title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[NADPH-dependent oxidation in endoplasmic reticulum of rat liver after valexon administration]. | Changes of different type are detected in components of NADPH-dependent oxidation. The changes begin in different periods (1, 5, 15 days) after administration of valexon to the animals. In the first day the hydroxylase activity is inhibited against a background of the uridine diphosphate glucuronyl transferase activity... | 34,910 | [
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Chronic graft versus host disease: a syndrome of disordered immunity. | A chronic, debilitating syndrome related to graft-versus-host disease (GVHD) has been recognized in long-term survivors following allogeneic bone marrow transplantation. In six of 20 marrow graft recipients who survived for more than one year after receiving a transplant, this complication developed; they were studied ... | 35,001 | [
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Acid-base equilibrium during acute long-lasting experiments in artificially ventilated cats. | Experiments were carried out to study blood acid-base equilibrium in the cat during experiments with artificial ventilation. Blood acid-base equilibrium was examined in the arterial and venous blood by analyzing pH, carbon dioxide and oxygen partial pressure, and plasma bicarbonates. Artificial ventilation was regulate... | 35,011 | [
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Comparison of the effects of nine beta-adrenergic blocking agents on intraocular pressure in rabbits. | The intraocular pressure lowering effects of nine beta-adrenergic receptor blocking agents were compared using two different models of experimental ocular hypertension in rabbits. All the nine drugs possess, to different extents, a clear pressure-lowering action after topical administration into the conjunctival sac. F... | 35,031 | [
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Effects of volatile anesthetics on directly and indirectly stimulated skeletal muscle. | Isolated guinea pig nerve-lumbrical muscle preparations were exposed to halothane, methoxyflurane, isoflurane, enflurane, fluroxene, and diethyl ether. The temporal courses of the effects on indirectly and directly elicited twitch responses were determined over a range of concentrations for each agent. When the anesthe... | 35,042 | [
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[Metabolic effects of barbiturates on the anoxic brain:free radical trapping]. | Different mechanisms have been proposed to explain the protector effect of barbiturates in cerebral ischemia. Among these is the particularly attractive hypothesis that the protection is obtained by an inhibition of the oxydo-reduction process in the respiratory chain in the mitochondria upstream of the Q coenzyme. Kee... | 35,052 | [
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[Comparative study of the effects of dobutamine and dopamine in septic shock]. | This work aims at the evaluation of the effects of dobutamine in the effects of dobutamine in the treatment of septic shock and to compare them to the effects of dopamine used in the same conditions. Eleven patients presenting with both a state of septic shock and confirmed cardiac insufficiency were submitted to the p... | 35,059 | [
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[The effects of dobutamine in postoperative disorders of left ventricular function in coronary patients undergoing abdominal surgery. Apropos of 18 cases]. | Increasing doses of dobutamine were administered to the first group of 10 coronarians having undergone and abdominal surgical procedure, and presenting, one hour after awakening from the anesthesia, hemodynamic modifications with a diminution of cardiac index (CI), systolic index (SI), systolic work index of the left v... | 35,061 | [
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[Hemodynamic effects of dopamine, dobutamine and isoproterenol in chronic respiratory insufficiency]. | A study of the effects of dopamine, dobutamine and of isoprenaline was carried out in 20 patients with chronic respiratory insufficiency, 16 of whom had pulmonary arterial hypertension (PAP: 22 mmHg). The following findings emerged: --absence of any significant effect of dobutamine on heart rate,--increase in systolic ... | 35,062 | [
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[Value of and indications for noxythiolin in generalized peritonitis]. | The favourable experience of M. BROWN with noxythiolin in fecal peritonitis has prompted us, over the last seven years, to use this product in all forms of generalized peritonitis. This study involved 187 cases of generalized peritonitis : 102 males and 85 females, whose mean age was 53 years. Noxythiolin was reserved ... | 35,068 | [
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[Acute renal insufficiency caused by phenyl-indane-dione. Apropos of 1 case]. | One case of Phenindione (PID) adverse reaction is reported. The patient showed a typical picture of immunological reaction to the drug. In spite of severe bacteremia, she recovered. Only 33 cases of PID intolerance are reported in the literature. In all these patients, renal failure occurred. Superinfection is the most... | 35,076 | [
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Formation of N-nitrosamines from seconday animes and nitrite by resting cells of Escherichia coli B. | In the presence of resting cells of Escherichia coli B, the formation of N-nitrosamines from nitrite and secondary amines, such as dimethylamine and piperidine, was proportional to the incubation time and to the cell concentration. Optimum pH was 8.0. Boiled cells were incapable of nitrosating secondary amines. Althoug... | 35,098 | [
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Subendocardial protection during cardiopulmonary bypass. Its use with methylprednisolone and glucose-insulin-potassium. | Fifteen adult dogs were equally divided into three groups: group 1 (control) received no medication before or after cardiopulmonary bypass (CPB), group 2 was administered glucose-insulin-potassium (GIK) according to Maroko's protocol before, during, and after CPB, whereas group 3 was treated with methylprednisolone (30... | 35,133 | [
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Zinc(II) binding to apo-(bovine erythrocyte superoxide dismutase). | The binding of zinc(II) ions to apo-(bovine erythrocytes superoxide dismutase) was studied by 1H n.m.r. spectroscopy. Two zinc(II) ions bind to each subunit of the apoenzyme, and the first has a binding constant at least an order of magnitude larger than the second. The nature of the spectral changes that occur on bind... | 35,154 | [
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Artificially induced active transport of amino acid driven by the efflux of a sugar via a heterologous transport system in de-energized Escherichia coli. | Consistent with the model of an H+ cotransport, amino acid uptake can be driven by a proton gradient generated by an efflux of sugar when the normal energy sources are suppressed. Heterologous countertransport is completely inhibited by uncouplers unlike homologous countertransport. Positive coupling was obtained with ... | 35,159 | [
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[The influence of 2-ethyl-3-(4-hydroxy-benzoyl)- benzofuran on the contraction of pial arterial muscles (author's transl)]. | By means of perivascular perfusion of thin sections of pial arteries with differently composed cerebrospinal fluid (CSF) the vessel diameters can be influenced. In cats, anesthetized with pentobarbital, addition of serotonin, norepinephrine or calcium to an artificial CSF which was infused through micropipettes into th... | 35,167 | [
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Kinetics of degradation of cefazolin and cephalexin in aqueous solution. | The kinetics of degradation of cefazolin and cephalexin in aqueous solution were investigated at 60 degrees C and constant ionic strength over the entire pH range. The observed degradation rates were obtained by measuring the residual cephalosporin and were shown to follow pseudo-first-order-kinetics. They were influen... | 35,181 | [
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Single daily dose treatment of anxiety with clobazam or dipotassium clorazepate. | 1 Forty-four clinically anxious patients entered a comparative double-blind trial of clobazam 20 mg, clobazam 30 mg and dipotassium clorazepate 15 mg, all drugs given as a single dose at night. 2 Assessment by the Hamilton Anxiety Scale, Morbid Anxiety Inventory (Salkind) and a Visual Analogue Scale showed a statistica... | 35,192 | [
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Pharmacokinetics of single and multiple doses of clobazam in humans. | 1. The pharmacokinetics of clobazam and its biotransformation product N-desmethylclobazam were investigated after single and multiple doses in normal subjects. 2. The relevant physicochemical properties of clobazam were measured and are presented. Different assay methods (radiochemical, fluorimetric and gas chromatogra... | 35,205 | [
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Pharmacology of anti-anxiety drugs with special reference to clobazam. | 1 In several studies clobazam exhibited a potency which ranges between that of chlordiazepoxide and diazepam. Its anxiolytic and anti-aggression effects are produced by doses usually ranging below those that cause disorders in motor activity. 2 This separation was demonstrable to an even greater degree with the desmeth... | 35,209 | [
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Studies of clobazam and car-driving. | 1 The methodology used in studies to assess the effects of drugs on car-driving performance is reviewed. 2 Clobazam 20 mg, diazepam 10 mg or placebo were administered daily for 3 d to 24-male students with a high neuroticism score (on the Cattell Personality Factors Questionnaire). 3 Car driving performance was assesse... | 35,213 | [
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Conformational transitions and vibronic couplings in acid ferricytochrome c: a resonance Raman study. | Resonance Raman spectral changes in ferricytochrome c as a function of pH between 6.7 and 1.0 are reported and the structural implication is discussed in terms of the "core-expansion" model advanced by L. D. Spaulding et al. [(1975) J. Am. Chem. Soc. 97, 2517]. The data are interpreted as indicating the iron in high-sp... | 35,223 | [
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The enzymatic preparation of [alpha-(32)P]nucleoside triphosphates, cyclic [32P] AMP, and cyclic [32P] GMP. | A method has been developed for the enzymatic preparation of alpha-(32)P-labeled ribo- and deoxyribonucleoside triphosphates, cyclic [(32)P]AMP, and cyclic [(32)P]GMP of high specific radioactivity and in high yield from (32)Pi. The method also enables the preparation of [gamma-(32)P]ATP, [gamma-(32)P]GTP, [gamma-(32)P... | 35,231 | [
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Inactive 3-hydroxy-3-methylglutaryl-coenzyme A reductase in broken cell preparations of various mammalian tissues and cell cultures. | Preincubation of broken cell preparations from a variety of tissues and cell cultures resulted in an apparent increase in the level of 3-hydroxy-3-methylglutaryl-CoA reductase activity. However, apparent activation of the reductase in mouse liver, hepatomas and primary liver cell cultures was attributed largely to the ... | 35,236 | [
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The interference of plasmic degradation products of human crosslinked fibrin with clot formation. | The role of plasmic degradation products of human crosslinked fibrin on polymerization of fibrin monomer and clot formation was studied. Both reactions were inhibited by Fragment DD, which formed a complex with fibrin monomer in a molar ratio 1 : 1. The rate of polymerization was slightly increased by Fragment E but it... | 35,237 | [
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[Role of proton motive force in the infection of E. coli K-12 cells by bacteriophage T4]. | It was shown that infection of E. coli cells by phage T4 is suppressed, when the cells are treated by oxidative phosphorylation uncouplers. The inhibiting effects of the uncouplers manifest themselves at the stage of phage DNA entry into the cells. Study of the E. coli cells devoid of their H+-ATPase activity due to mu... | 35,241 | [
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[Isolation and properties of N-acetyl-beta-D-hexosaminidase from the fungus Hohenbuechelia serotina]. | N-Acetyl-beta-D-hexosaminidase (EC 3.2.1.52) isolated from the fruit bodies of Hohenbuechelia serotina (Fr.) splits N-acyl-p-nitrophenyl-beta-D-glucosaminides acylated at the amino group of the aminosugar by fatty acids, substituted benzoic acids and some amino acids and peptides. The enzyme was purified about 210-fold... | 35,252 | [
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[Changes in postsynaptic excitation processes in the presence of phenazepam]. | The new psychotropic drug phenazepam inhibits the impulse activity of the neurons which compose visceral ganglia of the garden snail (Helix aspersa) and suppresses stimulating postsynaptic potentials arising in application of acetylcholine to the membrane of isolated neurons. The electrostimulating membrane parameters ... | 35,258 | [
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Characterization of an enzyme from Rhizoctonia praticola which polymerizes phenolic compounds. | An extracellular phenol oxidase from the fungus Rhizoctonia praticola which polymerizes various xenobiotic phenols was isolated and characterized. The enzyme was purified by DEAE-cellulose and Sephadex G-200 chromatography followed by preparative polyacrylamide gel electrophoresis. Atomic absorption and EPR spectroscop... | 35,275 | [
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Agenesis or atrophy of the testis and vas deferens. | In this study the author examines the relationship between agenesis or atrophy of the testis and of the vas deferens. From a prospective study of 237 cases of unilateral and bilateral undescended testis, 12 cases of agenesis of a testis were seen; 9 of the 12 cases were associated with agenesis of the vas deferens and ... | 35,276 | [
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0... |
Evaluation of the cytotoxicity of dihydroxytryptamines and 5-hydroxytryptamine antagonists as cytotoxic agents in dimethylhydrazine-induced adenocarcinomata. | The cytotoxicity of 5,6-dihydroxytryptamine (5,6-DHT), 5,7-dihydroxytryptamine (5,7-DHT), bromolysergic acid diethylamide (BOL), methysergide, and cyproheptadine, and also of 5,6-DHT together with either BOL, methysergide, or cyproheptadine in dimethylhydrazine-induced (DMH) carcinomata of rat colon was evaluated by es... | 35,286 | [
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N-Acetyl-beta-D-glucosaminidase activity in normal and chronic lymphocytic leukaemic lymphocytes. | N-Acetyl-beta-D-glucosaminidase (EC 3.2.1.30) activity was measured fluorimetrically in: (a) lymphocytes from 20 normal donors, (b) enriched B and T lymphocyte populations prepared by E rosette sedimentation from 8 normal subjects, (c) lymphocytes from 15 untreated B cell chronic lymphocytic leukaemic patients. The pH ... | 35,292 | [
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Isolation of kidney brush border gamma-glutamyl transpeptidase from urine by specific antibody gel chromatography. | The IgG fraction of antiserum directed against gamma-glutamyl transpeptidase (gammaGTP, EC 2.3.2.2) isolated from human kidney brush border membranes after limited proteolysis, was covalently bound to cyanogen bromide-activated Sepharose. With this antibody-gel, gammaGTP present in the urine of patients as a result of ... | 35,293 | [
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... |
Evaluation of a community-based poison education program. | This study suggests that: (1) a program directed at a specific town and coordinated by a local community group is more effective in transmitting poison control knowledge than is a statewide poison prevention week effort; (2) that transmission of educational material is optimized through programs directed at a specific ... | 35,303 | [
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0.291465,
0.04659873... |
The metabolic disposition of norgestrel in female rhesus monkeys. | Following single intragastric doses of d- and dl-[24C]norgestrel (Ng), rhesus monkeys excreted 29.5 +/- 2.0 (SE) and 52.6 +/- 5.4% of the administered radioactivity in urine. Fecal excretion accounted for 57.1 +/- 4.0 and 37.2 +/- 4.4%, respectively. Urinary radioactivity was separated into neutral, acidic, and conjuga... | 35,318 | [
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Neuropsychological correlates of anticonvulsants and epileptiform discharges in adult epileptics. | Neuropsychological correlates of anticonvulsants and of EEG epileptiform discharges were examined through the administration of neuropsychological measures to groups of adult epileptics. Among the anticonvulsants, performances with high and low serum phenytoin levels were compared and performances with sulthiame vs. ph... | 35,335 | [
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0.1553677,
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[Effect of tranquilizers on impulse conduction in the afferent pathways of visceral nerves]. | Experiments on pyrolaxon-immobilized cats evidence that diazepam produces depression of evoked potentials in the specific, nonspecific and associative brain structures upon an electric stimulation of the visceral and somatic nerves, and also with accoustic and photostimulation; Meprotan (meprobamate) in doses of 40-100... | 35,365 | [
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0.07086512,... |
Assessment of uteroplacental hemodynamics in complicated pregnancy. | Examination of the uteroplacental hemodynamics was performed on 109 occasions in women admitted to the hospital in the third trimester because of various complications of pregnancy. The radioactive tracer 113m In was injected intravenously and the build-up and equilibrium times were measured over the placenta, myometri... | 35,387 | [
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An antacid comparison trial. | A trial is described in which patients going into labour were randomly allocated to treatment with either Andursil or Magnesium Trisilicate Co. Following delivery of the baby the stomach is emptied and the volume and pH are measured. Table 5 summarizes the results of 1106 patients. Andursil was found to be more palatab... | 35,428 | [
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0.031980... |
Some observations on human semen analysis. | Semen analysis of 66 unmarried medical students in the age group of 17-21 years was carried out. A higher liquefaction time pH, motility, lower sperm count and abnormal forms were observed compared to reported values. Liquefaction time, pH and sperm count was found significantly different in non-vegetarians and vegetar... | 35,465 | [
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0.3151058,
0.09975792... |
Mammalian and microbial cell-free conversion of anthracycline antibiotics and analogs. | Cell-free preparations of Streptomyces nogalater and rat liver catalyze reduced pyridine nucleotide dependent conversion of nogalamycin to 7-deoxynogalarol and nogalose (Scheme 1). The mammalian process requires TPNH and has a specific activity of 85 nmoles of 7-deoxynogalarol formed per hour per mg of protein while th... | 35,508 | [
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... |
Identification and partial purification of an ATP-stimulated alkaline protease in rat liver. | Extracts from rat liver contain a sulfhydryl-dependent endoprotease which degrades [methyl-14C]globin or 125I-hemoglobin to acid-soluble peptides. This enzyme was isolated from the 100,000 x g supernatant of the homogenate. It showed a pH optimum between 7.5 and 9.5 and very little activity below pH 7.0. The enzyme has... | 35,530 | [
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Rapid diagnosis of meningitis with use of selected clinical data and gas-liquid chromatographic determination of lactate concentration in cerebrospinal fluid. | The usefulness of determination of lactate concentration in cerebrospinal fluid (CSF) for differentiation between various types of meningitis was evaluated. Lactate concentration in the CSF was assayed by gas-liquid chromatography for 115 patients, 17 of whom had serous meningitis and 38 had bacterial meningitis. The m... | 35,573 | [
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Interaction of amiloride and lithium on distal urinary acidification. | The interaction of amiloride and LiCl administration on renal HCO3 handling was studied in hydropenic rats. Amiloride administration resulted in a significant increase in Na, Cl, and HCO3 excretion, whereas K excretion decreased significantly. LiCl administration resulted in a significant increase in Na, Cl, K, and HCO... | 35,580 | [
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0.01206782... |
GLC analysis of theophylline, hydroxyethyltheophylline, and diphenylpyraline hydrochloride syrup. | A GLC method for determining theophylline, hydroxyethyltheophylline, and diphenylpyraline hydrochloride is presented. The method permits the separation and quantitative determination of the therapeutically active ingredients with a single injection in an overall time of approximately 2.5 hr. | 35,600 | [
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Renal handling of zomepirac sodium (McN-2783-21-98) in the rat. | The plasma and renal clearance of zomepirac, a weak organic acid, was investigated in anesthetized CR Wistar rats after administration of single bolus i.v. injections or continuous i.v. infusions of the 14C-labeled compound. Adjustment of urine pH to the alkaline range caused more than an 8-fold lowering of the plasma ... | 35,605 | [
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Pathophysiologic effects distal to a tourniquet in the dog. | Intramuscular tissue pO2, pCO2, and pH were monitored distal to a pneumatic tourniquet in a dog hindleg preparation. A severe state of tissue hypoxia, hypercarbia, and acidosis was quantitated. The recovery time for tissue gases following release increased with increasing tourniquet time. Elevated c.p.k. and lactic aci... | 35,619 | [
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[Surgical and radiological anatomy of the mandibula (author's transl)]. | One of the risks in dysgnathia-operations performed on the mandibula is the injury to the anatomic formations inside the mandibular channel. The paper deal with anatomic sites recommended in the literature for measurements. The occurrence of a sulcus colli mandibulae and the depth of the bone groove is investigated, an... | 35,699 | [
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... |
[Ganglion in the ulnar nerve groove (author's transl)]. | Two cases of a rare localisation of ganglion is reported in this paper. A ganglion in the ulnar nerve presented by complete loss in ulnar nerve function. Attention is drawn to the importance of early diagnosis, and to the fact, that in cases of ulnar nerve lesions of unknown origin tumors in the ulnar groove must be co... | 35,700 | [
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... |
Myosin polymorphism in human skeletal muscles. | Myosins isolated from individual human muscles (primarily normal muscles) were investigated with respect to their structural and catalytic properties. The results indicate unexpected elements of uniformity shared by the several myosins, such as a three-banded, electrophoretic pattern of light chains in sodium dodecylsu... | 35,746 | [
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Studies on the PR toxin of Penicillium roqueforti. | A mycotoxin, confirmed by chemical, physical and spectroscopic data as the PR toxin described by Ru-Dong Wei and coll. (15) has been isolated from culture filtrates of Penicillium roqueforti Thom. Factors affecting the toxin and mycelium production, acute and chronic toxicity in experimental animals and the frequency o... | 35,751 | [
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... |
[The prehypophyseal-gonadal system in the normal male and in some forms of testicular dyscrinism. Evaluation studies in basic conditions and after stimulation]. | The secretion values of the two seric gonadotropins and of plasmatic testosterone have been estimated in a casuistry of normal males subdivided in groups of 8 to 95 years of age, and of primitive and secondary testicular dyschrinia. In one part of this casuistry, normal and primitive hypogonadics, we have estimated the... | 35,768 | [
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0.4285597,
0.1019175,
... |
Tsetse movement in wind fields: possible epidemiological and entomological implications for trypanosomiasis and its control. | This paper presents evidence that tsetse flies (Glossina) can be dispersed by wind. This dispersal in West Africa is suggested to be along a south-west north-east axis. The implications of wind dispersal of Glossina for chemical and genetic control operations is discussed. Field experiments necessary to test this hypot... | 35,935 | [
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0.583386,
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Influence of the isolation procedure on the structure, neuraminidase and heamagglutinating activities of Sendai virus envelope glycoproteins. | The influence of the isolation procedure of Sendai virus glycoproteins from the virus surface on their neuraminidase and haemagglutinating activities, as well as on some structural properties was studied. These glycoproteins exhibited lower specific neuraminidase and haemagglutinating activities than those of intact vi... | 35,940 | [
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The influence of temperature and pH on the growth of Rickettsia conorii in irradiated mammalian cells. | The temperature range for optimum growth of Rickettsia conorii in suspension culture of gamma-irradiated L cells was 32-38 degrees C, resulting in rickettsial doubling times between 4.1 and 6.0 hr. An asynchronous release of R. conorii from host cells was suggested by the constant increase in percent cells infected ove... | 35,961 | [
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Isolation of Tettnang virus from ticks, mosquitoes and small rodents. | Seven strains of Tettnang virus were isolated in Czechoslovakia: 3 from Ixodes ricinus tick nymphs, males and females, one from Dermacentor reticulatus tick females, one from Aedes cantans mosquitoes and two strains from the brains of Clethrionomys glareolus and Apodemus flavicollis small rodents. | 35,963 | [
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Radiographic manifestations of bone marrow transplantation in children. | Radiographically detectable complications in 35 children after bone marrow transplant are reviewed. These complications are most frequently due to infection, chemoradiotherapeutic toxicity, and graft versus host disease (a transplant rejection phenomenon peculiar to bone marrow transplant patients). The pulmonary compl... | 35,966 | [
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Fiber of the maize tortilla. | Fiber concentrations were measured in maize tortillas and in masa, the lime-treated dough from which they are made, with the aid of Van Soest's methods. Neutral detergent fiber of tortillas was 6.60 +/- 0.98% (mean and SD) and acid detergent fiber 3.75 +/- 0.83% of the dry weight corrected for ash. The hemicellulose fr... | 35,971 | [
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Effect of gastrin I and gastrin II on canine bile flow. | The role of gastrin in the hormonal control of canine hepatic bile flow was evaluated. Because of the importance of the presence of sulfation of the carboxyl terminal peptide in the function of other cholecystokinetic hormones and peptides in the biliary tract, the choleretic properties of sulfated gastrin II were comp... | 35,983 | [
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No barbiturate protection in a dog model of complete cerebral ischemia. | Complete global ischemia was produced in 39 dogs by temporary ligation of the aorta. Prior to the ischemic episode, pentobarbital (30 to 45 mg per kilogram of body weight) was administered to 19 of these dogs. The neurological effects of cerebral ischemia episodes lasting 8, 9, or 10 minutes were compared in dogs treat... | 36,025 | [
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Human tear buffering capacity. | With the use of a closed chamber microelectrode system, we measured the relative buffering capacities of 490 human tear samples from young healthy adults. The buffering capacities of the 457 waking-hour samples did show small but regular oscillations that were similar to those previously reported for blood and tear pH,... | 36,059 | [
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The binding of rat liver cell multiplication-stimulating activity (MSA) to human placenta and serum proteins. | Multiplication-stimulation activity (MSA) from the medium of BRL-3A rat liver cells in culture binds to cell membrane and cytosol receptors from human placenta and to serum proteins. The binding of MSA to placental cell membranes is dependent on time, temperature, pH and divalent ion concentration. MSA bound to placent... | 36,062 | [
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Electron-transport pathway of the NADH-dependent haem oxygenase system of rat liver microsomal fraction induced by cobalt chloride. | The hepatic microsomal haem oxygenase activity of rats treated with CoCl2 was studied kinetically by measuring biliverdin, the immediate product of the reaction. Biliverdin was extracted with diethyl ether/ethanol mixture, and was determined by the difference between A690 and A800. The apparent Km value for NADPH (at 5... | 36,076 | [
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Maprotiline in adult depressed patients. A study of the relation between clinical efficacy and serum concentrations after repeated intravenous and peroral administration. | Maprotiline was administered initially i.v. and then p.o. to 15 adult depressive in-patients daily for three weeks in various dosages. Serum concentrations were monitored in an attempt to find a correlation to clinical response. The steady-state serum concentration attained is independent of the dosage administered. Th... | 36,112 | [
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Comparison of the actions of diazepam and lorazepam. | Diazepam and lorazepam differ in potency and in the time-course of their action. As a sedative, diazepam 10 mg is equivalent to lorazepam 2-2.5 mg. Diazepam is better absorbed after oral than after i.m. administrations but this does not apply to lorazepam. The clinical effect and amnesia begin more rapidly with diazepa... | 36,117 | [
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Kinetics of Mg2+ flux into rat liver mitochondria. | Unidirectional fluxes of Mg2+ across the limiting membranes of rat liver mitochondria have been measured in the presence of the respiratory substrate succinate by means of the radioisotope 28Mg. Rates of both influx and efflux of Mg2+ are decreased when respiration is inhibited. A linear dependence of the reciprocal of... | 36,136 | [
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Urate transport in human red blood cells. Activation by ATP. | Urate transport in human erythrocytes were measured and compared to previous observations by other authors regarding inorganic anions, especially chloride. Conclusions wwere as follows: 1. Urate influx as a function of increasing concentrations showed saturation kinetics. 2. The effects of pH and of several passive ani... | 36,146 | [
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Clustering of fatty acids in phospholipid bilayers. | From electrophoresis experiments it is concluded that acidic phospholipids incorporated in liquid crystalline phosphatidylcholine bilayers at neutral pH are randomly distributed. The same is true for spin-labelled fatty acids. In contrast, long chain fatty acids are not fully ionized at neutral pH and appear to be clus... | 36,148 | [
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Hydrogen cyanide and cyanogen chloride formation by the myeloperoxidase-H2O2-Cl- system. | The chlorination of glycine by the myeloperoxidase-H2O2-Cl- system at acidic pH values yielded N-monochloroglycine and a mixture of HCN and ClCN. HCN was formed as a product of N-dichloroglycine decomposition and cyanogen chloride formation resulted from simultaneous chlorination of HCN by N-chloroglycine or directly b... | 36,154 | [
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Some properties of starch phosphorylase from cotyledons of germinating seeds of Voandzeia subterranea. | Two isoenzymes (Forms I and II) of starch phosphorylase (1,4-alpha-D-glucan: orthophosphate alpha-glucosyltransferase, EC 2.4.1.1) were found in cotyledons of germinating seeds of Voandzeia subterranea L. Thouars. Phosphorylase I, which was the major component, had a pH optimum of 5.5--5.6, whereas phosphorylase II had... | 36,156 | [
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The sulphatase of ox liver. XXII. Further observations on the cerebroside sulphatase activity of sulphatase A. | Further studies have been made of the cerebroside sulphatase activity of the sulphatase A (aryl-sulphate sulphohydrolase, EC 3.1.6.1) of ox liver. It is concluded that a cerebroside sulphate-modified form of the enzyme is not produced and that the kinetics of the reaction can be explained by the utilisation of the subs... | 36,164 | [
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Characterization of specific differences in protein phosphorylation of the plasma membrane and the endoplasmic reticulum of mouse fibroblasts. | Endogenous phosphorylation was studied with highly purified fractions of the plasma membrane and the endoplasmic reticulum of SV40-transformed mouse fibroblasts using [gamma-32P]ATP and [gamma-32P]GTP as precursors. With ATP maximum overall incorporation of 32P into both membrane fractions occurred at pH 7.8 in the pre... | 36,172 | [
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Effects of cholesterol, hydroxycholesterols and calcium on pregnenolone production rates in mitochondrial fractions from rat testes. | The in vitro regulation of the mitochondrial conversion of cholesterol to pregnenolone in rat testis tissue has been further investigated. Pregnenolone production rates by isolated mitochondrial fractions could be stimulated by the addition of cholesterol. The stimulation was always highest in mitochondria isolated fro... | 36,174 | [
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Nonfatal graft-versus-host disease occurring after transfusion with leukocytes and platelets obtained from normal donors. | There have been two previous reports of fatal graft-versus-host (GVH) disease following transfusion of leukocytes from normal donors for the supportive care of leukemic patients. We have reported a nonfatal case of GVH disease in a child with acute monoblastic leukemia who received leukocyte and platelet transfusions f... | 36,181 | [
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The effect of temperature and wavelength on the measurement of creatinine with the Jaffe procedure. | Studies were conducted to determine the effect of temperature and wavelength on the absorbance of alkaline solutions of picric acid in the presence and absence of creatinine. Absorbance values of an alkaline solution of picric acid were found to be influenced by temperature. At wavelength settings between 475 and 520 n... | 36,238 | [
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Tyrosine hydroxylase and the conversion of L-thyroxine into 3',3,5-triiodo-L-thyronone in the rat. | We have studied the effects of alpha-methyl-p-tyrosine (alpha-MPT), an inhibitor of tyrosine hydroxylase, on the in vivo conversion of L-T4 (T4) to 3',3,5-triiodo-L-thyronine (T3), and on the biological effectiveness of T4. Thyroidectomized rats were used and were injected daily with T4 maintenance doses. Three differe... | 36,273 | [
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Beta-adrenoceptor blocking drugs, heart rate and genetic hypertension development in rats. | In spontaneously hypertensive rats (SHRs) chronically treated during their growth with beta-adrenoceptor blocking drugs, no correlation was found between the reduction in heart rate and the prevention of genetic hypertension development. | 36,293 | [
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Effects of drugs on brain neurotransmitter and pituitary-testicular function in male rats. | The effects of different drugs influencing brain neurotransmitter contents have been tested on the pituitary-testicular function in male rats. L-dopa (200 mg/kg body weight, i.p.) increased the dopamine and noradrenaline contents of the hypothalamus, amygdala, striatum and mesencephalon, but it was ineffective as regar... | 36,334 | [
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Innovators gather at conference. | The AHA's Center for Health Promotion invited innovators in the field of community health education programming to exchange ideas and learn from expert consultants. | 36,341 | [
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Clinical studies of thyrotropin-releasing hormone tartrate (TRH-T) as a direct stimulant to the central nervous system. | Thyrotropin-releasing hormone tartrate (TRH-T) was administered in 17 cases of organic brain lesions and 2 cases of disturbed mental activity (psychical depression), and its effect, mainly on the level of consciousness and electroencephalogram, was examined. Ten consecutive administrations of 0.5--1.0 mg/day TRH-T, as ... | 36,357 | [
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... |
Dibenzepin as an antifibrillatory agent for spontaneously terminating electrically induced ventricular fibrillation. | The effect of dibenzepin, a tricyclic antidepressant drug, on electrically induced ventricular fibrillation was studied in 20 cats and nine dogs. The ventricular fibrillation threshold and the ability of the ventricle to defibrillate spontaneously were determined before and after the administration of dibenzepin, with ... | 36,362 | [
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-0... |
Influence of hydrogen and chloride ions on the interaction between sulfaethidole and bovine serum albumin studied by microcalorimetric and acid-base titrimetric methods. | From earlier studies it is known that bovine serum albumin has one high affinity binding site and several lower affinity sites for the sulfa drug N1-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfanilamide (sulfaethidole) (Kostenbauder, H.B., Jawad, M.J., Perrin, J.H., and Averhart, V. (1971) J. Pharm. Sci. 60, 1658-1660). This bi... | 36,383 | [
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0.08568063,
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Acid ribonuclease from HeLa cell lysosomes. | An acid ribonuclease has been purified from HeLa cell lysosomes. The specific activity of the RNase in lysosomes is 8-fold higher than that in nuclei and 15-fold higher than that in the postlysosomal fraction. The purified enzyme showed no detectable DNase, phosphodiesterase, phosphatase, or alkaline RNase activity. Th... | 36,388 | [
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0.1392545,
0.4526653,
0.0231826,
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0.199... |
Regulation of the interaction of purified human erythrocyte AMP deaminase and the human erythrocyte membrane. | The binding of purified human erythrocyte AMP deaminase to human erythrocyte membranes and the effect of binding on enzyme catalytic activity was investigated. AMP deaminase binds preferentially and specifically to the cytoplasmic surface of the erythrocyte membrane. The binding is saturable, reversible, and responsive... | 36,405 | [
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... |
Synthesis of hemoglobin Aic and related minor hemoglobin by erythrocytes. In vitro study of regulation. | Factors that influence hemoglobin (Hb)A(Ic) synthesis by intact erythrocytes were studied in vitro. After incubation cells were lysed, and hemoglobins were separated by isoelectric focusing on polyacrylamide slab gels and quantitated by microdensitometry. HbA(Ic) increased with time, glucose concentrations (5-500 mM), ... | 36,412 | [
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... |
Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. Effects of somatostatin and combined alpha- and beta-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia. | To further characterize mechanisms of glucose counterregulation in man, the effects of pharmacologically inducd deficiencies of glucagon, growth hormone, and catecholamines (alone and in combination) on recovery of plasma glucose from insulin-induced hypoglycemia and attendant changes in isotopically ([3-(3)H]glucose) ... | 36,413 | [
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0.05895184,
0.005722477,
0.1083917,
0.1739704,
0.02464473,
0.00814... |
Effect of naloxone on the sensitivity of the vas deferens to various agonists. | The effect of naloxone in vitro, on noradrenaline (NA)-induced responses in guinea-pig isolated vas deferens was studied. The responses of NA were potentiated by naloxone (3 microM). It potentiated the responses to methoxamine which has least affinity for uptake sites. Responses induced by acetylcholine and potassium c... | 36,460 | [
0.1173473,
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0.3377718,
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0.1187033,
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More acidic metabolites of delta1-tetrahydrocannabinol isolated from rabbit urine. | The in vivo metabolism of delta1-tetrahydrocannabinol (delta1-THC) was further investigated in the rabbit after i.v. administration. Nine acidic metabolites were isolated from a previously not investigated fraction of the urine and identified by gas chromatography-mass spectrometry and by proton magnetic resonance spec... | 36,463 | [
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0.1091024,
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... |
Effects of procaine on the ventricular muscle of bullfrog. | The effects of procaine on the contractility of the bullfrog's ventricular muscle were investigated. The addition of 10(-5) g/ml of procaine potentiated the twitch tension which was accompanied by an elevation as well as a prolongation of the action potential plateau. This positive inotropism of procaine was not induce... | 36,489 | [
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0.04022473,
0.1586296,
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0.634258,
0.09156109,
-0.054720... |
[Dislocations of the talus (author's transl)]. | Authors analysing 31 case histories of talus fractures and following the results in 22 cases over a period of 3--12 years support the general view, that the healing of such injuries is satisfactory but partial or even total necrosis may occur. They emphasize the importance of X-ray investigation and occasional phlebogr... | 36,506 | [
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0.3824767,
0.2826987,
0.0524736,
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0.... |
[The part taken by X-ray investigation for closed soft tissue injuries on the extremities (author's transl)]. | Special X-ray pictures taken of soft tissues for the treatment of closed soft tissue injuries on the extremities, give valuable diagnostic advises. Rupture on the surface of muscles, the lesion to the tendon Achilles and the lig. patellae proprium, tumours, muscle waisting following plexus or periferial nerve lesions e... | 36,513 | [
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0.2916968,
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0.2635078,
0.4137212,
-0.02934919,
-0.06871502... |
Juvenile-onset metachromatic leukodystrophy: biochemical and electrophysiologic studies. | A 15-year-old girl with juvenile-onset metachromatic leukodystrophy (MLD) had markedly decreased leukocyte arylsulfatase A activity and low levels of leukocyte beta galactosidase and serum acid phosphatase. There was marked slowing of nerve condition velocity, and metachromasia was seen in biopsied sural nerve. Leukocy... | 36,575 | [
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0.02733705,
0.01650615,
0.3402064,
0.1003108,
0.1514644,... |
From extracellular to intracellular: the establishment of mitochondria and chloroplasts. | Paracoccus and Rhodopseudomonas are unusual among bacteria in having a majority of the biochemical features of mitochondria; blue-green algae have many of the features of chloroplasts. The theory of serial endosymbiosis proposes that a primitive eukaryote successively took up bacteria and blue-green algae to yield mito... | 36,620 | [
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0.043067,
-0.440443,
0.292008,
0.4003544,
0.08116649,
-0.1... |
The Rhizobium--legume symbiosis. | The rhizobia are soil microorganisms that can interact with leguminous plants to form root nodules within which conditions are favourable for bacterial nitrogen fixation. Legumes allow the development of very large rhizobial populations in the vicinity of their roots. Infections and nodule formation require the specifi... | 36,624 | [
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0.003170334,
0.1909347,
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0.4035973,
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0.08421414,
0.5901135,
-0.110340... |
Effect of desglycinamide(9)-lysine(8)-vasopressin and prolyl-leucyl-glycinamide on oral ethanol intake in the rat. | Rats given ethanol in their drinking water at a concentration that permitted adequate fluid intake gradually accepted higher concentrations and consumed larger amounts of ethanol. These increases were augmented when daily subcutaneous injections of 1 microgram of desglycinamide9-lysine8-vasopressin (DGLVP) or 10 microg... | 36,634 | [
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0.03661113,
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0.1931045,
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0.2042871,
0.09994521,
0.4214696,
-0.014... |
[Endoscopic diagnosis and therapy of colorectal tumours (author's transl)]. | 1. If endoscopy leads to the suspicion of an exulcerated and/or polypous carcinoma of the colon, surgical intervention is the primary therapy. Histological classification of the tumour should be effected by means of endoscopic biopsy. 2. (Familial) adenomatosis of the colon requires colectomy. 3. Broad-based polypi res... | 36,656 | [
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0.190457,
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0.1294393,
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0.3440292,
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0.3456374,
0.2072054,
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0.1689... |
Embryonic development of identified neurons: temporal pattern of morphological and biochemical differentiation. | Individually identified neurons can be recognized in grasshopper embryos, and are accessible to examination by morphological, physiological, and biochemical techniques from their birth to their maturation. Only after the axon of an identified neuron reaches its postsynaptic target does the neurotransmitter accumulate, ... | 36,661 | [
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0.356361,
0.2491774,
0.06183575,
0.254952,
0.3740466,
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-0... |
Food deprivation increases oral and intravenous drug intake in rats. | Rats given continuous access to etonitazene hydrochloride in their drinking water (5 micrograms per milliliter) more than doubled their drug intake while deprived of food. Another group of rats with implanted jugular catheters self-administered etonitazene (10 micrograms per kilogram) intravenously on a continuous rein... | 36,665 | [
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0.06114151,
0.06216828,
0.02429579,
0.202... |
Orchidopexy in cryptorchidism assessed by clinical, histologic and sperm examinations. | A study was undertaken of 187 patients with unilateral and 41 patients with bilateral cryptorchidism before and after orchidopexy. The mean tubular diameter and the mean tubular fertility index were used as quantitative criteria for assessment of the development of the testes. Before orchidopexy, no significant differe... | 36,676 | [
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0.2996462,
0.4506938,
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0.1... |
Gastroesophageal reflux and pulmonary aspiration: incidence, functional abnormality, and results of surgical therapy. | The incidence of aspiration, the causative esophageal pathophysiology, and the results of surgical therapy were evaluated in 100 patients with abnormal gastroesophageal reflux documented by 24-hour esophageal pH monitoring. Based on historical evidence, 48 patients were suspected to be aspirators. Eight patients had do... | 36,677 | [
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0.07193816,
0.01074659,
0.4091758,
0.1090141,
0.1164605,
0.07572429,
-0.10038... |
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