title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Dual-source CT coronary angiography in patients with atrial fibrillation: comparison with single-source CT. | To evaluate the performance of dual-source computed tomography (DSCT) for the visualization of the coronary arteries in a population with atrial fibrillation (AF) compared to single-source CT (SSCT) and to explore the impact of patients' heart rate (HR) on image quality (IQ) and reconstruction timing. Thirty consecutiv... | 18,993,003 |
[A case of acquired encephalopathy in a child. A cause that we thought had disappeared]. | Subacute central nervous system infection must be considered in any infant presenting with progressive encephalopathy. We present the case of an 18-month-old child with normal neuromotor development until the age of 14 months admitted for spastic hypertonia of the legs and arms associated with axial hypotonia. The moth... | 18,993,038 |
Maternal dexamethasone and GLP-2 have early effects on intestinal sugar transport in their suckling rat offspring. | Both glucagon-like peptide 2 (GLP-2) and glucocorticosteroids enhance intestinal uptake in mature animals. Maternal stimuli may cause intestinal adaptation in the offspring. We hypothesized that administering GLP-2, dexamethasone (DEX) or a combination of GLP-2+DEX to rat dams during pregnancy and lactation would enhan... | 18,993,047 |
A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects. | Nonsteroidal anti-inflammatory drugs such as aspirin are used for pain relief and chemoprevention against cancer, but frequently cause gastric mucosal injury. We examined whether combinations of aspirin and alpha-tocopherol (alphaT) or aspirin and gamma-tocopherol (gammaT), with alphaT and gammaT being the two major fo... | 18,993,050 |
Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7. | Conjugated linoleic acid (CLA) is a mixture of dietary fatty acids that has various beneficial effects including decreasing cancer, atherosclerosis, diabetes and inflammation in animal models. Some controversy exists on the specific isomers of CLA that are responsible for the benefits observed. This study was conducted... | 18,993,052 |
Mitochondrial and sarcoplasmic protein changes in hearts from copper-deficient rats: up-regulation of PGC-1alpha transcript and protein as a cause for mitochondrial biogenesis in copper deficiency. | Changes in mitochondrial and sarcoplasmic proteins using proteinomics and Western blotting in hearts from copper-deficient rats were explored in this study. Also, key enzymes that are involved in cardiac energy metabolism via glycolysis and fatty acid oxidation and related transcription factors were determined. Rats we... | 18,993,053 |
Topoisomerase II alpha as a marker predicting anthracyclines' activity in early breast cancer patients: ready for the primetime? | This manuscript reviews and discusses results from randomised clinical studies evaluating topoisomerase II alpha (topo II) as a marker predicting anthracyclines' activity in early breast cancer patients. A Medline search has led to the identification of six phase III clinical trials, in which topo II has been retrospec... | 18,993,056 |
Cadmium tolerance and adsorption by the marine brown alga Fucus vesiculosus from the Irish Sea and the Bothnian Sea. | Cadmium (Cd) uptake capacities and Cd tolerance of the marine alga Fucus vesiculosus from the Irish Sea (salinity 35 psu) and from the Bothnian Sea (northern Baltic, 5 psu) were quantified. These data were complemented by measurements of changes in maximal photosynthetic rate (P(max)), dark respiration rate and variabl... | 18,993,059 |
Attention-dependent representation of a size illusion in human V1. | One of the most fundamental properties of human primary visual cortex (V1) is its retinotopic organization, which makes it an ideal candidate for encoding spatial properties, such as size, of objects. However, three-dimensional (3D) contextual information can lead to size illusions that are reflected in the spatial pat... | 18,993,076 |
Strategies for generating less toxic P-selectin inhibitors: pharmacophore modeling, virtual screening and counter pharmacophore screening to remove toxic hits. | This paper describes the generation of ligand-based as well as structure-based models and virtual screening of less toxic P-selectin receptor inhibitors. Ligand-based model, 3D-pharmacophore was generated using 27 quinoline salicylic acid compounds and is used to retrieve the actives of P-selectin. This model contains ... | 18,993,099 |
Nodular fasciitis with cortical involvement. | We report on the clinical and imaging features--including CT and MRI--of nodular fasciitis with cortical involvement in the shoulder. Nodular fasciitis is a commonly encountered benign soft-tissue fibrous tumor that typically involves the upper extremity and may be mistaken for a sarcomatous lesion because of its rapid... | 18,993,101 |
Application of portable Raman instruments for fast and non-destructive detection of minerals on outcrops. | Raman spectral signatures have been obtained in situ for a series of minerals using portable Raman instruments. Cerussite, anglesite, wulfenite, titanite, calcite, tremolite, andradite and quartz were detected using portable Raman spectrometer First Defender XL (Ahura). Baryte, almandine and realgar Raman spectra obtai... | 18,993,111 |
Seasonal pattern of incidence and case fatality of acute myocardial infarction in a Japanese population (from the Takashima AMI Registry, 1988 to 2003). | We examined the seasonal variations in the incidence and case fatality of acute myocardial infarction (AMI) in a geographically defined population using 16-year AMI registration data. It remains unclear whether the incident events of AMI display any seasonal variation. Documentation of such a pattern may foster investi... | 18,993,146 |
Echocardiographic and clinical risk factors for atrial fibrillation in hypertensive patients with ischemic stroke. | Atrial fibrillation (AF) is a common cause of ischemic stroke. Because anticoagulation can prevent many of these strokes, identifying patients with occult intermittent AF is important. Hypertension is a common precursor of stroke and AF. Prolonged nonselective electrocardiographic monitoring of patients after ischemic ... | 18,993,153 |
Doppler-catheter discrepancies in patients with bileaflet mechanical prostheses or bioprostheses in the aortic valve position. | The aims of the present study were to investigate in vivo Doppler-catheter discrepancies in aortic bileaflet mechanical and stented biologic valves and evaluate whether these can be predicted using Doppler echocardiography. Results of in vitro studies of bileaflet mechanical valves suggested overestimation using Dopple... | 18,993,160 |
The relationship of endometriosis and ovarian malignancy: a review. | To review the malignant potential of endometriosis based on epidemiologic, histopathologic, and molecular data. Literature review. The pathogenesis of endometriosis remains unclear. The histopathologic development of endometriosis has undergone long-term investigation. Studies have confirmed histologic transition from ... | 18,993,168 |
Diabetic nephropathy: important pathophysiologic mechanisms. | With the global epidemic of type 2 diabetes mellitus, diabetes has become the leading cause of end stage renal failure (ESRF) in most Western countries. Approximately 20-30% of all diabetic subjects will develop evidence of diabetic nephropathy, which represents a continuum from microalbuminuria, to overt nephropathy o... | 18,994,672 |
Hand hygiene compliance monitoring: current perspectives from the USA. | Monitoring hand hygiene compliance and providing healthcare workers with feedback regarding their performance are considered integral parts of a successful hand hygiene promotion program. Direct observation of care providers by trained personnel is currently considered the gold standard. Advantages include the ability ... | 18,994,674 |
[Plastic bronchitis: report of a pediatric case]. | Plastic bronchitis (PB) is a rare disease, characterized by the formation of obstructive branching airways tracheobronchial casts. Commonly, PB often complicates the course of cardiac or respiratory disorders. The occurrence of PB before manifestation of the underlying respiratory disease is unusual. We report on the c... | 18,995,152 |
Hope, optimism, and self-care among Better Breathers Support Group members with chronic obstructive pulmonary disease. | The objective of this study was to determine the levels of hope, optimism, and self-care of persons with chronic obstructive pulmonary disease (COPD) who attend community-based Better Breathers Support Group (BBSG) meetings. A convenience sample of 68 BBSG members from 14 groups in three southeastern states participate... | 18,995,163 |
A randomized clinical trial of the clinical effects of enhanced heart failure monitoring using a computer-based telephonic monitoring system in older minorities and women. | Prior studies suggest that disease management programs may be effective in improving clinical outcomes in patients with heart failure (HF). However, the use of these programs in settings with limited sources and among diverse population is not know. Thus the present study was designed to assess the impact of a computer... | 18,995,174 |
Activation of inducible NOS in peripheral vessels and outcomes in heart failure patients. | Activation of inducible nitric oxide synthase (iNOS) has been reported in congestive heart failure (CHF) conditions. However, it is unknown whether activation of iNOS affects prognosis of CHF patients. We prospectively studied the influence of activation of iNOS in the forearm on the outcome of CHF patients. Forearm bl... | 18,995,176 |
Serial sampling of ST2 predicts 90-day mortality following destabilized heart failure. | To prospectively determine the prognostic utility of serial sampling of the interleukin-1 receptor family member, ST2, for predicting 90-day mortality in patients with heart failure (HF) admitted to a Veteran Affairs Medical Center. A total 150 patients hospitalized with acutely destabilized HF were followed at the Vet... | 18,995,177 |
Epithelioid smooth muscle tumors of the uterus do not express CD1a: a potential immunohistochemical adjunct in their distinction from uterine perivascular epithelioid cell tumors. | Uterine epithelioid smooth muscle tumors and uterine perivascular epithelioid cell tumors (PEComas) are known to display such a substantial overlap in morphologic and immunophenotypic characteristics that the existence of the latter as a distinct clinicopathologic entity at this location has been called into question. ... | 18,995,203 |
Understanding synapses: past, present, and future. | Classical physiological work by Katz, Eccles, and others revealed the central importance of synapses in brain function, and characterized the mechanisms involved in synaptic transmission. Building on this work, major advances in the past two decades have elucidated how synapses work molecularly. In the present perspect... | 18,995,821 |
The fast-growing business of SUMO chains. | Like ubiquitin itself, the small ubiquitin-related modifier SUMO can form polymeric chains on many of its targets. Recent analyses have provided evidence for a number of distinct biological functions of the poly-SUMO signal. | 18,995,828 |
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. | The Fanconi anemia (FA) pathway is implicated in DNA repair and cancer predisposition. Central to this pathway is the FA core complex, which is targeted to chromatin by FANCM and FAAP24 following replication stress. Here we show that FANCM and FAAP24 interact with the checkpoint protein HCLK2 independently of the FA co... | 18,995,830 |
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. | In mitosis, the spindle checkpoint detects a single unattached kinetochore, inhibits the anaphase-promoting complex or cyclosome (APC/C), and prevents premature sister chromatid separation. The checkpoint kinase Bub1 contributes to checkpoint sensitivity through phosphorylating the APC/C activator, Cdc20, and inhibitin... | 18,995,837 |
Why did the frequency of palatine torus increase in the ancient Anatolian populations? | The frequency of the palatine torus varies in various populations from different regions of the world. In this study, the change of frequency of palatine torus is examined using 387 skulls from 12 different ancient Anatolian populations in various periods ranging from the Early Bronze Age to the first quarter of the 20... | 18,995,851 |
Acute phase protein levels in pregnancy and oestrus cycle in bitches. | The purpose of this study was to evaluate the acute phase protein (serum amyloid A, C-reactive protein, haptoglobin, ceruloplasmin and fibrinogen) profiles in pregnant dogs as well as bitches at various stages of the estrus cycle and to verify possible relationship(s) among the APPs profile and hormonal status. A total... | 18,995,874 |
Impacts of weathered tire debris on the development of Rana sylvatica larvae. | Highway runoff has the potential to negatively impact receiving systems including stormwater retention ponds where highway particulate matter can accumulate following runoff events. Tire wear particles, which contain about 1% Zn by mass, make up approximately one-third of the vehicle derived particulates in highway run... | 18,995,883 |
Synergistic cytotoxicity of interferonalpha-2b and interleukin-2 in combination with PBMC against ovarian cancer: development of an experimental model for cellular therapy. | Current therapies for ovarian cancer (OC) patients have a modest impact on long-term survival justifying the need for novel treatment strategies. We developed in vitro and in vivo systems to test the effects of cytokines in combination with peripheral blood mononuclear cells (PBMC) on OC cells. Two OC cell-lines were t... | 18,995,891 |
Improved quality of sex-sorted sperm: a prerequisite for wider commercial application. | To date the only successful method to sort sperm into X- and Y-chromosome-bearing populations is the Beltsville Sperm Sexing Technology. Fertility results continue to be variable even though the technology has been used in a commercial setting for nearly a decade. This is at least partly due to the reduced lifespan of ... | 18,995,893 |
Human fetal membranes: a source of stem cells for tissue regeneration and repair? | The ability of stem cells to differentiate into multiple cell lineages has ushered in exciting possibilities for stem cell based therapies that would be used to regenerate and repair damaged tissues and organs. Stem cells isolated from the embryo, fetus, adult and also the umbilical cord and placenta are being widely t... | 18,995,896 |
Second myeloablative allogeneic stem cell transplantation (SCT) using cord blood for leukemia relapsed after initial allogeneic SCT. | There are many reports of second allogeneic stem cell transplantation (allo-SCT) using cord blood (CB) for graft failure after initial allo-SCT. However, the efficacy of second allo-SCT using CB for patients with leukemia relapsed after initial allo-SCT is unknown. We report the results of second allo-SCT using CB in s... | 18,995,897 |
Quantitative structure-property relationship studies for direct photolysis rate constants and quantum yields of polybrominated diphenyl ethers in hexane and methanol. | The direct photolysis of 18 individual polybrominated diphenyl ethers (PBDEs) substituted with 1-7 bromine atoms was investigated in hexane and methanol under UV irradiation. Based on the determined photolysis rate constants (k(p)) and calculated quantum yields (Phi), four quantitative structure-property relationship (... | 18,995,905 |
Mutagenicity and genotoxicity of coal fly ash water leachate. | Fly ash is a by-product of coal-fired electricity generation plants. The prevalent practice of disposal is as slurry of ash and water to storage or ash ponds located near power stations. This has lain to waste thousands of hectares of land all over the world. Since leaching is often the cause of off-site contamination ... | 18,995,907 |
Health risk by inhalation of PM2.5 in the metropolitan zone of the City of Mexico. | The study assessed the risk to the health of the inhabitants of the metropolitan zone of the City of Mexico posed by the chemical elemental contamination present in PM(2.5) particles. PIXE (particle induced X-ray emission) analysis of particles identified 18 elements, thereby achieving an elemental characterization. In... | 18,995,908 |
Water Babies: an evolutionary parable. | The nineteenth-century Anglican theologian Charles Kingsley was immediately impressed by Darwin's Origin of Species. Whilst many in Victorian Britain reacted against the idea of natural selection, Kingsley saw in the contingency of selection a divinely ordained imperative for human endeavour, not least the pursuit of s... | 18,995,909 |
Combined hamartoma of the retina and retinal pigment epithelium in 77 consecutive patients visual outcome based on macular versus extramacular tumor location. | To evaluate visual outcome of eyes with combined hamartoma of the retina and retinal pigment epithelium (RPE). Noncomparative case series. Seventy-nine eyes of 77 patients. Retrospective chart review. Visual outcome. The presenting symptoms were decreased vision (n = 32; 40%), strabismus (n = 22; 28%), both (n = 3; 4%)... | 18,995,912 |
Association between circadian rhythm of blood pressure and glucose tolerance status in normotensive, non-diabetic subjects. | To examine whether circadian rhythm of blood pressure (BP) is associated with glucose tolerance status in normotensive, non-diabetic subjects. A cross-sectional study recruited normotensive and non-diabetic subjects, aged 35-79 years. A 75 g oral glucose tolerance test (OGTT) and 24-h ambulatory blood pressure monitori... | 18,995,921 |
Long-term effects of lead poisoning on bone mineralization in vultures exposed to ammunition sources. | Long-lived species are particularly susceptible to bioaccumulation of lead in bone tissues. In this paper we gain insights into the sublethal effects of lead contamination on Egyptian vultures (Neophron percnopterus). Our approach was done on the comparison of two populations (Canary Islands and Iberian Peninsula) diff... | 18,995,938 |
Neighborhood effects on birthweight: an exploration of psychosocial and behavioral pathways in Baltimore, 1995--1996. | Neighborhood characteristics have been proposed to influence birth outcomes through psychosocial and behavioral pathways, yet empirical evidence is lacking. Using data from an urban, low-income sample, this study examined the impact of the neighborhood environment on birthweight and evaluated mediation by psychosocial ... | 18,995,941 |
Accuracy of CA 125 in the diagnosis of ovarian tumors: a quantitative systematic review. | A quantitative systematic review was performed to estimate the accuracy of CA 125 assay in the diagnosis of ovarian tumors. Studies that evaluated CA 125 levels for the diagnosis of ovarian tumors and compared them with paraffin-embedded sections as the diagnostic standard were included. Seventeen studies were analyzed... | 18,995,946 |
Electron microscopy localization and characterization of functionalized composite organic-inorganic SERS nanoparticles on leukemia cells. | We demonstrate the use of electron microscopy as a powerful characterization tool to identify and locate antibody-conjugated composite organic-inorganic nanoparticle (COINs) surface enhanced Raman scattering (SERS) nanoparticles on cells. U937 leukemia cells labeled with antibody CD54-conjugated COINs were characterize... | 18,995,965 |
C2H2 interaction with Ni nanocrystals: towards a better understanding of carbon nanotubes nucleation in CVD synthesis. | We present a study of the early stages of carbon nanotubes nucleation in CVD synthesis by combining field ion/electron emission microscopy (FIM/FEM) and atom-probe investigation (AP) of the nickel-carbon interaction. Acetylene decomposition on Ni tips at 873K is observed to induce additional step formation on an initia... | 18,995,966 |
A follow-up investigation on the quality of medical documents from examinations of Basque incommunicado detainees: the role of the medical doctors and national and international authorities in the prevention of ill-treatment and torture. | According to the United Nations and the European Committee for the Prevention of Torture (CPT), torture and ill-treatment continues to be a problem during incommunicado detentions in Spain. CPT has visited Spain and published recommendations for improvements of preventive medical examinations. However, no scientific as... | 18,995,973 |
[Childhood medulloblastoma]. | Medulloblastoma is one of the most common malignant childhood brain tumors. It is a primitive neuroectodermal tumor (PNET) and predominantly arises in the cerebellum and 4th ventricle. Most cases of medulloblastoma are sporadic, but some predisposition syndromes are known, such as SUFU and Gorlin syndromes. Most often ... | 18,995,998 |
Visual feedback training improves postural adjustments associated with moving obstacle avoidance in elderly women. | The study examined the impact of visually guided weight shifting (WS) practice on the postural adjustments evoked by elderly women when avoiding collision with a moving obstacle while standing. Fifty-six healthy elderly women (70.9+/-5.7 years, 87.5+/-9.6 kg) were randomly assigned into one of three groups: a group tha... | 18,996,012 |
C-2-aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors. | Several novel thiourea derivatives of the NNRTI HI-236 substituted at the C-2 oxygen of the phenyl ring have been synthesized and evaluated for their inhibitory activity against HIV-1 (IIIB) replication in MT-2 cell cultures. The compounds were synthesized in order to fine-tune the activity of HI-236 as well as to gain... | 18,996,020 |
Initial experience with 'inverted U' staged buccal mucosa graft (bracka) for hypospadias repair. | To describe a modification of the Bracka procedure ('inverted U'), used to enlarge the graft and diminish the risk of graft contracture compromising the subsequent urethral reconstruction. Inverted U Bracka procedure was performed in 10 children in whom previous hypospadias correction had failed. The surgical steps are... | 18,996,051 |
REMOVED: In defense of King et al.: the validity of manual examination in assessing patients with neck pain. | This article has been removed consistent with Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). The Publisher apologizes for any inconvenience this may cause. | 18,996,053 |
The use of proteome similarity for the qualitative and quantitative profiling of reperfused myocardium. | An LC-MS-based approach is presented for the identification and quantification of proteins from unsequenced organisms. The method relies on the preservation of homology across species and the similarity in detection characteristics of proteomes in general. Species related proteomes share similarity that progresses from... | 18,996,061 |
Influence of clotting time on the protein composition of serum samples based on LC-MS data. | Many large, disease-related biobanks of serum samples have been established prior to the widespread use of proteomics in biomarker research. These biobanks may contain relevant information about the disease process, response to therapy or patient classifications especially with respect to long-term follow-up that is ot... | 18,996,063 |
What determines the need to morcellate the uterus during total laparoscopic hysterectomy? | To identify factors associated with the need to perform uterine morcellation during total laparoscopic hysterectomy (TLH). A secondary aim was to establish new cut-offs based on uterine weight for the probability of morcellation. Prospective observational study (Canadian Task Force Classification II-2). Tertiary referr... | 18,996,059 |
Capability of human umbilical cord blood progenitor-derived endothelial cells to form an efficient lining on a polyester vascular graft in vitro. | One of the goals of vascular tissue engineering is to create functional conduits for small-diameter bypass grafting. The present biocompatibility study was undertaken to check the ability of cord blood progenitor-derived endothelial cells (PDECs) to take the place of endothelial cells in vascular tissue engineering. Af... | 18,996,071 |
Surgical debridement, vacuum therapy and pectoralis plasty in poststernotomy mediastinitis. | In cardiac surgery poststernotomy mediastinitis continues to be a serious cause of morbidity and mortality. We report our experience with vacuum-assisted closure (VAC) therapy followed by reconstruction with M. pectoralis muscle flaps as treatment for deep sternal wound infections. Our group performed a retrospective a... | 18,996,074 |
Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1. | In the pituitary, the transition from proliferating progenitor cell into differentiated hormone producing cell is carefully regulated in a time-dependent and spatially-restricted manner. We report that two targets of Notch signaling, Hes1 and Prop1, are needed to maintain progenitors within Rathke's pouch and for the r... | 18,996,108 |
WITHDRAWN: Gastroenterology Turns 65. | The publisher regrets that this article is an accidental duplication of an article that has already been published, doi:10.1053/j.gastro.2008.10.040. The duplicate article has therefore been withdrawn. | 18,996,121 |
Redox properties of the A-domain of the HMGB1 protein. | The High Mobility Group B1 (HMGB1) protein plays important roles in both intracellular (reductive) and extracellular (oxidative) environments. We have carried out quantitative investigations of the redox chemistry involving Cys22 and Cys44 of the HMGB1 A-domain, which form an intramolecular disulfide bond. Using NMR sp... | 18,996,119 |
Beckmann reactions of steroidal spirocyclic oximes derived from the 16beta,23:23,26-diepoxy-22-oxo moiety. | The Beckmann rearrangement of the syn and anti isomers of the spirocyclic oxime derived from a 16beta,23:23,26-diepoxy-5beta-cholestan-22-one was studied. Whereas the anti isomer always follows the Beckmann fragmentation course, the syn isomer, depending on the reaction conditions, follows the normal Beckmann rearrange... | 18,996,137 |
An exact steady state solution of Fisher's geometric model and other models. | Because nearly neutral substitutions are thought to contribute substantially to molecular evolution, and much of our insight about the workings of nearly neutral evolution relies on theory, solvable models of this process are of particular interest. Here, I present an analytical method for solving models of nearly neut... | 18,996,138 |
Molecular characterization of a sodium channel gene from the Silkworm Bombyx mori. | The voltage-gated sodium channel mediates the rapid rising phase of action potentials in almost all excitable cells and is a molecular target of a variety of neurotoxins including pyrethroid insecticides. Most studies have focused on the expression of sodium channel genes in the adult stage, information on other develo... | 18,996,195 |
The future (or lack of future) of personalized prescription in psychiatry. | Rapid technological advances in genetics have created conceptual chaos regarding the genetics of drug response. Terms for differing concepts are used interchangeably: pharmacogenetics with pharmacogenomics, personalized medicine with personalized prescription. Biomarker has many definitions. The author prefers the conc... | 18,996,200 |
Anti-cancer effect of Cassia auriculata leaf extract in vitro through cell cycle arrest and induction of apoptosis in human breast and larynx cancer cell lines. | The in vitro anti-cancer effect of Cassia auriculata leaf extract (CALE) was evaluated in human breast adenocarcinoma MCF-7 and human larynx carcinoma Hep-2 cell lines. CALE preferentially inhibited the growth of both the cell lines in a dose-dependent manner with IC(50) values of 400 and 500 microg for MCF-7 and Hep-2... | 18,996,213 |
Effects of testosterone therapy on muscle performance and physical function in older men with mobility limitations (The TOM Trial): design and methods. | The TOM study is the first, single-site, placebo-controlled, randomized clinical trial designed to comprehensively determine the effects of testosterone administration on muscle strength and physical function in older men with mobility limitations. A total of 252 community dwelling individuals aged 65 and older with lo... | 18,996,225 |
Sources of sacroiliac region pain: insights gained from a study comparing standard intra-articular injection with a technique combining intra- and peri-articular injection. | To present evidence supporting the existence of extra-articular sources for sacroiliac region pain and to present evidence that intra-articular anesthetic blockade may underestimate the true prevalence of sacroiliac region pain. Retrospective review of 2 large case series comparing patient responses to intra-articular ... | 18,996,232 |
Shoulder ultrasound abnormalities, physical examination findings, and pain in manual wheelchair users with spinal cord injury. | To investigate the presence of ultrasound (US) abnormalities in manual wheelchair users with spinal cord injury (SCI) using a quantitative Ultrasound Shoulder Pathology Rating Scale (USPRS). To investigate physical examination (PE) findings using a quantitative Physical Examination of the Shoulder Scale (PESS), and to ... | 18,996,236 |
Iatrogenic femoral artery pseudoaneurysms--a review of current methods of diagnosis and treatment. | The common femoral artery is commonly used as arterial access for a wide range of radiological and cardiological procedures. Pseudoaneurysm formation is the most common arterial complication of femoral artery catheterization, and is diagnosed using colour Doppler ultrasound. Ultrasound-guided thrombin injection has rep... | 18,996,260 |
Evaluation of multidetector computed tomography urography and ultrasonography for diagnosing bladder cancer. | To evaluate and compare the diagnostic accuracy of multidetector computed tomography urography (CTU) and ultrasonography (US) for diagnosing bladder cancer. A consecutive series of 143 patients over 40-years of age, presenting with macroscopic haematuria and without urinary tract infection underwent same-day CTU, US, a... | 18,996,261 |
Clinical utility of 99mTc-labeled ubiquicidin 29-41 antimicrobial peptide for the scintigraphic detection of mediastinitis after cardiac surgery. | Previous studies demonstrated that (99m)Tc-labeled-ubiquicidin 29-41 ((99m)Tc-UBI 29-41) imaging is an accurate method for detection of bacterial infections. This study was conducted to evaluate the clinical use of (99m)Tc-UBI 29-41 for detection of mediastinitis after cardiac surgery. Thirteen patients with suspected ... | 18,996,290 |
Identification of placental leucine aminopeptidase and triton-slowed aminopeptidase N in serum of pregnant women. | Previously, we found characteristic triton-slowed bands of aminopeptidase N (APN) in cholestatic serum by triton-polyacrylamide gel electrophoresis (triton-PAGE) [Makoto Kawai, Yukichi Hara, Triton-polyacrylamide gel electrophoresis and leucine aminopeptidase activity staining detect Triton-slowed bands including high-... | 18,996,364 |
A strategy for screening an inhibitor of viral silencing suppressors, which attenuates symptom development of plant viruses. | To find out whether we can control plant virus diseases by blocking viral RNA silencing suppressors (RSSs), we developed a strategy to screen inhibitors that block the association of RSSs with siRNAs using a surface plasmon resonance assay. The screened chemicals were tested in competition with RSSs for binding to siRN... | 18,996,375 |
Rapid characterization of binding specificity and cross-reactivity of antibodies using recombinant human protein arrays. | Antibodies are routinely used as research tools, in diagnostic assays and increasingly as therapeutics. Ideally, these applications require antibodies with high sensitivity and specificity; however, many commercially available antibodies are limited in their use as they cross-react with non-related proteins. Here we de... | 18,996,391 |
Can morphing methods predict intermediate structures? | Movement is crucial to the biological function of many proteins, yet crystallographic structures of proteins can give us only a static snapshot. The protein dynamics that are important to biological function often happen on a timescale that is unattainable through detailed simulation methods such as molecular dynamics ... | 18,996,395 |
Redesigned immunization card and center-based education to reduce childhood immunization dropouts in urban Pakistan: a randomized controlled trial. | In Pakistan during 2000-2004, about 11-13% of children who received the first dose of diphtheria-pertussis-tetanus (DPT1) failed to complete its third dose (DPT3). We assessed the effect of a redesigned immunization card and center-based education to mothers on DPT3 completion. We enrolled 1500 mother-child units at DP... | 18,996,423 |
The distribution of gamma-hydroxybutyrate-induced Fos expression in rat brain: comparison with baclofen. | gamma-Hydroxybutyrate (GHB) is a euphoric, prosocial and sleep inducing drug that binds with high affinity to its own GHB receptor site and also more weakly to GABA(B) receptors. GHB is efficacious in the treatment of narcolepsy and alcoholism, but heavy use can lead to dependence and withdrawal. Many effects of GHB (s... | 18,996,447 |
Hamster exhibits major differences in organ-specific metabolism of the esophageal carcinogen N-nitrosodiethylamine. | Nitrosamines are carcinogens that require metabolic activation by CYP enzymes in order to exert their carcinogenic effect. Species differences exist in their esophageal carcinogenic potency, with the rat being the most sensitive and the Syrian hamster a resistant species. In the latter, the liver is the main target org... | 18,996,452 |
Poly(ethylene glycol)-mesalazine conjugate for colon specific delivery. | Chronic inflammatory bowel diseases (IBDs) are still waiting for improved and innovative therapeutic treatments, which can overcome the limits of the current approaches. Since IBDs affect mainly the lower tract of the intestine, a localized therapy in the colon tract will avoid most of the problems caused by systemic o... | 18,996,458 |
Activation of transcription factors and gene expression by oxidized low-density lipoprotein. | It is well recognized that oxidized LDL (OxLDL) plays a crucial role in the initiation and progression of atherosclerosis. Many biological effects of OxLDL are mediated through signaling pathways, especially via the activation of transcription factors, which in turn stimulate the expression of genes involved in the inf... | 18,996,472 |
Early treatment with Lactobacillus delbrueckii strain induces an increase in intestinal T-cells and granulocytes and modulates immune-related genes of larval Dicentrarchus labrax (L.). | Lactobacillus delbrueckii ssp. delbrueckii (AS13B), isolated from the gut of adult Dicentrarchus labrax, was administered live to developing sea bass using rotifers and Artemia as live carriers. Immune-related gene transcripts were quantified in post-larvae at day 70 post-hatch (ph) and histology, electron microscopy a... | 18,996,487 |
Functional brain correlates of social and nonsocial processes in autism spectrum disorders: an activation likelihood estimation meta-analysis. | Functional neuroimaging studies of autism spectrum disorders (ASD) have examined social and nonsocial paradigms, although rarely in the same study. Here, we provide an objective, unbiased survey of functional brain abnormalities in ASD, related to both social and nonsocial processing. We conducted two separate voxel-wi... | 18,996,505 |
Asymmetric epoxidation of unfunctionalized alkenes catalyzed by sugar moiety-modified chiral salen-Mn(III) complexes. | Several chiral Schiff-base ligands with sugar moieties at C-3 (3') or C-5 (5') of salicylaldehyde were synthesized from reaction of salicylaldehyde derivatives with diamine. These ligands coordinated with Mn(III) to afford the corresponding chiral salen-Mn(III) complexes characterized by FT-IR, MS, and elementary analy... | 18,996,511 |
Relationship of handgrip strength with anthropometric and body composition variables in prepubertal children. | The purpose of the present study was to examine the relationship of handgrip strength with basic anthropometric variables, hand anthropometric variables, total body and hand composition, total body and hand bone mineral density (BMD) and bone mineral content (BMC) in prepubertal children aged between 8 and 11 years (n=... | 18,996,520 |
Efficacy and safety of ABT-335 (fenofibric acid) in combination with rosuvastatin in patients with mixed dyslipidemia: a phase 3 study. | To evaluate a new formulation of fenofibric acid (ABT-335) co-administered with 2 doses of rosuvastatin in patients with mixed dyslipidemia. In a phase 3, multicenter, randomized, double-blind, active-controlled study, a total of 1445 patients with LDL-C>or=130 mg/dL, TG>or=150 mg/dL, and HDL-C<40 mg/dL (<5... | 18,996,523 |
Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. | Nicotinamide N-methyltransferase (NNMT) catalyses the conversion of nicotinamide to 1-methylnicotinamide and plays an important role in hepatic detoxification reactions. Here we show that, in addition to the liver, 3T3-L1 adipocytes as well as human and murine adipose tissue explants express high amounts of enzymatical... | 18,996,527 |
A wearable system for pre-impact fall detection. | Unique features of body segment kinematics in falls and activities of daily living (ADL) are applied to make automatic detection of a fall in its descending phase, prior to impact, possible. Fall-related injuries can thus be prevented or reduced by deploying fall impact reduction systems, such as an inflatable airbag f... | 18,996,529 |
Brain activities associated with gaming urge of online gaming addiction. | The aim of this study was to identify the neural substrates of online gaming addiction through evaluation of the brain areas associated with the cue-induced gaming urge. Ten participants with online gaming addiction and 10 control subjects without online gaming addiction were tested. They were presented with gaming pic... | 18,996,542 |
Electro-Fenton degradation of synthetic dyes. | The electrochemical removal of a synthetic solution containing 120mgL(-1) of alizarin red has been studied by electro-Fenton process using a gas-diffusion cathode to produce in situ hydrogen peroxide by oxygen reduction. The effect of operating conditions such as Fe(2+) concentration, applied current, solution pH and t... | 18,996,554 |
Controlled remineralization of enamel in the presence of amelogenin and fluoride. | Reconstructing enamel-like structures on teeth have been an important topic of study in the material sciences and dentistry. The important role of amelogenin in modulating the mineralization of organized calcium phosphate crystals has been previously reported. We used amelogenin and utilized a modified biomimetic depos... | 18,996,587 |
Medication treatment perceptions, concerns and expectations among depressed individuals with Type I Bipolar Disorder. | Subjective experience of illness affects outcomes among populations with bipolar disorder (BD). This cross-sectional study combined qualitative and quantitative approaches to evaluate perceived treatment effects, concerns and expectations among 90 individuals with BD. Adults with Type I BD, mean age 36.6 years, 51% wom... | 18,996,600 |
Radiotherapy to the chest wall following mastectomy for node-negative breast cancer: a systematic review. | Although nodal status is the major determinant of risk of locoregional relapse (LRR), other factors also contribute, and these assume a greater significance for those with node-negative breast cancer. Previous reviews of post-mastectomy radiotherapy have included studies using radiotherapy techniques or doses no longer... | 18,996,609 |
Necessary organizational changes according to Burke-Litwin model in the head nurses system of management in healthcare and social welfare institutions - the Slovenia experience. | To discover which changes should be implemented in the system of head nursing management in Slovenian healthcare institutions and social welfare institutions. The questionnaire was distributed to 155 head nurses of Slovenian hospitals, primary healthcare centres and social welfare institutions. The Burke-Litwin organiz... | 18,996,612 |
Photolytic degradation of polybromodiphenyl ethers under UV-lamp and solar irradiations. | Polybromodiphenyl ethers (PBDEs) are widely used flame retardant additives and have been mainly used in polymers for many plastic and electronic products. PBDEs have been found to bioaccumulate in both aquatic and terrestrial ecosystems and even human bodies. The technical product with the highest use is decabrominated... | 18,996,643 |
Towards the clinical application of X-ray phase contrast imaging. | Synchrotron-based propagation-based imaging, a type of phase contrast imaging, produces better soft tissue image contrast than conventional radiography. To determine whether the technique is directly transferable to the clinical environment for routine diagnostic or screening imaging, a micro-focus (100 microm spot-siz... | 18,996,661 |
Endovascular repair or medical treatment of acute type B aortic dissection? A comparison. | The aim of this retrospective study was to compare the outcome of thoracic endovascular aortic repair (TEVAR) to that of medical therapy in patients with acute type B aortic dissection (TBD). From July 1996 to April 2008, 88 patients presenting with acute TBD underwent either TEVAR (group A, n=38) or medical therapy (g... | 18,996,662 |
The development of methodology for clinical measurement of 5-lipoxygenase pathway intermediates from human peripheral blood mononuclear cells. | Recent studies have shown a correlation between 5-lipoxygenase (5-LO) pathway up-regulation and cardiovascular risk. Despite the existence of several assays for products of the 5-LO pathway, a reliable method for clinical determination of 5-LO activity remains to be established. In the present communication, we report ... | 18,996,667 |
Prevalence of hepatitis C, hepatitis B, and human immunodeficiency virus in a Grand Rapids, Michigan emergency department. | The objective of this study is to provide updated prevalence information on hepatitis C, hepatitis B, and human immunodeficiency virus (HIV) among patients in a high-volume emergency department (ED) located in a medium-sized, Midwestern city. This study provides updated information regarding the prevalence of the blood... | 18,996,668 |
Isolated, spontaneous superior mesenteric and celiac artery dissection: case report and review of literature. | Spontaneous, isolated dissection of the superior mesenteric artery (SMA) and celiac artery (CA) is rare. Although there are known risk factors, there is no particular mechanism that is common to vascular dissections. The objectives of this study were to review the current literature on diagnosis and treatment of isolat... | 18,996,673 |
Comparison of the interfacial properties of Eugenia uniflora and Triticum vulgaris lectins. | We have investigated the interfacial and dielectric properties of EuniSL, a recently purified lectin obtained from seeds of Eugenia uniflora (EuniSL), through surface pressure (Pi) and surface potential (DeltaV) measurements of its floating monolayers at the 2.0<pH<9.0 range, and compared the corresponding result... | 18,996,683 |
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