title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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[Quality of life specific questionnaire for constipated patients: development and validation of CVE-20]. | Although constipation affects quality of life, questionnaires hardly exist for its evaluation. We aimed to develop and validate a questionnaire able to measure the quality of life in patients with constipation. A Spanish multicenter study was performed in 2 stages: a) questionnaire development (open interview to patien... | 18,842,210 |
[Posterior reversible leukoencephalopathy in a patient with postpartum eclampsia]. | We report the clinical-radiological case of a 25 year-old female patient who developed reversible posterior leukoencephalopathy syndrome (RPLS) in the postpartum period, without evidence of preeclampsia-eclampsia or chronic arterial hypertension. RPLS is associated with diverse clinical entities including eclampsia. Te... | 18,842,228 |
[Characterization and molecular epidemiology of ESBL in Escherichia coli and Klebsiella pneumoniae in 11 Spanish hospitals (2004)]. | The epidemiological distribution of extended-spectrum beta-lactamase (ESBL) types in Escherichia coli and Klebsiella pneumoniae was evaluated in various hospitals in Spain and compared with previous studies. A total of 11 Spanish hospitals participated in this study. Each center collected the first 15 isolates of E. co... | 18,842,234 |
Fragrance material review on 1-methyl-2-(1-methylpropyl) cyclohexyl acetate. | A toxicologic and dermatologic review of 1-Methyl-2-(1-methylpropyl)cyclohexyl acetate when used as a fragrance ingredient is presented. | 18,842,249 |
The size, extent and nature of the learning disability nursing research base: a systematic scoping review. | A research base should be of sufficient quality and quantity to inform nursing practice. It must allow nurses to access information about clients' needs and to identify effective strategies for meeting those needs. This paper presents the findings of a scoping review of 'learning disability nursing research'. The revie... | 18,842,263 |
Sperm structure and ultrastructure of the Melittobia hawaiiensis, Perkins and M. australica, Girault (chalcidoidea: eulophidae). | Spermatozoa morphology has, for some years, been used to help answer some phylogenetic questions for Hymenoptera. This is the second study describing spermatozoa morphology of an Eulophidae species in which important characteristics were observed. Melittobia spermatozoa are spiralled and measure approximately 270microm... | 18,842,277 |
Outcomes for older adults in an inpatient rehabilitation facility following hip fracture (HF) surgery. | The purpose of the study was to evaluate patient and system outcomes regarding older community-residing adults who participated in a rehabilitation program following HF surgery. The health care professionals on the rehabilitation unit in this feasibility study had never cared for such patients who were so frail, with m... | 18,842,307 |
Metric issues in the study of eye movements in psychiatry. | This review provides a description of the measurement methods, task definitions and measurement parameters in the study of smooth eye pursuit and saccade-antisaccade tasks in psychiatry. The large heterogeneity in task definitions and definitions of parameters and its potential impact on the large variability of the pa... | 18,842,328 |
[Polyomavirus newly discovered]. | Three new polyoma viruses have been recently identified; two of them, the KI et WU viruses are present in nasopharyngeal aspirates during the course of acute respiratory infections. The incidence of these viruses is low compared to other respiratory viruses and the disease has not shown a high severity of clinical sign... | 18,842,352 |
CNS mastitis: nothing to worry about? | In this paper, we analyzed a very large field data set on intramammary infections (IMI) and the associated somatic cell count (SCC) in dairy cows. The objective of the study was to analyze the impact of coagulase-negative staphylococci (CNS) IMI on cow SCC, both mean and variability, and on the potential of these infec... | 18,842,362 |
Magnetoencephalography using total intravenous anesthesia in pediatric patients with intractable epilepsy: lesional vs nonlesional epilepsy. | Magnetoencephalography (MEG) provides source localization of interictal spikes. We use total intravenous anesthesia (TIVA) with propofol to immobilize uncooperative children. We evaluate the effect of TIVA on interictal spikes in children who have intractable epilepsy with or without MRI lesions. We studied 28 children... | 18,842,368 |
Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women. | To evaluate the effects of soy isoflavone supplementation on profile lipid and endogenous hormone levels. In this double-blind, placebo-controlled study, 47 postmenopausal women 47-66 y of age received 40 mg of isoflavone (n = 25) or 40 mg of casein placebo (n = 22). Cardiovascular risk factors were assessed by evaluat... | 18,842,392 |
[Vascular anomalies of the children's hand]. | Vascular anomalies are common on the hand of children. There are two types of vascular anomalies: the vascular tumours and the vascular malformations. The most frequent vascular tumour is infantile haemangioma. The vascular malformations could be predominantly venous, lymphatic, capillary or arteriovenous. Combined vas... | 18,842,438 |
[Symbrachydactyly]. | Symbrachydactyly is literally defined as a combination of short fingers with syndactyly. Blauth and Gekeler described four types of symbrachydactyly, ranging from simple shortness of middle phalanges to complete absence of digital rays. In type I (short finger) function is quite normal and syndactyly release is usually... | 18,842,444 |
Masseteric-facial nerve coaptation--an alternative technique for facial nerve reinnervation. | Reinnervation of the facial musculature when there is loss of the proximal facial nerve poses a difficult clinical problem. Restoration of spontaneous mimetic motion is the aim and, to this end, the use of cross-facial nerve grafts has long been considered the reconstruction of choice. The nerve to masseter has been us... | 18,842,469 |
Generalized linear discriminant analysis: a unified framework and efficient model selection. | High-dimensional data are common in many domains, and dimensionality reduction is the key to cope with the curse-of-dimensionality. Linear discriminant analysis (LDA) is a well-known method for supervised dimensionality reduction. When dealing with high-dimensional and low sample size data, classical LDA suffers from t... | 18,842,480 |
New delay-dependent stability results for neural networks with time-varying delay. | This paper studies the problem of stability analysis for neural networks (NNs) with a time-varying delay. Unlike the previous works, the activation functions are assumed to be neither monotonic, nor differentiable, nor bounded. By defining a more general type of Lyapunov functionals, some new less conservative delay-de... | 18,842,481 |
Idiopathic cystic artery aneurysm complicated with hemobilia and acute pancreatitis. | Aneurysm of the cystic artery is not common, and it is a rare cause of hemobilia. Most of reported cases are pseudoaneurysms resulting from either an inflammatory process in the abdomen or abdominal trauma. We report a healthy individual who developed hemobilia and acute pancreatitis associated with cystic artery aneur... | 18,842,506 |
Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription. | Cyclooxygenase-2 (COX-2) and Id-1 are overexpressed in a variety of human malignancies. Recently, each of these genes was found to play a role in mediating breast cancer metastasis to the lungs, but their potential interdependence was not evaluated. Hence, the main objective of the current study was to determine whethe... | 18,842,581 |
Inferring population history with DIY ABC: a user-friendly approach to approximate Bayesian computation. | Genetic data obtained on population samples convey information about their evolutionary history. Inference methods can extract part of this information but they require sophisticated statistical techniques that have been made available to the biologist community (through computer programs) only for simple and standard ... | 18,842,597 |
Diagnostic difficulty and error in primary care--a systematic review. | Diagnostic error in primary care can have serious implications for the patient, the clinician and the health-care system, possibly more so than other types of error. To identify common characteristics of diseases that GPs may misdiagnose. Systematic search of the MEDLINE and EMBASE databases for primary research on dia... | 18,842,618 |
Semaphorin 5B is a novel inhibitory cue for corticofugal axons. | Neuronal connectivity is generated by the precise guidance of neuronal growth cones in response to the spatiotemporal distribution of molecular guidance cues in the developing embryo. Here we show that the class 5 semaphorin, Semaphorin 5B, is expressed in regions of the cortex and subcortex flanking the projection of ... | 18,842,660 |
Decoding the cortical transformations for visually guided reaching in 3D space. | To explore the possible cortical mechanisms underlying the 3-dimensional (3D) visuomotor transformation for reaching, we trained a 4-layer feed-forward artificial neural network to compute a reach vector (output) from the visual positions of both the hand and target viewed from different eye and head orientations (inpu... | 18,842,662 |
Functional dissociations of risk and reward processing in the medial prefrontal cortex. | Making a risky decision is a complex process that involves evaluation of both the value of the options and the associated risk level. Yet the neural processes underlying these processes have not so far been clearly identified. Using functional magnetic resonance imaging and a task that simulates risky decisions, we fou... | 18,842,669 |
Timing of genome duplications relative to the origin of the vertebrates: did cyclostomes diverge before or after? | Two rounds of whole-genome duplications are thought to have played an important role in the establishment of gene repertoires in vertebrates. These events occurred during chordate evolution after the split of the urochordate and cephalochordate lineages but before the radiation of extant gnathostomes (jawed vertebrates... | 18,842,688 |
Functional pseudotyping of human immunodeficiency virus type 1 vectors by Western equine encephalitis virus envelope glycoprotein. | We investigated the ability of western equine encephalitis virus envelope glycoproteins (WEEV GP) to pseudotype lentiviral vectors. The titers of WEEV GP-pseudotyped human immunodeficiency virus type 1 (HIV) ranged as high as 8.0 x 10(4) IU/ml on permissive cells. Sera from WEEV-infected mice specifically neutralized t... | 18,842,711 |
RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus. | Rectal transmission is one of the main routes of infection by human immunodeficiency virus type 1 (HIV-1). To efficiently study transmission mechanisms and prevention strategies, a small animal model permissive for rectal transmission of HIV is mandatory. We tested the susceptibility of RAG2(-/-)gamma(c)(-/-) mice tran... | 18,842,716 |
Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia. | A window of opportunity for immune responses to extinguish human immunodeficiency virus type 1 (HIV-1) exists from the moment of transmission through establishment of the latent pool of HIV-1-infected cells. A critical time to study the initial immune responses to the transmitted/founder virus is the eclipse phase of H... | 18,842,730 |
Illness beliefs about heart disease and adherence to secondary prevention regimens. | We investigated illness beliefs of recently hospitalized patients with coronary artery disease (CAD) and the prospective association between these beliefs and adherence to secondary prevention behaviors. Causal attributions of CAD and their concordance with actual patient risk profiles were also examined. A prospective... | 18,842,739 |
MR imaging of orbital inflammatory syndrome, orbital cellulitis, and orbital lymphoid lesions: the role of diffusion-weighted imaging. | Orbital inflammatory syndrome (OIS) has clinical features that overlap with orbital lymphoid lesions and orbital cellulitis. Prompt diagnosis is needed in all 3 conditions because the management of each one differs greatly. CT and MR imaging, though useful, do not always distinguish among these conditions. The aim of t... | 18,842,758 |
Intracranial internal carotid artery calcifications: association with vascular risk factors and ischemic cerebrovascular disease. | Atherosclerotic calcifications are present not only in the extracranial carotid bifurcation but also in the intracranial part of the internal carotid artery. We assessed the association between intracranial internal carotid artery calcifications and cardiovascular risk factors in patients with ischemic cerebrovascular ... | 18,842,764 |
Home use of vegetable oils, markers of systemic inflammation, and endothelial dysfunction among women. | Most knowledge about adverse health effects of trans fats was mainly derived from studies done in Western populations of European or American origins; few data are available in the understudied region of the Middle East. We assessed the association between consumption of partially hydrogenated vegetable oils (PHVOs) an... | 18,842,776 |
Manipulation of lipid bioaccessibility of almond seeds influences postprandial lipemia in healthy human subjects. | Plant cell walls are known to influence the rate and extent of lipid release from plant food tissues during digestion; however, the effect of cell wall structure on postprandial lipemia is unknown. The objective was to investigate the effects of lipid release (bioaccessibility) on postprandial lipemia by comparing lipi... | 18,842,777 |
FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. | The delta-5 and delta-6 desaturases, encoded by FADS1 and FADS2 genes, are key enzymes in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA). Single-nucleotide polymorphisms (S... | 18,842,780 |
Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs. | Hepatic glucose uptake is enhanced by the portal delivery of glucose, which creates a negative arterioportal substrate gradient. Hepatic amino acid (AA) utilization may be regulated by the same phenomenon, but this has not been proven. We aimed to assess hepatic AA balance and protein synthesis with or without a negati... | 18,842,785 |
No evidence of mass dependency of specific organ metabolic rate in healthy humans. | In humans, resting energy expenditure (REE) can be calculated from organ and tissue masses using constant specific organ metabolic rates. However, interspecies data suggest allometric relations between body mass and organ metabolic rate with higher specific metabolic rates in mammals with a smaller body mass. The objec... | 18,842,787 |
Meta-analysis of the quantity of calcium excretion associated with the net acid excretion of the modern diet under the acid-ash diet hypothesis. | The acid-ash diet hypothesis of osteoporosis suggests that acid from the modern diet causes a demineralization of the skeleton, and mobilized bone calcium is excreted. A systematic approach has not been used to summarize the findings of the numerous studies about the hypothesis. The purpose of this meta-analysis was to... | 18,842,807 |
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. | The vertebrate embryonic vasculature develops from angioblasts, which are specified from mesodermal precursors and develop in close association with blood cells. The signals that regulate embryonic vasculogenesis and angiogenesis are incompletely understood. Here, we show that R-spondin 3 (Rspo3), a member of a novel f... | 18,842,812 |
Mobilisation of Ca2+ stores and flagellar regulation in human sperm by S-nitrosylation: a role for NO synthesised in the female reproductive tract. | Generation of NO by nitric oxide synthase (NOS) is implicated in gamete interaction and fertilisation. Exposure of human spermatozoa to NO donors caused mobilisation of stored Ca(2+) by a mechanism that did not require activation of guanylate cyclase but was mimicked by S-nitroso-glutathione (GSNO; an S-nitrosylating a... | 18,842,814 |
Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor. | The muscle-type nicotinic acetylcholine receptor has two nonidentical binding sites for ligands. The selectivity of acetylcholine and the competitive antagonists (+)-tubocurarine and metocurine for adult mouse receptors is known. Here, we examine the site selectivity for four other competitive antagonists: cisatracuriu... | 18,842,832 |
Leptospira wolffii sp. nov., isolated from a human with suspected leptospirosis in Thailand. | A single Leptospira strain (designated Khorat-H2(T)) was isolated from the urine of an adult male patient with suspected leptospirosis from the province of Nakornrachasima, Thailand. The isolate showed typical Leptospira motility and morphology under dark-field microscopy. Cells were 10-13 mum long and 0.2 mum in diame... | 18,842,846 |
Curtobacterium ginsengisoli sp. nov., isolated from soil of a ginseng field. | A Gram-positive, non-motile, pale-yellow, short rod-shaped bacterium, strain DCY26(T), was isolated from soil of a ginseng field in South Korea and was investigated to determine its taxonomic position. The organism grew optimally at 30-37 degrees C. The G+C content of its DNA was 65.8 mol%. Phylogenetic analysis based ... | 18,842,862 |
Phycicoccus bigeumensis sp. nov., a mesophilic actinobacterium isolated from Bigeum Island, Korea. | An actinomycete strain, designated MSL-03(T), was isolated from a soil sample collected from Bigeum Island in the Republic of Korea. The coccoid cells of the organism were Gram-positive and non-motile and did not form endospores. The colonies were yellow, small, circular with entire margins and contained meso-diaminopi... | 18,842,868 |
Proposed revision of Rule 33c to perpetuate the citation of revived names. | All names published prior to 1980 that were not included in the Approved Lists are available for reuse without reference to their past application. However, the International Code of Nomenclature of Bacteria endorses the revival of disused names in the sense in which they were previously used and provides Rules (28a, 3... | 18,842,877 |
Transformation of a virtual action plan into a motor plan in the premotor cortex. | Before preparing to initiate a forthcoming motion, we often acquire information about the future action without specifying actual motor parameters. The information for planning an action at this conceptual level can be provided with verbal commands or nonverbal signals even before the associated motor targets are visib... | 18,842,888 |
Central contributions to acoustic variation in birdsong. | Birdsong is a learned behavior remarkable for its high degree of stereotypy. Nevertheless, adult birds display substantial rendition-by-rendition variation in the structure of individual song elements or "syllables." Previous work suggests that some of this variation is actively generated by the avian basal ganglia cir... | 18,842,896 |
GABAergic afferents activate both GABAA and GABAB receptors in mouse substantia nigra dopaminergic neurons in vivo. | Most in vivo electrophysiological studies of substantia nigra have used rats. With the recent proliferation of the use of mice for in vitro neurophysiological studies because of the availability of various genetically modified strains to identify the roles of various channels and proteins in neuronal function, it is cr... | 18,842,898 |
Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. | Recent studies suggest that subtype-selective activators of M(1)/M(4) muscarinic acetylcholine receptors (mAChRs) may offer a novel approach for the treatment of psychotic symptoms associated with schizophrenia and Alzheimer's disease. Previously developed muscarinic agonists have provided clinical data in support of t... | 18,842,902 |
Targeting of RGS7/Gbeta5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP. | Complexes of regulator of G-protein signaling (RGS) proteins with G-protein beta5 (Gbeta5) subunits are essential components of signaling pathways that regulate the temporal characteristics of light-evoked responses in vertebrate retinal photoreceptors and ON-bipolar cells. Recent studies have found that RGS/Gbeta5 com... | 18,842,904 |
Etanercept-induced lupus erythematosus presenting as a unilateral pleural effusion. | A 72-year-old man receiving etanercept for the treatment of psoriatic arthritis had an exudative pleural effusion with nonspecific fluid analysis and pleural biopsy findings. He was ultimately found to have drug-induced lupus erythematosus due to the etanercept. The spectrum of autoimmune disease due to the use of tumo... | 18,842,918 |
Anxiety and depression in COPD: current understanding, unanswered questions, and research needs. | Approximately 60 million people in the United States live with one of four chronic conditions: heart disease, diabetes, chronic respiratory disease, and major depression. Anxiety and depression are very common comorbidities in COPD and have significant impact on patients, their families, society, and the course of the ... | 18,842,932 |
Uropathogens and host characteristics. | Uropathogens other than Escherichia coli occur with greater frequency in patients with risk factors for urinary tract infection (UTI). However, little is known about associations between uropathogen species and host characteristics. Three hundred nineteen urine specimens containing a balanced distribution of uropathoge... | 18,842,936 |
Early stages of melody processing: stimulus-sequence and task-dependent neuronal activity in monkey auditory cortical fields A1 and R. | To explore the effects of acoustic and behavioral context on neuronal responses in the core of auditory cortex (fields A1 and R), two monkeys were trained on a go/no-go discrimination task in which they learned to respond selectively to a four-note target (S+) melody and withhold response to a variety of other nontarge... | 18,842,950 |
Differential effects of divalent cations on spontaneous and evoked glycine release from spinal interneurons. | The effects of Ca2+, Sr2+, and Ba2+ on spontaneous and evoked glycinergic inhibitory postsynaptic currents (mIPSCs and eIPSCs) were studied using the "synaptic bouton" preparation of rat spinal neurons and conventional whole cell recording under voltage-clamp conditions. In response to application of Ca2+-free solution... | 18,842,954 |
Balance of increases and decreases in firing rate of the spontaneous activity of basal ganglia high-frequency discharge neurons. | Most neurons in the external and internal segments of the globus pallidus and the substantia nigra pars reticulata (GPe, GPi, and SNr) are characterized by a high-frequency discharge (HFD) rate (50-80 Hz) that, in most GPe neurons, is also interrupted by pauses. Almost all (approximately 90%) of the synaptic inputs to ... | 18,842,958 |
Prescribing quality indicators of type 2 diabetes mellitus ambulatory care. | Existing performance indicators for assessing quality of care in type 2 diabetes mellitus (T2DM) focus mostly on registration of measurements and clinical outcomes, and not on quality of prescribing. To develop a set of valid prescribing quality indicators (PQI) for internal use in T2DM, and assess the operational vali... | 18,842,968 |
Genetic polymorphisms, messenger RNA expression of p53, p21, and CCND1, and possible links with chromosomal aberrations in Chinese vinyl chloride-exposed workers. | This study explores the relationship between genetic polymorphisms of p53, p21, and CCND1, and the susceptibility of chromosomal damage induced by vinyl chloride monomer (CH(2)=CHCl, VCM). Besides gene polymorphisms, we detected the mRNA expression of p53, p21, and CCND1 in VCM-exposed workers and in a control group. O... | 18,842,998 |
Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. | We have completed a single ascending dose clinical study of the proposed chemopreventive agent 3,3'-diindolylmethane (DIM). The study agent was nutritional-grade, absorption-enhanced BioResponse 3,3'-diindolylmethane (BR-DIM). We determined the safety, tolerability, and pharmacokinetics of single doses of BR-DIM in dru... | 18,843,002 |
Comparing the reliability of responses to telephone-administered versus self-administered Web-based surveys in a case-control study of adult malignant brain cancer. | To determine whether a Web-based survey was an acceptable method of data collection for a clinic-based case-control study of adult brain cancer, the authors compared the reliability of paired responses to a main and resurvey for participants completing surveys by telephone (n=74) or self-administered on the Web (n=465)... | 18,843,005 |
Differential suture loading in an experimental rotator cuff repair. | Repairs of large rotator cuff tears often fail to heal. A possible factor in these failures is excessive tension in the repair sutures, causing them to pull through the tendon. Arm positions encountered during early rehabilitation after cuff repair can dramatically increase the relative tension in the different sutures... | 18,843,038 |
Posttranslational regulation of the scaffold for Fe-S cluster biogenesis, Isu. | Isu, the scaffold protein on which Fe-S clusters are built in the mitochondrial matrix, plays a central role in the biogenesis of Fe-S cluster proteins. We report that the reduction in the activity of several components of the cluster biogenesis system, including the specialized Hsp70 Ssq1, causes a 15-20-fold up-regul... | 18,843,040 |
CCAAT/enhancer-binding protein beta promotes osteoblast differentiation by enhancing Runx2 activity with ATF4. | Although CCAAT/enhancer-binding protein beta (C/EBPbeta) is involved in osteocalcin gene expression in osteoblast in vitro, the physiological importance of and molecular mechanisms governing C/EBPbeta in bone formation remain to be elucidated. In particular, it remains unclear whether C/EBPbeta acts as a homodimer or a... | 18,843,047 |
Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells. | The neonatal Fc receptor, FcRn mediates an endocytic salvage pathway that prevents degradation of IgG, thus contributing to the homeostasis of circulating IgG. Based on the low affinity of IgG for FcRn at neutral pH, internalization of IgG by endothelial cells is generally believed to occur via fluid-phase endocytosis.... | 18,843,053 |
Recombinant activated factor VII use in the emergency department. | Recombinant activated factor VII (rFVIIa) has recently gained wide attention as a potent prohaemostatic agent for patients with excessive or life-threatening blood loss. Originally licensed for the treatment of patients with bleeding haemophilia with antibodies to factor VIII or IX, rFVIIa is now being used on an off-l... | 18,843,055 |
Paediatric allergic reactions in the emergency department: a review. | Allergic diseases are increasing in incidence worldwide and large numbers of children are now affected by allergy. Few studies have examined allergic reactions in children, particularly in the emergency department (ED) setting. Primary--to describe the epidemiology of acute paediatric allergic reactions. Secondary--to ... | 18,843,063 |
Hepatitis B vaccine and the risk of CNS inflammatory demyelination in childhood. | The risk of CNS inflammatory demyelination associated with hepatitis B (HB) vaccine is debated, with studies reporting conflicting findings. We conducted a population-based case-control study where the cases were children with a first episode of acute CNS inflammatory demyelination in France (1994-2003). Each case was ... | 18,843,097 |
Novel congenital myopathy locus identified in Native American Indians at 12q13.13-14.1. | Native American myopathy (NAM) is an autosomal recessive congenital myopathy first reported in the Lumbee Indian people. Features of NAM include congenital weakness, cleft palate, ptosis, short stature, and susceptibility to malignant hyperthermia provoked by anesthesia. We identified five individuals with NAM from the... | 18,843,099 |
Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. | The discoidal/fusiform vesicles (DFV) of bladder umbrella cells undergo regulated exocytosis in response to stretch, but little is known about their biogenesis or the molecular machinery that modulates this process. We observed that Rab11a was expressed in umbrella cells (but not Rab11b or Rab25) and was associated wit... | 18,843,107 |
Reconstruction of the human gastrocnemius force-length curve in vivo: part 1-model-based validation of method. | The muscle fiber force-length relationship has been explained in terms of the cross-bridge theory at the sarcomere level. In vivo, for a physiologically realistic range of joint motion, and therefore range of muscle fiber lengths, only part of the force-length curve may be used; that is, the section of the force-length... | 18,843,149 |
Continuous relative phase variability during an exhaustive run in runners with a history of iliotibial band syndrome. | Previous research has proposed that a lack of variability in lower extremity coupling during running is associated with pathology. The purpose of the study was to evaluate lower extremity coupling variability in runners with and without a history of iliotibial band syndrome (ITBS) during an exhaustive run. Sixteen runn... | 18,843,156 |
Determining carotid artery pressure from scaled diameter waveforms: comparison and validation of calibration techniques in 2026 subjects. | Calibrated diameter distension waveforms could provide an alternative for local arterial pressure assessment more widely applicable than applanation tonometry. We compared linearly and exponentially calibrated carotid diameter waveforms to tonometry readings. Local carotid pressures measured by tonometry and diameter w... | 18,843,161 |
ECG scaling properties of cardiac arrhythmias using detrended fluctuation analysis. | We applied detrended fluctuation analysis to characterize at very short time scales during episodes of cardiac arrhythmias the raw electrocardiogram (ECG) waveform, aiming to get a global insight into its dynamical behaviour in patients who experienced sudden death. We found that in 15 recordings involving different ty... | 18,843,162 |
Dynamic measures of regional lung air volume using phase contrast x-ray imaging. | Phase contrast x-ray imaging can provide detailed images of lung morphology with sufficient spatial resolution to observe the terminal airways (alveoli). We demonstrate that quantitative functional and anatomical imaging of lung ventilation can be achieved in vivo using two-dimensional phase contrast x-ray images with ... | 18,843,172 |
Efficacy of ER-alpha polymorphisms and the intrafollicular IGF system for predicting pregnancy in IVF-ET patients. | To evaluate the efficacies of the estrogen receptor-alpha (ER-alpha) gene polymorphisms and of the intrafollicular insulin-like growth factor (IGF) system for predicting pregnancy in in vitro fertilization and embryo transfer (IVF-ET) patients. A total of 96 patients undergoing IVF-ET were included in this study. Genot... | 18,843,190 |
14-3-3 Gamma is required to enforce both the incomplete S phase and G2 DNA damage checkpoints. | Checkpoint pathways inhibit mitotic progression by inducing the phosphorylation of serine 216 in cdc25C resulting in the generation of a 14-3-3 binding site on cdc25C. Two 14-3-3 isoforms, 14-3-3epsilon and 14-3-3gamma form a complex with cdc25C and inhibit cdc25C function. To examine the contribution of 14-3-3gamma to... | 18,843,201 |
IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells. | Global control of mRNA translation plays key roles in cell regulation, including growth, differentiation and apoptosis. Human monocyte-like U937 cells differentiate into macrophage-like cells upon 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, a process which is known to be accompanied with a large decrease in g... | 18,843,202 |
Treatment of a critically ill child with disseminated Candida glabrata with a recombinant human antibody specific for fungal heat shock protein 90 and liposomal amphotericin B, caspofungin, and voriconazole. | To report a case of fungal sepsis treated prospectively with liposomal amphotericin, caspofungin, and a novel monoclonal antibody specific for candidal heat shock protein 90 (Mycograb, Neutec Pharma, Manchester, UK). Case report. Pediatric intensive care unit in a tertiary care children's hospital. A 7-yr-old male with... | 18,843,247 |
Vitamin D levels and patient outcome in chronic kidney disease. | Vitamin D deficiency has been linked to cardiovascular disease and early mortality in patients on hemodialysis; however, it is not known if the same association exists at earlier stages of chronic kidney disease. To determine this we enrolled 168 consecutive new referrals to a chronic kidney disease clinic over a 2 yea... | 18,843,258 |
Asian promise: the state and future of collaborations in neuroscience. | As investment in science and technology continues to grow in Asia, countries such as China, Japan and Singapore are witnessing great improvements in their neuroscience research environments; this is reflected in the opening of new research institutions and in the influx of neuroscientists trained abroad. Collaborative ... | 18,843,270 |
A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice. | Epistatic interactions between the non-autoimmune strains 129 and C57BL/6 (B6), used for generating gene-targeted animals, can induce a lupus-like disease. Genome-wide scan analyses of testcross progeny between these two strains have identified several lupus susceptibility loci, with the strongest linkage to the produc... | 18,843,275 |
The Sp1 transcription factor binds to the G-allele of the -1087 IL-10 gene polymorphism and enhances transcriptional activation. | The objectives of this study were to evaluate the influence of the -1087 single nucleotide polymorphism (SNP) on the gene expression of interleukin (IL)-10 and to identify transcription factors binding to this site in B cells. Using electrophoretic mobility-shift assays and nuclear extract from the DG75 B-cell line, we... | 18,843,277 |
HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma. | Pancreatic ductal adenocarcinoma is a highly aggressive, lethal human malignancy that continues to elude successful treatment. Although most patients present with metastatic disease, the molecular pathways that underlie tumor progression and metastases are poorly understood. The high mobility group A2 (HMGA2) protein i... | 18,843,278 |
Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils. | Carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) is a cell-surface glycoprotein, belonging to the carcinoembryonic antigen family, expressed by human neutrophils, epithelial cells, activated T and NK cells. CEACAM1 is expressed as a cell-surface molecule with different isoforms or can be secreted... | 18,843,289 |
Mitotic Origins of Chromosomal Instability in Colorectal Cancer. | Mitosis is a crucial part of the cell cycle. A successful mitosis requires the proper execution of many complex cellular behaviors. Thus, there are many points at which mitosis may be disrupted. In cancer cells, chronic disruption of mitosis can lead to unequal segregation of chromosomes, a phenomenon known as chromoso... | 18,843,382 |
Use of headspace SPME-GC-MS for the analysis of the volatiles produced by indoor molds grown on different substrates. | An automated headspace solid phase microextraction method followed by GC-MS analysis was used to evaluate and compare the in vitro production of microbial volatile organic compounds (MVOCs) on malt extract agar, plasterboard and wallpaper. Five fungal strains were isolated from the walls of water-damaged houses and ide... | 18,843,388 |
Highly efficient formation of halodiazoacetates and their use in stereoselective synthesis of halocyclopropanes. | Halogenated analogues of ethyl diazoacetate are synthesised by a novel and highly efficient procedure and give halocyclopropanes in good to excellent yields when exposed to a Rh(ii) catalyst in the presence of alkenes. | 18,843,396 |
High yielding selective access to spirocyclopropanated 5-oxopiperazine-2-carboxylates and 1,4-diazepane-2,5-diones from methyl 2-chloro-2-cyclopropylideneacetate. | The 2-spirocyclopropanated methyl 5-oxopiperazine-2-carboxylate and the 3-spirocyclopropanated 6-chloro-1,4-diazepane-2,5-dione could both be prepared at choice in 93 and 88% yield, respectively, from methyl 2-chloro-2-cyclopropylideneacetate () in a sequence of Michael addition of 3-benzyloxypropylamine, peptide coupl... | 18,843,412 |
Stannyl ceramides as efficient acceptors for synthesising beta-galactosyl ceramides. | beta-Galactosyl ceramides have been obtained in excellent yields and stereoselectivities by reacting disarmed glycosyl donors with stannyl ethers. The broad compatibility of stannyl ethers with various leaving group-promoter pairs is demonstrated. | 18,843,414 |
Electronically varied quinazolinaps for asymmetric catalysis. | The synthesis and resolution of electronically varied axially chiral Quinazolinaps is reported. These ligands bear different aryl groups on the donor phosphorus atom and were synthesised as part of our investigations into electronic effects within this ligand class. A diastereomerically pure palladacycle of one ligand ... | 18,843,417 |
Driving behaviour after brain injury: a follow-up of accident rate and driving patterns 6-9 years post-injury. | A follow-up of accident rate and driving patterns of patients 6-9 years after brain injury. Postal questionnaire sent to patients with brain injury who were assessed consecutively in the period 1997-2000 and who were re-issued. A total of 93 persons, 69 men and 24 women, mean age 57 years, average 9 years post-injury, ... | 18,843,425 |
An orthosis and physiotherapy programme for camptocormia: a prospective case study. | Camptocormia, or bent spine syndrome, is an acquired postural disease leading to lumbar kyphosis observed when the patient stands up. Classic orthoses and physiotherapy programmes provide little correction and are often poorly tolerated. The aim of this study was to evaluate the effectiveness and tolerance of a new ort... | 18,843,430 |
Effects of resistance training in combination with coenzyme Q10 supplementation in patients with post-polio: a pilot study. | Coenzyme Q10 supplementation leads to increased muscle metabolism in patients with post-polio syndrome. The aim of this study was to investigate the effect of resistance training in combination with oral supplementation with coenzyme Q10 in patients with post-polio syndrome regarding muscle strength and endurance as we... | 18,843,432 |
Laparoscopic-assisted combined colon and liver resection for primary colorectal cancer with synchronous liver metastases: initial experience. | Laparoscopic approaches have become increasingly used in selected patients with either colorectal or liver cancer. However, the feasibility of laparoscopic-assisted combined colon and liver resection in primary colorectal cancer with synchronous liver metastases remains unknown. The aim of the present study was to dete... | 18,843,442 |
Modified technique of pancreaticojejunal anastomosis with invagination following pancreaticoduodenectomy: a cohort study. | Leakage from pancreatic anastomoses remains the single most important morbidity after pancreaticoduodenectomy and contributes to prolonged hospitalization and mortality. This observational cohort study reported the surgical outcome of a modified invagination technique of pancreaticojejunostomy after pancreaticoduodenec... | 18,843,443 |
Advances in amino acid analysis. | Amino acids are important targets for metabolic profiling. For decades, amino acid analysis has been accomplished by either cation-exchange or reversed-phase liquid chromatography coupled to UV absorbance or fluorescence detection of pre-column or post-column-derivatized amino acids. Recent years have seen great progre... | 18,843,484 |
Determination of biogenic amines in food samples using derivatization followed by liquid chromatography/mass spectrometry. | A liquid chromatography (LC)/mass spectrometry method was developed for the determination of selected biogenic amines in various fish and other food samples. It is based on a precolumn derivatization of the amines with succinimidylferrocenyl propionate under formation of the respective amides and their reversed-phase l... | 18,843,485 |
A systematic review on the effect of bevacizumab in exudative age-related macular degeneration. | To provide evidence for the effect of bevacizumab on visual acuity (VA) and central retinal thickness (CRT) in exudative age-related macular degeneration A systematic review of all articles of bevacizumab for exudative AMD was conducted. Articles published up to March 2008 were identified in Medline, Embase, the Cochra... | 18,843,500 |
Mechanical-statistical modeling in ecology: from outbreak detections to pest dynamics. | Knowledge about large-scale and long-term dynamics of (natural) populations is required to assess the efficiency of control strategies, the potential for long-term persistence, and the adaptability to global changes such as habitat fragmentation and global warming. For most natural populations, such as pest populations... | 18,843,520 |
HIV/AIDS/STD/HCV, coinfection, seroprevalence and education in severe mental illness: health education pilot. | HIV/AIDS among the severely mentally ill (SMI) population exceeds the held belief that man to man contact is the leading type of, rate of transmission and infection placing an emphasis on high risk behavior management, education and testing as key in reducing the epidemic in psychiatric facility inpatient/outpatient po... | 18,843,534 |
Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys. | The chaperone protein heat shock protein (HSP) 70 has been shown to protect against obesity-associated insulin resistance. Induction of HSPs is thus considered an exciting therapeutic strategy for diabetes (DM). The aims of this study were to (1) determine HSP levels in plasma, hepatic, and pancreatic tissues of type 2... | 18,843,550 |
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