title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Increased thyroid blood flow in the hypoechoic lesions in patients with recurrent, painful Hashimoto's thyroiditis at the time of acute exacerbation. | We report two cases with painful Hashimoto's thyroiditis, who developed recurrent fever and painful thyroid. Glucocorticoid treatment was transiently successful but tenderness in the thyroid gland and fever developed when glucocorticoid was tapered. One patient underwent total thyroidectomy uneventfully. As is well kno... | 18,840,927 |
Application of the Life Change Unit model for the prevention of accident proneness among small to medium sized industries in Korea. | Behavior models have provided an accident proneness concept based on life change unit (LCU) factors. This paper describes the development of a Korean Life Change Unit (KLCU) model for workers and managers in fatal accident areas, as well as an evaluation of its application. Results suggest that death of parents is the ... | 18,840,937 |
Vibration-isolating performance of cotton work gloves based on newly issued JIS T8114. | The mean vibration transmissibility values were measured for cotton work gloves commonly used in vibration-generating workplaces to evaluate the vibration isolating performance of cotton work gloves. The mean vibration transmissibility values of work cotton gloves were compared with those of four types of anti-vibratio... | 18,840,938 |
Effects of adjustable sit-stand VDT workstations on workers' musculoskeletal discomfort, alertness and performance. | Adjustable sit-stand workstations, which are designed to allow workers to sit and stand autonomously while working, were examined to identify the effects on workers' musculoskeletal discomfort, alertness and performance. Twenty-four healthy subjects participated in the study. The subjects were required to do an English... | 18,840,942 |
[Iodine concentration in current Japanese foods and beverages]. | In the present study, we determined iodine concentration in commonly consumed foods in Japan. One hundred thirty-nine foods and beverages were purchased from local markets and convenience stores. These samples were examined for iodine concentration by using gas chromatography after ashing or extraction. The iodine conc... | 18,840,947 |
[Does the population approach increase health inequality? Vulnerable population approach as an alternative strategy]. | The population approach is well recognized as an effective strategy to improve population health, as well as the population-at-risk approach. It aims to decrease risk exposure of the total population through a change of contextual conditions. However, the population approach has the possibility of increasing health ine... | 18,840,948 |
[A new method of measuring temporal resolution for computed tomography]. | In this study, we proposed a new method of measuring temporal resolution using an impulse signal in the time domain in computed tomography (CT). We employed a metal ball with a diameter of 11 mm as the source of the impulse signal, which was shot to a slice plane at a very fast speed during scanning, along the perpendi... | 18,840,955 |
Immunohistochemical study of cathepsin D in the spinal cords of rats with clip compression injury. | This study examined the temporal expression of cathepsin D protein and its cellular localization in the spinal cords of rats after a clip compression injury to determine the involvement of cathepsin D in spinal cord injury (SCI). Western blot analysis showed a significant increase in the approximately 31-kDa active for... | 18,840,968 |
Granulocyte colony-stimulating factor has no adverse effects on atherosclerotic lesions in high cholesterol-fed miniature Swine. | Granulocyte colony-stimulating factor (G-CSF) is widely used to mobilize peripheral blood stem cells, and expected to restore cardiac function for patients with coronary artery diseases as a consequence of progression of atherosclerosis. Safety issues related to the administration of G-CSF to these patients, however, a... | 18,840,969 |
Mapping of rRNA gene loci in the mice, Mus musculus molossinus (Japan) and Mus musculus musculus (Russia) by double color FISH. | Ribosomal RNA gene (rDNA) loci of Russian Mus musculus musculus and of Japanese Mus musuculus molossinus were mapped by double color FISH. The total number of rDNA loci was varied from 5 to 12, although the loci on chromosomes 12, 15, 16, 18, and 19 were common to all mice examined. Instead, polymorphisms of the rDNA l... | 18,840,979 |
Chromogranin A as an alternative to 5-hydroxyindoleacetic acid in the evaluation of symptoms during treatment of patients with neuroendocrine Tumors. | Urinary 5-HIAA excretion is a well-known marker in neuroendocrine tumors (NETs), but it has a low sensitivity and the 24-hour collection is inconvenient for patients. Chromogranin A (CgA) is a promising marker, but a thorough evaluation during follow-up is still lacking. 39 patients with metastatic gastrointestinal NET... | 18,840,995 |
Relation of chronic obstructive pulmonary disease exacerbations to FEV(1)--an intricate tango. | This article provides a brief review of the complex interrelationships that surround chronic obstructive pulmonary disease exacerbations and lung function, particularly FEV(1). Areas of discussion include a consideration of baseline lung function as a risk factor for exacerbation, the magnitude and duration of lung fun... | 18,840,996 |
Pulse volume changes recorded by air plethysmography during single hemodialysis sessions. | This study investigated whether fluid removal during a hemodialysis (HD) session affects the results of non-invasive pulse volume recording (PVR) on the lower extremities. The results of PVR by air plethysmography (Portable Vascular Laboratory; BioMedix, USA) were compared with bioelectrical impedance analysis (Nutrigu... | 18,841,005 |
Neural correlates of the Clock Drawing Test performance in Alzheimer's disease: a FDG-PET study. | This study aimed to identify the functional neuroanatomical correlates of impaired clock drawing test (CDT) performance in patients with Alzheimer's disease (AD). The CDT was administered to 71 patients with AD, and regional cerebral glucose metabolism (rCMglc) was measured by positron emission tomography (PET). Correl... | 18,841,015 |
Multi-center comparison of medial temporal atrophy in patients with Alzheimer's disease--data from the ICTUS study. | To study multi-center variability of medial temporal lobe atrophy (MTA) in patients with Alzheimer's disease (AD) recruited in a European observational study of AD. 117 mild to moderate AD patients from 5 European centers (Amsterdam, The Netherlands; Brescia and Genova, Italy; Mannheim, Germany; Pamplona, Spain) had ma... | 18,841,016 |
Triple-negative breast cancer. | Triple-negative breast cancer has been of great interest to oncologists because these cancers do not benefit from hormonal therapies or treatments targeted against human epidermal growth factor receptor 2 receptors. The only systemic therapy currently available is chemotherapy, and prognosis remains poor. We would like... | 18,841,042 |
Erythropoietin in cancer-related anemia. | Erythropoiesis-stimulating agents reduce the transfusion requirements of anemic cancer patients receiving chemotherapy. Risks associated with the use of erythropoiesis-stimulating agents in cancer patients have more recently been identified. Several recently published phase III trials and a meta-analysis have shown an ... | 18,841,051 |
Ilizarov method to correct limb length discrepancy after limb-sparing hemipelvectomy. | Pelvic resection for a sarcoma in young patients is challenging, with significant functional, psychological, and social implications. We report the case of a 26-year-old former Ewing's sarcoma patient in whom the Ilizarov technique was applied to address 6 cm of leg length discrepancy secondary to internal hemipelvecto... | 18,841,062 |
Effect of crude sulphated polysaccharide from brown algae against acetaminophen-induced toxicity in rats. | This study was conducted to examine the protective role of crude polysaccharide from brown seaweed Sargassum polycystum against acetaminophen-induced abnormality in blood glucose, serum albumin/globulin ratio, and liver glycogen, lactate, and pyruvate. Liver and renal tissue histology was performed to confirm the effic... | 18,841,170 |
Paediatric inflammatory bowel disease in New Zealand. | To determine the incidence, presentation, and initial management of paediatric inflammatory bowel disease in New Zealand. A prospective study in collaboration with the New Zealand Paediatric Surveillance Unit was undertaken between 2002-2003. Paediatricians and healthcare professionals working with children were survey... | 18,841,182 |
High prevalence of gout in patients with Type 2 diabetes: male sex, renal impairment, and diuretic use are major risk factors. | Gout and hyperuricaemia are recognised features of the metabolic syndrome. The objective of this study was to determine the prevalence of gout in patients with diabetes. We studied 292 consecutive outpatients attending diabetes clinics between August and September 2005. A self-reported history of gout was obtained, and... | 18,841,184 |
When should I do rural general practice? A qualitative study of job/life satisfaction of male rural GPs of differing ages in New Zealand. | There is a shortage of rural general practitioners in New Zealand (NZ), and many are approaching retirement. This qualitative study was undertaken to investigate the perceived advantages and disadvantages of rural general practice at various stages of family life of male NZ-trained GPs. Semi-structured interviews were ... | 18,841,186 |
The secondary abdominal compartment syndrome: not just another post-traumatic complication. | The secondary abdominal compartment syndrome (ACS) is defined as the presence of organ dysfunction with concurrent intra-abdominal hypertension (IAH) in a scenario lacking primary intraperitoneal injury or intervention. This state appears to be related to visceral, abdominal wall and retroperitoneal edema and ascites i... | 18,841,232 |
SNPinProbe_1.0: a database for filtering out probes in the Affymetrix GeneChip human exon 1.0 ST array potentially affected by SNPs. | The Affymetrix GeneChip(R) Human Exon 1.0 ST array (exon array) is designed to measure both gene-level and exon-level expression in human samples. This exon array contains approximately 1.4 million probesets consisting of approximately 5.4 million probes and profiles over 17,000 well-annotated gene transcripts in the h... | 18,841,244 |
THE RACE/ETHNICITY DISPARITY IN MISDEMEANOR MARIJUANA ARRESTS IN NEW YORK CITY. | RESEARCH SUMMARY: This article examines the growth in marijuana misdemeanor arrests in New York City (NYC) from 1980 to 2003 and its differential impact on blacks and Hispanics. Since 1980, the New York City Police Department (NYPD) expanded its use of arrest and detention for minor offenses under its quality-of-life (... | 18,841,246 |
Polyelectrolyte multilayer films of controlled stiffness modulate myoblast cells differentiation. | Beside chemical properties and topographical features, mechanical properties of gels have been recently demonstrated to play an important role in various cellular processes, including cell attachment, proliferation, and differentiation. In this work, we used multilayer films made of poly(L-lysine)/Hyaluronan (PLL/HA) o... | 18,841,249 |
GOVERNING GENETIC DATABASES: COLLECTION, STORAGE AND USE. | This paper provides an introduction to a collection of five papers, published as a special symposium journal issue, under the title: "Governing Genetic Databases: Collection, Storage and Use". It begins by setting the scene, to provide a backdrop and context for the papers. It describes the evolving scientific landscap... | 18,841,252 |
Isolated right ventricular infarction due to occlusion of the right ventricular branch in the absence of percutaneous coronary intervention. | Isolated right ventricular myocardial infarction accounts for only 3% of all infarctions. It has previously been reported as a complication of percutaneous coronary intervention involving the right coronary artery secondary to occlusion of the right ventricular branch. In the present report, a patient is described in w... | 18,841,260 |
Protective effects of activated protein C in sepsis. | Sepsis remains a complex syndrome associated with significant morbidity and mortality. It is now widely accepted that the pathways of inflammation, coagulation, apoptosis, and endothelial permeability are intimately linked in sepsis pathophysiology. The clinical success of activated protein C (APC), a natural anticoagu... | 18,841,279 |
Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. | Omega-3 fatty acids (n-3 FA) from oily fish are clinically useful for lowering triglycerides and reducing risk of heart attacks. Accordingly, patients at risk are often advised to take both aspirin and n-3 FA. However, both of these agents can increase bleeding times, and the extent to which the combination inhibits pl... | 18,841,286 |
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy. | Human embryonic stem cells (hESC) are now routinely cultured in many laboratories, and differentiation protocols are available to generate a large variety of cell types. In an ongoing ethical debate opinions of different groups are based on varying sets of religious, historical, cultural and scientific arguments as wel... | 18,841,314 |
Abnormal short latency afferent inhibition in early Alzheimer's disease: a transcranial magnetic demonstration. | The pathogenesis of Alzheimer's disease (AD) appears to involve several different mechanisms, the most consistent of which is an impairment of cholinergic neurotransmission; however, there is controversy about its relevance at the early stage of disease. A transcranial magnetic stimulation (TMS) protocol based on coupl... | 18,841,323 |
Screening of DHFR-binding drugs by MALDI-TOFMS. | The class of antimetabolite chemotherapeutical agents has been used to treat cancers in humans for almost 50 years and gives significant results by binding dihydrofolate reductase (DHFR), a key enzyme in DNA synthesis. Therefore, finding new active compounds inhibiting DNA synthesis through their binding to DHFR is of ... | 18,841,351 |
Magnetic nanoparticle imaging by means of minimum norm estimates from remanence measurements. | In magnetic nanoparticle imaging, magnetic nanoparticles are coated and functionalized to bind to specific targets. After measuring their magnetic relaxation or remanence, their distribution can be determined by means of inverse methods. The reconstruction algorithm presented in this paper includes first a dipole fit u... | 18,841,404 |
Response of phytoplankton community to low-dose atrazine exposure combined with phosphorus fluctuations. | The effects of atrazine on a controlled phytoplankton community derived from a natural freshwater wetland exposed to low doses of this photosynthesis-inhibiting herbicide were examined. The community was exposed for 7 weeks to doses of 0.1, 1, and 10 microg L(-1) atrazine, combined with changes in nutrient concentratio... | 18,841,407 |
Management of mandibular fractures in a developing country: a review of 314 cases from two urban centers in Nigeria. | This study was designed to establish the current demographic and treatment patterns of mandibular fractures in two urban centers (Lagos University Teaching Hospital, Lagos, and National Hospital, Abuja) in Nigeria. All cases of mandibular fractures diagnosed and treated at the Department of Oral and Maxillofacial Surge... | 18,841,410 |
Home ranges of bottlenose dolphins (Tursiops truncatus) in the Indian River Lagoon, Florida: environmental correlates and implications for management strategies. | Photo-identification surveys conducted between 2002 and 2005 were used to determine dolphin home ranges and site fidelity within the Indian River Lagoon (IRL), Florida. The IRL was divided into six segments based on hydrodynamics and geographic features for purposes of characterization. Among the 615 dolphins with iden... | 18,841,416 |
Concomitant laparoscopic adjustable gastric banding and laparoscopic cholecystectomy in a super-obese patient with situs inversus totalis who previously underwent intragastric balloon placement. | Laparoscopic adjustable gastric banding has been increasingly performed since its introduction in 1990. Situs inversus totalis is a rare anomaly in which transposition of organs to the opposite side of the body occurs. Laparoscopic gastric banding in such few patients has been reported in the literature. We discuss a s... | 18,841,426 |
The utility of the Beck Depression Inventory in a bariatric surgery population. | The Beck Depression Inventory (BDI) is commonly used in bariatric surgery psychological assessments. However, several items may be measuring physical consequences of obesity (e.g., sleep disturbance, chronic pain, or sexual dysfunction) rather than depressive symptoms. Bariatric surgery candidates (n = 210) completed a... | 18,841,428 |
Reliability across studies from the functional assessment of cancer therapy-general (FACT-G) and its subscales: a reliability generalization. | The aim of this study was to conduct a reliability generalization of the Functional Assessment of Cancer Therapy-General (FACT-G) and its subscales to examine variation in score reliability across all published studies. We reviewed 344 publications based on predetermined criteria. About 78 published studies reported Cr... | 18,841,493 |
Reliability and validity of the Korean version of UKU-SERS-Pat in patients with bipolar disorder. | Poor drug compliance caused by side effects is an important factor affecting clinical outcomes. Thus reliable and valid rating scales to accurately evaluate the side effects of medications in their early stages are needed. This study aimed to develop the Korean version of the Udvalg for Kliniske Undersøgelser (UKU) Sid... | 18,841,509 |
Risk factors of the failure of surfactant treatment by transient intubation during nasal continuous positive airway pressure in preterm infants. | We sought to identify risk factors and neonatal outcomes associated with the failure of the INSURE method ( INtubation- SURfactant- Extubation) during nasal continuous positive airway pressure for preterm infants with respiratory distress syndrome. We used a retrospective analysis of the prenatal histories, clinical co... | 18,841,536 |
[Treatment of headaches among the Aborigines of Tierra de Fuego. A comparison with other anthropological studies]. | Several different indigenous groups (Yamana, Selk'nam, Alacaluf, Haush) used to inhabit the Patagonian region of Tierra de Fuego, but are now extinct. To analyse the healing practices that these prehistoric aborigines used to treat headaches and to compare them with those observed in other anthropological studies. The ... | 18,841,550 |
[The mutation and expression of MUS81 gene in laryngeal squamous cell carcinoma]. | To investigate the association of mutations and expression of MUS81 gene with the tumorigenesis and progression of laryngeal squamous cell carcinoma (LSCC). PCR-SSCP and DNA sequencing were carried out to examine mutations at exons 9 and 10 of MUS81 gene in 42 LSCC samples, with paired adjacent normal laryngeal tissues... | 18,841,572 |
[Clinical and cytogenetic features of hematologic malignancies associated with acquired trisomy 21]. | To investigate the association between trisomy 21 abnormalities and the clinical and cytogenetic features of hematologic malignancies. Chromosome preparations were made on bone marrow cells by using direct method and/or unstimulated short-term cultures. Karyotypes were analyzed by R-banding. Thirteen patients (1.5%) wi... | 18,841,576 |
Experiments in payment. | Everyone agrees: The nation's health care payment system is a mess. Today, dozens of reform ideas are being tested, and while there is little coordination, the goal is the same: Get more value for the health care buck in terms of quality and results. Some experts say this is the beginning of a "quiet revolution" in pay... | 18,841,682 |
Host-microbe symbiosis: the squid-Vibrio association--a naturally occurring, experimental model of animal/bacterial partnerships. | Many, if not most, animals have specific symbiotic relationships with bacterial partners. Recent studies suggest that vertebrates create alliances with highly complex consortia of hundreds to thousands of prokaryotic phylotypes. In contrast, invertebrates often have binary associations, i.e., relationships with a popul... | 18,841,707 |
Effect of energy density on color stability in dental resin composites under accelerated aging. | The effects of the energy density that is used for polymerization on properties of dental resin composites are well known. However, few studies relate color stability to this factor. The aim of this study was to assess color changes (deltaE*), in vitro, in terms of accelerated aging under UV exposure of specimens prepa... | 18,841,740 |
Film thickness of resin cements used with adhesive systems. | The final film thickness of a resin adhesive and a resin cement could be affected by previous polymerization of the adhesive systems on dentin surfaces. The aim of this work was to evaluate changes in the film thickness of dual resin based cements with their adhesives as a function of polymerization of the latter on de... | 18,841,743 |
Relationship between oral health in children and poverty related factors. | The aim of this investigation was to analyze the variables related to poverty and its influence on oral health in children living in a suburban area ofBuenos Aires, Argentina. The study population consisted of 1,049 children. 579 children at social risk (Group I) were recruited from five neighborhoods with critical lac... | 18,841,746 |
Passive drainage through the vestibular oblique incision in impacted inferior third molar surgery: a preliminary study. | The aim of the present study was to clinically evaluate the variables pain, swelling and trismus when two different suture techniques were applied in surgery of impacted lower third molars. The sample comprised 20 patients of both genders participating in the clinical trial at the Division of Oral and Maxillofacial Sur... | 18,841,747 |
Protein content in irrigating solutions in contact with pulp tissue. | Endodontic irrigating solutions may have different effects, one of which is dissolving pulp tissue. The capacity of different irrigants to dissolve vital and necrotic pulp tissue was evaluated in vitro by means of a quantitative and qualitative study of total soluble pulp protein. Vital pulps and pulps with induced nec... | 18,841,748 |
[Limited determination of trace toxical aconitine alkaloid in guifudihuang pills]. | To establish a capillary electrophoresis with field-amplified sample stacking method for the separation and determination of aconitine alkaloid in Guifudihuang pills. An uncoated fused-silica capillary column (50 microm x 43 cm, effective length 35 cm) was used. The running buffer was 50 mmol x L(-1) phosphate electrol... | 18,841,765 |
[Experimental research on application of hydrodynamic acoustic generator in extraction of Chinese medicine]. | To study the hydrodynamic ultrasonic energy extraction technique for Chinese Medicine. The content of baicalin in Radix Scutellariae extracts and total flavones in Folium Ginkgo extracts were as indexes respectively and measured by high performance liquid chromatography. We investigated the hydrodynamic ultrasonic ener... | 18,841,766 |
[Effects and mechanism of CD4+ CD25+ regulatory T cells in mouse experimental colitis treated by CLYSTER No. 1]. | To explore the effects and mechanism of CD4+ CD25+ regulatory T cells (Tregs) in mouse experimental colitis treated by CLYSTER No. 1. The mouse model of experimental colitis was established by dinitrochlorobenzene (DNCB)-acetic acid (AA) in mice DNCB and AA. Adult KM mouse were randomly divided into four groups: normal... | 18,841,781 |
[Diagnosis and therapy of choanal polyps from posterior ethmoid sinus]. | To investigate the clinical feature, diagnosis and endoscopic surgery of choanal polyps (CP) from posterior ethmoid sinus. Eleven cases with CP from posterior ethmoid sinus treated by endoscopic endonasal surgery between January 2002 to June 2007 were retrospectively reviewed. Clinical manifestation, intranasal and int... | 18,841,792 |
[Diagnosis and management in parotid lymphoepithelioma-like carcinoma]. | To study the diagnosis and treatment of parotid Lymphoepithelioma-like carcinoma (LELC), and improve the rate of the diagnosis and treatment. Eighteen cases with parotid LELC confirmed pathologically were collected in our department, and the clinical presentation, diagnosis, treatment and prognosis were retrospectively... | 18,841,797 |
[Breast cancer less than 1 cm: bio-morphologic characterization with ER, PgR, Ki67, Her-2/Neu, MDV, MAGS, p53, EGF-R]. | Breast carcinoma is the most common malignant tumour and the main cause of carcinoma death in women. There has been a sharp increase in the detection of breast carcinoma, although mortality is still unvaried. In the last ten years the incidence of breast cancer measuring less than 1 cm, corresponding to pT1a, pT1b in T... | 18,841,818 |
Extragastrointestinal stromal tumor of the urinary wall bladder: case report and review of the literature. | Most mesenchymal tumours of the gastrointestinal tract are now referred to as gastrointestinal stromal tumours (GISTs). These tumours typically express c-kit (CD117) and CD34; 30-50% are (often focally) positive for alpha-smooth muscle actin, and all are negative for desmin and S100 protein. Recently, mutations in exon... | 18,841,822 |
A pulmonary mucinous cystic tumour of borderline malignancy. | We report a well-documented case of pulmonary mucinous cystic tumour of borderline malignancy involving the left lower lobe. The lesion was found incidentally by chest radiograph and CT scan with a provisional diagnosis of bronchioloalveolar carcinoma. The tumour was 4 cm in its greatest dimension, cystic and filled wi... | 18,841,826 |
Real-time tumor tracking with preprogrammed dynamic multileaf-collimator motion and adaptive dose-rate regulation. | The authors have developed a new method for real-time tumor tracking with dynamic multileaf-collimator (MLC) motion under condition of free breathing. Unlike other previously proposed tumor-tracking methods, their new method uses a preprogrammed dynamic MLC sequence in combination with real-time dose-rate control. This... | 18,841,846 |
Comparison of SNR and CNR for in vivo mouse brain imaging at 3 and 7 T using well matched scanner configurations. | Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) for magnetic resonance microimaging were measured using two nearly identical magnetic resonance imaging (MRI) scanners operating at field strengths of 3 and 7 T. Six mice were scanned using two imaging protocols commonly applied for in vivo imaging of small ... | 18,841,848 |
Monte Carlo calculations of correction factors for plane-parallel ionization chambers in clinical electron dosimetry. | Recent standard dosimetry protocols recommend that plane-parallel ionization chambers be used in the measurements of depth-dose distributions or the calibration of low-energy electron beams with beam quality R50 <4 g/cm2. In electron dosimetry protocols with the plane-parallel chambers, the wall correction factor, P... | 18,841,855 |
Geometrical differences in target volumes between slow CT and 4D CT imaging in stereotactic body radiotherapy for lung tumors in the upper and middle lobe. | Since stereotactic body radiotherapy (SBRT) was started for patients with lung tumor in 1998 in our institution, x-ray fluoroscopic examination and slow computed tomography (CT) scan with a rotation time of 4 s have been routinely applied to determine target volumes. When lung tumor motion observed with x-ray fluorosco... | 18,841,867 |
Proteomic analysis of the hyaloid vascular system regression during ocular development. | We describe a proteomic approach to investigate the differential protein expression patterns and identify the physiologically relevant angiogenic and antiangiogenic factors involved in the hyaloid vascular system regression. Differentially expressed proteins were identified using two-dimensional gel electrophoresis fol... | 18,841,878 |
Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists. | A series of structurally constrained derivatives of the potent H 3 inverse agonist 1 was designed, synthesized, and evaluated as histamine H 3 receptor inverse agonists. As a result, the N-cyclobutylpiperidin-4-yloxy group as in 2f was identified as an optimal surrogate structure for the flexible 1-pyrrolidinopropoxy g... | 18,841,880 |
Highly diastereoselective switchable enantioselective Mannich reaction of glycine derivatives with imines. | Tuning of diastereoselectivity was realized in the Mannich reaction of glycine derivatives with aromatic and aliphatic N-Ts imines using CuClO4-FcPHOX ligand 4b and 4f having an MeO group at the 4-position and F atom at the 3,5-position of the phenyl ring on the P-atom respectively as catalyst, providing either anti- o... | 18,841,892 |
Self-assembly of organic-inorganic hybrid amphiphilic surfactants with large polyoxometalates as polar head groups. | Mn-Anderson-C6 and Mn-Anderson-C16, A type of inorganic-organic hybrid molecules containing a large anionic polyoxometalate (POM) cluster and two C6 and C16 alkyl chains, respectively, demonstrate amphiphilic surfactant behavior in the mixed solvents of acetonitrile and water. The amphiphilic hybrid molecules can slowl... | 18,841,899 |
Triterpene glycosides from Antarctic sea cucumbers. 1. Structure of liouvillosides A1, A2, A3, B1, and B2 from the sea cucumber Staurocucumis liouvillei: new procedure for separation of highly polar glycoside fractions and taxonomic revision. | Five new triterpene glycosides, liouvillosides A1 (1), A2 (2), A3 (3), B1 (4), and B2 (5), have been isolated from the Antarctic sea cucumber Staurocucumis liouviellei along with the known liouvilloside A(6), isolated earlier from the same species, and hemoiedemosides A (7) and B (8), isolated earlier from the Patagoni... | 18,841,904 |
Aza-beta3-cyclotetrapeptides. | The cyclization of aza-beta(3)-tetrapeptides gives access to new CTP (cyclotetrapeptide) analogues. These stereocontrolled templates are assembled without any asymmetric synthesis. X-ray crystallographic structure and NMR analysis show that the macrocyclic scaffold is characterized by a fully cooperative intramolecular... | 18,841,910 |
Interactions between antimicrobial polynorbornenes and phospholipid vesicles monitored by light scattering and microcalorimetry. | Antimicrobial polynorbornenes composed of facially amphiphilic monomers have been previously reported to accurately emulate the antimicrobial activity of natural host-defense peptides (HDPs). The lethal mechanism of most HDPs involves binding to the membrane surface of bacteria leading to compromised phospholipid bilay... | 18,841,926 |
High nuclearity single-molecule magnets: a mixed-valence Mn26 cluster containing the di-2-pyridylketone diolate dianion. | The employment of the dianion (dpkd(2-)) of the gem-diol form of di-2-pyridylketone (dpk) as a tetradentate chelate in manganese chemistry is reported, and the synthesis, crystal structure, and magnetochemical characterization of [Mn26O16(OMe)12(dpkd)12(MeOH)6](OH)6 x solv (3 x solv) are described. The reaction of Mn(C... | 18,841,928 |
Ab initio study of the diatomic fluorides FeF, CoF, NiF, and CuF. | The late-3d transition-metal diatomic fluorides MF = FeF, CoF, NiF, and CuF have been studied using variational multireference (MRCI) and coupled-cluster [RCCSD(T)] methods, combined with large to very large basis sets. We examined a total of 35 (2S+1)|Lambda| states, constructing as well 29 full potential energy curve... | 18,841,949 |
Spiroacetal biosynthesis in insects from Diptera to Hymenoptera: the Giant Ichneumon wasp Megarhyssa nortoni nortoni Cresson. | The volatile components of the mandibular gland secretion generated by the Giant Ichneumon parasitoid wasp Megarhyssa nortoni nortoni Cresson are mainly spiroacetals and methyl ketones, and all have an odd number of carbon atoms. A biosynthetic scheme rationalizing the formation of these diverse components is presented... | 18,841,963 |
Formation of spectral intermediate G-C and A-T anion complex in duplex DNA studied by pulse radiolysis. | The dynamics of electron adducts of 2'-deoxynucleotides and oligonucelotides (ODNs) were measured spectroscopically by nanosecond pulse radiolysis. The radical anions of the nucleotides were produced within 10 ns by the reaction of hydrated electrons (e(aq)(-)) and were protonated to form the corresponding neutral radi... | 18,841,971 |
Inhibition of Angiotensin converting enzyme I caused by autolysis of potato proteins by enzymatic activities confined to different parts of the potato tuber. | Autolysis of protein isolates from vascular bundle and inner tuber tissues of potato (Solanum tuberosum) enhanced the inhibition of the angiotensin converting enzyme I (ACE), a biochemical factor affecting blood pressure (hypertension). The physiological age of the tuber affected the strength of ACE inhibition, the rat... | 18,841,984 |
Logistic regression modeling of cropping systems to predict fumonisin contamination in maize. | The aims of this research were to monitor the presence of fumonisins in maize crops in northern Italy over a 6 year period, to study the role of the cropping system on fumonisin levels, and to contribute to the development of a predictive system for fumonisin contamination. In the 6 year period from 2002 to 2007, 438 m... | 18,841,987 |
Electrochemically modulated liquid-liquid extraction of ionized drugs under physiological conditions. | Electrochemically modulated liquid-liquid extraction (EMLLE) enables the selective extraction and separation of ions from mixtures by choice of an applied interfacial potential difference. The extraction of ionized drugs from artificial urine is reported in this paper. The artificial urine matrix was characterized by c... | 18,841,995 |
O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis. | The kinetic pathway of CysM, a cysteine synthase from Mycobacterium tuberculosis, was studied by transient-state kinetic techniques. The expression of which is upregulated under conditions of oxidative stress. This enzyme exhibits extensive homology with the B-isozymes of the well-studied O-acetylserine sulfhydrylase f... | 18,842,002 |
P450 versus P420: correlation between cyclic voltammetry and visible absorption spectroscopy of the immobilized heme domain of cytochrome P450 BM3. | Cyclic voltabsorptometry is used for the first time to distinguish and characterize electrochemically the active (P450) and inactive (P420) forms of cytochromes P450 immobilized on an electrode during voltammetry experiments. This was achieved by using the heme domain (BMP) of the bacterial cytochrome P450 BM3 from Bac... | 18,842,012 |
Synthesis of 1,1-dialkylindolium-2-thiolates via base-induced transformation of 4-(2-chloro-5-nitrophenyl)-1,2,3-thiadiazole in the presence of secondary amines. | 4-(2-Chloro-5-nitrophenyl)-1,2,3-thiadiazole undergoes ring-opening to produce a thioketene intermediate that reacts with secondary amines forming 2-(2-chloro-5-nitrophenyl)-N,N-dialkylthioacetamides. Intramolecular cyclization of these thioamides via nucleophilic substitution of the halogen on the aromatic ring afford... | 18,842,029 |
The promiscuity of beta-strand pairing allows for rational design of beta-sheet face inversion. | Recent studies suggest the dominant role of main-chain H-bond formation in specifying beta-sheet topology. Its essentially sequence-independent nature implies a large degree of freedom in designing beta-sheet-based nanomaterials. Here we show rational design of beta-sheet face inversions by incremental deletions of bet... | 18,842,042 |
Direct visualization of reversible switching of micropatterned polyelectrolyte brushes on gold surfaces using laser scanning confocal microscopy. | We apply confocal fluorescence microscopy for real time studies of reversible conformational changes of poly(methacryloyloxyethyl phosphate) (PMEP) brushes chemically grafted onto gold substrates. Oregon green 488 fluorophores chemically attached onto the PMEP polymers were used as reporters for probing the conformatio... | 18,842,063 |
Impact of model perfumes on surfactant and mixed surfactant self-assembly. | The impact of some model perfumes on surfactant self-assembly has been investigated, using small-angle neutron scattering. A range of different model perfumes, with differing degrees of hydrophilicity/hydrophobicity, have been explored, and in order of increasing hydrophobicity include phenyl ethanol (PE), rose oxide (... | 18,842,064 |
Adaptive strategies for reading with a forced retinal location. | Forcing normal-sighted participants to use a distinct parafoveal retinal location for reading, we studied which part of the visual field is best suited to take over functions of the fovea during early stages of macular degeneration (MD). A region to the right of fixation lead to best reading performance and most natura... | 18,842,077 |
Perceptual multistability predicted by search model for Bayesian decisions. | Perceptual multistability refers to the phenomenon of spontaneous perceptual switching between two or more likely interpretations of an image. Although frequently explained by processes of adaptation or hysteresis, we show that perceptual switching can arise as a natural byproduct of perceptual decision making based on... | 18,842,083 |
Detection of skewed symmetry. | This study examined the ability of human observers to discriminate between symmetric and asymmetric planar figures from perspective and orthographic images. The first experiment showed that the discrimination is reliable in the case of polygons, but not dotted patterns. The second experiment showed that the discriminat... | 18,842,085 |
Sinorhizobium meliloti regulator MucR couples exopolysaccharide synthesis and motility. | In order to enter symbiosis with its legume partner, Sinorhizobium meliloti requires regulatory systems for the appropriate responses to its environment. For example, motility is required for the chemotactic movement of bacteria toward the compounds released by its host, and exopolysaccharides (EPS) are required for ba... | 18,842,098 |
Drosophila models of neurodegenerative diseases. | Neurodegenerative diseases are progressive disorders of the nervous system that affect specific cellular populations in the central and peripheral nervous systems. Although most cases are sporadic, genes associated with familial cases have been identified, thus enabling the development of animal models. Invertebrates s... | 18,842,101 |
LC-MSsim--a simulation software for liquid chromatography mass spectrometry data. | Mass Spectrometry coupled to Liquid Chromatography (LC-MS) is commonly used to analyze the protein content of biological samples in large scale studies. The data resulting from an LC-MS experiment is huge, highly complex and noisy. Accordingly, it has sparked new developments in Bioinformatics, especially in the fields... | 18,842,122 |
Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases. | Because of its polygenic nature, Alzheimer's disease is believed to be caused not by defects in single genes, but rather by variations in a large number of genes and their complex interactions. A systems biology approach, such as the generation of a network of co-expressed genes and the identification of functional mod... | 18,842,138 |
The accuracy of symptoms, signs and diagnostic tests in the diagnosis of left ventricular dysfunction in primary care: a diagnostic accuracy systematic review. | To assess the accuracy of findings from the clinical history, symptoms, signs and diagnostic tests (ECG, CXR and natriuretic peptides) in relation to the diagnosis of left ventricular systolic dysfunction (LVSD) in a primary care setting. Diagnostic accuracy systematic review, we searched Medline (1966 to March 2008), ... | 18,842,141 |
Characterization of ten novel Ty1/copia-like retrotransposon families of the grapevine genome. | Retrotransposons make a significant contribution to the size, organization and genetic diversity of their host genomes. To characterize retrotransposon families in the grapevine genome (the fourth crop plant genome sequenced) we have combined two approaches: a PCR-based method for the isolation of RnaseH-LTR sequences ... | 18,842,156 |
Mast cells and chemokines. | Chemokines are small proteins (8-12 kD polypeptides) secreted by the cells of innate and adaptive immunity that mediate many of the functions of these cells, including recruitment of other cells. They are classified into families: CC, CXC and CX3C. CXC chemoattract mainly on neutrophils and CC act mainly on monocytes, ... | 18,842,167 |
Is there an association between antiphospholipid antibodies and psoriasis? | Ever increasing evidence supports the association between psoriasis and cardiovascular risk. Antiphospholipid antibodies (APAs), which can occur in many autoimmune diseases, are considered prothrombotic and have been associated with atherosclerosis. The aim of this study is to evaluate the prevalence and levels of APAs... | 18,842,175 |
Effect of impaired glucose tolerance during pregnancy on the expression of VEGF receptors in human placenta. | The aim of the present study was to determine the expression of vascular endothelial growth factor (VEGF) receptors VEGFR-1, VEGFR-2 and VEGFR-3 in placentas from pregnancies complicated by altered glycaemia. Placentas from women with physiological pregnancies (Group 1), pregnancies complicated by minor degree of gluco... | 18,842,181 |
Porcine embryos produced after intracytoplasmic sperm injection using xenogeneic pig sperm from neonatal testis tissue grafted in mice. | Embryo development after homologous intracytoplasmic sperm injection (ICSI) with sperm from testis tissue xenografts from pigs or any other farm animal species has not been evaluated critically. Here, we report development of porcine embryos in vitro following ICSI with sperm retrieved from xenografted neonatal pig tes... | 18,842,182 |
Molecular control of mitochondrial function in developing rhesus monkey oocytes and preimplantation-stage embryos. | The mitochondrion undergoes significant functional and structural changes, as well as an increase in number, during preimplantation embryonic development. The mitochondrion generates ATP and regulates a range of cellular processes, such as signal transduction and apoptosis. Therefore, mitochondria contribute to overall... | 18,842,187 |
[Structured review of activities of daily living measures in older people]. | the present article evaluates the evidence relating to the conceptual adaptation, applicability and psychometric properties of activities of daily living measures in Spanish elderly people. to obtain original documents, electronic searches were carried out in Spanish (IME and ISOC) and international databases (MEDLINE,... | 18,842,201 |
[Cognitive markers to discriminate between mild cognitive impairment and normal ageing]. | mild cognitive impairment (MCI) has been characterized as a transitional stage between normal ageing and dementia. The aim of the present study was to examine differences between normal ageing and MCI in the performance of several cognitive tests. These differences might serve as differential markers. we performed a lo... | 18,842,203 |
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