title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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The base rate of effort test failure in patients with medically unexplained symptoms. | "Effort tests" (i.e., tests that indicate whether appropriate effort is being made) are increasingly used in neuropsychological assessments. However, not all failures on effort tests are necessarily attributable to lack of effort. Understanding the factors that contribute to failure on effort tests has important clinic... | 18,805,240 |
Mitral valve motion after performing an edge-to-edge repair in an isolated swine heart. | Mitral valve motion after performing an edge-to-edge repair is a major concern, but it has not yet been observed directly. Mitral valve motion was assessed by using a high-speed digital video camera and microsonometric analysis in an isolated swine heart, and any changes in the mitral valve area or the development of m... | 18,805,256 |
New targets for drug development in asthma. | Asthma is a chronic inflammatory disease that affects about 300 million people worldwide, a total that is expected to rise to about 400 million over the next 15-20 years. Most asthmatic individuals respond well to the currently available treatments of inhaled corticosteroids and beta-adrenergic agonists; however, 5-10%... | 18,805,336 |
Pontocerebellar hypoplasia type 1. | Pontocerebellar hypoplasias are heterogeneous disorders that share a reduction in the size of brainstem and cerebellum. We describe a patient with features of the rare combination of pontocerebellar hypoplasia and spinal motor neuron disease. Parental consanguinity, low Apgar scores, facial weakness, dysphagia, tongue ... | 18,805,371 |
A simple assay for hyaluronidase activity using fluorescence polarization. | Hyaluronan is a large glycosaminoglycan and is a major constituent of the extracellular matrix, interacting with cell surface receptors such as CD44. We previously reported that fragmented hyaluronan, with the size frequently detected in cancer patients, induces CD44 cleavage and concomitantly enhances tumor cell migra... | 18,805,398 |
The promiscuity of ARF interactions with the proteasome. | The tumor suppressor ARF is one of the most important oncogenic stress sensors in mammalian cells. Its effect is exerted through the interaction with different cellular partners, often resulting in their functional inactivation. This review focuses on the role played by the proteasome in ARF regulation of protein turno... | 18,805,416 |
Marked differences between atrial and ventricular gene-expression remodeling in dogs with experimental heart failure. | Congestive heart failure (CHF) causes arrhythmogenic, structural and contractile remodeling, with important atrial-ventricular differences: atria show faster and greater inflammation, cell-death and fibrosis. The present study assessed time-dependent left atrial (LA) and ventricular (LV) gene-expression changes in CHF.... | 18,805,423 |
Molecular cloning, tissue distribution and expression profiles of thyroid hormone receptors during embryogenesis in orange-spotted grouper (Epinephelus coioides). | Three distinct thyroid hormone receptor (TR) cDNAs (gTRalphaA, gTRalphaB and gTRbeta) were cloned and sequenced in orange-spotted grouper (Epinephelus coioides). The cDNA of gTRalphaA consisted of 1555-bp and encoded a putative protein of 416 amino acids, while the cDNA of gTRalphaB consisted of 1459-bp and encoded 398... | 18,805,420 |
Single-molecule fluorescence resonance energy transfer assays reveal heterogeneous folding ensembles in a simple RNA stem-loop. | We have examined the folding ensembles present in solution for a series of RNA oligonucleotides that encompass the replicase translational operator stem-loop of the RNA bacteriophage MS2. Single-molecule (SM) fluorescence assays suggest that these RNAs exist in solution as ensembles of differentially base-paired/base-s... | 18,805,425 |
Interplay between lipids and the proteinaceous membrane fusion machinery. | For membrane fusion to occur, opposed lipid bilayers initially establish a fusion pore, often followed by complete mixing of the fusing membranes. Contemporary views suggest that during fusion lipid bilayers are continuous passive platforms that are disrupted and remodeled by catalytic proteins. Some models propose tha... | 18,805,437 |
A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus. | Severe acute respiratory syndrome (SARS) is a serious infectious disease caused by the SARS coronavirus. We assessed the potential of prime-boost vaccination protocols based on the nucleocapsid (NC) protein co-administered with a derivative of the mucosal adjuvant MALP-2 or expressed by modified Vaccinia virus Ankara (... | 18,805,454 |
Immediate release pellets with lipid binders obtained by solvent-free cold extrusion. | Lipid-based drug delivery systems have spread in their use in pharmaceutical drug development. This work focuses on the use of lipid binders as alternative non-toxic extrusion aid for pellet formulations. The preparation of immediate release pellets with solid lipid binders through a solvent-free cold extrusion/spheron... | 18,805,483 |
Vasoprotective endothelial effects of a standardized grape product in humans. | The pathogenesis of coronary lesion development is a multi-factorial process involving a number of different cell types and covariates, and injury and dysfunction of the vascular endothelium is an important marker and likely participant in the initiation and/or progression of most forms of heart disease. In addition to... | 18,805,507 |
Introducing N-glycans into natural products through a chemoenzymatic approach. | The present study describes an efficient chemoenzymatic method for introducing a core N-glycan of glycoprotein origin into various lipophilic natural products. It was found that the endo-beta-N-acetylglucosaminidase from Arthrobactor protophormiae (Endo-A) had broad substrate specificity and can accommodate a wide rang... | 18,805,520 |
Effect of LIMK2 RNAi on reorganization of the actin cytoskeleton in osteoblasts induced by fluid shear stress. | The biomechanical characteristics of bone tissue and its cells under mechanical stress are significant for bone biomechanics research, but the mechanism of mechanotransduction is still unknown. It has been established that the actin cytoskeleton of osteoblasts plays an important role in this process. However, the struc... | 18,805,530 |
Assessment of in vivo and post-mortem mechanical behavior of brain tissue using magnetic resonance elastography. | The knowledge of in vivo brain tissue mechanical properties is essential in several biomedical engineering fields, such as injury biomechanics and neurosurgery simulation. Almost all existing available data have been obtained in vitro by invasive experimental protocols. However, the difference between in vivo and post-... | 18,805,534 |
Autoimmune-mediated oxidative stress and endothelial dysfunction: implications of accelerated vascular injury in type I diabetes. | The pathogenesis of cardiovascular disease in the setting of type 1 diabetes is not well-defined. The hypothesis that hyperglycemia is largely responsible for vascular endothelial dysfunction, and ultimately atherosclerosis, continues to evolve. However, despite tight glucose control, a subset of patients still develop... | 18,805,553 |
Mechanism of injury predicts patient mortality and impairment after blunt trauma. | Different mechanisms of injury (MOI), such as motor vehicle crashes, falls, or pedestrians struck by motor vehicle impart varying degrees of force and energy transfer that may impact outcomes. This study analyzed the independent relationship between MOI and mortality and functional outcomes following blunt trauma among... | 18,805,554 |
Is meltwater from Alpine glaciers a secondary DDT source for lakes? | A sharp increase in 2005 of pp'DDT and its metabolites was observed in mussels and fish from lakes Como and Iseo, the main glacier-fed southern Alpine lakes. DDTs in zebra mussels (Dreissena polymorpha) were more than 150 times higher than levels in 2003, and concentrations in pelagic fish (0.12 mgkg(-1) w.w.) exceeded... | 18,805,565 |
Effects of long-term soil amendment with sewage sludges on soil humic acid thermal and molecular properties. | Sewage sludges are frequently used as soil amendments due to their high contents of organic matter and nutrients, particularly N and P. However, their effects upon the chemistry of soil humic acids, one of the main components of the soil organic matter, need to be more deeply studied in order to understand the relation... | 18,805,567 |
Short- and medium-term effects of fire and fire-fighting chemicals on soil micronutrient availability. | The impact of fire and three fire-fighting chemicals (FFC) on soil micronutrient availability was evaluated 1, 90 and 365 days after a prescribed fire. Five treatments were considered: unburnt soil (US) and burnt soil with 2 l m(-2) of water (BS) or water with foaming agent Auxquímica RFC-88 at 1% (BS+Fo), Firesorb at ... | 18,805,571 |
Robotic-assisted laparoscopic approach for posterior bladder neck dissection and placement of pediatric bladder neck sling: initial experience. | Bladder neck sling cystourethropexy is a common procedure used to correct intrinsic sphincter deficiency in children with spinal dyspharism. Various modifications of the procedure have been made but all involve circumferential dissection of the bladder neck and proximal urethra. The posterior dissection can be challeng... | 18,805,574 |
Synchronous occult cancers of the endometrium and fallopian tube in an MSH2 mutation carrier at time of prophylactic surgery. | Women with Lynch syndrome have a 40 to 60% lifetime risk of endometrial cancer and a 10 to 12% lifetime risk of ovarian cancer and may consider prophylactic gynecological surgery as an option for risk reduction. We report a case of synchronous primary cancers of the endometrium and fallopian tube diagnosed at time of p... | 18,805,575 |
Maternal and fetal C-reactive protein genotype and first trimester CRP concentrations in maternal plasma. | Maternal plasma CRP concentrations in pregnancy are increased over pre-pregnancy values and high concentrations have been associated with adverse obstetrical outcomes. The objective of this study was to explore the relationship between maternal and fetal variation in C-reactive protein (CRP) genotype and maternal plasm... | 18,805,592 |
Cardiovascular risk and memory in non-demented elderly women. | To determine whether cardiovascular (CV) risk is associated with subtle memory deficits in non-demented, healthy older women with a family history of Alzheimer disease (AD). Baseline data of 375 participants from a randomized, double-blind placebo-controlled primary prevention trial to test the efficacy of hormone repl... | 18,805,604 |
Acquired Gitelman syndrome in a patient with primary Sjögren syndrome. | Acquired Gitelman syndrome (GS) associated with Sjögren syndrome (SS) is rare, and the test to determine the pathophysiological state of acquired GS in patients with primary SS has not been reported previously. A 47-year-old woman with sicca complex presented to our clinic with intermittent muscle cramping and weakness... | 18,805,608 |
Caspase inhibitor zVAD.fmk reduces infarct size after myocardial ischaemia and reperfusion in rats but not in mice. | Apoptosis of cardiomyocytes has been suggested to contribute to outcome following myocardial ischaemia and reperfusion (MI/R). Caspase inhibitors were developed as potential therapeutics for MI/R. However, various reports using the broad-spectrum caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (zVA... | 18,805,622 |
Toxic waste in our midst: towards an interdisciplinary analysis. | Intractable industrial legacies present new challenges to governance. Amongst the persistent organic pollutants, now managed internationally under the Stockholm Convention, hexachlorobenzene (HCB) stands out in all three classes of chemicals (pesticides, industrial chemicals and unintended by-products). This paper intr... | 18,805,624 |
Nitrate removal from electro-oxidized landfill leachate by ion exchange. | Treatment of landfill leachates by electrochemical oxidation led to the complete removal of chemical oxygen demand and ammonium nitrogen. However, as result of the ammonium oxidation, the partial formation of nitrate ions was observed. Ion exchange technology was investigated as a polishing step in the treatment of lan... | 18,805,640 |
Incidence and determinants of initiation into cocaine injection and correlates of frequent cocaine injectors. | To investigate the incidence and correlates of cocaine injection initiation and the impacts of daily cocaine injection among a cohort of injection drug users. Among 1603 participants, from May 1996 to December 2005, risk factors for initiation of cocaine injection among baseline heroin users were determined by Cox prop... | 18,805,655 |
Predictors of outcome for short-term medically supervised opioid withdrawal during a randomized, multicenter trial of buprenorphine-naloxone and clonidine in the NIDA clinical trials network drug and alcohol dependence. | Few studies in community settings have evaluated predictors, mediators, and moderators of treatment success for medically supervised opioid withdrawal treatment. This report presents new findings about these factors from a study of 344 opioid-dependent men and women prospectively randomized to either buprenorphine-nalo... | 18,805,656 |
Measurement of the intrarenal arterial resistance index for the identification and prediction of diabetic nephropathy. | High intrarenal resistance index (RI) predicts renal function in several conditions; its use in the prediction of diabetic nephropathy (DN) is little explored. We aimed (1) to compare RI in diabetic and non diabetic hypertensive patients, and (2) to evaluate whether high RI is associated with clinical signs of DN and i... | 18,805,683 |
Why don't out-of-treatment individuals enter methadone treatment programmes? | Despite the proven effectiveness of methadone treatment, the majority of heroin-dependent individuals are out-of-treatment. Twenty-six opioid-dependent adults who met the criteria for methadone maintenance who were neither seeking methadone treatment at the time of study enrollment, nor had participated in such treatme... | 18,805,686 |
Spectroscopic and theoretical study of 2-acetylphenyl-2-naphthoate. | Mid-, far-infrared and Raman vibrational spectra of 2-acetylphenyl-2-naphthoate have been measured at room and low temperatures. The molecule was also analyzed by means of ab initio calculations. The conformational space has been scanned using molecular dynamics and complemented with functional density calculations tha... | 18,805,730 |
[Some recent ethical dilemmas in randomized controlled clinical trials]. | Randomized controlled clinical trials (RCTs) are the golden standard of contemporary medical research. Just because they are ever more widespread, they stand at the focus of intense ethical debate. The debates have focused on the questions, how much the research participants can benefit from the research, and even if t... | 18,805,759 |
[Clinical application of nanoparticles, and their possible health risk]. | Nanomaterials are getting rapidly developing practical applications, beside many others also in the clinical practice. Their beneficial attributes make the use of the nanostructures a large improvement in effective therapy as coating of implants, bone replacement materials, coating of active substances, nano-sized lipo... | 18,805,764 |
Human T-cell leukemia virus type 1 HBZ protein bypasses the targeting function of ubiquitination. | Human T-cell leukemia virus type 1 (HTLV-1) encodes an antisense viral gene product termed HTLV-1 basic leucine-zipper factor (HBZ). HBZ forms heterodimers with c-Jun, a member of the AP-1 family, and promotes its proteasomal degradation. Although most proteasomal substrates are targeted for degradation via conjugation... | 18,805,793 |
Cellular mechanisms of Cnidarian bleaching: stress causes the collapse of symbiosis. | Cnidarian bleaching is a breakdown in the mutualistic symbiosis between host Cnidarians, such as reef building corals, and their unicellular photosynthetic dinoflagellate symbionts. Bleaching is caused by a variety of environmental stressors, most notably elevated temperatures associated with global climate change in c... | 18,805,804 |
Effects of [Ca2+]i and pH on epithelial Na+ channel activity of cultured mouse cortical collecting ducts. | [Ca2+]i and pH have been demonstrated to affect Na+ transport in epithelium mediated via the apical epithelial Na+ channel (ENaC). However, it still remains unclear whether the effects of [Ca2+]i and intracellular pH (pHi) on ENaC activity are direct. In this study, inside-out recording was employed to clarify the effe... | 18,805,816 |
Investigating the variations in survival rates for very preterm infants in 10 European regions: the MOSAIC birth cohort. | To investigate the variation in the survival rate and the mortality rates for very preterm infants across Europe. A prospective birth cohort of very preterm infants for 10 geographically defined European regions during 2003, followed to discharge home from hospital. All deliveries from 22 + 0 to 31 + 6 weeks' gestation... | 18,805,823 |
Diagnostic evaluation of people with hypertension in low income country: cohort study of "essential" method of risk stratification. | To explore the predictive power of a risk stratification method for people with hypertension based on "essential" procedures (that is, available in economically less developed areas of the world), comparing it in the same population with the results given by the method suggested by the 1999 World Health Organization-In... | 18,805,835 |
Early highly aggressive MS successfully treated by hematopoietic stem cell transplantation. | During the last 15 years, high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HSCT) has globally been performed for severe multiple sclerosis (MS). Most patients have been in progressive phase with long disease duration. As a rule, treatment effect has been minor or moderate. Since 2004, we ... | 18,805,841 |
Rigid spin-labeled nucleoside C: a nonperturbing EPR probe of nucleic acid conformation. | Rigid spin-labeled nucleoside C, an analog of deoxycytidine that base-pairs with deoxyguanosine, was incorporated into DNA oligomers by chemical synthesis. Thermal denaturation experiments and circular dichroism (CD) measurements showed that C has a negligible effect on DNA duplex stability and conformation. Nucleoside... | 18,805,908 |
Gender dimorphism in body composition abnormalities in acromegaly: males are more affected than females. | Acromegaly changes body composition (BC), but long-term gender differences have not been reported. To evaluate BC in active and controlled acromegalic patients. Clinical and biochemical variables and BC (by dual-energy X-ray absorptiometry) were evaluated in 60 acromegalic patients (19 active, 41 controlled) and 105 co... | 18,805,912 |
The Gaussian curvature elastic energy of intermediates in membrane fusion. | The Gaussian curvature elastic energy contribution to the energy of membrane fusion intermediates has usually been neglected because the Gaussian curvature elastic modulus, kappa, was unknown. It is now possible to measure kappa for phospholipids that form bicontinuous inverted cubic (Q(II)) phases. Here, it is shown t... | 18,805,927 |
Atypical object exploration at 12 months of age is associated with autism in a prospective sample. | This prospective study examined object exploration behavior in 66 12-month-old infants, of whom nine were subsequently diagnosed with an autism spectrum disorder. Previous investigations differ on when the repetitive behaviors characteristic of autism are first present in early development. A task was developed that af... | 18,805,942 |
Distinct roles for Khd1p in the localization and expression of bud-localized mRNAs in yeast. | The RNA-binding protein Khd1p (KH-domain protein 1) is required for efficient localization of ASH1 mRNA to the bud-tip, probably acting as a translational repressor during mRNA transport in yeast. Here, we have systematically examined Khd1p mRNA targets and colocalization with known bud-tip-localized mRNAs in vivo. Aff... | 18,805,955 |
Effects of distension on airway inflammation and venular P-selectin expression. | We previously have shown in mice and rats, enhanced leukocyte recruitment to airway postcapillary venules after excessive distention imposed by the application of positive end-expiratory pressure. Because P-selectin was shown to be essential for this outcome, we sought to establish an in vitro endothelial cell model an... | 18,805,956 |
Pharmacokinetics, pharmacodynamics, efficacy, and safety of a new recombinant asparaginase preparation in children with previously untreated acute lymphoblastic leukemia: a randomized phase 2 clinical trial. | The pharmacokinetics, pharmacodynamics, efficacy, and safety of a new recombinant Escherichia coli-asparaginase preparation was compared with Asparaginase medac. Thirty-two children with acute lymphoblastic leukemia were randomized to receive one of both agents at a dose of 5000 U/m(2) every 3 days, for a total of 8 do... | 18,805,963 |
Posttranslational modification influences the effects of MgrA on norA expression in Staphylococcus aureus. | MgrA is a global regulator in Staphylococcus aureus. Differences in the effects of MgrA on norA expression have been reported for different strains, which varied in rsbU, a gene that affects the expression of sigB, which encodes an alternative sigma factor involved in stress responses. We hypothesized that MgrA was mod... | 18,805,983 |
Transcriptional regulation of the citrate gene cluster of Enterococcus faecalis Involves the GntR family transcriptional activator CitO. | The genome of the gram-positive bacterium Enterococcus faecalis contains the genes that encode the citrate lyase complex. This complex splits citrate into oxaloacetate and acetate and is involved in all the known anaerobic bacterial citrate fermentation pathways. Although citrate fermentation in E. faecalis has been in... | 18,805,984 |
TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. | The Trp53 gene family member Trp73 encodes two major groups of protein isoforms, TAp73 and DeltaNp73, with opposing pro- and anti-apoptotic functions; consequently, their relative ratio regulates cell fate. However, the precise roles of p73 isoforms in cellular events such as tumor initiation, embryonic development, an... | 18,805,989 |
A protracted and dynamic maturation schedule underlies Arabidopsis leaf development. | Leaf development has been monitored chiefly by following anatomical markers. Analysis of transcriptome dynamics during leaf maturation revealed multiple expression patterns that rise or fall with age or that display age-specific peaks. These were used to formulate a digital differentiation index (DDI) based on a set of... | 18,805,992 |
Identification of Campylobacter jejuni proteins recognized by maternal antibodies of chickens. | Campylobacter jejuni is one of the leading bacterial causes of food-borne gastroenteritis. Infection with C. jejuni is frequently acquired through the consumption of undercooked poultry or foods cross-contaminated with raw poultry. Given the importance of poultry as a reservoir for Campylobacter organisms, investigator... | 18,805,999 |
The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients. | Acute hypertension during cardiac surgery can be difficult to manage and may adversely affect patient outcomes. Clevidipine is a novel, rapidly acting dihydropyridine L-type calcium channel blocker with an ultrashort half-life that decreases arterial blood pressure (BP). The Evaluation of CLevidipine In the Perioperati... | 18,806,012 |
Pharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 years. | Caudal administration of levobupivacaine (2.5 mg/kg) in children is used frequently in some hospitals. However, no reports of levobupivacaine concentrations have been published with this dosing scheme. We report the results of a study on the pharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in... | 18,806,025 |
The accuracy and clinical feasibility of a new bayesian-based closed-loop control system for propofol administration using the bispectral index as a controlled variable. | Closed-loop control of the hypnotic component of anesthesia has been proposed in an attempt to optimize drug delivery. Here, we introduce a newly developed Bayesian-based, patient-individualized, model-based, adaptive control method for bispectral index (BIS) guided propofol infusion into clinical practice and compare ... | 18,806,028 |
The risk of pulmonary aspiration in patients after weight loss due to bariatric surgery. | We conducted a study including patients with gastric banding or gastroplasty who previously underwent plastic or functional surgery to assess the risk of pulmonary aspiration. A retrospective case-control study was performed including all patients undergoing a plastic or functional surgery over a 5-yr period (2000-2005... | 18,806,037 |
Perioperative management of patients with an intrathecal drug delivery system for chronic pain. | The use of intrathecal medications in the treatment of chronic pain is becoming more commonplace. As such, the incidence of encountering patients receiving therapy via an intrathecal drug delivery system in the perioperative period will also increase. In this case series, we discuss anesthetic management and postoperat... | 18,806,058 |
The effect of injectate conductivity on the electric field with the nerve stimulator needle: a computer simulation. | Electrical neural stimulation is commonly used to localize neural structures and place local anesthetic for regional anesthesia. The sharp tip of the stimulating needle gives rise to an electric field which is highly localized. The electrostatic effect of the injected solution on the field distribution and strength has... | 18,806,064 |
Urethral injury during potassium-titanyl-phosphate laser prostatectomy complicated by transurethral resection syndrome. | The green light potassium-titanyl-phosphate laser photoselective vaporization of the prostate is the latest modality for treatment of benign prostatic obstruction. Because of effective superficial tissue coagulation, intravascular absorption of fluid is minimal; therefore, development of transurethral resection syndrom... | 18,806,066 |
Statins and sepsis: good bullet, disappearing target. | Despite several decades of research and phenomenal advances in technology and therapeutics, sepsis remains a catastrophic enigma. As a frequent cause of death, sepsis now rivals acute myocardial infarction. The longstanding therapeutic principles of early antibiotics use and supportive care have been difficult to impro... | 18,806,077 |
Postpartum thyroid measures and depressive symptomology: a pilot study. | While correlations have been demonstrated between postpartum depression and psychosocial and circumstantial risk factors, some evidence exists for a similar relationship between postpartum depression and thyroid measures. To search at 4 weeks postpartum for correlations of numerical scores on a postnatal depression scr... | 18,806,079 |
Incidental pleural-based pulmonary lymphangioma. | Adult benign thoracic lymphangiomas typically present as incidental mediastinal lesions, or, more rarely, as solitary pulmonary nodules. Symptomatic compression of vital structures may require lesion resection or sclerotherapy. In the present report, we describe the incidental finding of a solitary pleural-based pulmon... | 18,806,082 |
Clinical use of glutamine supplementation. | Endogenous production of glutamine may become insufficient during critical illness. The shortage of glutamine is reflected as a decrease in plasma concentration, which is a prognostic factor for poor outcome in sepsis. Because glutamine is a precursor for nucleotide synthesis, rapidly dividing cells are most likely to ... | 18,806,121 |
Radiodefluorination of 3-fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a radioligand for imaging brain metabotropic glutamate subtype-5 receptors with positron emission tomography, occurs by glutathionylation in rat brain. | Metabotropic glutamate subtype-5 receptors (mGluR5) are implicated in several neuropsychiatric disorders. Positron emission tomography (PET) with a suitable radioligand may enable monitoring of regional brain mGluR5 density before and during treatments. We have developed a new radioligand, 3-fluoro-5-(2-(2-[(18)F](fluo... | 18,806,125 |
MRI appearance of posterior cruciate ligament tears. | There is little in the radiology literature regarding the MRI appearance of a torn posterior cruciate ligament (PCL). The purpose of this study was to describe the MRI appearance of surgically proven PCL tears and to emphasize previously unreported signs. The PCL is usually injured as the result of stretching deformati... | 18,806,138 |
Feasibility of MRI of the fetal heart with balanced steady-state free precession sequence along fetal body and cardiac planes. | The purpose of this study was to evaluate the feasibility of imaging the fetal heart with a balanced steady-state free precession MRI sequence along the body and cardiac axes after inadequate echocardiography. After technically inadequate echocardiography, MRI was performed on 20 fetuses (mean gestational age, 24 weeks... | 18,806,167 |
Comparison of contrast-enhanced sonography with unenhanced sonography and contrast-enhanced CT in the diagnosis of malignancy in complex cystic renal masses. | The objective of our study was to evaluate contrast-enhanced sonography in the diagnosis of malignancy in complex cystic renal masses. We analyzed a series of 40 cystic renal masses (diameter, 2-8 cm) with a complex pattern at contrast-enhanced CT in 40 consecutive subjects (18 men, 22 women; mean age +/- SD, 62 +/- 11... | 18,806,171 |
'They're more like ordinary stroppy British women': attitudes and expectations of maternity care professionals to UK-born ethnic minority women. | To explore the attitudes and expectations of maternity care professionals to UK-born ethnic minority mothers. Qualitative in-depth interviews with 30 professionals from eight NHS maternity units in England that provide services for large proportions of women of black Caribbean, black African, Indian, Pakistani and Iris... | 18,806,176 |
Factors contributing to nursing leadership: a systematic review. | Leadership practices of health care managers can positively or negatively influence outcomes for organizations, providers and, ultimately, patients. Understanding the factors that contribute to nursing leadership is fundamental to ensuring a future supply of nursing leaders who can positively influence outcomes for hea... | 18,806,183 |
What leads to better health care innovation? Arguments for an integrated policy-oriented research agenda. | This essay is based on the recognition that the current 'downstream' health services research and policy approach to innovation misses the mark on one crucial point. It has not addressed how to promote the design of innovations that are likely to be more valuable than others. Re-visiting the ways in which health servic... | 18,806,185 |
MOBILE and the provision of total joint replacement. | Modern joint replacements have been available for 45 years, but we still do not have clear indications for these interventions, and we do not know how to optimize the outcome for patients who agree to have them done. The MOBILE programme has been investigating these issues in relation to primary total hip and knee join... | 18,806,192 |
Endovenous laser ablation: mechanism of action. | The objective of this study is to review the basics of laser and established tissue response patterns to thermal injury, with specific reference to endovenous laser ablation (EVLA). This study also reviews the current theories and supporting aspects for the mechanism of action of EVLA in the treatment of superficial ve... | 18,806,202 |
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. | A recessive phenotype called spin (spontaneous inflammation) was induced by N-ethyl-N-nitrosourea (ENU) mutagenesis in C57BL/6J mice. Homozygotes display chronic inflammatory lesions affecting the feet, salivary glands and lungs, and antichromatin antibodies. They are immunocompetent and show enhanced resistance to inf... | 18,806,225 |
Disrupted development of the dominant hemisphere following prenatal irradiation. | One hundred children, exposed prenatally to radiation after the Chernobyl nuclear power plant accident, and 50 nonexposed classmates were examined between the ages of 11 and 13 years old using neuropsychiatric tests, WISC, EEG, and visual evoked potentials. Individual prenatal radiation doses were reconstructed for all... | 18,806,231 |
Multiple protein domains mediate interaction between Bcl10 and MALT1. | Bcl10 and MALT1 are essential mediators of NF-kappaB activation in response to the triggering of a diverse array of transmembrane receptors, including antigen receptors. Additionally, both proteins are translocation targets in MALT lymphoma. Thus, a detailed understanding of the interaction between these mediators is o... | 18,806,265 |
Circulating hematopoietic stem cells in patients with idiopathic choroidal neovascularization. | In a prior study, the correlation was investigated between circulating hematopoietic stem cells (HSCs) and the activity or severity of choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD). The present study was designed to explore the role of circulating HSCs in the pathogenesis of... | 18,806,291 |
Suppression of influenza A virus nuclear antigen production and neuraminidase activity by a nutrient mixture containing ascorbic acid, green tea extract and amino acids. | Influenza, one of the oldest and most common infections, poses a serious health problem causing significant morbidity and mortality, and imposing substantial economic costs. The efficacy of current drugs is limited and improved therapies are needed. A unique nutrient mixture (NM), containing ascorbic acid, green tea ex... | 18,806,304 |
Oxidation of glutathione and superoxide generation by inorganic and organic selenium compounds. | The carcinostatic activities of selenium (Se) compounds have been shown to be composition and concentration dependent. Several studies have indicated that the ratios between glutathione (GSH) and Se may play an important role in Se catalysis and toxicity. The present study examined the catalytic effect of three seleniu... | 18,806,309 |
Attenuation of mitochondrial injury by L-arginine preconditioning of the liver. | The present study was aimed to evaluate the efficacy of L-arginine on mitochondrial function in ischemic and reperfusion (I/R) induced hepatic injury. Adult Wistar rat were subjected to 1 h of partial liver ischemia followed by 3 hour reperfusion. Eighteen wistar rats were divided into three groups viz. sham-operated c... | 18,806,313 |
Serum selenium concentration in healthy children living in Tehran. | Selenium is one of the essential trace elements which is more notified in children in recent years. Reliable age-specific reference values for selenium in children in Iran are not clear and are important for the identification of selenium deficiency and some other researches that is the aim of this study. Serum samples... | 18,806,316 |
Computer-Interpretable Guideline formalisms. | Implementing Computer-Interpretable Guidelines (CIGs) in active computer-based decision support systems promises to improve the acceptance and application of guidelines in daily practice. The model and underlying language are the core characteristics of every CIG approach. However, currently no standard model or langua... | 18,806,319 |
A constraint-based approach to medical guidelines and protocols. | Medical guidelines and protocols are documents aimed at improving the quality of medical care by offering support in medical decision making in the form of management recommendations based on scientific evidence. Whereas medical guidelines are intended for nation-wide use, and thus omit medical management details that ... | 18,806,330 |
A case of Legionella pneumophila pneumonia followed by invasive aspergillosis. | We report a rare case of Legionella pneumophila pneumonia followed by invasive aspergillosis (IA). Legionellosis was ameliorated by the administration of ciprofloxacin, erythromycin, and corticosteroid as adjunctive therapy. Although intravenous administration of the corticosteroid was effective at reducing severe infl... | 18,806,346 |
Risk factors for SARS infection within hospitals in Hanoi, Vietnam. | We investigated a nosocomial infection of severe acute respiratory syndrome (SARS) in Vietnam in 2003 and attempted to identify risk factors for SARS infection. Of the 146 subjects who came into contact with SARS patients at Hospital A, 43 (29.5%) developed SARS, and an additional 16 (11%) were asymptomatic but SARS-co... | 18,806,349 |
Do serological tests provide adequate rapid diagnosis of Mycoplasma pneumoniae infection? | This study was designed to evaluate the serologic response to Mycoplasma pneumoniae infection. A total of 589 children < or =18 years (190 in the year 2004; 399 in 2005) and 2,073 adults > or = 18 years of age (980 in the year 2004; 1,093 in 2005) with respiratory symptoms underwent serological testing for M. pne... | 18,806,352 |
Case Study: Isolated Anterior lnterosseous Nerve Paralysis: The - Kiloh-Nevin Syndrome. | A new case of isolated paralysis of the anterior interosseous nerve of a 24-year-old man is described. It is thought that this was caused by a fall on the left arm. This paralysis has a typical clinical picture with a characteristic disturbance of the pinch grip. The patient recovered spontaneously. A review of the fin... | 18,806,369 |
lsokinetic Evaluation of Tibial Rotation: Assessment of a Stabilization Technique*. | The purpose of this study was to present a wide range of normative data on maximum active tibial rotation utilizing isokinetic resistance and a relatively new stabilization technique. Both legs of 25 healthy adult male subjects were tested at 30, 60, 120, and 180 degrees per second of angular velocity. Data were collec... | 18,806,380 |
Pain complaint: comparison of electrical stimulation with conventional isometric exercise. | The purpose of this retrospective study was to assess the pain experiences of 17 healthy subjects who trained with isometric exercise, electrical stimulation, and the combination of isometric exercise and electrical stimulation. The McGill Pain Questionnaire was administered during posttest sessions upon termination of... | 18,806,388 |
The effect of physical activity on ligamentous strength: an overview*. | A brief review of the literature pertaining to the strengthening of ligamentous tissue through physical activity is presented. Although literature exists supporting both sides of the question, the predominence of evidence seems to be in favor of improved ligamentous strength following physical activity. Despite the gen... | 18,806,403 |
Use of elbow dynasplint for reduction of elbow flexion contractures: a case study. | A severe elbow flexion contracture following a supracondylar fracture in a 13-yearold- male was treated with conventional physical therapy and an adjustable dynamic splint, the elbow Dynasplint(R). The Dynasplint was applied primarily at night. The patient achieved complete resolution of his flexion contracture. The Dy... | 18,806,405 |
Norms for high school football players derived from cybex data reduction computer. | Three hundred and forty-two male high school football players, ranging in age from 15 to 17, were screened for muscular imbalances and joint abnormalities about the knee using a Cybex II lsokinetic Dynamometer and Cybex Data Reduction Computer. Each player was tested at speeds of 60, 240, 300 degrees , and 300" per sec... | 18,806,406 |
Flexor hallucis longus tendinitis-a case of mistaken identity and posterior impingement syndrome in dancers: evaluation and management. | Flexor hallucis longus tendinitis and posterior impingement syndrome, two problems commonly encountered by dancers, but sometimes misdiagnosed, are presented and discussed in terms of anatomy, evaluation, and management.J Orthop Sports Phys Ther 1984;5(4):204-206. | 18,806,415 |
Survey of scholastic athletic health care and sports medicine clinics. | The increasing number of athletes requiring health care has spurred the growth of the development of sports medicine clinics. The diversity of such clinics is readily apparent. These clinics primarily function to provide evaluative and rehabilitative measures to all groups of athletic participants. Scholastic health ca... | 18,806,428 |
The definition and assessment of muscular power. | Considerable confusion still exists in the sports medicine literature concerning the measurement of muscular power and what it represents. Measures of muscular performance cannot be conveniently categorized as "strength " or ''power" on the basis of the contractile velocity employed in the performance task. Given the p... | 18,806,437 |
Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: a clinicopathological study of 6 cases. | We report 5 cases of spiradenoma and 1 case of spiradenocylindroma, which, in addition to areas of conventional growth, manifested an adenomatous component. This consisted of compactly situated, well-developed glands having small round lumens lined by inner pale to eosinophilic cells and surrounded by an outer well-for... | 18,806,484 |
State of the art of teledermatopathology. | Teledermatopathology may involve real-time transmission of images from distant locations to consulting pathologists by the remote manipulation of a robotic microscope. Alternatively, the static store-and-forward option involves the single-file transmission of subjectively preselected and captured areas of microscopic i... | 18,806,486 |
Immunohistochemical investigation of mid-dermal elastolysis with a history of erythema. | Elastic fibers are essential extracellular matrix macromolecules comprising an elastin core surrounded by fibrillin-rich microfibrils. Fibulin-5, a microfibril, has been identified as one of the secreted extracellular matrix proteins that shows function as a scaffold for elastic fibers. However, the distribution of fib... | 18,806,493 |
Langerhans cell histiocytosis mimicking malignant melanoma: a diagnostic pitfall. | Langerhans cell histiocytosis (LCH), especially with an involvement limited to the skin, is a rare entity in adults. In formulating a differential diagnosis of a solitary skin lesion, LCH is rarely considered. Morphologically, cells seen in LCH can mimic those seen in a melanocytic tumor; moreover, they both show S-100... | 18,806,499 |
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