title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Determination of chemical warfare agents: Gas chromatographic analysis of ethylarsine dichloride by derivatization with dithiols (3rd Communication). | Ethylarsine dichloride was used during WW I as a chemical warfare agent. Residues of this chemical warfare agent and its metabolites are still present today and continue to contaminate soil and water. A gas Chromatographic method for the detection and determination of ethylarsine dichloride is shown. Six dithiols were ... | 19,005,811 |
A study of BTEX-ratios in the urban area of Munich/Germany using rapid gas chromatography. | During October 1993 rapid in-situ quasi-continuous GC/FID measurements of aromatic compounds (BTEX) were carried out at two urban sites in Munich/Germany. A cycle time of 10 min allowed determination of shorttime BTEX emission variations and their impact on selected BTEX ratios. The ethylbenzene/ Sigmam/p-xylene ratio ... | 19,005,812 |
Phosphine by bio-corrosion of phosphide-rich iron. | Phosphine is a toxic agent and part of the phosphorus cycle. A hitherto unknown formation mechanism for phosphine in the environment was investigated. When iron samples containing iron phosphide were incubated in corrosive aquatic media affected by microbial metabolites, phosphine was liberated and measured by gas chro... | 19,005,813 |
Ecological recovery of vegetation at a former industrial sludge basin and its implications to phytoremediation. | Examination of a former industrial sludge basin containing organic pollutants showed that the basin had undergone substantial ecological recovery through natural forces following the removal of surface water in 1982. Conventional phases of ecological recovery (plant invasion and succession) have occurred, but the struc... | 19,005,834 |
Efavirenz Mannich bases: synthesis, anti-HIV and antitubercular activities. | A series of efavirenz Mannich bases has been synthesized by reacting efavirenz, formaldehyde, and various aryl substituted piperazines using microwave irradiation (yield 35-88%). The synthesized compounds were evaluated for in-vitro anti-HIV and antimycobacterial activities. The in-vitro antiretroviral activities indic... | 19,005,871 |
From psychosurgery to neuromodulation: deep brain stimulation for intractable Tourette syndrome. | Tourette syndrome is a neuropsychiatric disorder characterized by motor and vocal tics. It is often associated with depression, obsessive-compulsive symptoms, self-injurious behaviour and attention deficit-hyperactivity disorder (ADHD). In intractable patients, neuromodulation using deep brain stimulation (DBS) has wid... | 19,005,877 |
Long-term mortality trends in functionally-dependent adults following severe traumatic-brain injury. | To investigate mortality trends in functionally dependent adults following traumatic brain injury (TBI). Data for 966 consecutive admissions to a specialist TBI rehabilitation service were reviewed. Details for 69 subjects who were functionally dependent at rehabilitation discharge were cross-referenced against the Sta... | 19,005,883 |
Melatonin and environmental lighting regulate ALA-S gene expression and So porphyrin biosynthesis in the rat harderian gland. | The main porphyrin in rodent Harderian glands (HGs) is the heme precursor protoporphyrin IX (PPIX). Rhythmic variations in PPIX levels have yet to be studied in rodent HGs. Moreover, the mode of regulation of heme biosynthesis in this organ is poorly documented in the rat. The aim of this study was to determine day-nig... | 19,005,892 |
Novel methods for tendon investigations. | Tendon structures have been studied for decades, but over the last decade, methodological development and renewed interest for metabolic, circulatory and tissue protein turnover in tendon tissue has resulted in a rising amount of investigations. This paper will detail the various modern investigative techniques availab... | 19,005,915 |
Correlates of functional fitness in older adults. | Self-efficacy has been shown to be both an antecedent and determinant of behaviors such as physical activity and may explain variance in the performance of functional tasks among older adults. The objectives of the current study were: first, to identify potential latent factors of functional fitness (i.e., the ability ... | 19,005,931 |
Use of MP3 players to increase asthma knowledge in inner-city African-American adolescents. | Low-income African-American adolescents suffer a disproportionate burden of asthma morbidity. To evaluate the ability of our intervention, the Adolescents' Disease Empowerment and Persistency Technology (ADEPT) for asthma, to increase asthma knowledge in our target population. This was a 14-week (2-week run-in and 12-w... | 19,005,935 |
Novel polymeric nanoparticles containing tanshinone IIA for the treatment of hepatoma. | Novel polylactic acid nanoparticles containing tanshinone IIA (TS-PLA-NPs) were synthesized by a single oil-in-water emulsion/solvent evaporation method. In this study, the optimized nanoparticles were characterized for morphology, mean particle size, zeta potential, entrapment efficiency, drug-loading content, X-ray d... | 19,005,937 |
Copper (II) and zinc (ii) metal-based salicyl-, furanyl-, thienyl- and pyrrolyl-derived ONNO, NNNO, ONNS & NNNS donor asymmetrically mixed schiff-bases with antibacterial and antifungal potentials. | A new series of asymmetric salicyl-, furanyl-, thienyl- and pyrrolyl-derived ONNO, NNNO, ONNS & NNNS donor antibacterial and antifungal Schiff-bases and their copper(II) and zinc(II) metal complexes have been synthesized and characterized. IR spectra indicated the ligands to act as quartdentate towards divalent met... | 19,005,942 |
A portable method for assessing gastrointestinal motility by simultaneously measuring transit time and contraction frequency. | To portably monitor the motility of the total GI tract, a method for assessing GI motility by simultaneously measuring transit time and contraction frequency is put forward. The portable monitoring system is composed of a swallowable telemetric capsule, a portable recorder, magnetizing coils deposited in vitro, and wor... | 19,005,962 |
The effect of applied pressure on the electrical impedance of the bladder tissue using small and large probes. | There are a number of studies using electrical impedance spectroscopy, a minimally invasive technique, as a tissue characterizing method with different probe sizes (usually with larger probe diameters than that used in this work). In urinary bladder studies the probe size are limited to 2 mm diameter, in order to pass ... | 19,005,965 |
Lactobacillus fermentum BR11 and fructo-oligosaccharide partially reduce jejunal inflammation in a model of intestinal mucositis in rats. | Although probiotics are beginning to enter mainstream medicine for disorders of the colon, their effects on the small bowel remain largely unexplored. We investigated the recently identified probiotic, Lactobacillus fermentum (L. fermentum) BR11 (BR11) and the prebiotic, fructo-oligosaccharide (FOS), both individually ... | 19,005,975 |
Effect of Greek raisins (Vitis vinifera L.) from different origins on gastric cancer cell growth. | Currants and Sultanas (Vitis vinifera L.) are dried vine products produced in Greece and used broadly in the Mediterranean diet. We aimed to investigate the gastric cancer preventive activity of methanol extracts obtained from currants from three different origins in Greece (Vostizza, Nemea, and Messinia) as well as me... | 19,005,979 |
Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids. | Dietary flavonoids have been shown to be protective against various types of cancers. Here we studied the effects of 12 different flavonoids and other substances on cell proliferation and VEGF expression in human ovarian cancer cells, OVCAR-3. Cell growth was determined to pinpoint the best time for drug treatment. By ... | 19,005,980 |
[Evidence-based ophthalmology: critical evaluation of the literature in relation to diagnostic tests]. | In general, articles on diagnostic tests have a very poor methodological quality. If we translate their conclusions to daily practice without a proper analysis it is easy to see a typical trend: physicians use new (and expensive) tests without increasing diagnostic capacity; they only increase the health budget. Eviden... | 19,006,016 |
[The Gerbode defect - a left ventricle to right atrium communication]. | We present a rare case of left ventricular to right atrial communication - a Gerbode type defect discovered in an adult man with systolic murmur at the left sternal border in physical exam. We report this case because this congenital defect is very rare, more often this pathology was reported after trauma, endocarditis... | 19,006,037 |
[67-year-old patient with speech disorder and dysphagia]. | A 67-year-old man who had been heart transplanted ten years before was admitted to our hospital because of diarrhea. During his stay he developed a severe lingual and facial angioedema. After excluding hereditary angioedema caused by a deficiency in functional C1 esterase inhibitor we focused on adverse effects of his ... | 19,006,046 |
Small-cell neuroendocrine carcinoma originating from the lateral nasopharyngeal wall. | A 40-year-old man presented with right-sided nasal blockage and epistaxis of 18 months' duration. Examination revealed a pinkish mass in the right nasal cavity and nasopharynx. Initial biopsy was suggestive of angiofibroma. Complete excision through a lateral rhinotomy approach was performed. The postoperative histopat... | 19,006,052 |
Single-cell-based image analysis of high-throughput cell array screens for quantification of viral infection. | The identification of eukaryotic genes involved in virus entry and replication is important for understanding viral infection. Our goal is to develop a siRNA-based screening system using cell arrays and high-throughput (HT) fluorescence microscopy. A central issue is efficient, robust, and automated single-cell-based a... | 19,006,066 |
Ultrasound treatment of cutaneous side-effects of infused apomorphine: a randomized controlled pilot study. | Apomorphine hydrochloride is a dopamine agonist used in the treatment of advanced Parkinson's disease. Its administration by subcutaneous infusions is associated with the development of nodules that may interfere with absorption of the drug. This pilot study assessed the effectiveness of ultrasound (US) in the treatmen... | 19,006,068 |
Identification of a MYO18A-PDGFRB fusion gene in an eosinophilia-associated atypical myeloproliferative neoplasm with a t(5;17)(q33-34;q11.2). | Chromosomal aberrations of 5q31-33 associated with rearrangements of the platelet-derived growth factor receptor beta (PDGFRB) gene are rare but recurrent in patients with eosinophilia-associated atypical myeloproliferative neoplasms (Eos-MPNs). We used a DNA-based "long-distance inverse PCR" (LDI-PCR) to identify a ne... | 19,006,078 |
CADASIL: extended polymorphisms and mutational analysis of the NOTCH3 gene. | CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 different... | 19,006,080 |
Presynaptic muscarinic receptors, calcium channels, and protein kinase C modulate the functional disconnection of weak inputs at polyinnervated neonatal neuromuscular synapses. | We studied the relation among calcium inflows, voltage-dependent calcium channels (VDCC), presynaptic muscarinic acetylcholine receptors (mAChRs), and protein kinase C (PKC) activity in the modulation of synapse elimination. We used intracellular recording to determine the synaptic efficacy in dually innervated endplat... | 19,006,081 |
Enriched environment restores hippocampal cell proliferation and ameliorates cognitive deficits in chronically stressed rats. | Adult neurogenesis, particularly in the subgranular zone, is thought to be linked with learning and memory. Chronic stress inhibits adult hippocampal neurogenesis and also impairs learning and memory. On the other hand, exposure to enriched environment (EE) is reported to enhance the survival of new neurons and improve... | 19,006,089 |
Immunization with pseudotype baculovirus expressing envelope protein of Japanese encephalitis virus elicits protective immunity in mice. | Japanese encephalitis (JE) is a serious infection and disease in southern and eastern Asia. The design and development of safer and more efficacious vaccines against Japanese encephalitis virus (JEV) is a high-priority target in the world. Recently, baculovirus pseudotyped with vesicular stomatitis virus glycoprotein (... | 19,006,097 |
Tetralogy of Fallot: the oldest reported survivor of Brock's procedure. | We report the case of a 79-y-old male with Tetralogy of Fallot (TOF) who underwent Brock's procedure in his twenties and has survived event-free. Brock's procedure, which entailed infundibular resection and pulmonary valvotomy, has been associated with complications including the need for re-operation, pulmonary regurg... | 19,006,112 |
Synthesis of beta-peptides with beta-helices from new C-linked carbo-beta-amino acids: study on the impact of carbohydrate side chains. | The design and synthesis of beta-peptides from new C-linked carbo-beta-amino acids (beta-Caa) presented here, provides an opportunity to understand the impact of carbohydrate side chains on the formation and stability of helical structures. The beta-amino acids, Boc-(S)-beta-Caa((g))-OMe 1 and Boc-(R)-beta-Caa((g))-OMe... | 19,006,129 |
Toluene dioxygenase-catalyzed synthesis of cis-dihydrodiol metabolites from 2-substituted naphthalene substrates: assignments of absolute configurations and conformations from circular dichroism and optical rotation measurements. | cis-Dihydrodiol metabolites have been isolated from naphthalene and six 2-substituted naphthalene substrates. Their structures and absolute configurations have been determined by a combination of calculated (TDDFT) and experimentally based circular dichroism (CD) and optical rotation (OR) methods. The "inverse" styrene... | 19,006,170 |
Human embryonic stem cells and cardiac cell fate. | Human embryonic stem (HES) cells are pluripotent and give rise to any cell lineage. More specifically, how the first embryonic lineage (i.e., cardiac lineage) is acquired remains in many aspects questionable. Herein, we summarize the protocols that have been used to direct the fate of HES cells toward the cardiomyocyti... | 19,006,174 |
Stereoselective analysis of labetalol in human plasma by LC-MS/MS: application to pharmacokinetics. | Labetalol is clinically available as a mixture of two racemates (four stereoisomers). The stereoisomer (R,R) has as main activity the beta1-antagonism and the stereoisomer (S,R) is highly selective for the alpha1 adrenoceptor and is responsible for most of the alpha-blocker activity. In the present investigation, a met... | 19,006,203 |
Paternal somatic mosaicism of a TGFBR2 mutation transmitting to an affected son with Loeys-Dietz syndrome. | We report on somatic mosaicism of a TGFBR2 missense mutation, c.1336G>A (D446N). The affected son with the heterozygous mutation was previously reported [Sakai et al. (2006); Am J Med Genet A 140A:1719-1725]. Further evaluation indicates his clinical condition is Loeys-Dietz syndrome. Parental blood samples were stu... | 19,006,214 |
Genetic origins and clinical phenotype of familial and acquired erythrocytosis and thrombocytosis. | Familial and acquired erythrocytosis and thrombocytosis are characterized by myeloid lineage hyperproliferation, which is either single or multi-lineage in origin. The single lineage disorders exhibit Mendelian inheritance with polyclonal hematopoiesis and often arise from a single genetic defect. In contrast, the mult... | 19,006,225 |
Gender affects survival for medulloblastoma only in older children and adults: a study from the Surveillance Epidemiology and End Results Registry. | Males have a higher incidence of medulloblastoma (MB) than females, but the effect of gender on survival is unclear. Studies have yielded conflicting results, possibly due to small sample sizes or differences in how researchers defined MB. We aimed to determine the effect of gender on survival in MB using a large data ... | 19,006,250 |
Bone marrow minimal disseminated disease (MDD) and minimal residual disease (MRD) in childhood T-cell lymphoblastic lymphoma stage III, detected by flow cytometry (FC) and real-time quantitative polymerase chain reaction (RQ-PCR). | Despite overlapping features of T-cell lymphoblastic lymphoma (T-LLy) and T-cell acute lymphoblastic leukemia (T-ALL), which respond favorably to T-ALL treatment, clinical and biological differences exist. We retrospectively assessed the prevalence of submicroscopic bone marrow (BM) minimal disseminated disease (MDD) a... | 19,006,253 |
Spatial distribution enhancement of sonoluminescence activity by altering sonication and solution conditions. | An intensified charge-couped device (CCD) camera was used to capture raw images of multibubble sonoluminescence, generated by 168 and 448 kHz ultrasound. The effect of various air and surfactant concentrations, and pulse conditions on the acoustic pressure distribution, percentage of standing wave component, the struct... | 19,006,270 |
Distribution of binding energies of a water molecule in the water liquid-vapor interface. | Distributions of binding energies of a water molecule in the water liquid-vapor interface are obtained on the basis of molecular simulation with the SPC/E model of water. These binding energies together with the observed interfacial density profile are used to test a minimally conditioned Gaussian quasi-chemical statis... | 19,006,274 |
Performance of block correlated coupled cluster method with the CASSCF reference function for the prediction of activation barriers, spectroscopic constants in diatomic molecules, and singlet-triplet gaps in diradicals. | The spatial orbital formulations of block correlated coupled cluster (BCCC) theory with a general CASSCF reference function (CAS-BCCC in short) is derived and an efficient implementation of this approach at the four-block correlation level (abbreviated CAS-BCCC4) is reported. We have applied the CAS-BCCC4 approach to i... | 19,006,279 |
Range separation and local hybridization in density functional theory. | Kohn-Sham density functional theory has become a standard method for modeling energetic, spectroscopic, and chemical reactivity properties of large molecules and solids. Density functional theory provides a rigorous theoretical framework for modeling the many-body exchange-correlation effects that dominate the computat... | 19,006,280 |
Ion partitioning at the liquid/vapor interface of a multicomponent alkali halide solution: a model for aqueous sea salt aerosols. | The chemistry of Br species associated with sea salt ice and aerosols has been implicated in the episodes of ozone depletion reported at Arctic sunrise. However, Br(-) is only a minor component in sea salt, which has a Br(-)/Cl(-) molar ratio of approximately 0.0015. Sea salt is a complex mixture of many different spec... | 19,006,284 |
Analysis of the critical step in catalytic carbodiimide transformation: proton transfer from amines, phosphines, and alkynes to guanidinates, phosphaguanidinates, and propiolamidinates with Li and Al catalysts. | While lithium amides supported by tetramethylethylenediamine (TMEDA) are efficient catalysts in the synthesis of substituted guanidines via the guanylation of an amine with carbodiimide, as well as the guanylation of phosphines and conversion of alkynes into propiolamidines, aluminum amides are only efficient catalysts... | 19,006,297 |
Silver ion-induced Grob fragmentation of gamma-amino iodides: highly stereoselective synthesis of polysubstituted piperidines. | A new concerted silver ion-mediated Grob fragmentation process is described in which a 1,2-dihydropyridinium ion is formed and trapped in situ with Grignard reagents in a highly regio- and diastereoselective fashion. Using this methodology, 2,3,6-trisubstituted piperidines were synthesized in good yields and further de... | 19,006,316 |
Determination of ground-state hole-transfer rates between equivalent sites in oxidized multiporphyrin arrays using time-resolved optical spectroscopy. | Excited-state charge separation in molecular architectures has been widely explored, yet ground-state hole (or electron) transfer, particularly involving equivalent pigments, has been far less studied, and direct quantitation of the rate of transfer often has proved difficult. Prior studies of ground-state hole transfe... | 19,006,413 |
Interactions between trace metals (Cu, Hg, Ni, Pb) and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Antarctic fish Trematomus bernacchii: oxidative effects on biotransformation pathway. | Biological effects of chemical mixtures are an emerging issue when using biomarkers in field conditions, because synergistic or inhibitory interactions, cascade, and indirect mechanisms can both enhance or suppress responses to specific classes of pollutants. The Antarctic rock cod (Trematomus bernacchii) was exposed t... | 19,006,418 |
Perspectives on health care of adults with developmental disabilities. | A focus group study was conducted with individuals with developmental disabilities to understand their perspectives on their health status, health promotion behaviors, and health care services they receive. The majority of participants reported good to excellent health, and all had some form of medical insurance. Howev... | 19,006,428 |
Use of erythropoiesis-stimulating agents among chemotherapy patients with hemoglobin exceeding 12 grams per deciliter. | Prior to 2007, the erythropoiesis-stimulating agents (ESAs) epoetin alfa and darbepoetin alfa were indicated for use in chemotherapyinduced anemia to achieve target hemoglobin (Hb) levels of approximately 12 grams per deciliter (gm per dL), and treatment was to be withheld if Hb exceeded 13 gm per dL. In March 2007, th... | 19,006,442 |
Self-reported use of pharmaceuticals among patients with irritable bowel syndrome in primary care. | Irritable bowel syndrome (IBS) has an estimated 10%-12% prevalence in industrial countries. Studies from the United States have shown that IBS causes notable financial losses for employers. Due to the lack of pathophysiological markers, only a fraction of the pharmacological management of IBS has focused on etiological... | 19,006,443 |
Immunological response to peptide nucleic acid and its peptide conjugate targeted to transactivation response (TAR) region of HIV-1 RNA genome. | Anti-human immunodeficiency virus-1 (HIV-1) polyamide (peptide) nucleic acids (PNAs) conjugated with cell-penetrating peptides (CPPs) targeted to the viral genome are potent virucidal and antiviral agents. Earlier, we have shown that the anti-HIV-1 PNA(TAR)-penetratin conjugate is rapidly taken up by cells and is nonto... | 19,006,449 |
Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells. | Bone marrow is the traditional source of human multipotent mesenchymal stem cells (MSCs), but placenta appears to be an alternative and more readily available source. This study comprehensively compared human placenta-derived MSC (hpMSC) and human bone marrow-derived MSC (hbmMSC) in terms of cell characteristics, optim... | 19,006,451 |
Functional analysis of embryonic stem cell-derived glial cells after integration into hippocampal slice cultures. | Embryonic stem (ES) cell-derived neural progenitor cells (ESNPs) generated in vitro are multipotent progenitors which can differentiate into oligodendrocytes, astrocytes, and neurons. Given the exciting prospects for ES cell-based treatments of neurological disorders, several studies investigated the migration, integra... | 19,006,454 |
Managing neoplastic bone disease with ibandronic acid: a preclinical and clinical data update. | Bisphosphonates are the standard of care for treating and preventing the complications of bone metastases. Ibandronic acid is available in effective and well-tolerated oral (50 mg daily) and intravenous (6 mg via > or = 15 min infusion every 3-4 weeks) formulations. This paper reviews the latest preclinical and clin... | 19,006,482 |
Idiopathic inflammatory myopathies. | The idiopathic inflammatory myopathies are a group of systemic autoimmune syndromes characterized by striated muscle inflammation. Here, we discuss the clinical features of this group of conditions and review the recent developments in the understanding of the pathogenesis and immunogenetics of the idiopathic inflammat... | 19,006,486 |
Implantable loop recorders: a viable diagnostic tool in veterinary medicine. | The purpose of this study was to investigate whether implantable loop recorders could be used in the diagnosis of unexplained collapse in dogs. The medical records of six dogs presented to the University of Liverpool Small Animal Teaching Hospital between May 2003 and October 2006 for further evaluation of intermittent... | 19,006,489 |
Variability in malaria prophylaxis prescribing across Europe: a Delphi method analysis. | The indications for prescribing malaria chemoprophylaxis lack a solid evidence base that results in subjectivity and wide variation of practice across countries and among professionals. European experts in travel medicine, who are members of TropNetEurop, participated in a survey conducted using the Delphi method. This... | 19,006,501 |
Leishmaniasis, an emerging imported infection: report of 20 cases from Australia. | Leishmaniasis is a protozoan infection rarely reported in Australia. However, with the advent of increased international tourism and migration of refugees from endemic regions, leishmaniasis has emerged as an increasingly imported infection. We report 20 cases (17 cutaneous, 2 visceral, and 1 post-kala-azar dermal leis... | 19,006,509 |
A patient with paratyphoid A fever: an emerging problem in Asia and not always a benign disease. | A 15-year-old Nepalese boy with fever was thought to have enteric fever and started on cefixime. His blood culture grew Salmonella paratyphoid A. On the sixth day, he developed gastrointestinal bleeding, disseminated intravascular coagulation, and later, acute respiratory distress syndrome. He succumbed to his illness ... | 19,006,513 |
Plasma levels of asymmetric dimethylarginine in premature neonates: its possible involvement in developmental programming of chronic diseases. | The endothel dysfunction in early life may play a role in developmental programming of cardiovascular morbidity. The changes of dimethylarginines' plasma levels during the first month among preterm infants and their determinants had been investigated in our study. Twenty preterm infants of healthy mothers were studied.... | 19,006,524 |
The effects of guideline implementation for proton pump inhibitor prescription on two pulmonary medicine wards. | It has been demonstrated that 40% of patients admitted to pulmonary medicine wards use proton pump inhibitors (PPIs) without a registered indication. To assess whether implementation of a guideline for proton pump inhibitor (PPI) prescription on pulmonary medicine wards could lead to a decrease in use and improved appr... | 19,006,542 |
Long-term proton pump inhibitor use and gastrointestinal cancer. | Proton pump inhibitors profoundly affect the stomach and have been associated with carcinoid tumors in female rats. There is now sufficient experience with this class of drugs to allow reasonable estimation of their safety in terms of cancer development in humans. Long-term use of proton pump inhibitors is associated w... | 19,006,608 |
Mucolipidosis type IV in a Turkish boy associated with a novel MCOLN1 mutation. | Mucolipidosis type IV is a rare neurodegenerative lysosomal storage disorder that usually presents during the first year of life with severe mental retardation, delayed motor milestones and corneal opacities. Mucolipidosis IV is caused by mutations in MCOLN1, a gene encoding mucolipin-1 which is responsible for maintai... | 19,006,653 |
Comparison of daily physical activity between COPD patients from Central Europe and South America. | In healthy elderly and adults, lower physical activity level in daily life has been associated with lower socio-economic level and non-Caucasian race. The objective of this study was to determine if this is also applicable in chronic obstructive pulmonary disease (COPD) by comparing physical activity levels in daily li... | 19,006,659 |
The combination of docetaxel and cisplatin plus fluorouracil as neoadjuvant chemotherapy in the treatment of T4 stage gastric cancer. | The prognosis of local advanced gastric carcinoma is very poor. We evaluated the impact on survival and the effects induced by the triple combination docetaxel-cisplatin-fluorouracil (DCF) as neoadjuvant chemotherapy in 24 T4 stage gastric tumor patients. They received 2-3 cycles DCF chemotherapy, followed by radical g... | 19,006,661 |
Synthesis and biological activity of previtamin D(3) analogues with A-ring modifications. | Synthesis of two novel 6-s-cis analogues of 1alpha,25-dihydroxyvitamin D3 are described using shikimic acid and its 4-epi isomer as versatile chiral starting materials. These derivatives contain a 2beta-(3'-hydroxypropoxy) moiety or a 2beta,3beta-epoxy group into 1alpha,25-OH(2)-19-nor-pre-D3. The synthesized analogues... | 19,006,670 |
Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists. | We recently described the synthesis of 1-benzyl-3-propyl-1H,8H-imidazo[2,1-f]purine-2,4-diones, new potent and selective A(3) adenosine receptor antagonists containing a xanthine core. The present work can be considered an extension of our SAR studies on related structures in which the effect of different kind of subst... | 19,006,671 |
Moving beyond "the down low": a critical analysis of terminology guiding HIV prevention efforts for African American men who have secretive sex with men. | HIV continues to affect African American populations in the United States at disproportionate levels. Recent reports have described potentially high-risk behaviors of African American men who identify as heterosexual but who engage in secretive sex with other men. These men have been referred to as being "on the Down L... | 19,006,674 |
Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy. | Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction in adults in Western society. Paradoxically, relatively little is known about the pathobiological mechanisms associated with the progressive loss of neural tissue in the spinal cord of CSM patients. In this report we have utilized... | 19,006,686 |
A notch in the toll belt. | Two cell response pathways, Toll-like receptor (TLR) and Notch, conserved from Drosophila to mammals are well characterized for distinct roles in innate immunity and cell development, respectively. In this issue of Immunity, Hu et al. (2008) describe and characterize the direct cooperation of these two pathways. | 19,006,687 |
"Dangerous crystals". | Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known. In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol. | 19,006,690 |
Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology. | Chronic viral infections of the hematopoietic system are associated with bone marrow dysfunction, to which both virus-mediated and immune-mediated effects may contribute. Using unresolving noncytopathic Friend virus (FV) infection in mice, we showed that unregulated CD4(+) T cell response to FV caused IFN-gamma-mediate... | 19,006,695 |
Intracorneal inlay for the surgical correction of presbyopia. | To evaluate the clinical safety and efficacy of the ACI-7000 intracorneal inlay in increasing the depth of field in emmetropic presbyopic patients. Beyoglu Eye Research and Education Hospital, Istanbul, Turkey. This prospective unmasked study comprised 39 presbyopic patients; 12 were naturally emmetropic and 27 had emm... | 19,006,739 |
Toxic endothelial cell destruction syndrome after intraocular lens repositioning with intracameral epinephrine. | A 66-year-old Chinese man developed corneal endothelial decompensation after intraocular lens (IOL) repositioning using intracameral epinephrine was performed. The presentation was compatible with toxic endothelial cell destruction syndrome, which is caused by prolonged, direct exposure of the corneal endothelium to re... | 19,006,750 |
Reliability and validity of the German version of "the Patient-rated Wrist Evaluation (PRWE)" as an outcome measure of wrist pain and disability in patients with acute distal radius fractures. | The aim was to test the reliability and validity of the German version of the Patient-rated Wrist Evaluation (PRWE) for patients with acute distal radius fractures. To estimate the reliability and construct validity, 44 patients completed a questionnaire booklet containing the German PRWE, the Short Form-36 (SF-36), an... | 19,006,763 |
Ectopic pregnancy: a pictorial review. | Ultrasound has remained the primary modality for investigating the pelvis of women in the reproductive age group, especially in an emergency setting. Recognition of different sonographic presentations, including typical and atypical findings of ectopic pregnancy, is important to determine surgical or nonsurgical manage... | 19,006,776 |
Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy. | To study cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy. Newly collected time-concentrations profiles and reported studies investigating cefazolin disposition (plasma, amniotic fluid) were pooled. Nonlinear mixed effect modeling was applied. A 2-compartment linear disposition model wa... | 19,006,783 |
Surgical treatment of endometriosis: location and patterns of disease at reoperation. | To assess the behavior of revised American Fertility Society stages I and II endometriosis after surgical treatment, by observation of location of pelvic involvement at reoperation. Prospective study. Tertiary referral center at a university-based hospital. Thirty-nine women with persistent or recurrent chronic pelvic ... | 19,006,792 |
[Cytokine profile and level of antibodies after administration of split-vaccine against influenza to adults]. | Serum concentrations of cytokines (IFN-gamma, TNF-alpha, IL-2, IL-4, IL-6, IL-8) and antibody levels to influenza virus antigens were studied in adults vaccinated with split-vaccine against influenza. Analysis of antibody titers 21 days after vaccination compared with baseline levels revealed high immunogenicity of vac... | 19,006,832 |
Polymyalgia rheumatica in a renal transplant patient. | A 56-year-old African American woman who was on triple immunosuppressive therapy (which includes tacrolimus, mycophenolate mofetil, and prednisone) for a renal transplant that she had received 10 years ago presented with malaise, low-grade fevers and severe bilateral pain in her shoulder, neck and thigh muscles. There ... | 19,006,913 |
[The 6 top-selling prescription drugs--an interactive evidence-based CME module for GPs on pharmacotherapy]. | The Bremen General Practitioner's Association developed an interactive education tool about top-selling drugs in the GP setting. The data on various high-priced drugs identified by systematic literature search were processed by small work groups during several training courses for general practitioners and the results ... | 19,006,915 |
[Randomised controlled trials (RCTs)]. | Randomisation is regarded as an essential principle ensuring the internal validity of clinical trials. This is why randomised controlled trials (RCTs) lead every evidence hierarchy of therapeutic interventions. At the same time, there are controversies about the role of RCTs in health research. The article addresses th... | 19,006,920 |
The animal-human interface and infectious disease in industrial food animal production: rethinking biosecurity and biocontainment. | Understanding interactions between animals and humans is critical in preventing outbreaks of zoonotic disease. This is particularly important for avian influenza. Food animal production has been transformed since the 1918 influenza pandemic. Poultry and swine production have changed from small-scale methods to industri... | 19,006,971 |
Animals as early detectors of bioevents: veterinary tools and a framework for animal-human integrated zoonotic disease surveillance. | The threat of bioterrorism and emerging infectious diseases has prompted various public health agencies to recommend enhanced surveillance activities to supplement existing surveillance plans. The majority of emerging infectious diseases and bioterrorist agents are zoonotic. Animals are more sensitive to certain biolog... | 19,006,972 |
Risk factors associated with anthrax outbreak in animals in North Dakota, 2005: a retrospective case-control study. | We identified the risk factors associated with the anthrax outbreak Of 2005 in animals in North Dakota. Medical records of the 2005 anthrax outbreak were obtained from the Veterinary Diagnostic Laboratory at North Dakota State University. Additional data were obtained from the North Dakota state veterinarian's office, ... | 19,006,977 |
Brief interventions for alcohol problems: factors that facilitate implementation. | Brief interventions are gaining favor as a means of addressing the problems associated with hazardous and harmful drinking. Brief interventions commonly target people whose levels or patterns of use are not diagnosable as alcohol abuse or dependence. These interventions usually are delivered by professionals who do not... | 19,006,991 |
[Studies on separation and purification of Rhizoma Fagopyri Dibotoryis extract by macroporous resin]. | To establish a technical process for purification of extract of Rhizoma Fagopyri Dibotoryis. The static adsorption capacity and elution ratio of Mixture of proanthocyanidins tannic condensation were used as evaluation to select the best resin in 3 kinds of macroporous resin. The adsorptive characteristics and elution p... | 19,007,009 |
[Oral anticoagulation control in a cardiac surgery ward]. | In patients who undergo cardiac surgery, particularly valvular surgery it is essential to carry out frequent anticoagulation controls during their hospital stay The author questions if it is viable to carry out these controls by means of a portable coagulation meter which, in principle, can provide advantages in patien... | 19,007,028 |
The influence of lamivudine, stavudine and nevirapine on the pharmacokinetics of chlorpropamide in human subjects. | Diabetic patients tend to be prone to infections, and multiple drug therapy cannot be ruled out in the management of diabetes. The effect of three routinely prescribed antiretroviral (ARV) drugs on the pharmacokinetic profile of an antidiabetic drug, chlorpropamide, was investigated in 18 human subjects, who had recent... | 19,007,042 |
[The influence of gilt to the retention of the complete metal crown]. | To research the influence of gilt to the retention of the complete metal crown. Sixty Ni-Cr alloy complete metal crown were divided into three groups, control group (common Ni-Cr alloy complete metal crown), whole gold-plating group (whole gilding on the tissue surface of the inner Ni-Cr alloy complete metal crown), pa... | 19,007,070 |
[Comparison of clinical effect of different tapered gutta-percha root filling with warm vertical condensation]. | To compare the clinical effect of different tapered gutta-percha root filling by warm vertical condensation with immediate postoperative radiographs and one year follow-up. 40 maxillary anterior teeth with single, straight canals were divided into two equal groups. The teeth were instrumented with Hero 642 rotary nicke... | 19,007,071 |
[Investigation on dental impression disinfection knowledge grasped by medical staff in stomatological hospitals]. | To investigate the situation about the dental impression disinfection knowledge of the medical staff in stomatological hospitals. A questionnaire investigation was conducted on 582 medical staff in five Grade A Class Three stomatological hospitals. The investigation items included demographic characteristics and knowle... | 19,007,073 |
[Initial study on the discrimination of oral microorganisms with a metabonomics method]. | To establish the spectra of metabolites that coued be employed in identification of oral pathogenic bacteria, and try to find a convenient and rapid way to discriminate oral microorganisms. Suspensions of Streptococcus mutans ATCC 25175, Streptococcus sanguis ATCC 10556 and Lactobacillus acidophilus ATCC 4356 with same... | 19,007,080 |
[Effect of estrogen on heat shock protein 70 expression in rat masseter muscle]. | To investigate the effect of estrogen on heat shock protein (HSP) 70 expression in rat masseter muscle. Sixty twelve-week-old female Sprague-Dawley rats were randomly divided into three groups: Sham surgery group (control group), ovariectomy group (OVX group), ovariectomy with estradiol valerate replacement treatment g... | 19,007,086 |
Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. | Mur ligases have essential roles in the biosynthesis of peptidoglycan, and they represent attractive targets for the design of novel antibacterials. MurD (UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase) is the second enzyme in the series of Mur ligases, and it catalyzes the addition of D-glutamic acid (D-Glu) to the... | 19,007,109 |
Mechanical features of Plasmodium falciparum acyl carrier protein in the delivery of substrates. | The Acyl Carrier Protein (ACP) is a key element in the biosynthesis of fatty acids being responsible for the acyl group shuttling and delivery within a series of related enzymes. The molecular mechanism of the delivery process is poorly known, and its characterization is essential for in-depth understanding the biosynt... | 19,007,113 |
Phenolic acid nanoparticle formation in iron-containing aqueous solutions. | This paper presents results which show that the interaction between two phenolic acids, p-coumaric and caffeic acid, with iron results in the formation of meta-stable colloidal nano particles. The particles are characterized with dynamic light scattering and cryo-transmission electron microscopy. The results show that ... | 19,007,124 |
Comparative metabolic profiling reveals secondary metabolites correlated with soybean salt tolerance. | High-performance liquid chromatography-ultraviolet-electrospray ionization mass spectrometry (HPLC-UV-ESI-MS) and HPLC-ESI-MS(n) analysis methods were used for metabolic profiling and simultaneous identification of isoflavonoids and saponins in soybean seeds. Comparative targeted metabolic profiling revealed marked dif... | 19,007,129 |
Aromaticity and antiaromaticity in the low-lying electronic states of cyclooctatetraene. | The levels of aromaticity of the most important geometries on the ground-state (S(0)), lowest triplet-state (T(1)), and first singlet excited-state (S(1)) potential energy surfaces (PESs) for cycloocta-1,3,5,7-tetraene (COT) are assessed using a wide range of magnetic criteria including nucleus-independent chemical shi... | 19,007,145 |
Selenocysteine positional variants reveal contributions to copper binding from cysteine residues in domains 2 and 3 of human copper chaperone for superoxide dismutase. | The human copper chaperone for superoxide dismutase binds copper both in an Atx1-like MTCQSC motif in domain 1 and via a multinuclear cluster formed by two CXC motifs at the D3 dimer interface. The composition of the Cu(I) cluster has been investigated previously by mutagenesis of the CXC motif, and by construction of ... | 19,007,184 |
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