title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Probing phenylalanine/adenine pi-stacking interactions in protein complexes with explicitly correlated and CCSD(T) computations. | To examine the effects of pi-stacking interactions between aromatic amino acid side chains and adenine bearing ligands in crystalline protein structures, 26 toluene/(N9-methyl)adenine model configurations have been constructed from protein/ligand crystal structures. Full geometry optimizations with the MP2 method cause... | 18,922,031 |
A concise synthesis of pawhuskin A. | Pawhuskin A is an isoprenylated stilbene that was isolated from Dalea purpurea and reported to have affinity for the opioid receptor in vitro. It has been synthesized through a convergent sequence that joins a prenylated aldehyde with a geranylated phosphonate in a stereoselective Horner-Wadsworth-Emmons condensation t... | 18,922,035 |
Rapid interhemispheric switching during vocal production in a songbird. | To generate complex bilateral motor patterns such as those underlying birdsong, neural activity must be highly coordinated across the two cerebral hemispheres. However, it remains largely elusive how this coordination is achieved given that interhemispheric communication between song-control areas in the avian cerebrum... | 18,922,044 |
Multibend endoscope facilitates endoscopic hemostasis for bleeding gastric ulcer at high lesser curvature. | Bleeding peptic ulcer located high at a lesser curvature is one of the factors that predicted the failure of endoscopic therapy. One of the reasons is the technical difficulty in targeting the bleeding point over a gastric ulcer located high at a lesser curvature. A multibend endoscope was initially developed to facili... | 18,922,060 |
Laparoscopically assisted extrahepatic cyst excision and left hemihepatectomy for a type IV-A choledochal cyst. | Some studies have reported on laparoscopic excision for treating the choledochal cyst, yet there are no reports on laparoscopic surgery for treating type IV-A choledochal cysts that require a liver resection. In this paper, we report on a case of laparoscopic cyst excision combined with left hemihepatectomy and laparos... | 18,922,063 |
Laparoscopic liver resection for cancer. | The field of laparoscopic liver resection surgery has rapidly evolved, with more than 1000 cases now reported. Laparoscopic hepatic resection was initially described for small, peripheral, benign lesions. Experienced teams are now performing laparoscopic anatomic resections for cancer. Operative times improved with exp... | 18,922,123 |
Diurnal temperature range as a novel risk factor for COPD death. | Although the relationship between day-to-day temperature changes and COPD mortality is well established, it is not known whether temperature variation within one day, that is diurnal temperature range (DTR), is a risk factor for acute COPD death, independent of the absolute temperature level. In a time-series study, th... | 18,922,144 |
Physical and in silico approaches identify DNA-PK in a Tax DNA-damage response interactome. | We have initiated an effort to exhaustively map interactions between HTLV-1 Tax and host cellular proteins. The resulting Tax interactome will have significant utility toward defining new and understanding known activities of this important viral protein. In addition, the completion of a full Tax interactome will also ... | 18,922,151 |
Rapid and reliable diagnosis of murine myeloid leukemia (ML) by FISH of peripheral blood smear using probe of PU. 1, a candidate ML tumor suppressor. | Murine myeloid leukemia (ML) provides a good animal model to study the mechanisms of radiation-induced leukemia in humans. This disease has been cytogenetically characterized by a partial deletion of chromosome 2 with G-banding. For the rapid diagnosis of ML, this study reports a FISH method using spleen cells and peri... | 18,922,187 |
Outbreak of subclinical mastitis in a flock of dairy goats associated with atypical Staphylococcus haemolyticus. | Staphylococcus haemolyticus is a pathogen frequently isolated from dairy cows and small ruminants. However, it always appears in only a few animals and not as a major pathogen. Recently, in a dairy goat herd of approximately 250 milking animals, 25.6% (46/180 goats) had milk cultures with atypical highly mucoid colonie... | 18,922,198 |
The antidepressant venlafaxine ameliorates murine experimental autoimmune encephalomyelitis by suppression of pro-inflammatory cytokines. | Antidepressants are known to impact on the immune system. In this study, we examined the immunomodulatory properties of venlafaxine, a selective serotonin/norepinephrine reuptake inhibitor (SNRI), in murine experimental autoimmune encephalomyelitis (EAE), a T-cell-mediated CNS demyelinating disease model of multiple sc... | 18,922,202 |
Is there utility in the transtheoretical model? | The transtheoretical model is arguably the dominant model of health behaviour change, having received unprecedented research attention, yet it has simultaneously attracted exceptional criticism. However, the criticisms have been directed almost exclusively at the stages of change, just one of fourteen components of the... | 18,922,209 |
[The relationship between physical activity and plasma homocysteine level in young men]. | There is a wealth of studies indicating that elevated concentration of plasma homocysteine (hyperhomocystemia) is one of the risk factors for cardiovascular disease. Additionally, it is documented that plasma homocysteine levels are affected by gender, fat free mass, dietary habits and physical activity. However, data ... | 18,922,224 |
[Clinical particularism of bipolar disorder: unipolar mania. About a patient's study in Tunesia]. | Although present classifications (CIM, DSM) have not included the notion of a unipolar disorder to characterise the recurrence of the same type of episode, this concept conserves its pertinence for many people. Unipolar mania, in particular, is a clinical reality in our daily practice, and a predominant form of bipolar... | 18,922,234 |
Effect of phosphate group addition on the properties of denture base resins. | Acrylic resins are prone to microbial adherence, especially by Candida albicans. Surface-charged resins alter the ionic interaction between the denture resin and Candida hyphae, and these resins are being developed as a means to reduce microbial colonization on the denture surface. The purpose of this study was to inve... | 18,922,259 |
Adhesion of Streptococcus mutans NCTC 10449 to artificial teeth: an in vitro study. | Plaque on dentures may foster the occurrence of denture stomatitis and periodontal diseases in gingival tissues adjacent to partial dentures. Thus, it is beneficial for dental materials to have a low susceptibility to plaque adhesion. The purpose of this study was to evaluate the susceptibility of commonly used artific... | 18,922,260 |
Neurovascular emergencies in the elderly. | Neurovascular diseases are major causes of disability and death in the elderly; many present as medical emergencies. With the continuing growth of the geriatric population, there has been increasing interest in the impact of aging on the cerebrovascular system. Recent advances in the clinical neurosciences have demonst... | 18,922,295 |
Safely navigating around the facial nerve in three dimensions. | Although much literature discusses the anatomy and injury of the facial nerve branches, the fascial plane of the nerves, particularly where they transition from one plane to another, is rarely emphasized and information is often contradictory. This article describes in three-dimensional, accurate surgical terms where t... | 18,922,299 |
Surgical results of the intraoral removal of the submandibular gland. | Most patients with benign submandibular disorders have been treated surgically without difficulty via the transcervical approach. An alternative to the standard transcervical approach has been reported such as an intraoral approach. Retrospective chart review of the 77 patients with benign submandibular disorders. All ... | 18,922,339 |
Paranasal sinus mucoceles with skull-base and/or orbital erosion: is the endoscopic approach sufficient? | The objective of this study was to review the management of paranasal sinus mucoceles with skull-base and/or orbital erosion in the endoscopic era. A retrospective data analysis. A chart review was performed on 57 patients treated from January 2001 to March 2007. The average age at the time of presentation was 50.6 yea... | 18,922,346 |
Cross-linked polyethylene in total knee arthroplasty: in opposition. | Highly cross-linked polyethylene has been used with success in total hip arthroplasty. The reduction of femoral head penetration has been a uniform finding among researchers at 5 to 7 years of follow-up. However, there have also been newly highlighted modes of failure, as increased brittleness of the material can adver... | 18,922,371 |
Association of cytochrome P450 1B1 gene expression in peripheral leukocytes with blood lipid levels in waste incinerator workers. | This study investigated whether CYP1B1 gene expression was associated with blood lipids levels. Workers from a municipal waste incineration plant in Taiwan participated in a questionnaire survey and physical examination and provided fasting blood samples for blood lipid analysis. CYP1B1 gene expression in workers' leuk... | 18,922,394 |
Patient monitoring during gastrointestinal endoscopy: why, when, and how? | Patient monitoring is intended to reduce the risk of sedation-related cardiopulmonary complications. Physiological monitoring and visual assessment by a qualified individual should be routine during endoscopic procedures. Additionally, ventilatory monitoring should be considered for high-risk patients and those receivi... | 18,922,405 |
A performance improvement program for community-based gastroenterology. | A robust performance improvement program based in a community gastrointestinal (GI) practice is described. The need for continual improvement and attention to both quality and the bottom line is now essential for independent GI practices. This article provides both a roadmap for developing a program and benchmarks deri... | 18,922,413 |
The effects of vasodilation on cardiac output measured by PiCCO. | The purpose of this study was to investigate the effects of vasodilation on cardiac output (CO) measured by pulse contour method using PiCCO (Pulsion Medical Systems AG, Munich, Germany) in comparison with CO by the thermodilution method. A prospective observational study. An operating room in a university hospital. Tw... | 18,922,424 |
Levosimendan in aortic valve surgery: cardiac performance and recovery. | The aim of the present study was to test the hypothesis that levosimendan has beneficial effects on cardiac performance and that the need for other vasoactive medications during and after cardiac surgery would be reduced by levosimendan in patients with severe aortic stenosis (AS) and left ventricular (LV) hypertrophy.... | 18,922,425 |
Acute Physiology and Chronic Health Evaluation (APACHE) III outcome prediction after major vascular surgery. | To investigate the performance of the Acute Physiology and Chronic Health Evaluation (APACHE) III scoring system in patients admitted to the intensive care unit (ICU) after major vascular surgery. Retrospective cohort study. A tertiary referral center. Three thousand one hundred forty-eight patients who underwent major... | 18,922,428 |
Computed tomography and magnetic resonance cholangiography. | In patients with biliary obstruction, determining the level and the cause of the obstruction is essential because it can be a key factor for the next step in diagnostic or therapeutic intervention. Noninvasive cholangiography, such as computed tomography (CT) cholangiography or magnetic resonance (MR) cholangiography, ... | 18,922,453 |
Cholangioscopy. | Direct visualization of the bile ducts and gall bladder via cholangioscopy is very useful both in treatment of complex stone cases and the assessment of indeterminate strictures or masses. It allows use of instruments that cannot be used safely with fluoroscopic guidance alone. It also increases procedural efficiency a... | 18,922,458 |
Percutaneous management of postoperative anastomotic biliary strictures. | Postoperative anastomotic biliary strictures can occur after surgery in bile ducts belonging to transplanted or native (nontransplanted) livers. The majority of postoperative anastomotic strictures encountered by interventional radiologists are most likely in liver transplant recipients due to the large and growing liv... | 18,922,459 |
History of community health center affiliations with The New England College of Optometry. | Since the 1970s, The New England College of Optometry (NECO) has been a leader in community-based educational programming. This was accomplished through the development of affiliation agreements with health care facilities that care for the underserved, notably community health centers (CHCs). The college's clinical sy... | 18,922,496 |
Risk factors for repeat adverse asthma events in children after visiting an emergency department. | The aim of this study was to identify risk factors for long-term adverse outcomes in children with asthma after visiting the emergency department (ED). A prospective observational study was conducted at the ED of a pediatric tertiary hospital in Ontario, Canada. Patient outcomes (ie, acute asthma episodes and ED visits... | 18,922,500 |
Effect of WHO newborn care training on neonatal mortality by education. | Ninety-nine percent of the 4 million neonatal deaths per year occur in developing countries. The World Health Organization (WHO) Essential Newborn Care (ENC) course sets the minimum accepted standard for training midwives on aspects of infant care (neonatal resuscitation, breastfeeding, kangaroo care, small baby care, ... | 18,922,503 |
Impact of a patient-centered technology on medication errors during pediatric emergency care. | The aim of this study was to determine the impact of a patient-centered health information technology (HIT) on the error rate for ordering and prescribing of medications during emergency pediatric care. We conducted a quasi-experimental intervention study by using control and intervention periods to evaluate the effect... | 18,922,507 |
Atherosclerosis progression affects the relationship between endothelial function and aortic stiffness. | Aortic stiffening is the most important determinant of elevated systolic blood pressure which in turn is the main contributor to the burden of disease attributable to hypertension. Endothelial function may affect arterial stiffening as has been shown for carotid-aorto-femoral segments in healthy humans or subjects with... | 18,922,528 |
Maedi-visna: the meningoencephalitis in naturally occurring cases. | Lesions were examined at different levels of the central nervous system (CNS) in 64 sheep with natural maedi-visna (MV) meningoencephalitis. All animals showed lesions in more than one of the CNS locations examined; the lesions in the cranial regions were periventricular, while those in the spinal cord affected the whi... | 18,922,546 |
Energy intake affects the biotransformation rate, scope for induction, and metabolite profile of benzo[a]pyrene in rainbow trout. | The metabolic conversion of benzo[a]pyrene (B[a]P) by rainbow trout (Oncorhynchus mykiss) hepatocytes was not significantly different between any group of fed fish (fed one of three isoenergetic diets that varied in protein and lipid content at full satiation levels or half rations), however at 12 weeks, fasted fish ex... | 18,922,589 |
Effects of low intensity exercise therapy on early phase insulin secretion in overweight subjects with impaired glucose tolerance and type 2 diabetes mellitus. | This study was designed to evaluate effects of exercise therapy on early phase insulin secretion in overweight subjects with impaired glucose tolerance (IGT) and type 2 diabetes mellitus (DM). The subjects consisted of overweight subjects with normal glucose tolerance (NGT, n=10), IGT (n=10) and DM (n=10) (age: 51.1+/-... | 18,922,594 |
The association of plasma fibrinogen concentration with diabetic microvascular complications in young adults with early-onset of type 2 diabetes. | Diabetic nephropathy is an important risk factor for cardiovascular diseases (CVD). The underlying etiology is not fully understood but may be related to changes in inflammatory and hemostatic markers with kidney disease. We investigated the associations of the markers with microvascular complications in Pima Indians (... | 18,922,595 |
Sirt1 increases skeletal muscle precursor cell proliferation. | It is important to understand the mechanisms that control muscle precursor cell (MPC) proliferation for the development of countermeasures to offset the deleterious effects of the aging-related loss of skeletal muscle mass (and myonuclei) and the impaired ability of old muscle to regrow and regenerate. Over-expression ... | 18,922,599 |
Expanding the scope of practice for enrolled nurses working in an Australian rural health service - implications for job satisfaction. | Career opportunities have been limited for enrolled nurses (ENs) working in small, rural health services. Medication endorsement offers ENs expanded scope of practice which may lead to improved job satisfaction. This small study compared job satisfaction between a group of ENs with recent medication endorsement and a g... | 18,922,605 |
Dentine bonding after CPP-ACP paste treatment with and without conditioning. | To evaluate microshear bond strength (MSBS) to dentine following application of a casein phosphopeptide amorphous calcium phosphate paste (Tooth Mousse (TM)), and the effect of smear layer removal before paste application and preconditioning. Specimens of polished human dentine were divided into two groups: 1, smear la... | 18,922,613 |
Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma. | Multiple myeloma (MM) is presently an incurable malignant plasma cell tumor. The objective of this study was to investigate expression of the interferon regulatory factor family (IRF1-9) and the potential role of DNA methylation in silencing IRF genes in MM cell lines and purified MM cells from patients. Using a panel ... | 18,922,617 |
Magnetic resonance imaging of melanoma metastases in a clinical relevant human melanoma xenograft scid mouse model. | This study aimed to analyse (i) the metastatic behaviour of human melanoma FEMX-1 cells in scid mice after surgical excision of the PT and (ii) to evaluate the feasibility of magnetic resonance imaging (MRI) for the detection of melanoma metastases. Histology proved both high specificity (95%), and high sensitivity of ... | 18,922,631 |
Acute death in heartworm-infected cats: unraveling the puzzle. | Although the acute death syndrome in feline heartworm disease is widely recognized, its pathogenesis remains a mystery. The most widely held hypothesis is that an acute anaphylactic reaction, perhaps precipitated by the death of the parasite, is the underlying cause. This study investigated the role of the physical for... | 18,922,636 |
Aichi cancer center initial experience of intensity modulated radiation therapy for nasopharyngeal cancer using helical tomotherapy. | To assess the feasibility of helical tomotherapy (HT) for patients with nasopharyngeal carcinoma. From June 2006 to June 2007, 20 patients with nasopharyngeal carcinoma were treated with HT with (n = 18) or without (n = 2) systemic chemotherapy. The primary tumor and involved lymph node (PTV1) were prescribed 70 Gy and... | 18,922,651 |
There is no correlation between erectile dysfunction and dose to penile bulb and neurovascular bundles following real-time low-dose-rate prostate brachytherapy. | We evaluated the relationship between the onset of erectile dysfunction and dose to the penile bulb and neurovascular bundles (NVBs) after real-time ultrasound-guided prostate brachytherapy. One hundred forty-seven patients who underwent prostate brachytherapy met the following eligibility criteria: (1) treatment with ... | 18,922,652 |
Effects of a short-term exposure to alcohol in rats on FAAH enzyme and CB1 receptor in different brain areas. | Acute alcohol exposure in rats (8% ethanol in the liquid diet for a period of 24 h) is associated with a decrease in the levels of endocannabinoids (anandamide and 2-arachidonoyl-glycerol) as well as in various N-acylethanolamines, in different brain regions. In the present study, we wanted to further explore: (i) whet... | 18,922,654 |
Quantitative analysis of nerve growth factor (NGF) in the atopic dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic dermatitis. | The expression of nerve growth factor (NGF) is known to increase in the skin of patients with atopic dermatitis (AD) and is related to disease aggravation. In the present study, we measured skin NGF levels in AD patients and determined whether they correlate to AD severity as well as treatment effects. NGF in the horny... | 18,922,683 |
Biomolecular solid state NMR with magic-angle spinning at 25K. | A magic-angle spinning (MAS) probe has been constructed which allows the sample to be cooled with helium, while the MAS bearing and drive gases are nitrogen. The sample can be cooled to 25K using roughly 3 L/h of liquid helium, while the 4-mm diameter rotor spins at 6.7 kHz with good stability (+/-5 Hz) for many hours.... | 18,922,715 |
No relationship between mean plasma glucose and glycated haemoglobin in patients with cystic fibrosis-related diabetes. | Cystic fibrosis-related diabetes (CFRD) prevalence has increased dramatically with the improved life expectancy of patients with cystic fibrosis (CF). Glycated haemoglobin (HbA(1c)) is an important tool for monitoring blood glucose control but, unlike in type 1 and type 2 diabetes, a correlation between HbA(1c), fructo... | 18,922,724 |
Intrasyrinx hemorrhage associated with hemangioblastoma in epiconus. | Hemangioblastomas in the central nervous system are highly vascular lesions, but have low risk of hemorrhage. In spinal lesions, there are a few rare cases of intramedullary hemorrhages associated with hemangioblastoma, and their prognoses were very severe. This is the first case of an intrasyrinx hemorrhage associated... | 18,922,743 |
Simultaneous analysis of THC and its metabolites in blood using liquid chromatography-tandem mass spectrometry. | Cannabis is considered to be the most widely abused illicit drug in Europe. Consequently, sensitive and specific analytical methods are needed for forensic purposes and for cannabinoid pharmacokinetic and pharmacodynamic studies. A simple, rapid and highly sensitive and specific method for the extraction and quantifica... | 18,922,747 |
Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits. | White-matter damage is a leading cause of neurological handicap. Although hypoxia-ischemia and excitotoxicity are major pathogenic factors, a role for genetic influences was suggested recently. Thus, protracted gestational hypoxia was associated with white-matter damage (WMD) in rat pups but not in mouse pups. Indeed, ... | 18,922,769 |
A host dicer is required for defective viral RNA production and recombinant virus vector RNA instability for a positive sense RNA virus. | Defective interfering (DI) RNAs, helper virus-dependent deletion mutant RNAs derived from the parental viral genomic RNA during replication, have been described for most RNA virus taxonomic groups. We now report that DI RNA production in the chestnut blight fungus, Cryphonectria parasitica, persistently infected by vir... | 18,922,782 |
Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation. | The balance between differentiation signals and signals maintaining the undifferentiated state of embryonic cells ensures proper formation of germ layers. The nodal/activin pathway represents one of the major signaling chains responsible for the differentiation of embryonic cells into mesodermal and endodermal germ lay... | 18,922,797 |
Reconstructing tumor-wise protein expression in tissue microarray studies using a Bayesian cell mixture model. | Tissue microarrays (TMAs) quantify tissue-specific protein expression of cancer biomarkers via high-density immuno-histochemical staining assays. Standard analysis approach estimates a sample mean expression in the tumor, ignoring the complex tissue-specific staining patterns observed on tissue arrays. In this article,... | 18,922,808 |
Childhood leukaemia following medical diagnostic exposure to ionizing radiation in utero or after birth. | A statistical association between childhood leukaemia and an abdominal X-ray examination of the pregnant mother was first reported in 1956 from a case-control study of childhood cancer mortality conducted in Great Britain. This study, later called the Oxford Survey of Childhood Cancers (OSCC), was continued and eventua... | 18,922,822 |
Current and emerging strategies for the management of acute myeloid leukemia in the elderly. | Acute myeloid leukemia (AML) accounts for approximately 80% of acute leukemias diagnosed in adults. The elderly are disproportionately affected by AML, as 35% of newly diagnosed patients are aged >or=75 and the median age at diagnosis is 67. Elderly individuals also respond less well to standard chemotherapy than do... | 18,922,830 |
Switching first-line disease-modifying therapy after failure: impact on the course of relapsing-remitting multiple sclerosis. | Options for non-responders to relapsing-remitting multiple sclerosis (RRMS) first-line disease-modifying therapies (DMT) are limited. We explored whether switching first-line DMT is effective. Patients with RRMS who first received interferon-beta (IFNB) or glatiramer acetate (GA) were classified in three categories: DM... | 18,922,831 |
Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA). | We examined copy number changes in the genomes of B cells from 58 patients with chronic lymphocytic leukemia (CLL) by using representational oligonucleotide microarray analysis (ROMA), a form of comparative genomic hybridization (CGH), at a resolution exceeding previously published studies. We observed at least 1 genom... | 18,922,857 |
Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. | Inactivation of the transforming growth factor beta (TGFbeta) tumor suppressor pathway is a main step in the development of a variety of human tumors. The miR-106b-25 and miR-17-92 clusters are emerging as key modulators of TGFbeta signaling in gastrointestinal and other tumors, interfering with cell cycle arrest and a... | 18,922,889 |
Utilization of pathway signatures to reveal distinct types of B lymphoma in the Emicro-myc model and human diffuse large B-cell lymphoma. | The Emu-myc transgenic mouse has provided a valuable model for the study of B-cell lymphoma. Making use of gene expression analysis and, in particular, expression signatures of cell signaling pathway activation, we now show that several forms of B lymphoma can be identified in the Emu-myc mice associated with time of t... | 18,922,927 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. | An extraordinary new technique using hyperpolarized (13)C-labeled pyruvate and taking advantage of increased glycolysis in cancer has the potential to improve the way magnetic resonance imaging is used for detection and characterization of prostate cancer. The aim of this study was to quantify, for the first time, diff... | 18,922,937 |
NADPH oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension. | The goal of this study was to test the hypothesis that NADPH oxidase contributes importantly to renal cortical oxidative stress and inflammation, as well as renal damage and dysfunction, and increases in arterial pressure. Fifty-four 7- to 8-wk-old Dahl salt-sensitive (S) or R/Rapp strain rats were maintained for 5 wk ... | 18,922,960 |
Validation, performance under field conditions, and cost-effectiveness of Capillus HIV-1/HIV-2 and determine HIV-1/2 rapid human immunodeficiency virus antibody assays using sequential and parallel testing algorithms in Tanzania. | Rapid human immunodeficiency virus (HIV) antibody tests support the effort to expand access to HIV testing and counseling services in remote, rural, and poor parts of the world. We validated the Capillus HIV-1/HIV-2 (Trinity Biotech PLC, Bray, County Wicklow, Ireland) and Determine HIV-1/2 (Abbott Laboratories, Abbott ... | 18,923,015 |
Loss of inhibitory neuron AMPA receptors contributes to ataxia and epilepsy in stargazer mice. | Stargazer mice are characterized by ataxia and seizures, which resemble the human disorder absence epilepsy. Stargazin, the protein mutated in stargazer mice, promotes the expression and function of neuronal AMPA receptors (AMPARs). However, it is unclear how decreased expression of excitatory AMPARs generates stargaze... | 18,923,036 |
Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes. | p21-Activated kinase-1 (Pak1) is a serine-threonine kinase that associates with and activates protein phosphatase 2A in adult ventricular myocytes and, thereby, induces increased Ca2+ sensitivity of skinned-fiber tension development mediated by dephosphorylation of myofilament proteins (Ke Y, Wang L, Pyle WG, de Tombe ... | 18,923,061 |
DNA helicases Sgs1 and BLM promote DNA double-strand break resection. | A key cellular response to DNA double-strand breaks (DSBs) is 5'-to-3' DSB resection by nucleases to generate regions of ssDNA that then trigger cell cycle checkpoint signaling and DSB repair by homologous recombination (HR). Here, we reveal that in the absence of exonuclease Exo1 activity, deletion or mutation of the ... | 18,923,075 |
Economic outcomes of a dental electronic patient record. | The implementation of an electronic patient record (EPR) in many sectors of health care has been suggested to have positive relationships with both quality of care and improved pedagogy, although evaluation of actual results has been somewhat disillusioning. Evidence-based dentistry clearly suggests the need for tools ... | 18,923,100 |
The IKK-neutralizing compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent activation-induced cell death. | Antigen with dual costimulation through CD137 and CD134 induces powerful CD8 T cell responses. These effector T cells are endowed with an intrinsic survival program resulting in their accumulation in vivo, but the signaling components required for survival are unknown. We tested a cadre of pathway inhibitors and found ... | 18,923,104 |
The association between perceived discrimination and obesity in a population-based multiracial and multiethnic adult sample. | We examined whether perceived chronic discrimination was related to excess body fat accumulation in a random, multiethnic, population-based sample of US adults. We used multivariate multinomial logistic regression and logistic regression analyses to examine the relationship between interpersonal experiences of perceive... | 18,923,119 |
Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. | Mps1 is a protein kinase that plays essential roles in spindle checkpoint signaling. Unattached kinetochores or lack of tension triggers recruitment of several key spindle checkpoint proteins to the kinetochore, which delays anaphase onset until proper attachment or tension is reestablished. Mps1 acts upstream in the s... | 18,923,149 |
Long-term effects of delayed fatherhood in mice on postnatal development and behavioral traits of offspring. | This study aims to analyze, in mice, the long-term effects of delayed fatherhood on postnatal development, spontaneous motor activity, and learning capacity of offspring. Hybrid parental-generation (F(0)) males, at the age of 12, 70, 100, and 120 wk, were individually housed with a randomly selected 12-wk-old hybrid fe... | 18,923,158 |
Chronic-intermittent cold stress in rats induces selective ovarian insulin resistance. | In rat ovary chronic cold stress increases sympathetic nerve activity, modifies follicular development, and initiates a polycystic condition. To see whether there is a relationship between the previously described changes in follicular development and metabolic changes similar to those in women with polycystic ovary, w... | 18,923,160 |
Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? | Except in rare cases, the stomach can withstand exposure to highly concentrated hydrochloric acid, refluxed bile salts, alcohol, and foodstuffs with a wide range of temperatures and osmolarity. This is attributed to a number of physiological responses by the mucosal lining to potentially harmful luminal agents, and to ... | 18,923,189 |
Combining results from lectin affinity chromatography and glycocapture approaches substantially improves the coverage of the glycoproteome. | Identification of glycosylated proteins, especially those in the plasma membrane, has the potential of defining diagnostic biomarkers and therapeutic targets as well as increasing our understanding of changes occurring in the glycoproteome during normal differentiation and disease processes. Although many cellular prot... | 18,923,192 |
An integral conservative gridding--algorithm using Hermitian curve interpolation. | The problem of re-sampling spatially distributed data organized into regular or irregular grids to finer or coarser resolution is a common task in data processing. This procedure is known as 'gridding' or 're-binning'. Depending on the quantity the data represents, the gridding-algorithm has to meet different requireme... | 18,923,199 |
Treatment seeking behavior for urinary incontinence among north Indian women. | Urinary incontinence is a common but neglected problem of women. To ascertain the treatment seeking behavior of north Indian women having urinary incontinence (UI). Two residential colonies of Chandigarh. Cross-sectional face-to-face interview based study. This study was conducted by a trained nurse during April 2005-J... | 18,923,213 |
Comparison of oral ketamine and oral midazolam as sedative agents in pediatric dentistry. | The safe and effective treatment of uncooperative or combative preschool children with extensive dental needs is one of pediatric dentist's ongoing challenges. The traditional methods of behavior management are no longer acceptable to parents as they are not ready to spare more time for dental treatment of their childr... | 18,923,220 |
Cemento-ossifying fibroma--a rare case. | The concept of 'fibro-osseous lesions' of bone has evolved over the last several decades and now includes two major entities: fibrous dysplasia and ossifying fibroma, as well as the other less common lesions such as florid osseous dysplasia, periapical dysplasia, focal sclerosing osteomyelitis, proliferative periostiti... | 18,923,226 |
Device-based nonspecific immunomodulation therapy (Celacade), and its potential role in the treatment of chronic heart failure. | Chronic heart failure (CHF) remains a leading cause of mortality and morbidity, despite the use of optimal standard-of-care medical therapies. Although the role of the immune system in the pathogenesis and progression of CHF has been well-appreciated, attempts to modify specific systemic immune mediators have been unsu... | 18,923,231 |
Prasugrel: a new antiplatelet drug for the prevention and treatment of cardiovascular disease. | Prasugrel, trade name Effient, is an investigational new antiplatelet drug currently under review for clinical use by the Food and Drug Administration. It is a thienopyridine analog with a structure similar to that of clopidogrel and ticlopidine. Thienopyridine derivatives inhibit platelet aggregation induced by adenos... | 18,923,235 |
Effects of facetectomy and crosslink augmentation on motion segment flexibility in posterior lumbar interbody fusion. | Biomechanical assessment using calf lumbar motion segments. To determine whether facetectomy affects the primary stability of posterior lumbar interbody fusion. To improve visualization and access to the disc space, the facet joints frequently are removed. Previous biomechanical studies have indicated a fundamental rol... | 18,923,306 |
Innovative management of anal fistula by the use of the anal fistula plug: hype or help? | Impressed by the initial success rates of 80% of the anal fistula plug for the closure of cryptoglandular and Crohn's associated anorectal fistulas, preliminary results from centers world-wide showed a healing rates between 24% and 88%. When compared to traditional flap repair for closing high anorectal fistulas, impai... | 18,923,352 |
Delayed presentation of diaphragmatic rupture as intra-thoracic gastric volvulus. | Diaphragmatic injuries are quite rare and result from either blunt or penetrating trauma. They are not always recognized at the time of injury and there is often a delay between the trauma and the diagnosis The diagnosis is confirmed by chest X-ray, USG, CT Scan and barium studies This case report discusses the delayed... | 18,923,354 |
Focus on urinary bladder cancer markers: a review. | Finding and development of new bladder cancer markers is still a very dynamic field. Because of the mass of all these markers it is impossible to report all of them. This paper reviews the role of bladder cancer markers in diagnosis and highlights the most important biomarkers studied and reported recently. A medline b... | 18,923,360 |
Management of early-invasive high-grade transitional cell carcinoma of the bladder. | The decision in favor or against an early cystectomy in patients with initial pT1G3 urothelial carcinoma of the bladder (UCBC) is challenging. In the present review the authors dwell on the key issues in the controversial discussion about optimal management of so called ''early invasive'' UCBC. The quality of transuret... | 18,923,363 |
High prevalence of neuropathy in patients with impaired 60-minute oral glucose tolerance test but normal fasting and 120-minute glucose levels. | The aim of this study was to define the prevalence of neuropathy in patients with impaired 60-min oral glucose tolerance test (OGTT) but normal fasting and 120-min glucose levels and to evaluate risk factors for polyneuropathy and glucose intolerance. The hospital files of 320 patients (56.5+/-11.9 years, 73.1% female)... | 18,923,366 |
Bending properties of nickel-titanium instruments: a comparative study. | The aim of the present study was to evaluate the bending properties of twisted file instruments, and compare them with other commercially available nickel-titanium (NiTi) instruments (Mtwo and Hero) manufactured with traditional methods. Despite NiTi superelastic properties, flexibility of NiTi instruments is limited b... | 18,923,374 |
Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension. | Angiotensin II stimulates the formation of reactive oxygen species by increased NADPH oxidase activity, which contributes to proapoptotic and profibrotic mechanisms critical in renal injury. Here we determine if apocynin, an inhibitor of NADPH oxidase, interferes with the action of the intrarenal renin-angiotensin syst... | 18,923,387 |
Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose. | Acetaminophen protein adducts (APAP adducts) were quantified in 157 adolescents and children presenting at eight pediatric hospitals with the chief complaint of APAP overdose. Two of the patients required liver transplantation, whereas all the others recovered spontaneously. Peak APAP adducts correlated with peak hepat... | 18,923,390 |
The Phaeodactylum genome reveals the evolutionary history of diatom genomes. | Diatoms are photosynthetic secondary endosymbionts found throughout marine and freshwater environments, and are believed to be responsible for around one-fifth of the primary productivity on Earth. The genome sequence of the marine centric diatom Thalassiosira pseudonana was recently reported, revealing a wealth of inf... | 18,923,393 |
EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane curvature-dependent actin polymerization. | Extended Fer-CIP4 homology (EFC)/FCH-BAR (F-BAR) domains generate and bind to tubular membrane structures of defined diameters that are involved in the formation and fission of endocytotic vesicles. Formin-binding protein 17 (FBP17) and Toca-1 contain EFC/F-BAR domains and bind to neural Wiskott-Aldrich syndrome protei... | 18,923,421 |
Correction of dystrophia myotonica type 1 pre-mRNA transcripts by artificial trans-splicing. | Dystrophia myotonica type 1 (DM1), the most common muscular dystrophy in adults, results from expansion of a CTG repeat in the 3'-untranslated region of the dystrophia myotonica protein kinase gene (DMPK). Correction of the mutant DMPK transcript is a potential therapeutic strategy in DM1. We investigated the efficacy ... | 18,923,454 |
Failure of neuronal homeostasis results in common neuropsychiatric phenotypes. | Failure of normal brain development leads to mental retardation or autism in about 3% of children. Many genes integral to pathways by which synaptic modification and the remodelling of neuronal networks mediate cognitive and social development have been identified, usually through loss of function. Evidence is accumula... | 18,923,513 |
Pairs of cooperating cleaner fish provide better service quality than singletons. | Service providers may vary service quality depending on whether they work alone or provide the service simultaneously with a partner. The latter case resembles a prisoner's dilemma, in which one provider may try to reap the benefits of the interaction without providing the service. Here we present a game-theory model b... | 18,923,522 |
Activating mutations in ALK provide a therapeutic target in neuroblastoma. | Neuroblastoma, an embryonal tumour of the peripheral sympathetic nervous system, accounts for approximately 15% of all deaths due to childhood cancer. High-risk neuroblastomas are rapidly progressive; even with intensive myeloablative chemotherapy, relapse is common and almost uniformly fatal. Here we report the detect... | 18,923,525 |
Development and annotation of perennial Triticeae ESTs and SSR markers. | Triticeae contains hundreds of species of both annual and perennial types. Although substantial genomic tools are available for annual Triticeae cereals such as wheat and barley, the perennial Triticeae lack sufficient genomic resources for genetic mapping or diversity research. To increase the amount of sequence infor... | 18,923,529 |
New resources for studying the rose flowering process. | Knowledge of the flowering process - an important trait in ornamental plants such as roses - is necessary for efficient control of flowering. This study was carried out to develop and characterize new resources to gain further insight into floral control in rose. We studied floral initiation in a nonrecurrent blooming ... | 18,923,534 |
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