title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
|---|---|---|
Signaling pathways open the GAITway to translational control. | In activated monocytes, Interferon-gamma modulates assembly of a heterotetrameric inhibitor of translation. This is responsive to signaling cascades promoting the induction and activation of death associated protein kinase (DAPK) and consequently zipper-interacting protein kinase (ZIPK). Now Mukhopadhyay et al., in a r... | 19,000,828 |
Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. | The Nup107-160 complex, the largest subunit of the nuclear pore, is multifunctional. It mediates mRNA export in interphase, and has roles in kinetochore function, spindle assembly, and postmitotic nuclear pore assembly. We report here that the levels of constituents of the Nup107-160 complex are coordinately cell cycle... | 19,000,832 |
Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila. | The gene networks regulating heart morphology and cardiac integrity are largely unknown. We previously reported a role for the heterotrimeric G protein gamma subunit 1 (Ggamma1) in mediating cardial-pericardial cell adhesion in Drosophila. Here we show G-oalpha47A and Gbeta13F cooperate with Ggamma1 to maintain cardiac... | 19,000,835 |
Bmp2 signaling regulates the hepatic versus pancreatic fate decision. | Explant culture data have suggested that the liver and pancreas originate from common progenitors. We used single-cell-lineage tracing in zebrafish to investigate this question in vivo as well as to analyze the hepatic versus pancreatic fate decision. At early somite stages, endodermal cells located at least two cells ... | 19,000,838 |
Computerized counseling for folate knowledge and use: a randomized controlled trial. | Periconception folate supplementation significantly reduces the risk of neural-tube defects, but few U.S. women start folate supplementation before pregnancy, and the amount of clinician time available to counsel patients about folate is limited. This study evaluated whether computer-assisted counseling and the provisi... | 19,000,845 |
Mid-life suicide: an increasing problem in U.S. Whites, 1999-2005. | The overall suicide rate in the U.S. increased by 6% between 1981 and 1986 and declined by 18% between 1986 and 1999. Detailed descriptions of recent trends in suicide are lacking, especially with regard to the method of suicide. Information is needed on the major changes in rates of suicide in specific population grou... | 19,000,847 |
Complete decontamination and regeneration of DNA purification silica columns. | Silica columns are among the most used DNA purification systems, allowing a good yield of high-quality nucleic acids without organic extractions. Silica column regeneration protocols reported up to now to remove DNA traces are time-consuming, and their effectiveness on genomic DNA has not been demonstrated. Here we rep... | 19,000,895 |
TREP, a novel protein necessary for gliding motility of the malaria sporozoite. | The invasive stages of parasites of the protozoan phylum Apicomplexa have the capacity to traverse host tissues and invade host cells using a unique type of locomotion called gliding motility. Gliding motility is powered by a sub-membranous actin-myosin motor, and the force generated by the motor is transduced to the p... | 19,000,911 |
A proteomic analysis of the aphid Macrosiphum euphorbiae under heat and radiation stress. | Temperature and solar radiation can be important sources of abiotic stress for small herbivorous insects living in close association with plants. We examined the effects of daily fluctuations of heat and UV radiation on the proteome and performance of winged and wingless morphs of the aphid Macrosiphum euphorbiae. A da... | 19,000,926 |
High yielding recombinant Staphylokinase in bacterial expression system--cloning, expression, purification and activity studies. | Staphylokinase (SAK) is emerging as an important thrombolytic agent. In this report, we describe the cloning, expression, purification and activity studies of the SAK gene of Staphylococcus aureus from a custom synthesised SAK gene. The SAK gene of 411 bp yielded a protein of approximately 15 kDa when expressed under p... | 19,000,928 |
Correlates of response to Olanzapine in a North Indian Schizophrenia sample. | Olanzapine is widely used for the treatment of schizophrenia and is considered a first line medication in India. Along with other factors, the variation in response and side effects to this agent may be accounted for by genetic differences among patients. Olanzapine was administered for 6 weeks to Indian subjects with ... | 19,000,940 |
Evaluation of a telemedicine-based service for the follow-up and monitoring of patients treated with oral anticoagulant therapy. | The authors have designed and developed a telemedicine-based service for the follow-up and monitoring of patients on oral anticoagulant therapy (OAT) that consists of two phases; the first involving self-testing and the second involving guided self-management. To evaluate the first phase of the protocol, a project was ... | 19,000,948 |
Recursive fuzzy granulation for gene subsets extraction and cancer classification. | A typical microarray gene expression dataset is usually both extremely sparse and imbalanced. To select multiple highly informative gene subsets for cancer classification and diagnosis, a new Fuzzy Granular Support Vector Machine---Recursive Feature Elimination algorithm (FGSVM-RFE) is designed in this paper. As a hybr... | 19,000,951 |
Detections of arterial wall in sonographic artery images using dual dynamic programming. | We propose a novel dual dynamic programming (DDP) technique for detecting intimal and adventitial layers of the common carotid artery of the B-mode sonographic images. This method embeds the anatomic knowledge into its structure so that the robustness against the speckles is increased. Moreover, it inherits the propert... | 19,000,960 |
Anti-atherogenic and anti-inflammatory properties of high-density lipoprotein are affected by specific antibodies in systemic lupus erythematosus. | To determine whether antibodies against high-density lipoprotein (aHDL) and apolipoprotein A-I (aApo A-I) interfere with the anti-atherogenic functions of high-density lipoprotein (HDL) and relate to disease activity and damage in SLE. Seventy-seven SLE patients were compared with an age- and sex-frequency matched cont... | 19,000,993 |
Serum intact parathyroid hormone levels predict hospitalisation for heart failure. | To assess whether circulating levels of intact parathyroid hormone (intact PTH) in outpatients predict hospitalisation for heart failure (HF). Eighty-eight consecutive outpatients with HF were enrolled in the study. The independent association between intact PTH and hospitalisation for HF was assessed using Cox regress... | 19,001,003 |
The role of primary care in promoting children's physical activity. | Regular physical activity enhances health during childhood and adolescence and is important in setting the stage for participation in physical activity across the lifespan. Physician-patient interactions during childhood and adolescence provide important opportunities for clinicians to influence physical activity behav... | 19,001,016 |
A comparison of Canadian pediatric resident career plans in 1998 and 2006. | Studies of pediatric resident career plans and preferences help to forecast changes in the demographic profile and practice patterns of North American pediatricians, providing insights that can guide child health care and medical education policy making. With this study we aimed to compare 4 aspects of Canadian pediatr... | 19,001,036 |
Increased reverse triiodothyronine is associated with shorter survival in independently-living elderly: the Alsanut study. | Increased reverse tritiodothyronine (T(3)) used to be described as a part of euthyroid sick syndrome (ESS). It was demonstrated to be associated with increased mortality in acutely ill patients. It can also be found with low or normal T(3) in non-severely ill subjects but its significance remains unclear. The Alsanut s... | 19,001,060 |
Borrelia burgdorferi infection-associated surface proteins ErpP, ErpA, and ErpC bind human plasminogen. | Host-derived plasmin plays a critical role in mammalian infection by Borrelia burgdorferi. The Lyme disease spirochete expresses several plasminogen-binding proteins. Bound plasminogen is converted to the serine protease plasmin and thereby may facilitate the bacterium's dissemination throughout the host by degrading e... | 19,001,079 |
Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. | The intracellular signaling mechanisms underlying the pathogenesis of cardiac diseases are not fully understood. We report here that selective deletion of Shp2, an SH2-containing cytoplasmic tyrosine phosphatase, in striated muscle results in severe dilated cardiomyopathy in mice, leading to heart failure and premature... | 19,001,090 |
Relationship between the presence of practice systems and the quality of care for depression. | A valid measure of practice systems for improving chronic disease care is needed as a guide for both improvement and public accountability. We tested whether a new survey measure of the presence of practice systems (the PPC-R) is associated with performance measure rates for depression among 40 medical groups in Minnes... | 19,001,099 |
Vancomycin ototoxicity: a reevaluation in an era of increasing doses. | Nephrotoxicity and ototoxicity have historically been documented as relatively rare complications of vancomycin monotherapy. Recent reports have linked aggressive vancomycin dosing strategies to significant risks of nephrotoxicity. We evaluated the rate of high-frequency hearing loss detected by audiometry for patients... | 19,001,107 |
Maternal smoking, preeclampsia, and infant health outcomes in New York City, 1995-2003. | A number of previous studies have reported an inverse association between maternal smoking and preeclampsia. Additionally, some have suggested that smokers who develop preeclampsia have worse maternal and fetal outcomes than nonsmokers who develop preeclampsia. The authors examined the relation of smoking to preeclamps... | 19,001,134 |
The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. | The survival rate of patients diagnosed with late-stage melanoma is poor--only 5%-10%. Enlisting the immune system in the fight against cancers such as melanoma could help improve the prognosis of these patients. Data have shown that melanocyte proteins make good targets for immune system-based therapy in this disease.... | 19,001,145 |
Patent foramen ovale: diagnosis with multidetector CT--comparison with transesophageal echocardiography. | To evaluate the clinical feasibility and accuracy of 64-section multidetector computed tomography (CT) compared with transesophageal echocardiography (TEE) for diagnosis of a patent foramen ovale (PFO). Institutional review board approval was obtained for this retrospective study. The study included 152 consecutive str... | 19,001,153 |
TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. | Recently, TAR DNA-binding protein 43 (TDP-43) was identified as the major component of ubiquitin-positive tau-negative neuronal and glial inclusions in the most common form of frontotemporal lobar degeneration (FTLD) and in amyotrophic lateral sclerosis (ALS). It was demonstrated that different TDP-43 profiles correspo... | 19,001,167 |
Deletion of inducible nitric oxide synthase provides cardioprotection in mice with 2-kidney, 1-clip hypertension. | Inducible NO synthase (iNOS) has been implicated in the pathogenesis of hypertension and target organ damage. We hypothesized that induction of iNOS contributes to left ventricular (LV) hypertrophy and dysfunction in mice with 2-kidney, 1-clip hypertension. Deletion of iNOS diminishes oxidative stress, thereby attenuat... | 19,001,185 |
Somatostatin 2A receptor-expressing presympathetic neurons in the rostral ventrolateral medulla maintain blood pressure. | Bulbospinal neurons in the rostral ventrolateral medulla (RVLM) are critical for the maintenance of sympathetic vasomotor tone and normal cardiovascular reflex function. So far, selectively eliminating/inhibiting distinct subpopulations of RVLM neurons has not significantly altered arterial pressure. Here we show that ... | 19,001,189 |
Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-Plus Study. | Screening for deficiencies in vitamin B(12) and folate is advocated to prevent anemia in very elderly individuals. However, the effects of vitamin B(12) and folate deficiency on the development of anemia in old age have not yet been established. The current study is embedded in the Leiden 85-Plus Study, a population-ba... | 19,001,201 |
Plaque radiotherapy for juxtapapillary choroidal melanoma overhanging the optic disc in 141 consecutive patients. | To evaluate tumor control with plaque radiotherapy for juxtapapillary choroidal melanoma that overhangs the optic disc. Retrospective medical record review of 141 consecutive patients with data on complications of treatment, final visual acuity, visual loss, enucleation, tumor recurrence, metastasis, and death. The med... | 19,001,218 |
Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis. | Treatment of yeast and human cells with DNA-damaging agents elicits Rad6-Rad18-mediated monoubiquitination of proliferating cell nuclear antigen (PCNA) at its Lys-164 residue [ubiquitin (Ub)-PCNA], and this PCNA modification is indispensable for promoting the access of translesion synthesis (TLS) polymerases (Pols) to ... | 19,001,268 |
Impact of XIAP protein levels on the survival of myeloma cells. | XIAP is the best characterized and the most potent direct endogenous caspase inhibitor and is considered a key actor in the control of apoptotic threshold in cancer cells. In this report, we specifically addressed XIAP regulation and function in myeloma cells. XIAP and its endogenous inhibitor XAF-1 protein levels and ... | 19,001,278 |
Progressive loss of DNA methylation releases epigenetic gene silencing from a tandemly repeated maize Myb gene. | Maize pericarp color1 (p1) gene, which regulates phlobaphene biosynthesis in kernel pericarp and cob glumes, offers an excellent genetic system to study tissue-specific gene regulation. A multicopy p1 allele, P1-wr (white pericarp/red cob) is epigenetically regulated. Hypomethylation of P1-wr in the presence of Unstabl... | 19,001,287 |
Physicians' experiences with BRCA1/2 testing in community settings. | We surveyed a national sample of nonacademic physicians who ordered BRCA1/2 testing to understand their implementation of genetic testing and to assess recommendations for surveillance and cancer risk management of women with positive test results. We surveyed physicians (N = 611 of 1,050; response rate, 58.2%) practic... | 19,001,322 |
Association of serum interleukin-7 levels with the development of acute graft-versus-host disease. | Morbidity from acute graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic stem-cell transplantation (HSCT) to treat malignancy. Interleukin-7 (IL-7), the principal homeostatic cytokine for T cells, is required for acute GVHD in murine models. In contrast to inflammatory cytokines (eg, IL-2, t... | 19,001,329 |
Simulation of neuronal death and network recovery in a computational model of distributed cortical activity. | The authors utilize a model of activity-dependent neuronal plasticity to study the interplay between synaptogenesis, neuronal death, and neurogenesis on the resulting pattern of neuronal connectivity. A mathematical model of neuronal network activity was employed, with plasticity instantiated by an activity-dependent r... | 19,001,355 |
Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation. | Based on the structural information of acetylaszonalenin isolated from Neosartorya fischeri, a putative biosynthetic gene cluster was identified in the genome sequence of this fungus by genomic mining. This cluster consists of three genes coding for a putative non-ribosomal peptide synthetase (AnaPS), a prenyltransfera... | 19,001,367 |
3-mercaptopropionate dioxygenase, a cysteine dioxygenase homologue, catalyzes the initial step of 3-mercaptopropionate catabolism in the 3,3-thiodipropionic acid-degrading bacterium variovorax paradoxus. | The thioether 3,3-thiodipropionic acid can be used as precursor substrate for biotechnological synthesis of 3-mercaptopropionic acid-containing polythioesters. Therefore, the hitherto unknown catabolism of this compound was elucidated to engineer novel and improved polythioester biosynthesis pathways in the future. Bac... | 19,001,372 |
The frizzled-related sFRP2 gene is a target of thyroid hormone receptor alpha1 and activates beta-catenin signaling in mouse intestine. | The thyroid hormone receptor TRalpha1 regulates intestinal development and homeostasis by controlling epithelial proliferation in the crypts. This involves positive control of the Wnt/beta-catenin pathway. To further investigate the effect of thyroid hormone-TRalpha1 signaling on the intestinal epithelium proliferating... | 19,001,373 |
Characterization of the differential roles of the twin C1a and C1b domains of protein kinase C-delta. | Classic and novel protein kinase C (PKC) isozymes contain two zinc finger motifs, designated "C1a" and "C1b" domains, which constitute the recognition modules for the second messenger diacylglycerol (DAG) or the phorbol esters. However, the individual contributions of these tandem C1 domains to PKC function and, recipr... | 19,001,377 |
Agreement rates for sleep/wake judgments obtained via accelerometer and sleep diary: a comparison. | Agreement rates for waking and sleeping obtained via sleep diary and accelerometer were evaluated, to compare the two methods. Sleep/wake data for consecutive days and nights were surveyed in 119 healthy university students. Accelerometer sleep/wake judgments obeyed the standard algorithm. Agreement rates for waking an... | 19,001,393 |
Taboo, emotionally valenced, and emotionally neutral word norms. | Although taboo words are used to study emotional memory and attention, no easily accessible normative data are available that compare taboo, emotionally valenced, and emotionally neutral words on the same scales. Frequency, inappropriateness, valence, arousal, and imageability ratings for taboo, emotionally valenced, a... | 19,001,397 |
The British Sign Language (BSL) norms for age of acquisition, familiarity, and iconicity. | Research on signed languages offers the opportunity to address many important questions about language that it may not be possible to address via studies of spoken languages alone. Many such studies, however, are inherently limited, because there exist hardly any norms for lexical variables that have appeared to play i... | 19,001,399 |
C-CAT: a computer software used to analyze and select Chinese characters and character components for psychological research. | The Character-Component Analysis Toolkit (C-CAT) software was designed to assist researchers in constructing experimental materials using traditional Chinese characters. The software package contains two sets of character stocks: one suitable for research using literate adults as subjects and one suitable for research ... | 19,001,401 |
Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria. | Previously, we demonstrated that mitochondria from denervated muscle exhibited dramatically higher Amplex Red dependent fluorescence (thought to be highly specific for hydrogen peroxide) compared with control muscle mitochondria. We now demonstrate that catalase only partially inhibits the Amplex Red signal in mitochon... | 19,001,413 |
Mechanisms associated with tolerance to flooding during germination and early seedling growth in rice (Oryza sativa). | Flooding slows seed germination, imposes fatalities and delays seedling establishment in direct-seeded rice. This study describes responses of contrasting rice genotypes subjected to flooding or low oxygen stress during germination and discusses the basis of tolerance shown by certain cultivars. In one set of experimen... | 19,001,425 |
Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells. | The flexible heteroarotinoid, SHetA2, is a novel compound with apoptosis-inducing and anticancer activities in vitro and in vivo. Our previous research showed that up-regulation of death receptor 5 plays a critical role in the mechanism of SHetA2-induced apoptosis in human lung cancer cells. The hypothesis of this stud... | 19,001,438 |
Psorospermin structural requirements for P-glycoprotein resistance reversal. | Resistance to chemotherapy reduces its effectiveness, resulting in increased mortality. Psorospermin, a natural product, is a topoisomerase II-directed DNA alkylating agent active against multidrug-resistant (MDR) cell lines, including multiple myeloma. In this study, the mechanism of the P-glycoprotein (P-gp) modulati... | 19,001,443 |
Surgical repair of coronary sinus atrial septal defect and supraventricular tachycardia. | A 67-year-old female had suffered from fatigue and palpitation. Cardiac examination revealed coronary sinus atrial septal defect, moderate mitral and tricuspid regurgitation, coronary artery disease, and supraventricular tachycardia with paroxysmal atrial fibrillation. Surgical repair of the anomaly, regurgitant valves... | 19,001,454 |
ProtorP: a protein-protein interaction analysis server. | The PROTORP server analyses protein-protein associations in 3D structures. The server calculates a series of physical and chemical parameters of the protein interaction sites that contribute to the binding energy of the association. These parameters include, size and shape, intermolecular bonding, residue and atom comp... | 19,001,476 |
Memory and attention problems in children with chronic fatigue syndrome or myalgic encephalopathy. | To understand more about the problems children with chronic fatigue syndrome (CFS) or myalgic encephalopathy (ME) experience with memory and attention, and to test the feasibility of quantitative measurement of both memory and attention. Four-item semistructured questionnaire and neuropsychological test battery with 10... | 19,001,478 |
Effects of nigral stimulation on locomotion and postural stability in patients with Parkinson's disease. | The physiopathology of gait and balance disorders in Parkinson's disease patients is still poorly understood. Levodopa treatment and subthalamic nucleus (STN) stimulation improve step length and walking speed, with less effect on postural instability. These disorders have been linked to dysfunction of the descending ba... | 19,001,482 |
uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro. | The urokinase receptor (uPAR) is involved in a series of pathological processes, from inflammation to cancer. We have analyzed in detail the role of uPAR and the mechanisms involved in keratinocyte behavior during wound healing by exploiting uPAR-knockout (KO) mice. In vivo, uPAR-KO mice showed delayed wound healing, w... | 19,001,498 |
The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes. | RUNX1/AML1 is required for definitive hematopoiesis and is frequently targeted by chromosomal translocations in acute myeloid leukemia (AML). The t(8;21)-related AML1-ETO fusion protein blocks differentiation of myeloid progenitors. Here, we show by immunofluorescence microscopy that during interphase, endogenous AML1-... | 19,001,502 |
Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro. | The clinically used somatostatin analogs, octreotide and lanreotide, act primarily by binding to somatostatin receptor 2 (sst2). In contrast, the novel multireceptor ligand pasireotide (SOM230) binds with high affinity to somatostatin receptor subtypes sst1, sst2, sst3, and sst5. SOM230 is currently under clinical eval... | 19,001,514 |
Impact of somatostatin analogs versus surgery on glucose metabolism in acromegaly: results of a 5-year observational, open, prospective study. | The aim of the study was to investigate the 5-yr impact of surgery and somatostatin analogs (SSA) on glucose metabolism in acromegaly. We conducted an observational, prospective, comparative, nonrandomized study. The 100 patients (48 women, 52 men; median age, 49 yr) in the study were grouped as follows for treatment: ... | 19,001,517 |
Pharmaceutical care for migraine and headache patients: a community-based, randomized intervention. | Despite the high prevalence of headache and migraine in the general population, many people do not receive adequate medical attention and treatment. To evaluate the effects of pharmaceutical care (defined as intensified structured counseling between patient and pharmacist, including the use of drug databases), for pati... | 19,001,531 |
Temporal and spatial development of axonal maturation and myelination of white matter in the developing brain. | Diffusion tensor imaging (DTI) has been widely used to investigate the development of white matter (WM). However, information about this development in healthy children younger than 2 years of age is lacking, and most previous studies have only measured fractional anisotropy (FA). This study used FA and radial and axon... | 19,001,533 |
Variability of homotopic and heterotopic callosal connectivity in partial agenesis of the corpus callosum: a 3T diffusion tensor imaging and Q-ball tractography study. | Little is known about the anatomic connectivity of callosal axons in individuals with partial agenesis of the corpus callosum (pAgCC). We used tractography based on both diffusion tensor imaging (DTI) and high angular resolution diffusion imaging (HARDI) to investigate interhemispheric white matter connectivity in pAgC... | 19,001,538 |
Management and control of hypertension and proteinuria in patients with advanced chronic kidney disease under nephrologist care or not: data from the AVENIR study (AVantagE de la Nephroprotection dans l'Insuffisance Renale). | Little is known about antihypertensive management and control of blood pressure (BP) and proteinuria in patients with chronic kidney disease (CKD). Data from a large observational study (AVENIR), carried out in Lorraine (France), were used to analyse antihypertensive treatment and control of BP and proteinuria in patie... | 19,001,561 |
Expression of H(+),K(+)-ATPase and glycopattern analysis in the gastric glands of Rana esculenta. | A multidisciplinary study involving lectin histochemistry, IHC, immuno-lectin blotting, and immunogold was carried out to determine the distribution of sugar residues in the glycoproteins of Rana esculenta oxynticopeptic cells. We considered animals in two experimental conditions, fasting and fed. It is known that, in ... | 19,001,639 |
Placenta accreta: spectrum of US and MR imaging findings. | Placenta accreta (PA) encompasses various types of abnormal placentation in which chorionic villi attach directly to or invade the myometrium. PA is a significant cause of maternal morbidity and mortality and is now the most common reason for emergent postpartum hysterectomy. Its prevalence has risen tenfold in the Uni... | 19,001,647 |
Pediatric MR cholangiopancreatography: principles, technique, and clinical applications. | High-quality magnetic resonance (MR) cholangiopancreatographic images are difficult to obtain in children due to the small caliber of the pediatric bile ducts and to motion artifacts. However, there has been ongoing improvement in image quality, thanks to better coil technology, increased speed of acquisition, refineme... | 19,001,651 |
Flat-panel volume CT: fundamental principles, technology, and applications. | Flat-panel volume computed tomography (CT) systems have an innovative design that allows coverage of a large volume per rotation, fluoroscopic and dynamic imaging, and high spatial resolution that permits visualization of complex human anatomy such as fine temporal bone structures and trabecular bone architecture. In s... | 19,001,655 |
From the archives of the AFIP: central nervous system infections associated with human immunodeficiency virus infection: radiologic-pathologic correlation. | Diseases of the central nervous system (CNS) in patients infected with the human immunodeficiency virus (HIV) result directly from HIV itself or from a variety of opportunistic agents. These infections include progressive multifocal leukoencephalopathy, toxoplasmosis, and cryptococcosis. A resurgence of tuberculosis an... | 19,001,657 |
Cripto localizes Nodal at the limiting membrane of early endosomes. | Cripto is a glycosylphosphatidylinositol (GPI)-anchored co-receptor of Nodal and several other transforming growth factor-beta (TGF-beta) family ligands. It contains an epidermal growth factor (EGF)-like motif and a Cripto-FRL1-Cryptic (CFC) domain, which are conserved in a family of EGF-CFC proteins. The EGF domain is... | 19,001,664 |
Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease. | The effects of dietary monosodium glutamate (MSG) on trans-fatty acid (TFA)-induced nonalcoholic fatty liver disease (NAFLD) are addressed in an animal model. We used Affymetrix microarray analysis to investigate hepatic gene expression and the contribution of visceral white adipose tissue (WAT) to diet-induced NAFLD. ... | 19,001,666 |
Assessment of dosimetrical performance in 11 Varian a-Si-500 electronic portal imaging devices. | Dosimetrical characteristics of 11 Varian a-Si-500 electronic portal imaging devices (EPIDs) in clinical use for periods ranging between 10 and 86 months were investigated for consistency of performance and portal dosimetry implications. Properties studied include short-term reproducibility, signal linearity with monit... | 19,001,691 |
Multi-ray-based system matrix generation for 3D PET reconstruction. | Iterative image reconstruction algorithms for positron emission tomography (PET) require a sophisticated system matrix (model) of the scanner. Our aim is to set up such a model offline for the YAP-(S)PET II small animal imaging tomograph in order to use it subsequently with standard ML-EM (maximum-likelihood expectatio... | 19,001,696 |
[Effect of fructose-1,6-diphosphete on myocardial preservation during pulmonary operations]. | To investigate the effect of fructose-1,6-diphosphete(FDP) on myocardial preservation in pulmonary operations. One hundred and six patients undergoing selective pulmonary lobectomy or segmentectomy were randomly divided into 2 groups with 53 patients each. FDP 200 mg/kg was infused intravenously before anesthesia in th... | 19,001,742 |
Vitamin A intake is inversely related with adiposity in healthy young adults. | Dietary intake, either through specific nutrients or representative food groups, can influence obesity-related oxidative stress markers. This study evaluated the potential associations between vitamin A intake and several anthropometrical, biochemical and dietary features in healthy young adults, emphasizing the putati... | 19,001,764 |
Sequence diversity of the Bla g 4 cockroach allergen, homologous to lipocalins, from Blattella germanica. | The cockroach allergen Bla g 4, a putative lipocalin, is known to exhibit frequent sequence variations. However, the previously reported cDNA sequences are truncated at the N terminus. This study was undertaken to investigate the mechanisms by which these sequence variations are generated. Rapid amplification of cDNA e... | 19,001,794 |
Porphyria cutanea tarda, hepatitis C, uroporphyrinogen decarboxylase and mutations of HFE gene. A case-control study. | Hemochromatosis gene (HFE) mutations and the hepatitis C virus (HCV) are known risk factors for porphyria cutanea tarda (PCT), but interactions with erythrocytic uroporphyrinogen decarboxylase (UROD) have seldom been addressed. In order to examine the links between these factors, we conducted a multicentre prospective ... | 19,001,803 |
Lifestyle drugs in old age--a mini-review. | Normal aging is no disease. The individual lifestyle may be responsible for a large fraction of the so-called 'age-related' changes. An increasing number of healthy individuals make use of 'lifestyle' drugs, such as nootropics, psychopharmaca, hormones and ecodrugs. In this respect, the fact that many people try to imp... | 19,001,804 |
Posttransplant immunosuppression in highly sensitized patients. | Recent desensitization protocols using the combination of plasmapheresis (PP) or immunoadsorption to remove donor-specific anti-HLA antibodies (DSA) and/or intravenous immunoglobulin (IVIG) and rituximab to downregulate antibody-mediated immune responses have made kidney transplantation feasible by abrogating cross-mat... | 19,001,811 |
[The gap between research and practice--a survey among participants in continuing medical education events]. | To investigate to which extent physicians participating in specialization and continuing medical education courses read clinical research articles and how relevant they deem this for their practical work. Physicians participating in courses on homeopathy (n = 96), acupuncture (n = 79), naturopathy (n = 75), family medi... | 19,001,823 |
Natural host relationships and genetic diversity of rodent-associated hantaviruses in southeastern Brazil. | Hantaviruses are rodent-borne RNA viruses that have caused hantavirus cardiopulmonary syndrome in several Brazilian regions. In the present study, geographical distribution, seroprevalence, natural host range, and phylogenetic relations of rodent-associated hantaviruses collected from seven counties of Southeastern Bra... | 19,001,829 |
Phosphate binder impact on bone remodeling and coronary calcification--results from the BRiC study. | Calcium-containing phosphate binders have been shown to increase the progression of vascular calcification in hemodialysis patients. This is a prospective study that compares the effects of calcium acetate and sevelamer on coronary calcification (CAC) and bone histology. 101 hemodialysis patients were randomized for ea... | 19,001,830 |
[Private or public dental care? Patients' perception and experience in Lithuania]. | To compare demographic and social groups of patients, their satisfaction with services in public and private dental institutions. A random sample of 3000 Lithuanian residents was selected; 1801 participants answered a postal questionnaire. The response rate was 60.0%. Univariate analysis, chi(2) criterion, z-test, and ... | 19,001,839 |
Influence of laser-welding and electroerosion on passive fit of implant-supported prosthesis. | This study investigated the influence of laser welding and electroerosion procedure on the passive fit of interim fixed implant-supported titanium frameworks. Twenty frameworks were made from a master model, with five parallel placed implants in the inter foramen region, and cast in commercially pure titanium. The fram... | 19,001,843 |
The orthodontic treatment in Lithuania: accessibility survey. | The objective of the present study was to assess the public accessibility of orthodontic care in Lithuania. In 2008, a request for the information about various aspects of public orthodontic care during 2000-2007 in Lithuania was submitted to the State Patients' Fund at the Ministry of Health. The data on the demograph... | 19,001,845 |
Specialization of the general transcriptional machinery in male germ cells. | In adult animals, spermatogenesis involves a continuous differentiation of the spermatogonial stem and progenitor cell population into mature sperm. A unique aspect of this developmental process is the germ cell-specific expression and function of paralogues of components of the general transcription machinery, notably... | 19,001,848 |
ATMINistrating ATM signalling: regulation of ATM by ATMIN. | The checkpoint kinase ATM (ataxia telangiectasia mutated) transduces genomic stress signals to halt cell cycle progression and promote DNA repair in response to DNA damage. We have recently identified an essential cofactor for ATM, ATMIN (for ATM INteractor). Several observations suggested that ATMIN plays a key role i... | 19,001,856 |
mTOR regulates autophagy-associated genes downstream of p73. | The p53 family consists of three transcription factors, p53, p63 and p73 that share domain architecture and sequence identity. The mTOR (mammalian target of rapamycin) kinase responds to growth factors and nutrient levels to regulate cellular growth and autophagy. Whereas p53 acts both upstream and downstream of mTOR, ... | 19,001,857 |
NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway. | NFBD1/MDC1, 53BP1 and BRCA1 are DNA damage checkpoint proteins with twin BRCT domains. In order to determine if they have redundant roles in responses to ionizing radiation, we used siRNA and shRNA to deplete NFBD1, 53BP1 and BRCA1 in single, double and triple combinations. These analyses were performed in early passag... | 19,001,859 |
Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma. | Primary open angle glaucoma (POAG) is a late onset disease usually accompanied by elevated intraocular pressure (IOP) that results from the failure of the trabecular meshwork (TM) to maintain normal levels of aqueous humor outflow resistance. Cells in the TM are subjected to chronic oxidative stress through reactive ox... | 19,001,861 |
Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes. | In eukaryotic cells, MCM, the minichromosome maintenance proteins, form a heterohexamer during G(1) phase in the cell cycle and constitute a DNA helicase activity at the onset of replication. MCM proteins are downregulated and dissociated from chromatin when cells exit the cell cycle. MCM proteins are upregulated frequ... | 19,001,876 |
Cardiovascular aging and exercise in healthy older adults. | Physical inactivity in an aging population is a major contributing factor to the rising numbers of older persons with chronic illnesses and disabilities. The purpose of this article is to review the relationship between physical inactivity and age-associated changes to the cardiovascular system, and provide guidance on... | 19,001,881 |
Ionizing radiation and risk of laryngeal cancer among German uranium miners. | Today it is uncontested that uranium miners are at increased risk of lung cancer, primarily owing to their exposure to radon. Whether they are also at an increased risk of cancer at other sites, especially in the respiratory tract, remains under discussion. The aim of the present study was to examine the laryngeal canc... | 19,001,899 |
Radiological concerns in operation of intense low-energy deuteron beams. | A 40-keV, 5-mA DC deuteron beam was operated at the SARAF with the purpose of characterizing the ion source and the low-energy beam transport system. We used this opportunity to address radiological concern of operating an intense deuteron beam. Fast and thermal neutrons produced via the D(d,n) reaction were measured i... | 19,001,902 |
Family caregiver support and hospitalizations of patients with heart failure. | This study aimed to expand understanding of hospitalizations involving patients with heart failure by considering characteristics of the caregiver as a facet of the problem. In face-to-face interviews, 41 caregivers registered agreement or disagreement on a Likert scale of items associated with caregiver depressive sym... | 19,001,918 |
Clinical value of echocardiographic assessment of coronary flow reserve after left anterior descending coronary artery stenting in an unselected population. | Transthoracic Doppler echocardiography is a valuable tool to measure coronary flow reserve (CFR) and detect in-stent restenosis (ISR) after percutaneous coronary angioplasty in selected series of patients. To assess the usefulness of coronary flow reserve measured by echocardiography in detecting significant (> or =... | 19,001,933 |
Extrusion of the device: a rare complication of the pacemaker implantation. | Skin erosion caused by the pacemaker is widely documented, but the complete extrusion of the device is very rare. We describe the case of a 54-year-old woman who was admitted to hospital because of skin erosion, followed by the complete extrusion of the pacemaker pulse generator out of the subcutaneous pocket. The pati... | 19,001,937 |
Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition on serum matrix metalloproteinase-13 and tissue inhibitor matrix metalloproteinase-1 levels as a sign of plaque stabilization. | Atherosclerotic plaques are composed of a lipid rich core, which is covered by a collagen rich fibrous cap. Rupture of the atherosclerotic plaque with superimposed thrombosis is the main cause of acute coronary syndromes, including acute myocardial infarction and unstable angina. The stability of the plaque depends on ... | 19,001,938 |
Controlled exposure to combined particles and ozone decreases heart rate variability. | This experiment was designed to test if controlled exposure to particles and ozone would result in decreased heart rate variability (HRV). Five asthmatic adults were exposed for 4 hours to; filtered-air, carbon and ammonium nitrate particles, and particles and ozone. Twenty-minute electrocardiograms were obtained befor... | 19,001,951 |
A clustering of injury behaviors. | Alcohol is a well-known risk factor for injury. A number of other behaviors are also associated with injury risk. We hypothesized that risky drinking would be associated with other high risk behaviors, thereby delineating a need for behavioral interventions in addition to alcohol. A consecutive sample of trauma patient... | 19,001,964 |
Preinjury beta blockers are associated with increased mortality in geriatric trauma patients. | Beta-blockade decreases mortality and morbidity in selected older patient populations undergoing noncardiac general surgery. We hypothesized that preinjury beta blockade would increase mortality in geriatric trauma patients, given beta-blockers inhibit patient's physiologic responses to hypovolemic shock. Patients olde... | 19,001,968 |
Early venous thromboembolism prophylaxis with enoxaparin in patients with blunt traumatic brain injury. | To determine the safety of early enoxaparin for venous thromboembolism (VTE) prophylaxis in patients with blunt traumatic brain injury (TBI). Prospective observational study of patients with TBI who received enoxaparin within 48 hours after admission. Brain computed tomography (CT) scans were obtained at the time of ad... | 19,001,969 |
Percutaneous fluoroscopically guided jejunostomy placement. | To describe our experience with fluoroscopically guided direct jejunostomy placement in patients with enterocutaneous fistula, or neoplastic or postsurgical changes of the stomach or duodenum that preclude traditional gastrostomy placement. Nineteen patients underwent percutaneous direct jejunostomy tube placement with... | 19,001,975 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.