,804,983 |
Altered monocyte CD44 expression in peripheral arterial disease is corrected by fish oil supplementation. | CD44 and its splice variants can be expressed on all leukocytes, conferring adhesive properties and enhancing cellular recruitment to the endothelium during inflammation. CD44 expression is increased in inflammatory conditions such as rheumatoid arthritis and CD44 variant 3 (CD44v3) expression may be associated with in... | 18,804,988 |
A new amperometric nanostructured sensor for the analytical determination of hydrogen peroxide. | A new amperometric, nanostructured sensor for the analytical determination of hydrogen peroxide is proposed. This sensor was constructed by immobilizing silver nanoparticles in a polyvinyl alcohol (PVA) film on a platinum electrode, which was performed by direct drop-casting silver nanoparticles that were capped in a P... | 18,804,993 |
Do earthworms affect dynamics of functional response and genetic structure of microbial community in a lab-scale composting system? | Two laboratory-scale systems were set up (i) composting (without earthworms) and (ii) vermicomposting (with earthworms) and were monitored for 60 days after pre-composting. The physico-chemical parameters (pH, C/N, organic matter, NH(4)(+)-N and ash content) showed similar evolution in both systems except a higher NH(4... | 18,805,002 |
Fluorescent polycyclic ligands for nitric oxide synthase (NOS) inhibition. | In recent years polycyclic compounds have been shown to exhibit pharmacological profiles of importance in the symptomatic and proposed curative treatment of neurodegenerative diseases (e.g., Parkinson's and Alzheimer's disease). These structures also show modification and improvement of the pharmacokinetic and pharmaco... | 18,805,011 |
Biomechanical analysis of axial distraction mobilization of the glenohumeral joint--a cadaver study. | The axial distraction mobilization techniques are frequently employed for treating patients with joint hypomobility. However, there is a lack of basic biomechanical studies and description of this procedure. The purpose of this study was to analyze humeral head displacement while performing an axial distraction mobiliz... | 18,805,038 |
Expression of growth differentiation factor 15 is positively correlated with histopathological malignant grade and in vitro cell proliferation in oral squamous cell carcinoma. | Previously, we established an in vitro cellular carcinogenesis model of oral squamous cell carcinoma (OSCC) and expression microarray analysis showed that the gene encoding growth differentiation factor 15 (GDF15) was significantly upregulated in this model. In this study, we confirmed that expression of GDF15 was incr... | 18,805,046 |
A SEC-HPLC-ICP MS hyphenated technique for identification of sulfur-containing arsenic metabolites in biological samples. | The present study describes the synthesis and characterization of thioarsenicals using electro-spray ionization-MS and time of flight-MS. Separation of thioarsenicals was found to be better by size-exclusion column compared to anion exchange column coupled with HPLC-inductively coupled argon plasma mass spectrometer (I... | 18,805,071 |
Lasker-Koshland Award to 21st century microbe master. | The 2008 Lasker-Koshland Award will be presented to Stanley Falkow, one of the legendary figures in the history of microbiology research. Falkow's many contributions remade the way we think about bacterial pathogens, antibiotic resistance, and infectious disease. | 18,805,081 |
Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. | The different cell types in the central nervous system develop from a common pool of progenitor cells. The nuclei of progenitors move between the apical and basal surfaces of the neuroepithelium in phase with their cell cycle, a process termed interkinetic nuclear migration (INM). In the retina of zebrafish mikre oko (... | 18,805,097 |
Comparative outcome of bidirectional Glenn shunt in patients with pulmonary vascular resistance > or = 3.5 woods units versus < 3.5 woods units. | Moderate to severe pulmonary hypertension is considered to be an absolute contraindication to the performance of bidirectional Glenn (BDG) shunting. However, BDG shunting has been performed in young children with pulmonary hypertension associated with unrestricted pulmonary blood flow. In this study, the medical record... | 18,805,120 |
Defining optimal research study design for cardiovascular imaging using computed tomography angiography as a model. | Patients, physicians, and payers are facing a significant increase in cardiovascular (CV) imaging use, resulting in skyrocketing societal costs, without clear improvement in patient outcomes. The need for studies evaluating the effects of CV imaging that assess appropriate end points is critical to address continued co... | 18,805,127 |
Endobronchial ultrasound-guided fine-needle aspiration of mediastinal lymph nodes: a single institution's early learning curve. | The gold standard for mediastinal lymph node evaluation is mediastinoscopy, which is invasive and allows access to only a limited number of mediastinal lymph node (MLN) stations (1, 2, 3, 4, and 7). Endobronchial ultrasound-guided fine-needle aspiration (EBUS-FNA) is emerging as a useful, less invasive technique that o... | 18,805,141 |
Clinical application of direct bronchial ultrasound to visualize and determine endobronchial tumor margins for surgical resection. | We describe the first experience of direct bronchial (epi-bronchial) ultrasound to visualize and determine the endobronchial tumor margins for surgical resection. An ultrasound probe was applied onto the membranous portion of the right main bronchus directly over a pedunculated tumor. The tumor was visualized due to th... | 18,805,189 |
Veno-venous extracorporeal membrane oxygenation in surgery for bronchial repair. | Single-lung ventilation using a double-lumen endobronchial tube is often performed for surgical procedures involving the thorax. Tracheobronchial rupture during use of an endobronchial tube is an uncommon and serious complication. We present the case of a patient undergoing a right pneumonectomy who experienced a bronc... | 18,805,192 |
Early aortic bioprosthetic valve deterioration in an octogenarian. | We experienced extremely early aortic bioprosthetic valve deterioration with leaflet calcification and stiffening 2 1/2 years after aortic valve replacement in a female octogenarian. We could not identify the possible reason for this devastating complication; however, daily calcium supplement consumption may play a rol... | 18,805,202 |
Cone beam tomographic imaging anatomy of the maxillofacial region. | Multiplanar imaging is a fairly new concept in diagnostic imaging available with a number of contemporary imaging modalities such as CT, MR imaging, diagnostic ultrasound, and others. This modality allows reconstruction of images in different planes (flat or curved) from a volume of data that was acquired previously. T... | 18,805,226 |
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