title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Glycerol monooleate-blood interactions. | In the present study the initial blood compatibility of glycerol monooleate (GMO)-coated surfaces was evaluated after deposition to surfaces and in bulk. The model surface was silica onto which multiple layers of fibrinogen or human serum albumin (HSA) was immobilized. The protein-coated surfaces were subsequently dip-... | 18,996,684 |
Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors. | Compounds with homopiperazine skeleton are designed to find a potent DPP-IV inhibitor without inhibiting CYP. Thus a series of beta-aminoacyl-containing homopiperazine derivatives was synthesized and evaluated. Compounds with acid moiety were found to be potent inhibitors of DPP-IV without inhibiting CYP 3A4. More spec... | 18,996,694 |
New jasmonate analogues as potential anti-inflammatory agents. | In an effort to develop new anti-inflammatory agents, methyl jasmonate analogues (2-20) were synthesized and evaluated for their inhibitory effects on the production of pro-inflammatory mediators (NO, IL-6, and TNF-alpha) in lipopolysaccharide (LPS)-activated RAW264.7 murine macrophage cells. The introduction of an eno... | 18,996,699 |
Confocal fluorescence polarization microscopy for linear unmixing of spectrally similar labels. | Studies of biological samples often call for simultaneous identification of multiple molecular or structural components. Multiple labelling fluorescence techniques are a powerful way of achieving this. However, the ability to distinguish a number of fluorescent probes unambiguously can be restricted by the fact that fl... | 18,996,704 |
Motor unit tracking with high-density surface EMG. | Following (tracking) individual motor units over time can provide important new insights, both into the relationships among various motor unit (MU) morphological and functional properties and into how these properties are influenced by neuromuscular disorders or interventions. The present study aimed to determine wheth... | 18,996,724 |
Interpretation of chemically created periapical lesions using 2 different dental cone-beam computerized tomography units, an intraoral digital sensor, and conventional film. | To assess the diagnostic potential of 2 different cone-beam computerized tomography (CT) units and compare this with intraoral digital and conventional film in the detection of chemically created periapical lesions. Periapical lesions were created chemically in 27 intact roots of 23 teeth (6 incisors, 4 canines, 6 prem... | 18,996,725 |
Direct measurement of human movement by accelerometry. | Human movement has been the subject of investigation since the fifth century when early scientists and researchers attempted to model the human musculoskeletal system. The anatomical complexities of the human body have made it a constant source of research to this day with many anatomical, physiological, mechanical, en... | 18,996,729 |
Laparoscopic fundoplication compared with laparoscopic gastric bypass in morbidly obese patients with gastroesophageal reflux disease. | Gastroesophageal reflux disease (GERD) is commonly associated with morbid obesity. Laparoscopic fundoplication is a standard surgical treatment for GERD, and laparoscopic gastric bypass has been shown to effectively resolve GERD symptoms in the morbidly obese. We sought to compare the in-hospital outcomes of morbidly o... | 18,996,768 |
Synchronous thymoma and thymic carcinoid in a woman with multiple endocrine neoplasia type 1: case report and review. | To report a rare case of multiple endocrine neoplasia type 1 (MEN 1) in conjunction with concomitant thymoma and thymic carcinoid. We describe a never before reported case involving a 63-year-old female patient with MEN 1 who had synchronous thymoma and thymic carcinoid tumors. A review of the pertinent literature is a... | 18,996,790 |
Weight loss improves the response of obese patients with moderate-to-severe chronic plaque psoriasis to low-dose cyclosporine therapy: a randomized, controlled, investigator-blinded clinical trial. | Chronic plaque psoriasis is frequently associated with obesity. The effect of a hypoenergetic diet on psoriasis has not been investigated. The objective was to investigate whether moderate weight loss (ie, 5-10% of body weight) increases the therapeutic response to a low dose of cyclosporine in obese patients with mode... | 18,996,858 |
Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels. | Despite the recognition that central obesity plays a critical role in chronic disease, few large-scale imaging studies have documented human variation in abdominal adipose tissue patterning. We aimed to compare the associations between abdominal subcutaneous adipose tissue (ASAT) and visceral abdominal tissue (VAT), wh... | 18,996,861 |
A 22-y prospective study of fish intake in relation to prostate cancer incidence and mortality. | Fish and seafood n-3 fatty acids may prevent or delay the progression of prostate cancer, but epidemiologic studies do not uniformly support this hypothesis. We examined the relation of fish and seafood n-3 fatty acid intakes with prostate cancer incidence and mortality. We conducted a prospective cohort study among 20... | 18,996,866 |
Association of breakfast energy density with diet quality and body mass index in American adults: National Health and Nutrition Examination Surveys, 1999-2004. | Recent reports suggest that dietary energy density (ED) is associated with diet quality, energy intake, and body weight. Breakfast consumption was also associated with diet quality and body weight; however, little is known about the association of breakfast consumption with dietary ED. We examined differences in the ED... | 18,996,877 |
The UCSC Genome Browser Database: update 2009. | The UCSC Genome Browser Database (GBD, http://genome.ucsc.edu) is a publicly available collection of genome assembly sequence data and integrated annotations for a large number of organisms, including extensive comparative-genomic resources. In the past year, 13 new genome assemblies have been added, including two impo... | 18,996,895 |
Mumijo traditional medicine: fossil deposits from antarctica (chemical composition and beneficial bioactivity). | Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well. In the present stud... | 18,996,940 |
Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats. | Berberine (BBR), a hypoglycemic agent, has shown beneficial metabolic effects for anti-diabetes, but its precise mechanism was unclear. Glucagon-like peptide-1 (GLP-1) is considered to be an important incretin that can decrease hyperglycemia in the gastrointestinal tract after meals. The aim of this study was to invest... | 18,996,945 |
Hypotonic resistance of boar spermatozoa: sperm subpopulations and relationship with epididymal maturation and fertility. | Hypotonic resistance of boar spermatozoa was investigated by measuring the ratio of live/dead spermatozoa (SYBR-14/propidium iodide) by flow cytometry after hypotonic stress. The survival rate of ejaculated spermatozoa incubated in hypotonic solutions ranging from 3 to 330 mmol/kg followed a sigmoid curve that fitted a... | 18,996,973 |
Impact of perception of socioeconomic burden on advocacy for patient autonomy in end-of-life decision making: a study of societal attitudes. | We investigated the impact of perception of socioeconomic burden on beliefs regarding a patient's autonomy in end-of-life (EOL) decision making. We also sought to identify the characteristics of individuals who advocate patient autonomy and their attitudes toward other EOL issues. A total of 1055 individuals from the K... | 18,996,980 |
Abundance and activity of methanotrophic bacteria in littoral and profundal sediments of lake constance (Germany). | The abundances and activities of aerobic methane-oxidizing bacteria (MOB) were compared in depth profiles of littoral and profundal sediments of Lake Constance, Germany. Abundances were determined by quantitative PCR (qPCR) targeting the pmoA gene and by fluorescence in situ hybridization (FISH), and data were compared... | 18,997,033 |
Consequences of selection for improving production traits on the frequency of deleterious alleles for fitness. | In this study the effect of artificial selection on BLUP EBV for production traits on the allele frequencies of a pleiotropic QTL affecting both production and disease susceptibility was investigated. Stochastic simulations were used to model artificial selection on a production trait that is controlled, in part, by a ... | 18,997,080 |
Neuroprotective effect of an antioxidant, lutein, during retinal inflammation. | Lutein has been the focus of recent study as a possible therapeutic approach for retinal diseases, but the molecular mechanism of its neuroprotective effect remains to be elucidated. The aim of this study was to investigate, with the use of a mouse endotoxin-induced uveitis (EIU) model, the neuroprotective effects of l... | 18,997,089 |
Alteration in iron metabolism during retinal degeneration in rd10 mouse. | Altered iron metabolism was implicated in retinal and macular degeneration. This study was designed to further elucidate iron homeostasis during the course of retinal degeneration in mice. Retinal mRNA and protein expression of transferrin, transferrin receptor, and ceruloplasmin were evaluated during retinal degenerat... | 18,997,094 |
Time and dose dependence of pluronic bioactivity in hyperthermia-induced tumor cell death. | Pluronic block copolymers have been shown to sensitize cancer cells resulting in an increased activity of antineoplastic agents. In the current study we examined a new application of Pluronic bioactivity in potentiating hyperthermia-induced cancer cell injury. DHD/K12/TRb rat adenocarcinoma cells were exposed to low-gr... | 18,997,100 |
A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response. | Structural similarities between apolipoprotein(a) (apo(a)), the unique apoprotein of lipoprotein(a), and plasminogen, the zymogen of plasmin, can interfere with functions of plasmin (ogen) in vitro. The purpose of this study was to evaluate the role of apo(a) in inflammation in vivo using apo(a) transgenic mice and to ... | 18,997,104 |
miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. | Neurogenesis during the development of the mammalian cerebral cortex involves a switch of neural stem and progenitor cells from proliferation to differentiation. To explore the possible role of microRNAs (miRNAs) in this process, we conditionally ablated Dicer in the developing mouse neocortex using Emx1-Cre, which is ... | 18,997,113 |
The cytoplasm of mouse germinal vesicle stage oocytes can enhance somatic cell nuclear reprogramming. | In mammalian cloning, evidence suggests that genomic reprogramming factors are located in the nucleus rather than the cytoplasm of oocytes or zygotes. However, little is known about the mechanisms of reprogramming, and new methods using nuclear factors have not succeeded in producing cloned mice from differentiated som... | 18,997,114 |
Propagating waves of activity in the neocortex: what they are, what they do. | The development of voltage-sensitive dyes (VSD) and fast optical imaging techniques have brought us a new tool for examining spatiotemporal patterns of population neuronal activity in the neocortex. Propagating waves have been observed during almost every type of cortical processing examined by VSD imaging or electrode... | 18,997,124 |
Presurgical systemic treatment of nonmetastatic breast cancer: facts and open questions. | There are several advantages of administering primary systemic therapy (PST) instead of adjuvant therapy in the management of early breast cancer patients: (a) PST allows for a quantifiable evaluation of the sensitivity or resistance of any treated case and (b) the response assessment offers the opportunity to "cross o... | 18,997,125 |
Significant publications on infectious diseases pharmacotherapy in 2007. | Significant publications on infectious diseases (ID) pharmacotherapy in 2007 were compiled and summarized. On January 2, 2008, the 21 members of the Houston Infectious Disease Network (HIDN) were asked to select an article that was published in a peer-reviewed journal between January 1 and December 31, 2007, and write ... | 18,997,127 |
Compatibility of risedronate sodium tablets with food thickeners. | The chemical compatibility of commercially available food thickeners used with risedronate sodium tablets is examined. Plastic 250-mL disposable beakers were used to prepare solutions for compatibility testing. Two ounces of purified water at room temperature was added to each beaker. One risedronate sodium 35-mg table... | 18,997,142 |
Endothelin-converting enzyme-1 increases in atherosclerotic mice: potential role of oxidized low density lipoproteins. | The aim of our study was to analyze the relationships between atherosclerosis and endothelin-converting enzyme-1 (ECE-1). Four-week-old C57BL/6J [wild-type (WT)] and apolipoprotein E-deficient (apoE) mice were fed with a standard or Western-type fat diet for 8 wks. ApoE showed atherosclerotic lesions in the aorta, high... | 18,997,155 |
Higher daily peritoneal protein clearance when initiating peritoneal dialysis is independently associated with peripheral arterial disease (PAD): a possible new marker of systemic endothelial dysfunction? | Patients starting peritoneal dialysis (PD) with active cardiovascular disease (CVD) show higher protein and albumin levels in peritoneal effluent. Peripheral arterial disease (PAD) is increasingly recognized as an entity particularly associated with higher mortality. To explore whether higher daily peritoneal protein c... | 18,997,161 |
HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism. | The finding that the risk of relapse in hematologic malignancy decreases after allogeneic hematopoietic stem cell transplantation (HSCT) has lead to the concept of a graft-versus-leukemia (GVL) effect. However, this beneficial effect is considered to be frequently offset by graft-versus-host disease (GVHD). Thus, impro... | 18,997,170 |
Left ventricular volume measurement with echocardiography: a comparison of left ventricular opacification, three-dimensional echocardiography, or both with magnetic resonance imaging. | Both contrast enhanced (CE) two-dimensional echocardiography (2DE) and three-dimensional echocardiography (3DE) have been proposed as techniques to improve the accuracy of left ventricular (LV) volume measurements. We sought to examine the accuracy of non-contrast (NC) and CE-2DE and 3DE for calculation of LV volumes a... | 18,997,179 |
Oral fluoropyrimidines (capecitabine or S-1) and cisplatin as first line treatment in elderly patients with advanced gastric cancer: a retrospective study. | This study aimed to evaluate the safety and efficacy of oral fluoropyrimidines and cisplatin therapy in elderly patients with untreated advanced gastric cancer (AGC) retrospectively. In addition, we evaluated the relative activity and toxicity of these agents in this patient population. Clinical data from 72 patients w... | 18,997,184 |
Use of domestic detergents in the California mastitis test for high somatic cell counts in milk. | The California mastitis test (CMT) is used on farms to identify subclinical mastitis by an indirect estimation of the somatic cell count (SCC) in milk. Four commercially available detergents were compared with a bespoke cmt fluid for their ability to detect milk samples with a scc above 200,000 cells/ml; differences be... | 18,997,186 |
Price transparency for medical devices. | Hospital buyers of medical devices contract with manufacturers with market power that sell differentiated products. The medical staff strongly influences hospitals' choice of devices. Sellers have sought to limit disclosure of transaction prices. Policy-makers have proposed legislation mandating disclosure, in the inte... | 18,997,210 |
Probable role of immunological tolerance to ischemia injury in brain. | To address the issues of immunological tolerance to ischemia injury in the brain we have researched ischemic stroke patients with and without prodromal transitional ischemic attacks (TIAs) for several blood acute phase reactants involved in inflammatory reactions in respect to initial infarct size, clinical course of d... | 18,997,250 |
[Prevention of thrombolitic compications with atrial fibrillation]. | This study presents the modern principles of prevention and treatment of thrombolitic complications in patients with atrial fibrillation. The adequate tactics and algorithm of antithrombotic therapy in the case of variety versions of this disease is considered in this study. It described the efficiency and safety of or... | 18,997,251 |
[Dynamics of epizootic activity of natural foci of plague in Georgia]. | Based on long term (1960-1990) surveillance data analysis of the plague natural foci activity on the territory of Georgia hypothetical parameters of epizootic activity algorithm have been revealed and potential role for susceptibility of noncultivated forms in the ecology of plague has been suggested. The article empha... | 18,997,254 |
Scatter kernel estimation with an edge-spread function method for cone-beam computed tomography imaging. | The clinical applications of kilovoltage x-ray cone-beam computed tomography (CBCT) have been compromised by the limited quality of CBCT images, which typically is due to a substantial scatter component in the projection data. In this paper, we describe an experimental method of deriving the scatter kernel of a CBCT im... | 18,997,269 |
Hydrophobic duck feathers and their simulation on textile substrates for water repellent treatment. | Inspired by the non-wetting phenomena of duck feathers, the water repellent property of duck feathers was studied at the nanoscale. The microstructures of the duck feather were investigated by a scanning electron microscope (SEM) imaging method through a step-by-step magnifying procedure. The SEM results show that duck... | 18,997,276 |
Amadori-glycated albumin-induced vascular smooth muscle cell proliferation and expression of inhibitor of apoptosis protein-1 and nerve growth factor-gamma. | We investigated the effects of Amadori-glycated serum albumin (GSA) on cell proliferation as well as expressions of antioxidant enzyme genes and marker genes associated with signal transduction pathways in rat aortic vascular smooth muscle cells (VSMCs). Quiescent VSMCs treated with GSA (0-500 microg/mL, 48 h) exhibite... | 18,997,277 |
Administration and scoring variance on the ADAS-Cog. | The Alzheimer's Disease Assessment Scale - Cognitive (ADAS-Cog) is the most commonly used primary outcome instrument in clinical trials for treatments of dementia. Variations in forms, administration procedures and scoring rules, along with rater turnover and intra-rater drift may decrease the reliability of the instru... | 18,997,299 |
Plasticity and restoration of vision after visual system damage: an update. | The traditional view that visual system damage is permanent has given way to a more optimistic view. Visual loss does not remain unchanged but it can recover spontaneously to some extent. Even when the period of spontaneous recovery has ended there is still additional potential for plasticity and regeneration, even mon... | 18,997,303 |
A special role for binocular visual input during development and as a component of occlusion therapy for treatment of amblyopia. | To review work on animal models of deprivation amblyopia that points to a special role for binocular visual input in the development of spatial vision and as a component of occlusion (patching) therapy for amblyopia. The studies reviewed employ behavioural methods to measure the effects of various early experiential ma... | 18,997,317 |
Video games as a tool to train visual skills. | Adult brain plasticity, although possible, is often difficult to elicit. Training regimens in adults can produce specific improvements on the trained task without leading to general enhancements that would improve quality of life. This paper considers the case of playing action video games as a way to induce widespread... | 18,997,318 |
Crystallization and preliminary crystallographic analysis of exo-alpha-1,5-L-arabinofuranosidase from Streptomyces avermitilis NBRC14893. | Exo-alpha-1,5-L-arabinofuranosidase from Streptomyces avermitilis NBRC14893 (SaAraf43A) is composed of a single-chain peptide containing a catalytic domain belonging to glycosyl hydrolase family 43 and a substrate-binding domain belonging to carbohydrate-binding module family 42. The enzyme catalyzes the hydrolysis of ... | 18,997,327 |
Crystallization and preliminary X-ray analysis of the human respiratory syncytial virus nucleocapsid protein. | Human respiratory syncytial virus (HRSV) has a nonsegmented negative-stranded RNA genome which is encapsidated by the HRSV nucleocapsid protein (HRSVN) that is essential for viral replication. HRSV is a common cause of respiratory infection in infants, yet no effective antiviral drugs to combat it are available. Recent... | 18,997,331 |
Crystallization and preliminary X-ray diffraction studies of the BTL2 lipase from the extremophilic microorganism Bacillus thermocatenulatus. | Bacillus thermocatenulatus lipase 2 (BTL2) is a thermoalkalophilic lipase that has been reported as an enantioselective biocatalyst for diverse reactions and that heads a group of enzymes that share high resistance towards many inactivation agents (heat, organic solvents, pH etc.). This makes BTL2 an important research... | 18,997,337 |
Crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 6. | Adeno-associated viruses are being developed as vectors for gene therapy and have been used in a number of clinical trials. Vectors to date have been based on the type species AAV-2, the structure of which was published in 2002. There is growing interest in modulating the cellular tropism and immune neutralization of A... | 18,997,346 |
Purification, crystallization and preliminary crystallographic study of the putative enolase MJ0232 from the hyperthermophilic archaeon Methanococcus jannaschii. | Enolase is a glycolytic enzyme that catalyzes the interconversion of phosphoenolpyruvate and 2-phosphoglycerate. In order to gain insight into the biological significance of the oligomeric state of this enzyme, the putative enolase MJ0232 from the hyperthermophilic archaeon Methanococcus jannaschii was cloned, overexpr... | 18,997,349 |
Antimalarial compounds from the root bark of Garcinia polyantha Olv. | Eight compounds were isolated from the roots of Garcinia polyantha, and identified. Two of them, the xanthone garciniaxanthone I (1), and the triterpene, named garcinane (2), are reported as new natural products. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR spectroscopic studies. Th... | 18,997,392 |
Synthetic studies on kohamaic acids: synthesis of structurally simplified analogs of kohamaic acid A. | Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships. | 18,997,393 |
L-theanine elicits an umami taste with inosine 5'-monophosphate. | We investigated the taste synergy between L-theanine and the flavour enhancer, inosine 5'-monophosphate (IMP), by using a human sensory evaluation. When L-theanine was added to IMP, only the umami taste was enhanced. We then investigated this synergistic effect of L-theanine in mice by gustatory nerve recording. We con... | 18,997,398 |
Enhanced valine production in Corynebacterium glutamicum with defective H+-ATPase and C-terminal truncated acetohydroxyacid synthase. | We have reported increased glutamate production by a mutant of Corynebacterium glutamicum ATCC14067 (strain F172-8) with reduced H(+)-ATPase activity under biotin-limiting culture conditions (Aoki et al. Biosci. Biotechnol. Biochem., 69, 1466-1472 (2005)). In the present study, we examined valine production by an H(+)-... | 18,997,402 |
The natural compound ascorbigen modulates NADPH-quinone oxidoreductase (NQO1) mRNA and enzyme activity levels in cultured liver cells and in laboratory rats. | Ascorbigen (ABG) is a natural compound that represents a breakdown product of the glucosinolates that are present in Brassica vegetables. It is postulated that ABG may have anticarcinogenic activity; however, the underlying molecular and cellular mechanisms are largely unknown. In the present study we investigated the ... | 18,997,460 |
Higher-level hand motor function in aging and (preclinical) dementia: its relationship with (instrumental) activities of daily life--a mini-review. | A causal relationship between physical activity such as walking and cognitive functions - particularly executive functions and memory - has been observed in elderly people with and without dementia. Executive functions play an important role in the (instrumental) activities of daily life [(I)ADL]. However, a close rela... | 18,997,468 |
Biological correlates of the congruence and incongruence of psychotic symptoms in patients with type 1 bipolar disorder. | We examined the catechol-O-methyl transferase (COMT) Val108/158Met genotype in 160 type 1 bipolar patients. We also analyzed the plasma concentrations of homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylethylenglycol (MHPG) and 3,4-dihydroxyphenylacetic acid in 60 of those patients who had been without mood stabilizer... | 18,997,477 |
Assessing new graduate nurse performance. | New graduate nurses now comprise more than 10% of a typical hospital's nursing staff, with this number certain to grow given the increasing numbers of entrants into the nurse workforce. Concomitantly, only 10% of hospital and health system nurse executives believe their new graduate nurses are fully prepared to provide... | 18,997,551 |
Shaken baby syndrome education program: nurses making a difference. | This article describes the nursing role in the Upstate New York Shaken Baby Syndrome (SBS) Education Program, an effort to educate parents of all hospital-born infants in the eight-county region of Western New York about the dangers of violent infant shaking. This program has now been expanded to include hospitals in 1... | 18,997,573 |
The hospital-based adoption process: a primer for perinatal nurses. | Although the number of women who relinquish their infants is declining, it is estimated that over 52,000 young women pursue an adoption plan every year. Perinatal nurses practicing in any facet of perinatal care may provide care for a woman implementing an adoption plan for her infant. The provision of care may include... | 18,997,575 |
Simultaneous magnetoencephalography and intracranial EEG registration: technical and clinical aspects. | The purpose of this study was to describe the methodology necessary for simultaneous recording of intracranial EEG (ICEEG) and magnetoencephalography (MEG) and to assess the sensitivity of whole-head MEG versus depth electrode EEG in the detection and localization of epileptic spikes. Interictal MEG and depth electrode... | 18,997,623 |
Intravitreal voriconazole: in vitro safety-profile for fungal endophthalmitis. | Fungal endophthalmitis is a rare but sight-threatening disease. Despite an expanding range of fungal pathogens, there are only few therapeutic agents for its treatment available. Voriconazole is a second-generation synthetic triazole with a broad action against yeasts and molds. The current study investigates the safet... | 18,997,637 |
Effect of caffeine supplementation on repeated sprint running performance. | This study examined the effects of 6 mgxkg(-1) caffeine ingestion in team-sport players (N.=10) on repeated-sprint running performance (5 sets of 6 x 20 m) and reaction times, 60 min after caffeine or placebo ingestion. Best single sprint and total set sprint times, blood lactate and simple and choice reaction times (R... | 18,997,650 |
Spinal curvature: comparison of frontal measurements with the Spinal Mouse and radiographic assessment. | The Spinal Mouse is an external non-invasive device which measures the spinal shape and mobility of the spine in several planes. The aim of the present study was to evaluate the reliability and the validity of the Spinal Mouse to assess frontal standing measurements of the spine in a sample of young healthy volunteers.... | 18,997,653 |
Capacity for physical activity predicts weight loss after Roux-en-Y gastric bypass. | Despite its overall excellent outcomes, weight loss after Roux-en-Y gastric bypass (RYGB) is highly variable. We conducted this study to identify clinical predictors of weight loss after RYGB. We reviewed charts from 300 consecutive patients who underwent RYGB from August 1999 to November 2002. Data collected included ... | 18,997,674 |
Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene. | Because information on weight changes after lifestyle intervention in children with mutations in the melanocortin 4 receptor (MC4R) gene is scarce, we compared weight changes after lifestyle intervention between children with and without MC4R variations. A group of 514 overweight children (aged 5-16 years), who present... | 18,997,677 |
Becoming physically active after bariatric surgery is associated with improved weight loss and health-related quality of life. | The purpose of this study was to determine whether pre- to postoperative increases in physical activity (PA) are associated with weight loss and health-related quality of life (HRQoL) following bariatric surgery. Participants were 199 Roux-en-Y gastric bypass (RYGB) surgery patients. The International Physical Activity... | 18,997,679 |
Validation of overweight children's fruit and vegetable intake using plasma carotenoids. | Assessing dietary intake in children is difficult and limited validated tools exist. Plasma carotenoids are nutritional biomarkers of fruit and vegetable intake and therefore suitable to validate reported dietary intakes. The aim of this study was to examine the comparative validity of a food frequency questionnaire (F... | 18,997,681 |
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. | Angiogenesis and the development of a vascular network are required for tumour progression, and they involve the release of angiogenic factors, including vascular endothelial growth factor (VEGF-A), from both malignant and stromal cell types. Infiltration by cells of the myeloid lineage is a hallmark of many tumours, a... | 18,997,773 |
Structure of a Shigella effector reveals a new class of ubiquitin ligases. | Bacterial pathogens have evolved effector proteins with ubiquitin E3 ligase activities through structural mimicking. Here we report the crystal structure of the Shigella flexneri type III effector IpaH3, a member of the leucine-rich repeat (LRR)-containing bacterial E3 family. The LRR domain is structurally similar to ... | 18,997,779 |
Incidence of nontuberculous mycobacteria in four hot water systems using various types of disinfection. | The objective of this study was to determine the incidence of nontuberculous mycobacteria (NTM) in hot water systems of 4 selected hospital settings. The hospitals provided the following types of disinfection for their hot water systems: hydrogen peroxide and silver, thermal disinfection, chlorine dioxide, and no treat... | 18,997,845 |
Identification of immunoreactive extracellular proteins of Streptococcus agalactiae in bovine mastitis. | Streptococcus agalactiae is a common pathogen that causes bovine mastitis. The aims of this study were to evaluate the antibody response against S. agalactiae extracellular proteins in the whey and serum of naturally infected bovines and to identify possible immunodominant extracellular antigens. IgG1 antibodies agains... | 18,997,846 |
Phylloepiphytic interaction between bacteria and different plant species in a tropical agricultural system. | Plant surfaces are a favourable niche for bacterial establishment, and hypothetically, plant species differ in their capacity to harbour epiphytic bacterial communities. This study was conducted to evaluate and describe the structural relationship of a bacterial community at the phyllosphere level with different plant ... | 18,997,848 |
In vitro activity of essential oils extracted from plants used as spices against fluconazole-resistant and fluconazole-susceptible Candida spp. | In the present study, the antifungal activity of selected essential oils obtained from plants used as spices was evaluated against both fluconazole-resistant and fluconazole-susceptible Candida spp. The Candida species studied were Candida albicans, Candida dubliniensis, Candida tropicalis, Candida glabrata, and Candid... | 18,997,851 |
Comparison of enzymatic antioxidant defence systems in different metabolic types of yeasts. | The enzymatic defence system in the 2 yeasts Kluyveromyces marxianus and Rhodotorula glutinis, differing in their mode of oxygen uptake and energy generation, was characterized and compared with the well-studied facultatively fermentative Crabtree-positive Saccharomyces cerevisiae strain. Twofold higher superoxide dism... | 18,997,852 |
Glomus tumors of the hand. | The purpose of this study is to present a review of the current understanding of glomus tumors of the hand. Clinical cases are used to demonstrate the relevance of history and physical examination in deriving the diagnosis of this rare, but important entity. Treatment, complications, and review of the literature are pr... | 18,997,858 |
[Distinctive features of split treatments among psychiatrists and psychotherapists in Buenos Aires City and its surroundings]. | although psychopharmacotherapy and psychotherapy are very frequent in Buenos Aires city and its surroundings, there is no data about their combination. an anonymous survey was used to bring up psychiatrists and psychotherapists opinions upon combined, integrated and split treatments. 411 persons answered the survey; 95... | 18,997,901 |
Impact of a novel power toothbrush with SmartGuide technology on brushing pressure and thoroughness. | Toothbrushing effectiveness can be improved with at-home reinforcement of proper technique. This study evaluated the ability of a power brush with a wireless remote display (Oral-B Triumph with SmartGuide) to improve brushing force and thoroughness. At baseline, 61 pre-screened subjects were videotaped while brushing. ... | 18,997,910 |
Comparison of the antibacterial activity of different self-etching primers and adhesives. | The aim of this study was to evaluate the antibacterial effects of different one-step and two-step self-etching primer/adhesives on Streptococcus mutans (S. mutans), Lactobacillus casei (L. casei), and Lactobacillus acidophilus (L. acidophilus). The antibacterial effects of Clearfil Protect Bond Primer and Bonding agen... | 18,997,917 |
Influence of location of the gingival margin on the microleakage and internal voids of nanocomposites. | The aim of this in vitro study was to investigate the cervical microleakage and internal voids of nanocomposites comparing them with a hybrid composite in Class II restorations with the margins located coronal and apical to the cementoenamel junction (CEJ). Standardized MOD cavities (one cervical margin located in dent... | 18,997,918 |
1-Azadienes in cycloaddition and multicomponent reactions towards N-heterocycles. | 1-Azadienes are versatile building blocks for the efficient construction of various N-heterocycles. Depending on the substitution pattern and reaction partner, they may participate in a range of different reactions. An overview of recent methods for the generation of 1-azadienes is presented, as well as their applicati... | 18,997,927 |
Greatly reduced amino acid alphabets in directed evolution: making the right choice for saturation mutagenesis at homologous enzyme positions. | Enantioselective mutants of the thermally robust phenyl acetone monooxygenase (PAMO) as catalysts in Baeyer-Villiger reactions have been evolved by utilizing saturation mutagenesis in which drastically reduced amino acid alphabets are employed at homologous enzyme positions. | 18,997,931 |
Coordination networks derived from germanium(ii) thioether macrocyclic complexes-the first authenticated chalcogenoether complexes of Ge(ii). | Exocyclic coordination of macrocyclic thioethers to germanium(ii) halides leads to infinite chains (with weak GeX bridges between the chains) or sheet structures containing distorted octahedral Ge(ii) with [S(2)X(2) + X(2)] coordination and bridging thiacrowns. | 18,997,934 |
The first synthesis of N-acetylneuraminic acid 1,7-lactone. | N-Acetylneuraminic acid is transformed into its until now unavailable and rather unwieldy 1,7-lactone, via the manageable 2-benzyloxycarbonyl N-acetylneuraminic acid 1,7-lactone which generates the free lactone in quantitative yield by hydrogenolysis. | 18,997,937 |
Complete oxidation of acetaldehyde and toluene over a Pd/WO(3) photocatalyst under fluorescent- or visible-light irradiation. | Acetaldehyde was completely oxidized to CO(2) over a Pd/WO(3) photocatalyst under fluorescent-light irradiation in a flow-type reactor, and Pd/WO(3) was also used to completely oxidize toluene to CO(2) in a batch reactor under visible-light irradiation. | 18,997,953 |
Synthesis of 3-hydroxy-1-alkenylboronates via phosphine stabilized borylzirconacyclopropenes. | Zirconacyclopropenylboronates can be stabilized to dimerization by complexation with tributylphosphine; the phosphine stabilized zirconacycle boronates react with aliphatic and aromatic ketones and aldehydes at C2 of the triple bond to give the previously unknown 3-hydroxyvinylboronates in 61-80% isolated yields. | 18,997,961 |
In vivo studies of a platinum(II) metallointercalator. | An in vivo study for determining the toxicity and efficacy of [Pt(S,S-dach)(phen)Cl(2).1.5H(2)O.0.5HCl (PHENSS) in female Specific Pathogen Free (SPF) Swiss nude mice bearing PC3 tumour xenografts revealed PHENSS to be non-toxic and effective in decreasing tumour growth. | 18,997,969 |
A facile strategy to control polymer topology by variation of controlled radical polymerization mechanisms. | A facile strategy for control of the polymer topologies can be achieved simply by tuning the feed molar ratio of catalyst to transfer agent in the controlled radical polymerization. | 18,997,978 |
(kappa(2)-P,S)Pt(benzyl) complexes derived from 1/3-P(i)Pr(2)-2-S(t)Bu-indene: facile synthesis of carbanion- and borate-containing zwitterions. | The versatile new ligand precursor 1/3-P(i)Pr(2)-2-S(t)Bu-indene has been employed in the preparation of neutral and cationic (kappa(2)-P,S)Pt(benzyl) complexes, as well as structurally related zwitterions in which the formally cationic metal fragment is counterbalanced by an uncoordinated indenide or borate fragment t... | 18,997,980 |
Cardiovascular effects of Helichrysum ceres S Moore [Asteraceae] ethanolic leaf extract in some experimental animal paradigms. | The aim of this study was to examine some in vivo and in vitro cardiovascular effects of Helichrysum ceres leaf ethanolic extract (HCE) in experimental animal paradigms. The acute effects of HCE on blood pressure were studied in anaesthetised normotensive male Wistar rats challenged with intravenous hypotonic saline in... | 18,997,985 |
Expression of survivin in invasive pituitary adenoma. | To investigate the relationship between survivin expression and invasiveness of pituitary adenoma. A total of 66 patients, on whom trans sphenoidal surgery had been performed between July 2006 and March 2008, were enrolled in our study at the Department of Neurosurgery in Shandong Provincial Hospital and Jinan Central ... | 18,998,006 |
Nitroblue tetrazolium test in patients with beta-thalassemia major. | To assess the neutrophil function in thalassemia major (TM) patients and compare it with the control group, and to recognize its relevant factors. This was a retrospective cohort study, which was carried out from October 2007 to February 2008 in the Thalassemia Research Center in Boo Ali Sina Hospital in Sari, Mazandar... | 18,998,009 |
[Development of docetaxel in the adjuvant chemotherapy of breast cancer]. | The development of taxanes in cancer chemotherapy required several decades of research mainly because of the difficulty related to supply and formulation of paclitaxel. Lesser difficulty was encountered in the development of docetaxel, which initially took place in breast cancer. In this disease, docetaxel showed a sig... | 18,998,039 |
Osmosensing and osmosignaling in the liver. | Alterations of hepatocyte volume induced by either anisoosmotic environments or under the influence of hormones, concentrative amino acid uptake and oxidative stress are now recognized as an independent signal which contributes to the regulation of liver cell function and gene expression. Several long-known but mechani... | 18,998,070 |
Reactive oxygen species facilitate the insulin-dependent inhibition of glucagon-induced glucose production in the isolated perfused rat liver. | Recent studies indicate that intracellular insulin signalling involves the formation of reactive oxygen species (ROS) by NADPH oxidases (NOX). ROS inhibit intracellular protein tyrosin phosphatases whereby phosphoprotein signalling is enhanced and prolonged. We used the isolated perfused rat liver and detected ROS form... | 18,998,075 |
Pancreatic stellate/myofibroblast cells express G-protein-coupled melatonin receptor 1. | In chronic pancreatitis and pancreatic cancer, progressive fibrosis with the accumulation of extracellular matrix occurs. The main extracellular matrix-producing cell types are retinoid-storing pancreatic stellate cells (PSCs) of mesenchymal origin. Similar to liver stellate cells, quiescent PSCs undergo activation and... | 18,998,076 |
Chemiluminescence assays to investigate membrane expression and clathrin-mediated endocytosis of K(ATP) channels. | Macroscopic ion channel currents (I) are a product of the channel open probability (P (o)), the single channel current (i) and the number of channels present on the cell surface (N) at any given time (I = P (o) iN). Endocytosis has been shown to be one of the key determinants of cell surface channel density and the def... | 18,998,083 |
[Pylorus-preserving pancreatic head resection: a new standard for tumors]. | Traverso-Longmire pylorus-preserving pancreatic head resection is regarded as the standard surgical procedure for pancreatic head tumors. The mortality, morbidity, and oncological radicality are as low as with the classic Kausch-Whipple resection, with the additional advantage of shorter operating time and reduced bloo... | 18,998,104 |
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