title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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The potential of nano-structured silicon oxide type coatings deposited by PACVD for control of aquatic biofouling. | SiO(x)-like coatings were deposited on glass slides from a hexamethylsiloxane precursor by plasma-assisted CVD (PACVD). Surface energies (23.1-45.7 mJ m(-1)) were correlated with the degree of surface oxidation and hydrocarbon contents. Tapping mode AFM revealed a range of surface topologies with Ra values 1.55-3.16 nm... | 18,855,197 |
Prevalence and risk factors of nasal colonization with Staphylococcus aureus - association with HIV infection in older patients. | Nasal S. aureus colonization was detected in 62/127 patients (49%) at a German infectious diseases clinic; MRSA colonization was infrequent at 2.4%. Male gender (OR=2.71, p=0.04), antimicrobial therapy in hospitalized patients (OR=20.1, p=0.02), and HIV infection in patients>42 y of age (OR=7.74, p=0.02) were indepe... | 18,855,226 |
Assessing change in clinical teaching skills: are we up for the challenge? | The faculty development community has been challenged to more rigorously assess program impact and move beyond traditional outcomes of knowledge tests and self ratings. The purpose was to (a) assess our ability to measure supervisors' feedback skills as demonstrated in a clinical setting and (b) compare the results wit... | 18,855,231 |
Molecular cloning and expression analysis of CD82 in pig. | CD82, which was originally referred to as KAI1 (kangai 1), is a member of the tetraspanin protein family, which contains four transmembrane domains. CD82 is implicated in a variety of biological processes, including apoptosis, cell adhesion, and cell migration. In this study, the full-length cDNA of pig CD82 was cloned... | 18,855,249 |
Vascular endothelial growth factor attenuates Nomega-nitro-L-arginine methyl ester-induced preeclampsia-like manifestations in rats. | To verify the hypothesis that vascular endothelial growth factor (VEGF) attenuates Nomega-Nitro-L-arginine Methyl Ester (L-NAME)-induced preeclampsia-like manifestations in rats. Forty pregnant Wistar rats were randomly divided into four groups: control, preeclampsia model, VEGF treatment, and VEGF prophylactic. On day... | 18,855,264 |
[Cost-efficacy analysis of fixed combinations of prostaglandin/prostamide for treating glaucoma]. | To assess the cost-efficacy of three fixed-combination glaucoma treatments currently available in Spain [bimatoprost with timolol (BT)- Ganfort, latanoprost with timolol (LT)- Xalacom, and travoprost with timolol (TT)- DuoTrav]. Because no studies are available that give a direct comparison of these drugs, a systematic... | 18,855,279 |
[Optical coherence tomography study in tamoxifen maculopathy]. | We describe the case of a patient who presented with progressive and bilateral loss of vision. She had been treated with tamoxifen for 13 years. We performed fluorescein angiography and optical coherence tomography in order to study the macula. Loss of visual acuity related to tamoxifen maculopathy may be caused either... | 18,855,282 |
[Intracranial hypertension and cranial sinus stenosis]. | Craneal sinuses stenosis can appear in patients with idiopathic intracranial hypertension. Neuroimaging techniques revealed a right transverse sinus stenosis. As the pressure gradient between both sides of the stenosis was small and response to conservative treatment good, angioplasty was not indicated. Lateral sinus s... | 18,855,283 |
Pre-coronal, paramedian minicraniotomy: a minimal access approach for microsurgical, transcallosal, transforaminal removal of colloid cysts of the third ventricle. | Microsurgical excision of colloid cysts of the third ventricle is accomplished along the transcallosal or the transfrontal routes. In the transcallosal approach, venous tributaries of the superior sagittal sinus can often act as an impediment to entry into the interhemispheric fissure for accessing the corpus callosum.... | 18,855,287 |
Minimally invasive vertebroplasty in the treatment of pain induced by spinal metastatic tumor. | Spinal metastatic tumor is a common problem and represents a challenging problem in oncology practice. Patients with osteolytic metastases often suffer from intractable local and/or radicular pain. Percutaneous vertebroplasty is a minimally invasive, radiologically guided procedure whereby bone cement is injected into ... | 18,855,293 |
De novo sequencing of peptides secreted by the skin glands of the Caucasian Green Frog Rana ridibunda. | Amphibian skin glands are known to secrete various types of bioactive peptides. The array of these peptides is specific for every frog species. The present research deals with the identification of peptides isolated from the skin secretion of the Marsh frog R. ridibunda inhabiting the Kolkhida Canyon of the Caucasian r... | 18,855,342 |
Ionization energies of the nucleotides. | The vertical ionization energies of the four nucleotides have been computed. Geometries have been chosen to mimic orientations as they appear in B-DNA. The negative charge on the phosphate was neutralized by protonation, and also by the inclusion of counterions. Calculations have been performed with electron propagator... | 18,855,364 |
An arene-stabilized cobalt(I) aryl: reactions with CO and NO. | The half-sandwich cobalt(I) complex (eta (6)-C 7H 8)CoAr*-3,5- ( i )Pr 2 (Ar*-3,5- ( i )Pr 2 = -C 6H-2,6-(C 6H 2-2,4,6- ( i )Pr 3) 2-3,5- ( i )Pr 2) was synthesized by reduction of [3,5- ( i )Pr 2Ar*Co(mu-Cl)] 2 in toluene. It reacts with CO or NO to afford the unusual complexes [3,5- ( i )Pr 2Ar*C(O)Co(CO)] or [3,5- (... | 18,855,383 |
Identification of conical structures in small aluminum oxide clusters: infrared spectroscopy of (Al2O3)1-4(AlO)+. | The vibrational spectroscopy of the electronically closed-shell (Al 2O 3) n (AlO) (+) cations with n = 1-4 is studied in the 530-1200 cm (-1) range by infrared predissociation spectroscopy of the corresponding ion-He atom complexes in combination with quantum chemical calculations. In all cases we find, assisted by a g... | 18,855,393 |
Selective stabilization of natively folded RNA structure by DNA constraints. | Learning how native RNA conformations can be stabilized relative to unfolded states is an important objective, for both understanding natural RNAs and improving the design of artificial functional RNAs. Here we show that covalently attached double-stranded DNA constraints (ca. 14 base pairs in length) can significantly... | 18,855,395 |
A new one-pot, four-component synthesis of 1,2-amino alcohols: TiCl3/t-BuOOH-mediated radical hydroxymethylation of imines. | An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl3/t-BuOOH system to afford 1,2-amino alcohols in fair to excellent yields. | 18,855,404 |
Synergistic effects on enantioselectivity of zwitterionic chiral stationary phases for separations of chiral acids, bases, and amino acids by HPLC. | In an attempt to overcome the limited applicability scope of earlier proposed Cinchona alkaloid-based chiral weak anion exchangers (WAX) and recently reported aminosulfonic acid-based chiral strong cation exchangers (SCX), which are conceptionally restricted to oppositely charged solutes, their individual chiral select... | 18,855,417 |
Off-line coupling of capillary electrophoresis to substrate-assisted laser desorption inductively coupled plasma mass spectrometry. | A novel off-line coupling of capillary electrophoresis (CE) and inductively coupled plasma mass spectrometry (ICPMS) is reported here. The coupling interface is based on the connection of a separation capillary to a deposition capillary via a liquid junction maintaining high separation efficiency and sample utilization... | 18,855,419 |
Kinetic and spectroscopic analysis of the catalytic role of H79 in the methionine aminopeptidase from Escherichia coli. | To gain insight into the role of the strictly conserved histidine residue, H79, in the reaction mechanism of the methionyl aminopeptidase from Escherichia coli ( EcMetAP-I), the H79A mutated enzyme was prepared. Co(II)-loaded H79A exhibits an overall >7000-fold decrease in specific activity. The almost complete loss... | 18,855,426 |
Enzyme-catalyzed formation and structure characteristics of a protein-based hydrogel. | A protein-based hydrogel with tunable gelation time and mechanical strength was obtained by the hydrogelation of soy protein isolate (SPI) in the presence of microbial transglutaminase (MTGase). In order to control the gelation process and understand the relationship between the property and network structure of the fo... | 18,855,437 |
Extensional properties of hydroxypropyl ether guar gum solutions. | The extensional properties of 2-hydroxypropyl ether guar gum solutions were investigated using a capillary breakup extensional rheometer (CaBER). Optimization of the geometric parameters of this device allowed for the measurement of the characteristic relaxation times and the apparent extensional viscosities of a serie... | 18,855,439 |
Catalytic asymmetric intramolecular hydroamination of alkynes in the presence of a catalyst system consisting of Pd(0)-methyl Norphos (or tolyl Renorphos)-benzoic acid. | Enantiomerically pure methyl Norphos (A), tolyl Norphos (B), CF(3) Norphos (C), methyl Renorphos (D), and tolyl Renorphos (E) were synthesized and used as chiral bisphosphine ligands for the catalyst system, Pd(2)(dba)(3) x CHCl(3)/PhCOOH, in an intramolecular hydroamination of aminoalkynes 15. Among the Norphos series... | 18,855,453 |
A model for self-diffusion of guanidinium-based ionic liquids: a molecular simulation study. | We propose a novel self-diffusion model for ionic liquids on an atomic level of detail. The model is derived from molecular dynamics simulations of guanidinium-based ionic liquids (GILs) as a model case. The simulations are based on an empirical molecular mechanical force field, which has been developed in our precedin... | 18,855,466 |
Change in relationship quality for partners from lesbian, gay male, and heterosexual couples. | Growth curves for relationship quality over the first 10 years of cohabitation, controlling for separation, were estimated on the basis of survey data obtained over part or all of this time interval. Participants were both partners from 95 lesbian, 92 gay male, and 226 heterosexual couples living without children, and ... | 18,855,506 |
Pharmacogenetics of apolipoprotein E gene during lipid-lowering therapy: lipid levels and prevention of coronary heart disease. | A non-optimal plasma concentration of lipids is among the major modifiable risk factors of atherosclerosis. Therefore, the prevention of cardiovascular disease by means of lipid-lowering therapy with statins and other agents is of great importance for patient groups where a lifestyle change, for example, diet modificat... | 18,855,536 |
A topological approach to chemical organizations. | Large chemical reaction networks often exhibit distinctive features that can be interpreted as higher-level structures. Prime examples are metabolic pathways in a biochemical context. We review mathematical approaches that exploit the stoichiometric structure, which can be seen as a particular directed hypergraph, to d... | 18,855,563 |
Dimeric approaches to anti-cancer chemotherapeutics. | Numerous proteins responsible for cell proliferation and differentiation exist either as hetero or homodimers or become activated through dimerization as a key step in their respective signaling cascade. Many of these proteins have been identified as major components in oncogenic signaling pathways and have become popu... | 18,855,582 |
Mitochondria, mitochondrial DNA and Alzheimer's disease. What comes first? | To date, the beta amyloid (Abeta) cascade hypothesis remains the main pathogenetic model of Alzheimer's disease (AD), but its role in the majority of sporadic AD cases is unclear. The mitochondria play central role in the bioenergetics of the cell and apoptotic cell death. In the past 20 years research has been directe... | 18,855,587 |
CD47 in the immune response: role of thrombospondin and SIRP-alpha reverse signaling. | The past decades have been marked by spectacular progress towards understanding how dendritic cells (DCs) interact with T cells to elicit protective immune responses to fight infectious diseases and cancer. DCs that are lying at the interface between innate and adaptive immunity, are educated in peripheral tissues prio... | 18,855,618 |
The role of cartilage oligomeric matrix protein (COMP) in skeletal disease. | Cartilage oligomeric matrix protein is a non-collagenous extracellular matrix protein expressed primarily in cartilage, ligament, and tendon. Cartilage oligomeric matrix protein has been studied extensively because mutations in the gene cause two skeletal dysplasias, pseudoachondroplasia and multiple epiphyseal dysplas... | 18,855,621 |
Physicochemical parameters of non-viral vectors that govern transfection efficiency. | Gene therapy is based on the vectorization of nucleic acids to target cells and their subsequent expression. Cationic lipids and polymers are the most widely used vectors for the delivery of DNA into cultured cells. Nowadays, numerous reagents made of these cationic molecules are commercially available and used by rese... | 18,855,629 |
Clopidogrel and aspirin in cardiovascular medicine: responders or not--current best available evidence. | Dual antiplatelet therapy represents an important advance for patients with established coronary artery disease. It is an important strategy for patients with acute coronary syndromes and those undergoing percutaneous transcatheter coronary interventions. Clopidogrel effectively inhibits ADP-induced platelet activation... | 18,855,644 |
HHV-6 is frequently detected in dried cord blood spots from babies born to HIV-positive mothers. | Intrauterine transmission of HHV-6 is well established in immunocompetent women while few data are available on infections in babies born to HIV-positive mothers. To assess the rate of HHV-6 vertical transmission in comparison to CMV, we analyzed cord blood spots dried on cards (Dried Blood Spots, DBS) collected during... | 18,855,654 |
Better CD4+ T cell recovery in Brazilian HIV-infected individuals under HAART due to cumulative carriage of SDF-1-3'A, CCR2-V64I, CCR5-D32 and CCR5-promoter 59029A/G polymorphisms. | Polymorphisms of chemokines and chemokine-receptors genes have been shown to influence the rate of progression to AIDS; however, their influence on response to HAART remains unclear. We investigated the frequency of the SDF-1-3'A, CCR2-64I, CCR5-D32 and CCR5-Promoter-59029-A/G polymorphisms in Brazilian HIV-1-infected ... | 18,855,658 |
Cytochrome P450-activated prodrugs: targeted drug delivery. | Cytochrome P450 (CYP) enzymes are a superfamily of heme containing proteins that catalyze xenobiotic metabolism phase I reactions. Oxidation reactions are the most common CYP-catalyzed reactions for both endogenous substrates and exogenous compounds, including drugs, although CYP enzymes are capable also to catalyze re... | 18,855,665 |
The cell cycle molecules behind neurodegeneration in Alzheimer's disease: perspectives for drug development. | Alzheimer's disease (AD), the leading cause of senile dementia, has become a considerable social and economical problem. Current AD therapeutics provide mainly symptomatic short-term benefit, rather than targeting disease mechanisms. The hallmarks for AD are beta-amyloid plaques, neurofibrillary tangles, and regionaliz... | 18,855,671 |
Strategy for a genetic assessment of antipsychotic and antidepressant-related proarrhythmia. | Antidepressants and antipsychotics may affect several ion channels involved in the control of cardiac action potential and be proarrhythmic. In this field, accurate understanding of genetics, which per se is a non-controllable risk factor, may help clinicians to prevent life-threatening side effects. So far, a number o... | 18,855,674 |
Screening aortic drug treatments through arterial compliance measurements. | Abdominal aortic aneurysm (AAA) is a common and deadly problem. The aortic diameter increases in association with a complex remodeling process that includes changes in the structure and content of key proteins, elastin and collagen. As these changes occur, the tissue mechanical properties also change. The natural histo... | 18,855,713 |
The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention. | Essential hypertension is an insulin resistant state. Early insulin signaling steps are impaired in essential hypertension and a large body of data suggests that there is a crosstalk at multiple levels between the signal transduction pathways that mediate insulin and angiotensin II actions. At the extracellular level t... | 18,855,718 |
Occurrence and clinical impact of microembolic signals (MES) in patients with chronic cardiac diseases and atheroaortic plaques--a systematic review. | In various cardiac diseases, thrombembolism constitutes a major risk, and in these patients clinically silent microembolic signals (MES) are detectable within the transcranial Doppler frequency spectrum (TCD) of the major brain arteries. MES are already an accepted surrogate parameter of the future risk of stroke in pa... | 18,855,720 |
Chemistry and pharmacology of collinin, active principle of Zanthoxylum spp. | Collinin is a geranyloxycoumarins isolated in small amounts from plants of the Rutaceae family. Synthetic schemes were recently developed allowing to handle collinin in sufficient quantities to put in evidence valuable biological effects. The aim of this review is to examine the phytochemical and pharmacological proper... | 18,855,734 |
Protein-based voltammetric biosensors fabricated with nanomaterials. | Protein-based voltammetric biosensors are sensors based on the electric communication between proteins and electrodes. Recently, more and more nanomaterials are utilized to assist the fabrication of such kind of biosensors. In this review, we mainly detail the biosensors constructed with different kinds of nanomaterial... | 18,855,746 |
Classification of amine type G-protein coupled receptors with feature selection. | G-protein coupled receptors (GPCRs) are involved in various physiological processes. Therefore, classification of amine type GPCRs is important for proper understanding of their functions. Though some effective methods have been developed, it still remains unknown how many and which features are essential for this task... | 18,855,757 |
From the bakery to the brain business: developing inducible yeast models of human neurodegenerative disorders. | In the last decade, the budding yeast Saccharomyces cerevisiae has been used as a model system to study the mechanisms of the human aging process and of age-associated neurodegenerative disorders such as Parkinson's, Huntington's, Alzheimer's, and amyotrophic lateral sclerosis. S. cerevisiae is a facultative aerobic, u... | 18,855,765 |
Generation of a tightly regulated all-cis beta cell-specific tetracycline-inducible vector. | Ability to induce protein expression at will in a cell is a powerful strategy used by scientists to better understand the function of a protein of interest. Various inducible systems have been designed in eukaryotic cells to achieve this goal. Most of them rely on two distinct vectors, one encoding a protein that can r... | 18,855,768 |
Evaluating statistics in clinical trials: making the unintelligible intelligible. | Medical practitioners should be familiar with the basic principles of statistical testing and analysis, as the critical evaluation of clinical trials is an essential component to the effective practise of evidence-based medicine. Practitioners also need to be able to identify unethical trial design. The aim of this rev... | 18,855,776 |
Treatment of lentigo maligna with total circumferential margin control using vertical and horizontal permanent sections: a retrospective study. | This retrospective study assesses the long-term cure rate for the treatment of lentigo maligna using total circumferential margin control with vertical and horizontal permanent sections using life-table analysis. A cohort of 31 patients in Sydney with lentigo maligna treated with total circumferential margin control wi... | 18,855,780 |
Annular lesions in Kawasaki disease: a cause of confusion. | We present three cases of Kawasaki disease in which an annular eruption was the predominant cutaneous finding. The provisional diagnosis was Stevens-Johnson syndrome. However, the annular lesions were not typical of Stevens-Johnson syndrome: the lips were crusted without mucosal ulceration and the conjunctivitis was no... | 18,855,782 |
Hyperpigmentation, nail dystrophy and alopecia with generalised intestinal polyposis: Cronkhite-Canada syndrome. | A 62-year-old Malaysian woman presented with a constellation of skin signs including alopecia, hyperpigmentation and nail dystrophy. On questioning, a history of diarrhoea, taste disturbance and weight loss was found. The onset of these changes coincided with the administration of thyroxine prescribed for a benign mult... | 18,855,786 |
Stress, alcohol and drug interaction: an update of human research. | A challenging question that continues unanswered in the field of addiction is why some individuals are more vulnerable to substance use disorders than others. Numerous risk factors for alcohol and other drugs of abuse, including exposure to various forms of stress, have been identified in clinical studies. However, the... | 18,855,803 |
Guidelines for research on drugged driving. | A major problem in assessing the true public health impact of drug-use on driving and overall traffic safety is that the variables being measured across studies vary significantly. In studies reported in a growing global literature, basic parameters assessed, analytical techniques and drugs tested are simply not compar... | 18,855,814 |
Pulmonary mucormycosis with cervical lymph node involvement in a patient with acute myeloid leukaemia: a case report. | Here we describe a rare case of pulmonary mucormycosis and simultaneous cervical lymphadenitis in a patient with acute myeloid leukaemia. The patient was successfully treated with liposomal amphotericin B. The diagnosis of Mucor is very difficult, especially in severely immunocompromised patients. This report seems to ... | 18,855,847 |
Epithelial stem cells in corneal regeneration and epidermal gene therapy. | Regenerative medicine refers to innovative therapies aimed at the permanent restoration of diseased tissues and organs. Regeneration of self-renewing tissues requires specific adult stem cells, which need to be genetically modified to correct inherited genetic diseases. Cultures of epithelial stem cells permanently res... | 18,855,878 |
BAL in the diagnosis of smoking-related interstitial lung diseases: review of literature and analysis of our experience. | The group of interstitial lung diseases (ILDs) is formed by respiratory tract disorders, whose aetiology is unknown in the majority of cases, the clinical course differs and the prognosis is generally serious. Some of the ILDs have a potential relation to tobacco smoking and are known as smoking-related ILDs (sr-ILD). ... | 18,855,907 |
Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption. | The small intestine poses a major barrier to the efficient absorption of orally administered therapeutics. Intestinal epithelial cells are an extremely important site for extrahepatic clearance, primarily due to prominent P-glycoprotein-mediated active efflux and the presence of cytochrome P450s. We describe a physiolo... | 18,855,913 |
Extended testing across, not within, tasks raises diagnostic accuracy of smell testing in Parkinson's disease. | The aim of this study was to determine whether extended olfactory testing within a single olfactory task and/or across olfactory tasks increases diagnostic accuracy of olfactory testing in Parkinson's disease (PD). Olfactory function was assessed using an extended version of the "Sniffin' Sticks", comprising 32-item od... | 18,855,928 |
Mechanisms underlying Li+ effects in glutamatergic and GABAergic neurotransmissions in the adult rat brain and in primary cultures of neural cells as revealed by 13C NMR. | We investigated by (13)C nuclear magnetic resonance (NMR) the mechanisms underlying Li(+) effects on glutamatergic and GABAergic neurotransmission systems in the adult rat brain and in primary cultures of cortical neurons and astrocytes during the metabolism of (1-(13)C) glucose or (2-(13)C) acetate. Adult male rats re... | 18,855,940 |
Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect. | Fluoxetine is a selective serotonin reuptake inhibitor that is widely used in the treatment of major depression including after stroke. In this study, we tested whether fluoxetine protects neuronal death in a rat cerebral ischemia model of middle cerebral artery occlusion (MCAO). The administration of fluoxetine intrav... | 18,855,941 |
Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line. | A major concern regarding the chronic administration of antiretroviral drugs is the potential for induction of drug efflux transporter expression (i.e., P-glycoprotein, P-gp) at tissue sites that can significantly affect drug distribution and treatment efficacy. Previous data have shown that the inductive effect of hum... | 18,855,943 |
A facile route for regioselective conjugation of organo-soluble polymers onto chitosan. | A facile route is described for the regioselective conjugation of organo-soluble polymers onto chitosan under very mild conditions, using SCC as intermediates. SCC could be prepared simply by mixing chitosan acidic aqueous solution with SDS. PEG or PCL were then grafted to SCC using the NHS/DCC coupling method. In addi... | 18,855,945 |
Suppression of gastric cancer growth by baculovirus vector-mediated transfer of normal epithelial cell specific-1 gene. | To study the inhibitory effect of baculovirus-mediated normal epithelial cell specific-1 (NES1) gene therapy on gastric cancer (GC) in vitro and in vivo. We first constructed recombinant baculovirus vectors and then transfected them into gastric cancer cells (SGC-7901). Efficiency of the baculovirus for gene transfer i... | 18,855,978 |
Health improvement through dietary management of type 2 diabetes. | Diabetes is found to be one of the fastest growing chronic diseases with a high incidence among older people, and in residential care homes the prevalence of diabetes can be as high as 25% percent. A range of complications can develop following the onset of the disease. The prevention of these complications is in line ... | 18,856,019 |
[Diagnostic image (390). A man with hepatic and mesenterial gas]. | A 78-year-old man presented with pneumatosis intestinalis and hepatic portal venous gas. | 18,856,028 |
[Differences between hospitals in outcome after a stroke are only partially explained by differences in the quality of care]. | To determine the extent to which the outcome of stroke patients stroke is correlated with patient characteristics and care process parameters, and to determine whether outcome measures can be used to measure the quality of hospital care provided for these patients. Descriptive cohort study. At 10 hospitals in the Nethe... | 18,856,030 |
Prevalence of quinolone-resistant urinary tract infections in Comanche County Memorial Hospital. | Urinary tract infection (UTI) is not only a common outpatient but also the most frequently occurring nosocomial infection. The most common causative organisms of UTI remain Escherichia coli, nosocomial gram-negative bacilli, enteroccoci and candida. Many physicians use quinolones as the agent of choice for treatment of... | 18,856,050 |
[Association between the Val66Met polymorphism of brain-derived neurotrophic factor gene and schizophrenia in Russians]. | Recent studies have demonstrated a role of the brain-derived neurotrophic factor (BDNF) in schizophrenia. An association between the Val66Met BDNF polymorphism has been reported but the results of different studies are inconsistent. An aim of the present article is to study the allele and genotype distribution in patie... | 18,856,059 |
[Increase of BIRC5 gene expression in non-small cell lung cancer and esophageal squamous cell carcinoma does not correlate with expression of genes SMAC/DIABLO and PML encoding its inhibitors]. | Survivin (BIRC5) is one of the members of IAP-family apoptosis inhibitors. The BIRCS gene is expressed in most human embryonic tissues and malignant tumors but not in normal differentiated tissues of adult human. It was suggested that BIRC5 proteins inhibit apoptosis and play an essential role in tumorigenesis, makings... | 18,856,066 |
[Intramolecular G-quadruplexes from microsatellite d(GT)12 sequence in the presence of K+]. | Polymorphic d(GT)n microsatellite sequences are known to drastically affect genes expression. By use of CD spectroscopy, UV melting, fluorescence polarization of EtBr probe and FRET, we detected formation of a new fold with three G-quartets by d(GT)12 oligonucleotide in 0.01 M Na phosphate buffer, pH 8.0, in the presen... | 18,856,070 |
Pharmacotherapy of hepatitis B infection: a brief review. | Chronic infection with hepatitis B virus can lead to liver disease, cirrhosis, and hepatocellular carcinoma. Treatment options include interferons and antiviral drugs. The interferons have immunomodulatory, antiproliferative, and antiviral effects. Nucleoside analogs, such as entecavir, lamivudine and telbivudine, and ... | 18,856,082 |
[Risk factors for non-compliance to treatment with highly effective antiretroviral therapy]. | The purpose of the study was: to measure the prevalence of non-compliance to highly active antiretroviral therapy (HAART) by AIDS patients; to identify whether some of the factors listed in health literature were associated with non-compliance; to establish the predictive values of non-compliance to HAART-related facto... | 18,856,116 |
[Cardiopulmonary resuscitation with semi-automated external defibrillator: assessment of the teaching-learning process]. | Studies demonstrate that, for every minute delayed on defibrillating a heart arrest patient, survival chances decrease by 10%, and that the same chances of survival are 98% effective when it is employed within 30 seconds. While attending a heart arrest patient, it is crucial that the use of external semi-automated defi... | 18,856,122 |
Acute nursing care and management of patients with sickle cell. | The information provided in this article has been developed to coincide with the recent findings from a National Confidential Enquiry into Patient Outcome and Death (2008) report, 'A Sickle Cell Crisis', which calls for nurses to learn more about the disorder in order to better support patients in their care. This arti... | 18,856,142 |
Pressure ulcer prevention and pressure-relieving surfaces. | Although rarely subject to media attention, political interest or research funding, pressure ulcers, and their almost inevitable increase in incidence, detrimentally affect the quality of life of thousands of patients, both in the hospital and community setting. In addition, the costs to the NHS of pressure-ulcer-relat... | 18,856,145 |
Iatrogenic lip and facial burns caused by an overheated surgical instrument. | An unusual case of an iatrogenic superficial burn of the lip and face during third molar surgery is presented. The burn was caused by a heated surgical instrument after sterilization. Although completely healed within three weeks, the burn had a negative influence on the patient-doctor trust. The surgical team must avo... | 18,856,171 |
Finger and toe temperatures on exposure to cold water and cold air. | Subjects with a weak cold-induced vasodilatation response (CIVD) to experimental cold-water immersion of the fingers in a laboratory setting have been shown to have a higher risk for local cold injuries when exposed to cold in real life. Most of the cold injuries in real life, however, occur in the foot in cold air rat... | 18,856,183 |
Lilienthal's fatal glider crash in 1896: evidence regarding the cause of death. | Otto Lilienthal's pioneering work on gliders helped form the basis for development of powered aircraft. His death following a glider crash in 1896 was officially ascribed to fracture of the cervical spine. However, the clinical details assembled here make it more likely that he died from head trauma with resulting comp... | 18,856,192 |
Adaptation of the cardiovascular system to postinfarction cardiosclerosis in rats with congenital adrenoreactivity of the myocardium. | Three months after myocardial infarction the severity of heart failure and size of postinfarction scars in August rats with inherently reduced adrenoreactivity of the myocardium were similar to those in Wistar rats. The mortality rate in August rats was 2.5-fold lower than in Wistar rats. During the postinfarction peri... | 18,856,199 |
Effect of silimarin, succinic acid, and their combination on bioenergetics of the brain in experimental encephalopathy. | In rats with experimental encephalopathy caused by intoxication with 4-pentenoic acid inhibiting beta-oxidation of medium- and long-chain fatty acids, hepatoprotector silimarin inhibited LPO, prevented deenergization and maintained high respiratory activity of brain mitochondria, and increased the rate and coupling of ... | 18,856,206 |
Comparison of the toric implantable collamer lens and custom ablation LASIK for myopic astigmatism. | To compare the results of wavefront-guided custom LASIK and the Toric Implantable Collamer Lens (TICL) in the correction of myopic astigmatism. This observational, non-randomized study compared clinical efficacy results from the TICL's US Food and Drug Administration Clinical Trial and published Summaries of Safety and... | 18,856,230 |
Phakic toric Implantable Collamer Lens implantation for the correction of high myopic astigmatism in eyes with keratoconus. | To present two patients in whom phakic toric Implantable Collamer Lenses (toric ICL, STAAR Surgical) have been effective for the correction of high myopic astigmatism with stable keratoconus. Both patients had a history of contact lens intolerance, and refraction and corneal topography were stable for 3 to 4 years. Pre... | 18,856,240 |
A study of the relationship between the fever caused by bacterial pyrogens and the fever accompanying acute infections. | The relationship between the fever of acute infection and that following injection of bacterial pyrogen was studied by administering pyrogens to animals convalescent from acute infections. Rabbits surviving dermal pneumococcal infections or peritonitis due to Escherichia coli were given intravenous injections of typhoi... | 18,881,485 |
Production of atheromatosis in the aorta of the bird by the administration of diethylstilbestrol. | A new experimental procedure for the production of arteriosclerosis in the bird is described. The subcutaneous implantation of diethylstilbestrol by means of which a sustained increase in the concentration of cholesterol, phospholipid, and neutral fat can be readily established, is shown to induce atherosclerosis of th... | 18,881,496 |
Hypertension in the systemic blood of animals with experimental renal hypertension. | 1. A method has been developed which makes possible the demonstration of a pressor substance in the circulating systemic blood of dogs with experimental renal hypertension. 2. After the intravenous injection of renin into normal dogs, it was possible to detect a pressor substance formed in the systemic blood. After the... | 18,884,899 |
Regulatory mechanisms of cellular respiration; the role of cell membranes; uranium inhibition of cellular respiration. | Uranium as UO(2)(NO(3))(2) combines reversibly with proteins. The degree of dissociation of this combination depends, among other factors, on the H(+) concentration. At pH 7.3 the U-albumin complex was easily dissociated on addition of citrate, while at pH 3.8 it was not. Uranium inhibited reversibly a number of enzyme... | 18,891,143 |
Regulatory mechanisms of cellular respiration; the role of soluble sulfhydryl groups as shown by the effect of sulfhydryl reagents on the respiration of sea urchin sperm. | Oxidizing agents of sulfhydryl groups such as iodosobenzoate, alkylating agents such as iodoacetamide, and mercaptide-forming agents such as cadmium chloride, mercuric chloride, p-chloromercuribenzoate, sodium arsenite, and p-carboxyphenylarsine oxide, added in small concentrations to a suspension of sea urchin sperm p... | 18,891,144 |
Phage formation in Staphylococcus muscae cultures; the competition between host and virus for a nutrient. | 1. Experiments carried out in Fildes' synthetic medium show that there is a competition between the host and virus for a substance present in acid-hydrolyzed casein. This substance appears to be essential for the multiplication of the virus but not for the host. | 18,891,147 |
Immunochemical studies on blood groups; the cross reaction between type XIV antipneumococcal horse serum and purified blood group A, B, and O substances from hog and human sources. | Purified blood group A, B, and O substances from hog and human sources precipitate with Type XIV antipneumococcal horse serum and provide an explanation for the observation that Type XIV antibody agglutinates human erythrocytes of all four major blood groups. Individual preparations of A substance or O substance from e... | 18,904,215 |
Food protein effect on plasma specific gravity, plasma protein, and hematocrit value. | When the protein consumption of normal human individuals is increased from 0.5, to 1.5, to 2.5 gm. of protein per kilo body weight, the specific gravity of the plasma rises and the hematocrit value falls. The analysis of variance demonstrates that the change in protein consumption is a significant but minor factor in d... | 18,904,220 |
Studies in biochemical genetics in Drosophila. | The metabolism of the imaginal discs of wild type, miniature, vestigial, and four-jointed varieties of Drosophila was investigated using the Cartesian diver ultramicrorespirometer. Wild type and vestigial wing disc respiration is inhibited by cyanide and azide and thus is mediated by an iron or copper porphyrin system,... | 18,904,757 |
Studies on the intermediary carbohydrate metabolism of aquatic animals; the distribution of acid-soluble phosphorus and certain enzymes in dolphin tissues. | 1. Liver, kidney, brain, skeletal muscle, and cardiac muscle from one newborn and three adult long-snouted dolphins (Stenella plagiodon) were obtained for enzyme studies. 2. All of the dolphin tissues exhibited cytochrome oxidase, succinic dehydrogenase, and malic dehydrogenase activity. Considerable differences in the... | 18,904,758 |
The reaction between actomyosin and adenosine triphosphate. | 1. A study is made of the effect of adenosine triphosphate (ATP) upon the viscosity of solutions of actomyosin in 0.5 M KCl. 2. The observed effects are discussed in terms of an initial drop of the viscosity (viscosity response) and its subsequent slow reversal (recovery effect). The latter is ascribed to a decrease in... | 18,904,759 |
Effect of enzyme inhibitors and activators on the multiplication of typhus rickettsiae; correlation of effects of PABA and KCN with oxygen consumption in embryonate eggs. | A technique is described for measuring the oxygen uptake of embryonate eggs. Statistical analysis has shown that the method is reliable and accurate. Determinations were made on groups of 15 to 20 eggs, in order to average out individual biological variations. Reduction of the CO(2) tension and relative humidity to app... | 18,908,221 |
The proteins in unheated culture filtrates of human tubercle bacilli; fractionation and determination of physical-chemical properties. | Concentrated culture filtrates of two strains of human tubercle bacilli, a virulent and a slightly virulent one, have been fractionated to give fourteen fractions in each case. Chemical determinations and sedimentation velocity measurements have been carried out on those fractions for which significant results could be... | 18,908,224 |
The proteins in unheated culture filtrates of human tubercle bacilli; determination of serological properties. | 1. Only two serologically different proteins were found in the unheated culture filtrates of both virulent and slightly virulent tubercle bacilli. One of them was the protein which had a sedimentation constant of 3.4 S, and the other was in filtrate fractions with a constant of 2 S. 2. That these proteins were distinct... | 18,908,225 |
Phage formation in Staphylococcus muscae cultures; a factor necessary for phage formation. | 1. A factor necessary for the formation, of Staphylococcus muscae phage was found in acid digests of many highly purified proteins. 2. The factor is released from egg albumen and pepsin by peptic digestion. 3. No amino acids tried could replace the acid digests of proteins as a source of the factor. 4. The factor, when... | 18,920,610 |
Two different proteases from Streptomyces hygroscopicus are involved in transglutaminase activation. | Transglutaminase (TGase), the only commercial enzyme in the food industry capable of introducing covalent bonds to proteins, is secreted as a zymogen (Pro-TGase) in several Streptomyces species. In previous studies, only a metalloprotease has been isolated from Streptomyces mobaraensis as an endogenous TGase-activating... | 18,921,967 |
Alkylresorcinols in wheat varieties in the HEALTHGRAIN Diversity Screen. | The contents of alkylresorcinols (AR) were analyzed in 131 winter wheats, 20 spring wheats, 10 durum wheats, 5 spelt wheats, and 10 early cultivated forms of wheat (5 diploid einkorn and 5 tetraploid emmer), which are part of the HEALTHGRAIN diversity screen. AR were analyzed by gas chromatography (GC), which provides ... | 18,921,971 |
Topological analysis of the reaction of uranium ions (U+, U2+) with N2O in the gas phase. | Density functional theory calculations were performed to study the ability of uranium cations, U(+) and U(2+), to activate the N-N and N-O bonds of N(2)O. A close description of the reaction pathways leading to different reaction products is presented. The obtained results are compared with previous experimental works.... | 18,921,990 |
Relative and absolute stereochemistry of quinadoline B, an inhibitor of lipid droplet synthesis in macrophages. | New fungal metabolites, designated quinadolines A (1) and B (2), were isolated from culture broth of Aspergillus sp. FKI-1746, and their structures were elucidated by NMR spectroscopy. The complete relative and absolute stereochemistry of 2 was determined by X-ray crystallography and amino acid analysis using a chiral ... | 18,922,003 |
The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells. | Genistein, a widely consumed bioflavonoid with chemopreventative properties in adults, and etoposide, a commonly prescribed anticancer drug, are well-characterized topoisomerase II poisons. Although both compounds display similar potencies against human topoisomerase IIalpha and IIbeta in vitro and induce comparable le... | 18,922,022 |
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