title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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[High rate of hepatitis B virus DNA positivity in anti-HBc only-positive patients]. | In hepatitis B virus (HBV) infections, detection of only anti-HBc in the absence of HBsAg and anti-HBs is known as 'anti-HBc only' situation. In this study we investigated the rate of HBV-DNA positivity in anti-HBc only-positive 45 patients (29 male, 16 female; mean age: 39.2 +/- 12.3 years) who were followed in the ou... | 18,822,901 |
[Effect of sodium ferulate on hemodynamics in hepatic cirrhosis patients with portal hypertension]. | To observe the effect of sodium ferulate on the hemodynamics of hepatic cirrhosis patients. Eighty-two hepatic cirrhosis patients were randomly assigned to two groups, the 27 patients in the control group were treated by conventional liver protecting therapy, and the 55 patients in the treated group were treated with s... | 18,822,917 |
[Effect of retention enema with combination of compound glutamine entero-soluble capsule and glucocorticoids for treatment of ulcerative colitis]. | To observe the therapeutic effect and safety of retention enema with compound glutamine entero-soluble Capsule (CGC) on active ulcerative colitis (UC). One hundred and sixty-eight patients with active UC were randomly assigned to the treatment group (86 patients) and the control group (82 patients). Besides the basic t... | 18,822,919 |
Peak expiratory flow rate of rural school children from Wardha district, Maharashtra in India. | Peak expiratory flow rate (PEFR) recording is an essential measure in the management and evaluation of asthmatic children. The PEFR can be measured by a simple instrument--peak expiratory flow meter. The aim of this study was to determine the normal PEFR in rural school children from Wardha district of Maharashtra stat... | 18,822,931 |
[Quality of life in multiple sclerosis: relation to the clinical parameters of the disease]. | Multiple sclerosis is a chronic progressive disease with multiple neurological and psychological impairments. The object of this study was to investigate the relation between quality of life of MS patients and main clinical parameters of the disease. The study included 100 patients diagnosed with multiple sclerosis who... | 18,822,940 |
[Dihydroartemisinin down-regulates the expression of transferrin receptor in myeloid leukemia cells]. | This article reports the effect of dihydroartemisinin (DHA) on transferrin receptor (TfR) in myeloid leukemia cells by establishing the model of normal iron HL60 and K562 cells and iron overload K562 cells in vitro. The TfR content of myeloid leukemia cells was determined by flow cytometry, and the effect of DHA on iro... | 18,822,958 |
[Synthesis and central none-opioid analgesic activity of SIPI5047]. | Compound SIPI5047 was synthesize by using piperazine as starting material in five reaction steps, and its central none-opioid analgesic activity was studied. Its analgesic activity, pharmacological mechanism, action type and drug dependence were well studied in vivo and in vitro. The results show that SIPI5047 has pote... | 18,822,964 |
[Advances of studies on acupuncture reinforcing-reducing of twirling-rotating the needle]. | The theories and clinical and experimental studies about reinforcing-reducing manipulation of twirling rotating the needle in recent 15 years are reviewed and a brief account of manipulation methods, mechanisms and effects of reinforcing-reducing manipulation of twirling-rotating the needle is given, and it is indicate... | 18,822,992 |
Sequenced Treatment Alternatives to Relieve Depression (STAR*D). Part 1: study design. | This article describes the design of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. The main study objective was to compare the efficacy and tolerability of various antidepressant therapies through four sequential treatment levels. To maximize the generalizability of the results, broad inclu... | 18,822,996 |
Risk of radiation-related salivary gland carcinomas among survivors of Hodgkin lymphoma: a population-based analysis. | Radiotherapy for Hodgkin lymphoma (HL) increases the risk of salivary gland carcinomas (SGC). To the authors' knowledge, however, the magnitude of the risk has not been assessed to date. The risks of SGC among 20,928 1-year survivors of HL who were diagnosed between 1973 and 2003 were evaluated in 11 population-based c... | 18,823,043 |
Clinical and genetic characterization of a large Dutch family with primary focal dystonia. | We describe a large family with a primary focal dystonia from a small Dutch village on a former island. Twenty-four individuals spanning three generations were examined by two movement-disorder neurologists. Two other movement-disorder neurologists evaluated the videos independently. Subjects were classified as "affect... | 18,823,044 |
Monitoring intracellular labile iron pools: A novel fluorescent iron(III) sensor as a potential non-invasive diagnosis tool. | The physiological and pathophysiological importance of intracellular redox active "labile" iron has created a significant need for improved noninvasive diagnostic tools to reliably monitor iron metabolism in living cells. In this context, fluorescent iron-sensitive chemosensors in combination with digital fluorescence ... | 18,823,046 |
Brief exposure of Blattella germanica (Blattodea) to insecticides formulated in various microcapsule sizes and applied on porous and non-porous surfaces. | The authors explored how microcapsule size and brief exposure affected the bioavailability of five microencapsulated insecticide formulations, chlorpyrifos 23.1 g L(-1) CS (Detmol-PRO), chlorpyrifos 20 g L(-1) CS (Empire 20), fenitrothion 20 g L(-1) CS (Detmol-Mic), cyphenothrin 10 g L(-1) CS (Detmol-CAP) and diazinon ... | 18,823,064 |
Correlation between the molecular structure and photoresponse in aliphatic self-assembled monolayers with azobenzene tailgroups. | We have compared the structural and photoisomerization properties of self-assembled monolayers (SAMs) comprising either the trans or cis isomers of azobenzene terminated dithiolane with in-chain amide unit, viz., 4-(phenyldiazenyl)phenyl-4-(1,2-dithiolane-3-yl)-butylcarboxamide ( 1). These films were prepared on Au(111... | 18,823,085 |
Confinement of DNA in water-in-oil microemulsions. | The study of systems that allow DNA condensation in confined environments is an important task in producing cell-mimicking microreactors capable of biochemical activities. The water droplets formed in water-in-oil emulsions are potentially good candidates for such microcompartments. The anionic surfactant AOT was used ... | 18,823,088 |
Hippocampal response patterns during discriminative eyeblink/jaw movement conditioning in the rabbit. | Rabbits were given concurrent training in eyeblink (EB) and jaw movement (JM) conditioning in which 1 tone predicted an airpuff and another tone predicted water. After 10 days of discrimination training, the animals were given 10 days of reversal training. In the discrimination phase, acquisition of the 2 conditioned r... | 18,823,166 |
Neural dynamics underlying impaired autonomic and conditioned responses following amygdala and orbitofrontal lesions. | A neural model is presented that explains how outcome-specific learning modulates affect, decision-making, and Pavlovian conditioned approach responses. The model addresses how brain regions responsible for affective learning and habit learning interact and answers a central question: What are the relative contribution... | 18,823,167 |
Nicotine enhances context learning but not context-shock associative learning. | Nicotine has been found to enhance learning in a variety of tasks, including contextual fear conditioning. During contextual fear conditioning animals have to learn the context and associate the context with an unconditioned stimulus (footshock). As both of these types of learning co-occur during fear conditioning, it ... | 18,823,171 |
What does it take to demonstrate memory erasure? Theoretical comment on Norrholm et al. (2008). | An issue of increasing interest in Pavlovian conditioning is to identify ways to facilitate the development and persistence of extinction. Both behavioral and molecular lines of evidence demonstrate that learning during extinction can be enhanced. Similar evidence has been offered to support the idea that extinction ca... | 18,823,175 |
Object substitution masking: when does mask preview work? | When a target is enclosed by a 4-dot mask that persists after the target disappears, target identification is worse than it is when the mask terminates with the target. This masking effect is attributed to object substitution masking (OSM). Previewing the mask, however, attenuates OSM. This study investigated specific ... | 18,823,198 |
Active gaze, visual look-ahead, and locomotor control. | The authors examined observers steering through a series of obstacles to determine the role of active gaze in shaping locomotor trajectories. Participants sat on a bicycle trainer integrated with a large field-of-view simulator and steered through a series of slalom gates. Steering behavior was determined by examining ... | 18,823,202 |
Impairments in the perception of odor-induced tastes and their relationship to impairments in taste perception. | Certain odors have tastelike qualities when sniffed. To the extent that these qualities are akin to real taste experiences, impairment in perception of odor-induced tastes should be accompanied by taste impairment, and vice versa. Twelve patients were selected with possible odor-induced taste impairments or general tas... | 18,823,204 |
Combination antiplatelet agents for secondary prevention of ischemic stroke. | Stroke is a leading cause of death and the primary cause of serious, long-term disability in the United States. Joint guidelines from the American Heart Association (AHA) and American Stroke Association (ASA), as well as recent guidelines from the Eighth American College of Chest Physicians (ACCP) Conference on Antithr... | 18,823,219 |
Conceptual processing in music as revealed by N400 effects on words and musical targets. | The cognitive processing of concepts, that is, abstract general ideas, has been mostly studied with language. However, other domains, such as music, can also convey concepts. Koelsch et al. [Koelsch, S., Kasper, E., Sammler, D., Schulze, K., Gunter, T., & Friederici, A. D. Music, language and meaning: Brain signatu... | 18,823,240 |
Neural correlates of stimulus reportability. | Most experiments on the "neural correlates of consciousness" employ stimulus reportability as an operational definition of what is consciously perceived. The interpretation of such experiments therefore depends critically on understanding the neural basis of stimulus reportability. Using a high volume of fMRI data, we ... | 18,823,251 |
Transgene expression of green fluorescent protein and germ line transmission in cloned pigs derived from in vitro transfected adult fibroblasts. | The pig represents the xenogeneic donor of choice for future organ transplantation in humans for anatomical and physiological reasons. However, to bypass several immunological barriers, strong and stable human genes expression must occur in the pig's organs. In this study we created transgenic pigs using in vitro trans... | 18,823,265 |
Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines. | The canonical Wnt signalling pathway acts by slowing the rate of ubiquitin-mediated beta-catenin degradation. This results in the accumulation and subsequent nuclear translocation of beta-catenin, which induces the expression of a number of genes involved in growth, differentiation and metabolism. The mechanisms regula... | 18,823,284 |
Effect of a kappa-opioid agonist, i.v. JNJ-38488502, on sensation of colonic distensions in healthy male volunteers. | Kappa-opioid receptors are located on visceral pain fibres. JNJ-38488502 is a highly selective tetrapeptide kappa-opioid agonist with little access to the central nervous system and low risk of central nervous system side effects. The aim of the study was to evaluate the effects of i.v. JNJ-38488502 on sensations, incl... | 18,823,290 |
Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia. | To investigate the population pharmacokinetics of 6-mercaptopurine (6-MP) active metabolites in paediatric patients with acute lymphoblastic leukaemia (ALL) and examine the effects of various genetic polymorphisms on the disposition of these metabolites. Data were collected prospectively from 19 paediatric patients wit... | 18,823,306 |
The PDE5 inhibitor sildenafil increases circulating endothelial progenitor cells and CXCR4 expression. | Endothelial progenitor cells (EPC) are a specific subtype of progenitor cells that can be isolated from circulating mononuclear cells, able to migrate from the bone marrow to the peripheral circulation where they contribute to vascular repair. CXC-motif chemochine receptor 4 (CXCR4) receptor seems to play a critical ro... | 18,823,318 |
Activation of the ET-1/ETA pathway contributes to erectile dysfunction associated with mineralocorticoid hypertension. | The cavernosal tissue is highly responsive to endothelin-1 (ET-1), and penile smooth muscle cells not only respond to but also synthesize ET-1. Considering that ET-1 is directly involved in end-organ damage in salt-sensitive forms of hypertension, we hypothesized that activation of the ET-1/ET(A) receptor pathway contr... | 18,823,320 |
Escherichia coli tRNase Z can shut down growth probably by removing amino acids from aminoacyl-tRNAs. | In most organisms, tRNase Z is considered to be essential for 3' processing of tRNA molecules. The Escherichia coli tRNase Z gene, however, appears to be dispensable under normal growth conditions, and its existence remained an enigma. Here we intensively examined various (pre-)tRNAs for good substrates of E. coli tRNa... | 18,823,332 |
Indoor air disinfection using a polyester supported TiO2 photo-reactor. | Among the decontamination methods applicable to indoor air, heterogeneous photocatalysis has received increasing attention in recent years. This decontamination method is based on the UV irradiation of a solid catalyst, normally TiO2, aiming at the generation of highly reactive hydroxyl radicals. In this work, a novel ... | 18,823,342 |
Mannose-binding lectin gene polymorphisms in relation to periodontitis. | To investigate the correlation of six functional polymorphisms in the MBL gene with MBL plasma levels in relation to periodontitis. A total of 92 periodontitis patients and 70 controls, all of Caucasian origin, were included. Patients and controls were genotyped for the L/H, X/Y, P/Q, A/D, A/B and A/C polymorphisms. Di... | 18,823,346 |
Gender differences in the association of overweight and asthma morbidity among urban adolescents with asthma. | Asthma and obesity disproportionately affect US African-American youth. Among youth with asthma, obesity has been associated with poor control. The impact of gender on this association is unclear. We examined these relationships in a sample of urban, African-American adolescents with asthma. Questionnaires were used to... | 18,823,359 |
Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice. | Acute administration of repeated doses of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) dramatically reduces striatal dopamine (DA) content, tyrosine hydroxylase (TH), and DA transporter-immunoreactivity in mice. In this study, we show for the first time the spatiotemporal pattern of dopaminergic damage and related... | 18,823,368 |
Dopaminergic system dysregulation in the mrsk2_KO mouse, an animal model of the Coffin-Lowry syndrome. | The Coffin-Lowry syndrome, a rare syndromic form of X-linked mental retardation, is caused by loss-of-function mutations in the hRSK2 (RPS6KA3) gene. To further investigate RSK2 (90-kDa ribosomal S6 kinase) implication in cognitive processes, a mrsk2_KO mouse has previously been generated as an animal model of Coffin-L... | 18,823,370 |
Enhancement of apoptotic damage of squamous cell carcinoma cells by inhibition of the mitochondrial DNA repairing system. | Mitochondrial DNA (mtDNA) repair systems are thought to be associated with the susceptibility of cancer cells to anticancer agents. The present study investigated the relationship between the susceptibility to gamma-rays and the mtDNA repair ability of oral squamous cell carcinoma (OSC) cell lines. The levels of 8-hydr... | 18,823,381 |
Leishmania donovani depletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growth. | Intracellular pathogens employ several strategies for iron acquisition from host macrophages for survival and growth, whereas macrophage resists infection by actively sequestering iron. Here, we show that instead of allowing macrophage to sequester iron, protozoan parasite Leishmania donovani (LD) uses a novel strategy... | 18,823,384 |
The classification and diagnosis of erythrocytosis. | An absolute erythrocytosis is present when the red cell mass is raised and the haematocrit is elevated above prescribed limits. Causes of an absolute erythrocytosis can be primary where there is an intrinsic problem in the bone marrow and secondary where there an event outside the bone marrow driving erythropoiesis. Th... | 18,823,397 |
Introduction to hydromechanical well tests in fractured rock aquifers. | This article introduces hydromechanical well tests as a viable field method for characterizing fractured rock aquifers. These tests involve measuring and analyzing small displacements along with pressure transients. Recent developments in equipment and analyses have simplified hydromechanical well tests, and this artic... | 18,823,402 |
Transverse patterning dissociates human EEG theta power and hippocampal BOLD activation. | Theta oscillations (4-8 Hz) are often modulated in human electroencephalogram (EEG) studies of memory, whereas overlapping frequencies dominate rodent hippocampal EEG. An emerging parallelism between theta reactivity and hippocampal functional magnetic resonance imaging activation has suggested a homology between theta... | 18,823,411 |
Cardiovascular dynamics in blood phobia: evidence for a key role of sympathetic activity in vulnerability to syncope. | This study was aimed at clarifying the mechanism predisposing people with blood phobia to syncope by investigating the complete hemodynamic response pattern and the underlying autonomic control. Blood phobics and controls were shown 3 film-clips: phobia-related, phobia-unrelated, and neutral. Hemodynamic responses were... | 18,823,415 |
Perceiving age and gender in unfamiliar faces: brain potential evidence for implicit and explicit person categorization. | We used repetition priming to investigate implicit and explicit processes of unfamiliar face categorization. During prime and test phases, participants categorized unfamiliar faces according to either age or gender. Faces presented at test were either new or primed in a task-congruent (same task during priming and test... | 18,823,419 |
L-Ornithine-l-aspartate in the management of hepatic encephalopathy: a meta-analysis. | Hepatic encephalopathy continues to be a major clinical problem and the current decade has not witnessed major therapeutic breakthroughs in this area. L-ornithine-l-aspartate (LOLA) is not frequently used as there are still some reservations about its benefits. The present study aimed to assess the effectiveness and sa... | 18,823,442 |
Genetically engineered rice containing larger amounts of nicotianamine to enhance the antihypertensive effect. | Nicotianamine (NA), a metal chelator ubiquitous in higher plants, serves as an antihypertensive substance in humans. To engineer a novel antihypertensive rice that contains larger amounts of NA, the barley NA synthase gene, HvNAS1, was introduced into rice via Agrobacterium-mediated transformation. The introduced HvNAS... | 18,823,453 |
Meta-analysis of the diagnostic accuracy of transesophageal echocardiography for assessment of atherosclerosis in the ascending aorta in patients undergoing cardiac surgery. | Stroke after cardiac surgery may be caused by emboli emerging from an atherosclerotic ascending aorta (AA). Epiaortic ultrasound scanning (EUS), the current 'gold' standard for detecting AA atherosclerosis, has not gained widespread use because there is a lack of optimized ultrasound devices, it lengthens the procedure... | 18,823,455 |
Early time course of altered leukocyte response to lipopolysaccharide and peptidoglycan in porcine gunshot injury. | Penetrating injuries are frequently combined with polybacterial soiling. Clearance of the microorganisms depends on the ability to activate immune responses, but post-traumatic hyporeactivity of immune cells is almost universal. The aim of this study was to map the early time course of this altered leukocyte reactivity... | 18,823,462 |
Silence of ClC-3 chloride channel inhibits cell proliferation and the cell cycle via G/S phase arrest in rat basilar arterial smooth muscle cells. | Previously, we have found that the ClC-3 chloride channel is involved in endothelin-1 (ET-1)-induced rat aortic smooth muscle cell proliferation. The present study was to investigate the role of ClC-3 in cell cycle progression/distribution and the underlying mechanisms of proliferation. Small interference RNA (siRNA) i... | 18,823,498 |
Ventilation/Perfusion SPECT for diagnostics of pulmonary embolism in clinical practice. | The aim of this retrospective study is to illustrate clinical utility and impact of pulmonary embolism (PE) diagnostics of up to date Ventilation/Perfusion SPECT (V/P (SPECT)) applying holistic interpretation criteria. During a 2-year period 2328 consecutive patients referred to V/P(SPECT) for clinically suspected PE w... | 18,823,506 |
Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer. | The amplification event occurring at chromosome locus 11q13, reported in several different cancers, includes a number of potential oncogenes. We have previously reported amplification of one such oncogene, namely CCND1, to be correlated with an adverse effect of tamoxifen in premenopausal breast cancer patients. Over-e... | 18,823,530 |
Human embryonic stem cell research, justice, and the problem of unequal biological access. | In 2003, Ruth Faden and eighteen other colleagues argued that a "problem of unequal biological access" is likely to arise in access to therapies resulting from human embryonic stem cell research. They showed that unless deliberate steps are taken in the United States to ensure that the human embryonic stem cell lines a... | 18,823,539 |
Prevalence and determinants of child maltreatment among high school students in Southern China: a large scale school based survey. | Child maltreatment can cause significant physical and psychological problems. The present study aimed to investigate the prevalence and determinants of child maltreatment in Guangzhou, China, where such issues are often considered a taboo subject. A school-based survey was conducted in southern China in 2005. 24 high s... | 18,823,544 |
Tissue proteomics for cancer biomarker development: laser microdissection and 2D-DIGE. | Novel cancer biomarkers are required to achieve early diagnosis and optimized therapy for individual patients. Cancer is a disease of the genome, and tumor tissues are a rich source of cancer biomarkers as they contain the functional translation of the genome, namely the proteome. Investigation of the tumor tissue prot... | 18,823,585 |
Acrolein, the toxic endogenous aldehyde, induces neurofilament-L aggregation. | Acrolein is a highly reactive by product of lipid peroxidation and individuals with neurodegenerative disorders have been shown to contain elevated concentrations of this molecule in the brain. In the present study, we examined the pattern of neurofilament-L (NF-L) modification elicited by acrolein. When NF-L was incub... | 18,823,586 |
Taurine protects the antioxidant defense system in the erythrocytes of cadmium treated mice. | The present study was undertaken to investigate the protective role of taurine (2-aminoethanesulfonic acid) against cadmium (Cd) induced oxidative stress in murine erythrocytes. Cadmium chloride (CdCl(2)) was chosen as the source of Cd. Experimental animals were treated with either CdCl(2) alone or taurine, followed by... | 18,823,590 |
Preferential recognition of peroxynitrite modified human DNA by circulating autoantibodies in cancer patients. | Peroxynitrite (ONOO(-)) has been vastly implicated in mutagenesis and cancer development. Present study probes the antigenicity of peroxynitrite damaged DNA (ONOO(-)-DNA) in cancer patients. Purified human placental DNA was damaged by the synergistic action of sodium nitroprusside (SNP) and Pyrogallol for 3h at 37 degr... | 18,823,620 |
A quantitative method for representing balance strategies of goal-directed human motions. | A movement index termed balance strategy vector (BSV) was developed as a research tool for studying human balance strategies during goal-directed motions. For a given motion (motion capture data), the BSV index quantitatively represents its balance strategy by computing how available body joint DoFs' angular motions af... | 18,823,622 |
Removal of ammonia from contaminated air in a biotrickling filter - denitrifying bioreactor combination system. | The removal of gaseous ammonia in a system consisting of a biotrickling filter, a denitrification reactor and a polishing bioreactor for the trickling liquid was investigated. The system allowed sustained treatment of ammonia while preventing biological inhibition by accumulating nitrate and nitrite and avoiding genera... | 18,823,641 |
Methane oxidation in a boreal climate in an experimental landfill cover composed from mechanically-biologically treated waste. | The present study evaluated microbial methane (CH4) oxidation in a boreally located outdoor landfill lysimeter (volume 112 m3, height 3.9 m) filled with mechanically-biologically treated waste (MBT residual) and containing a cover layer made from the same MBT residual. The calculations based on gas emission and pore ga... | 18,823,644 |
Duration of anticoagulant therapy for patients with venous thromboembolism. | In principle, the answer to this question is obvious: "as long as the risk of continued therapy is outweighed by the benefit." In practice, determining an individual patient's risk of recurrent venous thromboembolism (VTE) without warfarin or other vitamin K antagonists is difficult. However, there are many factors (bo... | 18,823,648 |
Culture on electrospun polyurethane scaffolds decreases atrial natriuretic peptide expression by cardiomyocytes in vitro. | The function of the mammalian heart depends on the functional alignment of cardiomyocytes, and controlling cell alignment is an important consideration in biomaterial design for cardiac tissue engineering and research. The physical cues that guide functional cell alignment in vitro and the impact of substrate-imposed a... | 18,823,659 |
Demethylating agent 5-aza-2'-deoxycytidine activates HLA-G expression in human leukemia cell lines. | HLA-G is a non-classical HLA class I antigen primarily expressed in the extravillous cytotrophoblast. HLA-G can also be expressed at some pathological circumstances and may thus contribute to inhibition of efficient immune responses. Complex regulation of HLA-G expression also involves epigenetic mechanisms as DNA meth... | 18,823,661 |
Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial. | Diabetic retinopathy remains a leading cause of visual loss in people of working age. We examined whether candesartan treatment could slow the progression and, secondly, induce regression of retinopathy in people with type 2 diabetes. We did a randomised, double-blind, parallel-group, placebo-controlled trial in 309 ce... | 18,823,658 |
Enhanced short-term improvement of insulin response to a low-caloric diet in obese carriers the Gly482Ser variant of the PGC-1alpha gene. | The Gly482Ser missense mutation of the transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) has been involved in insulin function impairments, with conflicting results. The current study investigated the relationships of carrying this polymorphism with insulin re... | 18,823,672 |
Scope and design of the Following Rehabilitation, Economics and Everyday-Dialysis Outcome Measurements (FREEDOM) Study. | Conventional thrice-weekly hemodialysis (HD) has limited the ability to generate further improvements in patient quality of life, morbidity, and mortality. Daily HD (DHD) offers the promise of providing clinical and economic benefits. The objectives of the Following Rehabilitation, Economics and Everyday-Dialysis Outco... | 18,823,688 |
Approaches for the treatment of waste streams of the aluminium anodising industry. | The aluminium anodising industry is an important industrial sector that invariably generates great amounts of different waste streams. Classical and especially new-developing technologies dealing with them are reviewed. Innovative methods are mainly based on engineering geochemical processes, looking for the recovery o... | 18,823,703 |
Infections with weakly haemolytic Brachyspira species in pigs with miscellaneous chronic diseases. | The prevalence of infections with different Brachyspira species was assessed in 202 pigs with various chronic herd problems using different methods. Twenty-seven pigs (13.4%) were positive for Brachyspira spp. with at least one of the methods used. The highest number of positives was identified with mucosal scraping-PC... | 18,823,725 |
Cocaine-induced agitated delirium with associated hyperthermia: a case report. | "Cocaine-induced agitated delirium with associated hyperthermia" is a rare, almost uniformly fatal syndrome. The incidence of the disease is not known, however, it is believed to have markedly increased since the late 1980s with widespread popularity of crack cocaine. Recent literature is lacking regarding this rare sy... | 18,823,733 |
Metal-on-metal hip resurfacing: the effect of cup position and component size on range of motion to impingement. | The aim of this dry bone study was to determine the range of hip motion to impingement for different hip resurfacing cup positions and component sizes. The maximum angles of hip flexion, extension, abduction, and adduction were calculated from 3-dimensional coordinates for: 1. Cup inclination of 30 degrees , 40 degrees... | 18,823,742 |
Monte-Carlo simulations of elastically backscattered neutrons from hidden explosives using three different neutron sources. | Calculations of elastically backscattered (EBS) neutrons from hidden explosives buried in soil were performed using Monte-Carlo N-particle transport code MCNP5. Three different neutron sources were used in the study. The study re-examines the performance of the neutron backscattering methods in providing identification... | 18,823,788 |
Rupture of the left atrial 'basal' appendage due to blunt trauma in an elderly patient. | Blunt traumatic cardiac rupture is associated with a high mortality rate. Motor vehicle accidents account for most cardiac ruptures, but crush injury is relatively rare. We describe a case of a 77-year-old man who had the left atrial 'basal' appendage ruptured through blunt trauma due to a fall. He was surgically treat... | 18,823,789 |
Ultrasound of the peripheral nerves. | Peripheral nerves disorders are common in the rheumatologic practice and can mimic a variety of musculoskeletal diseases. Clinical evaluation remains the mainstay for diagnosing nerve disorders of the extremities. A careful history and an accurate physical examination lead in most patients to a high diagnostic suspicio... | 18,823,807 |
Development of working reference materials for clinical virology. | Nucleic acid amplification technique (NAT)-based assays are replacing traditional diagnostic methods in clinical laboratories. However, many of these assays are developed in-house and the lack of standardised reference materials has hindered assay implementation and control. Consequently, in the UK, the Clinical Virolo... | 18,823,817 |
Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer. | We previously identified a novel exogenous gammaretrovirus (xenotropic murine leukemia virus-related gammaretrovirus (XMRV)) using a pan-viral microarray. XMRV is the first MLV-related virus found in human infection. Forty percent (8/20) of familial prostate cancer patients homozygous for a mutation in RNase L (R462Q) ... | 18,823,818 |
Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence. | Comparing prefrontal cortical activity during particular phases of working memory in healthy subjects and individuals diagnosed with schizophrenia might help to define the phase-specific deficits in cortical function that contribute to cognitive impairments associated with schizophrenia. This study featured a spatial w... | 18,823,880 |
The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease. | Increased oxidative stress (SOX), inflammation and prevalence of cardiovascular disease (CVD) have been reported in end-stage renal disease (ESRD), but their associations with kynurenine (KYN) pathway activation remain unknown. We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HKY... | 18,823,890 |
Preparation of a sulfoxide group and ammonium-salt bonded silica stationary phase for separation of polychlorinated biphenyls from mineral oils. | In this study, a silica stationary phase modified with sulfoxide group and ammonium-salt was prepared for the separation of polychlorinated biphenyls (PCBs) from mineral oils, and its properties were investigated. Organic sulfide was attached to a diamino (primary and secondary amino) bonded silica surface by an amide ... | 18,823,892 |
Parental assessments of internalizing and externalizing behavior and executive function in children with primary hypertension. | To determine the relations between hypertension and parental ratings of behavior and executive functions in children with primary hypertension and to examine the potential moderating influence of obesity. Hypertensive and normotensive control groups were matched for age, sex, race, intelligence quotient, maternal educa... | 18,823,913 |
Advanced post-processing for scanned ultrasonic arrays: application to defect detection and classification in non-destructive evaluation. | This paper describes a number of array post-processing methods developed for scanning applications in non-destructive evaluation. The approach is to capture and process the full matrix of all transmit-receive time-domain signals from the array. Post-processing the data in this way enables a multitude of imaging modalit... | 18,823,924 |
Advanced treatment of the reverse osmosis concentrate produced during reclamation of municipal wastewater. | The work investigated the treatment of the concentrate produced from the reverse osmosis treatment of an MBR effluent. Two conventional chemical processes, coagulation and activated carbon adsorption, and three advanced oxidation processes (electrochemical treatment, photocatalysis and sonolysis) were applied. Coagulat... | 18,823,926 |
Role of integrin-linked kinase for functional capacity of endothelial progenitor cells in patients with stable coronary artery disease. | Number and function of endothelial progenitor cells (EPCs) are down-regulated in patients with coronary artery disease (CAD). Integrin-linked kinase (ILK) is a signal and adaptor protein that regulates survival of mature endothelial cells and vascular development. Here we show that EPC dysfunction in patients with CAD ... | 18,823,942 |
Differential effects of glutamate transporter inhibitors on the global electrophysiological response of astrocytes to neuronal stimulation. | Astrocytes are responsible for regulating extracellular levels of glutamate and potassium during neuronal activity. Glutamate clearance is handled by glutamate transporter subtypes glutamate transporter 1 and glutamate-aspartate transporter in astrocytes. DL-threo-beta-benzyloxyaspartate (TBOA) and dihydrokainate (DHK)... | 18,823,961 |
Use of ProteinChip technology for identifying biomarkers of parasitic diseases: the example of porcine cysticercosis (Taenia solium). | Taenia solium cysticercosis is a significant public health problem in endemic countries. The current serodiagnostic techniques are not able to differentiate between infections with viable cysts and infections with degenerated cysts. The objectives of this study were to identify specific novel biomarkers of these differ... | 18,823,977 |
Trypanosoma cruzi: Induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection. | Through a continuous in vivo drug pressure protocol, using mice as experimental model, we induced benznidazole resistance in Trypanosoma cruzi stocks. Full resistance was obtained for four out of five T. cruzi stocks analyzed. However, the number of benznidazole doses (40-180), as well as the time (4-18 months) necessa... | 18,823,980 |
Meta-analysis of the placebo rates of clinical relapse and severe endoscopic recurrence in postoperative Crohn's disease. | The benefit of therapy for prevention of postoperative recurrence of Crohn's disease (CD) is limited. Clinical relapse and severe endoscopic recurrence are the main outcomes in the evaluation of trials on prevention of recurrence. The aim of this meta-analysis was to focus on knowledge of the placebo rates of relapse a... | 18,823,987 |
Several major antiepileptic drugs are substrates for human P-glycoprotein. | One of the current hypotheses of pharmacoresistant epilepsy proposes that transport of antiepileptic drugs (AEDs) by drug efflux transporters such as P-glycoprotein (Pgp) at the blood-brain barrier may play a significant role in pharmacoresistance in epilepsy by extruding AEDs from their intended site of action. Howeve... | 18,824,002 |
Regulation of cytochrome P4501A1 expression by hyperoxia in human lung cell lines: Implications for hyperoxic lung injury. | Supplemental oxygen, used to treat pulmonary insufficiency in newborns, contributes to the development of bronchopulmonary dysplasia (BPD). Cytochrome P4501A enzymes are induced by hyperoxia in animal models, but their role in human systems is unknown. Here we investigated the molecular mechanisms of induction of CYP1A... | 18,824,009 |
Expression profiles of cloned channel catfish (Ictalurus punctatus) lymphoid cell lines and mixed lymphocyte cultures. | Clonal channel catfish lymphoid cell lines and mixed lymphocyte cultures (MLCs) have proven extremely useful in examining immune responses at the cellular and molecular levels. To date clonal catfish cell lines and MLCs have been biologically and phenotypically characterized using a variety of techniques including reve... | 18,824,023 |
Proteomic analysis of curdlan-producing Agrobacterium sp. in response to pH downshift. | During batch cultivation of Agrobacterium sp. ATCC 31750, proteome analysis in response to a pH downshift from 7.0 to 5.5 was carried out using two-dimensional electrophoresis and matrix-assisted laser desorption-ionization-time of flight mass spectrometry. When the pH of the exponentially growing Agrobacterium sp. cul... | 18,824,044 |
Does vivid emotional imagery depend on body signals? | The recall and re-experiencing of a personal emotional event (emotional imagery) are thought to evoke neural activity in the central nervous system that can affect the physiology of bodily states. It has been proposed that the more active the neural systems previously engaged in the emotional experience, and the more a... | 18,824,045 |
Analysis of cyanogens with resorcinol and picrate. | The total cyanogenic potential of various substrates (flax seed, stones of peach, plum, nectarine and apricot as well as apple seeds, and various model compounds) was investigated by using the acid hydrolysis method, picrate method, and a novel method based on the reaction of cyanide liberated from plants with resorcin... | 18,824,068 |
A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression. | The active form of vitamin D (1alpha,25(OH)(2)D(3)) is known to have antiproliferative effects and has been implicated in cancers of the colon, breast, and prostate. These cancers occur more frequently among African Americans than Caucasians, and individuals with African ancestry are known to have approximately twofold... | 18,824,104 |
CB(1) receptor antagonism: biological basis for metabolic effects. | The endocannabinoid system (ECS) is a complex physiologic system that affects metabolic pathways. A dysregulated ECS has been demonstrated in animal models of obesity and the expression of the cannabinoid type 1 (CB(1)) receptor in both brain and peripheral tissues suggests that selective antagonism at this receptor co... | 18,824,122 |
Targeting virulence traits: potential strategies to combat extraintestinal pathogenic E. coli infections. | Extraintestinal pathogenic Escherichia coli (ExPEC) are able to colonize, invade and induce disease in body niches outside the gastrointestinal tract. The emergence of (multi)resistant ExPEC variants calls for alternative antimicrobial strategies with a reduced pressure on selection of antibiotic resistances. We report... | 18,824,126 |
Small-molecule catalysts of oxidative protein folding. | Oxidative protein folding occurs both in vivo and in vitro and involves the formation and rearrangement of protein disulfide bonds (SS bonds). In vivo these reactions are catalyzed by enzymes, including the eukaryotic enzyme protein disulfide isomerase (PDI). Using the physical properties of PDI as a guide, several sma... | 18,824,127 |
Long-term effects of candesartan and amlodipine on cardiovascular mortality and morbidity in Japanese high-risk hypertensive patients: rationale, design, and characteristics of candesartan antihypertensive survival evaluation in Japan extension (CASE-J Ex). | Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial was conducted to compare the effects of the angiotensin II receptor blocker (ARB) candesartan and the calcium channel blocker (CCB) amlodipine on the incidence of cardiovascular (CV) events in Japanese high-risk hypertensive patients. After 3.2yea... | 18,824,134 |
Clinical correlations of human cytomegalovirus strains and viral load in kidney transplant recipients. | Little is known about clinical differences associated with cytomegalovirus (CMV) infection by distinct strains in renal transplant patients. Different clinical pictures may be associated with specific viral genotypes, viral load, as well as host factors. The objective of this study was to identify CMV strains to determ... | 18,824,137 |
Rat visceral yolk sac (VYS) and placenta mitochondrial features during the placentation period. | The transference of the nutritional function from the VYS to the chorioallantoic placenta during middle pregnancy is a key event for the activation of embryo oxidative metabolism. However, the metabolic adaptations occurring in these tissues during this critical period have not been studied to date. Herein, we investig... | 18,824,141 |
Integrated farming: why organic farmers should use transgenic crops. | The concept of organic farming is summarised and compared as an example to farming with biotechnology-derived crops. If done within an ecological concept, both methods can be seen as environmentally acceptable. Organic farming does not offer consistent arguments for the rejection of transgenic crops. Some arguments (fr... | 18,824,150 |
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