title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Intracellular chemical imaging of the developmental phases of human neuromelanin using synchrotron X-ray microspectroscopy. | The microchemical environment of neuromelanin (NM) in whole neurons from formalin fixed and paraffin embedded human substantia nigra sections were characterized using synchrotron chemical X-ray microscopy. Concentrations of NM-associated elements increased in the developing brain; the highest levels of most elements we... | 19,007,186 |
C-H bond activation of heteroarenes mediated by a half-sandwich iron complex of N-heterocyclic carbene. | Half-sandwich iron complexes of N-heterocyclic carbenes, Cp*Fe(L(R))Cl (2a; L(Mes) = 1,3-dimesityl-imidazol-2-ylidene, 2b; L(iPr) = 1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene, Cp* = eta(5)-C5Me5), have been synthesized by the reaction of Cp*Fe{N(SiMe3)2} (1) with the corresponding imidazolium salts. Treatment of 2a... | 19,007,215 |
A tunable photosensor. | A pyrene-modified beta-cyclodextrin (pyrenecyclodextrin)-decorated single-walled carbon nanotube (SWNT) field-effect transistor (FET) device was fabricated, which can serve as a tunable photosensor to sense a fluorescent adamantyl-modified Ru complex (ADA-Ru). When the light is on (I = 40 W m(-2) and lambda = 280 nm), ... | 19,007,219 |
Intestinal and peripheral immune response to MON810 maize ingestion in weaning and old mice. | This study evaluated the gut and peripheral immune response to genetically modified (GM) maize in mice in vulnerable conditions. Weaning and old mice were fed a diet containing MON810 or its parental control maize or a pellet diet containing a GM-free maize for 30 and 90 days. The immunophenotype of intestinal intraepi... | 19,007,233 |
Total synthesis of (-)-2-epi-peloruside A. | A convergent synthesis of (-)-2-epi-peloruside A has been achieved. Highlights include implementation of multicomponent type I anion relay chemistry (ARC) to unite 2-TBS-1,3-dithiane with two epoxides to construct the eastern hemisphere, a late-stage dithiane union to secure the complete, fully functionalized carbon ba... | 19,007,239 |
Self-assembly of nanodonut structure from a cone-shaped designer lipid-like peptide surfactant. | We report here the donut-shaped nanostructure formation from the self-assembly of a designer lipid-like amphiphilic cone-shaped peptide. The critical aggregation concentration was measured using dynamic light scattering in water and phosphate-buffered saline. The dynamic self-assembly of the peptide was also studied us... | 19,007,256 |
Protease-specific nanosensors for magnetic resonance imaging. | Imaging of enzyme activity is a central goal of molecular imaging. With the introduction of fluorescent smart probes, optical imaging has become the modality of choice for experimental in vivo detection of enzyme activity. Here, we present a novel high-relaxivity nanosensor that is suitable for in vivo imaging of prote... | 19,007,261 |
Designing temperature-responsive biocompatible copolymers and hydrogels based on 2-hydroxyethyl(meth)acrylates. | Free-radical copolymerization of 2-hydroxyethyl methacrylate with 2-hydroxyethyl acrylate can be successively utilized for the synthesis of water-soluble polymers and hydrogels with excellent physicochemical properties, thus showing promise for pharmaceutical and biomedical applications. In the work presented it has be... | 19,007,281 |
Isoflavonoid glycosides from the roots of Baphia bancoensis. | Chemical investigation of the methanol extract of the roots of Baphia bancoensis led to the isolation and characterization of three new isoflavonoid glycosides (1-3). Their structures were determined on the basis of spectroscopic studies andchemical evidence. Antibacterial activity of isolated compounds was evaluated a... | 19,007,285 |
Antileishmanial constituents of the Panamanian endophytic fungus Edenia sp. | Bioassay-directed fractionation of extracts from the fermentation broth and mycelium of the fungus Edenia sp. led tothe isolation of five antileishmanial compounds, preussomerin EG1 (1), palmarumycin CP2 (2), palmarumycin CP17 (3), palmarumycin CP18 (4), and CJ-12,371 (5). Compounds 3 and 4 are new natural products, an... | 19,007,286 |
Gross placental structure in a low-risk population of singleton, term, first-born infants. | Suboptimal fetal growth has been associated with an increased risk of adult disease, which may be exacerbated by an increased placental weight-to-fetal weight ratio. Placental weight is a summary measure of placental growth and development throughout pregnancy. However, measures of placental structure, including the ch... | 19,007,303 |
Current and emerging paradigms in the therapeutic management of atherosclerosis. | The pathogenesis of atherosclerosis lies in abnormalities in lipoprotein metabolism leading to pathological interactions with vessel walls and the release of inflammatory components, which further aggravate the disease condition. To elucidate current and emerging trends in drug discovery towards the development of new ... | 19,007,321 |
Mast cells in health and disease: from basic science to clinical application 4-5 July 2008, Stuttgart, Germany. | In July 2008, the fifth and last meeting of the Mast Cells and Chronic Inflammatory Diseases (MCCID) network was hosted by Axel Lorentz and Stephan Bischoff at the University of Hohenheim, in the Aula of the Chateau Hohenheim, Stuttgart. The MCCID initiative is a Marie Curie early stage research training (EST)-sponsore... | 19,007,326 |
A-overhang-dependent repeat expansion determination (ADRED). | In this study we present a quick and easy method for counting trinucleotide repeats by de-oxyadenosine overhang (A-overhang)-dependent repeat expansion determination (ADRED). During standard Taq DNA polymerase-based sequencing reactions, the unterminated sequencing products of short PCR fragments are tagged with a 3'-e... | 19,007,342 |
Ovarian structure in mice lines selected for weight. | Selection for body weight at 49 day of age (s and h, downward selected lines; s' and h', upward selected lines) affected reproductive traits in CF1 mice lines. The objective of this study was to compare ovarian structures in females of these lines, as well as in unselected controls (Line t). The number of ovarian folli... | 19,007,351 |
Gross anatomy of the female genital organs of the domestic donkey (Equus asinus Linné, 1758). | Although donkeys play an important role as companion or pack and draught animals, theriogenological studies and anatomical data on the genital organs of the jenny are sparse. To provide anatomical descriptions and morphometric data, the organa genitalia feminina, their arteries and the ligamentum latum uteri of 10 adul... | 19,007,353 |
Paclitaxel incorporated in hydrophobically derivatized hyperbranched polyglycerols for intravesical bladder cancer therapy. | To develop paclitaxel incorporated into unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols (dHPGs) for use as mucoadhesive intravesical agents against non-muscle-invasive bladder cancer. Two different types of dHPGs (HPG- C10-polyethylene glycol (PEG) and polyethyleneimine (PEI)-C18-... | 19,007,363 |
Is the body mass index a predictor of adverse outcome in prostate cancer after radical prostatectomy in a mid-European study population? | To evaluate the effect of body mass index (BMI) on the histopathological and clinical outcome in prostate cancer. In a prospective urological cancer database, 620 patients with prostate cancer had a radical prostatectomy (RP) as a curative treatment. The patients were categorized into three groups of BMI (kg/m(2)); <... | 19,007,372 |
Research on rural veterans: an analysis of the literature. | The Veterans Health Administration (VA) provides comprehensive health care services to veterans across the United States. Recently, the VA established an Office of Rural Health to address the health care needs of rural veterans. To review the literature on rural veterans' health care needs in order to identify areas fo... | 19,007,387 |
A contract-based training system for rural physicians: follow-up of Jichi Medical University graduates (1978-2006). | The number of studies on long-term effects of rural medical education programs is limited. Personal factors that are associated with long-term retention of physicians in rural areas are scarcely known. The authors studied the outcomes of Jichi Medical University (JMU), whose mission is to produce rural doctors, and ana... | 19,007,390 |
Aspergillus nidulans FlbE is an upstream developmental activator of conidiation functionally associated with the putative transcription factor FlbB. | Aspergillus nidulans switches from vegetative growth to conidiation when aerial hyphae make contact with the atmosphere, or are subjected to specific environmental stress. The activation of the central conidiation pathway led by the transcription factor brlA is a critical milestone in this morphogenetic transition. A n... | 19,007,409 |
Of blood, brains and bacteria, the Amt/Rh transporter family: emerging role of Amt as a unique microbial sensor. | Members of the Amt/Rh family of transporters are found almost ubiquitously in all forms of life. However, the molecular state of the substrate (NH(3) or NH(4)(+)) has been the subject of active debate. At least for bacterial Amt proteins, the model emerging from computational, X-ray crystal and mutational analysis is t... | 19,007,411 |
Loss of Hda activity stimulates replication initiation from I-box, but not R4 mutant origins in Escherichia coli. | Initiation of chromosome replication in Escherichia coli is limited by the initiator protein DnaA associated with ATP. Within the replication origin, binding sites for DnaA associated with ATP or ADP (R boxes) and the DnaA(ATP) specific sites (I-boxes, tau-boxes and 6-mer sites) are found. We analysed chromosome replic... | 19,007,419 |
Repression of galP, the galactose transporter in Escherichia coli, requires the specific regulator of N-acetylglucosamine metabolism. | Soupene et al. [J. Bacteriol. (2003) 185 5611-5626] made the unexpected observation that the presence of a mutation, in the gene for the N-acetylglucosamine repressor, nagC, increased the growth rate of Escherichia coli MG1655 on galactose, an unrelated sugar. We have found that NagC, binds to a single, high-affinity s... | 19,007,420 |
Targeting the UPS as therapy in multiple myeloma. | The coordinated regulation of cellular protein synthesis and degradation is essential for normal cellular functioning. The ubiquitin proteasome system mediates the intracellular protein degradation that is required for normal cellular homeostasis. The 26S proteasome is a multi-enzyme protease that degrades redundant pr... | 19,007,431 |
Two-dimensional imaging of water vapor by near-infrared laser absorption spectroscopy. | Both a flow of water vapor generated from a humidification device and stable water vapor at constant moisture were successfully visualized by near-infrared (NIR) laser absorption spectroscopy. Two different types of optical arrangement for two-dimensional (2D) imaging, i.e., one-wavelength reflection and two-wavelength... | 19,007,462 |
Spectroscopic properties of some derivatives of polycyclic aromatic hydrocarbons. | The aim of this paper is to provide a general picture of the spectral characteristics of some polycyclic aromatic hydrocarbon (PAH) derivatives. A great deal of data concerning PAHs has been reported in the literature, but there is lack of comprehensiveness about important parameters in the same experimental conditions... | 19,007,465 |
Spectroscopic study on the enhanced excitation of an electron cyclotron resonance nitrogen plasma by pulsed laser ablation of an aluminum target. | The influence of pulsed laser ablation of an aluminum target on the nitrogen plasma produced by electron cyclotron resonance (ECR) microwave discharge has been studied by optical emission spectroscopy (OES) with time and space resolution. The continuous wave (CW) feature of the optical emissions from the ECR nitrogen p... | 19,007,469 |
Preparation and chiral recognition of a mono[6A-N-1-(2-hydroxy)-phenylethylimino-6A-deoxy]-beta-cyclodextrin HPLC stationary phase. | A novel chiral stationary phase (CSP) is obtained by linking the beta-CD to a chiral block (commercially available phenylglycinol) by rigid C=N bond. This chiral stationary phase exhibites good enantioselectivity for several alkylaromatic alcohols and a variety of ferrocene derivatives under reversed-phase conditions, ... | 19,007,478 |
The chiral separation of triazole pesticides enantiomers by amylose-tris (3,5-dimethylphenylcarbamate) chiral stationary phase. | The amylose-tris(3,5-dimethylphenylcarbamate) chiral stationary phase was synthesized and used to separate the enantiomers of triazole pesticides by high-performance liquid chromatography. The mobile phase was n-hexane-isopropanol applying a flow rate of 1.0 mL/min. Six triazole pesticides were enantioselectively separ... | 19,007,480 |
Quantitative determination of atorvastatin and para-hydroxy atorvastatin in human plasma by LC-MS-MS. | A specific, sensitive, and fast method based on high-performance liquid chromatography coupled to tandem mass spectrometry was developed for the determination of atorvastatin and para-hydroxy atorvastatin in human plasma. Solid-phase extraction was used to isolate the compounds from human plasma followed by injection o... | 19,007,492 |
Simultaneous determination of theobromine, (+)-catechin, caffeine, and (-)-epicatechin in standard reference material baking chocolate 2384, cocoa, cocoa beans, and cocoa butter. | A reverse-phase liquid chromatography analysis is used to access the quantity of theobromine, (+)-catechin, caffeine, and (-)-epicatechin in Standard Reference Material 2384 Baking Chocolate, cocoa, cocoa beans, and cocoa butter using water or a portion of the mobile phase as the extract. The procedure requires minimal... | 19,007,497 |
Urinary elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in cannabis users during continuously monitored abstinence. | The time course of 11-nor-9-carboxy-Delta9-tetrahydrocannnabinol (THCCOOH) elimination in urine was characterized in 60 cannabis users during 24 h monitored abstinence on a closed research unit for up to 30 days. Six thousand, one hundred fifty-eight individual urine specimens were screened by immunoassay with values &... | 19,007,504 |
Quantitation of benzodiazepines in whole blood by electron impact-gas chromatography-mass spectrometry. | Benzodiazepines are frequently encountered in forensic toxicology. A literature search was conducted to find a simple method using electron impact-gas chromatography-mass spectrometry (EI-GC-MS) to examine whole blood specimens for the most commonly encountered benzodiazepines in the United States. A recently published... | 19,007,516 |
Free oxycodone concentrations in 67 postmortem cases from the Hennepin County medical examiner's office. | Heart blood free oxycodone concentrations in oxycodone-related and mixed drug overdose deaths were compared with those found incidentally at autopsy in medical examiner cases. Between 2000 and 2005, 67 oxycodone-positive postmortem cases were identified. Thirty of 67 cases (44.8%) were determined to be drug overdoses. ... | 19,007,520 |
Virus-induced vasculitis. | There is a growing understanding of the different syndromes that have a definite, and in some cases a possible, association with viral infections. Hepatitis C virus-associated mixed cryoglobulinemias and hepatitis B virus-associated polyarteritis nodosa are examples of a vasculitis with a definite viral association. Ho... | 19,007,534 |
Effectiveness of transcutaneous electrical nerve stimulation for treatment of hyperalgesia and pain. | Transcutaneous electrical nerve stimulation (TENS) is a nonpharmacologic treatment for pain relief. TENS has been used to treat a variety of painful conditions. This review updates the basic and clinical science regarding the use of TENS that has been published in the past 3 years (ie, 2005-2008). Basic science studies... | 19,007,541 |
Influencing population health performance: feedback from managers, population health staff and clinicians on the NSW Population Health Standards for Area Health Services. | The NSW Population Health Standards for Area Health Services have recently been introduced in NSW to assist area health services assess and improve performance in population health. Greater Western Area Health Service was the pilot site for trialling the Standards as a self-assessment tool. Following self-assessment, m... | 19,007,542 |
Oestradiol-induced spermatogenesis requires a functional androgen receptor. | Spermatogenesis requires androgen but, paradoxically, oestradiol (E2) treatment stimulates spermatogenic development in gonadotrophin- and androgen-deficient hypogonadal (hpg) mice. The mechanisms of E2-induced spermatogenesis were investigated by determining intratesticular E2 levels and testis cell populations in E2-... | 19,007,549 |
Admission to hospital for effects of heat and light: NSW, 1993-94 to 2003-04. | The study examined the hospital admission rates and characteristics of patients experiencing severe heat-related morbidity in NSW using data from the NSW Health Inpatient Statistics Collection. The study covered the 11-year period from July 1993 to June 2004. ICD-10-AM. codes examined included T67 (effects of heat and ... | 19,007,545 |
[Necrotic lipoma of the posterior mediastinum]. | Lipomas are well-differentiated, encapsulated masses composed of adipocytes. Intrathoracic lipomas are rare, but found most commonly in the pleura or anterior mediastinum. Computed tomography shows fatty, homogenous content of the mass and will establish the diagnosis. Areas with a higher fat density are suggestive of ... | 19,007,571 |
[Analysis of mortality in myocardial infarction patients treated with primary angioplasty]. | Primary angioplasty is an effective method to achieve myocardial reperfusion in ST-elevated myocardial infarction (MI). The objective of this study was to determine the independent factors that could predict mortality in MI patients treated with primary angioplasty and to analyze the prognostic value of tissue reperfus... | 19,007,575 |
Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping. | The purpose of this study was to investigate a noninvasive method for quantifying diffuse myocardial fibrosis with cardiac magnetic resonance imaging (CMRI). Diffuse myocardial fibrosis is a fundamental process in pathologic remodeling in cardiomyopathy and is postulated to cause increased cardiac stiffness and poor cl... | 19,007,595 |
The role of assisted hatching in in vitro fertilization: a review of the literature. A Committee opinion. | This Committee Opinion reviews the published literature regarding appropriate usage of assisted hatching as a part of in vitro fertilization. | 19,007,629 |
Salpingectomy for hydrosalpinx prior to in vitro fertilization. | Salpingectomy for hydrosalpinges before in vitro fertilization increases the success rate. | 19,007,649 |
Androgen deficiency in the aging male. | The purpose of this Educational Bulletin is to review current methods of evaluation, the indications for treatment, and to provide recommendations for treatment of androgen deficiency in the aging male (ADAM). | 19,007,654 |
Chapter 4. Using the zebrafish to study vessel formation. | Danio rerio, commonly referred to as the zebrafish, is a powerful animal model for studying the formation of the vasculature. Zebrafish offer unique opportunities for in vivo analysis of blood and lymphatic vessels formation because of their accessibility to large-scale genetic and experimental analysis as well as the ... | 19,007,661 |
Chapter 12. Structure of microvascular networks in genetic hypertension. | Microvascular rarefaction, defined by a loss of terminal arterioles, small venules, and/or capillaries, is a common characteristic of the hypertension syndrome. While rarefaction has been associated with vessel-specific free radical production, deficient leukocyte adhesion, and cellular apoptosis, the relationships of ... | 19,007,669 |
Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. | This article reviews the pathophysiology of non-thyroidal illness syndrome (NTIS) and euthyroid sick syndrome (ESS), a multifactorial phenomenon characterized by suppression of thyroid hormone levels that has been described in several disease states, probably due to different causes in different patients. It also descr... | 19,007,679 |
Thyroid hormone regulation of perinatal cardiovascular function. | Thyroid hormone plays an important role in regulating cardiovascular function during the transition to extrauterine physiology. Multiple mechanisms participate, ranging from transcriptional to more immediate nongenomic modes of regulation. | 19,007,680 |
Progression of peripheral arterial disease predicts cardiovascular disease morbidity and mortality. | The purpose of this study was to examine the association of progressive versus stable peripheral arterial disease (PAD) with the risk of future cardiovascular disease (CVD) events. An independent association between PAD, defined by low values of the ankle-brachial index (ABI), and future CVD risk has been demonstrated.... | 19,007,695 |
A collaborative curricular model for implementing evidence-based nursing in a critical care setting. | This article discusses how a curricular model for introducing nurses to the Registered Nurses' Association of Ontario Best Practice Guideline Risk Assessment and Prevention of Pressure Ulcers was used to reduce pressure ulcer prevalence in the critical care setting. This curricular model is particularly relevant to hos... | 19,007,708 |
Working in an eICU unit: life in the box. | This ethnographic study of the VISICU eICU (VSISCU, Inc., Baltimore, MD) work environment in a large midwestern health care system describes everyday life working in a telemedicine intensive care. Data were gathered through 60 hours of observation and formal interviews of eICU clinician team members. Working in the rem... | 19,007,710 |
Simulation as a vehicle for enhancing collaborative practice models. | Clinical simulation used in a collaborative practice approach is a powerful tool to prepare health care providers for shared responsibility for patient care. Clinical simulations are being used increasingly in professional curricula to prepare providers for quality practice. Little is known, however, about how these si... | 19,007,713 |
Specific IgA and IgG antibodies in paired serum and breast milk samples in human strongyloidiasis. | Strongyloidiasis, caused by the nematode Strongyloides stercoralis, is one of the major worldwide parasitic infections in humans. Breastfeeding may offer a potential protection against this infection. Feces, serum and milk samples were obtained from 90 lactating women from Clinical Hospital of Universidade Federal de U... | 19,007,741 |
Activation of hindbrain neurons in response to gastrointestinal lipid is attenuated by high fat, high energy diets in mice prone to diet-induced obesity. | Food intake is controlled by peripheral signals from the gastrointestinal tract and adipocytes, which are integrated within the central nervous system. There is evidence that signals from the GI tract are modulated by long term changes in diet, possibly leading to hyperphagia and increased body weight. We tested the hy... | 19,007,755 |
Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. | The Rho family of small GTPases has been implicated in many neurological disorders including mental retardation, but whether they are involved in primary microcephaly (microcephalia vera) is unknown. Here, we examine the role of Rac1 in mammalian neural progenitors and forebrain development by a conditional gene-target... | 19,007,770 |
Influence of terminal nerve branch size on motor neuron regeneration accuracy. | A necessary prerequisite for recovery of motor function following a peripheral nerve injury is the correct choice by regenerating motor neurons to reinnervate the original distal nerve branch to denervated muscle. The present studies use the mouse femoral nerve as a model system to examine factors that influence such m... | 19,007,776 |
Perfusion fixation preserves enhanced yellow fluorescent protein and other cellular markers in lymphoid tissues. | Fluorescent proteins are increasingly being used to analyze cellular gene expression and to facilitate tracking of cell lineages in vivo. One of these, enhanced yellow fluorescent protein (EYFP) has several properties such as intense fluorescence and little to no toxicity in cells, which makes it an excellent molecule ... | 19,007,785 |
Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes. | Exposure to high levels of glucose induces the production of reactive oxygen species (ROS) in cardiomyocytes that may contribute to the development of cardiomyopathy in diabetes. Nuclear factor erythroid 2-related factor 2 (Nrf2) controls the antioxidant response element (ARE)-dependent gene regulation in response to o... | 19,007,787 |
Complex patterns of histidine, hydroxylated amino acids and the GxxxG motif mediate high-affinity transmembrane domain interactions. | Specific interactions of transmembrane helices play a pivotal role in the folding and oligomerization of integral membrane proteins. The helix-helix interfaces frequently depend on specific amino acid patterns. In this study, a heptad repeat pattern was randomized with all naturally occurring amino acids to uncover nov... | 19,007,788 |
Ribosomal intersubunit bridge B2a is involved in factor-dependent translation initiation and translational processivity. | Intersubunit bridges are important for holding together subunits in the 70S ribosome. Moreover, a number of intersubunit bridges have a role in modulating the activity of the ribosome during translation. Ribosomal intersubunit bridge B2a is formed by the interaction between the conserved 23S rRNA helix-loop 69 (H69) an... | 19,007,789 |
Differential antimicrobial peptide gene expression patterns during early chicken embryological development. | The adaptive immune system is not completely developed when chickens hatch, so the innate immune system has evolved a range of mechanisms to deal with early pathogenic assault. Avian beta-defensins (AvBDs) and cathelicidins (CTHLs) are two major sub-classes of antimicrobial peptides (AMPs) with a fundamental role in bo... | 19,007,808 |
Time-dependent segmentation of BrdU-signal leads to late detection problems in studies using BrdU as cell label or proliferation marker. | Bromodeoxyuridine incorporates into DNA during mitosis. A long-term stability of the incorporated BrdU is important for the recovery of BrdU-labeled cells. For testing the stability of BrdU incorporation into DNA we pulse-labeled mesenchymal stem cells with BrdU and observed these cells in vitro over 4 weeks. During th... | 19,007,815 |
Chimeric virus-like particles for the delivery of an inserted conserved influenza A-specific CTL epitope. | The small hepatitis B virus surface antigens (HBsAg-S) have the ability to self-assemble with host-derived lipids into empty non-infectious virus-like particles (VLPs). HBsAg-S VLPs are the sole component of the licensed hepatitis B vaccine, and they are a useful delivery platform for foreign epitopes. To develop VLPs ... | 19,007,818 |
Identification of nose-to-brain homing peptide through phage display. | Brain delivery of drug molecules through the nasal passage represents a viable approach for bypassing the blood-brain barrier (BBB) but remains a major challenge due to lack of efficient homing carriers. To screen for potential peptides with the ability to transport into the brain via the nasal passage, we applied a C7... | 19,007,831 |
Immunogenicity and safety of measles-mumps-rubella-varicella (MMRV) vaccine followed by one dose of varicella vaccine in children aged 15 months-2 years or 2-6 years primed with measles-mumps-rubella (MMR) vaccine. | In this open, randomized, comparative study (105908/NCT00353288), 458 age-stratified children (15 months-2 years and 2-6 years) previously primed with MMR received one dose of either a combined MMRV vaccine (Priorix-Tetra, MMRV group) or concomitant MMR and varicella vaccines (Priorix and Varilrix, MMR+V group), follow... | 19,007,835 |
Insights into the role of genetic alterations in adrenocortical tumorigenesis. | Whereas benign adrenocortical tumors are frequent in the population, adrenocortical carcinoma (ACC) is a rare cancer. Significant advances in the understanding of the pathogenesis of sporadic ACCs have been possible through the study of hereditary syndromes responsible for ACCs. The genetic alterations involved in thes... | 19,007,854 |
Characterization and monitoring of pseudo-polymorphs in manufacturing process by NIR. | Moisture-sensitive pseudo-polymorphs with different stabilities were characterized, and their polymorphisms were monitored in the process of tableting and film coating by near-infrared (NIR) spectroscopy. In this study, we proved that we could successfully maintain the crystal form ratio in the tablet by controlling th... | 19,007,870 |
Self-assembled drug delivery systems: Part 3. In vitro/in vivo studies of the self-assembled nanoparticulates of cholesteryl acyl didanosine. | Self-assembled drug delivery systems (SADDS) are defined as the self-assemblies of amphiphilic prodrugs, integrating prodrugs, molecular self-assembly and nanotechnology for drug targeting and controlled release. Cholesteryl-succinyl didanosine (CSD) and cholesteryl-adipoyl didanosine (CAD) nanoparticulate systems in w... | 19,007,871 |
Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity. | Microglia play a prominent role in the brain's inflammatory response to injury or infection by migrating to affected locations, secreting inflammatory molecules, and phagocytosing damaged tissue. However, because severe or chronic neuroinflammation exacerbates many neurological conditions, controlling microglia actions... | 19,007,880 |
The C1 and C2 domains target human type 6 adenylyl cyclase to lipid rafts and caveolae. | Previous data has shown that adenylyl cyclase type 6 (AC6) is expressed principally in lipid rafts or caveolae of cardiac myocytes and other cell types while certain other isoforms of AC are excluded from these microdomains. The mechanism by which AC6 is localized to lipid rafts or caveolae is unknown. In this study, w... | 19,007,881 |
Sensory gating and source analysis of the auditory P50 in low and high suppressors. | Impairments in sensory gating in schizophrenia have been reflected by diminished suppression of the scalp-recorded middle latency auditory P50 event-related potential (MLAERP) elicited by the second (S(2)) of a pair (S(1)-S(2)) of clicks. As understanding the functional neural substrates of aberrant gating would have i... | 19,007,892 |
Preliminary analysis of miRNA pathway in Schistosoma mansoni. | RNA silencing refers to a series of nuclear and cytoplasmatic processes involved in the post-transcriptional regulation of gene expression or post-transcriptional gene silencing (PTGS), either by sequence-specific mRNA degradation or by translational arrest. The best characterized small RNAs are microRNAs (miRNAs), whi... | 19,007,911 |
Towards a cognitive model of distraction by auditory novelty: the role of involuntary attention capture and semantic processing. | Unexpected auditory stimuli are potent distractors, able to break through selective attention and disrupt performance in an unrelated visual task. This study examined the processing fate of novel sounds by examining the extent to which their semantic content is analyzed and whether the outcome of this processing can im... | 19,007,926 |
Anterior cruciate ligament injury induced by internal tibial torsion or tibiofemoral compression. | The knee is one of the most frequently injured joints in the human body. Approximately 91% of ACL injuries occur during sporting activities, usually from a non-contact event. The most common kinetic scenarios related with ACL injuries are internal twisting of the tibia relative to the femur or combined torque and compr... | 19,007,932 |
Large-scale cold water dispersant effectiveness experiments with Alaskan crude oils and Corexit 9500 and 9527 dispersants. | There continues to be reluctance in some jurisdictions to use chemical dispersants as a viable countermeasure for accidental oil spills. One argument used by some opponents to dispersant use is that "chemical dispersants do not work effectively in cold water". To address this issue, the U.S. Minerals Management Service... | 19,007,943 |
Proteomic identification of differentially-expressed proteins in squamous cervical cancer. | To identify candidate biomarkers for squamous cervical cancer as well as reveal the molecular mechanism underlying this disease by a proteomic approach. Proteins from 10 pairs of human squamous cervical cancer and matching adjacent normal cervical tissues were separated by two-dimensional gel electrophoresis and the di... | 19,007,971 |
Identification of O-glycosylated decapeptides within the MUC1 repeat domain as potential MHC class I (A2) binding epitopes. | The MUC1 glycoprotein is considered a tumor antigen due to its over expression and aberrant glycosylation in cancer tissues. The latter results in appearance of new antigenic tumor specific glycopeptides not found on normal glycoforms of the mucin. MUC1 glycopeptides can be presented by APCs on MHC class II molecules t... | 19,007,994 |
Paracrine effects of CD34 progenitor cells on angiogenic endothelial sprouting. | Progenitor cells contribute to repair of ischemia-associated disturbances of microcirculations, but detailed mechanisms of paracrine angiogenic activation of endothelium by progenitor cells are unclear. The present study was designed to test whether progenitor cells maintain their activation pattern of cytokine secreti... | 19,008,002 |
The uneven geographies of transnational advocacy: the case of the Talo Dam. | The Talo Dam was built in 2006 on the Bani River, a tributary of the Niger River in Mali. The path towards the completion of the project has been complex and controversial. This paper offers a case-study of the advocacy efforts initially opposed to, and later in support of the building of the Talo Dam. Several internat... | 19,008,033 |
CXCR4 mediates the proliferation of glioblastoma progenitor cells. | Increasing evidence points to a fundamental role for cancer stem cells (CSC) in the initiation and propagation of many tumors. As such, in the context of glioblastoma multiforme (GBM), the development of treatment strategies specifically targeted towards CSC-like populations may hold significant therapeutic promise. To... | 19,008,040 |
Perceived peer delinquency and the genetic predisposition for substance dependence vulnerability. | Like many behavioral phenotypes, generalized vulnerability to substance dependence in adolescence has a complex etiology; it is influenced by both genetic and environmental risks, with a heritability of approximately 0.40 [Button, T.M., Hewitt, J.K., Rhee, S.H., Young, S.E., Corley, R.P., Stallings, M.C., 2006. Examina... | 19,008,053 |
Correlation between CT patterns and pathological classification of intraductal papillary mucinous neoplasm. | To examine CT patterns of intraductal papillary mucinous neoplasm (IPMN), analyze their correlation with pathologic classification, and discuss the value of CT in the diagnosis and differential diagnosis of IPMN. CT patterns of 39 IPMN patients, whose clinical data were complete and whose diagnosis was confirmed by sur... | 19,008,065 |
Research on the diffusion of evidence-based treatments within substance abuse treatment: a systematic review. | This article provides a comprehensive review of research studies that have examined the diffusion of evidence-based treatments (EBTs) within the field of substance abuse treatment. Sixty-five research studies were identified and were grouped into one of three major classifications: attitudes toward EBTs, adoption of EB... | 19,008,068 |
[A survey of neuromuscular relaxant use from anaesthesiology residents in training]. | There is need to assess our practice of neuromuscular monitoring according to national consensus guidelines. The aim of this study was to evaluate practice adherence to guidelines in teaching hospitals. A questionnaire designed to provide information concerning the use of muscle relaxant for tracheal intubation and sur... | 19,008,070 |
Patients were more consistent in randomized trial at prioritizing childbirth preferences using graphic-numeric than verbal formats. | We developed an evidence-based decision aid to help women with a prior cesarean to prioritize their childbirth preferences related to a future birth. Because there was uncertainty about which scale format would assist the patients in being most consistent in prioritizing preferences in a multiattribute decision model, ... | 19,008,073 |
Mesenchymal stem cell differentiation on microstructured poly (methyl methacrylate) substrates. | Recent studies on 2D substrates have revealed the importance of surface properties in affecting cell behaviour. In particular, surface topography appears to influence and direct cell migration. The development of new technologies of hot embossing and micro-imprinting has made it possible to study cell interactions with... | 19,008,086 |
Development of lightweight aggregate from dry sewage sludge and coal ash. | In this study, dry sewage sludge (DSS) as the principal material was blended with coal ash (CA) to produce lightweight aggregate. The effects of different raw material compositions and sintering temperatures on the aggregate properties were then evaluated. In addition, an environmental assessment of the lightweight agg... | 19,008,090 |
Lipid II: a central component in bacterial cell wall synthesis and a target for antibiotics. | The bacterial cell wall is mainly composed of peptidoglycan, which is a three-dimensional network of long aminosugar strands located on the exterior of the cytoplasmic membrane. These strands consist of alternating MurNAc and GlcNAc units and are interlinked to each other via peptide moieties that are attached to the M... | 19,008,088 |
Peptide deformylase inhibitors of Mycobacterium tuberculosis: synthesis, structural investigations, and biological results. | Bacterial peptide deformylase (PDF) belongs to a subfamily of metalloproteases catalyzing the removal of the N-terminal formyl group from newly synthesized proteins. We report the synthesis and biological activity of highly potent inhibitors of Mycobacterium tuberculosis (Mtb) PDF enzyme as well as the first X-ray crys... | 19,008,098 |
Construction of a fusion protein expression vector pGS/2SS-M4GFP without antibiotic resistance gene and its subcellular localization in different cell lines. | A novel plasmid pGS/2SS-M4GFP was constructed in the present study by recombination of GS/2SS gene and enhanced green fluorescent protein (M4GFP) sequence. The GS/2SS fusion gene encoding two copies of somatostatin genes was firstly introduced into pVAX-asd vector in which the kanamycin resistance cassette was replaced... | 19,008,122 |
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. | Visceral leishmaniasis (VL) remains a public health problem in most countries bordering the Mediterranean basin. Its diagnosis is challenging and often delayed, as the main clinical picture is often indistinguishable from that of other infectious and non-infectious diseases. Herein, we report two unusual cases of VL th... | 19,008,139 |
Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice. | Proliferating cell nuclear antigen (PCNA) encircles DNA as a ring-shaped homotrimer and, by tethering DNA polymerases to their template, PCNA serves as a critical replication factor. In contrast to high-fidelity DNA polymerases, the activation of low-fidelity translesion synthesis (TLS) DNA polymerases seems to require... | 19,008,189 |
Immunoglobulin class switch recombination: study through human natural mutants. | Immunoglobulin class switch recombination deficiencies in humans are exquisite models to analyse the mechanisms of class switch recombination (CSR). Besides defects in CD40L/CD40 interaction, others result from an intrinsic B-cell deficiency. The recent elucidation of the molecular basis of some of them has made it pos... | 19,008,192 |
APOBEC3G: an intracellular centurion. | The intrinsic antiretroviral factor APOBEC3G (A3G) is highly active against HIV-1 and other retroviruses. In different cell types, A3G is expressed in high-molecular-mass (HMM) RNA- protein complexes or low-molecular-mass (LMM) forms displaying different biological activities. In resting CD4 T cells, a LMM form of A3G ... | 19,008,196 |
Cephalopod dynamic camouflage: bridging the continuum between background matching and disruptive coloration. | Individual cuttlefish, octopus and squid have the versatile capability to use body patterns for background matching and disruptive coloration. We define--qualitatively and quantitatively--the chief characteristics of the three major body pattern types used for camouflage by cephalopods: uniform and mottle patterns for ... | 19,008,200 |
p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide. | The gamma-secretase complex cleaves many transmembrane proteins, including amyloid precursor protein, EphB and ErbB tyrosine kinase receptors, Notch1 receptors, and adhesion factors. Presenilin 1, the catalytic subunit of gamma-secretase, associates with the cadherin/catenin cell-cell adhesion/communication system and ... | 19,008,223 |
Evaluation of spatiotemporal organization of persistent atrial fibrillation with time- and frequency-domain measures in humans. | Areas with complex fractionated electrograms are commonly targeted during ablation of persistent atrial fibrillation (AF). These signals are, however, found in most sampled areas of the left atrium (LA), implying the need for further differentiation. Electrograms were recorded over 60 s at eight different LA endocardia... | 19,008,240 |
Quantitative analysis of elevated serum Golgi protein-73 expression in patients with liver diseases. | Golgi protein-73 (GP73) is a newly identified candidate serum marker for liver diseases. The utility of this biomarker remains limited, largely due to the lack of quantitative information. The aims of this study were to quantify serum GP73 (sGP73) in healthy individuals and in patients with liver diseases, and to valid... | 19,008,260 |
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