title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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The impact of mental illness on cardiac outcomes: a review for the cardiologist. | Traditional cardiac risk factors, such as smoking, hypertension and obesity, are widely accepted contributors to the onset and progression of cardiovascular disease (CVD), one of the foremost causes of morbidity and mortality worldwide. Largely overlooked, however, is the impact of mental health on cardiac disease. Fro... | 19,004,512 |
Effects of initial iron corrosion rate on long-term performance of iron permeable reactive barriers: column experiments and numerical simulation. | Column experiments and numerical simulation were conducted to test the hypothesis that iron material having a high corrosion rate is not beneficial for the long-term performance of iron permeable reactive barriers (PRBs) because of faster passivation of iron and greater porosity loss close to the influent face of the P... | 19,004,521 |
Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease. | Amyloid plaques and tau neurofibrillary tangles, the pathological hallmarks of Alzheimer's disease (AD), begin accumulating in the healthy human brain decades before clinical dementia symptoms can be detected. There is great interest in how this pathology spreads in the living brain and its association with cognitive d... | 19,004,525 |
Synthesis, evaluation and 3D QSAR analysis of novel estradiol-RGD octapeptide conjugates with oral anti-osteoporosis activity. | To enhance the potency, reduce the side effects and improve oral property of estradiol in estrogen replacement therapy (ERT), 6 novel estradiol-RGD octapeptide conjugates have been prepared. In an ovariectomized mouse osteoporotic model, at an oral dosage of 110.3 nmol/kg per day, their anti-osteoporosis activity was s... | 19,004,530 |
Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery. | Podocalyxin expression on Ter119(+) erythroblasts is induced following administration of erythropoietin (Epo) or phenylhydrazine treatment, but is notably absent on committed erythroid progenitors during homeostatic red cell turnover. Following high-dose Epo administration in vivo, podocalyxin surface expression is upr... | 19,004,540 |
Assessing college students' perceptions of tolerance to alcohol using social cues: the Social Tolerance Index. | Increased tolerance to alcohol is considered a risk factor for developing future problems. While college students are considered a high-risk population in relation to alcohol use it is suggested that tolerance operates differently in this population than in chronic drinking samples. Individuals' perceptions about their... | 19,004,562 |
Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: a phase II study in locally advanced rectal cancer. | Preoperative chemoradiotherapy followed by surgery represents the standard of care for locally advanced rectal cancer (LARC). Cetuximab has proved activity in advanced colorectal cancer, and its incorporation in preoperative treatment may increase tumor downstaging. After biopsy and staging, uT3/uT4 N0/+ LARC received ... | 19,004,567 |
Treatment Cost Analysis Tool (TCAT) for estimating costs of outpatient treatment services. | A Microsoft Excel-based workbook designed for research analysts to use in a national study was retooled for treatment program directors and financial officers to allocate, analyze, and estimate outpatient treatment costs in the U.S. This instrument can also be used as a planning and management tool to optimize resource... | 19,004,576 |
Departments of corrections as purchasers of community-based treatment: a national study. | Community-based substance abuse treatment for offenders has been shown to reduce both substance use and recidivism. One strategy to ensure treatment availability for offenders is to have each state's Department of Corrections (DOC) fund treatment directly. Purchasing treatment implies regulation, but DOC as both a purc... | 19,004,602 |
Metastasis of oral cancer to the parotid node. | The parotid node is an uncommon site of metastasis in head and neck cancer. This study was intended to clarify the incidence and indicators of oral cancer metastases to the parotid node. We reviewed the records of 253 patients with oral carcinomas who had undergone a total of 289 neck dissections between April 2001 and... | 19,004,605 |
Do sex differences affect prefrontal cortex associated cognition in schizophrenia? | Cognitive deficits in schizophrenia, especially those related to prefrontal cortex (PFC) functions, influence functional outcome. There is evidence for sex differences in cognition in schizophrenia, but the results in the literature are still controversial. This study evaluated different modalities of working memory (W... | 19,004,617 |
The adsorption behavior of cationic surfactant onto human hair fibers. | Quaternary ammonium surfactants are important ingredients that are frequently formulated into hair care products to modify the properties of hair surface. The adsorption kinetics, isotherms and association structures of cationic surfactants on hair surface, however, are not fully understood due to the heterogeneous nat... | 19,004,622 |
Equipment failure: causes and consequences in endoscopic gynecologic surgery. | To determine the incidence of equipment failure in gynecologic endoscopy and investigate causes and consequences. A prospective observational single-center study between January and April 2006. Gynecologic surgery department of a university hospital. In all, 116 endoscopic interventions were included: 62 laparoscopies,... | 19,004,670 |
Mad science in art. | Cover artist Mike Butler discusses how he's influenced by science fiction and artists to create his unique digital art. | 19,004,678 |
From cells to cell processors: the integration of health and video games. | Healthcare offers special opportunities for the application of game research and technology. This was evident in the presentations at the 2007 Games for Health Conference. | 19,004,688 |
A multiresolution stochastic level set method for Mumford-Shah image segmentation. | The Mumford-Shah model is one of the most successful image segmentation models. However, existing algorithms for the model are often very sensitive to the choice of the initial guess. To make use of the model effectively, it is essential to develop an algorithm which can compute a global or near global optimal solution... | 19,004,702 |
Reliability estimation for statistical shape models. | One of the drawbacks of statistical shape models is their occasional failure to converge. Although visually this fact is usually easy to recognize, there is no automatic way to detect it. In this paper, we introduce a generic reliability measure for statistical shape models. It is based on a probabilistic framework and... | 19,004,714 |
Detection and segmentation of concealed objects in terahertz images. | Terahertz imaging makes it possible to acquire images of objects concealed underneath clothing by measuring the radiometric temperatures of different objects on a human subject. The goal of this work is to automatically detect and segment concealed objects in broadband 0.1-1 THz images. Due to the inherent physical pro... | 19,004,716 |
[The design of new protocols/what place for the pathology departments?]. | The pathologist's role in 2008 includes diagnosic, prognostic and predictive implications. Histopathologic criteria are still essential to manage the disease of cancer patients. They need to be based on standardized pathology reports and can use ancillary techniques such as immunohistochemistry and molecular biology. H... | 19,004,732 |
[Principles of intensive care in severe acute pancreatitis in 2008]. | Acute pancreatitis is a dynamic, often progressive disease; 14-20% require intensive care in its severe form due to multiorgan dysfunction and/or failure. This review was created using systematic literature review of articles published on this subject in the last 5 years. The outcome of severe acute pancreatitis is det... | 19,004,743 |
[The history, ingredients and effects of energy drinks]. | The market and the degree of the consumption of energy drinks is increasing every year, but only a few have global knowledge of their ingredients and actual physiological effects. Furthermore, the number of available publications that really go into the details in this topic is also rather poor. After a short historica... | 19,004,746 |
[Hemodynamic effects of N-acetylcysteine and ischemic preconditioning in a liver ischemia-reperfusion model]. | The aim of the study was to investigate whether repeated ischemic preconditioning or N-acetylcysteine (NAC) prevents ischemic-reperfusion injury as determined by having favourable hemodynamic effects during reperfusion in canine livers. The control group ( n = 10) underwent 60 minutes of hepatic ischemia followed by 18... | 19,004,747 |
Reproductive constraint is a developmental mechanism that maintains social harmony in advanced ant societies. | A hallmark of eusociality in ants is the reproductive division of labor between queens and workers. Yet, nothing is known about the molecular mechanisms underlying reproduction in this group. We therefore compared the developmental genetic capacity of queens and workers to reproduce in several eusocially advanced speci... | 19,004,767 |
Enhanced optical properties of chemical vapor deposited single crystal diamond by low-pressure/high-temperature annealing. | Single crystal diamond produced by chemical vapor deposition (CVD) at very high growth rates (up to 150 microm/h) has been successfully annealed without graphitization at temperatures up to 2200 degrees C and pressures <300 torr. Crystals were annealed in a hydrogen environment by using microwave plasma techniques f... | 19,004,770 |
Interactions between amino acid side chains in cylindrical hydrophobic nanopores with applications to peptide stability. | Confinement effects on protein stability are relevant in a number of biological applications ranging from encapsulation in the cylindrical cavity of a chaperonin, translocation through pores, and structure formation in the exit tunnel of the ribosome. Consequently, free energies of interaction between amino acid side c... | 19,004,772 |
Environmental and anthropogenic controls over bacterial communities in wetland soils. | Soil bacteria regulate wetland biogeochemical processes, yet little is known about controls over their distribution and abundance. Bacteria in North Carolina swamps and bogs differ greatly from Florida Everglades fens, where communities studied were unexpectedly similar along a nutrient enrichment gradient. Bacterial c... | 19,004,771 |
F-pili dynamics by live-cell imaging. | Bacteria have evolved numerous mechanisms for cell-cell communication, many of which have important consequences for human health. Among these is conjugation, the direct transfer of DNA from one cell to another. For gram-negative bacteria, conjugation requires thin, flexible filaments (conjugative pili) that are elabor... | 19,004,777 |
Crystal structures of the organomercurial lyase MerB in its free and mercury-bound forms: insights into the mechanism of methylmercury degradation. | Bacteria resistant to methylmercury utilize two enzymes (MerA and MerB) to degrade methylmercury to the less toxic elemental mercury. The crucial step is the cleavage of the carbon-mercury bond of methylmercury by the organomercurial lyase (MerB). In this study, we determined high resolution crystal structures of MerB ... | 19,004,822 |
The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation. | The level of the MafA transcription factor is regulated by a variety of effectors of beta cell function, including glucose, fatty acids, and insulin. Here, we show that phosphorylation at Ser(65) of mammalian MafA influences both protein stability and transactivation potential. Replacement of Ser(65) with Glu to mimic ... | 19,004,825 |
Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function. | Dermatan sulfate is a highly sulfated polysaccharide and has a variety of biological functions in development and disease. Iduronic acid domains in dermatan sulfate, which are formed by the action of two DS-epimerases, have a key role in mediating these functions. We have identified the catalytic site and three putativ... | 19,004,833 |
Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses. | Thrombospondin-1 regulates nitric oxide (NO) signaling in vascular cells via CD47. Because CD47 binding motifs are conserved in the C-terminal signature domains of all five thrombospondins and indirect evidence has implied CD47 interactions with other family members, we compared activities of recombinant signature doma... | 19,004,835 |
Tackling antibiotic resistance: a dose of common antisense? | Resistance to antimicrobial agents undermines our ability to treat bacterial infections. It attracts intense media and political interest and impacts on personal health and costs to health infrastructures. Bacteria have developed resistance to all licensed antibacterial agents, and their ability to become resistant to ... | 19,004,840 |
Fomepizole: a critical assessment of current dosing recommendations. | Fomepizole, 4-methylpyrazole (4-MP), is a competitive antagonist of alcohol dehydrogenase with a binding affinity >8000 times that of ethanol. The drug is currently labeled by the United States Food and Drug Administration for the treatment of adult patients with known or suspected ethylene glycol or methanol poison... | 19,004,845 |
Assessment of the CYP3A-mediated drug interaction potential of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy volunteers. | In this study, midazolam was used as a probe-sensitive CYP3A substrate to investigate the effect of anacetrapib on CYP3A activity, and ketoconazole was used as a probe-inhibitor to investigate the effect of potent CYP3A inhibition on the pharmacokinetics of anacetrapib, a novel cholesteryl ester transfer protein inhibi... | 19,004,846 |
Directing pathfinding along the dorsolateral path - the role of EDNRB2 and EphB2 in overcoming inhibition. | Neural crest cells that become pigment cells migrate along a dorsolateral route between the ectoderm and the somite, whereas most other neural crest cells are inhibited from entering this space. This pathway choice has been attributed to unique, cell-autonomous migratory properties acquired by neural crest cells when t... | 19,004,859 |
Unusual aortic stent complication after endovascular repair of the descending thoracic aorta in type B dissection in a patient with giant-cell arteritis. | The advent of endovascular prostheses to treat descending thoracic aortic lesions offers an alternative approach in patients who are poor candidates for surgery. We present a case of a type B descending thoracic aortic dissection with rapid aneurysmal evolution in a woman with a giant-cell arteritis, treated by endovas... | 19,004,862 |
Activation of renal renin-angiotensin system in upstream stimulatory factor 2 transgenic mice. | Previously we demonstrated that upstream stimulatory factor 2 (USF2) transgenic (Tg) mice developed nephropathy including albuminuria and glomerular hypertrophy, accompanied by increased transforming growth factor (TGF)-beta and fibronectin accumulation in the glomeruli. However, the mechanisms by which overexpression ... | 19,004,931 |
Human cytomegalovirus-encoded immune modulators partner to downregulate major histocompatibility complex class I molecules. | Throughout the course of natural evolution with its host, the human cytomegalovirus (HCMV) has developed a variety of strategies to avoid immune recognition and clearance. The major histocompatibility complex (MHC) class I antigen presentation pathway is a major target of the virus. HCMV encodes at least six gene produ... | 19,004,944 |
Analysis of the differential host cell nuclear proteome induced by attenuated and virulent hemorrhagic arenavirus infection. | Arenaviruses are important emerging pathogens and include a number of hemorrhagic fever viruses classified as NIAID category A priority pathogens and CDC potential biothreat agents. Infection of guinea pigs with the New World arenavirus Pichindé virus (PICV) has been used as a biosafety level 2 model for the Lassa viru... | 19,004,951 |
Does an altered leptin axis play a role in obesity among children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency? | Congenital adrenal hyperplasia (CAH) patients are at a higher risk to develop obesity. The role of leptin in CAH is still controversial. Our study aimed to evaluate serum levels of leptin, the soluble leptin receptor (sOB-R), and the sOB-R: leptin molar ratios in a cohort of CAH children and adolescents, and their asso... | 19,004,982 |
Is the olfactory bulb computationally similar to the retina? | The computational role of the olfactory bulb remains a mystery after 60 yr of physiological research. Recently, Fantana and colleagues proposed a new model of bulb function based on sparse inhibitory connections between glomeruli, the functional units of the bulb, rather than the existing lateral inhibition model. I pr... | 19,004,990 |
Random stimulation of spider mechanosensory neurons reveals long-lasting excitation by GABA and muscimol. | gamma-Aminobutyric acid type A (GABA(A)) receptor activation inhibits many primary afferent neurons by depolarization and increased membrane conductance. Deterministic (step and sinusoidal) functions are commonly used as stimuli to test such inhibition. We found that when the VS-3 mechanosensory neurons innervating the... | 19,004,993 |
Adjustments differ among low-threshold motor units during intermittent, isometric contractions. | We investigated the changes in muscle fiber conduction velocity, recruitment and derecruitment thresholds, and discharge rate of low-threshold motor units during a series of ramp contractions. The aim was to compare the adjustments in motor unit activity relative to the duration that each motor unit was active during t... | 19,004,996 |
Topography and response timing of intact cerebellum stained with absorbance voltage-sensitive dye. | Physiological activity of the turtle cerebellar cortex (Cb), maintained in vitro, was recorded during microstimulation of inferior olive (IO). Previous single-electrode responses to such stimulation showed similar latencies across a limited region of Cb, yet those recordings lacked spatial and temporal resolution and t... | 19,004,999 |
Thermodynamics and density of binding of a panel of antibodies to high-molecular-weight capsular polysaccharides. | The interaction between antipolysaccharide (anti-PS) antibodies and their antigens was investigated by the use of isothermal titration calorimetry to determine the thermodynamic binding constant (K), the change in the enthalpy of binding (DeltaH), and the binding density (N) to high-molecular-weight PSs. From these val... | 19,005,020 |
Modes and mishaps of neuronal migration in the mammalian brain. | The ability of neurons to migrate to their appropriate positions in the developing brain is critical to brain architecture and function. Recent research has elucidated different modes of neuronal migration and the involvement of a host of signaling factors in orchestrating the migration, as well as vulnerabilities of t... | 19,005,035 |
Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. | Ethanol alters the distribution and abundance of PKCdelta in neural cell lines. Here we investigated whether PKCdelta also regulates behavioral responses to ethanol. PKCdelta(-/-) mice showed reduced intoxication when administered ethanol and reduced ataxia when administered the nonselective GABA(A) receptor agonists p... | 19,005,054 |
Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. | Reactive oxygen species (ROS) modulate intracellular signaling but are also responsible for neuronal damage in pathological states. Microglia, the resident CNS macrophages, are prominent sources of ROS through expression of the phagocyte oxidase which catalytic subunit Nox2 generates superoxide ion (O2(.-)). Here we sh... | 19,005,069 |
Contributions of the human temporoparietal junction and MT/V5+ to the timing of interception revealed by transcranial magnetic stimulation. | To intercept a fast target at destination, hand movements must be centrally triggered ahead of target arrival to compensate for neuromechanical delays. The role of visual-motion cortical areas is unclear. They likely feed downstream parietofrontal networks with signals reflecting target motion, but do they also contrib... | 19,005,072 |
Evidence of dysregulated peripheral oxytocin release among depressed women. | Oxytocin is a hypothalamic neuropeptide that plays a key role in mammalian female reproductive function. Animal research indicates that central oxytocin facilitates adaptive social attachments and modulates stress and anxiety responses. Major depression is prevalent among postpubertal females, and is associated with pe... | 19,005,082 |
Differential response of gray poplar leaves and roots underpins stress adaptation during hypoxia. | The molecular and physiological responses of gray poplar (Populus x canescens) following root hypoxia were studied in roots and leaves using transcript and metabolite profiling. The results indicate that there were changes in metabolite levels in both organs, but changes in transcript abundance were restricted to the r... | 19,005,089 |
Primary prevention of violence against women: training needs of violence practitioners. | Practitioners in domestic violence and sexual assault programs have been encouraged by the National Center for Injury Prevention and Control to enhance their activities in violence prevention; however, many practitioners have not been trained in prevention concepts and strategies. Therefore, a needs assessment was unde... | 19,005,091 |
Asymptomatic unruptured intracranial aneurysms: approach to screening and treatment. | ABSTRACTOBJECTIVETo review the current knowledge of screening and treatment of asymptomatic unruptured intracranial aneurysms (AUIAs) using a case-based approach.SOURCES OF INFORMATIONPubMed was searched from January 1995 to January 2008 using the phrase unruptured intracranial aneurysm. Scientific statements of the St... | 19,005,121 |
Complementary and alternative medicine use among Chinese and white Canadians. | ABSTRACTOBJECTIVEThis study aimed to describe the level of complementary and alternative medicine (CAM) use and the factors associated with CAM use among Chinese and white Canadians.DESIGNA cross-sectional telephone survey conducted in English, Cantonese, and Mandarin.SETTINGCalgary, Alta.PARTICIPANTSChinese and white ... | 19,005,129 |
Effect of ThinPrep preparation on human papillomavirus detection and genotyping in rectal samples by PCR. | Specimen-to-specimen carryover during ThinPrep slide preparation was evaluated by comparing human papillomavirus genotypes detected prior and subsequent to the ThinPrep processing of 121 PreservCyt samples. Overall, 52 samples generated concordant genotypes and 38 had additional and 21 had fewer genotypes postprocessin... | 19,005,144 |
Coiled-coil-mediated dimerization is not required for myosin VI to stabilize actin during spermatid individualization in Drosophila melanogaster. | Myosin VI is a pointed-end-directed actin motor that is thought to function as both a transporter of cargoes and an anchor, capable of binding cellular components to actin for long periods. Dimerization via a predicted coiled coil was hypothesized to regulate activity and motor properties. However, the importance of th... | 19,005,209 |
A myopathy-linked desmin mutation perturbs striated muscle actin filament architecture. | Desmin interacts with nebulin establishing a direct link between the intermediate filament network and sarcomeres at the Z-discs. Here, we examined a desmin mutation, E245D, that is located within the coil IB (nebulin-binding) region of desmin and that has been reported to cause human cardiomyopathy and skeletal muscle... | 19,005,210 |
Modeling single and repeated dose pharmacokinetics of PFOA in mice. | Perfluorooctanoic acid (PFOA) displays complicated pharmacokinetics in that serum concentrations indicate long half-lives despite which steady state appears to be achieved rapidly. In this study, serum and tissue concentration time-courses were obtained for male and female CD1 mice after single, oral doses of 1 and 10 ... | 19,005,225 |
Nodular morphea. | Scleroderma may present as being strictly limited to the skin, as in morphea, or within a multiorgan disease, as in systemic sclerosis. Accordingly, cutaneous manifestations vary clinically. In nodular or keloidal scleroderma, patients develop lesions that are clinically indistinguishable from a keloid; however, the hi... | 19,005,241 |
Reasons for hospital admissions in dementia patients in Birmingham, UK, during 2002-2007. | There is a lack of evidence to explain why patients with dementia are admitted to a general hospital. Main reasons for hospitalisation were investigated in all patients admitted to a multi-ethnic general hospital during 2002-2007, by analysis of type of admission and primary diagnosis on admission. Anonymised data from... | 19,005,254 |
Change in morphology and oxytocin receptor expression in the uterine blood vessels during the involution process. | The histological changes in uterine blood vessels during pregnancy have been well investigated, but there have been few reports focusing on the changes in blood vessels during the involution process, especially within the first 24 h. We observed the process of uterine involution, focusing on the vessels of the resected... | 19,005,262 |
Patients presenting with AIDS in the HAART era: a collaborative cohort analysis. | Many patients infected with HIV still present with an AIDS diagnosis. The aim of this study was to evaluate the virological, immunological and clinical outcomes of HAART in these patients. The present study was a multi-cohort study. All patients with an AIDS diagnosis between 30 days before and 14 days after HIV diagno... | 19,005,269 |
Recurrent tuberculosis in HIV-infected patients in Rio de Janeiro, Brazil. | The risk of recurrent tuberculosis may increase in HIV-infected patients due to exogenous reinfection. We measured the frequency of and determined risk factors for recurrent tuberculosis in a cohort of HIV-infected patients in Rio de Janeiro, Brazil. Data were abstracted from medical records of HIV-infected patients at... | 19,005,276 |
The relationships between PON1 activity as well as oxLDL levels and coronary artery lesions in CHD patients with diabetes mellitus or impaired fasting glucose. | Lower paraoxonase (PON1) activity and higher oxidized low-density lipoprotein (oxLDL) levels are main risk factors of coronary heart disease (CHD). The aim of this study is to observe the characteristics of coronary artery lesions in CHD patients with or without hyperglycemia and relationships between coronary artery l... | 19,005,291 |
Cholesterol composition of erythrocyte membranes and its association with clinical presentation of coronary artery disease. | Presence of free cholesterol in atherosclerotic plaques is a major determinant of plaque instability. It is hypothesized that extravasated erythrocytes may contribute to free cholesterol accumulation in atherosclerotic plaques through their rich in cholesterol membrane. In this study we assessed whether cholesterol in ... | 19,005,293 |
Postinjury immune monitoring: can multiple organ failure be predicted? | Multiple organ failure is the main cause of late morbidity and mortality after severe injury. This disease state is driven by a dysfunctional immune system. Prediction of multiple organ failure on the basis of clinical parameters appears to be insufficient. A better understanding of immunological pathogenesis underlyin... | 19,005,307 |
The timing of spinal stabilization in polytrauma and in patients with spinal cord injury. | Despite improved care of multiple injured patients, controversial data about the best time point for decompression and stabilization of spine fractures and spinal cord injuries are published. Some studies even question the value of surgical management. In several mostly retrospective studies and a meta-analysis, there ... | 19,005,310 |
Return to physical activity after exertional rhabdomyolysis. | Exertional rhabdomyolysis (ER) is a condition characterized by muscle pain, swelling, and weakness following some exertional stress, with or without concomitant heat stress. Athletes who experience ER often present to the emergency department, the training room, or the physician's office seeking guidance and care for t... | 19,005,354 |
Surgical management and outcome of scalp subcutaneous granuloma annulare in children: case report. | Subcutaneous granuloma annulare (SGA) is a benign inflammatory disorder that rarely affects the scalp. We report 5 cases of children with SGA scalp lesions and discuss our clinical experience and the characteristic findings, diagnostic evaluation, method of treatment, and course of the disease. Five patients presented ... | 19,005,364 |
Barbiturate infusion for intractable intracranial hypertension and its effect on brain oxygenation. | Barbiturate-induced coma can be used in patients to treat intractable intracranial hypertension when other therapies, such as osmotic therapy and sedation, have failed. Despite control of intracranial pressure, cerebral infarction may still occur in some patients, and the effect of barbiturates on outcome remains uncer... | 19,005,378 |
Obesity and self-reported outcome after minimally invasive lumbar spinal fusion surgery. | Many patients undergoing lumbar spine fusion are overweight or obese. The relationship between body habitus and outcome after lumbar spine fusion surgery is not well defined. We analyzed a prospectively maintained database of self-reported pain and quality of life measures, including Visual Analog Scale pain score, Sho... | 19,005,386 |
Susceptibility of human mesenchymal stem cells to tacrolimus, mycophenolic acid, and rapamycin. | Mesenchymal stem cells (MSC) have multilineage differentiation and immunomodulatory capacities and are potentially useful for therapeutic applications, such as tissue regeneration and control of alloreactivity. MSC are present in most tissues including the transplantable organs. It is therefore unavoidable that MSC wil... | 19,005,411 |
Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule. | Using flow cytometry, fluorescent microscopy and examination of receptor glycosylation status, we demonstrate that an entire killer cell immunoglobulin-like receptor (KIR) locus (KIR2DS3)--assumed earlier to be surface expressed--appears to have little appreciable surface expression in transfected cells. This phenotype... | 19,005,473 |
Identifying genes for primary hypertension: methodological limitations and gene-environment interactions. | Hypertension segregates within families, indicating that genetic factors explain some of the variance in the risk of developing the disease; however, even with major advances in genotyping technologies facilitating the discovery of multiple genetic risk markers for cardiovascular and metabolic diseases, little progress... | 19,005,475 |
Telomere length is severely and similarly reduced in JAK2V617F-positive and -negative myeloproliferative neoplasms. | Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by chronic proliferation of hematopoietic progenitors. We studied the telomere length (TL) of 335 MPN patients and 93 gender- and age-matched controls using a quantitative PCR method (relative TL calculated as the ratio of the amount of te... | 19,005,480 |
The "caveolae brake hypothesis" and the epidermal barrier. | Epidermal permeability barrier formation depends upon lamellar body (LB) secretion/fusion with the apical plasma membrane (APM) of outermost stratum granulosum (SG) cell, creating cholesterol/glycosphingolipid-enriched lipid rafts-like domains. We found that the dimensions of these domains are comparable to lipid raft ... | 19,005,485 |
The role of microorganisms in coral bleaching. | Coral bleaching is the disruption of the symbiosis between the coral host and its endosymbiotic algae. The prevalence and severity of the disease have been correlated with high seawater temperature. During the last decade, the major hypothesis to explain coral bleaching is that high water temperatures cause irreversibl... | 19,005,495 |
Protists are microbes too: a perspective. | Our understanding of the composition and activities of microbial communities from diverse habitats on our planet has improved enormously during the past decade, spurred on largely by advances in molecular biology. Much of this research has focused on the bacteria, and to a lesser extent on the archaea and viruses, beca... | 19,005,497 |
Selective progressive response of soil microbial community to wild oat roots. | Roots moving through soil induce physical and chemical changes that differentiate rhizosphere from bulk soil, and the effects of these changes on soil microorganisms have long been a topic of interest. The use of a high-density 16S rRNA microarray (PhyloChip) for bacterial and archaeal community analysis has allowed de... | 19,005,498 |
Natural Killer Cell Receptor NKG2A/HLA-E Interaction Dependent Differential Thymopoiesis of Hematopoietic Progenitor Cells Influences the Outcome of HIV Infection. | HIV infection and its outcome is complex because there is great heterogeneity not only in clinical presentation, incomplete clinical information of markers of immunodeficiency and in measurements of viral loads. Also, there many gene variants that control not only viral replication but immune responses to the virus; it... | 19,005,583 |
Highly diastereo- and enantioselective construction of both central and axial chiralities by Rh-catalyzed [2 + 2 + 2] cycloaddition. | The cationic Rh-SEGPHOS complex catalyzed an intermolecular [2 + 2 + 2] cycloaddition of enynes, possessing an ortho-substituted aryl group on their alkyne terminus, with acetylenedicarboxylates. Bicyclic cyclohexa-1,3-dienes with both central and axial chiralities were obtained in extremely highly diastereo- and enant... | 19,005,587 |
Rhodium catalysed conjugate addition of a chiral alkenyltrifluoroborate salt: the enantioselective synthesis of hermitamides A and B. | The concise enantioselective synthesis of hermitamides A and B is presented utilising a rhodium catalysed conjugate addition reaction to introduce the side chain and chiral information in a single step via an alkenyltrifluoroborate salt. | 19,005,593 |
Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization. | N-Substituted pantothenamides are a class of pantothenic acid analogues which have been shown to act as inhibitors of coenzyme A biosynthesis and utilization, especially by blocking fatty acid metabolism through formation of inactive acyl carrier proteins. To fully explore the chemical diversity and inhibitory potentia... | 19,005,594 |
Presence of a meningioma in a cervical myelomeningocele sac. | An 11-year-old female, presented with a cervical myelomeningocele. Interestingly, the myelomeningocele sac was seen to contain a meningioma. There are no aetiological factors in the embryogenetic period that would lead to such a combination of lesions. In our opinion, the meningioma appeared in a later period because o... | 19,005,614 |
The self-thinning process in mangrove Kandelia obovata stands. | The self-thinning process was monitored in crowded Kandelia obovata Sheue, Liu & Yong stands over four years. The frequency distribution of tree phytomass was an L-shape, which was kept over the experimental period. Spearman's rank correlation coefficient for phytomass decreased as the time span of the comparison b... | 19,005,617 |
Oral cyclosporine A--the current picture of its liposomal and other delivery systems. | The discovery of cyclosporine A was a milestone in organ transplantation and the treatment of autoimmune diseases. However, developing an efficient oral delivery system for this drug is complicated by its poor biopharmaceutical characteristics (low solubility and permeability) and the need to carefully monitor its leve... | 19,005,620 |
Ladder-like amplification of the type I interferon gene cluster in the human osteosarcoma cell line MG63. | The organization of the type I interferon (IFN) gene cluster (9p21.3) was studied in a human osteosarcoma cell line (MG63). Array comparative genomic hybridization (aCGH) showed an amplification of approximately 6-fold which ended at both ends of the gene cluster with a deletion that extended throughout the 9p21.3 band... | 19,005,637 |
Frontal analysis microchip capillary electrophoresis to study the binding of ligands to receptors derivatized on magnetic beads. | The model binding of the glycopeptide antibiotic teicoplanin (Teic) from Actinoplanes teichomyceticus, immobilized on magnetic microspheres, to D-Ala-D-Ala terminus peptides was assessed using microchip capillary electrophoresis (MCE) with continuous frontal analysis (FA). Teic is closely related to vancomycin (Van), h... | 19,005,646 |
Surfactant-induced conformational transition of amyloid beta-peptide. | Accumulating evidence suggests that Abeta(1-42)-membrane interactions may play an important role in the pathogenesis of Alzheimer's disease. However, the mechanism of this structural transition remains unknown. In this work, we have shown that submicellar concentrations of sodium dodecyl sulfate (SDS) can provide a min... | 19,005,650 |
Chick embryo chorioallantoic membrane model systems to study and visualize human tumor cell metastasis. | Since their introduction almost a century ago, chick embryo model systems involving the technique of chorioallantoic grafting have proved invaluable in the in vivo studies of tumor development and angiogenesis and tumor cell dissemination. The ability of the chick embryo's chorioallantoic membrane (CAM) to efficiently ... | 19,005,674 |
Sudden unexpected death in an infant with L-2-hydroxyglutaric aciduria. | Inherited metabolic disorders are the cause of a small but significant number of sudden unexpected deaths in infancy. We report a girl who suddenly died at 11 months of age, during an intercurrent illness. Autopsy showed spongiform lesions in the subcortical white matter, in the basal ganglia, and in the dentate nuclei... | 19,005,678 |
Cystic fibrosis, aminoglycoside treatment and acute renal failure: the not so gentle micin. | Aminoglycosides have a wide spectrum of gram-negative anti-bacterial activities and are available at low cost, which makes them commonly used drugs, especially for patients with cystic fibrosis (CF), who often suffer from chronic lung infections from Pseudomonas aeruginosa. Unfortunately, this treatment seems to have r... | 19,005,685 |
Resolving discogenic pain. | Recent basic science studies on discogenic low back pain have provided new knowledge about this condition. This paper reviews some of these results and presents an overview of the following findings. The rat lumbar intervertebral disk may be innervated non-segmentally through the paravertebral sympathetic nerve and seg... | 19,005,695 |
A model for transcutaneous current stimulation: simulations and experiments. | Complex nerve models have been developed for describing the generation of action potentials in humans. Such nerve models have primarily been used to model implantable electrical stimulation systems, where the stimulation electrodes are close to the nerve (near-field). To address if these nerve models can also be used t... | 19,005,714 |
Polymorphisms of Saccharomyces cerevisiae genes involved in wine production. | The setting up of new molecular methods for Saccharomyces cerevisiae typing is valuable in enology. Actually, the ability to discriminate different strains in wine making can have a benefit both for the control of the fermentation process and for the preservation of wine typicity. This study focused on the screening of... | 19,005,725 |
Argon plasma coagulation and gastric bypass--a novel solution to stomal dilation. | A patulous gastro-enterostomy after gastric bypass is a common cause of poor restriction and poor weight loss. Revisional surgery is an option but may be hazardous. This case report highlights the use of argon plasma coagulation by flexible endoscopy to reduce stomal size, improve restriction, and avoid revisional surg... | 19,005,735 |
Novel role of toll-like receptor 3, RIG-I and MDA5 in poly (I:C) RNA-induced mesothelial inflammation. | Viral inflammation and infection of mesothelial cells (MC) are a major problem in several organ systems including pleura, pericardium and peritoneum. Toll-like receptors (TLRs) are an essential part of the innate immune system for early recognition of pathogen-associated molecular patterns. TLRs recognise molecular pat... | 19,005,739 |
Cloning, characterization and localization of CHS gene from blood orange, Citrus sinensis (L.) Osbeck cv. Ruby. | Chalcone synthase (CHS) is involved in the biosynthesis of anthocyanin. In this study, a full-length DNA of CHS gene (named as CsCHS-bo) was cloned from the blood orange, Citrus sinensis (L.) Osbeck cv. Ruby. The gene was 1,512 bp in size containing an open reading frame (1,176 bp) encoding 391 amino acids. Comparative... | 19,005,777 |
Material suppliers and industrial metabolism. | Life Cycle Assessment (LCA) is not sufficiently tailored to the analysis of strategic environmental problems of material suppliers. Sustainable development calls for a reduction by a factor of 10 to 20 in the material intensity of the economy, a situation which leads to dramatic shifts in markets for raw materials. Fur... | 19,005,794 |
Microbial phenol degradation of organic compounds in natural systems: Temperature-inhibition relationships. | The combined influence of high phenol concentrations and low temperatures on aerobic and anaerobic phenol degradation kinetics was investigated in microbial enrichment cultures to evaluate temperature-inhibition relationships with respect to the ambient conditions in polluted habitats. The inhibition of microbial pheno... | 19,005,802 |
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