title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Assessing emergency response training needs of local environmental health professionals. | The Michigan Center for Public Health Preparedness collaborated with environmental health (EH) professionals at the local, state, and national levels to develop and conduct a state-wide study to identify the preparedness-training needs of local EH professionals in Michigan. The specific aims of the study were first, to... | 18,807,819 |
The impact of legislation in Ireland on handheld mobile phone use by drivers. | Under the Road Traffic Act, 2006 handheld mobile phone use whilst driving is an offence liable to a fine and penalty points. The aim of this study was to determine whether there has been a change in driver behaviour following the introduction of this legislation. This study found that 2.3% of drivers were still using a... | 18,807,816 |
A primer in the evaluation of quality in acute care settings. | Nurses are in a unique position to evaluate acute care quality. The authors describe common problems and challenges related to selection of variables and choice of databases for quality evaluations. Practical strategies to address these concerns also are discussed. | 18,807,858 |
[The morbidity of physicians of pre-pensionary age]. | The data research related to the investigation of the morbidity of the physicians of pre-pensionary age on the basis of medical check-up results. It is established that more than 95% of physicians suffered from chronic diseases. At that most of them had several diseases. Among the examined groups of physicians accordin... | 18,807,868 |
[Immunohistochemical analysis of hepatic steatosis in autopsy cases of severe motor and intellectual disabilities]. | To explore the pathogenesis of hepatic steatosis in severe motor and intellectual disabilities (SMID), we immunohistochemically examined the accumulation of oxidative products in 8 autopsy cases of SMID, 5 of which pathologically showed hepatic steatosis. Three of the 8 cases also demonstrated fibrosis in Glisson's she... | 18,807,886 |
[Mitochondrial diseases in children including Leigh syndrome--biochemical and molecular background]. | Mitochondrial diseases in children are more frequently caused by mutations in nuclear DNA then in mtDNA. Special clinical phenotypes are associated with the mutations in SURF1 gene, in SCO2 gene and with mtDNA depletion syndromes. Leigh syndrome is the most common clinical presentation of various mitochondrial disorder... | 18,807,927 |
[Protein kinases in mitochondria]. | Mitochondria, besides playing a central role in energy metabolism within the cell, are involved in a cohort of other processes like cellular differentiation and apoptosis. Investigations during recent few years have shown that protein kinases, including PKA, PKB/Akt, PKC, Raf-1, p38 MAPK, JNK, ERK1/2, Src, Fyn and Csk,... | 18,807,932 |
[Metabolic engineering for improving ethanol fermentation of xylose by wild yeast]. | One yeast strain, which was isolated from 256 natural samples, was found to be able to utilize D-xylose effectively. On the basis of assimilation physiological and molecular biological tests, the yeast strain was identified as a strain of Candida tropicalis. Furthermore, metabolic engineering breeding strategy was appl... | 18,807,975 |
[Gene function and microbial community structure in sulfide minerals bioleaching system based on microarray analysis]. | Biohydrometallergy technology received more and more attention because of its simple process, low cost and kind to environment, especially in dealing with low-grade and complex minerals. However, it is difficult to optimize microorganism species and process parameters in bioleaching procedure because of the lack of sui... | 18,807,978 |
[Isolation and fermentation condition of milk-clotting enzyme producing strain from glutinous rice wine]. | Glutinous rice wine is a traditional food in south of China and it can coagulate milk. It has been proved that its function of coagulating milk is because of the presence of milk-clotting enzyme produced by microorganisms in glutinous rice wine. The aim of this work is to isolate milk-clotting enzyme producing strain f... | 18,807,982 |
[Purification and characterization of extracellular polysaccharides from Nostoc flagelliforme]. | The extracellular polysaccharides (EPS) of N. flagelliforme were purified by DEAE anion exchange chromatography and Sephadex G100 gel filtration chromatography. And two main components named NFPS1 and NFPS2 were obtained respectively. The physico-chemical characteristics of NFPS2 were analyzed and compared with NFPS0, ... | 18,807,987 |
[Dynamics of initial decomposition of Calamagrostis angustifolia litter in Sanjiang Plain of China]. | A 28-day leaching-decomposition experiment was conducted to study the effects of microbial activity and leaching on the initial decomposition of Calamagrostis angustifolia litters taken from the boggy meadow and meadow in Sanjiang Plain of China. The results showed that the mass loss of the litters at their initial dec... | 18,808,011 |
[Chemical forms and ecological effect of soil Mn in liver cancer's high incidence area in Zhu-jiang River Delta, China]. | The samples of surface soil, deep soil, and vegetables were collected from the liver cancer's high- and low incidence areas in Zhujiang River Delta to study the relationships between soil Mn forms and vegetables' Mn enrichment. The results showed that the soil Mn in study area was mainly derived from parent materials, ... | 18,808,033 |
Expression of c-Myc, neurofibromatosis Type 2, somatostatin receptor 2 and erb-B2 in human meningiomas: relation to grades or histotypes. | Meningiomas, which originate from arachnoid cells, represent one of the largest subgroups of intracranial tumors. They are generally benign, but can progress to malignancy. The aim of our study was to determine the expression of 4 genes, c-Myc, neurofibromatosis Type 2 (NF2), somatostatin receptor isoform 2 (sst2) and ... | 18,808,065 |
[Ticks--due to climatic changes, much more than just Ixodes ricinus, TBE and Lyme disease]. | Ectoparasitic arthropodes, like ticks, confer numerous pathogenic bacterial and viral germs upon human beings and/or animals. Since these vectors are poikilothermic, there is a strong dependence on environmental conditions. Climatic as well as microclimatic conditions play a major role. Against this background, it can ... | 18,808,072 |
[Antimycotic therapy of Tinea pedis and other foot mycoses]. | Fungal foot infections belong to the most frequent infectious diseases in industrialized countries. In Germany, an estimated one third of the total adult population is suffering from a mycosis of the foot. In most cases, these infections are caused by a dermatophyte species, especially Trichophyton rubrum and T. mentag... | 18,808,073 |
Oxidation of cyclohexane by a high-valent iron bispidine complex: a combined experimental and computational mechanistic study. | Experimental data suggest that there are various competing pathways for the catalytic and stoichiometric oxygenation of cyclohexane, assisted by iron-bispidine complexes and using various oxidants (H(2)O(2), O(2), PhIO). Density functional theory calculations indicate that both Fe(IV)=O and Fe(V)=O species are accessib... | 18,808,102 |
Near-quantitative internal quantum efficiency in a light-emitting electrochemical cell. | A green-light-emitting iridium(III) complex was prepared that has a photoluminescence quantum yield in a thin-film configuration of almost unity. When used in a simple solid-state single-layer light-emitting electrochemical cell, it yielded an external quantum efficiency of nearly 15% and a power efficiency of 38 Lm/W.... | 18,808,114 |
Electronic structure and magnetism in transition metals doped 8-hydroxy-quinoline aluminum. | We report the room-temperature ferromagnetism in transition metals (Co, Ni)-doped 8-hydroxy-quinoline aluminum (Alq3) by thermal coevaporation of high purity metal and Alq3 powders. For 5% Co-doped Alq3, a maximum magnetization of approximately 0.33 microB/Co at 10 K was obtained and ferromagnetic behavior was observed... | 18,808,121 |
Studies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone. | A stereoselective synthesis of the model aglycone corresponding to the anti-HIV aureolic acids durhamycins A (1) and B (2) is described. | 18,808,128 |
Palladium-catalyzed benzylic arylation of N-benzylxanthone imine. | The direct benzylic arylation of N-benzylxanthone imine with aryl chloride proceeds under palladium catalysis, yielding the corresponding coupling product. The product is readily transformed to benzhydrylamine. Taking into consideration that the imine is readily available from benzylic amine, the overall transformation... | 18,808,130 |
Facile preparation of alpha-aryl nitriles by direct cyanation of alcohols with TMSCN under the catalysis of InX3. | A convenient and efficient synthesis of alpha-aryl nitriles was developed by direct cyanation of alcohols with TMSCN under the catalysis of Lewis acid. Using 5-10 mol % of InBr3 as the catalyst, a variety of benzylic alcohols can be converted to the corresponding nitriles in 5-30 min with yields of 46-99%. | 18,808,133 |
A light-harvesting array composed of porphyrins and rigid backbones. | A light-harvesting array containing rigid backbones, peripherally positioned Zn-porphyrin terminals, and a free-base (Fb) porphyrin core was prepared by a convergent method where the Sonogashira coupling reaction was used in the key steps. Effective intramolecular singlet-energy transfer from the peripheral Zn-porphyri... | 18,808,134 |
Platinum-catalyzed enantioselective tandem alkylation/arylation of primary phosphines. Asymmetric synthesis of P-stereogenic 1-phosphaacenaphthenes. | Enantioselective tandem alkylation/arylation of primary phosphines with 1-bromo-8-chloromethylnaphthalene catalyzed by Pt(DuPhos) complexes gave P-stereogenic 1-phosphaacenaphthenes (AcePhos) in up to 74% ee. Diastereoselective formation of four P-C bonds in one pot with bis(primary) phosphines gave C2-symmetric diphos... | 18,808,136 |
N-(p-dodecylphenylsulfonyl)-2-pyrrolidinecarboxamide: a practical proline mimetic for facilitating enantioselective aldol reactions. | A highly practical and readily available proline surrogate has been developed with improved solubility properties in common, nonpolar organic solvents. This sulfonamide-based catalyst has proven highly effective at facilitating enantioselective and diastereoselective aldol reactions with a range of substrates in nonpol... | 18,808,137 |
Angiotensin I-converting enzyme-inhibitory peptides obtained from chicken collagen hydrolysate. | In this study, collagen extracted from chicken legs (which are the yellow keratin parts containing a nail) was hydrolyzed with various enzymes, and the angiotensin I-converting enzyme (ACE)-inhibitory activity of each hydrolysate was determined. The hydrolysate by treatment with an Aspergillus species-derived enzyme ha... | 18,808,143 |
Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1. | The roots of Angelica sinensis (Oliv.) Diels (Dang Gui; Apiaceae) have a long history in traditional Chinese medicine as a remedy for women's disorders and are often called "lady's ginseng". Currently, extracts of A. sinensis are commonly included in numerous dietary supplements used for women's health and as antiaging... | 18,808,158 |
Metallic cation induced one-dimensional assembly of poly(acrylic acid)-1-dodecanethiol-stabilized gold nanoparticles. | In this work, we report a simple approach for controllable synthesis of one-dimensional (1D) gold nanoparticle (AuNP) assemblies in solution. In the presence of divalent metallic ions, poly(acrylic acid)-1-dodecanethiol-stabilized AuNPs (PAA-DDT@AuNPs) are found to form 1D assemblies in aqueous solution by an ion-templ... | 18,808,165 |
A new similarity found from the correspondence of the critical and Zeno-line parameters. | We find a new similarity based on the relation between the critical and unit compressibility line (Zeno-line) parameters. Our study relies on the fact that the Zeno-line must be tangential to the extension of the binodal liquid branch at the zero temperature domain. We show that this similarity faithfully describes bot... | 18,808,178 |
Functionalization of multiwalled carbon nanotubes by pyrene-labeled hydroxypropyl cellulose. | Pyrene-labeled hydroxypropyl cellulose (HPC-Py) was synthesized through a condensation reaction between hydroxypropyl cellulose (HPC) and 1-pyrenebutyric acid (Py). A hybrid (HPC/MWNTs) of the HPC-Py and multiwalled carbon nanotubes (MWNTs) was prepared through a noncovalent method. Temperature-variable UV-vis spectra ... | 18,808,180 |
Structure and molecular mobility of soy glycinin in the solid state. | We report a multitechnique study of structural organization and molecular mobility for soy glycinin at a low moisture content (<30% w/w) and relate these to its glass-to-rubber transition. Small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, an... | 18,808,181 |
Cotunneling model for current-induced events in molecular wires. | Many phenomena in molecular transport junctions involve transitions between electronic states of the molecular wire, and, therefore, cannot be described adequately using the Landauer picture. We present a model for cotunneling processes in molecular wires. These are coherent second-order processes that can be observed ... | 18,808,190 |
Managing discrimination in selection: the influence of directives from an authority and social dominance orientation. | The authors examined one manner in which to decrease the negative impact of social dominance orientation (SDO), an individual difference variable that indicates support for the "domination of 'inferior' groups by 'superior' groups" (J. Sidanius & F. Pratto, 1999, p. 48), on the selection of candidates from low-stat... | 18,808,220 |
Collaborative coping and daily mood in couples dealing with prostate cancer. | Collaborative coping (i.e., spouses pooling resources and problem solving jointly) may be associated with better daily mood because of heightened perceptions of efficacy in coping with stressful events. The study examined the daily processes of collaborative coping (individuals' perceptions that the spouse collaborated... | 18,808,241 |
Oh, honey, I already forgot that: strategic control of directed forgetting in older and younger adults. | Two experiments investigated list-method directed forgetting with older and younger adults. Using standard directed forgetting instructions, significant forgetting was obtained with younger but not older adults. However, in Experiment 1 older adults showed forgetting with an experimenter-provided strategy that induced ... | 18,808,251 |
Not so ugly after all: when shame acts as a commitment device. | Most psychological theories and research on shame focus on the ugly aspects and negative consequences of this emotion. Theories on moral emotions, however, assume that shame acts as a commitment device motivating prosocial behavior. To solve this apparent paradox, the authors studied the effects of shame on prosocial b... | 18,808,269 |
Mechanisms of muscle degeneration, regeneration, and repair in the muscular dystrophies. | To withstand the rigors of contraction, muscle fibers have specialized protein complexes that buffer against mechanical stress and a multifaceted repair system that is rapidly activated after injury. Genetic studies first identified the mechanosensory signaling network that connects the structural elements of muscle an... | 18,808,326 |
Safety and immunogenicity of an inactivated influenza A/H5N1 vaccine given with or without aluminum hydroxide to healthy adults: results of a phase I-II randomized clinical trial. | Dose-sparing strategies are being explored for vaccines against pandemic influenza. We evaluated the dose-sparing potential of aluminum hydroxide (AlOH) adjuvant. A total of 600 healthy subjects (age, 18-49 years) were randomized to receive 2 vaccinations 1 month apart with subvirion inactivated influenza A/H5N1 vaccin... | 18,808,338 |
Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078. | Since 2005, an increase in the prevalence of Clostridium difficile infection (CDI) due to polymerase chain reaction ribotype 078 has been noticed in The Netherlands. This strain has also been identified as the predominant strain in pigs and calves. CDI caused by type 078 was studied in relation to CDI caused by the hyp... | 18,808,358 |
Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice. | Mycobacterium tuberculosis and other pathogenic mycobacterial species produce large amounts of a glycogen-like alpha-glucan that represents the major polysaccharide of their outermost capsular layer. To determine the role of the surface-exposed glucan in the physiology and virulence of these bacteria, orthologues of th... | 18,808,383 |
The genome of Rhodobacter sphaeroides strain 2.4.1 encodes functional cobinamide salvaging systems of archaeal and bacterial origins. | Bacteria and archaea use distinct pathways for salvaging exogenous cobinamide (Cbi), a precursor of adenosylcobalamin (coenzyme B(12)). The bacterial pathway depends on a bifunctional enzyme with kinase and guanylyltransferase activities (CobP in aerobic adenosylcobalamin synthesizers) to convert adenosylcobinamide (Ad... | 18,808,385 |
Risky business: perceived behavior of local scientists and community support for their research. | Attracting new technologies to a region can mean significant economic growth, so understanding why some communities may not favor becoming "the next Silicon Valley" merits consideration. This study investigates the relationship among the perceived behavior of local scientists and community members' attitudes toward the... | 18,808,391 |
Parameters of a dose-response model are on the boundary: what happens with BMDL? | It is well known that, under appropriate regularity conditions, the asymptotic distribution for the likelihood ratio statistic is chi(2). This result is used in EPA's benchmark dose software to obtain a lower confidence bound (BMDL) for the benchmark dose (BMD) by the profile likelihood method. Recently, based on work ... | 18,808,395 |
Adjunctive lithium treatment in the prevention of suicidal behaviour in depressive disorders: a randomised, placebo-controlled, 1-year trial. | Evidence based on controlled studies is still limited for treatment strategies that prevent recurrence of suicide attempts. Findings from observational as well as meta-analytic studies strongly suggest that lithium may have suicide-protective properties. Patients with a recent suicide attempt in the context of an affec... | 18,808,400 |
COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life. | A functional polymorphism in the catechol-o-methyltransferase gene (COMT Val(158)Met) may moderate the psychosis-inducing effects of cannabis. In order to extend this finding to dynamic effects in the flow of daily life, a momentary assessment study of psychotic symptoms in response to cannabis use was conducted. The e... | 18,808,401 |
Does a nerve-sparing technique or potency affect continence after open radical retropubic prostatectomy? | To characterize the effect of preserving the neurovascular bundle (NVB) and of potency on urinary continence after open radical retropubic prostatectomy (ORRP). Between October 2000 to September 2005, 1110 consecutive continent men had ORRP by one surgeon. The University of California Los Angeles Prostate Cancer Index ... | 18,808,410 |
Incidence of primary cutaneous T-cell lymphoma in Norway. | Studies from different countries have reported an increased incidence of primary cutaneous lymphomas over the last decades. To estimate the incidence rates of primary cutaneous T-cell lymphoma (CTCL) and mycosis fungoides (MF)/Sézary syndrome (SS) in Norway, and to compare these rates with those reported from other cou... | 18,808,419 |
Levetiracetam in absence epilepsy. | The aim of the study was to assess the efficacy, tolerability, and safety of levetiracetam therapy in children and adolescents with absence epilepsy. Twenty-one participants (11 male, 10 female) with typical absence seizures were enrolled in this prospective study from seven centres in Italy. The mean age and age range... | 18,808,424 |
Mechanisms of Zn2+ efflux in cultured cortical neurons. | Zinc dyshomeostasis in brain might be involved in the pathogenesis of brain diseases such as Alzheimer's disease and stroke. Resting neurons tightly regulate and maintain low to subnanomolar levels of intracellular free Zn2+, but mechanisms of normal Zn2+ homeostasis are poorly understood. In this study, the mechanisms... | 18,808,447 |
Type-B monogalactosyldiacylglycerol synthases are involved in phosphate starvation-induced lipid remodeling, and are crucial for low-phosphate adaptation. | Mono- and digalactosyldiacylglycerol (MGDG and DGDG, respectively) constitute the bulk of membrane lipids in plant chloroplasts. Mutant analyses in Arabidopsis have shown that these galactolipids are essential for chloroplast biogenesis and photoautotrophic growth. Moreover, these non-phosphorous lipids are proposed to... | 18,808,455 |
An N-terminal diacidic motif is required for the trafficking of maize aquaporins ZmPIP2;4 and ZmPIP2;5 to the plasma membrane. | Maize plasma membrane aquaporins (ZmPIPs, where PIP is the plasma membrane intrinsic protein) fall into two groups, ZmPIP1s and ZmPIP2s, which, when expressed alone in mesophyll protoplasts, are found in different subcellular locations. Whereas ZmPIP1s are retained in the endoplasmic reticulum (ER), ZmPIP2s are found i... | 18,808,456 |
Violence and drug use in rural teens: national prevalence estimates from the 2003 Youth Risk Behavior Survey. | The purpose of this study was to compare national estimates of drug use and exposure to violence between rural and urban teens. Twenty-eight dependent variables from the 2003 Youth Risk Behavior Survey were used to compare violent activities, victimization, suicidal behavior, tobacco use, alcohol use, and illegal drug ... | 18,808,475 |
Acute migraine medications and evolution from episodic to chronic migraine: a longitudinal population-based study. | Though symptomatic medication overuse is believed to play a major role in progression from episodic to chronic or transformed migraine (TM), population-based longitudinal data on these agents are limited. To assess the role of specific classes of acute medications in the development of TM in episodic migraine (EM) suff... | 18,808,500 |
Cellular expression of Bcl-2 and Bax in atrophic submandibular glands of rats. | In submandibular gland atrophy, most acinar cells disappear by apoptosis, while many duct cells remain. The present study aimed to establish whether Bcl-2 and Bax, members of the Bcl-2 gene family, regulating the signalling pathway of apoptosis were involved in duct cell survival and acinar cell death in atrophic subma... | 18,808,524 |
Informed consent and medical ordeal: a qualitative study. | Informed consent is a mainstay of clinical practice, with both moral and legal forces. Material disclosure about extreme treatments, however, is unlikely to convey the full impact of the experience of treatment. Informed consent may be flawed under such circumstances. The aims of this study were to compare expressed sa... | 18,808,560 |
Self-reported competence of home nursing staff in Finland. | This paper is a report of a study to investigate the self-reported competence of home nursing staff and whether this is associated with their education, job descriptions, access to help and support and with factors in their psychosocial work environment, such as opportunities for personal growth and development at work... | 18,808,590 |
Renal net acid excretion capacity is comparable in prepubescence, adolescence, and young adulthood but falls with aging. | To evaluate whether renal net acid excretion capacity (NAEC) varies across different age groups and, specifically, whether it falls in elderly people. Cross-sectional observational study. Community-based. Young participants were from the DOrtmund Nutritional and Anthropometric Longitudinally Designed Study, Dortmund, G... | 18,808,599 |
A traditional Chinese herbal medicine used to treat dysmenorrhoea among Taiwanese women. | The purposes of this study were twofold, firstly to ascertain the relative effectiveness of the alternative drug, Si-Wu-Tang (SWT), for dysmenorrhoea treatment and secondly to compare two different timings for consumption of SWT in terms of menstrual pain. A two-group time series experimental design. A total of 49 part... | 18,808,624 |
Magnetic resonance imaging traits in siblings discordant for Alzheimer disease. | Magnetic resonance imaging (MRI) can aid clinical assessment of brain changes potentially correlated with Alzheimer disease (AD). MRI traits may improve our ability to identify genes associated with AD-outcomes. We evaluated semi-quantitative MRI measures as endophenotypes for genetic studies by assessing their associa... | 18,808,654 |
Generation of diverse neuronal subtypes in cloned populations of stem-like cells. | The central nervous tissue contains diverse subtypes of neurons with characteristic morphological and physiological features and different neurotransmitter phenotypes. The generation of neurons with defined neurotransmitter phenotypes seems to be governed by factors differently expressed along the anterior-posterior an... | 18,808,670 |
pi-Turns: types, systematics and the context of their occurrence in protein structures. | For a proper understanding of protein structure and folding it is important to know if a polypeptide segment adopts a conformation inherent in the sequence or it depends on the context of its flanking secondary structures. Turns of various lengths have been studied and characterized starting from three-residue gamma-tu... | 18,808,671 |
Model-driven analysis of experimentally determined growth phenotypes for 465 yeast gene deletion mutants under 16 different conditions. | Understanding the response of complex biochemical networks to genetic perturbations and environmental variability is a fundamental challenge in biology. Integration of high-throughput experimental assays and genome-scale computational methods is likely to produce insight otherwise unreachable, but specific examples of ... | 18,808,699 |
Role of sphingosine 1-phosphate receptor expression in eosinophils of patients with allergic rhinitis, and effect of topical nasal steroid treatment on this receptor expression. | Recent research has indicated that sphingosine 1-phosphate plays a role in allergy. This study examined the effect of allergen challenge on the expression of sphingosine 1-phosphate receptors on the eosinophils of allergic rhinitis patients, and the effect of steroid treatment on this expression. A prospective, non-ran... | 18,808,729 |
Physician, affective, and cognitive variables differentially predict 'initiation' versus 'maintenance' PSA screening profiles in diverse groups of men. | To evaluate the relevance of demographic, physician, and psychological characteristics to PSA screening in ethnic subpopulations and ascertain whether the same characteristics distinguish men who have never had a PSA from those who screen infrequently and those who screen yearly (adhere). Stratified cluster-sampling wa... | 18,808,732 |
In vitro evaluation of the cytotoxicity and genotoxicity of resorcylidene aminoguanidine in human diploid cells B-HNF-1. | RAG belongs to appropriate inhibitors of protein glycation, i.e. formation of advanced glycation end products, which are thought to be responsible for some complications of DM, including neuropathy, angiopathy, retinopathy and nephropathy. In the present study authors have evaluated the genotoxic effect of RAG on the c... | 18,808,735 |
[The immune system and the eye]. | The special relationship between the eye and the immune system rests on a number of anatomical, physiological and immunological mechanisms. These mechanisms prevent the delicate structures of the eye from potentially damaging immunogenic inflammation while protecting against pathogens. Rather than inflammation, antigen... | 18,808,747 |
[Tumour stem cells in glioma--tomorrow's therapeutic target?]. | Despite intensive research, gliomas still lead to death in most cases. The isolation of brain tumour stem cells from gliomas has paved the way for a growing body of evidence suggesting that these cells are responsible for the resistance of gliomas towards conventional therapy. Recent results suggest that the growth of ... | 18,808,750 |
[Ocular disturbances in neuromuscular disorders]. | Compared with other skeletal muscles, extraocular muscles have fundamentally distinct properties that make them selectively vulnerable to certain neuromuscular disorders. When the oculomotor signs are predominant, their temporal progression allows the clinician to make the distinction between a muscular disease (mitoch... | 18,808,764 |
[Polyradiculopathy revealing an enteropathy associated T-cell lymphoma in a patient with celiac disease]. | Celiac disease (CD) may be complicated by an enteropathy associated T-cell lymphoma (EATL), but lymphomatous dissemination outside the gastrointestinal tract is uncommon especially to the peripheral nervous sytem. We report a 54-year-old CD patient with EATL revealed by subacute polyradiculopathy. Peripheral neuropathi... | 18,808,770 |
The survival impact of the choice of surgical procedure after ipsilateral breast cancer recurrence. | Many women with breast cancer recurrence previously treated with breast-conservation therapy desire repeat lumpectomies. We hypothesized that women undergoing mastectomy for breast cancer recurrence would show superior survival. Patients who previously received breast-conservation therapy diagnosed with an ipsilateral ... | 18,809,050 |
Immediate latissimus dorsi miniflap volume replacement for partial mastectomy: use of intra-operative frozen sections to confirm negative margins. | Latissimus dorsi (LD) miniflap volume replacement is used for immediate reconstruction after partial mastectomy. This prospectively collected series was analyzed to evaluate the accuracy of intraoperative frozen sections. After partial mastectomy, "bed biopsies" were submitted for intraoperative frozen-section analysis... | 18,809,053 |
Optimal treatment of multiple ipsilateral primary breast cancers. | The success of breast-conservation therapy (BCT) for patients with multiple ipsilateral invasive breast cancers (MIBC) is sparsely documented. A retrospective review of single-institution experience. Patients with 2 or more invasive cancers separated by normal breast tissue were included; patients with 1 invasive cance... | 18,809,057 |
Nipple-sparing mastectomy--initial experience at a tertiary center. | Nipple-sparing mastectomy (NSM) combines skin-sparing mastectomy with preservation of the nipple-areolar dermis and intraoperative pathologic assessment of the nipple core. We evaluated our initial experience with NSM in terms of clinical outcomes. An Institutional Review Board-approved retrospective review of patients... | 18,809,066 |
Epidemiology of anemia in older adults. | Anemia is a common, multifactorial condition among older adults. The World Health Organization (WHO) definition of anemia (hemoglobin concentration <12 g/dL in women and <13 g/dL in men) is most often used in epidemiologic studies of older adults. More than 10% of community-dwelling adults age 65 years and older ... | 18,809,090 |
Renal disease and anemia in the elderly. | As individuals age, the incidence of both renal insufficiency and anemia increases. Some of the changes in renal function can be traced to age-related alterations in the renal vasculature that may dissociate renal blood flow from glomerular filtration. In addition, there appear to be paradoxical changes in renal produc... | 18,809,093 |
Associations between psychiatric disorders and menstrual cycle characteristics. | An understanding of the relationship between psychiatric disorders and menstrual characteristics is important to the assessment and care of women. Menstrual cycle regularity and length have significant associations with specific current and lifetime psychiatric disorders. The purpose of this study was to investigate wh... | 18,809,118 |
Global health opportunities in surgery: a guide for medical students and faculty. | A four-week surgical rotation at the Clinica Universitaria Teleton in Chia, Colombia, was arranged for a U.S. student at the completion of the first year of medical school. The rotation resulted in a supervised intense early clinical exposure to surgery resulting in advancement in five of the six clinical competencies.... | 18,809,171 |
Electron beam triggered, free radical polymerization-derived monolithic capillary columns for high-performance liquid chromatography. | Monolithic capillary columns were prepared via electron beam triggered free radical polymerization within the confines of 0.2 and 0.1mm I.D. capillary columns using ethyl methacrylate and trimethylolpropane triacrylate as monomers as well as 2-propanol, 1-dodecanol and toluene as porogenic system. The influence of colu... | 18,809,181 |
Demyelinating polyneuropathy with focally folded myelin sheaths in a family of Miniature Schnauzer dogs. | A spontaneous demyelinating polyneuropathy in two young Miniature Schnauzer dogs was characterized clinically, electrophysiologically and histopathologically. Both dogs were related and a third dog, belonging to the same family, had similar clinical signs. On presentation, clinical signs were restricted to respiratory ... | 18,809,183 |
Mansonella perstans filariasis in Uganda: patterns of microfilaraemia and clinical manifestations in two endemic communities. | Surveys for Mansonella perstans infection and potentially related clinical manifestations were undertaken in two endemic communities in Mukono and Luwero districts of Uganda where no other human filarial infections are transmitted. A sensitive and accurate counting chamber method was used for quantifying microfilaraemi... | 18,809,192 |
Modulation of redox pathways in neutrophils from sickle cell disease patients. | Interaction of nitric oxide (NO) with enzymatic sources of reactive species exerts modulatory actions on inflammatory signaling mechanisms. NADPH oxidase, total peroxidase, cyclooxygenase (COX) activity, and NO consumption were measured in neutrophils isolated from sickle cell disease (SCD) patients and healthy control... | 18,809,239 |
Characterization of TiO(2)-chitosan/glass photocatalyst for the removal of a monoazo dye via photodegradation-adsorption process. | In this paper, the newly explored TiO(2)-Chitosan/Glass was suggested as a promising alternative material to conventional means of wastewater treatment. Characterization of TiO(2)-Chitosan/Glass photocatalyst was studied with SEM-EDX, XRD, and Fourier transform infrared spectroscopy (FTIR) analysis. The combination eff... | 18,809,254 |
Dynamic aortic changes in patients with thoracic aortic aneurysms evaluated with electrocardiography-triggered computed tomographic angiography before and after thoracic endovascular aneurysm repair: preliminary results. | The purpose of this study was to utilize dynamic computed tomographic angiography (CTA) on pre- and postoperative thoracic endovascular aneurysm repair (TEVAR) patients to characterize cardiac pulsatility-induced aortic motion on essential TEVAR proximal sealing zones and to study the influence of endograft placement. ... | 18,809,281 |
Arteriovenous graft with outflow in the proximal axillary vein. | Arteriovenous access can result in complications including extremity ischemia and swelling. Use of the nondominant upper extremity is preferred because complications will result in less severe disability. The distal axillary vein in the axilla is usually considered to be the end point for arteriovenous access in the up... | 18,809,289 |
Type A intramural hematoma presenting with acute right heart failure caused by compression of the main pulmonary artery: a case report. | Pulmonary artery obstruction is a rare complication of intramural hematoma of the ascending aorta. There were few reported cases presenting with right heart failure due to compression of the pulmonary trunk by intramural hematoma of the aorta. | 18,809,295 |
Marine diatoms as optical biosensors. | We have chemically modified the frustules of the marine diatom Coscinodiscus concinnus Wm. Smith to properly bind a highly selective bioprobe such as an antibody. By measuring the changes in the photoluminescence emission of diatoms frustules, we have monitored the molecular recognition event between the antibody and i... | 18,809,311 |
Biodiesel production by in situ transesterification of municipal primary and secondary sludges. | The potential of using municipal wastewater sludges as a lipid feedstock for biodiesel production was investigated. Primary and secondary sludge samples obtained from a municipal wastewater treatment plant in Tuscaloosa, AL were freeze-dried and subjected to an acid-catalyzed insitu transesterification process. Experim... | 18,809,323 |
Extensive NMRD studies of Ni(II) salt solutions in water and water-glycerol mixtures. | Aqueous solutions of simple nickel(II) salts are a classical test case for theories of the paramagnetic relaxation enhancement (PRE) and its dependence on the magnetic field (nuclear magnetic relaxation dispersion, NMRD), going back to late fifties. We present here new experimental data, extending the NMRD range up to ... | 18,809,345 |
Insulin-like growth factor-I reduces stress-induced gastric mucosal injury by inhibiting neutrophil activation in mice. | We previously reported that activated neutrophils are critically involved in the development of stress-induced gastric mucosal injury in mice. Caspase activation plays an important role in the pathogenesis of tissue injury by activating neutrophils through an increase in the expression of endothelial monocyte-activatin... | 18,809,348 |
A reliable confirmation of the chemical structure of synthetic oligonucleotides: detection of active protons in DNA oligomers by low-temperature FT infrared spectroscopy. | Cooling the samples allowed us to characterize solid oligonucleotides such as dimers, trimers and pentamers of cytidine, for the first time, in the IR range of the out-of-plane bending molecular modes (1000-400 cm(-1)) at 20K. Especially interesting are the narrow IR bands of the out-of-plane bending nu(4) NH(2) proton... | 18,809,351 |
Regulation of brain insulin mRNA by glucose and glucagon-like peptide 1. | Whether the brain synthesizes insulin is currently debated. Two clonal, immortalized mouse hypothalamic cell lines from e17, mHypoE-39 and mHypoE-46, express insulin 2 (Ins2), but not Ins1. We analyzed regions necessary for basal gene activity and found that the mouse Ins2 region -110/+183 bp stimulates promoter activi... | 18,809,381 |
Assessment of anxiety-like behaviors in female rats bred for differences in kindling susceptibility and amygdala excitability. | Two rat lines bred for kindling susceptibility were previously observed to engage in different behavioral strategies in tests of emotionality. In order to extend past research on defensive behaviors in these strains which largely used males, Fast- and Slow-kindling females were assessed for anxiety-like behaviors in a ... | 18,809,390 |
Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy. | The study investigates if alpha-lipoic acid is neuroprotective against chemotherapy induced neurotoxicity, if mitochondrial damage plays a critical role in toxic neurodegenerative cascade, and if neuroprotective effects of alpha-lipoic acid depend on mitochondria protection. We used an in vitro model of chemotherapy in... | 18,809,400 |
Physiological stress response of young adults exposed to bullying during adolescence. | Peer victimization in the form of bullying is a chronic social stressor experienced by many humans during development. Exposure to bullying has been associated with a variety of mental disorders, such as anxiety and depression. Participants pre-selected for the presence or absence of a history of being bullied were bro... | 18,809,422 |
The function of rhamnose-binding lectin in innate immunity by restricted binding to Gb3. | L-rhamnose-binding lectins (RBLs) have been isolated from various kinds of fish and invertebrates and interact with various kinds of bacteria, suggesting RBLs are involved in various inflammatory reactions. We investigated the effect of RBLs from chum salmon (Oncorhynchus keta), named CSL1, 2 and 3, on the peritoneal m... | 18,809,432 |
Striatal volume differences between non-human and human primates. | Convection-enhanced delivery (CED) has recently entered the clinic and represents a promising new delivery option for targeted gene therapy in Parkinson's disease (PD). The prime stereotactic target for the majority of recent gene therapy clinical trials has been the human putamen. The stereotactic delivery of therapeu... | 18,809,434 |
Complex dynamics of microbial competition in the gradostat. | We examine the conditions necessary for the emergence of complex dynamic behavior in systems of microbial competition. In particular, we study the effect of spatial heterogeneity and substrate-inhibition on the dynamics of such a system. This is accomplished through the study of a mathematical model of two microbial po... | 18,809,443 |
Effects of dietary selenium supplementation on serum and liver selenium, serum malondialdehyde and liver glutathione peroxidase activity in rats consuming thermally oxidized sunflower oil. | The present study compared the effects of four isocaloric diets containing (1) fresh sunflower oil not supplemented with selenium (Fresh), (2) oxidized sunflower oil not supplemented with selenium (Oxidized), (3) fresh sunflower oil supplemented with 1 ppm selenium as sodium selenite (Fresh+Se), (4) oxidized sunflower ... | 18,809,457 |
FGF-8 stimulates the expression of NR4A orphan nuclear receptors in osteoblasts. | Nurr1, NGFI-B, and Nor1 form the NR4A subfamily of orphan nuclear receptors. The NR4A receptors are immediate early genes that can be rapidly induced in response to a variety of stimuli in many cell types, for example, in osteoblasts. Nurr1 regulates the differentiation of osteoblasts and the expression of several oste... | 18,809,462 |
The energy hypothesis of sleep revisited. | One of the proposed functions of sleep is to replenish energy stores in the brain that have been depleted during wakefulness. Benington and Heller formulated a version of the energy hypothesis of sleep in terms of the metabolites adenosine and glycogen. They postulated that during wakefulness, adenosine increases and a... | 18,809,461 |
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