title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Mild systemic inflammation has a neuroprotective effect after stroke in rats. | Stroke is accompanied by a strong inflammatory reaction in the brain. Periodontal disease is a chronic local infection which causes a systemic low grade inflammation. We hypothesized that a mild systemic inflammatory reaction as caused by periodontal disease prior to stroke onset, may exert a neuroprotective effect in ... | 18,991,656 |
Clinical potential of minocycline for schizophrenia. | Minocycline, an antibiotic of the tetracycline family, has been shown to display neurorestorative or neuroprotective properties in various models of neurodegenerative diseases. In particular, it has been shown to delay motor alterations, inflammation and apoptosis in models of Huntington's disease, amyotrophic lateral ... | 18,991,666 |
Cardiac metabolism in diabetes mellitus. | Diabetes mellitus is one of the most common chronic illnesses throughout the world. Diabetic cardiomyopathy is a specific syndrome, consisting of cardiomegaly, left ventricular dysfunction, electrical remodeling of the ventricle, and symptoms of congestive heart failure, that is seen in diabetic patients in the absence... | 18,991,669 |
Imaging of tumor hypoxia to predict treatment sensitivity. | Non-invasive detection of tumor hypoxia using radiolabeled 2-nitroimidazoles has been a major effort during the last two decades. Recent years have witnessed the introduction of several new compounds which are chemically related to [(18)F]fluoromisonidazole (FMISO) but show slight but distinct differences in biodistrib... | 18,991,711 |
PET imaging of steroid receptor expression in breast and prostate cancer. | The vast majority of breast and prostate cancers express specific receptors for steroid hormones, which play a pivotal role in tumor progression. Because of the efficacy of endocrine therapy combined with its relatively mild side-effects, this intervention has nowadays become the treatment of choice for patients with a... | 18,991,716 |
Synthesis of chiral 3-methyl- and 3-methyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline and prevention of MPP+ -induced cytotoxicity. | The chemical structure of selegiline, a commercially available drug for Parkinson's disease (PD), resembles that of 1,2,3,4-tetrahydroisoquinoline (TIQ), an endogenous parkinsonism-inducing compound. In the present study, we evaluated the direct cytotoxicity of (R)- and (S)-3-methyl-TIQ (3-MeTIQ) and (R)- and (S)-3-met... | 18,991,736 |
2-Arylbenzimidazoles as antiviral and antiproliferative agents. Part 1. | Being involved in an anti-Flaviviridae Project, and because of the role played by benzimidazole derivatives as promising inhibitors of the HCV helicase and RNA polymerase, as well as of the Zn finger transcription factor, we synthesized a new series of 2-arylbenzimidazoles and evaluated them for antiviral activity, as ... | 18,991,746 |
Therapeutic targeting of g-protein coupled receptor-mediated epidermal growth factor receptor transactivation in human glioma brain tumors. | The epidermal growth factor receptor (EGFR) is the main tyrosine kinase receptor dysregulated or overexpressed in brain cancer types and its expression is directly correlated with tumor malignancy and unfavorable prognosis. Recently, the availability of endogenous EGFR ligands has been reported to be also regulated ind... | 18,991,757 |
Structural fragments in protein model refinement. | We survey a method that uses patterns of residue packing in known protein structures to refine structural models. The method can be used to refine models that include only one coordinate point per residue (C(alpha)) and is not dependent on homology. We demonstrate that the method improves both decoy and CASP7 target mo... | 18,991,773 |
[Effect of strict glycemic control on clinical state and course of the disease in patients with chronic heart failure and type II diabetes mellitus. Results of the REMBO "rational effective multicomponent therapy in the struggle against diabetes mellitus in patients with congestive heart failure" study]. | With the aim to investigate influence of glycemic control on clinical state and course of disease, renal function, and neurohormonal profile of patients with chronic heart failure (CHF) and type 2 diabetes mellitus (DM) we studied 81 patients with NYHA functional class (FC) II - III CHF, left ventricular ejection fract... | 18,991,816 |
[Efficacy of the use of a sour milk product enriched with phytosterols in diet therapy of patients with cardiovascular diseases]. | We studied effect of antiatherogenic diet with inclusion of a sour milk product Danacor enriched with phytosterols on clinical and biochemical parameters of patients with cardiovascular diseases. Results of the study showed that antiatherogenic diet with phytosterols facilitated improvement of clinical status, anthropo... | 18,991,820 |
[Possibility of optimization of hypertension control in operators of trains on the basis of automatic system of pre-work examination]. | We have investigated possibility of the use of automatic systems for controlling arterial pressure in a specific occupational group - train\'s operators. This method is based on measurement and analysis of parameters of arterial pressure and pulse during pre-work (pre-haul) medical examinations of train\'s operators wi... | 18,991,833 |
[Identification of pacemaker cells from atrial natriuretic peptide expressing embryonic stem cells]. | At present there exists a limited understanding of mechanisms of differentiation and specialization of cardiac conduction system in mammals. For characterization of its development and differentiation on early stages we used as experimental model murine embryonic stem cells expressing enhanced green fluorescent protein... | 18,991,834 |
Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population. | Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamph... | 18,991,849 |
Methamphetamine-induced early increase of IL-6 and TNF-alpha mRNA expression in the mouse brain. | The mechanisms by which methamphetamine (METH) causes neurotoxicity are not well understood. Recent studies have suggested that METH-induced neuropathology may result from a multicellular response in which glial cells play a prominent role, and so it is plausible to suggest that cytokines may participate in the toxic e... | 18,991,854 |
Analysis of single, purified inclusions as a novel approach to understand methamphetamine neurotoxicity. | A variety of neurodegenerative diseases leading to movement disorders such as Parkinson's disease (PD) are characterized by neuronal inclusions. Despite evidence of the presence of these intrusions, these intracellular bodies have been poorly investigated because of the technical limits of reproducing them in experimen... | 18,991,863 |
Influence of chronic exercise on the amphetamine-induced dopamine release and neurodegeneration in the striatum of the rat. | The aim of this study was to verify the effect of chronic exercise on the striatal dopamine (DA) outflow induced by low and high single doses of amphetamine (AMPH), and verify the existence of an exercise protective role on neurodegeneration. Adult male Sprague-Dawley rats were randomly separated into six groups: chron... | 18,991,868 |
Methamphetamine changes NMDA and AMPA glutamate receptor subunit levels in the rat striatum and frontal cortex. | Methamphetamine (METH) is a powerful psychostimulant whose noxious effects depend largely on the pattern of abuse. METH-induced glutamate release may overactivate N-methyl-d-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (NMDAR and AMPAR, respectively) causing excitotoxicity. In the b... | 18,991,869 |
Crucial role of acetaldehyde in alcohol activation of the mesolimbic dopamine system. | Ethyl alcohol (EtOH), the main psychoactive ingredient of alcoholic drinks, is widely considered responsible for alcohol abuse and alcoholism through its positive motivational properties, which depend, at least partially, on the activation of the mesolimbic dopaminergic system. On the other hand, acetaldehyde (ACD), Et... | 18,991,876 |
Defining "neuroinflammation". | Neuroinflammation is a hot topic in contemporary neuroscience. A relatively new open-access journal, the Journal of Neuroinflammation, focuses on this field. As another example, abstracts to the 2007 Annual Meeting of the Society for Neuroscience could be submitted in several subcategories of neuroinflammation, a stron... | 18,991,877 |
Screening for marijuana and cocaine abuse by immunoanalysis and gas chromatography. | Drug abuse among college students is characterized by lower academic performance and long-term negative consequences. Screening to detect students at high risk of consuming drugs is of primary importance to insure early identification and appropriate levels of care. As a result, this study aimed to determine the curren... | 18,991,889 |
Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression. | Major depression and addiction are mental health problems associated with stressful events in life with high relapse and recurrence even after treatment. Many laboratories were not able to detect the presence of CB2 cannabinoid receptors (CB2-Rs) in healthy brains, but CB2-R expression has been demonstrated in rat micr... | 18,991,891 |
Asia's changing role in global climate change. | Asia's role in global climate change has evolved significantly from the time when the Kyoto Protocol was being negotiated. Emissions of carbon dioxide, the principal greenhouse gas, from energy use in Asian countries now exceed those from the European Union or North America. Three of the top five emitters-China, India,... | 18,991,898 |
Children's environmental health: intergenerational equity in action--a civil society perspective. | Since World War II, approximately 80,000 new commercial synthetic chemicals have been released into the environment, with approximately 1500 new chemicals released annually. Most of these have not been adequately tested for their impacts on human health or their particular impacts on children and the developing fetus. ... | 18,991,917 |
Domestic fuels, indoor air pollution, and children's health. | Reliance on solid biomass fuel for cooking and heating exposes many children of developing countries to high levels of indoor air pollution. This study investigates the association between household use of biomass fuels for cooking and prevalence of respiratory symptoms and diseases among children in rural India. The a... | 18,991,919 |
Zinc toxicity among galvanization workers in the iron and steel industry. | Galvanization is the process of coating steel or cast iron pieces with zinc, allowing complete protection against corrosion. The ultimate goal of this work was to assess the effect of occupational exposure to zinc in the galvanization process on different metals in the human body and to detect the association between z... | 18,991,923 |
Contents and occurrence of cadmium in the coals from Guizhou province, China. | Eleven raw coal samples were collected from Liuzhi, Suicheng, Zunyi, Xingren, Xingyi, and Anlong districts in Guizhou Province, Southwest China. The content of cadmium (Cd) in coal was determined using inductively coupled plasma mass-spectrometry (ICP-MS). Cd contents ranged from 0.146 to 2.74 ppm (whole coal basis), w... | 18,991,925 |
The studying of washing of arsenic and sulfur from coals having different ranges of arsenic contents. | To study the effectiveness of washing in removal of arsenic and sulfur from coals with different ranges of arsenic concentration, coal was divided into three groups on the basis of arsenic content: 0-5.5 mg/kg, 5.5 mg/kg-8.00 mg/kg, and over 8.00 mg/kg. The result shows that the arsenic in coals with higher arsenic con... | 18,991,931 |
Solid-waste management practices of households in Manila, Philippines. | The experiences and practices of household waste management of people in a barangay (village) in Manila, Philippines are documented. The data were gathered through an interview with household members using open-ended questions. Interviews were also conducted with garbage collectors as well as scavengers. Results showed... | 18,991,942 |
Protein kinases and addiction. | Although drugs of abuse have different chemical structures and interact with different protein targets, all appear to usurp common neuronal systems that regulate reward and motivation. Addiction is a complex disease that is thought to involve drug-induced changes in synaptic plasticity due to alterations in cell signal... | 18,991,950 |
Implication of activated astrocytes in the development of drug dependence: differences between methamphetamine and morphine. | Astrocytes are a subpopulation of glial cells that directly affect neuronal function. This review focuses on the potential functional roles of astrocytes in the development of behavioral sensitization and rewarding effects induced by chronic treatment with drugs of abuse. In vitro treatment of cortical neuron/glia cocu... | 18,991,953 |
ADHD and smoking: from genes to brain to behavior. | Attention-deficit/hyperactivity disorder (ADHD) and tobacco smoking are among the most common and costly psychiatric and behavioral problems. The rates of co-occurrence of these two common problems are larger than expected by chance. Despite progress in identifying the neural and genetic substrates of each, the mechani... | 18,991,955 |
Predicting treatment outcome in stimulant dependence. | The purpose of this review is to highlight some of the issues that need to be addressed to optimally use functional neuroimaging as a clinical tool to predict outcomes in substance use disorders. First, the importance of recognizing the clinical heterogeneity of the substance use disorders population is highlighted. We... | 18,991,963 |
Quality of life in young people with cystic fibrosis: effects of hospitalization, age and gender, and differences in parent/child perceptions. | The Cystic Fibrosis Questionnaire-Revised version (CFQ-R) was used to evaluate age/gender effects on quality of life (QOL) in Australian young people with cystic fibrosis (CF) who were inpatients/outpatients aged 6-18 years. Parent/child agreement was also examined. The CFQ-R was completed by 18 outpatients, and 15 inp... | 18,991,968 |
The interaction of sexually and naturally selected traits in the adaptive radiations of cichlid fishes. | The question of how genetic variation translates into organismal diversity has puzzled biologists for decades. Despite recent advances in evolutionary and developmental genetics, the mechanisms that underlie adaptation, diversification and evolutionary innovation remain largely unknown. The exceptionally diverse specie... | 18,992,003 |
Evaluation of reproductive functions in male adolescents following renal transplantation. | The aim of this study was to analyze the semen variables and hormone profiles in kidney transplanted male adolescents. Eight post-pubertal male patients who underwent successful renal tx during the peripubertal period and who had ESRD during childhood were enrolled in the study. Patients who underwent tx before 14 yr o... | 18,992,046 |
Neonates with severe infantile hepatic hemangioendothelioma: limitations of liver transplantation. | IHHE as the most common vascular tumor of the liver in infancy can present with acute postnatal liver and congestive heart failure. LTx may be a lifesaving option, but can be complicated by extrahepatic involvement and bleeding complications, especially in neonates. Here we discuss the benefit of LTx in cases of acute ... | 18,992,050 |
Calcineurin-inhibitor free immunosuppression with mycophenolate mofetil and corticosteroids in paediatric renal transplantation improves renal allograft function without increasing acute rejection. | The aim of this study was to determine whether CNIs can be safely withdrawn in paediatric patients with declining renal allograft function receiving MMF and corticosteroids for long-term immunosuppression following renal transplantation. We performed a retrospective review of paediatric renal transplant recipients who ... | 18,992,054 |
Separation of phasic arousal and expectancy effects in a speeded reaction time task via fMRI. | Sixteen neurologically normal volunteers performed a 2-choice speeded reaction time (RT) task in which the imperative was the change in color of a clock hand. During trial blocks with low temporal uncertainty (good clock condition), this imperative stimulus occurred at a fixed location (e.g., 2:00). In the bad clock co... | 18,992,072 |
Comparative study between slow freezing and vitrification of mouse embryos using different cryoprotectants. | The objective of this study was to evaluate the effects of different cryoprotectants and different cryopreservation protocols on the development of mouse eight-cell embryos. Mouse eight-cell embryos were cryopreserved by using propylene glycerol (PROH), ethylene glycerol (EG), dimethyl sulfoxide (DMSO) or glycerol (G) ... | 18,992,080 |
Single-layer centrifugation through colloid positively modifies the sperm subpopulation structure of frozen-thawed stallion spermatozoa. | The present study attempted to select the subpopulation of stallion spermatozoa that best survived a conventional freezing and thawing procedure, using centrifugation of post-thawed semen samples through a single layer of a glycidoxypropyltrimethoxysilane-coated silica colloid with a species-specific formulation (Andro... | 18,992,085 |
Expression of occludin in testis and epididymis of wild rabbits, Lepus sinensis coreanus. | Tight junctions (TJs) in inter-Sertoli junctional areas and epididymal epithelia build up the blood-testis barrier (BTB) and the blood-epididymal barrier (BEB), respectively. In this study, the expression of occludin, an integral member of the TJs, was examined in testis and different regions of epididymis of Lepus sin... | 18,992,101 |
Effects of hydrogen peroxide (H2O2) on fresh and cryopreserved buffalo sperm functions during incubation at 37 degrees C in vitro. | The magnitude of damage to buffalo spermatozoa during incubation with different levels of H2O2 was assessed. A total number of 24 ejaculates from four Murrah buffalo bulls were analysed in the study. Each ejaculate was split into two parts (part I and II). Part I was extended in Tris-egg yolk-citrate extender (20% egg ... | 18,992,123 |
Exploring valid reference genes for gene expression studies in Brachypodium distachyon by real-time PCR. | The wild grass species Brachypodium distachyon (Brachypodium hereafter) is emerging as a new model system for grass crop genomics research and biofuel grass biology. A draft nuclear genome sequence is expected to be publicly available in the near future; an explosion of gene expression studies will undoubtedly follow. ... | 18,992,143 |
Methylation of WTH3, a possible drug resistant gene, inhibits p53 regulated expression. | Previous results showed that over-expression of the WTH3 gene in MDR cells reduced MDR1 gene expression and converted their resistance to sensitivity to various anticancer drugs. In addition, the WTH3 gene promoter was hypermethylated in the MCF7/AdrR cell line and primary drug resistant breast cancer epithelial cells.... | 18,992,151 |
Isolated vertebral fractures give elevated serum protein S-100B levels. | Serum protein S-100B determinations have been widely proposed in the past as markers of traumatic brain injury and used as a predictor of injury severity and outcome. The purpose of this prospective observational case series was therefore to determine S-100B serum levels in patients with isolated injuries to the back. ... | 18,992,158 |
Cooperation between gatekeepers in sickness insurance - the perspective of social insurance officers. A qualitative study. | Objective was to describe variations in how social insurance officers conceive the cooperation with the health care in their daily work with sick leave. Fifteen social insurance officers (SIOs) working with administration of sickness benefits were interviewed. They were purposefully recruited to represent different par... | 18,992,160 |
Predictors of gastrointestinal lesions on endoscopy in iron deficiency anemia without gastrointestinal symptoms. | Iron deficiency anaemia (IDA) due to occult gastrointestinal (GI) blood loss usually remains unnoticed until patient become symptomatic. There is sparse data in IDA patients without gastrointestinal symptoms. This study was designed to find out the frequency and predictors of endoscopic lesions in IDA without gastroint... | 18,992,171 |
Between-year variation and spatial dynamics of Cryptosporidium spp. and Giardia spp. infections in naturally infected rodent populations. | Prevalence and abundance of Cryptosporidium spp. and Giardia spp. infections were studied over the 8-year period in 3 species of rodents in N.E. Poland (bank vole Myodes glareolus-1523; yellow-necked mouse Apodemus flavicollis- 638; common vole Microtus arvalis- 419). Prevalence was 53.8, 28.1 and 62.3% respectively fo... | 18,992,178 |
A population of serum deprivation-induced bone marrow stem cells (SD-BMSC) expresses marker typical for embryonic and neural stem cells. | The bone marrow represents an easy accessible source of adult stem cells suitable for various cell based therapies. Several studies in recent years suggested the existence of pluripotent stem cells within bone marrow stem cells (BMSC) expressing marker proteins of both embryonic and tissue committed stem cells. These s... | 18,992,240 |
Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation. | During the inflammatory response, activation of G-protein coupled receptors (GPCRs) by inflammatory mediators rapidly leads to inhibition of gap junction intercellular communication (GJIC); however, the steps that lead to this inhibition are not known. Combining high-resolution fluorescence microscopy and functional as... | 18,992,245 |
Automated 5-D analysis of cell migration and interaction in the thymic cortex from time-lapse sequences of 3-D multi-channel multi-photon images. | This paper presents automated methods to quantify dynamic phenomena such as cell-cell interactions and cell migration patterns from time-lapse series of multi-channel three-dimensional image stacks of living specimens. Various 5-dimensional (x, y, z, t, lambda) images containing dendritic cells (DC), and T-cells or thy... | 18,992,251 |
Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis. | Mycobacterium tuberculosis is able to establish a non-replicating state and survive in an intracellular habitat for years. Resuscitation of dormant M. tuberculosis bacteria is promoted by resuscitation-promoting factors (Rpfs), which are secreted from slowly replicating bacteria close to dormant bacteria. Here we repor... | 18,992,255 |
Crystallographic analysis of a sex-specific enhancer element: sequence-dependent DNA structure, hydration, and dynamics. | The crystal structure of a sex-specific enhancer element is described at a resolution of 1.6 A. This 16-bp site, designated Dsx(A), functions in the regulation of a genetic switch between male and female patterns of gene expression in Drosophila melanogaster. Related sites are broadly conserved in metazoans, including ... | 18,992,257 |
Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. | Variation in genes associated with serum levels of proteins may be useful for examining specific disease pathways. Using data from a large study of colon cancer, we examine genetic variants in insulin, inflammation, estrogen, metabolizing enzymes, and energy homeostasis genes to explore associations with microsatellite... | 18,992,263 |
Development of an asymmetric PCR-ELISA typing method for citrus tristeza virus based on the coat protein gene. | The coat protein gene of isolates of citrus tristeza virus (CTV) from 20 citrus-producing regions around the world was amplified by RT-PCR, TA cloned, and characterized by SSCP. Haplotypes that produced different patterns within each geographic region were sequenced and a database of 153 accessions of CTV was assembled... | 18,992,281 |
Stimulus intensity dependence of cerebral blood volume changes in left frontal lobe by low-frequency rTMS to right frontal lobe: A near-infrared spectroscopy study. | Repetitive transcranial magnetic stimulation (rTMS) has recently been widely employed for the investigation of brain function and treatment of psychiatric and neurological disorders. Although high and low stimulation frequencies are assumed to activate and deactivate brain function, respectively, the optimal parameters... | 18,992,287 |
Lipid compounds of the umbilical cord vein and their alterations in preeclampsia. | The lipid composition of vascular walls changes during development, ageing and pathological processes. Preeclampsia is the most common pregnancy-associated pathological syndrome. It is accompanied by significant remodelling of the extracellular matrix, both in the umbilical cord vessels and in the surrounding Wharton's... | 18,992,302 |
In vitro and in vivo characteristics of prochlorperazine oral disintegrating film. | Oral disintegrating film containing prochlorperazine, a dopamine D(2) receptor antagonist with anti-emetic property, was newly developed using microcrystalline cellulose, polyethlene glycol and hydroxypropylmethyl cellulose as the base materials. The uniformity of dosage units of the preparation was acceptable accordin... | 18,992,311 |
Imaging neurodegeneration in Parkinson's disease. | Neuroimaging techniques have evolved over the past several years giving us unprecedented information about the degenerative process in Parkinson's disease (PD) and other movement disorders. Functional imaging approaches such as positron emission tomography (PET) and single photon emission computerised tomography (SPECT... | 18,992,326 |
Alternative splicing and disease. | Almost all protein-coding genes are spliced and their majority is alternatively spliced. Alternative splicing is a key element in eukaryotic gene expression that increases the coding capacity of the human genome and an increasing number of examples illustrates that the selection of wrong splice sites causes human disea... | 18,992,329 |
Sexual and seasonal plasticity in the emission of social electric signals. Behavioral approach and neural bases. | Behavior in electric fish includes modulations of a stereotyped electric organ discharge (EOD) in addition to locomotor displays. Gymnotiformes can modulate the EOD rate to produce signals that participate in different behaviors. We studied the reproductive behavior of Brachyhypopomus pinnicaudatus both in the wild and... | 18,992,332 |
Altered pharmacology and GABA-A receptor subunit expression in dorsal midline thalamic neurons in limbic epilepsy. | The mediodorsal (MD) and paraventricular (PV) thalamic nuclei play a significant role in limbic epilepsy, and previous reports have shown changes in GABA-A receptor (GABAAR) mediated synaptic function. In this study, we examined changes in the pharmacology of GABAergic drugs and the expression of the GABAAR subunits in... | 18,992,345 |
Cytolocalization of the class V chitin synthase in the yeast, hyphal and sclerotic morphotypes of Wangiella (Exophiala) dermatitidis. | Wangiella (Exophiala) dermatitidis is a polymorphic fungus that produces polarized yeast and hyphae, as well as a number of non-polarized sclerotic morphotypes. The phenotypic malleability of this agent of human phaeohyphomycosis allows detailed study of its biology, virulence and the regulatory mechanisms responsible ... | 18,992,354 |
Pre-B cell colony-enhancing factor in lower vertebrates: first evidence of this cytokine being involved in antioxidant activity by reconstruction of a novel NAD salvage pathway in E. coli. | The pre-B cell colony-enhancing factor identified in mammals is an important cytokine involved in multiple functions, such as immunoregulation, cellular proliferation and differentiation. However, little is known about its existence and function in lower vertebrates; therefore, we investigated the characterization, exp... | 18,992,361 |
Deletion 2p25.2: a cryptic chromosome abnormality in a patient with autism and mental retardation detected using aCGH. | We describe a 7-year-old patient with autism, moderate mental retardation, secondary microcephaly, agenesis of right optic nerve, and dysmorphic features carrying a de novo cryptic deletion of chromosome 2p25.2, detected by aCGH. Pure monosomies of 2p are very rare, and are usually observed as part of more complex aber... | 18,992,374 |
Funding of drugs: do vaccines warrant a different approach? | Vaccines have features that require special consideration when assessing their cost-effectiveness. These features are related to herd immunity, quality-of-life losses in young children, parental care and work loss, time preference, uncertainty, eradication, macroeconomics, and tiered pricing. Advisory committees on pub... | 18,992,409 |
Carotid artery entrapment by the hyoid bone. | We report a patient with a transient ischemic attack presumably caused by an entrapment of the internal carotid artery by the hyoid bone and without a significant carotid artery stenosis. The patient was operated on, with a release of the right internal and external carotid artery and resection of the right greater cor... | 18,992,420 |
Surgical management of renal tumors: a historical perspective. | The modern era of renal surgery began on August 2, 1869 when the first planned nephrectomy on a living human being was performed. Eighteen years later in 1887, the first partial nephrectomy to remove a renal tumor was performed. Both total and partial nephrectomy have become the hallmark surgical procedures used today ... | 18,992,608 |
Predictors of smoking relapse in women with cardiovascular disease in a 30-month study: extended analysis. | To identify predictors of long-term cessation after intervention for woman hospitalized with cardiovascular diseases (CVD). A randomized clinical trial (RCT) with a 30-month follow-up was conducted, recruiting 277 woman smokers with CVD from 10 hospitals. The intervention consisted of inpatient and outpatient counselin... | 18,992,629 |
Embryonal rhabdomyosarcoma with a novel t(2;6)(p23;p21.1). | Chromosomal translocations are infrequently encountered in embryonal rhabdomyosarcoma (E-RMS). Here, we present a case of an infant with a chest wall E-RMS in which t(2;6)(p23;p21.1) was detected. Despite the involvement of the 2p23 locus in the translocation, the tumor did not express ALK. The t(2;6)(p23;p21.1) is a n... | 18,992,640 |
MLL rearrangement with t(6;11)(q15;q23) as a sole abnormality in a patient with de novo acute myeloid leukemia: conventional cytogenetics, FISH, and multicolor FISH analyses for detection of rare MLL-related chromosome abnormalities. | We report a rare case of acute myeloid leukemia (AML) with t(6;11)(q15;q23) in a 50-year-old female showing a poor prognosis. Bone marrow biopsy revealed markedly hypercellular marrow with infiltrates of myeloblasts, consistent with AML-M2 morphology. The karyotype of this patient was 46,XX,t(6;11)(q15;q23) in all anal... | 18,992,643 |
Soluble and membranous vascular endothelial growth factor receptor-1 in pregnancies complicated by pre-eclampsia. | Vascular endothelial growth factor receptor-1 (VEGFR-1) is essential for the normal development and function of the placenta. Defective placental vasculogenesis and trophoblast function may lead to pre-eclampsia, a pregnancy-specific syndrome of hypertension and proteinuria. In order to study the association of VEGFR-1... | 18,992,679 |
An historical perspective of early Italian air medical transport. | The early times of aviation medicine were dominated by military actions and needs. This article describes the pioneering era of Italian air medical transport during the period between World War I and early World War II. | 18,992,688 |
Quality improvement in long term care: the psychotropic assessment tool (PAT). | There are already a substantial number of individuals with dementia in long-term care. Many nursing home patients have difficult behaviors and are currently managed with psychotropic medications. Medications for behavior need to be titrated and monitored over time for efficacy and safety, and subsequently tapered if in... | 18,992,701 |
Ischemic tolerance following low dose NMDA involves modulation of cellular stress proteins. | Mild NMDA receptor activation is correlated with neuroprotection in models of cerebral ischemia. Neuroprotection with NMDA manifests as a form of ischemic tolerance and involves the induction of cellular stress systems sensitive to disturbances in cellular calcium homeostasis. Unilateral micro-injection of 10, 160 and ... | 18,992,720 |
Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. | PlexinD1 is a membrane-bound receptor that mediates signals derived from class 3 secreted semaphorins. Although semaphorin signaling in axon guidance in the nervous system has been extensively studied, functions outside the nervous system including important roles in vascular patterning have also been demonstrated. Ina... | 18,992,737 |
Role for protein geranylgeranylation in adult T-cell leukemia cell survival. | Adult T-cell leukemia (ATL) is a fatal lymphoproliferative disease that develops in human T-cell leukemia virus type I (HTLV-I)-infected individuals. Despite the accumulating knowledge of the molecular biology of HTLV-I-infected cells, effective therapeutic strategies remain to be established. Recent reports showed tha... | 18,992,741 |
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. | IL-17-producing CD4(+) T-helper cells (Th17) contribute to chronic autoimmune inflammation in the brain, and levels of Th17-derived cytokines increase in patients with colitis, suggesting a role in pathogenesis. We analyzed the roles of Th17 cells and the transcription factor retinoic acid receptor-related organ recept... | 18,992,745 |
Androgens and bone. | Testosterone is the major gonadal sex steroid produced by the testes in men. Testosterone is also produced in smaller amounts by the ovaries in women. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione. These androgens collectively affect skeletal... | 18,992,761 |
Corticotropin releasing factor influences aggression and monoamines: modulation of attacks and retreats. | Salmonids establish social hierarchies as a result of aggressive social interactions. The establishment of dominant or subordinate status is strongly linked to neuroendocrine responses mediated through the stress axis. In this study, we tested the effects of introcerebroventricular (icv) corticotropin releasing factor ... | 18,992,791 |
Involvement of cytochrome P450-mediated metabolism in tienilic acid hepatotoxicity in rats. | Tienilic acid is reported to be converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro. In vivo, however, the metabolites have not been detected and their effect on liver function is unknown. We previously demonstrated that tienilic acid decreased the GSH level and upregulated genes responsive to ox... | 18,992,796 |
Engineering natural products using combinatorial biosynthesis and biocatalysis. | Many biologically active natural products are produced by the host organisms using dedicated biosynthetic pathways. The programming rules of these pathways may be rationally manipulated through combinatorial biosynthesis to produce natural products that contain structural variations or enhanced pharmacological properti... | 18,992,814 |
CR3 complement receptor: cloning and characterization in rainbow trout. | The beta 2 integrin CR3 is a leukocyte adhesion heterodimeric glycoprotein which functions both as receptor for iC3b and in several cell-cell and cell-substrate adhesion interactions. In order to elucidate the molecular evolution of the CR3 receptor, here we report the cloning and characterization of its beta2 (CD18) a... | 18,992,821 |
Plant antigens cross-react with rat polyclonal antibodies against KLH-conjugated peptides. | Keyhole limpet hemocyanin (KLH)-conjugated peptides are routinely used to raise polyclonal antibodies for biochemical or immunolocalization studies. Rats are suitable for producing antisera against plant antigens as they often lack non-specific response towards plant materials. We attempted to obtain rat antisera again... | 18,992,832 |
Effect of hypoxic treatment on bone marrow cells that are able to migrate to the injured liver. | Restricted numbers and poor regenerative properties limit the use of adult stem cells. We tested the effect of hypoxic treatment as a method by which to increase cell migration. Bone marrow cells (BMCs) were cultured under oxygen saturations of 0.1, 3, and 20% for 24h. After hypoxic treatment, BMCs of apoptotic fractio... | 18,992,833 |
Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis. | Osteoporosis, a highly heritable disease, is characterized mainly by low bone-mineral density (BMD), poor bone geometry, and/or osteoporotic fractures (OF). Copy-number variation (CNV) has been shown to be associated with complex human diseases. The contribution of CNV to osteoporosis has not been determined yet. We co... | 18,992,858 |
Development and validation of a solid-phase extraction and gas chromatography-tandem mass spectrometry method for the determination of isopropyl-9H-thioxanthen-9-one in carton packaged milk. | A simple and efficient method for the determination of isopropyl-9H-thioxanten-9-one (ITX) in different fat content milk samples and baby milk samples stored in packaged cartons was developed and validated. Samples were extracted using solid-phase extraction (SPE) and analysed by gas chromatography-tandem mass spectrom... | 18,992,884 |
Improved conjugation and purification strategies for the preparation of protein-polysaccharide conjugates. | A glycoconjugate constituted by the Streptococcus pneumoniae serotype 14 capsular polysaccharide (CPS14) and bovine serum albumin (BSA) was prepared, and the unique properties of Sephadex LH-20 were used to separate the conjugate from the unconjugated material. The strength of this approach consists in its capacity to ... | 18,992,885 |
Phase inversion of the Pickering emulsions stabilized by plate-shaped clay particles. | We investigated the phase inversion of Pickering emulsions stabilized by plate-shaped clay particles. Addition of water induced a phase inversion from a water-in-oil (W/O) emulsion to an oil-in-water (O/W) emulsion when the amount of the oil phase exceeded a limiting amount of oil absorption to solid particles. On the ... | 18,992,900 |
Ependymoma of the sella turcica: a variant of pituicytoma. | A broad spectrum of neoplasms affects the sellar region. Among these, gliomas are rare, most being tumors of pituicytes such as granular cell tumor and pituicytoma. Only 4 ependymomas of the human sellar region have been reported to date and all have had classic histologic features. Herein, we describe the clinicopatho... | 18,992,914 |
Removal mechanisms for endocrine disrupting compounds (EDCs) in wastewater treatment - physical means, biodegradation, and chemical advanced oxidation: a review. | Endocrine disrupting compounds (EDCs) are pollutants with estrogenic or androgenic activity at very low concentrations and are emerging as a major concern for water quality. Within the past few decades, more and more target chemicals were monitored as the source of estrogenic or androgenic activity in wastewater, and g... | 18,992,918 |
The dynamics of protein and metal metabolism in acclimated and Cd-exposed freshwater crabs (Potamonautes warreni). | Climatic and man-made impacts induced dynamic molecular responses in the South African freshwater crab, Potamonautes warreni. Adult crabs exhibited MT-like protein, binding Cd (0.02micromolg(-1) wet mass+/-0.02), Cu (0.326micromolg(-1) wet mass+/-0.15), and Zn (0.534micromolg(-1) wet mass+/-0.20). The native protein bi... | 18,992,941 |
Tributyltin-binding protein type 1 has a distinctive lipocalin-like structure and is involved in the excretion of tributyltin in Japanese flounder, Paralichthys olivaceus. | Tributyltin-binding protein type 1 (TBT-bp1) is a newly discovered protein that binds with TBT in the blood of the Japanese flounder, Paralichthys olivaceus. We determined the genomic sequence of TBT-bp1 and found that this protein has a conserved exon-intron structure that is common to the lipocalin protein family. Th... | 18,992,946 |
Autophagy and aging: keeping that old broom working. | Autophagy, a highly conserved mechanism of quality control inside cells, is essential for the maintenance of cellular homeostasis and for the orchestration of an efficient cellular response to stress. The decrease in autophagic activity observed in almost all cells and tissues as organisms age was proposed to contribut... | 18,992,957 |
Allergic patch test reactions associated with cosmetics: retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2004. | Allergy to cosmetics is common. We sought to characterize patients with positive patch test reactions associated with a cosmetic source, to identify common allergens; and to explore gender and occupational associations. We performed a retrospective, cross-sectional analysis. Of 6621 female and 3440 male patients, 1582 ... | 18,992,965 |
Avoidance response of Enchytraeus albidus in relation to carbendazim ageing. | In this study, avoidance response of Enchytraeus albidus to LUFA 2.2 soil contaminated with pesticide carbendazim was investigated. The aim was to clarify minimal test duration and temporal changes in avoidance response due to contamination ageing. Firstly, the concentration causing 50% avoidance (EC(50)) was determine... | 18,992,976 |
Reliability of pulse palpation by healthcare personnel to diagnose paediatric cardiac arrest. | To determine the reliability of pulse palpation to diagnose paediatric cardiac arrest. With all cardiovascular information obscured, 209 doctors and nurses (rescuers) were requested once each to determine if a pulse was present in 1 of 16 infants and children (average age 1.8 years, range 1 week-13 years) provided with... | 18,992,985 |
Arsenic, lead and nickel accumulation in Rubus ulmifolius growing in contaminated soil in Portugal. | This work investigates the potential of Rubus ulmifolius, indigenous to a metal contaminated site--Esteiro de Estarreja--for phytoremediation purposes. The site has a long history of metal contamination. The accumulation of lead (Pb), arsenic (As) and nickel (Ni) in different sections--roots, stems and leaves - of the ... | 18,992,988 |
[Lepromatous leprosy revealed by a swollen hands syndrome]. | Osteoarticular pathology in leprosy is common and described at all stages, but rarely as the most evident clinical manifestation. We report a case of borderline lepromatous leprosy with initial and disabling hands edema. The swollen hands syndrome is probably due to chronic Mycobacterium leprae tenosynovitis. | 18,993,001 |
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