title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
|---|---|---|
Developmental coordination disorder in "apparently normal" schoolchildren born extremely preterm. | To determine the prevalence of developmental coordination disorder (DCD) in "apparently normal" extremely premature (<29 weeks) or extremely low birthweight (<1000 g) schoolchildren at 8 years of age and whether motor skill assessments at an earlier age could predict DCD. From a neonatal intensive care unit cohor... | 18,838,419 |
Saturation mutagenesis reveals that GLU54 of norovirus 3C-like protease is not essential for the proteolytic activity. | The norovirus 3C-like protease is a member of the chymotrypsin-like serine protease superfamily. Previous characterization of its crystal structure has implicated the Glu54-His30-Cys139 triad in the catalysis. In the present study, the Glu54 residue of the protease was subjected to site-saturation mutagenesis, with the... | 18,838,436 |
Early individualised parenteral nutrition for preterm infants. | Considerable effort should be made to optimise parenteral nutrition of preterm infants in order to limit the development of postnatal growth restriction. A monocentric before-and-after study design was used to determine the effects of computerising parenteral nutrition ordering on the composition of parenteral nutritio... | 18,838,470 |
Oesophageal and gastric intestinal-type adenocarcinomas show the same male predominance due to a 17 year delayed development in females. | Upper gastrointestinal adenocarcinomas show an unexplained male predominance that is more apparent in oesophagus than stomach and in intestinal than diffuse histological subtype. We have conducted a population-based study to determine whether the gender phenomenon is primarily related to the anatomical site or the hist... | 18,838,486 |
Tolerance to the cataleptic effect that follows repeated nitric oxide synthase inhibition may be related to functional enzymatic recovery. | Systemic or intra-striatal acute administration of nitric oxide synthase (NOS) inhibitors causes catalepsy in rodents. This effect disappears after sub-chronic treatment. The aim of the present study was to investigate if this tolerance is related to changes in the expression of NOS or dopamine-2 (D2) receptor or to a ... | 18,838,497 |
Expression and functional analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 isozymes. | The objectives of this study were to compare the drug-metabolizing activity of human CYP2D6.24 (I297L), CYP2D6.26 (I369T), and CYP2D6.27 (E410K) allelic isoforms with wild-type CYP2D6.1 and to express the CYP2D7 protein derived from an indel polymorphism (CYP2D7 138delT) and investigate its possible codeine O-demethyla... | 18,838,503 |
Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels. | Homocysteinemia is associated with elevated oxidative stress and impaired endothelial function. In the present study we examined the impact of oxidative stress in the development of endothelial dysfunction in both chronic and acute (methionine-induced) homocysteinemia in humans. We also examined the role of endothelin-... | 18,838,525 |
Food consumption and the risk of type 1 diabetes in children and youth: a population-based, case-control study in Prince Edward Island, Canada. | The objective of this study was to determine if the consumption of certain foods during the year prior to diagnosis of type 1 diabetes mellitus (T1D) was associated with the risk of developing T1D in children and youth residing in Prince Edward Island, Canada. Cases (n = 57) consisted of newly diagnosed patients with T... | 18,838,530 |
Vitamin B6 is associated with depressive symptomatology in Massachusetts elders. | We examined the cross-sectional relationship between dietary vitamin B6 and plasma pyridoxyl-5'-phosphate concentrations (PLP) with depressive symptomatology among a representative sample of 618 elderly Caribbean Hispanics, and a neighborhood based comparison group of 251 non-Hispanic white (NHW) older adults in Massac... | 18,838,531 |
Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles. | Aberrant glycogen synthase kinase 3beta (GSK-3beta) activity is associated with the progression of several pathological conditions such as diabetes, Alzheimer's, and cancer. GSK-3beta regulates cellular processes by directly phosphorylating metabolic enzymes and transcription factors. Here, we discovered a new target f... | 18,838,540 |
The keratin-binding protein Albatross regulates polarization of epithelial cells. | The keratin intermediate filament network is abundant in epithelial cells, but its function in the establishment and maintenance of cell polarity is unclear. Here, we show that Albatross complexes with Par3 to regulate formation of the apical junctional complex (AJC) and maintain lateral membrane identity. In nonpolari... | 18,838,552 |
The test validation summary. | Common rates employed in classificatory testing are the true positive rate (TPR), false positive rate (FPR), positive predictive power (PPP), and negative predictive power (NPP). FPR and TPR are estimated from research samples representing populations to be distinguished by classificatory testing. PPP and NPP are used ... | 18,838,580 |
Development of an optimized dose for coformulation of zidovudine with drugs that select for the K65R mutation using a population pharmacokinetic and enzyme kinetic simulation model. | In vitro selection studies and data from large genotype databases from clinical studies have demonstrated that tenofovir disoproxil fumarate and abacavir sulfate select for the K65R mutation in the human immunodeficiency virus type 1 polymerase region. Furthermore, other novel non-thymine nucleoside reverse transcripta... | 18,838,591 |
Cost and cost-effectiveness of the COMBINE study in alcohol-dependent patients. | The COMBINE (Combined Pharmacotherapies and Behavioral Intervention) clinical trial recently evaluated the efficacy of medications, behavioral therapies, and their combinations for the outpatient treatment of alcohol dependence. The costs and cost-effectiveness of these combinations are unknown and of interest to clini... | 18,838,638 |
Missed diagnosis of critical congenital heart disease. | To evaluate the rate and the clinical and demographic characteristics of missed diagnosis of critical congenital heart disease (CCHD). Population-based retrospective study of 1989-2004 California statewide death registry data. California. The study cohort consisted of 898 infants who died of CCHD at 1 to 364 days of ag... | 18,838,650 |
Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. | We directly sequenced cell-free DNA with high-throughput shotgun sequencing technology from plasma of pregnant women, obtaining, on average, 5 million sequence tags per patient sample. This enabled us to measure the over- and underrepresentation of chromosomes from an aneuploid fetus. The sequencing approach is polymor... | 18,838,674 |
Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. | Cytochrome P450(BioI) (CYP107H1) from the biotin operon of Bacillus subtilis forms a seven-carbon diacid through a multistep oxidative cleavage of a fatty acid linked to acyl carrier protein (ACP). Crystal structures of P450(BioI) in complex with three different length fatty acyl-ACP (Escherichia coli) ligands show tha... | 18,838,690 |
Aptamer-based endocytosis of a lysosomal enzyme. | Enzyme replacement therapy for lysosomal storage diseases is currently based on endocytosis of lysosomal enzymes via the mannose or mannose 6-phosphate receptors. We are developing a technology for endocytosis of lysosomal enzymes that depends on generic, chemically conjugated reagents. These reagents are aptamers (sin... | 18,838,694 |
Clinical manifestations and antiretroviral management of HIV/AIDS patients with tuberculosis co-infection in Kramat 128 Hospital. | to give a description of HIV-AIDS and tuberculosis co-infection in Jakarta, viewed from the perspective of virologic and immunologic status and the correct selection of antiretrovirals. cross-sectional descriptive study was performed on the outpatient clinic of Kramat 128, from June to July 2007. Tuberculosis infection... | 18,838,749 |
The new three-dimensional supramolecule bis{mu-2-[(4-hydroxybenzoyl)hydrazonomethyl]phenolato}bis[aquacopper(II)] dinitrate. | In the title centrosymmetric binuclear complex, [Cu(2)(C(14)H(11)N(2)O(3))(2)(H(2)O)(2)](NO(3))(2), the two metal centres are bridged by the phenolate O atoms of the ligand, forming a Cu(2)O(2) quadrangle. Each Cu atom has a distorted square-pyramidal geometry, with the basal donor atoms coming from the O,N,O'-tridenta... | 18,838,761 |
Electrophysiological properties of NtTPK1 expressed in yeast tonoplast. | The patch clamp technique using enlarged yeast tonoplasts is an effective approach to characterizing the Nicotiana tabacum plant tonoplast K+ channel, NtTPK1. We report here that the NtTPK1-mediated currents comprise two phase components, both which were found to be highly selective for K+ over Na+ and Cl-. | 18,838,784 |
Improved solubilization of recombinant human growth hormone inclusion body produced in Escherichia coli. | Recombinant human growth hormone (r-hGH) overexpressed in Escherichia coli forms inactive and insoluble aggregates as inclusion bodies in the cytoplasm. The efficient solubilization of inclusion bodies is critical for cost-effective production. Contrary to a previous report, in our production system, the solubilization... | 18,838,803 |
Exploring the biosynthesis of natural products and their inherent suitability for the rational design of desirable compounds through genetic engineering. | Much effort has been invested in studying how natural products are biosynthesized, and great advances have been made in understanding how these compounds acquire their structural complexity and biological activities. In recent years, significant progress has been made due to the devoted efforts of scientists in this fi... | 18,838,806 |
Depigmenting mechanisms of all-trans retinoic acid and retinol on B16 melanoma cells. | We assessed the effects of ATRA and retinol on melanogenesis in murine B16 melanoma cells. In the present study, ATRA and retinol inhibited melanin synthesis in melanoma cells stimulated by alpha-melanocyte stimulating hormone (alpha-MSH) or 3-isobutyl-1-methylxanthine (IBMX). To elucidate the target points of ATRA and... | 18,838,813 |
Absorption, migration and kinetics in peripheral blood of orally administered ovalbumin in a mouse model. | Intestinal absorption of food proteins is well known, whereas its physiological significance remains to be investigated. Various amounts (1, 10 and 50 mg) of ovalbumin were orally administered to mice and the blood kinetics were subsequently analyzed by two-site ELISA. The blood ovalbumin concentration consistently rea... | 18,838,817 |
The metabolism and distribution of docosapentaenoic acid (n-6) in the liver and testis of growing rats. | To investigate the metabolism and distribution of docosapentaenoic acid (22:5n-6, DPA) in the liver and testis of growing rats, 22:5n-6 was administered to their dams. Newborn rats with a low hepatic arachidonic acid (20:4n-6, AA) level were generated by administrating a diet rich in docosahexaenoic acid (22:6n-3, DHA)... | 18,838,818 |
Preventive effect of Streptococcus thermophilus YIT 2001 on dextran sulfate sodium-induced colitis in mice. | We investigated the preventive effect of Streptococcus thermophilus YIT 2001, a lactic acid bacterum having high antioxidative activity, on acute colitis induced by 2.5% dextran sulfate sodium in mice, and compared the effect with that of S. thermophilus YIT 2084 which has lower antioxidative activity. Feeding S. therm... | 18,838,819 |
Improvement of L-lysine production by Methylophilus methylotrophus from methanol via the Entner-Doudoroff pathway, originating in Escherichia coli. | To improve the amino acid production by metabolic engineering, eliminating the pathway bottleneck is known to be very effective. The metabolic response of Methylophilus methylotrophus upon the addition of glucose and of pyruvate was investigated in batch cultivation. We found that the supply of pyruvate is a bottleneck... | 18,838,820 |
Biological activities of Korean Citrus obovoides and Citrus natsudaidai essential oils against acne-inducing bacteria. | This study was designed to analyze the chemical composition of Citrus obovoides (Geumgamja) and Citrus natsudaidai (Cheonyahagyul) oils and to test their biological activities. These citrus essential oils were obtained by steam distillation of fruits collected from Jeju Island, Korea, and were analyzed using gas chroma... | 18,838,824 |
Chemical composition and anti-inflammatory effects of essential oil from Farfugium japonicum flower. | In this study, the chemical composition and anti-inflammatory activities of hydrodistilled essential oil from Farfugium japonicum were investigated for the first time. The chemical constituents of the essential oil were further analyzed by GC-MS and included 1-undecene (22.43%), 1-nonene (19.83%), beta-caryophyllene (1... | 18,838,835 |
Accuracy of spring-levered and piezo-electric pedometers in primary school Japanese children. | Pedometers are used in many studies because physical activities can be simply assessed using them. In addition to the spring-levered type, piezo-electric pedometers have recently been used. However, their accuracy in children has not been investigated in previous studies. In this study, we investigated the accuracy of ... | 18,838,838 |
Ankle MRI for anterolateral soft tissue impingement: increased accuracy with the use of contrast-enhanced fat-suppressed 3D-FSPGR MRI. | To validate the use of contrast-enhanced (CE) fat-suppressed three-dimensional (3D) fast gradient-recalled acquisition in the steady state with radiofrequency spoiling (FSPGR) magnetic resonance imaging (MRI) for the diagnosis of anterolateral soft tissue impingement of the ankle, as compared to the use of routine ankl... | 18,838,849 |
CT images of a malignant-transformed ovarian mature cystic teratoma with rupture: a case report. | A malignant transformation or a tumor rupture is a rare complication of ovarian mature cystic teratoma (MCT). A tumor rupture in a malignant-transformed MCT has never been reported in the literature. We present the CT images of a 39-year-old woman showing a large, predominantly cystic mass in the lower abdomen, with fa... | 18,838,856 |
Microarray and pathway analysis reveals decreased CDC25A and increased CDC42 associated with slow growth of BCL2 overexpressing immortalized breast cell line. | Bcl-2 is an anti-apoptotic protein that is frequently overexpressed in cancer cells but its role in carcinogenesis is not clear. We are interested in how Bcl-2 expression affects non-cancerous breast cells and its role in the cell cycle. We prepared an MCF10A breast epithelial cell line that stably overexpressed Bcl-2.... | 18,838,868 |
Basics of particle therapy: introduction to hadrons. | With the arrival of 3-dimensional conformal radiation therapy and intensity modulated radiation therapy, radiation dose distributions in radiation oncology have improved dramatically over the past couple of decades. As part of a natural progression there recently has been a resurgence of interest in hadron therapy, spe... | 18,838,888 |
Guiding the clinical nurse through research publication development. | Clinical nurses conduct research as a component of their professional role. The final step of the research process is communicating findings to the nursing community. Some staff nurses may be reluctant to assume the role of first-time author because of a lack of understanding of the basic mechanics of manuscript develo... | 18,838,901 |
Community nurses who thrive: the critical role of job engagement in the face of adversity. | Among community health nurses who thrive despite difficult working circumstances, habitual introspection and reflection about job engagement helped them make positive, adaptive adjustments in their working life. A practical implication is the need to educate nurses about the importance of reflection not only over nursi... | 18,838,896 |
Podoplanin (D2-40) is a highly effective marker of follicular dendritic cells. | The monoclonal antibody D2-40 recognizes the membrane protein podoplanin, which is an established marker for germ cell tumors, mesotheliomas, and other tumor types and is also expressed in a variety of normal cells including follicular dendritic cells (FDCs). To determine whether podoplanin represents an effective FDC ... | 18,838,918 |
The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: a randomized, controlled open study. | Hypotonic fluids are widely used in pediatrics. Several articles have reported the risk of iatrogenic hyponatremia secondary to this practice. We primarily intend to determine whether the use of isotonic fluids prevents hyponatremia and, secondly, whether these fluids increase the incidence of adverse events. One hundr... | 18,838,929 |
Gas exchange and lung mechanics during high frequency ventilation in the perflubron-treated lung. | To identify the effect of perflubron on gas exchange and lung mechanics during high frequency oscillatory ventilation in an animal model. Prospective randomized animal trial. Eighteen Yorkshire swine. Three groups of six animals each were investigated: control (high frequency oscillatory ventilation alone), low dose pe... | 18,838,935 |
Molecular effects of exercise in patients with inflammatory rheumatic disease. | Exercise is now known to be beneficial for patients with inflammatory rheumatic disease. In patients with rheumatoid arthritis, exercise can improve physical performance, cardiorespiratory fitness and muscle strength, and reduce disease activity and systemic inflammation, as evidenced by reductions in erythrocyte sedim... | 18,839,010 |
GM-CSF deficiency delays neointima formation in a normolipidemic mouse model of endoluminal endothelial damage. | Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been implicated in atherogenesis and has been shown to have both pro- and antiatherogenic properties. Neointimal thickening is a prominent feature of early atherogenesis. This study aimed to examine the role of GM-CSF in neointimal formation induced by endot... | 18,839,015 |
Transurethral Resection of Bladder Tumor (TUR-BT) then Concomitant Radiation and Cisplatin Followed by Adjuvant Gemcitabine and Cisplatin in Muscle Invasive Transitional Cell Carcinoma (TCC) of the Urinary Bladder. | To evaluate the efficacy, safety, and tolerance of bladder preservation trimodality protocol combining maximal transurethral resection of bladder tumor (TURBT) with concomitant chemoradiation (CCRT) followed by adjuvant chemotherapy in patients with muscle invasive transitional cell carcinoma (TCC) of the bladder. Betw... | 18,839,038 |
Estimated drug overdose deaths averted by North America's first medically-supervised safer injection facility. | Illicit drug overdose remains a leading cause of premature mortality in urban settings worldwide. We sought to estimate the number of deaths potentially averted by the implementation of a medically supervised safer injection facility (SIF) in Vancouver, Canada. The number of potentially averted deaths was calculated us... | 18,839,040 |
Controlling firearms use in Australia: has the 1996 gun law reform produced the decrease in rates of suicide with this method? | Observed reductions in firearm suicides in Australia have been linked to the 1997 national firearms agreement (NFA) introduced following the 1996 Port Arthur massacre. The NFA placed strong access restrictions on firearms. To assess the impact of legislative restrictions on the incidence of firearm suicide in Queenslan... | 18,839,044 |
The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease. | Insulin resistance is a major feature of type 2 diabetes mellitus, obesity and nonalcoholic fatty liver disease (NAFLD). Several studies pointed out the possible role of increased leptin in NAFLD in humans. The aim of this study is to determine the effect of metformin on plasma leptin levels in obese patients with type... | 18,839,053 |
Unique microstructures and podocytic infolding in glomerular basement membrane associated with collagen diseases: a report of three cases. | Unique renal histopathological appearances, consisting of podocytic infolding and microstructures in the glomerular basement membrane (GBM) were identified in the renal biopsies from three patients with collagen diseases such as systemic lupus erythematosus (lupus nephritis, class II) and Sjögren's syndrome. In each ca... | 18,839,060 |
A case of systemic lupus erythematosus showing invagination of the podocyte into the glomerular basement membrane: an electron microscopic observation of a repeated-renal biopsy. | A case of systemic lupus erythematosus (SLE) showing invagination of glomerular epithelial cells into the glomerular basement membrane (GBM) has been reported. The patient was a 30-year-old woman who was diagnosed with SLE at the age of 25 and had been medicated with corticosteroid. At the age of 30, she was re-admitte... | 18,839,064 |
Two-photon imaging of capillary blood flow in olfactory bulb glomeruli. | Two-photon laser scanning microscopy (TPLSM) is an efficient tool to study cerebral blood flow (CBF) and cellular activity in depth in the brain. We describe here the advantages and weaknesses of the olfactory bulb as a model to study neurovascular coupling using TPLSM. By combining intra- and extracellular recordings,... | 18,839,088 |
Magnetoencephalography (MEG). | Magnetoencephalography (MEG) encompasses a family of non-contact, non-invasive techniques for detecting the magnetic field generated by the electrical activity of the brain, for analyzing this MEG signal and for using the results to study brain function. The overall purpose of MEG is to extract estimates of the spatiot... | 18,839,092 |
Real-time PCR analysis for blood cell lineage specific markers. | We here describe the methods for the isolation of distinct hematopoietic subpopulations, as defined by their immune phenotype by fluorescence-activated cell sorting, and how these cells can be analyzed even at a single-cell level for the gene expression of a number of transcription factors and other differentiation mar... | 18,839,120 |
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. | The role of drotrecogin alfa (activated) (DAA) in severe sepsis remains controversial and clinicians are unsure whether or not to treat their patients with DAA. In response to a request from the European Medicines Agency, Eli Lilly will sponsor a new placebo-controlled trial and history suggests the results will be sub... | 18,839,141 |
In vivo flexion and kinematics of the knee after TKA: comparison of a conventional and a high flexion cruciate-retaining TKA design. | This study investigated the in vivo 6DOF knee kinematics and tibiofemoral contact location after total knee arthroplasty using a conventional and a high flexion cruciate retaining component (15 NexGen CR, 11 NexGen CR-Flex). Each patient performed a single-leg lunge while being imaged by a dual fluoroscopic imaging sys... | 18,839,144 |
Comparison of ultrasound-, palpation-, and scintigraphy-guided steroid injections in the treatment of plantar fasciitis. | The aim of the study was to compare the efficacies of steroid injections guided by scintigraphy, ultrasonography, and palpation in plantar fasciitis. A total of 35 heels of 27 patients were randomly assigned to three steroid injection groups: palpation-guided (pg), ultrasound-guided (ug), and scintigraphy-guided (sg). ... | 18,839,190 |
Outcome of radiotherapy in T1 glottic carcinoma: a population-based study. | We evaluated the radiation outcome and prognostic factors in a population-based study of early (T1N0M0) glottic carcinoma. Survival parameters and prognostic factors were evaluated by uni- and multivariate analysis in 316 consecutive irradiated patients with T1 glottic carcinoma in the Comprehensive Cancer Center West ... | 18,839,197 |
The time course of presaccadic attention shifts. | The dynamics of the allocation of attention during the preparation of saccadic eye movements was studied in a dual task paradigm. As the primary task, participants had to perform a saccade to letter-like items arranged on a clock face. The secondary task was a 2AFC discrimination task in which a discrimination target (... | 18,839,208 |
Gastroenteropancreatic neuroendocrine tumors: indications for and pitfalls of frozen section examination. | Gastroenteropancreatic neuroendocrine tumors constitute a heterogeneous group of neoplasms. Surgical resection remains the only curative treatment. Frozen section examination is requested by the surgeon in a large variety of surgical situations, but its use differs greatly according to the location of the tumor and the... | 18,839,209 |
Tree diversity, composition, forest structure and aboveground biomass dynamics after single and repeated fire in a Bornean rain forest. | Forest fires remain a devastating phenomenon in the tropics that not only affect forest structure and biodiversity, but also contribute significantly to atmospheric CO2. Fire used to be extremely rare in tropical forests, leaving ample time for forests to regenerate to pre-fire conditions. In recent decades, however, t... | 18,839,212 |
Toward using delta13C of ecosystem respiration to monitor canopy physiology in complex terrain. | In 2005 and 2006, air samples were collected at the base of a Douglas-fir watershed to monitor seasonal changes in the delta13CO2 of ecosystem respiration (delta13C(ER)). The goals of this study were to determine whether variations in delta13C(ER) correlated with environmental variables and could be used to predict exp... | 18,839,214 |
Measuring glomerular filtration rate in children; can cystatin C replace established methods? A review. | Our aim was to evaluate published methods that use serum cystatin C (s-CysC) for measuring glomerular filtration rate (GFR) in children and to discuss advantages and limitations of s-CysC and of established GFR methods. A comprehensive literature review of clinical studies in children evaluating s-CysC or CysC-based fo... | 18,839,216 |
Reversal of hypercalcemic acute kidney injury by treatment with intravenous bisphosphonates. | We present the details of three children with hypercalcemia-induced acute kidney injury (AKI). After traditional therapy with fluids, loop diuretics, steroids and calcitonin had failed to correct the hypercalcemia, they were given treatment with low doses of intravenous (i.v.) pamidronate, which resulted in normalizati... | 18,839,218 |
Palonosetron (Aloxi) and dexamethasone for the prevention of acute and delayed nausea and vomiting in patients receiving multiple-day chemotherapy. | The objective of this study was to determine the efficacy of palonosetron combined with dexamethasone in prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) in patients receiving multiple-day chemotherapy and the efficacy of a second dose of palonosetron in treating breakthrough emesis. Fort... | 18,839,220 |
Posterior lumbar interbody fusion using rhBMP-2. | The use of biological technologies for the treatment of degenerative spinal diseases has undergone rapid clinical and scientific development. BMP strategies have gained wide support for an inherent potential to improve the ossification process. It has been extensively studied in combination with various techniques for ... | 18,839,225 |
Grading of degenerative disk disease and functional impairment: imaging versus patho-anatomical findings. | Degenerative instability affecting the functional spinal unit is discussed as a cause of symptoms. The value of imaging signs for assessing the resulting functional impairment is still unclear. To determine the relationship between slight degrees of degeneration and function, we performed a biomechanical study with 18 ... | 18,839,226 |
Assessing the effectiveness of a constructed Arctic stream using multiple biological attributes. | Objective assessment of habitat compensation is a central yet challenging issue for restoration ecologists. In 1997, a 3.4-km stream channel, designed to divert water around an open pit diamond mine, was excavated in the Barrenlands region of the Canadian Arctic to create productive stream habitat. We evaluated the ini... | 18,839,240 |
Biotransformation of 2,4,6-trinitrotoluene by pure culture ruminal bacteria. | Twenty-one ruminal bacteria species were tested for their ability to degrade 2,4,6-trinitrotoluene (TNT) within 24 h. Butyrivibrio fibrisolvens, Fibrobacter succinogenes, Lactobacillus vitulinus, Selenomonas ruminantium, Streptococcus caprinus, and Succinivibrio dextrinosolvens were able to completely degrade 100 mg/L ... | 18,839,246 |
Effects of fertilization and fungal and insect attack on systemic protein defenses of austrian pine. | Despite their economic and ecological importance, defense responses of conifers to pests are little understood. In a 3-year experiment, we monitored systemic fungal (Diplodia pinea)- and insect (Neodiprion sertifer)-induced defense protein activities and total soluble proteins in needles and phloem of Austrian pine (Pi... | 18,839,253 |
Identification of novel C(20) and C (22) trienoic acids from arctiid and geometrid female moths that produce polyenyl Type II Sex pheromone components. | Gas chromatography-mass spectrometry (GC-MS) and GC-electroantennographic detection (EAD) analyses of the sex pheromone extract from a wasp moth, Syntomoides imaon (Lepidoptera: Arctiidae: Syntominae), showed that virgin females produced (Z,Z,Z)-3,6,9-henicosatriene and (Z,Z,Z)-1,3,6,9-henicosatetraene with a trace amo... | 18,839,254 |
Spontaneous dissection of internal carotid artery masquerading as angioedema. | Spontaneous dissection of the internal carotid artery usually presents with stroke-like symptoms secondary to ischemia in its vascular territory, as well as local signs and symptoms, which may include head, face or neck pain, Horner's syndrome, pulsatile tinnitus, and cranial nerve palsies. We report a case of a 44-yea... | 18,839,259 |
Managing flexion knee deformity using a circular frame. | Knee flexion deformity can cause marked physical disability. Acute correction, whether nonoperative or operative, may lead to serious complications. We treated 50 patients (71 knees) between 1994 and 2002 with the Ilizarov external fixator. The deformity was gradually corrected using Ilizarov principles. Of the 50 pati... | 18,839,263 |
A case of ANCA-associated systemic vasculitis induced by atorvastatin. | We present a 45-year-old male patient who presented to Accident and Emergency department with a 6-week history of pain and stiffness involving his bilateral legs. Both calves were markedly tender, and he was not able to bear weight. He also complained of numbness involving his left big toe for a few days, which later s... | 18,839,266 |
Evaluation of groundwater resources in a tiny Andrott Island, Union Territory of Lakshadweep, India. | Lakshadweep is a group of 36 coral islands scattered in the Arabian Sea off the western coast of India. On such small tiny islands, groundwater is the only source of fresh water for the islanders. Due to the growing population on these islands, demand for fresh water is also increasing and on the other side the peculia... | 18,839,323 |
Resistin induces rat insulinoma cell RINm5F apoptosis. | Beta-cell apoptosis induced by adipokines may result in beta-cell dysfunction in type 2 diabetes. Resistin, an adipokine-linked obesity with type 2 diabetes, impairs glucose-stimulated insulin secretion (GSIS) in beta-cells. Presently, the effects of resistin on rat insulinoma cells RINm5F were examined. Treatment of R... | 18,839,335 |
RNA isolation from Xenopus inner ear sensory endorgans for transcriptional profiling and molecular cloning. | The amphibian Xenopus offers a unique model system for uncovering the genetic basis of auditory and vestibular function in an organism that is well-suited for experimental manipulation during animal development. However, many procedures for analyzing gene expression in the peripheral auditory and vestibular systems man... | 18,839,338 |
Personality and EQ-5D scores among individuals with chronic conditions. | Personality is associated with self-rated health, but prior studies have not examined associations with preference-based measures. We hypothesized similar associations would exist with preference-based health. We analyzed baseline data from chronically ill individuals enrolled in a self-management intervention. We cond... | 18,839,336 |
In vivo verification of protein interactions in the inner ear by coimmunoprecipitation. | Genomics has provided us with vast amounts of data and thus, the challenge to identify and characterize gene products. Proteomics analysis, using methods such as yeast two-hybrid screenings, isoelectric focusing, and mass spectroscopy, generate potentially useful information. To determine functional relationships betwe... | 18,839,355 |
Surface plasmon resonance (SPR) analysis of binding interactions of proteins in inner-ear sensory epithelia. | Surface plasmon resonance is an optical technique utilized for detecting molecular interactions. Binding of a mobile molecule (analyte) to a molecule immobilized on a thin metal film (ligand) changes the refractive index of the film. The angle of extinction of light, reflected after polarized light impinges upon the fi... | 18,839,357 |
The Norwegian Hip Fracture Register: experiences after the first 2 years and 15,576 reported operations. | The Norwegian Hip Fracture Register was established in January 2005 to collect nationwide information as a basis for improved management of patients with hip fractures. We now report our experience after the first 2 years. After both primary operations and reoperations, the surgeons fill in a standardized 1-page form w... | 18,839,363 |
Hand-made articulating spacers in two-stage revision for infected total knee arthroplasty: good outcome in 30 patients. | The most reliable results when treating an infected total knee arthroplasty have been obtained with a two-stage reimplantation protocol. We have used a simple technique for hand-made spacers and now report the outcome. 30 patients with an infected total knee arthroplasty (TKA) were treated with a 2- stage reimplantatio... | 18,839,375 |
Second-look microlaryngoscopy to detect residual carcinoma in patients after laser surgery for T1 and T2 laryngeal cancer. | The presented concept of second-look microlaryngoscopy in patients treated with transoral laser surgery (TLS) for early glottic carcinoma is promising and warrants further studies to evaluate its benefits. Clear surgical margins at the primary site influence the course of the disease in patients with laryngeal carcinom... | 18,839,386 |
Rheological properties of cross-linked hyaluronan-gelatin hydrogels for tissue engineering. | Hydrogels that mimic the natural extracellular matrix (ECM) are used in three-dimensional cell culture, cell therapy, and tissue engineering. A semi-synthetic ECM based on cross-linked hyaluronana offers experimental control of both composition and gel stiffness. The mechanical properties of the ECM in part determine t... | 18,839,402 |
Percutaneous ultrasound-guided stenting of the atrial septum in fetal sheep. | Hypoplastic left heart syndrome (HLHS) with a restricitive foramen ovale is associated with high mortality related to fetal left atrial hypertension. Fetal atrial balloon septoplasty has largely failed to achieve adequate decompression due to the small size of the holes produced. We attempted to produce larger atrial c... | 18,839,405 |
Trait anger and anger expression style in children's risky decisions. | In this study, 104 children completed a task, measuring risk decision-making, and the State-Trait Anger Expression Inventory for Children and Adolescents. Subjects were also asked to evaluate the degree of danger, benefit, fun and fear perceived for each risky choice. Analyses indicated that (a) risk decision-making wa... | 18,839,406 |
Midgut mitochondrial transhydrogenase in wandering stage larvae of the tobacco hornworm, Manduca sexta. | Midgut mitochondria from fifth larval instar Manduca sexta exhibited a transhydrogenase that catalyzes the following reversible reaction: NADPH + NAD(+) <--> NADP(+) + NADH. The NADPH-forming transhydrogenation occurred as a nonenergy- and energy-linked activity. Energy for the latter was derived from the electro... | 18,839,416 |
Co-prescribing azathiopurine or 6-mercaptopurine and 5-aminosalicylate compounds in ulcerative colitis. | A total of 254 senior consultant gastroenterologists with valid e-mail addresses were identified from the membership list of the British Society of Gastroenterology (BSG) 2007. They were sent by e-mail a questionnaire which dealt with aspects of clinical practice and addressed cancer prevention in ulcerative colitis (U... | 18,839,420 |
Gene expression profiles of mucosal fibroblasts from strictured and nonstrictured areas of patients with Crohn's disease. | A frequent complication of Crohn's disease (CD) is the formation of strictures and stenoses. Strictures are characterized by a fibrosis of the bowel wall, induced by abnormal wound healing. Functional changes of colonic lamina propria fibroblasts (CLPF) reflected by increased proliferation and collagen synthesis, incre... | 18,839,425 |
Association between plasma thiols and immune activation marker neopterin in stable coronary heart disease. | Studies have associated elevated plasma levels of the thiols homocysteine and cysteine with an increased risk of atherosclerosis. Their relationship with systemic inflammatory parameters and sclerosis scores was investigated in this study. Total homocysteine, total cysteine, neopterin and C-reactive protein (CRP) conce... | 18,839,466 |
The effect of the mode of delivery on the maternal-neonatal carnitine blood levels and antioxidant status. | Carnitine blood levels are closely related to beta-oxidation and implicated with strenuous muscle contractions. Normal delivery process is characterized by the participation of the uterus and most skeletal muscles. Women with normal pregnancy (n = 56) were divided into two groups. Group A (n = 26) with normal labor and... | 18,839,469 |
Time to reconsider the clinical value of immunoglobulin G4 to foods? | The usefulness of serum antibodies to common food antigens (immunoglobulin G4; IgG4) assay in management of patients suffering from food intolerance was assessed. A total of 22 asymptomatic healthy subjects and 68 patients with symptoms referred for suspected food intolerance were studied. Serum IgG4 to 19 common foods... | 18,839,470 |
Microflora of bile aspirates in patients with acute cholecystitis with or without cholelithiasis: a tropical experience. | The current study determined the spectrum of biliary microflora with special emphasis on enteric fever organisms in patients with acute cholangitis with and without cholelithiasis or other biliary diseases. The patients were divided into three groups: Group A consisted of patients with acute cholecystitis with cholelit... | 18,839,486 |
[Cell cycle alterations of human embryo lung fibroblasts induced by benzo(a)pyrene is positively regulated by cyclin D1 and CDK4]. | To study the effects of benzo(a)pyrene (B(a)P) on the cell cycle distributions and expression of cell cycle regulated protein cyclin D1 and CDK4 in human embryo lung fibroblasts (HELF), and to investigate the relationship between the expression of both cyclin D1 and CDK4 proteins and the cell cycle alterations. Antisen... | 18,839,518 |
[CBS gene variations and serum homocysteine level associated with congenital heart defects]. | To study the relationship between two common CBS gene variations, tHcy level and CHDs in a nuclear family-based study. 234 Chinese CHDs patients and their biological parents were recruited as case groups. And another 136 normal individuals and their parents were recruited as controls. The CBS gene 844ins68 and G919A va... | 18,839,533 |
[Survey of the dietary status and physical activity level and fitness of college freshmen in Chengdu]. | To study the effect of diet and physical activity on the physical fitness of college students. 1200 freshmen come from different five universities in Chengdu were random recruited chosen (600 males and 600 females). A semi-quantitative food frequency questionnaire and international physical activity questionnaire were ... | 18,839,540 |
[Effects of simulated wetland water change on the decomposition and nitrogen dynamics of Calamagrostis angustifolia litter]. | From May 2005 to September 2006, the potential effects of wetland water change on the decomposition and nitrogen (N) dynamics of the typical meadow Calamagrostis angustifolia (TMC) and marsh meadow C. angustifolia (MMC) litters were studied by litterbag technique in the typical depressional wetland in the Sanjiang Plai... | 18,839,554 |
[Hydro-chemical characteristics in the Danjiangkou Reservoir (water source area of the middle route of the south to north water transfer project), China]. | TDS, pH and major ions in the Danjiangkou Reservoir, the water source area of the Middle Route of the South to North Water Transfer Project of China were monitored during the period of 2004-2006 to systemically analyze hydro-chemical characteristics and water chemistry type. Analysis of variance (ANOVA) and correlation... | 18,839,558 |
[Dynamic rule of organic matter removal in vertical-flow constructed wetland]. | Based upon the analysis of the removal rate and form change of the organic pollutants with the different height of the vertical-flow constructed wetland, it comes to the conclusion of the average longitudinal removal rate of variant forms organics and presents the influent concentration and the hydraulic load curve. Th... | 18,839,567 |
[Promoting high-temperature hydrolysis under alkaline condition]. | The effect of alkaline thermal hydrolysis method on excess sludge and its characteristic parameters(such as soluble chemical oxygen demand, volatile fatty acids, ammonia-nitrogen, pH value, sludge concentration, etc.) were investigated. The results show that the addition of alkali can reduce the resistance of the sludg... | 18,839,582 |
[Content of soil heavy metals and characteristics of environmental quality in tea plantations of Changsha Baili Tea Zone]. | The distributing and changing characteristics and content of soil heavy metals was studied using methods of field survey and sampling, indoor analysis, and pollution index were used to investigate the soil environmental quality in the tea plantations of Changsha Baili Tea Zone. The results showed that the content of so... | 18,839,593 |
[Assessment of health risk for mined soils based on critical thresholds for lead, zinc, cadmium and copper]. | Contents of heavy metals (Pb, Zn, Cd, Cu) in soils in terms of point, line and area around a lead/zinc mine in Dongguan town, Zhejiang, China, were investigated to evaluate environmental quality based on index and health risk assessment model for safety of soils-human. The order for average contents of Pb, Zn, Cd, Cu i... | 18,839,594 |
[Effect of Cd on remediation of DDT contaminated soil using different laccase forms]. | This study investigated the effect of Cd on remediation of DDT contaminated soil using free laccase and immobilized reversed micelles laccase. The results show: degradation rates of ingredients of DDT and total DDT reduced with increasing of Cd concentration, the higher percentage of components in total DDT, the greate... | 18,839,595 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.