title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Combination chemotherapy in the management of superior vena caval obstruction in small-cell anaplastic carcinoma of the lung. | Among 225 consecutive patients with small-cell anaplastic bronchogenic carcinoma, 26 (11.5%) had superior vena caval obstruction when the malignancy was diagnosed. Of these 26 patients, a consecutive series of 22 were treated initially with combination chemotherapy (cyclophosphamide, methotrexate and CCNU, in some case... | 216,239 | [
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Dietary fiber and blood lipids: reduction of serum cholesterol in type II hyperlipidemia by guar gum. | Guar gum, a storage polysaccharide galactomannan and a form of dietary fiber, was administered to 10 patients with type II a or b hyperlipidemia for 2 weeks. Five grams of gum was given before each of three meals daily, either in a specially prepared soup or mixed with fruit juice or milk. No other deliberate change of... | 216,259 | [
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A myofibroblastic tumor. Infantile digital fibroma (recurrent digital fibrous tumor of childhood). | Infantile digital fibromas are distinctive tumors both clinically and morphologically. A unique light microscopic features in the presence of intracytoplasmic, spherical, eosinophilic inclusion bodies. Previous electron microscopic studies have shown these bodies to consist of fibrils; bundles of fibrils have also been... | 216,266 | [
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Arginine vasopressin metabolism in dogs. II. Modeling and system analysis. | System modeling and analysis methods were applied to interpret data regarding arginine vasopressin (AVP) metabolism in dogs. Based on this analysis a new nonlinear 3-pool model of AVP distribution and disposal was proposed and quantified; the model pools included the plasma, a receptor pool, and an extravascular nonrec... | 216,271 | [
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Cholinergic agents inhibit sodium transport across the isolated toad bladder. | Acetylcholine and carbamylcholine (carbachol) inhibited sodium transport across the toad bladder. This effect was blocked by atropine. Carbachol increased the uptake of 45Ca by isolated toad bladder epithelial cells. This increased 45Ca uptake was blocked by atropine, pentobarbital, or lanthanum chloride. The inhibitor... | 216,273 | [
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alpha-L-iduronate ring conformations in heparin and heparin derivatives. 13-C Nuclear-magnetic-resonance analysis and titration data for variously desulphated and periodate-oxidized heparins. | A heparin derivative that had been O/N-desulphated and re-N-acetylated was investigated by 13C n.m.r. spectroscopy and potentiometric titration. Three forms of uronic acid were observed, tentatively identified as beta-D-glucuronate, and two different forms of alpha-L-iduronate. A comparison of the n.m.r. spectra of hep... | 216,348 | [
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Origin and nature of correlations in the Ia feedback pathway of the muscle control system. | Mammalian primary muscle spindle endings receive two inputs from fusimotor fibres and length changes of their extrafusal environment. Both inputs are also powerful noise sources disturbing the discharge patterns of the receptors. In this paper emphasis is laid on the extrafusal component. It is shown that extrafusal mu... | 216,422 | [
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[Effects of cortisol on lipid and lipoprotein synthesis in rat hepatocytes]. | Under in vivo conditions cortisol induces moderate hyperlipidemia followed by an increase in the phospholipid and triglyceride concentrations in the blood and a decrease of cholesterol; similar changes were observed in the liver. At all time intervals studied cortisol inhibits the phospholipid and cholesterol syntheses... | 216,425 | [
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Alterations in lysosomes, catalase-containing organelles, mitochondria and plasma membrane fragments from hypertensive rat aorta and caudal artery. | Vascular smooth muscle (VSM) cells from hypertensive and normotensive rat aortae and caudal arteries were isolated by enzymatic techniques, homogenized, and fractionated by differential pelleting. By these techniques, only mitochondria could be enriched more than fivefold in any one fraction. The other organelles were ... | 216,441 | [
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Reactive glioma in intracranial sarcoma: a form of mixed sarcoma and glioma ("sarcoglioma"): report of eight cases. | The clinicopathologic features of eight new cases of combined intracranial sarcoma and glioma are described. This type of mixed cerebral tumor is histologically characterized by a peripheral distribution of the gliomatous elements in relation to a more centrally situated meningeal or intracerebral sarcoma, and by the f... | 216,476 | [
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Enhancement of simian virus 40 uptake by permissive, semi-permissive and non-permissive cells. | The uptake of simian virus 40 (SV40) by cells that are both non-permissive for virus replication and resistant to virus infection could be enhanced markedly by infecting the cells in presence of DEAE-dextran. Virus uptake by semi-permissive and permissive cells was also enhanced by DEAE-dextran. Optimum enhancement of ... | 216,528 | [
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Serial fiberoptic bronchoscopy during chemotherapy for small cell carcinoma of the lung: early detection of patients at high risk of relapse. | Serial fiberoptic bronchoscopic examinations were performed during intensive chemotherapy with a combination of drugs in 77 previously untreated patients with small cell carcinoma of the lung. Before treatment, bronchoscopic examination revealed evidence of cancer in 93 percent (70) of the 75 patients studied at that t... | 216,531 | [
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Measurements of total and regional tumor blood flow and organ blood flow using 99Tcm labelled microspheres. An experimental study in rats. | Cardiac output, regional tissue and arterial tumor blood flow were studied in rats, with 99Tcm labelled microspheres using a reference sample simultaneously drawn as the spheres were injected. Both cardiac output and regional blood flow can be estimated in absolute values (ml X min-1 X g-1). Cardiac output and normal t... | 216,551 | [
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Naloxone and intestinal motility. | It was supposed that the inhibition of intestinal peristalsis seen in animals and humans after abdominal surgery might be related to the release of endorphins, endogenous opiate receptor agonists, caused by the surgical stress and pain. However, naloxone, a potent morphine and endorphin antagonist, failed to block this... | 216,571 | [
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Pregnenolone biosynthesis in isolated cells of Snell rat adrenocortical carcinoma 494. | Adrenocorticotrophin (ACTH) produced an insignificant stimulation of pregnenolone biosynthesis from endogenous precursors in isolated cells prepared from the rat Snell adrenal carcinoma 494. On the addition of 25-hydroxycholesterol, the rate of pregnenolone synthesis increased 10-fold. These results, noting also the ve... | 216,596 | [
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[Obesity and adipose tissue. 2. Hormonal regulation of adipose tissue metabolism]. | The effects of hormones on human adipose tissue are reviewed with respect to the pathogenesis, prevention and therapy of obesity. Insulin. The insulin-resistance in the obese is associated with a decrease of the number of insulin receptor sites, which is likely to be secondary to increased insulin levels. Catecholamine... | 216,612 | [
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Lipid-protein interaction in reconstituted cytochrome c oxidase/phospholipid membranes. | Deuterium and 31P nuclear magnetic resonance have been employed in an investigation of the effect of cytochrome c oxidase (EC 1.9.3.1) on the structure of lecithin bilayers. Cytochrome c oxidase was isolated from beef heart mitochondria in lipid-free form and reconstituted as a functional enzyme in bilayers composed of... | 216,616 | [
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On the modification of adenosine kinase by thiols. | The catalytic activity of adenosine kinase (EC 2.7.1.20) from yeast is very labile. Even incubation with thiols provokes a loss of two thirds of its enzymatic activity. Concomitantly, two SH-groups appear on the enzyme in addition to the single SH-group already present in the untreated enzyme, the latter being absolute... | 216,617 | [
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Appearance of hCG-receptor after conversion of newborn ovarian cells into testicular structures by H-Y antigen in vitro. | In a previous report (Zenzes et al., 1978b) it was shown that dissociated ovarian cells of newborn rats in vitro, if exposed to H-Y antigen, reorganize into testicular structures. The current study was designed to see whether this morphological conversion also results in a functional conversion. The LH/hCG receptor was... | 216,626 | [
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Prevention of spontaneous leukemia in mice by oncornavirus immunization. | C57L, NIH, and SWR mice were immunized with inactivated Gross leukemia virus (GLV) and then mated with AKR males. Their F1 offspring were then immunized with the murine sarcoma virus pseudotype of GLV, MSV(GLV). The concentrations of infectious ecotropic AKR virus in tail extracts of immunized mice were 100- to 1,000-f... | 216,644 | [
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Acetate kinase from Veillonella alcalescens. Purification and physical properties. | Acetate kinase (ATP:phosphotransferase E.C.2.7.2.1) has been purified to a high state of purity from Veillonella alcalescens. The native enzyme had a molecular weight of 88,000, as determined by Sephadex G-150 gel filtration. The molecular weight of the monomeric enzyme, estimated from sodium dodecyl sulfate-polyacryla... | 216,674 | [
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Translation of capped and uncapped vesicular stomatitis virus and reovirus mRNA'S. Sensitivity to m7GpppAm and ionic conditions. | In an attempt to elucidate the role of the 5'-terminal 7-methylguanosine residue in translation of mammalian mRNAs, vesicular stomatitis virus (VS virus), and reovirus mRNAs containing and lacking this residue, and also Qbeta RNA, were translated in cell-free extracts from reticulocytes and wheat germ under a variety o... | 216,675 | [
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Identification of the iron-sulfur center of spinach ferredoxin-nitrite reductase as a tetranuclear center, and preliminary EPR studies of mechanism. | EPR spectroscopic and chemical analyses of spinach nitrite reductase show that the enzyme contains one reducible iron-sulfur center, and one site for binding either cyanide or nitrite, per siroheme. The heme is nearly all in the high spin ferric state in the enzyme as isolated. The extinction coefficient of the enzyme ... | 216,690 | [
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Cyclic AMP-stimulated protein kinases at brain synaptic junctions. | We have examined endogenous cyclic AMP-stimulated phosphorylation of subcellular fractions of rat brain enriched in synaptic plasma membranes (SPM), purified synaptic junctions (SJ), and postsynaptic densities (PSD). The analyses of these fractions are essential to provide direct evidence for cyclic AMP-dependent endog... | 216,697 | [
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An ascorbate-mediated transmembrane-reducing system of the human erythrocyte. | Actively metabolizing human erythrocytes catalyze the extracellular reduction of ferricyanide to ferrocyanide. Because neither of these anions can enter the cell, reducing equivalents generated in the course of glycolysis must in some manner be transferred across the cell membrane, thereby resulting in ferricyanide red... | 216,708 | [
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Microbiological aspects of polyphosphate injection in the processing and chill storage of poultry. | During commercial processing of broiler chickens, injection of polyphosphate (Puron 604 or 6040) resulted in microorganisms being added to the deep breast muscle. The level of contamination was related to the microbiological condition of the injection solution. Injection of polyphosphate had no effect on the shelf-life... | 216,743 | [
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Immune response to virus-infection-associated (VIA) antigen in cattle repeatedly vaccinated with foot-and-mouth disease virus inactivated by formalin or acetylethyleneimine. | The results of experiments to investigate antibody to 'virus infection associated' (VIA) antigen in cattle repeatedly vaccinated with formalin- or acetylethyleneimine- (AEI) inactivated foot-and-mouth disease (FMD) vaccines under laboratory conditions are reported. Results are also presented from some vaccinated animal... | 216,744 | [
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Role of thymic hormone (THF) and of a thymic plasma recirculating factor (TPRF) in the modulation of human lymphocyte response to PHA and Con A. | The results presented here point to the possibility that calf thymus extracts contain, in addition to the thymic hormone (THF), a second component: thymic plasma recirculating factor (TPRF). THF, which is involved in the process of T cell maturation and has been characterized as a protein of m.w. 3000 eluted in the voi... | 216,747 | [
-0.02010015,
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0.2336733,
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0.273643,
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Activation of latent murine cytomegalovirus infection: cocultivation, cell transfer, and the effect of immunosuppression. | No free virus was detectable in any organ of DBA/2 mice greater than or equal to 16 weeks after infection with murine cytomegalovirus. Spleens were free of free lytic virus six weeks after infection. Spleen cells from such mice were shown to be latently infected by three methods. First, virus was recovered by cocultiva... | 216,752 | [
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0.2199281,
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The natural history of recurrent facial-oral infection with herpes simplex virus. | Fifty-seven episodes of facial-oral infections with herpes simplex virus (HSV) (cold sores) were studied in 41 ambulatory patients. Patients were examined within 24 hr of the onset of symptoms and for five consecutive days. Clinical parameters were assessed, lesion size was measured, and daily cultures for virus were p... | 216,753 | [
-0.07323802,
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0.03315616,
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Primary anti-viral cytotoxic T-cell responses in semiallogeneic chimeras are not absolutely restricted to host H-2 type. | Chimeras produced by reconstitution of 950 rads irradiated type A or type B host mice with (AXB)F1 fetal liver stem cells were examined in primary (in vivo) and secondary (in vitro) Tc-cell responses to ectromelia virus infection. Of 33 individual chimeras which gave primary responses, 26 produced significant specific ... | 216,768 | [
-0.03591448,
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Calcium pyrophosphate dihydrate crystal formation in model hydrogels. | Using powder x-ray diffraction analysis, we studied calcium pyrophosphate crystal formation in silica and gelatin gels was well as in comparable aqueous solutions. We demonstrated that the physiological salts, monoclinic and triclinic calcium pyrophosphate dihydrate can be formed in gels and that gels do affect the typ... | 216,804 | [
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... |
Phenotypically distinct target cells for murine sarcoma virus and murine leukemia virus marrow transformation in vitro. | An in vitro hematopoietic microenvironment was established from explained fragments of bone marrow from adult noninbred NIH Swiss mice with the use of corticosteroid-reconstituted horse serum. Infection with Kirsten murine sarcoma virus (Ki-MuSV) with either a Rauscher murine leukemia virus (R-MuLV) or Balb:virus-1 hel... | 216,835 | [
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0.1642371,
0.2193882,
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... |
Correlation between the effects of salbutamol on contractions and cyclic AMP content of isolated fast-and slow-contracting muscles of the guinea pig. | The effects of isoprenaline and salbutamol on incomplete tetanic contractions of the isolated soleus (slow contracting) and extensor digitorum longus (EDL-fast-contracting) muscles of the guinea pig were studied and an attempt made to correlate these effects on contractility with changes in cyclic AMP concentrations. S... | 216,932 | [
-0.06187845,
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Studies on ATP: thiamine diphosphate phosphotransferase activity in rat brain. | The experiments described in this paper serve as a contribution to the solution of the discrepancies which exist in the assay of ATP:thiamine diphosphate phosphotransferase activity (EC 2.7.4.15), presently in use as a tool for the diagnosis of Leigh's disease (SNE, subacute necrotizing encephalomyelopathy). The result... | 216,945 | [
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0.6597907,
0.4899718,
0.2284295,
-0.139438... |
The transcerebral arteries. A postmortem arteriographic study. | For precise interpretation of CT brain scan and magnification angiography, an in-depth knowledge of the arteries of the white substance is necessary. Postmortem arteriographic studies on a large series of brains provide us with significant information about morphologic as well as pathological changes, of which a few in... | 216,950 | [
-0.2264021,
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0.2418825,
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0.0... |
Corynebacterium parvum as an adjuvant for Trypanosoma cruzi epimastigote vaccines: a comparison with saponin and Bordetella pertussis. | The effect was compared in CBA mice of adding Corynebacterium parvum, saponin, and Bordetella pertussis to living or killed Trypanosoma cruzi (Y strain) epimastigote vaccines on the induction of protective immunity against subcutaneous (s.c.) challenge with blood trypomastigotes. The addition of C. parvum to a low dose... | 216,967 | [
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0.5791675,
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0.3320943,
0.06231439,
... |
DNA supercoiling by Xenopus laevis oocyte extracts: requirement for a nuclear factor. | A purified system is described for the introduction of negative supercoils into simian virus 40 DNA. The system consists of histones H2A, H2B, H3, and H4, DNA-relaxing enzyme, and a purified factor from Xenopus laevis stage 6 oocyte nuclei. The nuclei are prepared en masse by the technique of F. Scalenghe, M. Buscaglia... | 217,004 | [
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... |
Electron spin resonance studies on interaction of complement proteins with erythrocyte membranes. | Sheep erythrocytes have been spin labeled with 5-, 12-, and 16-nitroxystearic acid in order to investigate complement-induced changes in the physical state of the lipid bilayer. Formation of osmotic lesions in the membrane causes an increase in the fluidity of the membrane which overcomes the decrease in membrane fluid... | 217,005 | [
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0.1592145,
0.1127674,
0.4087644,
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... |
Translocation of a hydrocarbon fluorescent probe between Epstein-Barr virus and lymphoid cells: an assay for early events in viral infection. | Translocation of the hydrocarbon fluorescent probe diphenylhexatriene (DPH) between membranes was studied by fluorescence polarization (P) analysis. First, using a model system, the high P value (0.324) of DPH-labeled cholesterol/phosphatidylcholine liposomes and the low P value (0.157) of DPH-labeled phosphatidylcholi... | 217,012 | [
-0.2714452,
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0.4296342,
0.1430454,
0.4133617,
0.1008056,
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Molecular cloning of polyoma virus DNA in Escherichia coli: plasmid vector system. | A series of recombinant plasmids containing polyoma virus (PY) DNA were constructed, and their biological activity was evaluated in mice and in cultured mouse cells. While all of the recombinants studied contain the complete, potentially infectious viral DNA, in no case was the intact recombinant PY-plasmid DNA, or liv... | 217,087 | [
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0.1375065,
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0.07230253,
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[Aetiological and evolutive Particulars of parinaud's syndrome. Report of 19 cases (author's transl)]. | After a summary of general specifications of Parinaud's syndrome the authors made a critical study according to 19 personal observations. They point to the aetiological interest of evolutive development of this syndrome when undergoing treatment for tumour and during the vascular malformations when fluctuations are an ... | 217,090 | [
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0.5346047,
0.2075427,
0.01391791,
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[Immunologic tests in the prognosis of solid malignant tumors]. | Survival at 6, 12 and 24 months was studied in relation to the immunological findings before treatment and its variations after treatment in 600 patient and its variations after treatment in 600 patients with solid malignant tumours. Any change in any of these tests is a sign of poor prognosis proportional to the degre... | 217,094 | [
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0.... |
[Long term psychiatric treatment and surgical operations]. | Frequently, long term psychiatric treatments are interrupted unfortunately. Although sometimes this interruption is necessary owing to the danger of an anaesthetic, particularly in the case of IMAO, this interruption should be only provisional or else a relapse will occur a few weeks later. It is always advisable to ta... | 217,099 | [
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Epidemiology of breast carcinoma: Age, menstrual status, and exogenous hormone usage in patients with lobular carcinoma in situ. | Lobular carcinoma in situ (LCIS) of the breast is a neoplastic condition associated with premenopausal women and it is largely for this reason that LCIS has been considered to be an estrogen-dependent lesion. In this report we present the results of a study of age at diagnosis, menstrual status, and exogenous hormone u... | 217,115 | [
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0.5437973,
0.3888625,
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[Dacarbacinum (DTIC) and bronchogenic carcinoma (author's transl)]. | A pilot study is reported on the results achieved with the cytostatic agent dacarbacinum (DTIC) on previously untreated, inoperable bronchogenic carcinomas which had been histologically and/or cytologically verified. Altogether there were 16 patients, i.e. 13 males and 3 females. DTIC monotherapy was administered to 14... | 217,183 | [
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0.440899,
0.345486,
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0... |
[Characteristics of the response of mice with temporary immunodepression to the administration of live or inactivated vaccine against tick-borne encephalitis]. | Mice with immunity defects caused by administration of cyclophosphane were inoculated with an inactivated vaccine or Langat virus (TP-21 strain) considered to be an approximate model of the vaccine against tick-borne encephalitis. In mice with depressed immune response, the asymptomatic infection caused by Langat virus... | 217,179 | [
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0.5952424,
0.1064016,
0.3288589,
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0... |
Cytochemical localization of acid phosphatase and adenosine triphosphatase in some avian mechanoreceptors. | Ultrastructural distribution of acid phosphatase and adenosine triphosphatase was studied in the receptor elements of HERBST and GRANDRY sensory corpuscles. Acid phosphatase activity was established in the elements of smooth and rough endoplasmic reticulum of perineural capsule cells, as well as in the secondary lysoso... | 217,219 | [
0.03089097,
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0.4770718,
0.2876631,
0.0994522... |
Oral angiotensin-converting enzyme inhibitor in long-term treatment of hypertensive patients. | The antihypertensive effect of the orally active angiotensin-converting enzyme inhibitor captopril (SQ 14225) was assessed in 22 hypertensive patients of whom 17 were followed for periods ranging from 1 to 7 months. Of these, eight had essential hypertension, eight had renovascular hypertension, and six had hypertensio... | 217,289 | [
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0.4851664,
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0.1591915,
0.05389245,
... |
On betaH-Leu5-endorphin and schizophrenia. | A previously unknown peptide, betaH-Leu5-endorphin, has been reported in the dialysates of schizophrenic patients. Accordingly, hemofiltrates from two schizophrenic and two control patients were examined for the presence of betaH-Leu5-endorphin. The opioid peptides were detected by a radioreceptor assay after separatio... | 217,315 | [
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0.3220575,
0.1433254,
0.... |
Russell bodies in contact-lens-associated giant papillary conjunctivitis. | Biopsy specimens of the upper tarsal conjunctiva in soft contact lens-associated giant papillary conjunctivitis were taken during (1) chronic exacerbation, (2) brief remission, and (3) intentional exacerbation. Inflammatory cells were quantitated and compared with inflammatory cells in normal upper tarsal conjunctivae.... | 217,320 | [
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0.3132351,
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Malate dehydrogenase of the cytosol. A kinetic investigation of the reaction mechanism and a comparison with lactate dehydrogenase. | 1. The mechanisms of the reduction of oxaloacetate and of 3-fluoro-oxaloacetate by NADH catalysed by cytoplasmic pig heart malate dehydrogenase (MDH) were investigated. 2. One mol of dimeric enzyme produces 1.7+/-0.4 mol of enzyme-bound NADH when mixed with saturating NAD+ and L-malate at a rate much higher than the su... | 217,361 | [
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0.2117271,
0.2886778,
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-... |
Lifetimes and NADH quenching of tryptophan fluorescence in pig heart lactate dehydrogenase. | The decay of tryptophan emission from pig heart lactate dehydrogenase following pulsed excitation has been recorded in Tris buffer solution at pH 7.4. All tryptophan residues emit. A good least-squares two-component fit is obtained with I(t)-0.53e-t/1.2 + 0.47e-t/68. A longer lived emitter (r=7.4--8.1 ns) is also obser... | 217,414 | [
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0.2855164,
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0.30... |
H3.H4 tetramer directs DNA and core histone octamer assembly in the nucleosome core particle. | The way in which histones interact with DNA during in vitro assembly of nucleohistone has been examined. Chicken erythrocyte core histones H2A, H2B, H3, and H4 and lambdaDNA in 2 M NaCl were allowed to interact by stepwise decrease in the salt concentration. Binding, although weak, was first observed at 1.4 M NaCl and ... | 217,424 | [
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-0.05774293,
-0.088... |
The purification of Q-containing tRNAs by periodate modification. Purification and nucleoside composition of two related Drosophila tyrosine tRNAs. | A simple procedure for the purification of Drosophila tRNAs which contain the hypermodified nucleoside Q was developed. The cis-diol group of Q renders it susceptible to attack by sodium periodate, with the resultant formation of a hydrophobic pyrrol ring structure. The increase in hydrophobicity after periodate modifi... | 217,435 | [
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... |
Hormonal regulation of three urea cycle enzymes in rat fetal liver. | The purpose of such studies is to identify the hormones that act on the developmental formation of individual urea cycle enzymes, namely argininosuccinate synthetase, argininosuccinate lyase and arginase in the rat fetal liver. The development of argininosuccinate synthetase activity which is completely blocked by the ... | 217,456 | [
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0.0001668292,
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0.0141336,
0.1665205,
0.2400603,
-0.0666023... |
Electrographic analysis of the sleep cycle in young depressed patients. | Electrographic (EEG) patterns of nocturnal sleep were investigated in young psychiatric patients during unipolar depressive episodes. EEG-sleep data was recorded in 20 non-psychotic depressed patients all under 26 years old individually matched with a normal control group. All 20 subjects slept in the laboratory for 1-... | 217,458 | [
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0.1228924,
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[State of vascular tone and several blood biochemical indices in experimental atherosclerosis and sensitization]. | A study of the vascular tone of the posterior extremities in rabbits, of some blood lipid metabolism indices under conditions of experimental atherosclerosis and sensitization showed an increase in the vascular resistance in the areas investigated, and disturbance of lipid metabolism in two experimental groups of anima... | 217,466 | [
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[Effect of taurine on cyclic AMP and GMP levels in the hearts of rats exposed to stress]. | Taurine produced no effect on the cyclic nucleotides level in the heart of intact rats but sharply inhibited the cAMP and cGMP level elevation in the rat heart occuring in stress. After atropine pretreatment of the animals no effect of taurine on the heart cGMP level was observed; its effect on the cAMP level was signi... | 217,468 | [
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Effects of age on brain oxidative metabolism in vivo. | Non-invasive optical techniques were used to monitor the effects of increasing cerebral energy demand on metabolic capabilities and vascular reactivity in young and aged brain. Low level of electrical stimulation of the cortex, in both young (4--7 months) and aged (24--28 months) rat brain, were accompanied by transien... | 217,492 | [
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Immunohistochemical mapping of enkephalin containing cell bodies, fibers and nerve terminals in the brain stem of the rat. | Enkephalin immunoreactive perikarya, fibers and nerve terminals, visualized by the indirect immunohistofluorescent method in colchicine-pretreated animals, are localized in many discrete regions of the rat brain stem. These specific immunohistofluorescent patterns are similar after staining with selective primary antis... | 217,503 | [
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... |
Anabolic steroid therapy and intrahepatic cholangiocarcinoma. | A 47-year-old man who had been treated with an anabolic steroid for refractory anemia developed an intrahepatic cholangiocarcinoma with metastases to abdominal lymph nodes and lungs. Microscopically, the tumor showed mucin production and was devoid of hepatocellular elements. Previous reports have suggested a possible ... | 217,519 | [
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Primary oat cell carcinoma of the larynx: a case report and review of the literature. | A case of an extrapulmonary oat cell carcinoma arising in the larynx of a 45-year-old male is described. Ultrastructural study demonstrated numerous neurosecretory granules in the tumor cells identical to those described in oat cell carcinomas of the lung. Primary oat cell carcinomas of the larynx are highly malignant ... | 217,528 | [
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... |
Characterization of cross-reacting antigens on the Epstein-Barr virus envelope and plasma membranes of producer cells. | A rabbit antiserum has been prepared against the B95-8 transforming strain of EBV. The antiserum has a high virus neutralizing titer (approximately 1:1000) against both the marmoset B95-8 EBV and the human P3HR-1 EBV. The neutralizing antibodies may be absorbed completely with EBV producer cell lines, but not with nonp... | 217,544 | [
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DNA of noninfectious and infectious integrated spleen necrosis virus (SNV) is colinear with unintegrated SNV DNA and not grossly abnormal. | The cleavage sites of eight restriction endonucleases in linear spleen necrosis virus (SNV) DNA were mapped, and the map was oriented with respect to viral RNA. With the aid of this map, several structural features of the viral DNA were elucidated: unintegrated linear SNV DNA is terminally redundant; the majority of SN... | 217,546 | [
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0.2178479,
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-... |
[Cyclic AMP and control of ion exchanges in the fish intestine]. | In isolated intestine of the European Flounder, cyclic AMP and theophylline induce a reduction of the negative transmural potential difference and short circuit current, increase severalfold the passive permeability for chloride and abolish the active transport of this ion. These effects are very different from those d... | 217,555 | [
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0.1177245,
0.2569399,
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-0.003741... |
Toluene di-isocyanate-induced asthma. II. Inhalation challenge tests and bronchial reactivity studies. | In sixty-three workers exposed to toluene di-isocyanate (TDI), no overall differences in bronchial reactivity to histamine inhalation and to exercise testing were found between the total groups of positive and negative TDI reactors to provocation tests. A subgroup of TDI highly sensitive subjects reacting to very low c... | 217,557 | [
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0.07001368,
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0.06330773,
0.1249565,... |
Urinary excretion of mecillinam by volunteers receiving film-coated tablets of pivmecillinam hydrochloride. | Mecillinam is a new amidinopenicillin which is taken orally as its ester pivmecillinam. 10 healthy volunteers were each given 200 mg of pivmecillinam hydrochloride four times daily and all urine was collected and cooled to -20 degrees C to minimize antibiotic degradation. 43% of the ingested antibiotic was recovered fr... | 217,572 | [
-0.4401491,
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0.3079982,
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0.12... |
Enriched populations of rat pituitary thyrotrophs in monolayer culture. | Rat anterior pituitary cells were dissociated and subjected to 4 h of unit gravity sedimentation. Eighty-five 8-ml fractions were collected, and nine pooled fractions were placed in monolayer culture for 1 week. The attached cells were immunocytochemically stained for TSH using an antiserum previously shown to be speci... | 217,594 | [
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0.102847,
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Failure of angiotensin II to inhibit corticotropin-stimulated cortisol secretion. | In view of the reported inhibitory effect of angiotensin II on cortisol secretion in human subjects, the effect of local angiotensin infusions on steroid secretion maintained by ACTH was examined by using sheep with cervical autotransplanted adrenal glands. During sustained submaximal stimulation by exogenous ACTH (40-... | 217,621 | [
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0.... |
Immunochemical measurement of the vitamin D-binding protein in rat serum. | The vitamin D-binding protein (DBP) was measured in rat serum using a single radial immunodiffusion technique. Normal serum levels at birth (74 +/- 11 mg/liter, mean +/- SD) were lower than during the last day of fetal life (130 +/- 14 mg/liter) and much lower than in adult rats. A marked sex difference in DBP occurred... | 217,634 | [
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0.1... |
Developmental changes in testicular gonadotropin receptors: plasma gonadotropins and plasma testosterone in the rat. | The relationships between plasma gonadotropins, testicular gonadotropin receptors, and plasma testosterone were examined during neonatal life and throughout sexual maturation in the rat. The binding affinity of testicular LH receptors (2.4 X 10(10) M-1) was significantly higher than that of FSH receptors (2.1 X 10(9) M... | 217,637 | [
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0.4095401,
0.3059389,
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-... |
Rat adrenal androgen receptor: a possible mediator of androgen-induced decreased in rat adrenal weight. | Many previous studies have demonstrated effects of gonadal steroids on adrenal weight in the rat. Most of these effects are indirect, depending upon alterations in the pituitary-adrenal axis for their expression. In this study we have attempted to examine the direct effects of gonadal steroids on adrenal weight in the ... | 217,667 | [
0.1209958,
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Evidence for activation by beta2-adrenergic receptors of adenosine 3',5'-monophosphate formation in Ehrlich ascites tumor cells. | The existence of aminergic receptors in mouse Ehrlich ascites tumor cells was studied. L-Isoproterenol in vitro stimulated the formation of cAMP in isolated Ehrlich ascites tumor cells. Stimulation by isoproterenol of cAMP formation was not significantly inhibited by practolol, a beta1-adrenoceptor antagonist-Salbutamo... | 217,668 | [
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... |
Specific binding of iodinated growth hormone to rat liver in vivo. | The specific uptake by rat liver of human (hGH) and bovine (bGH) GHs labeled with 125I was studied by an in vivo procedure. A significant reduction of the uptake was observed when labeled hormones were injected together with different amounts of the corresponding native GH. This reduction was dose dependent, and the co... | 217,670 | [
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0.423616,
0.0005820461... |
The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3'-triiodothyronine in pituitary, liver, and kidney of euthyroid rats. | The contributions of local T4 monodeiodination and plasma T3 to the nuclear T3 of anterior pituitary, liver, and kidney were measured in euthyroid rats. After injection of [125I]T4, there was a gradual increase in the quantity of plasma [125I]T3 in excess of injected contaminant, which peaked at approximately 12 h afte... | 217,671 | [
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0.1511834,
0.06601493,
0.5072951,
0.02957087,
-0.07... |
Effect of L-glutamate and kainate on rat cerebellar cGMP levels in vivo. | L-glutamate and kainate administered intracerebroventricularly (i.c.v.) both produced dose-dependent increases in rat cerebellar cGMP. The increased cGMP produced by L-glutamate, but not that produced by kainate, could be completely abolished by the glutamate antagonist glutamate diethylester which had no effect alone.... | 217,702 | [
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0.03444606,
0.03880486,
0.1299663,
0.2427821,
0.... |
Locally evoked potentials in slices of rat neostriatum: a tool for the investigation of intrinsic excitatory processes. | Field potentials, extracellular unitary discharges and intracellular potentials evoked by intrastriatal stimulation were recorded from slices (thickness 200-400 micron) of rat neostriatum maintained in an artificial medium. The field potentials consisted of two negative waves appearing at latencies of 0.5-1.5 ms (N-1) ... | 217,708 | [
-0.245836,
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0.1548968,
... |
Effects of [N-(2-oxo-3,5,7-cycloheptatrien-1-yl)] aminooxoacetic acid ethyl ester (AY-25,674) on cyclic 3',5'-nucleotide formation and phosphodiesterase activity. | The orally-effective antiallergic compound [N-(2-oxo-3,5,7-cycloheptatrien-1-yl)] aminooxoacetic acid ethyl ester (AY-25,674) exhibited a potency equivalent to or 3 times less than theophylline in inhibiting guinea-pig lung and beef heart PDE, respectively, AY-25,674 did not affect the basal activity of guinea-pig lung... | 217,716 | [
-0.143961,
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0.1985119,
0.2919262,
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0... |
[Report on the clinical findings, the treatment, and the course of a case of hemangiofibroma of the adnexa (author's transl)]. | The case of a hemangiofibroma of the right adnexa with locally infiltrative growth is described. The complete operative removal was not possible. A local recurrence was stopped from progressing by ligation of the most important arteries feeding the tumor. Progressive growth was stopped for two years and the patient wih... | 217,798 | [
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0.3393508,
0.143078,
-0.2606308... |
[Anti-D prophylaxis after abortions and interruptions]. | In almost every pregnancy feto-maternal transfusions occur. From the 6th week of pregnancy, blood containing Rhesus antigens may be infused into the maternal circulation and cause sensitization. In case of miscarriage, abortion, ectopic pregnancy and cystic mole the chance of fetomaternal transfusion followed by sensit... | 217,809 | [
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0.1197195,
0.1015942,
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0.15... |
Isolation of the globular region of the subcomponent q of the C1 component of complement. | Digestion after heat treatment of the subcomponent q of the C1 component of complement by collagenase leads to the isolation of the globular region of the protein. This product ('heads') is composed of three chains giving an overall molecular weight of about 57000. About half of the collagen-like region present in C1 q... | 217,814 | [
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0.276398,
-0.217195,
0.03679371,
-0.3107721,
-0.1605919,
-0.101426,
0.1462104,
0.2895236,
0.3267154,
0.02233097,
-0.06376673,
0.1035766,
-0.2338292,
-0.3306397,
0.04722272,
-0.1957149,
-0.1864649,
0.08626116,
0.1395775,
0.3670065,
0.2297909,
-0.1700883,
0.04... |
In vivo suppression of allograft rejection by cyclic AMP increasing agents. | This study was undertaken to elucidate the possibilities of modulating the survival of allogeneic tissue grafts by administration of cyclic AMP-increasing agents to the graft recipients. Heterotopic grafting of split mouse hearts across a strong H-2 barrier was used. It was found that Vibrio cholerae enterotoxin, which... | 217,841 | [
-0.1217444,
-0.3260019,
-0.4820215,
-0.4353753,
-0.02249612,
-0.03092584,
0.1514224,
0.3092049,
0.2350871,
0.05330488,
0.04815654,
0.05708478,
0.08043984,
0.1354981,
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-0.2382749,
-0.1698617,
-0.4785589,
0.1294839,
0.4160798,
0.05819708,
-0.1972672,
... |
Association of osteopetrosis and vitamin D-resistant rickets. | The following report concerns a case of malignant osteopetrosis associated with hypocalcemic rickets unresponsive to vitamin D. Parathyroid hormone (PTH) and Calcitonin (CT) secretions were studied in basal conditions and under calcium gluconate infusion, before and after high doses of vitamin D. Basal values (PTH: 690... | 217,852 | [
-0.2688538,
-0.3670907,
-0.09660493,
-0.2802839,
-0.003364321,
-0.2920146,
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0.180602,
0.2753984,
0.4687234,
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0.3433108,
0.2563508,
0.002001385,
0.5262562,
0.2106531,
-0.1061344,
... |
Rotaviral diarrhea in pigs: brief review. | Rotavirus is a name given to a group of viruses that have similar characteristics and are generally capable of causing diarrhea in the young. Infection of pigs with porcine rotavirus is common and widespread and can result in diarrhea, especially in 1- to 4-week-old pigs. This virus is frequently associated with a diar... | 217,858 | [
-0.1292306,
-0.1933926,
0.1052047,
-0.2969278,
0.02061343,
-0.2397459,
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-0.04650779,
0.3286425,
0.1027045,
0.1063964,
0.3327813,
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0.236952,
0.2234495,
-0.06228839,
-0.06147465,
0.1077056,
-0.3496333,... |
Effect of ammonium salts on the interferon-induced antiviral state in mouse L cells. | The addition of ammonium salts to cells treated with interferon prevents the development of the antiviral state and destroys it when already established. This treatment does not seem to act on the binding of interferon to the cells but blocks a further step of activation on the cell membrane. The anti-interferon effect... | 217,950 | [
-0.08044635,
0.1202794,
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0.2072982,
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0.2020639,
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0.003611096,
0.3167962,
0.09862425,
-0.1315893,
-0.157752... |
The neutralization of transmissible gastroenteritis virus by normal heterotypic serum. | Exposure of transmissible gastroenteritis virus of pigs to unheated normal heterotypic serum resulted in a drop in infectivity, an effect which was lost after heating the serum to 56 degrees C for 30 min or by treatments inactivating complement. Analysis of virus proteins, RNA and lipids, and centrifugation studies sho... | 217,957 | [
-0.1325912,
0.1885558,
0.02108287,
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0.1742154,
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0.2674206,
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0.3242293,
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0.07368905,
0.1527129,
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0.2260693,
0.07991084,
0.1533232,
-0.1481711,
... |
Transformation of rat cells by the hybrid virus Ad2(2+) HEY. | A set of four isogenic rat cell lines transformed by Ad22+ HEY have been studied. While all of the cell lines synthesize SV40 T antigen, only one expresses adenovirus 2 T antigen: none expresses SV40 V antigen or adenovirus 2 fibre antigen. Three cell lines contain 1 to 2 virus equivalents of SV40 and adenoviral sequen... | 217,960 | [
-0.1537844,
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-0.3371635,
-0.2077385,
0.2618481,
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0.2493037,
0.1183777,
0.3548574,
0.07143162,
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0.02484191,
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0.03036615,
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-0.209027,
-0.002689763,
0.2692045,
0.09566333,
-0.1053153,... |
Mechanisms of interferon induced transfer of viral resistance between animal cells. | The sequence of events initiated by interferon and leading to the antiviral state were studied as possible sites for the cell-to-cell transfer of interferon induced viral resistance. The possible role of interferon produced by recipient cells was negated by the demonstration of transfer of resistance in the presence of... | 217,961 | [
-0.1410975,
-0.3148604,
-0.08942515,
-0.01039357,
0.481144,
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0.1188389,
0.3154849,
0.1641906,
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0.07264885,
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0.1335657,
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0.04939415,
-0.2084778,
-0.2137288,
0.4477774,
0.316025,
-0.1672979,
-0.2944464,
... |
Studies on polyoma virus DNA replication in synchronized C3H2K cells. | In G1-arrested cells infected between 1 and 12 h after having been stimulated by fresh serum to progress to S phase, polyoma virus DNA synthesis proceeded in the first half of S phase, and virus and whole cellular DNA accumulated at about the same time. However, in cells infected later than 14 h after serum stimulation... | 217,967 | [
-0.3812923,
-0.313339,
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0.3525891,
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0.1485786,
0.2700855,
0.3259053,
0.2084491,
0.03013016,
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0.2409687,
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-0.1467753,
-0.3461894,
0.3173632,
0.5230169,
-0.04980651,
-0.2065255,
... |
The release of ATP triggered by transmitter action and its possible physiological significance: retrograde transmission. | 1. When a slice of electric organ of Torpedo is stimulated and superfused with a solution containing a firefly lantern extract, it is possible to measure the release of ATP after each nerve impulse as a light emission. 2. The postsynaptic action of released ACh induces the release of ATP by the postsynaptic cell. Most ... | 217,996 | [
-0.06077036,
-0.2692205,
-0.2382209,
-0.09866259,
-0.05516391,
-0.510065,
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0.08978721,
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0.004521963,
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-0.7652807,
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-0.07400633,
0.07697696,
0.5030854,
0.145901,
-0.04... |
[The role of beta and alpha adrenergic receptors in the lipolytic effect of catecholamines on dog adipocytes (author's transl)]. | Pharmacological properties of adrenergic receptors have been investigated in fat cells isolated from omental adipose tissue of the Dog. From the results, the following points can be stated. 1. Lipolysis is markedly enhanced by isoproterenol. This effect is competitively inhibited by propranolol (a beta-adrenoceptor bl... | 218,001 | [
-0.02403174,
-0.1101854,
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-0.3109103,
0.3075354,
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0.005460101,
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0.0005738916,
0.270006,
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0.2570258,
0.2095582,
0.319916,
0.2859732,
0.1042418,
-0.2055151... |
Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties. | Chlornaltrexamine (CNA) produces ultralong-lasting (3--6 days) narcotic antagonism in mice and persistent stereospecific binding to rat-brain homogenate. Protection studies in mice suggest that CNA mediates its narcotic antagonist effects by interacting with the same receptors that are occupied by naloxone. A single ic... | 218,009 | [
0.01364932,
0.06586163,
-0.116875,
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0.2406664,
-0.06837811,
-0.3443529,
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0.1433235,
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0.1989829,
0.2470442,
0.1922462,
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0.09777907,
0.1836978,
0.09880183,
-0.2813689,
0.09860162,
-0.1475204,... |
A model for thyroid hormone--receptor interactions. | Theoretical electronic structure calculations on the thyroid hormones and analogues, as well as model hormone--receptor interactions, have been carried out. These studies (a) support the concept that the 4'-OH group is a H-bond donor to the in vivo nuclear receptor and suggest that at the receptor this OH group is tran... | 218,011 | [
-0.1455437,
0.07932096,
-0.07851535,
0.1405142,
-0.08744217,
-0.119105,
-0.06419059,
0.1526105,
0.04425616,
0.190292,
0.1401349,
0.05474752,
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-0.1798618,
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-0.4229971,
0.2346212,
0.09617176,
0.1437078,
0.1922514,
0.07394435,
-0.2060561,
... |
Membrane-bound phospholipid desaturases. | This review covers studies on membrane-bound phospholipid desaturases in yeast and rat liver carried out in this laboratory. In yeast the desaturase system was shown to effect the direct desaturation of dioleoyl-lecithin to dilinoleoyl-lecithin. In rat liver the desaturase was capable of converting 2-eicosatrienoyl-lec... | 218,072 | [
-0.2180673,
-0.1292837,
-0.1701012,
0.223961,
0.03626371,
-0.162743,
-0.001227664,
0.04389271,
0.05355531,
-0.07331402,
0.096083,
-0.1206791,
0.187031,
0.1539864,
-0.6317132,
-0.03205648,
-0.6229519,
-0.09146595,
-0.1101972,
0.01193381,
-0.03490181,
0.2828156,
-0.1111111,... |
Post-obstructive nephropathy in the rat: relationship between NA-K-ATPase activity and renal function. | Na-K-ATPase activity and renal function were compared in rats studied after relief of 24 h of unilateral or bilateral ureteral ligation (UUL or BUL), that is, in the absence or presence of post-obstructive diuresis. Na-K-ATPase activity in the outer medulla of the rat kidney after relief of UUL was not significantly al... | 218,125 | [
0.07370643,
-0.03437641,
-0.1635018,
-0.04047211,
0.2347329,
-0.4831126,
0.3399515,
-0.1837292,
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0.3508576,
0.07601523,
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0.1350713,
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0.08451673,
0.001527423,
0.2810432,
-0.01904478,
-0.2803254,
0.3399801,
0.09256154,
-0.0558... |
Single-fiber electromyography in myasthenia gravis. | One-hundred-sixty single-fiber EMG studies of the extensor digitorum communis muscle were performed on 127 patients with myasthenia gravis; 131 demonstrated defective neuromuscular transmission. Jitter determinations in the biceps, deltoid or frontalis muscles increased the diagnostic yield significantly. Evoked-potent... | 218,146 | [
-0.1069098,
-0.115509,
0.06839199,
-0.4274739,
-0.01855268,
-0.3780416,
-0.07779893,
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0.2513317,
0.2395746,
0.06754313,
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0.3373424,
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-0.05230088,
0.4537173,
0.06091777,
0.2579798... |
In vitro cultivation of human tumor tissues. II. Morphological and virological characterization of three cell lines. | Nineteen human tumors, mostly of sarcomatous nature, were cultured in vitro. Three cell lines were isolated and further characterized: MG-57 derived from a giant cell tumor, MG-63 derived from an osteosarcoma and MG-72 derived from a xanthohistiocytoma. The cell lines varied in morphology and growth pattern. An abnorma... | 218,153 | [
-0.3578483,
-0.02927428,
-0.1320444,
-0.1888203,
0.1349536,
0.05488827,
-0.4379109,
0.1992161,
0.1787767,
0.2779546,
0.114883,
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0.114694,
0.04260816,
-0.7221692,
0.1592937,
0.05047923,
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-0.1280656,
0.363944,
0.6649088,
-0.06471396,
-0.02679335,
0.... |
An oligosaccharide-containing factor that induces cell differentiation in Dictyostelium discoideum. | When Dictyostelium discoideum amoebae (strain V12 M2) are spread at high density on agar containing 1 mM cyclic AMP, essentially all the cells differentiate into stalk cells after 2-3 days. We showed previously that isolated amoebae plated at low density on agar containing cyclic AMP do not differentiate, but can be in... | 218,195 | [
-0.1213121,
-0.3379921,
-0.1456166,
-0.1029548,
0.173833,
-0.2154473,
-0.1924381,
0.2398404,
0.2358969,
0.1200323,
-0.1717855,
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0.02144193,
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-0.1669939,
-0.1426115,
0.259062,
0.4429782,
0.190897,
-0.3779339,
0.1421... |
Rapid turnover of acetyl groups in the four core histones of simian virus 40 minichromosomes. | The four core histones (H2a, H2b, H3, and H4) bound to simian virus 40 minichromosomes isolated from infected cells contain rapidly labeled acetyl groups in internal positions of the histone polypeptide chain. Upon chase, these acetyl residues decay with a half-life of less than 15 min. The acetyl groups are incorporat... | 218,203 | [
0.006548435,
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0.05159871,
0.2187831,
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0.2347843,
0.1008351,
0.2210143,
0.0859671,
-0.2009335,
0.1755188,
0.08493861,
-0.4040304,
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-0.1184896,
0.1899412,
0.0968605,
-0.05188398,
0.3706394,
0.2019401,
-0.1383347,
-... |
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